Long-Term Care Drug Database System: Drugs by NDC Class Code, Drug Code and Name
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A Study Into the Localized Corrosion of Magnesium Alloy Magnox Al-80
A Study into the Localized Corrosion of Magnesium Alloy Magnox Al-80 Ronald N. Clark‡*, James Humpage**, Robert Burrows*, Hugh Godfrey***, Mustufa Sagir****, Geraint Williams** ‡Corresponding author. E-mail: [email protected]. *National Nuclear Laboratory, Unit 102B, Sperry Way, National Nuclear Laboratory, Stonehouse, GL10 3UT, UK **Swansea University, Materials Research Centre, Bay Campus, Fabian Way, Crymlyn Burrows, Swansea, SA1 8EN, Wales, UK ***National Nuclear Laboratory, Workington Laboratory, Havelock Road, Derwent Howe, Workington, Cumbria, CA14 3YQ, UK ****Sellafield Limited, Hinton House, Birchwood Park Avenue, Risley, Warrington, Cheshire, WA3 6 GR, UK [email protected] [email protected] [email protected] [email protected] [email protected] ABSTRACT Magnesium (Mg) non-oxidizing alloy, known as Magnox, was historically used as a fuel cladding material for the first-generation of carbon dioxide (CO2) gas-cooled nuclear reactors in the UK. Waste Magnox is currently stored in cooling ponds, pending final disposal. The corrosion resistance of Mg and its alloys is relatively poor, compared to modern cladding materials such as zirconium (Zr) alloys, so it is important to have a knowledge of the chloride concentration/pH dependence on breakdown and localized corrosion characteristics prior to waste retrievals taking place. Our results show that Magnox exhibits passivity in high pH solutions, with charge transfer resistance and passive film thicknesses showing an increase with immersion time. When chloride is added to the system the higher pH maintains Magnox passivity, as shown through a combination of potentiodynamic and time-lapse/post corrosion imaging experiments. Potentiodynamic polarization of Magnox reveals a -229 mV-decade linear dependence of breakdown potential with chloride ion concentration. -
In Vivo Evaluation of Ixabepilone (BMS247550), a Novel Epothilone B Derivative, Against Pediatric Cancer Models Jennifer K
Cancer Therapy: Preclinical In vivo Evaluation of Ixabepilone (BMS247550), A Novel Epothilone B Derivative, against Pediatric Cancer Models Jennifer K. Peterson,1Chandra Tucker,1Edward Favours,1PamelaJ. Cheshire,1Jeremy Creech,1 Catherine A. Billups,2 Richard Smykla,3 Francis Y.F. Lee,3 and Peter J. Houghton1 Abstract Purpose:Vinca alkaloids, agents that cause depolymerization of microtubules, are highly active in treatment of many pediatric cancers. In contrast, taxanes, agents that stabilize microtubules, are far less effective against the same cancer types.The purpose of the current study was to evaluate the antitumor activity of ixabepilone, an epothilone B derivative representing a new class of microtubule-stabilizing antimitotic agent in a wide variety of pediatric solid tumor models. Experimental Design: Ixabepilone was administered i.v. every 4 days for three doses to scid mice bearing s.c. human rhabdomyosarcoma (three lines), neuroblastoma (four),Wilms’ tumors (six), osteosarcoma (four), or brain tumors (seven).Tumor diameters were measured weekly, and tumor growth or regressions were determined. Pharmacokinetic studies were done following a single administration of drug at the maximum tolerated dose (MTD) level (10 mg/kg). Results: At the MTD (10 mg/kg), ixabepilone induced objective responses (all tumors in a group achieved z50% volume regression) in three of three rhabdomyosarcoma lines, three of five neuroblastomas, six of seven Wilms’ tumor models, two of six osteosarcoma, and four of eight brain tumor models. However, the dose-response curve was steep with only 2 of 19 tumors models regressing (z50%) at 4.4 mg/kg. In comparison, paclitaxel administered at the MTD on the same schedule failed to induce objective regressions of three tumor lines that were highly sensitive to treatment with ixabepilone. -
2701.Full-Text.Pdf
