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Home , Carbenoxolone, Cipralisant, Ciproxifan, Enoxolone, Haloprogin, Isoxicam

US 2010O221245A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2010/0221245 A1 Kunin (43) Pub. Date: Sep. 2, 2010

(54) TOPICAL SKIN CARE COMPOSITION Publication Classification (51) Int. Cl. (76) Inventor: Audrey Kunin, Mission Hills, KS A 6LX 39/395 (2006.01) (US) A6II 3L/235 (2006.01) A638/16 (2006.01) Correspondence Address: (52) U.S. Cl...... 424/133.1: 514/533: 514/12 HUSCH BLACKWELL SANDERS LLP (57) ABSTRACT 4801 Main Street, Suite 1000 - KANSAS CITY, MO 64112 (US) The present invention is directed to a topical skin care com position. The composition has the unique ability to treat acne without drying out the user's skin. In particular, the compo (21) Appl. No.: 12/395,251 sition includes a base, an antibacterial agent, at least one anti-inflammatory agent, and at least one antioxidant. The (22) Filed: Feb. 27, 2009 antibacterial agent may be benzoyl peroxide. US 2010/0221 245 A1 Sep. 2, 2010

TOPCAL SKIN CARE COMPOSITION stay of acne treatment since the 1950s. Skin irritation is the most common side effect of benzoyl peroxide and other anti BACKGROUND OF THE INVENTION biotic usage. Some treatments can be severe and can leave the 0001. The present invention generally relates to composi user's skin excessively dry. Excessive use of some acne prod tions and methods for producing topical skin care. Acne Vul ucts may cause redness, dryness of the face, and can actually garis, or acne, is a common skin disease that is prevalent in lead to more acne. Therefore, it would be beneficial to provide teenagers and young adults. Acne is associated with low an effective acne treatment that also calms the user's skin and self-esteem and social inhibition in those that suffer from does not have a drying effect. acne especially if it is particularly severe. Several factors may 0006 Even good acne treatments may not be able to pre contribute to the development of acne. The primary problem Ventall breakouts of acne. Treatments, such as masks, that are being the abnormal flaking of cells inside the hair follicle that developed specifically to target an acne breakout or appear leads to the formation of a plug. The plug can enlarge and ance of a blemish tend to leave the skin drier and are not even rupture the hair follicle. A ruptured hair follicle spills its always effective. Therefore, it would be beneficial to provide contents of oil and debris into the skin where it leads to an acne treatment that could target a specific breakout or Swelling and causes redness (inflammation). Naturally-oc blemish that does not have a drying effect on the user's skin. curring bacteria known as Propionibacterium acnes may also 0007 Another known treatment of acne and acne break be responsible for causing acne. These bacteria produce Sub outs is injection therapy. Cortisone injection stances that cause redness and irritation (inflammation) and therapy may be very useful as a method of treating acne; also make that dissolve the sebum (oil from oil however these shots can be painful and do not get at the root glands in the skin) and thereby create irritating Substances cause of the acne. Cortisone injection therapy is also not that can make the inflammation worse. Suggested for long-term treatment. Therefore, it would be 0002 Certain hormones called androgens can be an addi beneficial to provide a topical acne treatment that could spe tional factor in causing acne. Androgens are male hormones cifically target a breakout or blemish but could also be used that are present in both men and women and both enlarge the for long-term treatment of acne. sebaceous glands in the skin as well as cause glands to increase sebum production. The increased sebum leads to SUMMARY OF THE INVENTION plug formation and serves as more “food for the bacteria. Androgens Surge at puberty which contributes to the devel 0008. The present invention generally relates to topical opment of acne in teenagers and young adults. skin care compositions and methods for treatment of acne. 0003 Hair follicles exist on virtually all skin except for the The skin care composition hereof has the unique ability to palms of the hands and soles of the feet. Inside the follicle, the treat acne without drying out the user's skin. In particular, a hair extends up from the deep layers of the skin and comes out topical skin care composition is provided that includes a base, of a pore. Near the Surface, the oil gland (sebaceous gland) an antibacterial agent, at least one anti-inflammatory agent enters the hair follicle where it empties sebum at a relatively and at least one antioxidant. In one non-limiting illustration, constant rate. The sebum lubricates the skin and provides a the composition contains benzoyl peroxide, evodia rutae protective barrier to prevent drying. Skin on the face, chest, carpa, boswellia serrata, quercetin, oleanolic acid, and tea and back has an especially large number of sebaceous glands. eXtractS. These are the areas where acne is most likely to occur. 