Photonics West• Show Daily

WEDNESDAY EDITION

WEDNESDAY, FEBRUARY 11, 2015 PHOTONICS WEST • Lihong Super-resolution Wang microscopy interview with Eric Betzig SHOW DAILY p. 21 p. 9

DON’T MISS Not just for gimmicks. THESE EVENTS 3D printing meets optics on the TODAY show floor with products from Multiphoton Optics, Femtoprint, and Luxexcel. LASE PLENARY SESSION Credit: Trish Tunney. 10:20 AM-12:30 PM, ROOM 134 • Tribute to Charles Townes • Best paper awards • Donald Cornwell Jr., NASA • Jens Limpert, Friedrich-Schiller University • Xiaoyan Zeng, Wuhan National Lab for Optoelectronics

INDUSTRY EVENTS SPIE Job Fair (10 AM-5 PM) Optics and photonics salaries panel (8-9:30 AM, Room 101) Conflict minerals panel (8-10 AM, Room 134) Inbound marketing workshop (10:30 AM-12 PM, Room 101) Executive perspectives panel (1:30-2:30 PM, Room 134) Getting hired panel (1:30-2:30 PM, TODAY’S NEWS Room 101) Hiring talent (3-4:30 PM, Room 101) SPIE Startup Challenge (3:30-6 PM, Room 134) 3 See the technical program and exhibition guide D printing: the next industrial revolution? for more details on daily events. Conference registration may be required. Industry events are It’s being hailed as the next industrial revo- In fact, the widespread adoption of 3D cess of adding material in layers to create a open to all registration categories. lution, and it’s taken the public’s imagination printing could upend currently accept- solid part from a 3D CAD model, has been a by storm. But 3D printing — also known as ed manufacturing economics by allowing work in progress since the technology first additive manufacturing, rapid prototyping, products and components to be produced emerged in the 1980s. In recent years, ad- IN THIS ISSUE laser deposition, and selective laser melting economically in smaller numbers, with more vances in hardware, software, lasers, and 7 International Year of Light — isn’t just for gee-whiz demos of instantly flexibility and using new materials. photonics have yielded additive manufac- launch “printed” toys, car parts, or tchotchkes at But where does the hype end and com- turing equipment that can produce met- 9 Nobel interview: Eric Betzig industrial and consumer tradeshows. mercial implementation begin? That was the al and plastic components at speeds and 13 Into the Valley: the rise of It’s an emerging production process on focus of a panel session on 3D printing at quantities necessary to support a viable Wuhan the verge of truly revolutionizing industrial Photonics West Tuesday. business model. 21 Interview: Lihong Wang manufacturing — and opening up new busi- With its roots in laser sintering and laser In fact, the 3D printing market is about 34 Biophotonics funding panel ness opportunities for lasers and photonics. welding, additive manufacturing, the pro- continued on page 03

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3D Printing continued from page 01 other alloys, and it took about 10 years rect metal laser melting” — to streamline community becomes more comfortable to hit the big time, according to John to get the fundamentals in place, such as the production of very complex parts for in using these tools, and as manufactur- Dexheimer, president of Lightwave Ad- 100 percent density, tensile strengths, and aerospace products, according to Todd ers become more integrated into the ac- visors, a financial consulting firm that fatigue behavior. Rockstroh, a consulting engineer at GE tual future of what you can do in terms works closely with the technology sector. Poprawe noted that productivity posed Aviation. of performance, it will drive innovation Companies like Stratasys and 3D Systems an additional challenge. In particular, GE has redesigned a fuel throughout the entire process.” have been around since the industry’s “Between 2005 and 2010, we increased nozzle that previously comprised 20 sep- As with any emerging market, chal- early days, “but only in the last couple the buildup speed by a factor of 10, which arate parts made from multiple materials lenges remain, including the need to of years have they ‘busted into a single part utilizing develop standards to ensure product out,’” Dexheimer said. one alloy and 19 soldering quality and consistency and a clearer A recent report from The Applications of 3D Printing operations that can be pro- understanding of the impact additive McKinsey Global Research symposium at Photonics West duced via laser melting in manufacturing will have on the tradi- projects that the 3D print- a matter of days. tional machine-tool sector. ing market could be worth highlights papers from BiOS, LASE “We’d been toying Some equipment providers, such as $550 billion a year by 2025 and OPTO on innovative ways to around with additive DMG Mori, are already developing hybrid — a trend that bodes well manufacturing on this systems that combine a machine tool, ma- for the laser and photonics apply 3D printing technologies. nozzle and took 20 parts, chining center, and direct laser sintering industry. put them into an assem- in a single system. Technology is enabling the applica- I think made the key change in attention bly model, built it, did some testing, and But in the long run, the opportunities tions in additive manufacturing, and “la- on metal additive manufacturing,” he said. found that the 3D printed part works as for growth make this an exciting time to sers are the engine that makes it work,” “We were able to increase the buildup well as the machined part and is 20 per- be in additive manufacturing. In addition Dexheimer said. “What needs to be done base so significantly that additive manu- cent lighter,” Rockstroh said. to growing interest in multihead, multi- to increase throughput, handle multiple facturing became macroscopically inter- Rockstroh, who was scheduled to be wavelength lasers that can deposit and metals, enable simultaneous processing esting for production environments, and on the 3D printing panel Tuesday but was process different materials simultaneous- and in-line metrology inspection — all of we have systematically lowered the cost unable to attend at the last minute, told ly, other opportunities for photonics in this is laser driven. The whole underlying for lightweight components. Less weight the Show Daily in a recent interview that this market include infrared imaging for infrastructure is lasers and photonics.” at less cost, regardless of the complexity.” the 3D printed part was less expensive to nondestructive testing and inspection and manufacture and is expected to reduce fuel systems integration software. Productivity challenge Faster, cheaper, lighter consumption. Using 3D printing also took KATHY KINCADE The Fraunhofer Institute has been at the The aerospace industry has also been a 10-12 hours out of the build cycle, he said. forefront of developing additive manufac- driving force in the development and com- “What GE is doing with these nozzles turing with metals for 20 years. Reinhart mercialization of additive manufacturing is really just at the cusp of what additive Poprawe of Fraunhofer ILT said Fraun- for metals. GE Aviation, for example, has manufacturing can do,” said panelist Jim hofer’s additive manufacturing research spent nearly a decade developing 3D man- Williams, vice president of Aerospace and Scan to follow Photonics initially focused on stainless steel and ufacturing techniques –what they call “di- Defense at 3D Systems. “As the design West news online.

3D printing for lab equipment The growing interest of researchers in the use of 3D printing for healthcare applications ranging from cus- tomizable laboratory microscopes to bio-printed organs was evident during the Sunday evening poster Making connections: business being done on the show session at BiOS. floor. Meanwhile, Lattice Materials is now offering silicon with diameters greater than 445mm. Credit: (l) Trish Tunney, A poster that drew a lot of at- (r) Doug Cody tention highlighted recent work undertaken by Craig Brideau and others on a team at University of Calgary using 3D printing tech- Optically actuated micro-robotics nologies in laboratory settings for David Phillips of University of Glasgow of the same tip from two different angles. with a resolution below 10 nm. basic health-science research. received the best paper award in the In combination with 2D tracking and Phillips demonstrated successful ex- They presented an overview of Advanced Fabrication Technologies for the use of three handles (optical traps), re- periments in which a microscopic object existing 3D printing technologies Micro/Nano Optics and Photonics confer- searchers are able to achieve six degrees of is visible as well as the tip. While the tip like polymer jet printing, fused ence earlier this week at Photonics West freedom to measure what objects are doing. is pushing softly against the object, the tip deposition modelling, selective for a new kind of scanning probe micros- Because they can fabricate any desired is moved within the XY plane, tracing the laser sintering, and stereolithog- copy (atomic force microscopy) based on shape and size of tip using two-photon surface of the object, which is monitored raphy and demonstrated how these optical tweezers. polymerization of a photoresist materi- by the optical tweezers. techniques could be used to cus- The technology uses a 2D nanoscale al, researchers can work with 50-nm tips For applications in micro-robotics, tomize existing lab equipment such tip, fabricated by direct laser writing and and even manipulate the restoring force of Phillips proposes a crank-like mechanism as adapters for combining devices, trapped using three focused laser beams the optical traps. Designed with a slightly that can pick up an object and rotate it in guides, microscopy, sample prepa- through holographic methods, allowing con- conical tip, Phillips said the new probes the microscope, and control flow, as the ration, MRI, etc. trol or read of both the position and torque were able to create a constant force pla- direction of the flow can now be changed of the tip. Additionally, they record the view teau in the restoring force, probing objects in a flow chamber.