Cancer Therapy: Clinical The Effect of Ketoconazole on the Pharmacokinetics and Pharmacodynamics of Ixabepilone: A First in Class Epothilone B Analogue in Late-Phase Clinical Development Sanjay Goel,1Marvin Cohen,4 S. Nilgu« n C¸ o« mezoglu,4 Lionel Perrin,5 Franc¸ois Andre¤ ,5 DavidJayabalan, 1Lisa Iacono,4 Adriana Comprelli,4 Van T. Ly,4 Donglu Zhang,4 Carrie Xu,4 W. Griffith Humphreys,4 Hayley McDaid,1, 2 Gary Goldberg,1, 3 Susan B. Horwitz,1, 2 andSridhar Mani 1 Abstract Purpose:To determine if ixabepilone is a substrate for cytochrome P450 3A4 (CYP3A4) and if its metabolism by this cytochrome is clinically important, we did a clinical drug interaction study in humans using ketoconazole as an inhibitor of CYP3A4. Experimental Design: Human microsomes were usedto determine the cytochrome P450 enzyme(s) involvedin the metabolism of ixabepilone. Computational docking (CYP3A4) studies were done for epothilone B and ixabepilone. A follow-up clinical study was done in patients with cancer to determine if 400 mg/d ketoconazole (inhibitor of CYP3A4) altered the pharmacokinet- ics, drug-target interactions, and pharmacodynamics of ixabepilone. Results: Molecular modeling and human microsomal studies predicted ixabepilone to be a good substrate for CYP3A4. In patients, ketoconazole coadministration resulted in a maximum ixabepi- lone dose administration to 25 mg/m2 when comparedwith single-agent therapy of 40 mg/m 2. Coadministration of ketoconazole with ixabepilone resulted in a 79% increase in AUC0-1.The relationship of microtubule bundle formation in peripheral blood mononuclear cells to plasma ixabepilone concentration was well described by the Hill equation. Microtubule bundle formation in peripheral bloodmononuclear cells correlatedwith neutropenia. -
Anthem Blue Cross Drug Formulary
Erythromycin/Sulfisoxazole (generic) INTRODUCTION Penicillins ...................................................................... Anthem Blue Cross uses a formulary Amoxicillin (generic) (preferred list of drugs) to help your doctor Amoxicillin/Clavulanate (generic/Augmentin make prescribing decisions. This list of drugs chew/XR) is updated quarterly, by a committee Ampicillin (generic) consisting of doctors and pharmacists, so that Dicloxacillin (generic) the list includes drugs that are safe and Penicillin (generic) effective in the treatment of diseases. If you Quinolones ..................................................................... have any questions about the accessibility of Ciprofloxacin/XR (generic) your medication, please call the phone number Levofloxacin (Levaquin) listed on the back of your Anthem Blue Cross Sulfonamides ................................................................ member identification card. Erythromycin/Sulfisoxazole (generic) In most cases, if your physician has Sulfamethoxazole/Trimethoprim (generic) determined that it is medically necessary for Sulfisoxazole (generic) you to receive a brand name drug or a drug Tetracyclines .................................................................. that is not on our list, your physician may Doxycycline hyclate (generic) indicate “Dispense as Written” or “Do Not Minocycline (generic) Substitute” on your prescription to ensure Tetracycline (generic) access to the medication through our network ANTIFUNGAL AGENTS (ORAL) _________________ of community -
Dilantin (Phenytoin Sodium) Extended Oral Capsule Three Times Daily and the Dosage Then Adjusted to Suit Individual Requirements
Dilantin® (Phenytoin Sodium) 100 mg Extended Oral Capsule DESCRIPTION Phenytoin sodium is an antiepileptic drug. Phenytoin sodium is related to the barbiturates in chemical structure, but has a five-membered ring. The chemical name is sodium 5,5-diphenyl-2, 4-imidazolidinedione, having the following structural formula: Each Dilantin— 100 mg Extended Oral Capsule—contains 100 mg phenytoin sodium. Also contains lactose monohydrate, NF; confectioner’s sugar, NF; talc, USP; and magnesium stearate, NF. The capsule body contains titanium dioxide, USP and gelatin, NF. The capsule cap contains FD&C red No. 28; FD&C yellow No. 6; and gelatin NF. Product in vivo performance is characterized by a slow and extended rate of absorption with peak blood concentrations expected in 4 to 12 hours as contrasted to Prompt Phenytoin Sodium Capsules, USP with a rapid rate of absorption with peak blood concentration expected in 1½ to 3 hours. CLINICAL PHARMACOLOGY Phenytoin is an antiepileptic drug which can be used in the treatment