0004. There are two major types of acne lesions: nonin DETAILED DESCRIPTION OF THE INVENTION flammatory and inflammatory. Noninflammatory acne lesions include blackheads (open comedones) and white 0009. There is provided herein a topical skin care compo heads (closed comedones). Open and closed comedones sition that treats acne without drying out the user's skin. The along with papules and pustules are commonly referred to as skin care composition hereof generally includes a base, an papulopustular acne which is a form of inflammatory acne. antibacterial agent, at least one anti-inflammatory agent, and Nodular acne is the most severe form of inflammatory acne. at least one antioxidant. It will be appreciated by those skilled Open comedones result from the enlargement and dilation of in the art that some agents disclosed throughout may have two a plug that forms from oil and flakes of skin inside the hair or more properties; for example, benzoyl peroxide can act as follicle. A closed comedone forms if the hair follicle pore both an antibacterial agent as well as an anti-inflammatory remains closed. Inflammatory acne lesions consist of red agent. blemishes, pimples (papules, pustules), and larger, deeper, 0010. In one embodiment, the skin care composition Swollen, and tender lesions (nodules). Papules are closed includes an effective amount of a base. In certain embodi comedones that have become red, Swollen, and inflamed. ments, the base is present in an amount of from about 1.0 to Pustules are closed comedones that become inflamed and 100.0 w/w % of the composition, more preferably from about begin to rupture into the skin forming pustular heads of vari 10.0 to 95.0 w/w %, and most preferably from about 20 to 95 ous sizes. Nodules represent large, tender, Swollen acne w/w %. Preferred bases include, but are not limited to, soaps, lesions that have become intensely inflamed and rupture washes, lotions, creams, gels, masks, ointments, Solutions, under the skin. If left untreated, these nodules can produce scrubs, microdermabrasion creams, serums, strips, patches, deep Scarring. and combinations thereof. 0005. There are a variety of topical therapies available to 0011. In one embodiment, the skin care composition may treat and prevent acne. Topical Such as tretinoin or also include an effective amount of an antibacterial agent. In adapalene are effective for treating comedonal acne. Inflam certain embodiments, the antibacterial agent is present in an matory lesions benefit from treatment with benzoyl peroxide, amount of from about 0.001 to 20.0 w/w % of the composi aZelaic acid or topical . Benzoyl peroxide, in over tion, more preferably from about 0.15 to 10.0 w/w %, and the-counter and prescription formulations, has been a main most preferably about 5 w/w %. In certain other embodi US 2010/0221 245 A1 Sep. 2, 2010 ments, the antibacterial agent is benzoyl peroxide and is pref reduces glycosaminoglycan degradation and therefore long erably about 5 w/w % of the skin care composition. term use of boswellia does not lead to irritation and has a 0012. In addition to benzoyl peroxide, other antibacterial Soothing effect on human skin. Quercetin is a flavonoid and agents Suitable for use in the present invention include, but are has antioxidant and anti-inflammnatory activities. not limited to, bacitracin, polymyxin B, neomycin, mupiro 0014. Other suitable anti-inflammatory agents for use in cin, hydrastine, aminopropanesulphonic acid, acetohydrox the present invention include, but are not limited to, benzoyl amic acid, actinonin, actinospectacin, aklavin hydrochloride, peroxide, benzoyl peroxide and combinations, alexidine hydrochloride, amikacin Sulfate, amoxicillin, ampi clindamycin, , , alpha hydroxyl cillin , azithromycin, azlocillin Sodium, bacampicillin acid, , filipendula and meadowsweet, curled hydrochloride, bacitracin, becanamycin, butirosin A, cam dock (rumex crispus), licorice extract, acetaminophen, ace phor, , capreomycin Sulfate, carbenicillin