Compound Name Matrix Methodology Acetaminophen Human Plasma LC-MS/MS Acetylsalicylic acid and Salicylic acid Human Plasma LC-MS/MS ACTH (1-39) Human Serum LC-MS/MS Adiponectin Human Plasma ELISA AAG Human Plasma ELISA Albumin Human Plasma ELISA Aldosterone Human Plasma LC-MS/MS aldosterone, corticosterone, 11-deoxycorticosterone & 18- Human Plasma LC-MS/MS hydroxycorticosterone Amikacin Human Plasma LC-MS/MS Amino acids (19) Human Plasma LC-MS/MS Amphotericin B Human Plasma LC-MS/MS Amphotericin B Human Urine LC-MS/MS Amyloid Beta 1-40 Human CSF ELISA Amyloid Beta 1-42 Human CSF ELISA Androstenedione, Dehydroepiandrosterone (DHEA), and Human Serum LC-MS/MS Testosterone Androsterone and etiocholanolone Human Urine LC-MS/MS Angiotensin I (for Plasma Renin Activity) Human Plasma LC-MS/MS Arachidonic acid Human Plasma LC-MS/MS Atorvastatin, 2-Hydroxy Atorvastatin, 4- Hydroxy Human Plasma LC-MS/MS Atorvastatin, and Atorvastatin Lactone

Atorvastatin, Atorvastatin lactone, 2- Hydroxy Atorvastatin Dog Plasma LC-MS/MS Lactone & 4-Hydroxy Atorvastatin Lactone Exenatide Rat plasma LC-MS/MS Exenatide Mouse Plasma LC-MS/MS Bile acids (15) Human Serum LC-MS/MS Bortezomib Human Plasma LC-MS/MS

Medpace Bioanalytical Laboratories Page 1 of 10 5365 Medpace Way, Cincinnati, OH 45227 Phone: (513) 579-9911, Fax: (513) 579-0444

Compound Name Matrix Methodology Budesonide Human Plasma LC-MS/MS Bupivacaine Human Plasma LC-MS/MS Busulfan Human Plasma LC-MS/MS Cathepsin-S Human Plasma ELISA C Reactive Protein (CRP) Human Plasma ELISA Caffeine and Paraxanthine Human Plasma LC-MS/MS Calcitonin Rat Plasma LC-MS/MS

Capecitabine, 5’ Deoxy-5-fluorocytidine (5’- DFCR), 5’- Human Plasma LC-MS/MS Deoxy-5-fluorouridine (5’-DFUR), and 5-Fluorouracil (5-FU)

Anti-CAM-H2 Human Serum ECL Carboplatin Human Plasma LC-MS/MS Carboplatin Human Plasma Ultrafiltrate LC-MS/MS Dog Plasma Human Plasma Rat Plasma Carboplatin (as Platinum) ICP-MS Dog Plasma Ultrafiltrate Human Plasma Ultrafiltrate Rat Plasma Ultrafiltrate C-Peptide Human Plasma ELISA CD24 Human Serum ELISA Anti-CD24 Human Serum ECL

Human Plasma Cetirizine LC-MS/MS Human Urine

Chemerin Human Plasma ELISA Calprotectin Human Stool ELISA Cholesterol Human Plasma LC-MS/MS 7-keto cholesterol and cholestane-triol Human Serum LC-MS/MS

Medpace Bioanalytical Laboratories Page 2 of 10 5365 Medpace Way, Cincinnati, OH 45227 Phone: (513) 579-9911, Fax: (513) 579-0444

Compound Name Matrix Methodology

Cholic Acid, Deoxycholic Acid, and Chenodeoxycholic Acid Human Serum LC-MS/MS

Dog Plasma Human Plasma Rat Plasma Cisplatin (as Platinum) ICP-MS Dog Plasma Ultrafiltrate Human Plasma Ultrafiltrate Rat Plasma Ultrafiltrate Clarithromycin Human Plasma LC-MS/MS Clobetasol 17-propionate Human Plasma LC-MS/MS Clonazepam Human Plasma LC-MS/MS Clonidine Human Plasma LC-MS/MS (s)-Clopidogrel Human Plasma LC-MS/MS Clopidogrel, carboxylic acid and active metabolite Human Plasma LC-MS/MS Human Plasma Cortisol LC-MS/MS Human Urine Cortisol and 11-Deoxycortisol Human Plasma LC-MS/MS Cortisol, aldosterone and tetrahydroaldosterone Human Urine LC-MS/MS Cotinine Human Serum LC-MS/MS C-Peptide Human Plasma ELISA Creatinine Human Serum LC-MS/MS CXCL2 Human Plasma ELISA

