Curriculum vitae Mihály Kovács Mihály Kovács

Date of birth: 23/08/1975 Current position: Associate Research Professor, Principal Investigator (2005-) ELTE-MTA “Momentum” Motor Enzymology Research Group (2011-) Department of Biochemistry, Institute of Biology, Eötvös Loránd University (ELTE) 1117 Budapest, Pázmány Péter sétány 1/C, Hungary Tel.: +36-1-372-2500/8401 Fax: +36-1-381-2172 Email: [email protected] Web: www.mk-lab.org

Education, degrees M.Sc. (Biology, ELTE, 1998) Ph.D. (Structural Biochemistry, summa cum laude, ELTE, 2002) Postdoctoral training (National Institutes of Health (NIH) (USA), 2002-2005) Habilitation (Biology, ELTE, 2008) D.Sc. (Hungarian Academy of Sciences (MTA), 2012)

Languages Hungarian (native) English (fluent) German (intermediate)

Fellowships EMBO Fellowship (Max-Planck-Inst. for Medical Research, Heidelberg, 1998) Hungarian State Eötvös Fellowship (Univ. of Leicester, 2000) EMBO Fellowship (Univ. of Leicester, 2001) NIH Visiting Fellowship (NIH, 2002-2005) Bolyai Fellowship (final evaluation: outstanding) (ELTE-MTA, 2006-2009) Bolyai Fellowship (ELTE-MTA, 2010-2013)

Prizes Student Excellence Award (ELTE, 1998) Lenfant Biomedical Fellowship Award (NIH, 2004-2005) Fellows Award for Outstanding Research (NIH, 2004) Fellows Award for Research Excellence (NIH, 2004) Sigma-Aldrich Award, 1st Prize (Sigma-Aldrich Hungary, 2008) Talentum Prize (MTA, 2009) Ignaz L. Lieben Prize (Austrian Academy of Sciences, 2011) Faculty of 1000 Evaluation (2012) Orloff Science Award (NIH, 2013)

Scientometry International peer-reviewed articles: 41 First authorship: 12 Last authorship: 13 Corresponding authorship: 16 Cumulative impact factor: 260.025

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Curriculum vitae Mihály Kovács

Total citations: 1306/1005/1048 (Google Scholar/Web of Science/mtmt) Independent citations: 1171/902/803 (Google Scholar/Web of Science/mtmt) H-index: 17/16/16 (Google Scholar/Web of Science/mtmt) Book chapters: 3 Articles and interviews in Hungarian: 15 Interviews in English: 1 Conference abstracts: 113

Research grant support (as Principal Investigator) NIH Global Health Research Initiative (ELTE, 2005-2010, 203 kEUR) EMBO-HHMI Startup (ELTE, 2006-2008, 168 kEUR) OTKA Basic Research (ELTE, 2008-2012, 86 kEUR) OTKA-Norway Fund (ELTE, 2009-2011, 89 kEUR) OTKA-Norway Fund (ELTE, 2011-2012, 36 kEUR) HFSP Research Grant (ELTE, 2010-2013, 340 kEUR) MTA “Momentum” Program (ELTE, 2011-2016, 514 kEUR) Total as PI: 1,436 kEUR

Research grant support (as participant) OTKA Basic Research (ELTE, 2005-2009) OTKA Basic Research (ELTE, 2010-2013) EU TÁMOP (ELTE, 2010-2012) EU FP7 Marie Curie IOF (ELTE, coordinator, 2012-2014) OTKA Basic Research (ELTE, 2013-2016)

Invited lectures Functional adaptations of non-muscle myosin II (Eastern Virginia Medical School (EVMS), 2004) Mechanism of inhibition of myosin II by blebbistatin (EVMS, 2004) Action and inhibition of cytoplasmic myosin II (Hannover Medical School, 2006) Deciphering the mechanochemistry of RecQ-family DNA helicases (Masaryk University, 2010) Molecular motors in the cytoplasm and in the nucleus (Vellore Institute of Technology (VIT), 2010) In addition, 32 invited conference lectures (marked * in Conference abstracts)

Research interest Effect of mechanical load on biochemical processes Mechanisms of force production by motor enzymes (myosins, DNA helicases) Biochemical basis of motor function; functional adaptations of motors to cellular roles Effects of disease-causing mutations on the mechanoenzymatic function of myosins and helicases Small-molecule inhibitors of molecular motors Mechanisms of action and genome-maintaining roles of DNA helicases

Technical experience Molecular biology, nucleic acid manipulation, cloning, mutagenesis, cell culture, recombinant protein expression Protein purification, chemical modification of biomolecules, protein chemistry Steady-state and time-resolved fluorescence spectroscopy Steady-state and transient enzyme kinetics: rapid mixing (stopped-flow, quenched-flow) and relaxation methods (temperature-jump, pressure-jump, flash photolysis) Computational kinetic and structural modeling

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Single molecule fluorescence, motility and force spectroscopic assays DNA binding, unwinding and annealing assays

Conference chairmanship Biophysical Society (USA) (BPS) Meeting (Unconventional myosins, 2005) BPS Meeting (Myosin and myosin-family proteins, 2007) BPS Meeting (Myosin and myosin-family proteins, 2008) Hungarian Biochemical Society Meeting (Protein machines, 2009) European Muscle Conference (Contractile actin-myosin interactions, 2011) BPS Meeting (Motility subgroup, 2013)

Teaching B.Sc. level Biochemistry and molecular biology (practicals, ELTE, 1998-2002; 2005-) Biochemistry and molecular biology (lectures, ELTE, 2012-) M.Sc. level PCR techniques (practicals, ELTE, 2000) Recombinant DNA (practicals, ELTE, 2000-2002; 2006-) Motor proteins (lectures, ELTE, 2006-) Biochemistry and molecular biology (lectures, ELTE, 2008-) Biophysics (lectures, MAFIHE International Summer School in Physics, 2009) Protein Science (lectures, ELTE, 2010-) Bioregulation (lectures, BME, 2013-) Ph.D. level Motor proteins (lectures, NIH, 2003-2005) Transient enzyme kinetics (lectures, EVMS, 2004) Fluorescence spectroscopy (practicals, ELTE, 2005-) Transient enzyme kinetics (lectures and practicals, ELTE, 2006-) Transient enzyme kinetics (lectures and practicals, FEBS Practical Course on Structure, Folding and Dynamics of Proteins and Their Complexes, 2009) 21st-century Enzymology (lectures, 4th European Conference on Chemistry for Life Sciences, 2011)

Degree advisorship B.Sc.: 3 completed Judit Szabó (ELTE, 2009) Judit Gervai (ELTE, 2010) Eszter Molnár (ELTE, 2010) M.Sc.: 9 completed, 1 ongoing (*) Judit Tóth (ELTE, 2002) Patrick Rodgers (NIH, 2003) Nikolett Nagy (ELTE, 2008) Kata Sarlós (ELTE, 2008) Hajnalka Sarankó (ELTE, 2009) Gábor Harami (ELTE, 2010) Debasish Roy (ELTE-VIT, 2011) Judit Gervai (ELTE, 2012) Eszter Molnár (ELTE, 2012) Máté Martina (ELTE, 2013*)