diso tylsalicyclic acid, , Zinc oxide, Zinc sulfate, hydro dium, cefadroxil, cefazolin sodium, cefotaxime Sodium, cortisone, , Solumedrol, , white tea cephalosporin Sodium, cephalothin Sodium, cephapirin extract, green tea extract, caffeine, tannis, isatsis indigotica Sodium, cephradine sodium, chloramphenicol hemisucci root extract, , 18alpha-glcyrrhetinic acid, , nate, chloramphenicol, chlorhexidine, chloroxylenol, chlo 3-methyl-1-phenyl-2-pyrazolin-5-one, acacetin, , rtetracycline, , clindamycin hydrochloride, clo aesculin, , amiprilose, amygdalin, , foctol, cloxacillin Sodium, cloxyquin, colistimethate Sodium, , gynnestemma, , esculin, , fen cycloserine, , demeclocycline hydrochloride, bufen, , , flumethasone, flumet dibekacin, dihydrostreptomycin Sulfate, doxycycline hydro haZone pivalate, , acetonide, fluoci chloride, , erythromycinestolate, erythromycin eth nonide, , flurandrenolide, , ylsuccinate, erythromycin propionate lauryl Sulfate, erythro fosfosal, gentisic acid, guaiaZulene, , hecogenin, mycin Stearate, erythromycin, ethambutol dihydrochloride, butyrate, , indomethacin, idnopro ethionamide, , fusidic acid, gambogic acid, gen fen, , , tromethamine, mefe tamicin Sulfate, gentian violet, haloprogin, helenine, hetacil namic acid, n-(9-fluorenylmethoxycarbonyl)-1-leucine, lin potassium, , kanamycin Sulfate, kojic acid, livi , , , , nordihy domycin A, hydrochloride, meclocycline droguaretic acid, DHT inhibitors, nordihydroguaiaretic acid, sulfosalicylate, methacycline hydrochloride, methicillin , drosperinone, propecia, BCPS, parthenolide, Sodium, minocycline hydrochloride, moxalactam disodium, oxypenbutaZone, picrolimus, ramiphenaZone, Sodium sodium, neomycin sulfate, nigericin sodium, nitro dichlofenac, Sodium meclofenamate, Solasodine, , furantoin, , Sodium, oleandomycin , , , , tolfenamic phosphate, oligomycin, oxacillin Sodium, oxytetracycline, acid, citrate, hydrochloride, parachlorophenol, paromomycin Sulfate, patulin, penicillin G sodium, , beclomethasone dipropionate, potassium, penicillin V potassium, phenethicillin potassium, sodium, celastrol, propionate, dex piperacillin Sodium, , polymyxin B Sulfate, amethasone acetate, dexmethasone sodium phosphate, pyrithione Zinc, roXarsone, Sisomicin Sulfate, Streptomycin , pivalate, , fenspiride Sulfate, Sulfabenzamide, , Sulfachlorpy hydrochloride, hydrocortisone acetate, hydrocortisone ridazine, , , Sulfaguanidine, Sul hemisuccinate, , , , fameter, , Sulfamethazine, , Sul acetonide, triamcinolone benetonide, triamci famethoxazole, , nolone diacetate, flutamide, acetate, finasteride, Sulfamonomethoxine, , Sulfanitran, Sul aminolevulinic acid HCL, derivatives thereof, and mixtures faphenazole, Sulfaquinoxaline sodium, , thereof. Sulfisoxazole, thiamphenicol, , Vancomycin 0015. In addition, other suitable anti-inflammatory agents hydrochloride, Vulpinic acid, tyrothricin, derivatives thereof, for use in the present invention include, but are not limited to, or mixtures thereof alix alba bark extract (willow bark), hamamelis Virginiana 0013. In one embodiment of the present invention, the skin distillate (witch hazel), or a mixture thereof. Willow bark is a care composition also includes an effective amount of an natural source of Salicyclic acid thought to clarify blemish anti-inflammatory agent. In certain embodiments, the antiin prone, oily or combination skin. Witch hazel is a natural flammatory agent is present in an amount of from about 1.0 to astringent that gently leaves the complexion radiant. The 20.0 w/w % of the composition, more preferably from about advanced polymer technology soaks up excess oils and mat 5.0 to 15.0 w/w %, and most preferably from about 10.0 to tifies without leaving skin parched that aids in prevention of 15.0 w/w %. Suitable anti-inflammatory agents include, but acne. The botanically derived agents help calm and sooth are not limited to, evodia rutaecarpa extract, boswellia Serrata inflamed and irritated skin. The natural botanicals are an ideal extract, quercetin, derivatives thereof, or mixtures thereof. antidote for hormonally out-of-control skin. Evodia rutaecarpa extract, also known as Wu-Zhu-Yu, has 0016. In certain other embodiments, the anti-inflamma anti-inflammatory properties when applied topically to tory is an . Suitable for use in the human skin. Boswellia serrata is a medium- to large-sized present invention include, but are not limited to, bromphe branching tree found in dry hilly areas of India, North Africa, niramine maleate, diclofenac, carbenoXolone sodium, chlor