of epilepsy. The primary site of action appears to be the motor cortex where spread of seizure activity is inhibited. Possibly by promoting sodium efflux from neurons, phenytoin tends to stabilize the threshold against hyperexcitability caused by excessive stimulation or environmental changes capable of reducing membrane sodium gradient. This includes the reduction of posttetanic potentiation at synapses. Loss of posttetanic potentiation prevents cortical seizure foci from detonating adjacent cortical areas. Phenytoin reduces the maximal activity of brain stem centers responsible for the tonic phase of tonic-clonic (grand mal) seizures. The plasma half-life in man after oral administration of phenytoin averages 22 hours, with a range of 7 to 42 hours. -
(12) Patent Application Publication (10) Pub. No.: US 2010/0221245 A1 Kunin (43) Pub
US 2010O221245A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2010/0221245 A1 Kunin (43) Pub. Date: Sep. 2, 2010 (54) TOPICAL SKIN CARE COMPOSITION Publication Classification (51) Int. Cl. (76) Inventor: Audrey Kunin, Mission Hills, KS A 6LX 39/395 (2006.01) (US) A6II 3L/235 (2006.01) A638/16 (2006.01) Correspondence Address: (52) U.S. Cl. ......................... 424/133.1: 514/533: 514/12 HUSCH BLACKWELL SANDERS LLP (57) ABSTRACT 4801 Main Street, Suite 1000 - KANSAS CITY, MO 64112 (US) The present invention is directed to a topical skin care com position. The composition has the unique ability to treat acne without drying out the user's skin. In particular, the compo (21) Appl. No.: 12/395,251 sition includes a base, an antibacterial agent, at least one anti-inflammatory agent, and at least one antioxidant. The (22) Filed: Feb. 27, 2009 antibacterial agent may be benzoyl peroxide. US 2010/0221 245 A1 Sep. 2, 2010 TOPCAL SKIN CARE COMPOSITION stay of acne treatment since the 1950s. Skin irritation is the most common side effect of benzoyl peroxide and other anti BACKGROUND OF THE INVENTION biotic usage. Some treatments can be severe and can leave the 0001. The present invention generally relates to composi user's skin excessively dry. Excessive use of some acne prod tions and methods for producing topical skin care. Acne Vul ucts may cause redness, dryness of the face, and can actually garis, or acne, is a common skin disease that is prevalent in lead to more acne. Therefore, it would be beneficial to provide teenagers and young adults. -
WATTS 04-2013 P1 PARC Management Team / Bestuurspan Aug
04-2013 WATTS Year 83 + 4m Monthly newsletter of the Pretoria Amateur Radio Club Maandelikse nuusbrief van die Pretoria Amateur Radio Klub. PARC, PO Box 73696, Lynnwood Ridge 0040, RSA web http://www.parc.org.za mail: [email protected] Bulletins: 145,725 MHz 08:45 Sundays/Sondae Relays: 1.840, 3.700, 7.066, 10.135, 14.235, 51.400, 438.825, 1297 MHz ZR6FD logo Activated frequencies are announced prior to bulletins Papier / Paper Drukwerk ZS6RH Swapshop: 2m and 7.066 MHz Live on-air after bulletins ZS6RH Bulletin repeats Mondays | herhalings : Maandae 2m 19:45 Another glimpse of the extensive facility operated by Iain-ZS5IE (more photos on QRZ.com) In this issue In hierdie uitgawe Next club events Fleamarkets at PMC Member news and activities Lede-nuus en Aktiwiteite Wed 1 May (public holiday) Sat 10 Aug Sat 7 Dec Technical Rig reviews Tegnies Club social at U.P. G7FEK limited space antenna Thursday 4 Apr 7pm Aluminium alloys Club committee meeting ● Page eight -- Bladsy agt Thursday 18 Apr 7pm WATTS 04-2013 p1 PARC Management team / Bestuurspan Aug. 2012 – Aug. 2013 Committee members Chairman, Contests Pierre Holtzhausen ZS6PJH [email protected] 012-655-0726 082-575-5799 Vice Chairman, SARL liason Fritz Sutherland ZS6SF [email protected] 012-811-3875 083-304-0028 Secretary, Clubs, Strategy Jean de Villiers ZS6ARA [email protected] 012-663-6554 083-627-2506 Treasurer, SARS Andre van Tonder ZS6BRC [email protected] 361-3292 082-467-0287 Rallies, Social Johan de Bruyn ZS6JHB [email protected] 012-803-7385 079-333-4107 Webmaster Graham Reid ZR6GJR [email protected] 083-701-0511 RAE, Bulletin co-ordinator Vincent Harrison ZS6BTY [email protected] 012-998-8165 083-754-0115 Repeaters, Technical Craig Symington ZS6RH [email protected] 081-334-6817 Technical, Kits. -
Lecture 6 OTC GERD/Heartburn Meghji