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Ph.D.: 4 completed, 4 ongoing (*) Judit Tóth (ELTE-NIH, 2006) Balázs Takács (ELTE, 2011) Kata Sarlós (ELTE, 2012) András Bibó (BME, 2013) Nikolett Nagy (ELTE, 2013*) Zsuzsa Kocsis (ELTE, 2013*) Gábor Harami (ELTE, 2013*) Veronika Ferencziová (ELTE, 2015*) Postdoctoral Máté Gyimesi (ELTE, 2007-2012)

Achievements of mentees Prizes at National Student Conferences Kata Sarlós (3rd Prize, 2007) Máté Martina (1st Prize, 2013) Prizes at ELTE Student Conferences Kata Sarlós (1st Prize, 2006) Nikolett Nagy (2nd Prize, 2007) Gábor Harami (1st Prize, 2010) Máté Martina (3rd Prize, 2012) Participation at ELTE Student Conferences Judit Gervai (2011) Eszter Molnár (2011) ELTE Student Excellence Awards Judit Tóth (2002) Kata Sarlós (2008) Gábor Harami (2010) Other Prizes Kata Sarlós (Poster Prize at Molecular Recognition Conference, 2007) Máté Gyimesi (Prize of the Hungarian Biochemical Society, 2010) Kata Sarlós (Prize of the Hungarian Biochemical Society, 2013) Fellowships Kata Sarlós (EMBO Fellowship, 2011) Máté Gyimesi (EU FP7 Marie Curie International Outgoing Fellowship, 2012) Zsuzsa Kocsis (Jedlik Ányos Predoctoral Fellowship, National Excellence Program, 2013)

Present career of lab alumni Balázs Jelinek (research manager, 2005-2009) Málnási-Csizmadia group, Eötvös University Hajnalka Sarankó (M.Sc., 2009) Hegedűs group, Membrane Biology Research Group, Budapest, Hungary Debasish Roy (M.Sc., 2011) Vellore Institute of Technology, Vellore, Tamil Nadu, India Balázs Takács (Ph.D., 2011) Westermann group, Research Institute of Molecular Pathology, Vienna, Austria Judit Gervai (M.Sc., 2012) Szüts Group, Institute of Enzymology, Hungarian Academy of Sciences Kata Sarlós (Ph.D., 2012) Hickson group, University of Copenhagen, Denmark Máté Gyimesi (postdoc, 2007-2012) Kowalczykowski group, University of California, Davis, USA

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Committee memberships Fellows Advisory Committee (NIH, 2003-2005) Board of Supervisors (Hungarian Biochemical Society, 2011-) Scientific Committee for Biochemistry, Molecular Biology, Genetics and Cell Biology (MTA, 2011-) Vice Chair, Student Scientific Research Council in Biology (ELTE, 2012-)

Society memberships Hungarian Biochemical Society (2000-) European Society for Muscle Research (2001-) American Society for Cell Biology (2003-) BPS (2003-) Public Body of MTA (2006-)

Other community activities Public science writing (see Articles and interviews in Hungarian, 2002-) Organization of departmental research seminars (ELTE, 2006-) Invitation of guest lecturers (ELTE, 2006-): 11 occasions Public and media appearances (National Talent Development Council, Hungarian Innovation Association, Society of Hungarian Young Scientists, OTKA, see also Media appearances, 2009-) Society Research Achievement Awards Poster Judge (BPS, 2011)

Journal article reviews Journal of Biological Chemistry (2003-) Journal of Biochemical and Biophysical Methods (2005-) Medical Science Monitor (2005-) Cell Biology International (2006-) Biophysical Journal (2007-) FEBS Journal (2009-) EMBO Journal (2009-) International Journal of Molecular Sciences (2010-) Cellular and Molecular Life Sciences (2011-) Interface Focus (2011-)

Grant review and board membership OTKA (2009-) MTA (2011-) National Excellence Program (2012-)

Degree review and board membership M.Sc. thesis review (ELTE, 2006-): 6 occasions Ph.D. thesis review (ELTE, BME, PTE, 2006-): 6 occasions Ph.D. final exam board membership (ELTE, SE, 2006-): 9 occasions Ph.D. thesis board membership (ELTE, BME, SE, 2006-): 16 occasions Habilitation review (ELTE, 2012-): 1 occasion D.Sc. pre-review (MTA, 2012-): 1 occasion

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Peer-reviewed international research articles *: equal contributions corresponding author articles

1. Málnási-Csizmadia, A., Kovács, M., Woolley, J. R., Botchway, S. W., Bagshaw, C. R. (2001): The dynamics of the relay loop tryptophan residue in the Dictyostelium myosin motor domain and the origin of spectroscopic signals. J. Biol. Chem. 276: 19483-90. 2. Málnási-Csizmadia, A., Pearson, D. S., Kovács, M., Woolley, R. J., Geeves, M. A., Bagshaw, C. R. (2001): Kinetic resolution of a conformational transition and the ATP hydrolysis step using relaxation methods with a Dictyostelium myosin II mutant containing a single tryptophan residue. Biochemistry 40: 12727-37. 3. Kovács, M., Málnási-Csizmadia, A., Woolley, J. R., Bagshaw, C. R. (2002): Analysis of nucleotide binding to Dictyostelium myosin II motor domains containing a single tryptophan near the active site. J. Biol. Chem. 277: 28459-67. 4. Wakelin, S., Woolley, R. J., Floyd, D. N., Bagshaw, C. R., Kovács, M., Málnási-Csizmadia, A. (2002): Engineering Dictyostelium discoideum myosin II for the introduction of site-specific fluorescence probes. J. Muscle Res. Cell Motil. 23: 673-683. 5. Wang, F.*, Kovács, M.*, Hu, A., Limouze, J., Harvey, E. V., Sellers, J. R. (2003): Kinetic mechanism of non-muscle myosin IIB: functional adaptations for tension generation and maintenance. J. Biol. Chem. 278: 27439-48. 6. Kovács, M.*, Wang, F.*, Hu, A., Zhang, Y., Sellers, J. R. (2003): Functional divergence of human cytoplasmic myosin II: kinetic characterization of the non-muscle IIA isoform. J. Biol. Chem. 278: 38132- 40. 7. Conibear, P. B., Bagshaw, C. R., Fajer, P., Kovács, M., Málnási-Csizmadia, A. (2003): Myosin cleft movement and its coupling to actomyosin dissociation. Nat. Struct. Biol. 10: 831-5. 8. Kovács, M., Tóth, J., Nyitray, L., Sellers, J. R. (2004): Two-headed binding of the unphosphorylated non-muscle heavy meromyosin-ADP complex to actin. Biochemistry 43: 4219-26. 9. Kovács, M., Tóth, J., Málnási-Csizmadia, A., Bagshaw, C. R., Nyitray, L. (2004): Engineering lysine reactivity as a conformational sensor in the Dictyostelium myosin II motor domain. J. Muscle Res. Cell Motil. 25: 95-102. 10. Kovács, M., Tóth, J., Hetényi, C., Málnási-Csizmadia, A., Sellers, J. R. (2004): Mechanism of blebbistatin inhibition of myosin II. J. Biol. Chem. 279: 35557-63. 11. Kovács, M., Wang, F., Sellers, J. R. (2005): Mechanism of action of myosin X, a membrane-associated molecular motor. J. Biol. Chem. 280: 15071-15083. 12. Kim, K-Y.*, Kovács, M.*, Kawamoto, S., Sellers, J. R., Adelstein, R. S. (2005): Disease-associated mutations and alternative splicing alter the enzymatic and motile activity of nonmuscle myosins II-B and II-C. J. Biol. Chem. 280: 22769-75. 13. Liu, X., Shu, S., Kovács, M., Korn, E. D. (2005): Biological, biochemical and kinetic effects of mutations of the cardiomyopathy-loop of Dictyostelium myosin II: Importance of Ala400. J. Biol. Chem. 280: 26974- 83. 14. Tóth, J., Kovács, M., Wang, F., Nyitray, L., Sellers, J. R. (2005): Myosin V from Drosophila reveals diversity of motor mechanisms within the myosin V family. J. Biol. Chem. 280: 30594-603. 15. Yang, Y.*, Kovács, M.*, Xu, E., Anderson, J. B., Sellers, J. R. (2005): Myosin VIIB from Drosophila is a high duty ratio motor. J. Biol. Chem. 280: 32061-8. 16. Yang, Y.*, Kovács, M.*, Sakamoto, T.*, Zhang, F., Kiehart, D. P., Sellers, J. R. (2006): Dimerized Drosophila myosin VIIa: a processive motor. Proc. Natl. Acad. Sci. USA 103: 5746-51. 17. Forgács, E., Cartwright, S., Kovács, M., Sakamoto, T., Sellers, J. R., Corrie, J. E., Webb, M. R., White, H. D. (2006): Kinetic mechanism of myosinV-S1 using a new fluorescent ATP analogue. Biochemistry 45:13035-45.