and the Middle East. The boswellia tree exudates terpenoids, maleate, , diphenhy oils and gum resins that are collectively called baswellic acids dramine hydrochloride, hydrochloride, and have an anti-inflammatory action much like conventional Succinate, HCL, cinnarazine, chlor nonsteroidal agents. Boswellia inhibits pro-inflammatory phenhydramine maleate, naphazoline hydrochloride, phe mediators in the body, specifically leukotrienes via inhibition niramine maleate, , flufenazine hydrochloride, of 5-lipoxygenase. However, in contrast to conventional non , , sodium, , steroidal anti-inflammatorv drugs, boswellia significantly , , , hyydroxy Zine US 2010/0221 245 A1 Sep. 2, 2010

pamoate, doxephin HCL, , naphtha 0.75% caffeine, 0.75 , 0.75% disodium lenesulfonate, hydrochloride, EDTA, 0.75% sorbitol, 0.75% tea carbomer, 0.5% imadazo citrate, pheniramine maleate, pyrilamine maleate, , lidinyl urea and methylparaben and propylparaben and eth , ranitidine, , hydrochlo ylparaben and butylparaben, 0.1% titanium dioxide, 0.015% ride, experimental H-3 and H-4 antagonists, for example, peppermint essential oil, 0.01% menthol, and 0.01% citric ABT-239, , , clobempropit, thioperam acid. ide, phosphate derivatives thereof, and mixtures 0020. In an alternate embodiment, the topical skin care thereof. composition includes deionized water, benzoyl peroxide, 0017. In certain embodiments, the skin care composition dimethicone, glycerine, bentonite, Stearyl , cetyl alco also includes an effective amount of an antioxidant which hol, glyceryl Stearate, PEG-100 stearate, capric caprylic trig Soothes the appearance of redness in skin. In certain embodi lyceride, myristyl alcohol, myristyl glucoside, glycyrrhiza ments, the antioxidant is present in an amount of from about glabra (licorice) root extract, oleanic acid, nordihydroguai 1.0 to 20.0 w/w % of the composition, more preferably from aretic acid, osmotic gel, dipotassium glycyrrhitinate, white about 5.0 to 15.0 w/w '%, and most preferably from about 10.0 tea extract, caffeine, Superoxide dismutase, disodium EDTA, to 15.0 w/w %. An antioxidant suitable for use in the present imidazolidinyl urea, methyl, paraben, probylparaben, ethly application includes, but is not limited, oleanolic acid, tea paraben, and butylparaben. extracts, derivatives thereof, or mixtures thereof. Other suit 0021. In yet another embodiment, a topical skin care com able antioxidants for use in the present invention include, but position includes deionized water, ethoxydiglycol or buty are not limited to, 3-methyl-1-phenyl-2-pyrazolin-5-one, lene glycol, dimethicone, glycerine, bentonite, Stearyl alco ebselen, pomiferin, trisodium tetracetate, hol, cetyl alcohol, glyceryl Stearate, PEG-100 stearate, phytochemicals, nordihydroguaiaretic acid, green tea salicylic acid, capric caprylic triglyceride, myristyl alcohol, extracts, chromolaena odorata extracts, derivatives thereof, myristylglucoside, glycyrrhiza glabra (licorice) root extract, and mixtures thereof. In certain embodiments, the skin care oleanic acid, nordihydroguaiaretic acid, osmotic gel, dipotas composition may also include from about 0.001 to about 5.0 sium glycyrrhitinate, white tea extract, caffeine, Superoxide W/w % of an additive Such as fragrance, pH adjuster, or the dismutase, disodium EDTA, imidazolidinyl urea, methyl, like. paraben, propylparaben, , and butylparaben. 0018. In one embodiment, the topical skin care composi 0022. From the foregoing it will be seen that this invention tion hereof includes about 5.0% benzoyl peroxide, from is one well adapted to attain all ends and objects hereinabove about 55% deionized water, 5.0% denatured alcohol or set forth together with the other advantages which are obvious SD-40B alcohol or grain alcohol. 4.0% glycerine, 3.0% and which are inherent to the composition. It will be under boswellia serrata extract, 3.0% ethoxydiglycol, 3.0% querce stood that certain features and Subcombinations may be tin, 3.0% lecithin, 3.0% C12-C16 alcohols, 3.0% palmitic employed without reference to other features and subcombi acid, 3.0% dimethicone, 3.0% cetyl alcohol. 2.0% stearyl nations. This is contemplated by and is within the scope of the alcohol, 2.0% glyceryl Stearate, 2.0% PEG-100 stearate, claims. Since many possible embodiments may be made of 3.0% bentonite, 2.0% caprylic/capric triglyceride, 2.0% the invention without departing from the scope thereof, it is to myristyl alcohol. 