Photonics West: The world’s largest marketplace for photonics, optics, imaging, and industrial lasers 04 | WEDNESDAY, FEBRUARY 11, 2015

Kinetic River demos off-the-shelf flow cytometer Flow cytometry specialists at the Califor- pared with a normal build time of around Excelitas. Vacca says that 99 percent of the He adds that the flow cytometry mar- nian biophotonics company Kinetic River 18 months. parts that feature in the flow cytometer ket, worth an estimated $6 billion when have built a versatile new system entire- Key to that rapid development was have been sourced from the combined the hematology sector is included, is ly from commercial off-the-shelf (COTS) the late-2013 acquisition of Qioptiq by company. He says that the difficulty in evolving fast. The pure cytometry part parts — in less than two developing such a system is growing at a compound annual rate months. previously was the sheer of around 10 percent. Some users are Company president and length of time that it would looking for new developments like bet- founder Giacomo Vacca, take to get off the ground ter sensitivity to smaller particles, which who is highlighting the — not to mention the costs is needed for clinical studies using na- dual-laser setup at the involved. no-scale biomarkers, while others need Excelitas booth this week, “The ability to have more channels and greater multiplexing. said that the kit went from a working instrument The demonstration prototype on view concept to demonstration in less than two months at Photonics West features two fiber-cou- in just eight weeks, com- is mind-boggling,” said pled Qioptiq lasers, plus an internally Vacca, who hosted a short sourced optical system featuring Linos Kinetic River’s versatile course on trends in flow Photonics components, a fluidic control flow cytometer, built inside cytometry at Photonics subsystem, and Excelitas fluorescence two months using all off- the-shelf parts. Credit: Trish West on Monday. “It usual- detectors. Tunney. ly takes a year and a half.” Excelitas Technologies is at booth 1723. Smart phone kit detects Giardia bug Vivolight The new BiOS conference strand Op- from contaminated water, food, or by the a dedicated algorithm) within one hour. expects tics and Biophotonics in Low Resource fecal-oral route. This rapid analysis contrasts favorably Settings kicked off with Hatice Ceylan Although primarily a problem facing with conventional high-tech procedures, Chinese Koydemir, a postdoctoral researcher in the developing world, and arising as a which Koydemir said can often take a few OCT boom Aydogan Ozcan’s UCLA research group, consequence of sewage-contaminated days — not particularly helpful if a remote presenting a new smart phone-based an- drinking water and poor hygiene, the dis- village needed to take preventative mea- Shenzhen-based optical coherence to- alyzer that can rapidly identify the prob- ease can also be a problem in developed sures to deal with a contaminated source mography (OCT) specialist Vivolight lematic water-borne bacterium Giardia countries. of drinking water. says that it expects the market for the Lambli. The Ozcan group is well-known for its She concluded, “Our water-borne imaging technology in China to boom One of the most common water-borne work on these types of analyzers. Here, the pathogen detection system is a promising in the coming years. pathogens worldwide, Giardia Lambli is, sampling technology incorporates smart tool for the detection of Giardia Lamblia OCT system engineer Qingyun Li according to the World Health Organi- phone, LED illuminator, sample hold- cysts in resource-limited settings due to from the company told Show Daily that zation, responsible for an estimated 280 er and battery pack, but measures only its advantages over traditional methods. the Chinese government was supporting million nasty cases of illness every year. 205 mm x 77mm and weighs just 205g. Besides its low cost, easy portability and domestic technology developers. “China Symptoms include diarrhea, weight loss Koydemir explained that it will analyze a rapid turnaround time, there is no need wants to build its own medical equip- and other debilitating ailments of the 20ml sample, transmit the resulting image for opto-mechanical parts or conventional ment industry,” he said, adding that he digestive tract. Infection occurs when and then receive the result from a central benchtop equipment to analyze a sample.” expected the emerging market for OCT dormant microbial cysts are swallowed server (which processes the image with MATTHEW PEACH systems there to become “huge.” Vivolight’s endoscopic system will be aimed at applications in esophageal and cardiovascular imaging, once clinical certification in China has been ap- Oil prospects depend on photonics proved. But Li believes that, technolog- Despite the recent shock in prices, the Jones. “I think that oil is currently some- through at any time,” Jones told the ically speaking, Vivolight’s approach oil industry remains a great opportunity where below its long-term stable price. seminar. “We also need to have reservoir is already capable of competing with for developers of rugged photonics-based And a lot of people in the industry expect production monitoring down-hole, so that similar systems from more established testing and monitoring systems. So says that it will increase again soon. In 15 years we can see any changes in chemistry in suppliers but with a lower price tag. Christopher Jones, an R&D manager at time I won’t be surprised if it’s greater real time.” The company has also developed Halliburton Technology. Jones addressed than $160 per barrel.” He added that there was now a huge a completely different optical system the Lasers and Photonics Marketplace Following a detailed explanation of the emphasis on fracking in certain markets. that can be used to locate veins accu- Seminar held Monday this week. economics of oil and gas extraction, Jones “We need to be able to assess the water rately, to aid with injections. Its “Pro- Jones manages Halliburton’s fluid iden- listed numerous opportunities for pho- supply because this process uses a lot of jection Vein Finder” is based on the tification, pressure testing and sampling tonics-based systems, including hydraulic water. Recycling that water is desirable, absorption of near-infrared light by technology group and oversees an optics fracturing (fracking). Such devices need [and] optical monitoring of the flow-back hemoglobin. team, a reservoir fluids interpretation to be able to cope with extremely harsh water [could] solve a lot of problems.” Vivolight, set up by researchers team, and a chemometrics team. One of conditions, including temperatures up to With an estimated two million miles of from the Xi’an Institute of Optics the company’s own photonics-based tools 450°F, a wide range of acidic and alkaline oil and gas pipelines worldwide, installa- at the Chinese Academy of Sciences is called “ICE” (Integrated Computation- solutions, pressures of 30,000psi, and ex- tion monitoring offers systems developers and Tsinghua University, claims to al Elements). It enables down-hole fluid treme vibration. a great opportunity. “What we really need be China’s first high-technology en- analysis and delivers “lab-quality results.” “The biggest opportunities in oil and to be able to do is take an optical chemis- terprise to specialize in biophotonics “Despite the recent drop, the oil price gas include pipeline hydrocarbon content try laboratory to the field and then down imaging systems. Among its investors looks like it may be stabilizing again at assessment and measurement, because the hole,” he said. are SAGE-Angel Venture Capital and about the $50 per barrel mark,” said we really have to know what’s flowing MATTHEW PEACH Shaanxi Xike Angel Venture.

