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Mihály Kovács Mihály Kovács Curriculum vitae Mihály Kovács Mihály Kovács Date of birth: 23/08/1975 Current position: Associate Research Professor, Principal Investigator (2005-) ELTE-MTA “Momentum” Motor Enzymology Research Group (2011-) Department of Biochemistry, Institute of Biology, Eötvös Loránd University (ELTE) 1117 Budapest, Pázmány Péter sétány 1/C, Hungary Tel.: +36-1-372-2500/8401 Fax: +36-1-381-2172 Email: [email protected] Web: www.mk-lab.org Education, degrees M.Sc. (Biology, ELTE, 1998) Ph.D. (Structural Biochemistry, summa cum laude, ELTE, 2002) Postdoctoral training (National Institutes of Health (NIH) (USA), 2002-2005) Habilitation (Biology, ELTE, 2008) D.Sc. (Hungarian Academy of Sciences (MTA), 2012) Languages Hungarian (native) English (fluent) German (intermediate) Fellowships EMBO Fellowship (Max-Planck-Inst. for Medical Research, Heidelberg, 1998) Hungarian State Eötvös Fellowship (Univ. of Leicester, 2000) EMBO Fellowship (Univ. of Leicester, 2001) NIH Visiting Fellowship (NIH, 2002-2005) Bolyai Fellowship (final evaluation: outstanding) (ELTE-MTA, 2006-2009) Bolyai Fellowship (ELTE-MTA, 2010-2013) Prizes Student Excellence Award (ELTE, 1998) Lenfant Biomedical Fellowship Award (NIH, 2004-2005) Fellows Award for Outstanding Research (NIH, 2004) Fellows Award for Research Excellence (NIH, 2004) Sigma-Aldrich Award, 1st Prize (Sigma-Aldrich Hungary, 2008) Talentum Prize (MTA, 2009) Ignaz L. Lieben Prize (Austrian Academy of Sciences, 2011) Faculty of 1000 Evaluation (2012) Orloff Science Award (NIH, 2013) Scientometry International peer-reviewed articles: 41 First authorship: 12 Last authorship: 13 Corresponding authorship: 16 Cumulative impact factor: 260.025 page 1 of 15 Curriculum vitae Mihály Kovács Total citations: 1306/1005/1048 (Google Scholar/Web of Science/mtmt) Independent citations: 1171/902/803 (Google Scholar/Web of Science/mtmt) H-index: 17/16/16 (Google Scholar/Web of Science/mtmt) Book chapters: 3 Articles and interviews in Hungarian: 15 Interviews in English: 1 Conference abstracts: 113 Research grant support (as Principal Investigator) NIH Global Health Research Initiative (ELTE, 2005-2010, 203 kEUR) EMBO-HHMI Startup (ELTE, 2006-2008, 168 kEUR) OTKA Basic Research (ELTE, 2008-2012, 86 kEUR) OTKA-Norway Fund (ELTE, 2009-2011, 89 kEUR) OTKA-Norway Fund (ELTE, 2011-2012, 36 kEUR) HFSP Research Grant (ELTE, 2010-2013, 340 kEUR) MTA “Momentum” Program (ELTE, 2011-2016, 514 kEUR) Total as PI: 1,436 kEUR Research grant support (as participant) OTKA Basic Research (ELTE, 2005-2009) OTKA Basic Research (ELTE, 2010-2013) EU TÁMOP (ELTE, 2010-2012) EU FP7 Marie Curie IOF (ELTE, coordinator, 2012-2014) OTKA Basic Research (ELTE, 2013-2016) Invited lectures Functional adaptations of non-muscle myosin II (Eastern Virginia Medical School (EVMS), 2004) Mechanism of inhibition of myosin II by blebbistatin (EVMS, 2004) Action and inhibition of cytoplasmic myosin II (Hannover Medical School, 2006) Deciphering the mechanochemistry of RecQ-family DNA helicases (Masaryk University, 2010) Molecular motors in the cytoplasm and in the nucleus (Vellore Institute of Technology (VIT), 2010) In addition, 32 invited conference