2.0% myristyl glucoside, 1.0% sorbitol, be understood that all matter herein set forth is to be inter 1.0% glycyrrhiza glabra (licorice) root extract, 2.0% butylene preted as illustrative, and not in a limiting sense. glycol, 2.0% PEG-60 almond glycerides, 1.0% caprylyl gly What is claimed is: col, 1.0% carbomer, 3.0% nordihydroguairaretic acid, 3.0% 1. A topical skin care composition comprising: oleanic acid, 1.0% evodia fruit extract, 1.0% a base butylene glycol, 1.0% dipotassium glycyrrhizate, 1.0% an antibacterial agent; camelia oleifera (Japanese green tea) extract, 1.0% camelia at least one anti-inflammatory agent; and sinensis (white tea) leaf extract, 1.0% rosmarinus officinalis at least one antioxidant. (rosemary) leaf extract, 1.0% caffeine, 1.0% superoxide dis 2. The composition of claim 1 wherein said base is selected mutase, 1.0% disodium EDTA, 1.0% imidazolidinyl urea, from the group consisting of Soaps, washes, lotions, creams, 1.0% methylparaben, 1.0% propylparaben, 1.0% ethylpara gels, masks, ointments, solutions, Scrubs, microdermabrasion ben, 1.0% butylparaben, 1.0% titanium dioxide, 1.0% pep creams, serums, strips, and patches. permint oil, 1.0% menthol, 1.0% fragrance, 1.0% citric acid 3. The composition of claim 1 wherein said antibacterial and 1.0% TEA Carbomer. agent is selected from the group consisting of benzoyl peroX 0019. In another embodiment, the topical skin care com ide, bacitracin, polymyxin B, neomycin, mupirocin, hydras position includes about 55.0% deionized water, 5.0% dena tine, aminopropanesulphonic acid, acetohydroxainic acid, tured alcohol SD-40B, 2.25% dimethicone, 3.5% glycerine, actinonin, actinospectacin, aklavin hydrochloride, alexidine 3.0 boswellia serrata extract, 2.5% bentonite, 2.75 ethoxydig hydrochloride, amikacin Sulfate, amoxicillin, amplicillin lycol and quercetin and ecithin and C12-C 16 alcoahols-an Sodium, azithromycin, azlocillin Sodium, bacampicillin palrmitic acid, 2.0% stearyl alcohol. 2.25% cetyl alcohol, hydrochloride, bacitracin, becanamycin, butirosin A, cam 1.75% glyceryl Stearate and PEG-100 stearate, 1.5% capric/ phor, cannabidiol, capreomycin Sulfate, carbenicillin diso caprylic triglyceride, 1.25% myristyl alcohol and myristyl dium, cefadroxil, cefazolin sodium, cefotaxime Sodium, glucoside, 1.0 sorbitol, 1.0% glycyrrhiza glabra (Licorice) cephalosporin Sodium, cephalothin Sodium, cephapirin root extract, 1.0% butylene glycol and PEG-60 almond glyc Sodium, cephradine sodium, chloramphenicol hemisucci erides and caprylylglycol and nordihydroguaiaretic acid and nate, chloramphenicol, chlorhexidine, chloroxylenol, chlo oleanic acid, 0.075% camellia oleifera (Japanese Green Tea) rtetracycline, ciprofloxacin, clindamycin hydrochloride, clo extract, camellia sinensis (White Tea) leaf extract, 1.0% evo foctol, cloxacillin Sodium, cloxyquin, colistimethate Sodium, dia rutaecarpa fruit extract, 0.75% dipotassium glycyrrhiti cycloserine, dapsone, demeclocyline hydrochloride, dibeka nate, 0.75% rosmarinus officinal (Rosemary) leaf extract, cin, dihydrostreptomycin Sulfate, doxycycline hydrochlo US 2010/0221 245 A1 Sep. 2, 2010

ride, enoxacin, erythromycin, erythromycin ethyl Succinate, aminolevulinic acid HCL, alix alba bark extract, hamamelis estolate, erythromycin propionate lauryl Sulfate, erythromy Virginiana distillate, antihistamines, derivatives thereof, and cin Stearate, erythromycin, ethambutol dihydrochloride, mixtures thereof. ethionamide, flumequine, fusidic acid, gambogic acid, gen 6. The composition of claim 5 wherein said DHT inhibitors tamicin Sulfate, gentian violet, haloprogin, helenine, hetacil are selected from the group consisting of Spironolactone, lin potassium, isoniazid, kanamycin Sulfate, kojic acid, livi drosperinone, propecia, BCPS, nordihydroguaiaretic acid domycin A, mafenide hydrochloride, meclocycline and mixtures thereof. sulfosalicylate, methacycline hydrochloride, methicillin 7. The composition of claim 5 wherein said alpha binding Sodium, minocycline hydrochloride, moxalactam disodium, proteins are selected from the group consisting of infliximab, nafeillin sodium, neomycin Sulfate, nigericin Sodium, nitro etanercept, adalimumab, and mixtures thereof. furantoin, norfloxacin, novobiocin Sodium, oleandomycin 8. The composition of claim 5 wherein said antihistamines phosphate, oligomycin, oxacillin Sodium, oxytetracycline, are selected from the group consisting of parachlorophenol, paromomycin Sulfate, patulin, penicillin G maleate, diclofenac, carbenoXolone sodium, chlorphe potassium, penicillin V potassium, phenethicillin potassium, niramine maleate, dexbrompheniramine, piperacillin