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reaction of photosynthesis, which con- since Egyptian Ibn Al-Haytham wrote his Nobel winners light up Paris verts carbon dioxide and water into sugar Book of Optics, which included chapters and oxygen, and so the essentials for us on early research into color, visual per- to live. Identifying this photonics-related ception, reflection and refraction. for International Year launch reaction led to an earlier Nobel prize in Zewail concluded by calling for the ap- Laureates Steven Chu, Ahmed Zewail, Zhores Alferov, chemistry for Melvin Calvin in 1961.” plication of greater investment and train- Like several other presenters at the ing to alleviate people in need around the William Phillips and Serge Haroche make for a star- event in Paris, which took place less than world suffering from poverty, a lack of ed- studded launch event at the UNESCO headquarters. two weeks after the Charlie Hebdo atrocity, ucation and political exploitation. “Glob- Zewail acknowledged and deplored the at- ally, we need to see investment, leadership More than a thousand delegates con- consortium of scientific bodies together tack. He then stressed to the audience that and, above all, vision,” he said. verged on UNESCO’s headquarters in with UNESCO, intended to bring together all civilizations and religions throughout Steven Chu, who won the 1997 physics Paris, France, for the two-day launch cer- scientific societies and unions and educa- Nobel for work on laser cooling of atoms emony of the International Year of Light tional institutions. before serving as US Secretary of Energy (IYL) in January, joining a roll-call of dip- “The UN has recognized the impor- for four years until 2013, gave the second lomats, Nobel laureates, and photonics tance of raising global awareness about plenary talk, entitled “Energy and Climate industry decision-makers. how light-based technologies promote Change: Challenges and Opportunities.” Opening the year-long event, United sustainable development and provide He highlighted the importance of pho- Nations Secretary-General Ban Ki-moon solutions to global challenges in energy, tonics and diverse optical techniques for said via video message that the role light- education, agriculture and health. An In- measuring key indicators such as ocean based technologies play in accelerating ternational Year of Light is a tremendous temperatures, atmospheric gas concen- sustainable development will help the opportunity to ensure that international trations and glacier thickness. international community meet the chal- policymakers and stakeholders are made Chu acknowledged the work of James lenges of the 21st century. aware of the problem-solving potential of Clerk Maxwell, who almost exactly 150 He told the 1000-strong audience: “As light technology.” years ago brought together the ideas of we strive to end poverty and promote Among the high-profile scientists to The Nobel-winning spectroscopist Ahmed electricity, magnetism, and light as man- shared prosperity, light technologies offer speak at the launch were Nobel laureates Zewail, a plenary speaker at the recent ifestations of the same phenomenon. practical solutions to global challenges. Ahmed Zewail, Steven Chu, Zhores Al- launch event for the International Year of “Nowadays, we are working with electro- Light held in Paris. Credit: Matthew Peach. They are particularly important in ad- ferov, William Phillips and Serge Haro- magnetic radiation across more than 24 vancing progress towards achieving the che, covering light and life, energy, tele- history have tried to discover the origins orders of magnitude,” he said. future global sustainable development communications, and the fundamental and importance of light, invariably making “At the one extreme, 100Hz is rather goals and addressing climate change.” physics of light-matter interactions. it a key part of their cultures. slow for data transmission although it still The UN chief’s “Sustainable Energy for Zewail, the Linus Pauling Chair pro- “Many of the ancient civilizations, exceeds the amount of useful information All” initiative is intended to boost access to fessor of chemistry and physics at the whether Chinese, Buddhist, Hindu, Jew- that the average politician can speak,” energy, energy efficiency and the use of re- California Institute of Technology, said ish, Muslim or Christian, have from early Chu joked. He reminded the audience newables by 2030, a move that he believes in his “Light and Life” plenary: “From the days worked to gain understanding of our that ocean temperature data have showed will translate to “a safer, healthier and Big Bang to the current state of the world, relationship with light. Early Egyptians a general increase from the earliest re- more productive future” and bring more roughly 14 billion years on, we recognize Akhenaten and Nefertiti were some of the corded figures in 1860 through today’s light to homes, hospitals and enterprises. that light plays a key part not only in all first worshippers of the sun, who recog- satellite-gathered data. “Fourteen of the John Dudley, chairman of the IYL 2015 our lives today, but it has done so through- nized the importance of our fundamental fifteen hottest temperatures that we have Steering Committee, told delegates: “The out the entire period of the evolution of power source.” ever recorded have occurred in the 21st International Year of Light is an oppor- earth and all of its life. Next to the main conference hall in the century — and we have only had fourteen tunity to inspire, educate, and connect ”Sunlight provides us with food, at- UNESCO building was a substantial new years of records in the 21st century.” on a global scale. It is the initiative of a mosphere and energy through the key display commemorating the 1000 years MATTHEW PEACH

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Super-resolution microscopy: only structured light meets the challenges of biology Eric Betzig’s contributions to super-resolution microscopy were recognized by the Nobel committee in 2014, when he was among the laureates of the 2014 Nobel chemistry laureate Eric Betzig spoke alongside co- chemistry prize. His current research on light-sheet winners Stefan Hell and William Moerner at a special Sunday evening BiOS plenary session microscopy has given him clear opinions on the dedicated to their achievements in super-resolution microscopy. directions in which super-resolution technology should Credit: Eric Betzig, Janelia Research Campus, Howard now be headed. Hughes Medical Institute.

Super-resolution microscopy, incorporating various in- out to have another even more fundamental advantage: genious methods of outsmarting the laws of optics just much lower phototoxicity — the damage to specimens sufficiently to image features smaller than the theoretical from the light used to view them. diffraction limit of a microscope, hit the headlines last Oc- “Spreading the energy out has a huge effect in reduc- tober courtesy of the Royal Swedish Academy of Sciences. ing photobleaching and phototoxicity,” noted Betzig. “In One of the three pioneering researchers who shared fact, you get almost the best of all worlds: nearly isotropic the Nobel Prize in Chemistry that month was Eric Betzig, 3D resolution at high speeds, but without damaging based at the Jane- the cell. In certain cases where the relevant protein is “At Janelia I’m lia Research Cam- particularly highly expressed, you can essentially image pus of the Howard it indefinitely.” surrounded by Hughes Medical biologists all the Institute, Mary- Peak power: a key issue land. A regular at Inadvertent damage to the fragile living cells and tissues time, and that’s SPIE Photonics under examination has become a key issue in high-res- essential.” West, Betzig was olution microscopy. Work on lattice-sheet microscopy recognized for his has convinced Betzig that the peak power delivered to ERIC BETZIG. work on the sin- a specimen may be an even more important metric of gle-molecule mi- cell health than the total photon dose it receives. This croscopy technique he first demonstrated in 2006, but in turn means that not all super-resolution microscopy he has since remained heavily invested in the search techniques are created equal. for new and effective microscopy techniques suitable Confocal processes in particular are inherently dis- for biological systems. In particular, that has led to the advantageous in terms of their impact on cells, and tech- development of so-called structured illumination mi- niques such as stimulated emission depletion (STED) croscopy (SIM). microscopy — another breakthrough recognized by the The latest fruits of this research appeared shortly continued on page 11 after the Nobel announcement: a paper in Science by Betzig’s research group described a new microscope employing ul- trathin light sheets derived from two-di- mensional optical lattices, which were scanned through a specimen to generate a 3D image. “The lattice light-sheet microscopy technique evolved from our work on the use of Bessel beams — non-diffractive light beams which do not spread out while they propagate,” said Betzig. “Bes- sel beams help increase the resolution of fluorescence microscopy, but they have problematic side-lobes in the beam profile. Stepping the beam instead of sweep- ing it helps counteract that problem, and led us to the use of a structured array of beams created using a diffractive optical element. Each beam then only has to step over a fraction of the field of view.” The lattice approach was not only Betzig’s CGI chromosomes: intracellular dynamics in three dimensions, built up from individual non-invasive lattice light-sheet microscopy images inherently faster and yielded improved during cell mitosis. Credit: Eric Betzig, Janelia Research Campus, Howard signal to noise performance, but turned Hughes Medical Institute. People Products Innovation who understand your application. that set the standard of excellence. that drives your industry.