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18. Kintses, B., Simon, Z., Gyimesi, M., Tóth, J., Jelinek, B., Niedetzky, C., Kovács, M., Málnási-Csizmadia, A. (2006): Enzyme kinetics above denaturation temperature: a temperature-jump/stopped-flow apparatus. Biophys J. 91: 4605-10. 19. Yang, Y., Gourinath, S., Kovács, M., Nyitray, L., Reutzel, R., Himmel, D. M., O'Neall-Hennessey, E., Reshetnikova, L., Szent-Györgyi, A. G., Brown, J. H., Cohen, C. (2007): Rigor-like structures of muscle myosins reveal key mechanical elements in the transduction pathways of this allosteric motor. Structure 15: 553-64. 20. Iwamoto, H., Oiwa, K., Kovács, M., Sellers, J. R., Suzuki, T., Wakayama, J., Tamura, T., Yagi, N., Fujisawa, T. (2007): Diversity of structural behavior in vertebrate conventional myosins complexed with actin. J. Mol. Biol. 369: 249-64. 21. Málnási-Csizmadia, A., Tóth, J., Pearson, D. S., Hetényi, C., Nyitray, L., Geeves, M. A., Bagshaw, C. R., Kovács, M. (2007): Selective perturbation of the myosin recovery stroke by point mutations at the base of the lever arm affects ATP hydrolysis and phosphate release. J. Biol. Chem. 282: 17658-64. 22. Kovács, M., Thirumurugan, K., Knight, P. J., Sellers, J. R. (2007): Load-dependent mechanism of non- muscle myosin 2. Proc. Natl. Acad. Sci. USA 104: 9994-9. 23. Tóth, J., Varga, B., Kovács, M., Málnási-Csizmadia, A., Vértessy B. G. (2007): Kinetic mechanism of human dUTPase, as essential nucleotide pyrophosphatase enzyme. J. Biol. Chem. 282: 33572-82. 24. Takagi, Y., Yang, Y., Fujiwara, I., Jacobs, D., Cheney, R. E., Sellers, J. R., Kovács, M. (2008): Human myosin Vc is a low duty ratio, non-processive molecular motor. J. Biol. Chem. 283: 8527-37. 25. Forgacs, E., Sakamoto, T., Cartwright, S., Belknap, B., Kovács, M., Tóth, J., Webb, M. R., Sellers, J. R., White, H. D. (2009): Switch 1 Mutation S217A Converts Myosin V into a Low Duty Ratio Motor. J. Biol. Chem. 284: 2138-49. 26. Gyimesi, M., Sarlós, K., Derenyi, I., Kovács, M. (2010): Streamlined determination of processive run length and mechanochemical coupling of nucleic acid motor activities. Nucleic Acids Res. 38: e102. 27. Takács, B., Billington, N., Gyimesi, M., Kintses, B., Málnási-Csizmadia, A., Knight, P. J., Kovács, M. (2010): Myosin complexed with ADP and blebbistatin reversibly adopts a conformation resembling the start point of the working stroke. Proc. Natl. Acad. Sci. USA 107: 6799-804. 28. Gyimesi, M., Sarlós, K., Kovács, M. (2010): Processive translocation mechanism of the human Bloom’s syndrome helicase along single-stranded DNA. Nucleic Acids Res. 38: 4404-14. 29. Nagy, N., Sakamoto, T., Takács, B., Gyimesi, M., Hazai, E., Bikádi, Z., Sellers, J. R., Kovács, M. (2010): Functional adaptation of the switch-2 nucleotide sensor enables rapid processive translocation by myosin-5. FASEB J. 24: 4480-4490. 30. Málnási-Csizmadia, A., Kovács, M. (2010): Emerging complex pathways of the actomyosin powerstroke. Trends Biochem. Sci. 35: 684-690. 31. Radnai, L., Rapali, P., Hódi, Z., Süveges, D., Molnár, T., Kiss, B., Bécsi, B., Erdődi, F., Buday, L., Kardos, J., Kovács, M., Nyitray, L. (2010): Affinity, avidity and kinetics of target sequence binding to LC8 dynein light chain isoforms. J. Biol. Chem. 285: 38649-38657. 32. Takács, B., O'Neall-Hennessey, E., Hetényi, C., Kardos, J., Szent-Györgyi, A. G., Kovács, M. (2011): Myosin cleft closure determines the energetics of the actomyosin interaction. FASEB J. 25: 111-121. 33. Gyimesi, M., Harami, G. M., Sarlós, K., Hazai, E., Bikádi, Z., Kovács, M. (2012): Complex activities of the human Bloom's syndrome helicase are encoded in a core region comprising the RecA and Zn-binding domains. Nucleic Acids Res. 40: 3952-63. 34. Ma, X.*, Kovács, M.*, Conti, M. A., Wang, A., Zhang, Y., Sellers, J. R., Adelstein, R. S. (2012): Nonmuscle myosin II exerts tension but does not translocate actin in vertebrate cytokinesis. Proc Natl Acad Sci USA 109: 4509-14. 35. Képiró, M., Várkuti, B. H., Bodor, A., Hegyi, G., Drahos, L., Kovács, M.*, Málnási-Csizmadia, A.* (2012): Azidoblebbistatin, a photoreactive myosin inhibitor. Proc Natl Acad Sci USA 109: 9402-7. 36. Sarlós, K., Gyimesi, M., Kovács, M. (2012): RecQ helicase translocates along single-stranded DNA with a moderate processivity and tight mechanochemical coupling. Proc Natl Acad Sci USA 109: 9804-9.