Anti-CXCL2 Human Plasma ECL CXCL5 Human Stool ELISA

Human Plasma HP-β-Cyclodextrin LC-MS/MS Human CSF Cyclophosphamide (CP) and 4- Hydroxycyclophosphamide Human Plasma LC-MS/MS (4OHCP)

Medpace Bioanalytical Laboratories Page 3 of 10 5365 Medpace Way, Cincinnati, OH 45227 Phone: (513) 579-9911, Fax: (513) 579-0444

Compound Name Matrix Methodology Cyclophosphamide Human Plasma LC-MS/MS 24S-hydroxycholesterol Human Serum LC-MS/MS Dehydroepiandrosterone (DHEA) , 17α- Human Serum LC-MS/MS hydroxypregnenolone and 17α-hydroxyprogesterone Dehydroepiandrosterone Sulfate Human Serum LC-MS/MS Dexamethasone Human Plasma LC-MS/MS Dexmethylphenidate Human Plasma LC-MS/MS Diclofenac Human Plasma LC-MS/MS Diethyldihydroxyspermine Human Plasma LC-MS/MS N1-N14-diethyl-3,12-dihydroxyhomospermine Human Plasma LC-MS/MS Human Plasma Digoxin LC-MS/MS Human Urine Docetaxel Human Plasma LC-MS/MS Docetaxel Human Plasma Ultrafiltrate LC-MS/MS Docosapentaenoic acid (DPA) Human Plasma LC-MS/MS Domperidone Human Plasma LC-MS/MS Donepezil Human Plasma LC-MS/MS Dopamine, Epinephrine, Norepinephrine Human Plasma LC-MS/MS Doxorubicin & Doxorubicinol Human Plasma LC-MS/MS Duloxetine Human Plasma LC-MS/MS Eicosapentaenoic Acid (EPA) and Docosahexenoic Acid Human Plasma LC-MS/MS (DHA)

Eicosapentaenoic Acid (EPA), Docosahexaenoic Acid (DHA) Human Blood Cell LC-MS/MS and Arachidonic Acid (AA) Enzalutamide Human Serum LC-MS/MS Eotaxin Human Plasma ELISA Ergosterol, Sitostanol, Brassicasterol, Stigmasterol, Human Plasma LC-MS/MS Campesterol and β-Sitosterol

Medpace Bioanalytical Laboratories Page 4 of 10 5365 Medpace Way, Cincinnati, OH 45227 Phone: (513) 579-9911, Fax: (513) 579-0444

Compound Name Matrix Methodology β-Estradiol Human Plasma LC-MS/MS Esketamine and norketamine Human Plasma LC-MS/MS Estrone Human Serum LC-MS/MS Human Blood Ethanol GC-MS Human Plasma Ethinyl estradiol (EE2), norethindrone (NE) Human Plasma LC-MS/MS Etoposide Human Plasma LC-MS/MS Exenatide Rat Plasma LC-MS/MS Human Plasma Famotidine LC-MS/MS Human Urine n-3 and n-6 fatty acids Human Red Blood Cell LC-MS/MS Fe and Cu (total) Human Plasma ICP-MS Human Plasma Fentanyl LC-MS/MS Human Urine Fosfomycin Rat Plasma LC-MS/MS Free Quercetin Human Plasma LC-MS/MS Fluconazole Human Plasma LC-MS/MS Furosemide Human Plasma LC-MS/MS Furosemide Human Urine LC-MS/MS Gemcabene, furosemide, metformin and rosuvastatin Human Plasma LC-MS/MS Gemcabene Human Plasma LC-MS/MS