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Microscopy continued from page 09 working on will fill that gap.” Nobel committee last year — need to find ways to control For that to happen successfully, Betzig’s techniques the peak power they deliver. need to leave the laboratory and become available to Photo-activated localization microscopy (PALM), an- users. Janelia’s Advanced Imaging Center (AIC) was other super-resolution technique of which Betzig was created to make the campus’s imaging technologies ac- an early developer, exposes cells to much lower levels of cessible to scientists before the instruments are com- energy, but requires in turn a high density of fluorescent mercially available. labels to produce meaningful images. Betzig commented “Technology transfer is a topic near and dear to my that the problem of high labelling density can easily turn heart,” he commented. “The nice thing about PALM is super-resolution studies into stories of sample prepara- that it’s so simple: essentially a microscope, a camera, tion, rather than hardware and a little software that’s development. “Of all the super-resolution now available in many These trade-offs be- open source versions. The tween phototoxicity, spa- methods, the only one tech transfer with PALM tial resolution, temporal happened organically be- resolution, and imaging with a real prayer of finding cause almost anyone can depth have increasing- a significant application do it — although sample ly become the norm in preparation remains vital, [ picture this ] high-resolution microsco- space in live-cell imaging and not everyone does that py, and Betzig believes that is structured illumination part well.” while some approaches Lattice light-sheet mi- You can safeguard critical infrastructure are technically ingenious, microscopy.” croscopy is less straight- with all-in-one perimeter security and they are inherently unable forward, and the technol- to meet some practical re- ERIC BETZIG. ogy transfer operation will equipment monitoring. quirements. need a helping hand. The “As I see it, the fundamental reasons for doing flu- AIC is intended as the lowest rung of that process, giving orescence microscopy in the first place are to achieve researchers hands-on experience. The next level is avail- protein-specific contrast and structural imaging, and do ability of the platform’s design and associated documen- so in live cells,” he commented. “Of all the super-resolu- tation; some 30 groups have executed research licenses tion methods, the only one with a real prayer of finding a on that basis, and Betzig knows of four microscopes significant application space in live-cell imaging is SIM. currently running. For outright commercialization, the Any kind of confocal or point-scanning super-resolution platform is licensed to Zeiss, with a sub-license to 3i in operation is just not compatible.” the US. The fruits of that agreement will come to market over the next couple of years. Transferring out of the lab “The technique is starting to trickle out to biologists At Janelia, successful structured illumination of live cells by those routes — and that’s critical,” commented Betzig. is one of Betzig’s research priorities, and in particular “I view all these microscopy innovations as being clever finding ways to extend the technique to resolutions below combinations of lasers, computers, labeling technology the 100 nm mark. and detectors; the four different pieces of the puzzle “From 100 nm to 200 nm, I think you would be an id- which all came on the scene in the 1980s. But at present, iot to do anything other than SIM; it’s easy, fast, non-de- most of the work is not informed by contact with biol- Design products for preventative structive, and needs no specialized labels. And below 50 ogists. At Janelia I’m surrounded by biologists all the maintenance and diagnostics with nm, localization microscopy is the clear winner, able to time, and that’s essential to guide the direction of your provide structural imaging and count individual mole- work and know what the real challenges are. I don’t think custom development tools that cules. So the only area where the jury is currently out is that happens enough. It’s great for this technology to get simplify the end-user experience. the 50 to 100 nm regime, particularly in the live context. the Nobel Prize, but I think we still have a lot to prove.” Extended-resolution SIM methods like the ones we are TIM HAYES

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The movements of protozoa can be captured in individual images, although the rapid morphological changes represent a challenge. Credit: Eric Betzig, Janelia Research Campus, Howard Hughes Medical Institute.

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Into the Valley: Wuhan’s rise to global prominence Established nearly 15 years ago, Wuhan’s Optics Valley has matured into a powerful and joined-up base for academic research, business incubation and industrial photonics.

In recent years, the Wuhan Optics Valley has emerged optoelectronic devices and integration; optoelectronic as one of the world’s key centers for the research, de- detection and radiation; and photonics for energy. velopment and production of laser and optics technol- Another key institution is the Wuhan Industrial Insti- ogy — something reflected in the region’s ever-growing tute for Optoelectronics (WIIO), described by authorities presence at Photonics West. Also known as the Wuhan as a “collaborative innovation platform.” It provides the East Lake High-tech Development Zone (WEHDZ) and more applied aspects of engineering technology research the Wuhan East Lake National independent Innovation and development, as well as offering the investment and Demonstration area, the region is to be found in eastern business incubation necessary to promote the industri- [ picture this ] China, just south of the city of Wuhan itself. alization and commercialization of WNLO’s research Established back in 1988, the WEHDZ was the first and development work. national high-tech Industrial Development Zone (IDZ) “WIIO is an incubation platform, which is under- You can empower customers to set up by China’s State Council. In 2001, the Wuhan pinned by WNLO and the Wuhan government with fund- evade costly environmental and Optics Valley of China was also approved as a state-level ing, office space provision and favorable policies,” says optoelectronic industry base. hazardous fire threats. “After twenty years of endeavor and development, WEHDZ has formed a comprehensive industry structure covering optoelectronics, bioengineering, energy 1/3 AD and environmental protection, modern agriculture and hi-tech service industry,” says Professor Qingming Luo, Vice Pres- ident of Huazhong University of Science and Technology (HUST) and Executive Deputy Director at the Wuhan National Laboratory for Optoelectronics (WNLO). “It is the biggest manufacturing and research and development base of optical products, optoelectronic communication technology and laser industry in China, taking a firm place in the global industry,” he told Show Daily. China’s presence at the Photonics West exhibition has grown solidly in Build systems that deliver dependable recent years, and the emergence of the Wuhan region as a key center Image Contrast Enhancement (ICE™) National laboratory for both research and industry is part of the reason for that. Credit: Joey Cobbs/SPIE. and focused ICE-o-Therms™ for better Luo also says that Wuhan is one of the country’s key scientific and educational bases, ranking spokesperson Yang Xu. “Most of the incubated projects situational awareness. third among the major Chinese cities in terms of scien- are initiated by the research teams in HUST university tific and educational capabilities. The region is home and WNLO, and the platform positions its interests in to no fewer than 78 universities, among them Wuhan common technology research and development, indus- University and HUST. On top of that there are 106 science trial pilot trials, and high-end incubation. and research institutes of various kinds, 20 national “One of the purposes of WIIO is to integrate start-up laboratories, seven state-level key laboratories and en- businesses with local industrial resources in order to pro- gineering research centers, and 15 national enterprise mote economic growth along the whole value chain of op- technology centers. toelectronics,” he adds, echoing the ethos and language In the field of photonics technology development, the of innovation now being advocated seemingly throughout most important of these knowledge centers is the Wuhan the western world. “By leveraging the connections with National Laboratory for Optoelectronics (WNLO), one academics, industrialists and venture capitalists, WIIO of the initial five national laboratories approved by the endeavors to support start-ups and transform their in- Ministry of Science and Technology (MoST) in 2003. lab ideas into industrial innovation and new products.” Co-founded by the Ministry of Education (MoE), Hubei Xu says that the support work carried out at WIIO Provincial Government and Wuhan Municipal Govern- ranges across all areas of optoelectronics, choosing to ment and supported by HUST — a national key university highlight projects focused on the development and com- of China — WNLO is now the chief innovation base of mercialization of OLED materials, UV-LED components, Wuhan Optics Valley of China (WOVC) and something laser applications, digital storage solutions, biomedical of a research powerhouse, hosting more than 120 re- devices and what he calls a “big data engine.” searchers and 1000 graduate students. “Since we don’t do the technological research our- Booth #5110 They carry out research across six focused areas of selves, it is the incubated project teams who have [the] application: biomedical photonics; information stor- expertise to drive their business. We provide the services, age and optical display; laser and terahertz technology; continued on page 15

201502PhotonicsWest_ShowDaily_RevA.indd 2 1/20/2015 10:03:03 AM SOLUTIONS WITH LIGHT DEFORMABLE METAL SOLDERED MIRROR MIRRORS LENS

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Fraunhofer Institute for Applied Optics and Precision Engineering IOF Learn more at www.iof.fraunhofer.de See us at Booth 4601-34

Optical Metrology Brighter Solutions from www.deltaopticalthinﬁlm.com for Dynamic Environments Unrivaled Linear Variable Filters

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BiOS Expo Booth 8322 Photonics West Booth 322

Brighter Solutions from ® See the New AccuFiz Short Coherence Interferometer Delta Optical Thin Film A/S at Photonics West, South Hall, Booth 700. www.deltaopticalthinfilm.com WEDNESDAY, FEBRUARY 11, 2015 | 15