Lecture 6 OTC GERD/Heartburn Meghji GASTROESOPHAGEAL REFLUX DISEASE: ALARM SYMPTOMS & WHEN TO REFER: • “A condition that develops when the reflux • Chest pain: radiating pain to shoulders, neck, arm, SOB, sweating of stomach contents causes troublesome • Vomiting: continuous/recurrent symptoms and/or complications” • GI blood loss: hematemesis, melena WHY CHECK FOR ALARM SX? (Montreal Classification) • Dysphagia (difficulty swallowing), especially solids Symptoms could be due or lead to: • Most common symptoms for mild GERD: • Odynophagia (severe pain on swallowing) • Cardiac disease o Heartburn (burning sensation along • Unexplained weight loss > 5% • PUD esophagus) • Unexplained cough, wheezing, choking, hoarseness • Malignancy o Regurgitation (acid/bile that rises to • Age > 50 years old with new symptoms • Functional dyspepsia the back of the throat) • Severe symptoms (frequency, rating) • Biliary disease • Features: • Nocturnal symptoms • Other o May wax and wane • Failure of 2 week H2RA/PPI therapy o Worse when lying down, bending over, or after a meal NON-PHARMACOLOGICAL TX: GOALS OF THERAPY: • Avoid foods/beverages that worsen or trigger symptoms • Treat symptoms CAUSE IS MULTIFACTORIAL: • Eat small meals and chew food well (reduce/eliminate) • Relaxation/decreased integrity of the • Avoid exercise after meals • Reduce or prevent recurrence lower esophageal sphincter • Don’t lie down for 2-3 hours after eating • Prevent structural damage and • Increased lower abdominal pressure • Avoid tight clothing thus complications (e.g. ulcers) -
THE SPECIFICITY of DRUG BINDING SITES on HUMAN SERUM ALBUMIN Ingvar Sjòholm
THE SPECIFICITY OF DRUG BINDING SITES ON HUMAN SERUM ALBUMIN Ingvar Sjòholm Today, it is well established that the binding of drugs in serum will strongly influence the pharmacokinetic parameters of a drug, such as its distribution volume and clearance. It is also evident that the binding of the drug—in serum and elsewhere in the tissues—will have an influence on the duration and intensity of the pharmacological effect. Several excellent papers and reviews have dealt with these issues in recent years.1"** It is obvious that albumin, being the most abundant protein species in the extracellular fluids, is the most im- portant drug-binding protein, although other proteins can play a pharmacokinetic role. Thus, e.g., orosomucoid (aj-acid glyco- protein) can bind some basic and neutral drugs ,9 and lipoproteins some highly hydrophobic drugs.10 The primary structure of human serum albumin (HSA) is now known.1:L'^2 However, all efforts to study the three-dimensional structure by x-ray spectroscopy have hitherto failed, and a detailed knowledge of the mechanisms involved in the binding of drugs or endogenous compounds is still missing. The broad binding specificity of HSA is remarkable. Several compounds of widely different struc- ture can be bound with high affinity—e.g., fatty acids, bilirubin, tryptophan, as well as many drugs. It is also striking that different reports from quantitative studies on the binding of different com- pounds have shown varying results, which cannot be solely explained by technical problems or different experimental conditions. All avail- able information indicates that HSA is a highly "flexible" and "adapt- able" molecule, the structure of which can be strongly influenced by different "modulating" substances. -
Drug Consumption in 2017 - 2020
Page 1 Drug consumption in 2017 - 2020 2020 2019 2018 2017 DDD/ DDD/ DDD/ DDD/ 1000 inhab./ Hospital 1000 inhab./ Hospital 1000 inhab./ Hospital 1000 inhab./ Hospital ATC code Subgroup or chemical substance day % day % day % day % A ALIMENTARY TRACT AND METABOLISM 322,79 3 312,53 4 303,08 4 298,95 4 A01 STOMATOLOGICAL PREPARATIONS 14,28 4 12,82 4 10,77 6 10,46 7 A01A STOMATOLOGICAL PREPARATIONS 14,28 4 12,82 4 10,77 6 10,46 7 A01AA Caries prophylactic agents 11,90 3 10,48 4 8,42 5 8,45 7 A01AA01 sodium fluoride 11,90 3 10,48 4 8,42 5 8,45 7 A01AA03 olaflur 0,00 - 0,00 - 0,00 - 0,00 - A01AB Antiinfectives for local oral treatment 2,36 8 2,31 7 2,31 7 2,02 7 A01AB03 chlorhexidine 2,02 6 2,10 7 2,09 7 1,78 7 A01AB11 various 0,33 21 0,21 0 0,22 0 0,24 0 A01AD Other agents for local oral treatment 0,02 0 0,03 0 0,04 0 - - A01AD02 benzydamine 0,02 0 0,03 0 0,04 0 - - A02 DRUGS FOR ACID RELATED DISORDERS 73,05 3 71,13 3 69,32 3 68,35 3 A02A ANTACIDS 2,23 1 2,22 1 2,20 1 2,30 1 A02AA Magnesium compounds 0,07 22 0,07 22 0,08 22 0,10 19 A02AA04 magnesium hydroxide 0,07 22 0,07 22 0,08 22 0,10 19 A02AD Combinations and complexes of aluminium, 2,17 0 2,15 0 2,12 0 2,20 0 calcium and magnesium compounds A02AD01 ordinary salt combinations 2,17 0 2,15 0 2,12 0 2,20 0 A02B DRUGS FOR PEPTIC ULCER AND 70,82 3 68,91 3 67,12 3 66,05 4 GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD) A02BA H2-receptor antagonists 0,17 7 0,74 4 1,10 4 1,11 5 A02BA02 ranitidine 0,00 1 0,63 3 0,99 3 0,99 4 A02BA03 famotidine 0,16 7 0,11 8 0,11 10 0,12 9 A02BB Prostaglandins 0,04 62 -
Pharmacy and Poisons (Third and Fourth Schedule Amendment) Order 2017
Q UO N T FA R U T A F E BERMUDA PHARMACY AND POISONS (THIRD AND FOURTH SCHEDULE AMENDMENT) ORDER 2017 BR 111 / 2017 The Minister responsible for health, in exercise of the power conferred by section 48A(1) of the Pharmacy and Poisons Act 1979, makes the following Order: Citation 1 This Order may be cited as the Pharmacy and Poisons (Third and Fourth Schedule Amendment) Order 2017. Repeals and replaces the Third and Fourth Schedule of the Pharmacy and Poisons Act 1979 2 The Third and Fourth Schedules to the Pharmacy and Poisons Act 1979 are repealed and replaced with— “THIRD SCHEDULE (Sections 25(6); 27(1))) DRUGS OBTAINABLE ONLY ON PRESCRIPTION EXCEPT WHERE SPECIFIED IN THE FOURTH SCHEDULE (PART I AND PART II) Note: The following annotations used in this Schedule have the following meanings: md (maximum dose) i.e. the maximum quantity of the substance contained in the amount of a medicinal product which is recommended to be taken or administered at any one time. 1 PHARMACY AND POISONS (THIRD AND FOURTH SCHEDULE AMENDMENT) ORDER 2017 mdd (maximum daily dose) i.e. the maximum quantity of the substance that is contained in the amount of a medicinal product which is recommended to be taken or administered in any period of 24 hours. mg milligram ms (maximum strength) i.e. either or, if so specified, both of the following: (a) the maximum quantity of the substance by weight or volume that is contained in the dosage unit of a medicinal product; or (b) the maximum percentage of the substance contained in a medicinal product calculated in terms of w/w, w/v, v/w, or v/v, as appropriate. -
Himalayan Aromatic Medicinal Plants: a Review of Their Ethnopharmacology, Volatile Phytochemistry, and Biological Activities
medicines Review Himalayan Aromatic Medicinal Plants: A Review of their Ethnopharmacology, Volatile Phytochemistry, and Biological Activities Rakesh K. Joshi 1, Prabodh Satyal 2 and Wiliam N. Setzer 2,* 1 Department of Education, Government of Uttrakhand, Nainital 263001, India; [email protected] 2 Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL 35899, USA; [email protected] * Correspondence: [email protected]; Tel.: +1-256-824-6519; Fax: +1-256-824-6349 Academic Editor: Lutfun Nahar Received: 24 December 2015; Accepted: 3 February 2016; Published: 19 February 2016 Abstract: Aromatic plants have played key roles in the lives of tribal peoples living in the Himalaya by providing products for both food and medicine. This review presents a summary of aromatic medicinal plants from the Indian Himalaya, Nepal, and Bhutan, focusing on plant species for which volatile compositions have been described. The review summarizes 116 aromatic plant species distributed over 26 families. Keywords: Jammu and Kashmir; Himachal Pradesh; Uttarakhand; Nepal; Sikkim; Bhutan; essential oils 1. Introduction The Himalya Center of Plant Diversity [1] is a narrow band of biodiversity lying on the southern margin of the Himalayas, the world’s highest mountain range with elevations exceeding 8000 m. The plant diversity of this region is defined by the monsoonal rains, up to 10,000 mm rainfall, concentrated in the summer, altitudinal zonation, consisting of tropical lowland rainforests, 100–1200 m asl, up to alpine meadows, 4800–5500 m asl. Hara and co-workers have estimated there to be around 6000 species of higher plants in Nepal, including 303 species endemic to Nepal and 1957 species restricted to the Himalayan range [2–4].