Gemcitabine Human Plasma LC-MS/MS Gemfibrozil Mouse Plasma LC-MS/MS

Gentamicin LC-MS/MS GFAP Human CSF ELISA Glargine/M1/M2 Insulin Dog Plasma LC-MS/MS Glucagon Human Plasma LC-MS/MS Grapiprant Human Plasma LC-MS/MS

Medpace Bioanalytical Laboratories Page 5 of 10 5365 Medpace Way, Cincinnati, OH 45227 Phone: (513) 579-9911, Fax: (513) 579-0444

Compound Name Matrix Methodology Glutathione (GSH)-GSSG Human Blood LC-MS/MS Glycohemoglobin Human Blood LC-MS/MS Histamine Human Serum LC-MS/MS α-Hydroxybutyrate Human Plasma LC-MS/MS β-Hydroxybutyrate Human Plasma LC-MS/MS Human Plasma 7α-Hydroxy-4-cholesten-3-one (7αC4) LC-MS/MS Human Serum 24S-Hydroxycholesterol Human Plasma LC-MS/MS Trans-4-Hydroxy-L-Proline Human Urine LC-MS/MS 25-Hydroxy-Vitamin D3 and 1α,25-Dihydroxy-Vitamin D3 Human Plasma LC-MS/MS IGF-1 Human Plasma ELISA Human Plasma IGFBP-1 ELISA Human Serum Iloprost Human Plasma LC-MS/MS IL-18 Human Plasma ELISA Human Plasma IL-8 ELISA Human Serum IL-17 Human Stool ELISA IL-23 Human Stool ELISA Insulin Human Plasma ELISA Interleukin-1beta (IL-1β) Human Plasma ELISA

Interleukin-1RA (IL-1RA) Human Plasma ELISA Interleukin-6 (IL-6) Human Plasma ELISA

Irinotecan and SN-38 Human Plasma LC-MS/MS Itraconazole Human Plasma LC-MS/MS Ketamine Human Plasma LC-MS/MS Human Plasma Ketoconazole, Digoxin, Midazolam, Rifampin LC-MS/MS Human Urine

Medpace Bioanalytical Laboratories Page 6 of 10 5365 Medpace Way, Cincinnati, OH 45227 Phone: (513) 579-9911, Fax: (513) 579-0444

Compound Name Matrix Methodology Ketoconazole Human Plasma LC-MS/MS KIM-1 Human Plasma ELISA Lapatinib Human Plasma LC-MS/MS Lactoferrin Human Stool ELISA Letrozole Human Plasma LC-MS/MS L-Leucine Human Plasma LC-MS/MS Leukotriene B4 Human Plasma LC-MS/MS Leuprolide Dog Plasma LC-MS/MS Leptin Human Plasma ELISA Linezolid Human Plasma LC-MS/MS Lathosterol, lanosterol and desmosterol Human Serum LC-MS/MS Lysosphingomyelin Human Plasma LC-MS/MS Malondialdehyde (Free and total) Human Plasma LC-MS/MS MCP-1 Human Plasma ELISA MCP-1/CCR2 binding Human Whole Blood Flow Cytometry Human Plasma Melatonin LC-MS/MS Human Urine Melphalan (Free and total) Human Plasma LC-MS/MS Mesalazine and N-Acetyl Mesalazine Human Plasma LC-MS/MS Human Plasma Metformin LC-MS/MS Human Urine

Methamphetamine and Amphetamine Human Plasma LC-MS/MS Methotrexate and 7-Hydroxy Methotrexate Human Plasma LC-MS/MS d/l-threo-Methylphenidate Human Plasma LC-MS/MS Metoprolol Human Plasma LC-MS/MS Midazolam and 1’-Hydroxy Midazolam Human Plasma LC-MS/MS Momentasone Furoate Rabbit Plasma LC-MS/MS

Medpace Bioanalytical Laboratories Page 7 of 10 5365 Medpace Way, Cincinnati, OH 45227 Phone: (513) 579-9911, Fax: (513) 579-0444