Sodium, piperine, polymyxin B Sulfate, hydrochloride, diphenylpyraline hydrochloride, doxylamine pyrithione Zinc, roXarsone, Sisomicin Sulfate, Streptomycin Succinate, cetirizine HCL, cinnarazine, chlorphenhydramine Sulfate, Sulfabenzamide, Sulfacetamide, Sulfachlorpy maleate, naphazoline hydrochloride, pheniramine maleate, ridazine, Sulfadiazine, Sulfadimethoxine, Sulfaguanidine, Sul famotidine, flufenazine hydrochloride, ketotifen, omepra famneter, Sulfamerazine, Sulfamethazine, Sulfamethizole, Zole, pantoprazole Sodium, ranitidine, cimetidine, cyprohep , Sulfamethoxypyridazine, sulfa tadine, clemastine, hyydroxy Zine pamoate, doxephin HCL, monomethoxine, Sulfanilamide, Sulfanitran, , loratadine, mebhydrolin naphthalenesulfonate, methapy Sulfaquinoxaline Sodium, Sulfathiazole, Sulfisoxazole, thiam rilene hydrochloride, orphenadrine citrate, pheniramine phenicol, trimethoprim, Vancomycin hydrochloride, Vulpinic maleate, pyrilamine maleate, meclizine, quetiapine, raniti acid, tyrothricin, hydrastine, derivatives thereof, or mixtures dine, terfenadine, thonzylamine hydrochloride, experimental thereof. H-3 and H-4 antagonists, for example, ABT-239, cipralisant, 4. The composition of claim 1 wherein said antibacterial ciproxifan, clobempropit, and , derivatives agent is about 5% benzoyl peroxide. thereof, and mixtures thereof. 9. The composition of claim 1 wherein said antioxidant is 5. The composition of claim 1 wherein said anti-inflam selected from the group consisting of brompheniramine matory agent is selected from the group consisting of benzoyl maleate, diclofenac, carbenoXolone sodium, chlorphe peroxide, benzoyl peroxide and clindamycin combinations, niramine maleate, dexbrompheniramine, diphenhydramine clindamycin, erythromycin, tetracycline, alpha hydroxyl hydrochloride, diphenylpyraline hydrochloride, doxylamine acid, Salicylic acid, filipendula and meadowsweet, curled Succinate, cetirizine HCL, cinnarazine, chlorphenhydramine dock (rumex crispus), licorice extract, acetaminophen, ace maleate, naphazoline hydrochloride, pheniramine maleate, tylsalicyclic acid, acetic acid, Zinc oxide, Zinc sulfate, hydro famotidine, flufenazine hydrochloride, ketotifen, omepra cortisone, prednisone, Solumedrol, prednisolone, white tea Zole, pantoprazole Sodium, ranitidine, cimetidine, cyprohep extract, green tea extract, caffeine, tannis, isatsis indigotica tadine, clemastine, hyydroxy Zine pamoate, doxephin HCL, root extract, menthol, 18alpha-glcyrrhetinic acid, naproxen, loratadine, mebhydrolin naphthalenesulfonate, methapy 3-methyl-1-phenyl-2-pyrazolin-5-one, acacetin, acemetacin, rilene hydrochloride, orphenadrine citrate, pheniramine aesculin, amcinonide, amiprilose, amygdalin, budesonide, maleate, pyrilamine maleate, meclizine, quetiapine, raniti bufexamac, gynnestemma, ebselen, enoXolone, esculin, etod dine, terfenadine, thonzylamine hydrochloride, experimental olac, , fenoprofen, flufenamic acid, flumethasone, H-3 and H-4 antagonists, for example, ABT-239, cipralisant, flumethaZone pivalate, flunisolide, , ciproxifan, clobempropit, and thioperamide, derivatives , fluorometholone, flurandrenolide, flurbiprofen, thereof, and mixtures thereof. fosfosal, gentisic acid, guaiaZulene, halcinonide, hecogenin, 10. The composition of claim 1 comprising at least one , ibuprofen, indomethacin, idnopro additive. fen, isoxicam, ketoprofen, ketorolac tromethamine, mefe 11. The composition of claim 10 wherein said additive is namic acid, n-(9-fluorenylmethoxycarbonyl)-1-leucine, selected from the group consisting of at least one additive, nabumetone, nifenaZone, niflumic acid, nimeSulide, nordihy wherein said additive is selected from a group consisting of droguaretic acid, DHT inhibitors, nordihydroguaiaretic acid, deionized water, C-12-C-16 alcohols, butylene glycol, spironolactone, drosperinone, propecia, BCPS, parthenolide, PESG-60 almond glycerides, denatured alcohol, nordihy oxypenbutaZone, picrolimus, ramiphenaZone, sodium droguaiaretic acid, oleanolic acid, glycerin, ethoxydiglycol, dichlofenac, Sodium meclofenamate, Solasodine, Sulindac, quercetin, lecithin, palmastic acid, bentonite, dimethicone, Suprofen, SuxibuZone, tacrolimus, tenoxicam, tolfenamic cetyl alcohol, stearyl alcohol, glyceryl Stearate, PE6-100 acid, tripelennamine citrate, triprolidine hydrochloride, Stearate, caprylic/capric triglyceride, myristyl alcohol, myri Zomepirac sodium, aspirin, beclomethasone dipropionate, stylglucoside, Sorbitol, caprylyl glycol, glycyrrhiza glabra carbenoXolone sodium, celastrol, , dex root extract, TEA