Wuhan Optics Valley continued from page 13 “new ideas, new technologies and new methods for solv- funding (if applicable) and, through WNLO, the support ing medical and biological problems by using photonics they need to succeed.” principles and technologies.” One of the chief aims here is to improve understanding of neuronal information WNLO research themes processing mechanisms, and to carry out research that One of the six key themes of the work carried out at could lead to early diagnosis and treatment of life-chang- the WNLO is focused on the field of Op- ing chronic conditions like toelectronic Devices and Integration. It cancer and Alzheimer’s, as involves research aimed at improving well as the more acute im- the acquisition, transmission, exchange pact of debilitating events and calculation functions of informa- such as strokes. tion-based optoelectronics devices More specifically, re- through the development of new mecha- search projects in the nisms, structures and processes. area of neurophotonics Key breakthroughs here include inte- include high-resolution grated optoelectronic devices for high- optical imaging of cra- speed coherent optical communication nial nerve junctions and networks and high-performance comput- super-resolution imaging Get the full picture. ing (HPC), including optical interconnects. of neural circuit connec- Other devices developed to date include tions. Other biophoton- Complete your OEM design an AlGaN-based ultraviolet detector, in- ics laboratory techniques + tegrated optoelectronic devices used for under evaluation include project with accurate microwave and terahertz photonics and high-resolution blood flow temperature measurement and new types of nanophotonics devices. Reception area at the Wuhan Industrial laser speckle imaging ap- A second theme is Laser and Tera- Institute for Optoelectronics, a plications and new molec- absolute clarity. Hertz Technology, involving research collaborative platform built by China’s ular imaging and molecu- government and universities and with $80 into the physical phenomena of lasers million initial funding. Credit: WNLO. lar tomography techniques and the development of new lasers with designed to meet some of high power, high beam quality, high stability and long the shortcomings of existing scanners. lifetimes. Other key aspects of the work carried out “Micro-Optical Sectioning Tomography (MOST) under this theme include research into the interaction technology fills the gap between magnetic resonance mechanisms between lasers and biological tissues and imaging and electron microscopy imaging, and is used the development of terahertz wave applications in sev- to study the fine structure of biological tissue, especially eral fields — including the detection of explosives and in brain research,” says Xu. “It provides a powerful tool contraband. Other uses include the analysis of material to establish 3D imaging for bio-mapping [at the scale defects, moisture detection, medical diagnostics, trace of] centimeters.” gas detection and biomedical imaging. Another theme of the work at the laboratory relates WNLO scientists operating in this area have de- to “information storage and optical display,” where staff veloped high-performance optical fibers based on ra- carry out comprehensive research into a range of areas related to information storage technology, including data storage principles, devices and equipment and storage systems and applications. Some of the key breakthroughs so far include active object-based mass storage systems and technology, and high-speed and low-power consumption phase change memory technology. Looking ahead, future work carried out under this theme will include the de- Introducing Tamarisk® Precision Series velopment and commercialisation of ser- radiometric camera cores from Wuhan Yangtze Soton Laser (YSL Photonics) was set up by University vice-oriented large-scale storage systems, of Southampton alumnus Kang Kang Chen. It is exhibiting at this year’s DRS Technologies. For OEMs that Photonics West. Credit: YSL Photonics. as well as new glass-based optical memory devices and solid state disk “memristors.” demand the full picture. re-earth doping — useful for the high-power fiber laser technology that is an increasingly common sight with- Flexible solar cells in China’s manufacturing base. Wuhan’s researchers In an effort to resolve some of the common problems have also conducted in-depth theoretical and practical and limitations of conventional solar cells — like low See for yourself at booth #5110. research into laser stereolithography (LSL) and micro conversion efficiencies and poor stability — theEnergy fabrication technology in laser processing. Photonics Division at WNLO also conducts research With an eye on future semiconductor industry re- on semiconductor materials, across the fields of ener- quirements, other efforts are focused on the development gy production, storage, transmission, conservation and of a laser-generated plasma source of extreme ultraviolet utilization. That includes new optoelectronic devices, for (EUV) light. example basic research into flexible thin-film solar cells, light-emitting displays and transistor arrays. Biomedical applications One recent breakthrough was the lab’s development Among the more obvious application-led themes, WNLO’s of a fully printable mesoscopic perovskite solar cell that Biomedical Photonics Division stated aim is to provide continued on page 16 drsinfrared.com | 855.230.2372

201502PhotonicsWest_ShowDaily_RevA.indd 3 1/20/2015 10:03:07 AM Fiber Optics 16 | WEDNESDAY, FEBRUARY 11, 2015 polarization maintaining for wavelengths 370 – 1700 nm

Laser Beam Coupler 60SMS-1-4-… Wuhan Optics Valley continued from page 15 forms crystals with a longer exciton lifetime. That and Inclined fiber coupling does not use a hole-transporting layer. Crucially, it boast- better pore filling of the mesoporous oxide film than the axis ed a 12.84% conversion efficiency and more than 1000 single-cation perovskite are thought to have improved

Apochromatic fiber hours stability under full sunlight in ambient tempera- photovoltaic performance “dramatically.” optics 400 - 660 nm R G ture — sufficiently impressive to earn the work a publi- According to the research group, which is led by Pro- B cation in the journal Science. fessor Hongwei Han at WNLO in collaboration with the Fiber with Endcaps 405 460 532 660 Reduced power density V Prior to that, similar cells have featured a hole-trans- renowned Professor Michael Grätzel from EPFL in Swit- at fiber end-face 405 460 532 633 ( factor 100 ) Fiber Common collimator portation layer and electrodes based on noble metals, zerland, the innovation is something of a breakthrough Fiber Amagnetic (Titanium) NEW Fiber Connectors and 60FC-... which help to promote the efficient movement of electri- — suggesting that low-cost, high-efficiency mesoscopic Fiber Optic Components Endcap cal current after exposure to solar energy. However, the solar cells based on cheap, clay-like perovskites could materials required are expensive, while devices based find widespread applications. At the time, Professor Han Fiber Optics, on them tend to lack long-term stability. said: “It is only the beginning of a new era of fully print- Components and Tools To overcome this challenge, the research team con- able PV and certainly new efficiency records will follow for Fundamental Research structed a ‘scaffold’ made up of a double layer of mes- this first report.” oporous titanium dioxide and zirco- ANDREW WILLIAMS LOW Fiber Coupled Laser Sources YSL Photonics has just NOISE 51nanoFI-... / 51nanoFCM-... nium dioxide, infiltrated by a mixed launched a new higher- LOW cation lead halide perovskite used as power supercontinuum COHERENCE with singlemode and source with an output and polarization-main- a light harvester. Instead of using a REDUCED of up to 10 Watts, and SPECKLE taining fiber cables hole conductor or gold reflector — of a picosecond 1064nm

Fabry Perot Applications: Laser Deflection the sort typically employed in high fiber laser featuring Interferometry Measurement efficiency perovskite solar cells — the burst-mode function. Atomic 51nanoFI-... Credit: YSL orce Power back contact is made up of a simple F icro- Control Photonics. Mscopy Faraday printed carbon layer. Nanotube Isolator The perovskite is drop-cast from Measurement System a solution through this porous car- Polarization Analyzer Series SK010PA-... bon layer and the research team has Interface: USB 2.0 · Multiple Wavelength Ranges 350 – 1600nm verified that perovskite formed in the A Fiber collimator 60FC-Q-... presence of the two organic cations B Adapter for fiber connector

Adjustment of quarter-wave plates Adjustment 45° of right- and left-handed Industrial impact: the Southampton connection cir cular polarization. Measurement of Polarization Extinction Ratio The wider Wuhan Optics Valley percontinuum lasers and a 1 for industrial customers, includ- Connector key A area is home to several well- micron wavelength source for ing a picosecond supercontin- Core Polarization known companies. Initially, that industrial applications. uum source for the bio-indus- Good Alignment Bad B meant optical communications The supercontinuum fo- try [that] has been used for SAN FRANCISCO, CALIFORNIA primarily — including the likes cus is a big clue to the back- applications like super-reso- FEBRUARY 10 - 12, 2015 of FiberHome Technologies ground of Kang Kang Chen, lution imaging, fluorescence Visit us in North Hall, Booth 4936 Group, Wuhan Telecommu- CEO at YSL Photonics, who spectroscopy and microscopy, nications Devices, Accelink, founded the company after flow-cytometry and optical co- Laser Line, Micro Focus, Chutian Laser Group, Yangtze studying high-power pulsed herence tomography.” Laser Pattern Generators Optical Fibre and Cable Com- fiber lasers at the University Looking ahead, Chen ex- Wavelengths 405 – 2050 nm pany, Yangtze Optical Elec- of Southampton’s Optoelec- plains that YSL’s long-term