Compound Name Matrix Methodology Moxifloxacin Human Plasma LC-MS/MS Moxifloxacin and Levofloxacin Human Plasma LC-MS/MS Mycophenolic Acid (MPA), Glucuronide-MPA (MPAG) Human Plasma LC-MS/MS Nalmefene Human Plasma LC-MS/MS Naloxone Human Plasma LC-MS/MS NGAL Human Plasma ELISA Nilotinib Human plasma LC-MS/MS Nilotinib Human CSF LC-MS/MS Omeprazole and 5-Hydroxyomeprazole Human Plasma LC-MS/MS Paclitaxel Human Plasma LC-MS/MS Pentoxifylline and Lisofylline Human Plasma LC-MS/MS Papain PBS Buffer ELISA Perhexiline, cis-hydroxy perhexiline & trans-hydroxy Rabbit Plasma LC-MS/MS perhexiline Phenylalanine and tyrosine Human Plasma LC-MS/MS Phloroglucinol Human Plasma LC-MS/MS Pioglitazone, Hydroxylpioglitazone (M-II), Human Plasma LC-MS/MS Hydroxypioglitazone (M-IV) and Ketopioglitazone (M-III) Plasminogen Activator Inhibitor-1 (PAI-1) Human Plasma ELISA Prednisone Human Plasma LC-MS/MS Proinsulin Human Plasma ELISA

Quinidine and Verapamil Human Plasma LC-MS/MS RANTE/CCR5 binding Human Whole Blood Flow Cytometry

RBP4 Human Plasma ELISA Rifampicin Human Plasma LC-MS/MS Ritonavir Human Plasma LC-MS/MS Human Plasma Ropinirole and N-Despropylropinirole LC-MS/MS Human Urine

Medpace Bioanalytical Laboratories Page 8 of 10 5365 Medpace Way, Cincinnati, OH 45227 Phone: (513) 579-9911, Fax: (513) 579-0444

Compound Name Matrix Methodology Rosuvastatin and Desmethyl Rosuvastatin Human Plasma LC-MS/MS Sacrosidase PBS ELISA sE-Selectin Human Plasma ELISA Sildenafil Human Plasma LC-MS/MS Simvastatin & Simvastatin hydroxy acid Human Plasma LC-MS/MS Solifenacin Human Plasma LC-MS/MS Spironolactone Human Plasma LC-MS/MS Squalene Human Plasma LC-MS/MS Sulbactam Human Plasma LC-MS/MS Sunitinib and N,N-Didesethyl Sunitinib Human Plasma LC-MS/MS Suvorexant Human Plasma LC-MS/MS Tacrolimus (FK-506) Human Blood LC-MS/MS TARC Human Plasma ELISA Tau Human CSF ELISA pTau Human CSF ELISA Human Plasma Testosterone and Androstanolone Human Serum LC-MS/MS Human Serum Ultrafiltrate Anti-TNFRII-Fc Human Plasma ECL Toremifene Human Plasma LC-MS/MS Total Quercetin Human Plasma LC-MS/MS

Transforming Growth Factor Beta1 (TGF -β1) Human Plasma ELISA Trans-vitamin K1 and cis-vitamin K1 Human Serum LC-MS/MS

Human Plasma Tumor Necrosis Factor-alpha (TNF-α) ELISA Human Stool Human Plasma Urea LC-MS/MS Human Epithelial Fluid Vancomycin Human Plasma LC-MS/MS

Medpace Bioanalytical Laboratories Page 9 of 10 5365 Medpace Way, Cincinnati, OH 45227 Phone: (513) 579-9911, Fax: (513) 579-0444

Compound Name Matrix Methodology VEGF Human Serum ELISA Vincristine Human Plasma LC-MS/MS Dog Plasma Vitamin K1 LC-MS/MS Rat Plasma Vitamin K1 and Vitamin K2 Human Plasma LC-MS/MS Rat Blood Voclosporin LC-MS/MS Rabbit Blood Warfarin Human Plasma LC-MS/MS R-Warfarin & S-Warfarin Human Plasma LC-MS/MS Zolpidem Human Plasma LC-MS/MS (s)-zopiclone Human Plasma LC-MS/MS Zopiclone Human Plasma LC-MS/MS

Medpace Bioanalytical Laboratories EARPage-000 107 -of0420 10 5365 Medpace Way, Cincinnati, OH 45227 Phone: (513) 579-9911, Fax: (513) 579-0444