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37. Biedermannova, L., Prokop, Z., Gora, A., Chovancova, E., Kovács, M., Damborsky, J., Wade, R. C. (2012): A single mutation in a tunnel to the active site changes the mechanism and kinetics of product release in haloalkane dehalogenase LinB. J. Biol. Chem. 287: 29062-74. 38. Ujfalusi, Z., Kovács, M., Nagy, N. T., Barko, S., Hild, G., Lukacs, A., Nyitrai, M., Bugyi, B. (2012): Myosin and tropomyosin stabilize the conformation of formin-nucleated actin filaments. J. Biol. Chem. 287: 31894-904. 39. Bibó, A., Kovács, M., Károlyi, G. (2013): Overdamped mechanical model of myosin II. Periodica Polytechnica Civil Engineering, in press 40. Nagy, N. T., Chakraborty,S., Harami, G.M., Sellers, J. R., Sakamoto, T., Kovács, M. (2013): A subdomain interaction at the base of the lever allosterically tunes the mechanochemical mechanism of myosin 5a. PLoS ONE, in press 41. Harami, G.M., Gyimesi, M., Kovács, M. (2013): From keys to bulldozers: expanding roles for winged helix domains in nucleic acid-binding proteins. Trends Biochem. Sci., in press

Book chapters 1. Bibó, A., Kovács, M., Károlyi, G., (2010): Internal lever arm model for myosin II. In: IUTAM Bookseries, Volume 30, Part 5. Springer Verlag, pp. 155-163. ISBN:978-94-007-1643-8 2. Kovács, M., Málnási-Csizmadia, A. (2012): Biophysical approaches that revealed the action of myosin as a molecular machine. In: Molecular Biophysics for the Life Sciences, Springer, in press 3. Kovács, M. (2012): Géntechnológia. In: Bevezetés a biokémiába, Elektronikus jegyzet, ELTE Biológiai Intézet, in press

Articles and interviews in Hungarian 1. Csermely Péter, Málnási-Csizmadia András, Kovács Mihály (2002): Hogyan hozhatnánk haza a külföldön dolgozó, tehetséges fiatal magyar kutatókat? [Ways to recruit talented young Hungarian researchers.] Magyar Tudomány, Dec 2002 2. Nagy távolságra is elmenni – Kovács Mihály biokémikus. [Interview: Traveling long distances.] Szakmák könyve, HVG kiadó, 2006 3. Kovács Mihály (2008): Lassan járj, tovább érsz: a sejtosztódás és differenciáció motorjainak mechanikai szabályozása. [Slowly but steadily: Mechanoregulation of motors of cell division and differentiation.] Biokémia, Dec 2008 4. Takács Balázs, Kovács Mihály (2009): Motorok a sejtben – Mi hajt bennünket? [Motors in the cell – What drives us?] Élet és Tudomány, LXIV/6. 5. Sarlós Kata, Gyimesi Máté, Kovács Mihály (2009): Anyagmozgatás és információ-továbbítás a sejtben: biológiai motorok. [Material transport and information processing in the cell: Biological motors.] Természet Világa, May 2009 6. Képességek kibontakozása a mai Magyarországon. *Interview: Fostering talent in today’s Hungary.] Nemzeti Tehetségsegítő Tanács honlapja, 2009 7. Kalandvágyból építkezni. [Interview: Building on a desire for adventure.] Nyúz (ELTE TTK), Oct 21, 2009 8. Hibajavító fehérjemotorok. [Interview: Protein machines in DNA repair.] OTKA – A hónap kutatója, February 2010 9. Gyimesi Máté, Vellai Tibor, Kovács Mihály (2010): A genetikai állomány stabilitása: helikáz enzimek szerepe a DNS-hibajavításban. [Stability of the genetic material: Role of helicase enzymes in DNA repair.] Természet Világa, March 2010 10. Nagy Nikolett, Takács Balázs, Kovács Mihály (2010): Motorenzimek működési alapelvei és egyedi finomhangolása. [Functional principles and specific fine tuning of motor enzymes.] Biokémia, June 2010 11. A motorenzimek szerepe a rákkutatásban. [Motor enzymes in cancer research.] MTA honlap – A tudomány hírei, July 5, 2011 12. Mozgató enzimek. [Enzymes that make things move.] Figyelő, 55/33. Aug 18-24, 2011

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13. Hibák a DNS-ben. [Interview: Errors in DNA.] ELTE honlap, February 22, 2012 14. Harami Gábor, Gyimesi Máté, Kovács Mihály (2012): A kulcstól a bulldózerig: szárnyas hélix domének funkcionális adaptációja DNS-kötő fehérjékben. *Of keys and bulldozers: Functional adaptation of winged helix domains in DNA-binding proteins.] Biokémia, June 2012 15. Kocsis S. Zsuzsa, Haracska Lajos, Szüts Dávid, Kovács Mihály (2013): DNS-hibajavítás a megkettőződés folyamata során *DNA repair during the process of replication.+ Természet Világa, in press

Interviews in English 1. Mihály Kovács profile interview, Newsletter of the Biophysical Society, January 2013

Media appearances ATV, Jam. Feb 18, 2009 Info Rádió, Talentum. Feb 20, 2009 mr1 Kossuth Rádió, Szonda. Feb 22, 2009 Fúzió Rádió, Délutáni Randevú. Mar 12, 2009 Duna TV, Mentor – Magyar csillagok. Mar 29, 2009 mr1 Kossuth Rádió, Esti beszélgetés tudományról. Apr 17, 2009 m1 TV, Delta. Oct 22, 2011 m1 TV, Delta. Apr 14, 2012