Application tronic Co. and of course the tronics Research Center (ORC) plan is to extend its laser wave- 3D Profiling and Process Control multinational telecoms giant in the UK. “I believe that our length to cover applications Huawei Technologies. Less well semiconductor seeded fiber from the UV to the mid-in- known perhaps, but appearing MOPA has a very high poten- frared, to extend the tunable at this week’s exhibition, are a tial in the commercial laser pulse-width range from fem- number of innovative start-up market due to its superb re- toseconds to a few nanosec- companies, the likes of Wuhan liability and versatile contin- onds, and to increase the rep- Lasers and Line Scan Cameras for Huaray Precision Laser and uously tunable pulse width,” etition rate of the source into Research and Machine Vision Wuhan Raycus Fiber Laser he told Show Daily. “[It] can the gigahertz regime. Technologies, both of which fill the gap between a tradi- He concludes: “And of have established operations in tional mode-locking laser and course higher powers! These Line Scan CamerasSK 9170: Gray Scale Line Signal – 0 Color, monochrome, or255 sensors the region more recently. a Q-switching laser.” features will make our prod- from 512 to 8160 pixels

0 ZOOM 0 SK 9170: Gray Scale Line Signal – 1 One interesting relative According to Chen, the high ucts more flexible but require 255 Interfaces: ZOOM newcomer is Wuhan Yangtze power output delivered by the us to develop better seed NEW USB 3.0 0 0 TM Soton Laser (YSL Photonics), MOPA can be used directly in lasers, better amplifiers and an optics company focused a variety of industrial applica- better wavelength conversion on the development and man- tions and, when launched into techniques.” ufacture of ultrafast picosec- a photonic crystal fiber (PCF), Visit Wuhan’s spin-outs: YSL ond and sub-nanosecond the supercontinuum source. Photonics is at booth #2723; color monochrome

1.0 100 1.0 fiber laser technology for bi- “At the moment, the systems Huaray Precision Laser at Spectral

J/cm2) rangerange

(V/m ophotonic and micromachin- look decent and we have de-

Responsitivity booth #2017; Raycus Fiber 0.0

400Relative sensitvity 600 800 1000 0 0.0 Wavelength (nm) 400 500 600 700 800 400 500 600 Wavelength (nm) Wavelength (nm) ing applications. The compa- livered nearly 100 units to our Laser Technologies is at booth ny currently has two product customers,” said the CEO. “We #5412. The WIIO institute is at lines, namely a series of su- [have now] launched two series booth #5417. [email protected] www.SuKHamburg.de

Made in Germany Photonics West: The world’s largest marketplace for photonics, optics, imaging, and industrial lasers

AZSPIE-PhotonWestShowDaily_02-2015.indd 1 14.01.2015 17:11:04 optics.org product focus SPIE Photonics West 2015 Edition

Photonics West is the premier photonics and laser event. With more than 1,250 companies, this exhibition continues to be the flagship event to find the latest products, tools, and applications for your research or business needs.

The Moscone Center San Francisco, California, United States product focus 10 - 12 February 2015

Welcome to the optics.org Product Focus which we have published specifically for All this information and more can be found on the optics.org website. Photonics West 2015 in partnership with SPIE and the Photonics West Show Daily. Simply go to www.optics.org for all the latest product and application news. Here you will find an effective at-a-glance guide to some of the latest products available Alternatively, why not sign up to our free weekly newsletter on the market with booth numbers if available making it easy for you to check out the (www.optics.org/newsletter) and get the information delivered direct. products for yourself.

MultiCentric® Cementing Station Multiplies the Efﬁ ciency of the Cementing Process

• Lens alignment and cementing process with unrivaled productivity • Short cycle time less than 10 sec • SmartAlign Technology for the best lens centration: the upper lens is aligned to the optical axis of the lower lens • Alignment accuracy better than 2 µm

See us in Hall B Booth #1833 www.trioptics.com

Tri_Anzeige_Product-Focus_248x222_DU-1601_RZ.indd 1 20.01.15 16:37 optics.org: Contact Rob Fisher, Advertising Sales tel: +44 (0)117 905 5330 fax: +44 (0)117 905 5331 email: [email protected] follow us on twitter @opticsorg optics.org product focus SPIE Photonics West 2015 Edition

ALTECHNA Visit us at Booth #5135 Diamond SA Visit us at Booth #4235

PowerXP F-SMA PSi Fiber Optic Power Connector The PowerXP is a compact version of Altechna’s Diamond has further developed its existing F-SMA motorized attenuator. This device attenuates free space (SMA 905) MM connectors specifically for medium-high laser beam (or pulse) continuously without introducing power laser delivery and thermal management in various additional energy fluctuations. Contrast better than applications. 3000:1 (Tp:Ts) is achieved, since this attenuator is This class of connectors is employed typically for beam mounted with high contrast polarizer. This very injection of medium-high power Diode Lasers (DL) in order compact attenuator version can be easily integrated in to provide a fiber-optic link between the DL source and the custom optical systems. target. Product features: Contact Details High power transmission is achieved by the copper alloy Contact Details Divides laser beam into two parallel beams of UAB ALTECHNA ferrule and the excellent fiber alignment. Laser safety can be Diamond SA • adjustable intensity ratio Mokslininku st. 6A ensured by using steel-armored protection tubes. Via dei Patrizi 5, CH-6616 Losone, 08412 Vilnius, Lithuania Switzerland High optical damage threshold Diamond’s enhanced F-SMA PSi connector is based on the • www.altechna.com Cu-ferrule free-standing fiber technology with outstanding www.diamond-fo.com Low dispersion for femtosecond and high energy [email protected] [email protected] • laser pulses mechanical tolerances and eccentricity. And uses the mode Tel: +1 408 372 1513 strip technology to remove the undesired cladding modes. Tel: +41 91 785 45 45 • Stand-alone USB powered controller

greenTEG AG Visit us at Booth #4328 Voltage Multipliers Inc. Visit us at Booth #5128

Laser Power Heads Visit Voltage Multipliers Inc. greenTEG’s Laser Power Heads enable fast and easy to find out more about the measurements of average laser powers up to 50 Watts 50kV OC500 optocoupler with a non-accelerated response time of less than 250 The OC500 is designed for a push/pull milliseconds. configuration. The active module is a thermal detector and therefore The optocoupler has two legs, each capable of sensitive to the whole spectrum from UV to MIR. 25kV switching voltage. Each leg can be controlled Three models with nominal maximum laser powers of independently via low voltage LED connections. 5W, 10W and 50W are available. The OC500 features a standoff voltage capability of 50kV between the low voltage LEDs and the high Other laser power ranges are available upon request. Contact Details Contact Details greenTEG AG voltage diode, a DC gain of 0.28% minimum (0.40% Karen Spano Mounting threads and channels for optional water Technoparkstr. 1 typical), and compact packaging. Voltage Multipliers, Inc. cooling are incorporated into each head. 8005 Zurich VMI manufactures high voltage diodes, 8711 W. Roosevelt Ave., Switzerland optocouplers, power supplies, and components. Visalia, CA, USA 93291 www.greenTEG.com ISO9001:2008 registered. [email protected] [email protected] www.voltagemultipliers.com Tel: +41 44 632 04 20 www.highvoltagepowersupplies.com Tel: +1 (559) 651 1402

Varioptic Visit us at Booth #5519 Nanoscribe GmbH Visit us at Booth #4232

Liquid Lenses and Auto Focus 3D Printer for the Micrometer Scale M12/C-Mount modules Nanoscribe´s Photonic Professional GT systems provide Varioptic’s electrowetting technology enables ultra- maskless lithography and additive manufacturing on fast and robust Auto Focus from a few centimeters (or the micrometer scale in one device. closer) to infinity, with absolutely no moving parts. The 3D printers, winners of 2014 Prism Award, are The product range includes liquid lens components unique with respect to resolution and writing speed: as well as M12 and C-mount imaging lens modules, Empowered by their unprecedented 3D nano-/ with a choice of focal lengths and sensor size micro-fabrication capabilities, the two-photon compatibility – addressing various applications in polymerization driven systems set new standards machine vision, barcode reading, medical imaging, Contact Details in various applications, e.g. in photonics, MEMS, Contact Details lasers… Varioptic - a BU of Parrot SA micro-optics, and small series production. Besides Nanoscribe GmbH serving the scientific market, Nanoscribe also provides The new, revolutionary Visayan 80S0 liquid lens will 24B rue Jean Baldassini Hermann-von-Helmholtz-Platz 1 69007 Lyon and develops solutions for pioneering innovators in D-76344 Eggenstein-Leopoldshafen be available in 2015 – its 8-electrode design offers France industry. Germany variable astigmatism in addition to variable focus, for innovative ophthalmology equipment design. www.varioptic.com Visit us at Photonics West 2015: booth #4232 www.nanoscribe.de [email protected] (North Hall) [email protected] Tel: +33 (0) 4 37 65 35 31 Tel: +49 721 60 82 88 40