carbomer, disodium EDTA, evodia rutae amethasone acetate, dexmethasone sodium phosphate, carpa extract, dipotassium glycyrrhizate, camellia oleifera diclofenac, diflucortolone pivalate, diflunisal, fenspinrde extract, camellia sinensis extract, rosmarinus officinalis hydrochloride, hydrocortisone acetate, hydrocortisone extract, caffeine, Superoxide dismutase, imidazolidinyl urea, hemisuccinate, phenylbutaZone, piroxicam, pregnenolone, titanium dioxide, peppermint essential oil, methanol, citric , triamcinolone benetonide, triamci acid, methylparaben, propylparaben, ethylparaben, butyl nolone diacetate, flutamide, , finasteride, paraben, derivatives thereof, and mixtures thereof. US 2010/0221 245 A1 Sep. 2, 2010

12. A topical skin care composition comprising: namic acid, flumethasone, flumethaZone pivalate, a base, wherein said base is selected from the group con flunisolide, fluocinolone acetonide, fluocinonide, fluo sisting of soaps, washes, lotions, creams, gels, masks, rometholone, flurandrentolide, flurbiprofen, fosfosal, ointments, Solutions, scrubs, microdermabrasion gentisic acid, guaiaZulene, halcinonide, hecogenin, creams, serums, strips, and patches; hydrocortisone butyrate, ibuprofen, indomethacin, an antibacterial agent, wherein said antibacterial agent is idnoprofen, isoxicam, ketoprofen, ketorolac Selected from the group consisting of benzoyl peroxide, tromethamine, , n-(9-fluorenyl bacitracin, polymyxin B, neomycin, mupirocin, hydras methoxycarbonyl)-1-leucine, nabumetone, nifenaZone, tine, aminopropanesulphonic acid, acetohydroxamic niflumic acid, nimeSulide, nordihydroguaretic acid, acid, actinonin, actinospectacin, aklavin hydrochloride, DHT inhibitors, nordihydroguaiaretic acid, spironolac alexidine hydrochloride, amikacin Sulfate, amoxicillin, tone, drosperinone, propecia, BCPS, parthenolide, ampicillin Sodium, azithromycin, aZlocillin Sodium, OxypenbutaZone, picrolimus, ramiphenaZone, Sodium bacampicillin hydrochloride, bacitracin, becanamycin, dichlofenac, Sodium meclofenamate, Solasodine, Sulin butirosin A, camphor, cannabidiol, capreomycin Sulfate, dac, Suprofen, SuxibuZone, tacrolimus, tenoxicam, tolfe carbenicillin disodium, cefadroxil, cefazolin Sodium, namic acid, tripelennamine citrate, triprolidine hydro cefotaxime Sodium, cephalosporin Sodium, cephalothin chloride, Zomepirac sodium, aspirin, beclomethasone Sodium, cephapirin Sodium, cephradine Sodium, chloramphenicol hemisuccinate, chloramphenicol, dipropionate, carbenoXolone sodium, celastrol, clobeta chlorhexidine, chloroxylenol, chlortetracycline, ciprof Sol propionate, acetate, dexmethasone loxacin, clindamycin hydrochloride, clofoctol, cloxacil Sodium phosphate, diclofenac, diflucortolone pivalate, lin sodium, cloxyquin, colistimethate Sodium, cyclos diflunisal, fenspiride hydrochloride, hydrocortisone erine, dapsone, demeclocyline hydrochloride, acetate, hydrocortisonehemisuccinate, phenylbutaZone, dibekacin, dihydrostreptomycin Sulfate, doxycycline piroXicam, pregnenolone, triamcinolone acetonide, tri hydrochloride, enoxacin, erythromycin, erythromycin amcinolone benetonide, , fluta ethyl Succinate, estolate, erythromycin propionate lau mide, cyproterone acetate, finasteride, aminolevulinic ryl Sulfate, erythromycin Stearate, erythromycin, etham acid HCL, alix alba bark extract, hamamelis Virginiana butol dihydrochloride, ethionamide, flumequine, fusidic distillate, antihistamines, derivatives thereof, and mix acid, gambogic acid, gentamicin Sulfate, gentian violet, tures thereof, and haloprogin, helenine, potassium, isoniazid, at least one antioxidant, wherein said antioxidant is kanamycin Sulfate, kojic acid, lividomycin A, mafenide Selected from the group consisting of brompheniramine hydrochloride, meclocycline Sulfosalicylate, methacy maleate, diclofenac, carbenoXolone sodium, chlorphe cline hydrochloride, methicillin sodium, minocycline niramine maleate, dexbrompheniramine, diphenhy hydrochloride, moxalactam disodium, nafcillin Sodium, dramine hydrochloride, diphenylpyraline hydrochlo neomycin Sulfate, nigericin Sodium, , nor ride, doxylamine Succinate, cetirizine HCL, floxacin, novobiocin Sodium, oleandomycin phosphate, cinnarazine, chlorphenhydramine maleate, naphazoline oligomycin, oxacillin Sodium, oxytetracycline, hydrochloride, pheniramine maleate, famotidine, parachlorophenol, paromomycin Sulfate, patulin, peni flufenazine hydrochloride, ketotifen, omeprazole, pan cillin G potassium, penicillin V potassium, phenethicil toprazole Sodium, ranitidine, cimetidine, cyprohepta lin potassium, piperacillin