Conference abstracts *: invited lectures

1. *Kovács, M., Málnási-Csizmadia, A., Woolley, R. J., Bagshaw, C. R. (2001): Identification of tryptophan residues sensitive to nucleotide binding to Dictyostelium myosin II motor domain. 10th Workshop on Molecular Motors, Alpbach, Austria 2. Málnási-Csizmadia, A., Woolley, R. J., Kovács, M., Bagshaw, C. R. (2001): Resolution of conformational states of Dictyostelium myosin II motor domain using tryptophan (W501) mutants. 10th Workshop on Molecular Motors, Alpbach, Austria 3. Kovács, M., Málnási-Csizmadia, A., Woolley, R. J., Bagshaw, C. R. (2001): A miozin ATPáz szerkezeti és kinetikai állapotainak megfeleltetése triptofán-mutáns motor domén konstrukciók segítségével. Annual Meeting of the Hungarian Biochemical Society, Sárospatak, Hungary 4. *Kovács, M., Málnási-Csizmadia, A., Woolley, R. J., Bagshaw, C. R. (2001): Kinetic characterisation of nucleotide binding to myosin mutants containing a single tryptophan near the active site. 30th European Muscle Conference, Pavia, Italy 5. Málnási-Csizmadia, A., Pearson, D. S., Kovács, M., Woolley, R. J., Geeves, M. A., Bagshaw, C. R. (2001): Direct evidence that the open-closed transition and ATP hydrolysis are separate steps in the myosin mechanism. 30th European Muscle Conference, Pavia, Italy 6. Málnási-Csizmadia, A., Woolley, R. J., Tóth, J., Nyitray, L., Bagshaw, C. R., Kovács, M. (2002): Fine tuning of ATP hydrolysis rate by subdomain interactions in myosin. 46th Annual Meeting of the Biophysical Society, San Francisco, CA, USA 7. Kovács, M., Málnási-Csizmadia, A., Woolley, R. J., Bagshaw, C. R. (2002): Precise resolution of myosin nucleotide binding process. 46th Annual Meeting of the Biophysical Society, San Francisco, CA, USA 8. Málnási-Csizmadia, A., Kovács, M., Fajer, P. G., Conibear, P. B., Woolley, R. J., Bagshaw, C. R. (2003): Probes of the myosin cleft that sense actin binding. 47th Annual Meeting of the Biophysical Society, San Antonio, TX, USA 9. Kovács, M., Wang, F., Hu, A., Limouze, J., Sellers, J. R. (2003): Kinetic mechanism of human non-muscle myosin II isoforms. 47th Annual Meeting of the Biophysical Society, San Antonio, TX, USA

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10. Kovács, M., Wang, F., Hu, A., Limouze, J., Sellers, J. R. (2003): Functional divergence of human non- muscle myosin II isoforms. 1st Annual Fellows Retreat of the National Heart, Lung and Blood Institute, Washington, DC, USA 11. Rodgers, P., Okoh, J., Sellers, J. R., Kovács, M. (2003): Engineering of a Single-Headed Myosin II-C Construct in pFastBac Vector for Kinetic Characterization. 3rd Annual Biomedical Research Conference for Minority Students, San Diego, CA, USA 12. Kovács, M., Tóth, J., Sellers, J. R. (2003): Two-headed actin binding of the unphosphorylated non- muscle myosin IIA-ADP complex. 43rd Annual Meeting of the American Society for Cell Biology, San Francisco, CA, USA 13. *Kovács, M., Tóth, J., Sellers, J. R. (2004): Blebbistatin alters actin and nucleotide interaction of myosin II in a unique manner. 48th Annual Meeting of the Biophysical Society, Baltimore, MD, USA 14. *Kovács, M., Tóth, J., Hetényi, C., Málnási-Csizmadia, A., Sellers, J. R. (2004): Blebbistatin alters actin and nucleotide interaction of myosin II in a unique manner. 11th Workshop on Molecular Motors, Alpbach, Ausztria 15. Málnási-Csizmadia, A., Kovács, M. (2004): Mi határozza meg az enzimreakciók sebességét? Annual Meeting of the Hungarian Biochemical Society, Sopron, Hungary 16. Kim, K. Y., Preston, Y. A., Kovács, M., Harvey, E. V., Sellers, J. R., Adelstein, R. S (2004): Characterization of the enzymatic function of nonmuscle heavy meromyosin II-B and II-C. 2nd Annual Fellows Retreat of the National Heart, Lung and Blood Institute, Warrenton, VA, USA 17. *Kovács, M., Wang, F., Sellers, J. R. (2004): Unique mechanism of action of myosin-X, a membrane motor. 2nd Annual Fellows Retreat of the National Heart, Lung and Blood Institute, Warrenton, VA, USA 18. Kovács, M., Wang, F., Sellers, J. R. (2004): Unique mechanism of action of myosin-X, a membrane motor. 33rd European Muscle Conference, Isola d’Elba, Italy 19. Kovács, M., Wang, F., Sellers, J. R. (2004): Unique mechanism of action of myosin-X, a membrane motor. NIH Research Festival, Bethesda, MD, USA 20. Kovács, M., Wang, F., Sellers, J. R. (2004): Unique mechanism of action of myosin-X, a membrane motor. 44th Annual Meeting of the American Society for Cell Biology, Washington, DC, USA 21. Kim, K. Y., Kovács, M., Preston, Y. A., Harvey, E. V., Kawamoto, S., Sellers, J. R., Adelstein, R. S. (2004): Mutations in nonmuscle myosin heavy chain II-B and II-C associated with diseases result in the impairment of enzymatic activity. 44th Annual Meeting of the American Society for Cell Biology, Washington, DC, USA 22. Kovács, M., Wang, F., Tóth, J., Hu, A., Limouze, J., Sellers, J. R. (2005): Functional diversity of non- muscle myosin II isoforms. 49th Annual Meeting of the Biophysical Society, Long Beach, CA, USA 23. *Kovács, M., Wang, F., Sellers, J. R. (2005): Mechanism of action of the membrane motor myosin X. 49th Annual Meeting of the Biophysical Society, Long Beach, CA, USA 24. *Kovács, M., Wang, F., Sellers, J. R. (2005): Load-dependent kinetics of non-muscle myosin II. 3rd Annual Fellows Retreat of the National Heart, Lung and Blood Institute, St. Michaels, MD, USA 25. Tóth, J., Kovács, M., Wang, F., Sellers, J. R. (2005): Drosophila myosin V: solution kinetics and motile properties. 3rd Annual Fellows Retreat of the National Heart, Lung and Blood Institute, St. Michaels, MD, USA 26. Tóth, J., Kovács, M., Wang, F., Nyitray, L., Sellers, J. R. (2005): Drosophila myosin V: solution kinetics and motile properties. 30th FEBS Congress - 9th IUBMB Conference, Budapest, Hungary 27. *Kovács, M., Wang, F., Thirumurugan, K., Knight, P. J., Sellers, J. R. (2005): Load-dependent kinetics of non-muscle myosin II. Gordon Research Conference on Muscle and Contractile Proteins, New London, NH, USA 28. *Kovács, M., Sellers, J. R. (2005): All myosins are unconventional. International Conference on Motor Proteins and the Cytoskeleton, Hamburg, Germany 29. Yang, Y., Kovács, M., Sakamoto, T., Kiehart, D. P., Sellers, J. R. (2006): Drosophila myosin VIIa is a processive motor. 50th Annual Meeting of the Biophysical Society, Salt Lake City, UT, USA