Iridian Spectral Technologies Visit us at Booth #515 Special Optics, A Navitar Company Visit us at Booth #601

Leader in Optical Filter Solutions High quality laser optics and IRIDIAN provides optical thin film filter solutions and custom high NA microscope coating services to a wide variety of industrial and objectives research sectors. Special Optics, A Navitar Company, offers a range The company is a leading global supplier for of high quality laser optics and custom high NA applications in telecommunications, spectroscopy microscope objectives. (Raman, fluorescence, flow cytometry), biomedical imaging and sensing, and entertainment (glasses for Achromatic, apochromatic, single line and UV 3D cinema, display coatings). focusing objectives; VIS-NIR, confocal, telecentric UV laser scanning lenses; and a family of high Contact Details Contact Details Our optical filters and coatings cover the spectrum transmission, diffraction limited laser beam from prototype development to volume production Iridian Spectral Technologies expanders. Special Optics, Inc offering the highest levels of performance and 2700 Swansea Crescent 315 Richard Mine Road durability at competitive prices. Ottawa, ON, Canada Custom objectives available for working distances Wharton, New Jersey 07885 K1G6R8 from 0.3 mm to 30 mm; tailored to function at New products: MWIR filters, Multi-spectral arrays, www.specialoptics.com www.iridian.ca wavelengths from visible light (390-750 nm) to [email protected] LaseReflect glasses. the near infrared (700-1400 nm); and modified for [email protected] Tel: +1 973 366 7289 Tel: +1 (613) 741 4513 aqueous, oil, and vacuum research environments.

optics.org: Contact Rob Fisher, Advertising Sales tel: +44 (0)117 905 5330 fax: +44 (0)117 905 5331 email: [email protected] follow us on twitter @opticsorg optics.org product focus SPIE Photonics West 2015 Edition

Diverse Optics Inc. Visit us at Booth #217 CMOSIS Visit us at Booth #109

Custom Precision Polymer Optics CSI2000 When you’re looking for precision polymer optics to reduce CMOSIS introduces the CSI2000, featuring a 1440 x 1440 cost, trim weight, simplify design, and improve performance, pixel array with 12 x 12 um2 black and white global come to Diverse Optics. shutter pixels. We specialize in diamond turning (SPDT) and precision A frame rate of over 700 fps at 10 bits/pixel is output injection molding of custom polymer optics. over 36 LVDS channels supporting row windowing and Prototype to series production of spheres, aspheres, domes, X/Y mirroring. With its full well capacity of min. 1.6 Me-/ convex/concave, plano/convex, bi-convex, free-forms, pixel is the CSI2000 optimized for FFOCT and other diffractives, Fresnels, prisms, light-pipes, cylinders, lens arrays, medical/scientific imaging applications. collimators, combiners, toroids, CPC’s, TIR’s, micro-optics, Contact Details This enables the detection of small signal variations in Contact Details mirrors, parabolics, off-axis, ellipticals, cylinders, and more! Ms. Letty Trevino, Sales Engineer bright images captured at high-speed. CMOSIS Whether it’s diamond turned prototypes or thousands of Diverse Optics Inc., 10310 Regis Court, This development received funding from the EU FP7- Coveliersstraat 15 Antwerp, Belgium molded optics, we’ll show you how polymer optics are Rancho Cucamonga, CA 91730 ICT-2011-8 (agreement 318729). perfected. www.diverseoptics.com www.cmosis.com [email protected] [email protected] Tel: +1 (909) 593-9330 Tel: +32 3 260 17 30 Fax: +1 (909) 596-1452

Ibsen Photonics Visit us at Booth #943 Xenics Infrared Solutions Visit us at Booth #834

FREEDOM mini Raman Versatile SWIR T2SL camera We introduce the FREEDOM mini Raman up to 2.35 μm spectrometer which offers the perfect balance Hyperspectral imaging or laser beam analysis with extended between compact size and high performance in SWIR is of special interest. The new Xeva- your instrument design. 2.35 SWIR camera operates from 1.0 to 2.35 μm with a 4-stage Due to the small size, robust performance, and TE Cooler at 350Hz full frame. high resolution this unit is ideal for integration into Spectrometer compatible portable instruments for Raman Spectroscopy. • Scientific image recording and analysis The spectrometer is very flexible and can be used • with many different laser wavelengths and detector Contact Details • Smallest TE4 - cooled camera for low dark current Contact Details systems. Ibsen Photonics • Two gain modes for high sensitivity or high dynamic range Xenics nv For instance, with a 785 nm laser 200 – 3650 cm-1 Ryttermarken 15-21, DK-3520 Farum Ambachtenlaan 44 Denmark High speed imaging at 100 Hz (USB2.0) or 350 Hz BE-3001 Leuven, Belgium can be covered with a resolution of 10 cm-1. • (CameraLink) www.ibsenphotonics.com www.xenics.com [email protected] Read the full product specifications: [email protected] Tel: +45 44 34 70 00 www.xenics.com/SWIR-T2SL-camera-oo Tel: +32 16 38 99 00 Fax: +45 44 34 70 01 Live demo booth# 834 Fax: +32 16 38 99 01

CILAS Visit us at Booth #1223 ALPhANOV Visit us at Booth #1323

The largest coating platform Triggered picosecond laser using magnetron sputtering platform technology in Europe ALPhANOV introduces a new triggered picosecond CILAS has the largest coating platform using laser platform based on a fully fibered innovative magnetron sputtering technology in Europe, design. which can deposit optical coatings on pieces up This platform enabled the development of to 2 m x 2 m (6.5 ft by 6.5 ft), up to 40 cm thick and compact, robust and therefore reliable lasers (1064, weighing up to 1.5 tons (3000 lbs). 532 or 355 nm), at a very affordable cost. The platform has a five position load-lock for an The combination of high average power (above 50 Contact Details Contact Details increased productivity which enables a very large W), high repetition rate (up to 2 MHz) and pulse number of components to be processed in a CILAS energy of up to 50 μJ leads to a family of sources Ludovic LESCIEUX single run with an exceptional uniformity. 8 avenue Buffon, BP6319 dedicated to numerous applications including: ALPhANOV 45063 Orléans Cedex 2 - France Rue François Mitterrand, industrial machining for photovoltaic applications, Coatings: dielectric, aluminium and silver mirrors, 33400 Talence, France www.cilas.com selective ablation, cutting glass or LEDs; nonlinear metal-dielectric light absorbers, anti-uv filters, [email protected] www.alphanov.com dichroics, anti-reflexion. optics. Tel: +33 (0)2 38 64 15 55 [email protected] Tel: +33 524 545 200

MÖLLER-WEDEL OPTICAL GmbH Visit us at Booth #436 Navitar Visit us at Booth #601

Advanced Goniometer MicroMate 3:1 Zoom Lens System of GONIOMAT series The MicroMate was designed to work with today’s high MÖLLER-WEDEL OPTICAL’s advanced semi and fully resolution 4/3” sensor cameras. It images onto a 22.5mm automatic GONIOMATs are the first choice for ultra- diagonal with no vignetting when combined with Navitar precision measurement of prisms, polygons, wedges objectives. and angle gauges. The MicroMate also allows you to capture and process Due to special enhancements to the illumination four times as much critical data at the camera sensor while hardware and the control software the goniometers maintaining pixel resolution. can be used for measurement of micro-prisms with The modular design allows for seamless integration of surface sizes down to 0.5 mm². Contact Details traditional microscope options, such as fluorescence, DIC, Contact Details Of course all of the GONIOMAT’s features, such as MOELLER-WEDEL OPTICAL GmbH brightfield and darkfield imaging. Navitar, Inc measurement of deflection angles and sophisticated Rosengarten 10, 22880 Wedel, Germany Visit our booth #601 for more information. 200 Commerce Drive, Rochester, New York 14623 USA computer-based ray tracing analysis of the www.moeller-wedel-optical.com measurement data for verification, can also be used [email protected] www.navitar.com for micro-prism measurements. United States Customers: [email protected] Vermont Photonics Technologies Corp. Tel: +1 (585) 359-4000 www.vermontphotonics.com Toll-free: 800-828-6778