lectures (marked * in Conference abstracts) Research interest Effect of mechanical load on biochemical processes Mechanisms of force production by motor enzymes (myosins, DNA helicases) Biochemical basis of motor function; functional adaptations of motors to cellular roles Effects of disease-causing mutations on the mechanoenzymatic function of myosins and helicases Small-molecule inhibitors of molecular motors Mechanisms of action and genome-maintaining roles of DNA helicases Technical experience Molecular biology, nucleic acid manipulation, cloning, mutagenesis, cell culture, recombinant protein expression Protein purification, chemical modification of biomolecules, protein chemistry Steady-state and time-resolved fluorescence spectroscopy Steady-state and transient enzyme kinetics: rapid mixing (stopped-flow, quenched-flow) and relaxation methods (temperature-jump, pressure-jump, flash photolysis) Computational kinetic and structural modeling page 2 of 15 Curriculum vitae Mihály Kovács Single molecule fluorescence, motility and force spectroscopic assays DNA binding, unwinding and annealing assays Conference chairmanship Biophysical Society (USA) (BPS) Meeting (Unconventional myosins, 2005) BPS Meeting (Myosin and myosin-family proteins, 2007) BPS Meeting (Myosin and myosin-family proteins, 2008) Hungarian Biochemical Society Meeting (Protein machines, 2009) European Muscle Conference (Contractile actin-myosin interactions, 2011) BPS Meeting (Motility subgroup, 2013) Teaching B.Sc. level Biochemistry and molecular biology (practicals, ELTE, 1998-2002; 2005-) Biochemistry and molecular biology (lectures, ELTE, 2012-) M.Sc. level PCR techniques (practicals, ELTE, 2000) Recombinant DNA (practicals, ELTE, 2000-2002; 2006-) Motor proteins (lectures, ELTE, 2006-) Biochemistry and molecular biology (lectures, ELTE, 2008-) Biophysics (lectures, MAFIHE International Summer School in Physics, 2009) Protein Science (lectures, ELTE, 2010-) Bioregulation (lectures, BME, 2013-) Ph.D. level Motor proteins (lectures, NIH, 2003-2005) Transient enzyme kinetics (lectures, EVMS, 2004) Fluorescence spectroscopy (practicals, ELTE, 2005-) Transient enzyme kinetics (lectures and practicals, ELTE, 2006-) Transient enzyme kinetics (lectures and practicals, FEBS Practical Course on Structure, Folding and Dynamics of Proteins and Their Complexes, 2009) 21st-century Enzymology (lectures, 4th European Conference on Chemistry for Life Sciences, 2011) Degree advisorship B.Sc.: 3 completed Judit Szabó (ELTE, 2009) Judit Gervai (ELTE, 2010) Eszter Molnár (ELTE, 2010) M.Sc.: 9 completed, 1 ongoing (*) Judit Tóth (ELTE, 2002) Patrick Rodgers (NIH, 2003) Nikolett Nagy (ELTE, 2008) Kata Sarlós (ELTE, 2008) Hajnalka Sarankó (ELTE, 2009) Gábor Harami (ELTE, 2010) Debasish Roy (ELTE-VIT, 2011) Judit Gervai (ELTE, 2012) Eszter Molnár (ELTE, 2012) Máté Martina (ELTE, 2013*) page 3 of 15 Curriculum vitae Mihály Kovács Ph.D.: 4 completed, 4 ongoing (*) Judit Tóth (ELTE-NIH, 2006) Balázs Takács (ELTE, 2011) Kata Sarlós (ELTE, 2012) András Bibó (BME, 2013) Nikolett Nagy (ELTE, 2013*) Zsuzsa Kocsis (ELTE, 2013*) Gábor Harami (ELTE, 2013*) Veronika Ferencziová (ELTE, 2015*) Postdoctoral Máté Gyimesi (ELTE, 2007-2012) Achievements