Sodium, piperine, polymyxin dine, clemastine, hyydroxy Zine pamoate, doxephin B sulfate, pyrithione Zinc, roXarsone, Sisomicin Sulfate, HCL, loratadine, mebhydrolin naphthalenesulfonate, streptomycin Sulfate, Sulfabenzamide, Sulfacetamide, methapyrilene hydrochloride, orphenadrine citrate, phe Sulfachlorpyridazine, Sulfadiazine, Sulfadimethoxine, niramine maleate, pyrilamine maleate, meclizine, que Sulfaguanidine, Sulfameter, Sulfamerazine, SulfamethaZ tiapine, ranitidine, terfenadine, thonzylamine hydro ine, Sulfamethizole, Sulfamethoxazole, Sulfamethoxy chloride, experimental H-3 and H-4 antagonists, for pyridazine, Sulfamonomethoxine, Sulfanilamide, Sul example, ABT-239, cipralisant, ciproxifan, clobenpro fanitran, Sulfaphenazole, Sulfaquinoxaline Sodium, pit, and thioperamide, derivatives thereof, and mixtures Sulfathiazole, Sulfisoxazole, thiamphenicol, trimethop thereof. rim, Vancomycin hydrochloride, Vulpinic acid, tyrothri 13. The composition of claim 12 wherein said antibacterial cin, hydrastine, derivatives thereof, or mixtures thereof; agent is about 5% benzoyl peroxide. at least one anti-inflammatory agent, wherein said anti 14. The composition of claim 12 comprising at least one inflammatory agent is selected from the group consist additive, wherein said additive is selected from the group ing of benzoyl peroxide, benzoyl peroxide and clinda consisting of at least one additive, wherein said additive is mycin combinations, clindamycin, erytliromycin, selected from a group consisting of deionized water, C-12-C- tetracycline, alpha hydroxyl acid, salicylic acid, filipen 16 alcohols, butylene glycol, PESG-60 almond glycerides, dula and meadowsweet, curled dock (rumex crispus), denatured alcohol, nordihydroguaiaretic acid, oleanolic acid, licorice extract, acetaminophen, acetylsalicyclic acid, glycerin, ethoxydiglycol, quercetin, lecithin, palmastic acid, acetic acid, Zinc oxide, Zinc sulfate, hydrocortisone, bentonite, dimethicone, cetyl alcohol, Stearyl alcohol, glyc prednisone, Solumedrol, prednisolone, white tea extract, eryl Stearate, PE6-100 stearate, caprylic/capric triglyceride, green tea extract, caffeine, tannis, isatsis indigotica root myristyl alcohol, myristylglucoside, Sorbitol, caprylyl gly extract, menthol, 18alpha-glcyrrhetinic acid, naproxen, col, glycyrrhiza glabra root extract, TEA carbomer, disodium 3-methyl-1-phenyl-2-pyrazolin-5-one, acacetin, acem EDTA, evodia rutaecarpa extract, dipotassium glycyrrhizate, etacin, aesculin, amcinonide, amiprilose, amygdalin, camelia oleifera extract, camellia sinensis extract, roSmari budesonide, bufexamac, gynnestemma, ebselen, enox nus officinalis extract, caffeine, Superoxide dismutase, imi olone, esculin, etodolac, fenbufen, fenoprofen, flufe dazolidinyl urea, titanium dioxide, peppermint essential oil, US 2010/0221 245 A1 Sep. 2, 2010

methanol, citric acid, methylparaben, propylparaben, eth consisting of at least one additive, wherein said additive is ylparaben, butyl paraben, derivatives thereof, and mixtures selected from a group consisting of deionized water, C-12-C- thereof. 16 alcohols, butylene glycol, PESG-60 almond glycerides, 15. A topical skin care composition comprising: denatured alcohol, nordihydroguaiaretic acid, oleanolic acid, glycerin, ethoxydiglycol, quercetin, lecithin, palmastic acid, a base, wherein said base is selected from the group con bentonite, dimethicone, cetyl alcohol, Stearyl alcohol, glyc sisting of soaps, washes, lotions, creams, gels, masks, eryl Stearate, PE6-100 stearate, caprylic/capric triglyceride, ointments, solutions, scrubs, microdennabrasion myristyl alcohol, myristylglucoside, Sorbitol, caprylylgly creams, serums, strips, and patches; col, glycyrrhiza glabra root extract, TEA carbomer, disodium an antibacterial agent, wherein said antibacterial agent is EDTA, evodia rutaecarpa extract, dipotassium glycyrrhizate, about 5% benzoyl peroxide: camelia oleifera extract, camellia sinensis extract, roSmari at least one anti-inflammatory, wherein said anti-inflam nus officinalis extract, caffeine, Superoxide dismutase, imi matory is evodia rutaecarpa, boswellia serrate, and quer dazolidinyl urea, titanium dioxide, peppermint essential oil, cetin; and methanol, citric acid, methylparaben, propylparaben, eth at least one antioxidant, wherein said antioxidant is olean ylparaben, butyl paraben, derivatives thereof, and mixtures olic acid and tea extract. thereof. 16. The composition of claim 15 comprising at least one additive, wherein said additive is selected from the group