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30. Iwamoto, H., Oiwa, K., Uyeda, T.Q.P., Kovács, M., Sellers, J. R., Wakayama, J., Tamura, T., Fujisawa, T., Yagi, N (2006): Low-Resolution Structures of Complexes between Actin and Myosin-II Subfragments from Muscle and Non-muscle Sources as Studied by X-ray Diffraction. 50th Annual Meeting of the Biophysical Society, Salt Lake City, UT, USA 31. *Kovács, M., Thirumurugan, K., Knight, P. J., Sellers, J. R. (2006): Load-dependent kinetics of non- muscle myosin II. Meeting of EMBO Young Investigators, Bécs, Austria 32. Kovács, M., Thirumurugan, K., Knight, P. J., Sellers, J. R. (2006): Load-dependent kinetics of non- muscle myosin II. EMBO/HHMI Central European Meeting, Dubrovnik, Croatia 33. *Kovács, M., Thirumurugan, K., Knight, P. J., Sellers, J. R. (2006): Load-dependent kinetics of non- muscle myosin II. Scientific Meeting of International Research Scholars of the Howard Hughes Medical Institute, Ashburn, VA, USA 34. Németh, A., Süveges, D., Kovács, M., Nyitray, L. (2006): Kinetic investigation of myosin regulation. Annual Meeting of the Hungarian Biochemical Society, Pécs, Hungary 35. *Takács, B., Gyimesi, M., Kintses, B., Málnási-Csizmadia, A., Kovács, M. (2007): Blebbistatin alters nucleotide-induced structural changes in myosin. 51st Annual Meeting of the Biophysical Society, Baltimore, MD, USA 36. Forgacs, E., Cartwright, S., Kovács, M., Tóth, J., Conyers, B., Tribby, M., Webb, M. R., Corrie, J. E. T., Sellers, J. R., White, H. D. (2007): Mutational analysis of the myosinV active site. 51st Annual Meeting of the Biophysical Society, Baltimore, MD, USA 37. Végner, L., Kintses, B., Kovács, M., Málnási-Csizmadia, A. (2007): Heat induced protein unfolding initiated in low-stability “hot regions”. 51st Annual Meeting of the Biophysical Society, Baltimore, MD, USA 38. Gyimesi, M., Kintses, B., Simon, Z., Tóth, J., Jelinek, B., Niedetzky, C., Kovács, M., Málnási-Csizmadia, A. (2007): Enzyme kinetics above denaturation temperature: a temperature-jump/stopped-flow apparatus. FEBS Young Scientist Forum, Vienna, Austria 39. Nagy, N., Kovács, M. (2007): Role of the switch-2 active site loop in the processive mechanism of myosin 5. Molecular Recognition Conference, Pécs, Hungary 40. *Sarlós, K., Thirumurugan, K., Knight, P. J., Sellers, J. R., Kovács, M. (2007): Load-dependent mechanism of non-muscle myosin 2 enables highly efficient functioning. Molecular Recognition Conference, Pécs, Hungary 41. Sarlós, K., Málnási-Csizmadia, A., Kovács, M. (2007): Effect of mechanical load on the kinetics and thermodynamics of a motor enzyme reaction. Molecular Recognition Conference, Pécs, Hungary 42. Végner, L., Simon, Z., Kovács, M., Málnási-Csizmadia, A. (2007): Enzyme kinetics above denaturation temperature: a temperature-jump/stopped-flow apparatus. Molecular Recognition Conference, Pécs, Hungary 43. *Sarlós, K., Thirumurugan, K., Knight, P. J., Sellers, J. R., Kovács, M. (2007): Terhelés-függő mechanizmus teszi lehetővé a nem-izom miozin 2 hatékony működését. Annual Meeting of the Hungarian Biochemical Society, Debrecen 44. Takács, B., Gyimesi, M., Kintses, B., Málnási-Csizmadia, A., Kovács, M. (2007): Blebbistatin hatása a miozin szerkezetváltozásaira. Annual Meeting of the Hungarian Biochemical Society, Debrecen, Hungary 45. Nagy, N., Kovács, M. (2007): A switch-2 aktívhely hurok szerepe a miozin 5 processzív működésében. Annual Meeting of the Hungarian Biochemical Society, Debrecen, Hungary 46. Tóth, J., Varga, B., Kovács, M., Málnási-Csizmadia, A., Vértessy, B. (2007): A humán dUTPáz enzimatikus mechanizmusa. Annual Meeting of the Hungarian Biochemical Society, Debrecen, Hungary 47. *Sarlós, K., Thirumurugan, K., Knight, P. J., Sellers, J. R., Kovács, M. (2007): Load-dependent mechanism of non-muscle myosin 2 enables highly efficient functioning. European Muscle Conference, Stockholm, Sweden 48. *Nagy, N., Sellers, J. R., and Kovács, M. (2008): Role of the switch-2 active site loop in the processive mechanism of myosin 5. Annual Meeting of the Biophysical Society, Long Beach, CA, USA

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49. Veigel, C., Schmitz, S., Takagi, Y., Kovács, M., and Sellers, J. R. (2008): Force generation by non-muscle myosin 2A measured by optical tweezers. Annual Meeting of the Biophysical Society, Long Beach, CA, USA 50. Takagi, Y., Yang, Y., Fujiwara, I., Jacobs, D., Cheney, R. E., Kovács, M., and Sellers, J. R. (2008): Human myosin Vc is a low duty ratio, non-processive molecular motor. Annual Meeting of the Biophysical Society, Long Beach, CA, USA 51. Forgacs, E., Cartwright, S., Sakamoto, T., Belknap, B., Conyers, B., Tribby, M., Kovács, M., Tóth, J., Sellers, J. R., Webb, M. R., White, H. D. (2008): The effect of switch-1 mutation Ser217Ala on the kinetics of production dissociation and motor function of myosin V. 52nd Annual Meeting of the Biophysical Society, Long Beach, CA, USA 52. *Nagy, N., Sarlós, K., Takács, B., Tóth, J., Yang, Y., Pearson, D. S., Hetényi, C., Nyitray, L., Málnási- Csizmadia, A., Geeves, M. A., Bagshaw, C. R., Sellers, J. R., Brown, J. H., Szent- Györgyi, A. G., Cohen, C., Kovács, M. (2008): Routes of allosteric communication between functional parts of the myosin motor. Meeting of International Research Scholars of the Howard Hughes Medical Institute, Lisszabon, Portugal 53. *Takács, B., Gyimesi, M., Kintses, B., Málnási-Csizmadia, A., Kovács, M. (2008): Blebbistatin alters nucleotide-induced structural changes in myosin. Gordon Research Conference on Muscle and Molecular Motors, New London, NH, USA 54. Takács, B., O’Neall-Hennessey, E., Szent-Györgyi, A. G., Kovács, M. (2008): Miozin-2 izoformák eltérő aktinkötő tulajdonságai. Annual Meeting of the Hungarian Biochemical Society, Szeged, Hungary 55. Sarlós, K., Málnási-Csizmadia, A., Kovács, M. (2008): Mechanikai terhelés hatása egy enzimreakció kinetikájára. Annual Meeting of the Hungarian Biochemical Society, Szeged, Hungary 56. Gyimesi, M., Kovács, M. (2008): A humán BLM helikáz működési mechanizmusa. Annual Meeting of the Hungarian Biochemical Society, Szeged, Hungary 57. *Takács, B., Gyimesi, M., Kintses, B., Málnási-Csizmadia, A., Kovács, M. (2008): Utility of a myosin inhibitor in deciphering the structural mechanism of force generation. Chemistry towards Biology Conference, Dobogókő, Hungary 58. *Takács, B., Gyimesi, M., Kintses, B., Málnási-Csizmadia, A., Kovács, M. (2008): Blebbistatin alters nucleotide-induced structural changes in myosin. European Muscle Conference, Oxford, U.K. 59. Nagy, A., Takagi, Y., Homsher, E., Kovács, M., Sellers, J. R. (2008): Single molecule kinetic measurements of non-muscle myosin IIB using optical tweezers. 48th Annual Meeting of the American Society for Cell Biology, San Francisco, CA, USA 60. Gyimesi, M., Sarlós, K., Kovács, M. (2009): Working mechanism of the human Bloom’s syndrome helicase. 53rd Annual Meeting of the Biophysical Society, Boston, MA, USA 61. Nagy, A., Takagi, Y., Homsher, E., Kovács, M., Sellers, J. R. (2009): Single molecule kinetic measurements of non-muscle myosin IIB using optical tweezers. 53rd Annual Meeting of the Biophysical Society, Boston, MA, USA 62. *Gyimesi, M., Sarlós, K., Kovács, M. (2009): Mechanism of translocation of the BLM helicase along DNA. Central-Eastern European INSTRUCT Meeting, Budapest, Hungary 63. *Gyimesi, M., Sarlós, K., Kovács, M. (2009): Mechanism of translocation of the BLM helicase along DNA. EMBO Young Investigator Meeting, Istanbul, Turkey 64. *Gyimesi, M., Sarlós, K., Kovács, M. (2009): Processive translocation mechanism of the human Bloom’s syndrome helicase along single-stranded DNA. EMBO Meeting on Helicases and Nucleic Acid Machines, Les Diablerets, Switzerland 65. Sarlós, K., Gyimesi, M., Kovács, M. (2009): Mechanism of DNA-dependent enzymatic activation of Escherichia coli RecQ helicase. EMBO Meeting on Helicases and Nucleic Acid Machines, Les Diablerets, Switzerland 66. Nagy, N., Sakamoto, T., Takács, B., Gyimesi, M., Sellers, J. R., Kovács, M. (2009): A class-specific structural adaptation of the switch-2 loop enables rapid processive translocation of myosin 5a. European Muscle Conference, Lille, France