of mentees Prizes at National Student Conferences Kata Sarlós (3rd Prize, 2007) Máté Martina (1st Prize, 2013) Prizes at ELTE Student Conferences Kata Sarlós (1st Prize, 2006) Nikolett Nagy (2nd Prize, 2007) Gábor Harami (1st Prize, 2010) Máté Martina (3rd Prize, 2012) Participation at ELTE Student Conferences Judit Gervai (2011) Eszter Molnár (2011) ELTE Student Excellence Awards Judit Tóth (2002) Kata Sarlós (2008) Gábor Harami (2010) Other Prizes Kata Sarlós (Poster Prize at Molecular Recognition Conference, 2007) Máté Gyimesi (Prize of the Hungarian Biochemical Society, 2010) Kata Sarlós (Prize of the Hungarian Biochemical Society, 2013) Fellowships Kata Sarlós (EMBO Fellowship, 2011) Máté Gyimesi (EU FP7 Marie Curie International Outgoing Fellowship, 2012) Zsuzsa Kocsis (Jedlik Ányos Predoctoral Fellowship, National Excellence Program, 2013) Present career of lab alumni Balázs Jelinek (research manager, 2005-2009) Málnási-Csizmadia group, Eötvös University Hajnalka Sarankó (M.Sc., 2009) Hegedűs group, Membrane Biology Research Group, Budapest, Hungary Debasish Roy (M.Sc., 2011) Vellore Institute of Technology, Vellore, Tamil Nadu, India Balázs Takács (Ph.D., 2011) Westermann group, Research Institute of Molecular Pathology, Vienna, Austria Judit Gervai (M.Sc., 2012) Szüts Group, Institute of Enzymology, Hungarian Academy of Sciences Kata Sarlós (Ph.D., 2012) Hickson group, University of Copenhagen, Denmark Máté Gyimesi (postdoc, 2007-2012) Kowalczykowski group, University of California, Davis, USA page 4 of 15 Curriculum vitae Mihály Kovács Committee memberships Fellows Advisory Committee (NIH, 2003-2005) Board of Supervisors (Hungarian Biochemical Society, 2011-) Scientific Committee for Biochemistry, Molecular Biology, Genetics and Cell Biology (MTA, 2011-) Vice Chair, Student Scientific Research Council in Biology (ELTE, 2012-) Society memberships Hungarian Biochemical Society (2000-) European Society for Muscle Research (2001-) American Society for Cell Biology (2003-) BPS (2003-) Public Body of MTA (2006-) Other community activities Public science writing (see Articles and interviews in Hungarian, 2002-) Organization of departmental research seminars (ELTE, 2006-) Invitation of guest lecturers (ELTE, 2006-): 11 occasions Public and media appearances (National Talent Development Council, Hungarian Innovation Association, Society of Hungarian Young Scientists, OTKA, see also Media appearances, 2009-) Society Research Achievement Awards Poster Judge (BPS, 2011) Journal article reviews Journal of Biological Chemistry (2003-) Journal of Biochemical and Biophysical Methods (2005-) Medical Science Monitor (2005-) Cell Biology International (2006-) Biophysical Journal (2007-) FEBS Journal (2009-) EMBO Journal (2009-) International Journal of Molecular Sciences (2010-) Cellular and Molecular Life Sciences (2011-) Interface Focus (2011-) Grant review and board membership OTKA (2009-) MTA (2011-) National Excellence Program (2012-) Degree review and board membership M.Sc. thesis review (ELTE, 2006-): 6 occasions Ph.D. thesis review (ELTE, BME, PTE, 2006-): 6 occasions Ph.D. final exam board membership (ELTE, SE, 2006-): 9 occasions Ph.D.
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