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67. Takacs, B., O'Neall-Henessey, E., Hetenyi, C., Kardos, J., Szent-Györgyi, A. G., Kovács, M. (2009): Myosin cleft closure determines the energetics of the actomyosin interaction. European Muscle Conference, Lille, France 68. Gyimesi, M., Sarlós, K., Kovács, M. (2009): A humán Bloom szindróma helikáz processzív transzlokációs mechanizmusa. Annual Meeting of the Hungarian Biochemical Society, Budapest, Hungary 69. Sarlós, K., Gyimesi, M., Kovács, M. (2009): A DNS-függő enzimaktiváció szerepe a RecQ helikáz működésében. Annual Meeting of the Hungarian Biochemical Society, Budapest, Hungary 70. Takács, B., Billington, N., Gyimesi, M., Kintses, B., Málnási-Csizmadia, A., Knight, P. J., Kovács, M. (2009): A blebbistatin stabilizálja a miozin erőgeneráló lépésének kezdőállapotát. Annual Meeting of the Hungarian Biochemical Society, Budapest, Hungary 71. Sarlós, K., Gyimesi, M., Kovács, M. (2010): Mechanism of DNA-dependent enzymatic activation of Escherichia coli RecQ helicase. 54th Annual Meeting of the Biophysical Society, San Francisco, CA, USA 72. Nagy, A., Takagi, Y., Homsher, E. E., Hong, D. K. T., Kovács, M., Sellers, J. R. (2010): Kinetic characterization of non-muscle myosin IIB single-headed heavy meromyosin on single molecule level with optical tweezers. 54th Annual Meeting of the Biophysical Society, San Francisco, CA, USA 73. *Takács, B., O'Neall-Henessey, E., Hetényi, C., Kardos, J., Szent-Györgyi, A. G., Kovács, M. (2010): Myosin cleft closure determines the energetics of the actomyosin interaction. Conference on Muscle and Many other Motors, Alpbach, Austria 74. Gyimesi, M. Sarlós, K., Harami, G., Kocsis, Z., Kovács, M. (2010): Deciphering the mechanochemistry of RecQ-family DNA helicases. EMBO DNA Repair Meeting, Brno, Czech Republic 75. Bibó, A., Kovács, M., Károlyi, Gy. (2010): Internal lever arm model for myosin II. IUTAM Symposium on Dynamics Modeling and Interaction Control in Virtual and Real Environments, Budapest, Hungary 76. Gyimesi, M., Pires, R. H., Sarlós, K., Módos, K., Kellermayer, M. S., Kovács, M. (2010): The role of substrate induced oligomerization in the working mechanism of the human Bloom’s syndrome DNA helicase (BLM). Annual Meeting of the Hungarian Biochemical Society, Budapest, Hungary 77. *Kovács, M. (2010): Helikáz enzimek: a nukleinsavak szerkezet-átalakító motorjai. Mennyire rugalmasak a fehérjék? – Az MTA Biológiai Osztályának előadóülése, Magyar Tudományos Akadémia, Budapest 78. Gyimesi, M., Sarlós, K., Kovács, M. (2011): Two RecA domains comprise a minimal functional unit of the human BLM helicase. 55th Annual Meeting of the Biophysical Society, Baltimore, MD, USA 79. Nagy, N. T., Kovács, M. (2011): Allosteric tuning of myosin 5a motor activity. 55th Annual Meeting of the Biophysical Society, Baltimore, MD, USA 80. Sarlós, K., Gyimesi, M., Neuman, K.C., Kovács, M. (2011): Mechanochemistry of DNA helicases. HFSP Meeting, Montreal, Canada 81. Sarlós, K., Gyimesi, M., Neuman, K.C., Kovács, M. (2011): Temperature-dependent switch in the mechanochemical activity of RecQ helicases. Central European Meeting on Genome Stability and Dynamics, Bratislava, Slovakia 82. Gyimesi, M., Harami, G., Sarlós, K., Kovács, M. (2011): Basic homologous recombination activities can be performed by the minimal core of Bloom's syndrome helicase. Central European Meeting on Genome Stability and Dynamics, Bratislava, Slovakia 83. Kocsis, Z. S., Pintér, L., Haracska, L., Kovács, M. (2011): Non-canonical helicase in DNA repair. TÁMOP Meeting, Dobogókő, Hungary 84. Sarlós, K., Gyimesi, M., Kovács, M. (2011): Harnessing of chemical energy for mechanical work in DNA- restructuring enzymes. TÁMOP Meeting, Dobogókő, Hungary 85. *Gyimesi, M., Sarlós, K., Harami, G., Kocsis, Z. S., Pires, R. H., Módos, K., Derényi, I., Kellermayer, M., Kovács, M. (2011): Stability and variability: genome-maintaining activities of DNA-restructuring motor enzymes. TÁMOP Meeting, Dobogókő, Hungary 86. Harami, G., Gyimesi, M., Sarlós, K., Kovács, M. (2011): Functional anatomy of the human Bloom’s syndrome helicase. FASEB Helicase Meeting, Steamboat Springs, CO, USA

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87. Sarlós, K., Gyimesi, M., Pires, R. H., Módos, K., Kellermayer, M. S. Z., Kovács, M. (2011): Dynamic switch between assembly states of the human Bloom’s syndrome helicase during homologous recombination. FASEB Helicase Meeting, Steamboat Springs, CO, USA 88. Kocsis, Z. S., Pintér, L., Haracska, L., Kovács, M. (2011): ATPase properties of a non-canonical helicase. FASEB Helicase Meeting, Steamboat Springs, CO, USA 89. *Kovács, M. (2011): Stability and variability: genome-maintaining activities of DNA-restructuring motor enzymes. 25th Anniversary of the Hungarian Scientific Research Fund (OTKA), Budapest, Hungary 90. Bibó, A., Károlyi, G., Kovács, M. (2011): Internal lever arm model for myosin II. Biochemical Society/Wellcome Trust Focused Meeting on Cellular cytoskeletal motor proteins, Hinxton, Cambridge, UK 91. Bibó, A., Károlyi, G., Kovács, M. (2011): Internal lever arm model for myosin II. Gordon Research Conference on Muscle & Molecular Motors, New London, NH, USA 92. *Gyimesi, M., Harami, G., Sarlós, K., Roy, D., Kovács, M. (2011): Bloom’s syndrome helicase: functional anatomy of a DNA-restructuring motor protein. Annual Meeting of the Hungarian Biochemical Society, Pécs, Hungary 93. Kocsis, Z. S., Pintér, L., Haracska, L., Kovács, M. (2011): ATPase properties of a non-canonical helicase. Annual Meeting of the Hungarian Biochemical Society, Pécs, Hungary 94. Harami, G., Gyimesi, M., Sarlós, K., Kovács, M. (2011): Enzymatic processes in DNA repair: Genome maintaining activities of RecQ helicases. 4th European Conference on Chemistry for Life Sciences, Budapest, Hungary 95. Nagy, N. T., Chakroborty, S., Sakamoto, T., Kovács, M. (2011): Allosteric tuning of myosin 5a motor activity. European Muscle Conference, Berlin, Germany 96. *Málnási-Csizmadia, A., Kovács, M. (2011): Emerging complex pathways of the actomyosin powerstroke. European Muscle Conference, Berlin, Germany 97. Képiró, M., Várkuti, B., Bodor, A., Drahos, L., Hegyi, G., Kovács, M., Málnási-Csizmadia, A. (2011): Synthesis and functional characterization of azido-blebbistatin, a photoreactive myosin inhibitor. European Muscle Conference, Berlin, Germany 98. Ma, X., Kovács, M., Adelstein, R. S. (2011): Nonmuscle myosin II drives contractile ring constriction by exerting tension on but not translocating actin-filaments. Annual Meeting of the American Society for Cell Biology, Denver, CO, USA 99. Kocsis, Z. S., Pintér, L., Haracska, L., Kovács, M. (2012): Mechanochemistry of the Rad5 double- stranded DNA translocase. 56th Annual Meeting of the Biophysical Society, San Diego, CA, USA 100. Harami, G., Gyimesi, M., Kovács, M. (2012): Mechanism of D-loop disruption by the human Bloom’s syndrome helicase. 56th Annual Meeting of the Biophysical Society, San Diego, CA, USA 101. Gyimesi, M., Pires, R. H., Sarlós, K., Nagy, N. T., Módos, K., Kellermayer, M. S. Z., Kovács, M. (2012): Dynamic switch between assembly states of the human Bloom’s syndrome helicase during homologous recombination. 56th Annual Meeting of the Biophysical Society, San Diego, CA, USA 102. *Gyimesi, M., Harami, G., Pires, R. H., Sarlós, K., Hegyi, G., Módos, K., Kellermayer, M. S., Kovács, M. (2012): Mechanism of regulation of homologous recombination by the human Bloom’s syndrome helicase. FEBS3+ Meeting, Opatija, Croatia 103. Kocsis, Z. S., Pintér, L., Haracska, L., Kovács, M. (2012): Mechanochemistry of the Rad5 double- stranded DNA translocase. FEBS3+ Meeting, Opatija, Croatia 104. Biedermannová, L., Prokop, Z., Gora, A., Chovancová, E., Kovács, M., Damborský, J., Wade, R. C. (2012): Study of transport processes of ligands in protein structures. ENBIK - National Bioinformatics Conference, Český Šternberk, Czech Republic 105. Harami, G., Gyimesi, M., Sarlós, K., Kocsis, Z. S., Nagy, N. T., Ferencziová, V., Kovács, M. (2012): Kommunikációs útvonalak DNS-kötő fehérjékben: A RecQ helikázok szerepe a genomkarbantartó folyamatokban. TÁMOP Konferencia, Dobogókő 106. Kocsis Z. S., Harami, G., Gyimesi, M., Kovács, M. (2012): Bepillantás a RecQ molekulán belüli mozgásokba. TÁMOP Konferencia, Dobogókő

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107. *Kovács, M. (2012): DNS-hibajavító motorfehérjék. Kiemelkedő biológiai kutatások – Eötvös-napi előadóülés, Eötvös Loránd Tudományegyetem, Budapest 108. *Kovács, M. (2012): DNS helikázok doménjeinek táncrendje. A fehérjék „lélektana”: rend a lelke mindennek? – Az MTA Biológiai Osztályának előadóülése, Magyar Tudományos Akadémia, Budapest 109. Képiró, M., Várkuti, B. H., Hegyi, G., Kovács, M., Málnási-Csizmadia, A. (2013): Interactomics of blebbistatin. Annual Meeting of the Biophysical Society, Philadelphia, PA, USA 110. Sun, Y., In, J., Seol, Y., Sarkar, S., Strub, M., Sarlós, K., Kovács, M., Neuman, K. C. (2013): Sequence- specific pausing of RecQ helicase. Annual Meeting of the Biophysical Society, Philadelphia, PA, USA 111. Kocsis, Z. S., Harami, G. M., Sun, Y., In, J., Seol, Y., Sarkar, S., Strub, M-P., Sarlós, K., Neuman, K. C., Kovács, M. (2013): Domain Movements and Sequence-specific Pausing of RecQ Helicase. Hungarian Molecular Life Sciences Conference, Siófok, Hungary 112. Kocsis, Z. S., Harami, G. M., Sun, Y., In, J., Seol, Y., Sarkar, S., Strub, M-P., Sarlós, K., Neuman, K. C., Kovács, M. (2013): Domain Movements and Sequence-specific Pausing of RecQ Helicase. Student Scientific Conference on Biotechnology and Biomedicine, Brno, Czech Republic 113. Sun, Y., In, J., Seol, Y., Sarkar, S., Strub, M., Harami, G., Sarlós, K., Kovács, M., Neuman, K. C. (2013): Sequence-specific pausing of RecQ helicase. HFSP Meeting, Strasbourg, France

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