ID Quantique SA Visit us at Booth #1040 SEEKING OXYGEN? The power for O Detection – Superconducting nanowire with 2 50% quantum efficiency and eagleyards DFB-760 and fastest electronics DFB-764 Laser Diodes hit ID Quantique’s ID280 series detection system the lines consists of a superconducting nanowire detector combined with high performance electronics. With quantum efficiencies higher than 50%, count rates of up to 20 MHz, dark counts <50 Hz (at 2.3K), jitter below 70ps and no afterpulsing, this system Contact Details outperforms all commercial single photon detectors in all parameters. ID Quantique SA, Ch, de la Marbrerie, 3 1227 Carouge/Geneva, Suisse/Switzerland To see our live demo please visit Besides the nanowire and electronics, the ID280 www.idquantique.com comes with everything that is necessary to install it [email protected] us at South Hall, Booth # 743 in your own cryostat; including feed-throughs and Tel: +41 22 301 83 71 cryogenic cables and connectors. www.eagleyard.com

Arden Photonics Ltd Visit us at Booth #5515

BQM-50 Beam Propagation Analyzer DR_11170_eyP_Anzeige_Laser_2015_114_3x76_2mm_001Seitex1von1 1 15.01.15 10:20 The BQM-50 Beam Propagation Analyzer from Arden Photonics. Compact, easy to align and adjust, it measures M² in less than 20 seconds, with a wavelength range of 400 to 1100nm. One of the most compact and capable beam quality systems available, the BQM-50 is designed to allow complete measurement of laser beam propagation the bigger picture characteristics. Contact Details It applies patented NPL technology, which means it Arden Photonics Ltd optics.org product focus has no moving parts. Royston House, 267 Cranmore Boulevard, Shirley, Solihull. B90 4QT. UK a unique print publication specifically This means there is no need for a translation stage www.ardenphotonics.com targeted to major tradeshows and events which is normally required to allow beam widths to [email protected] be sampled as the camera moves through the laser Tel: +44 121 733 7721 caustic. Fax: +44 121 733 7797

PI (Physik Instrumente) LP Visit us at Booth #4801 Next Issues: PI Announces Air Bearing Stage SPIE Defense, Security+Sensing and System Capabilities 20th-24th April 2015 PI (Physik Instrumente) is pleased to announce the introduction of their air bearing stage and system Laser World of Photonics capabilities to complement their comprehensive range of piezo nano positioning stages and hexapod micro 22nd - 25th June 2015 positioning systems. Building upon over 200 man years of in house air To book your space contact Rob Fisher bearing experience including the acquisition in 2014 of Nelson Air Bearing Products in New Hampshire, PI will Contact Details tel: +44 (0)117 905 5330 demonstrate linear, planar XY and Rotary air bearing PI (Physik Instrumente) LP stages at their booth to serve both the research and USA: 16 Albert St, Auburn, MA fax: +44 (0)117 905 5331 www.pi-usa.us industrial markets. email: [email protected] PI is present worldwide with ten subsidiaries, R&D / [email protected] engineering on 3 continents and total staff of 800+. Tel: +1 508 832 3456 Fax: +1 508 832 0506

Spectrum Scientific Inc. Visit us at Booth #2722

UV470-151 spectrometer Spectrum Scientific Inc. introduces the UV470-151 spectrometer, incorporating our aberration corrected concave holographic grating. This single optical element design provides a high throughput and F # 2.0 performance. The addition of a Hamamatsu S11151 CCD detector enhances system performance for light starved applications and boasts a dynamic range of 7200:1 and a signal to noise ratio of 1600:1. The UV470-151 operates in a spectral range from 190-850 nm with a very low stray light of 0.07% @ 340 nm, measured using the ASTM E 387 standard method. The UV470-151 spectrometer Contact Details is offered with interchangeable slit sizes including 15, 25, 50 and Spectrum Scientific Inc. 100 um. This spectrometer will be ideal for OEM customers in 16692 Hale Ave. Irvine, CA 92606 need of a compact UV spectrometer to detect even very low signal levels with good spectral resolution. www.sssioptics.com The UV 470 comes complete with a driver board and SDK, or can [email protected] be purchased as an OEM unit without the driver board. Tel: +1 949 260 9900 Product Page Link http://ssioptics.com/cart/index. php?dispatch=categories.view&category_id=289

optics.org: Contact Rob Fisher, Advertising Sales tel: +44 (0)117 905 5330 fax: +44 (0)117 905 5331 email: [email protected] follow us on twitter @opticsorg WEDNESDAY, FEBRUARY 11, 2015 | 21

Photoacoustic imaging: taking aim at cancer Lihong Wang is this year’s recipient of the Britton Chance Biomedical Optics Award, in recognition of his outstanding contributions to biophotonics. Ultra-Sensitive Cooled Those achievements include the development of photoacoustic imaging, a CCD Cameras for OEM technology which is now making the move from animal to human subjects, Spectral Instruments has a demonstrated and which could dramatically impact early-stage detection of cancer. history with OEM partnership and design of custom cameras tailored to your of unfocused ultrasonic transducers in combination with demanding application. a reconstruction algorithm to generate its images. But in applied photoacoustics, these divisions are Unmatched capabilities fluid. “There is quite a bit of overlap, and several different o ways of defining the field,” explained Wang. “But in each Deep -100 C Cooling case the key advantages lie in the contrast that the tech- Flexible Design nique can deliver, and in its penetration depth. Its use of optical absorption as the contrast mechanism compares Excellent support favorably with fluorescence imaging, which has to rely on the fluorescent quantum yield being adequate. All Cost effective molecules will absorb light to some degree, so in theory PAM could be used to image almost any molecule. That makes it potentially very powerful.” An increased penetration depth arises from the fundamental nature of the photoacoustic effect. Ultrasound scattering in biological tissue happens to be considerably weaker than optical scattering, meaning that a higher spatial resolution is possible and enabling the detection Contact us today to learn how we of an emerging ultrasound signal from several millime- can provide the solution for your ters beneath the surface. “I like to say that we are exploiting photon-phonon OEM camera needs. synergy, and developing a hybrid modality that allows 520-884-8821 or us to achieve both contrast and resolution,” said Wang. [email protected] “The field is certainly expanding very rapidly, and new Lihong Wang’s breakthrough work in the area of concepts are popping up regularly. Proof of that can be Meet us and learn more photoacoustic imaging was recognized with this year’s Britton seen at Photonics West, where the conference on pho- Chance Biomedical Optics Award — officially presented during at Photonics West, the Photonics West BiOS Hot Topics session held on Saturday toacoustic tomography has grown to become one of the evening. Credit: Washington University in St. Louis. largest at the show, now larger than those concerned Booth 3048/3050 with two-photon microscopy or OCT.” The technology behind photoacoustics (PA) and photo- Among those fruitful new concepts are the exploita- acoustic imaging is developing at a rapid pace, driven tion of non-linear effects in photoacoustic imaging; and by its advantages over other optical techniques for cer- the use of specially designed fast-scanning MEMS mir- tain clinical applications — potentially including cancer diagnosis in humans. It exploits the long-established photoacoustic effect, whereby “The [photoacoustics] the absorption of electromagnetic energy causes thermal expansion, which in turn generates a field is certainly transient ultrasonic signal that can be detected and used to build up an image. expanding very rapidly, Although the principle has a venerable history, the current instrumental technique owes and new concepts are much to the efforts of Lihong Wang of Wash- ington University in St. Louis, whose work on popping up regularly. the technology and on other biomedical optics breakthroughs has been recognized by his re- Proof of that can be seen ceipt of the Britton Chance Biomedical Optics Award at the Photonics West BiOS event this at Photonics West.” year. Two major implementations of photoacous- LIHONG WANG. tic technology exist, essentially photoacoustic microscopy (PAM) and tomography (PAT) variants: the rors, able to scan a designated target sample through a former is based on a focused and scanning ultrasonic coupling liquid. A fluid-immersible MEMS mirror can transducer, allowing dark-field confocal photoacoustic allow the scanning operation to be sped up dramatically microscopy to be performed. The latter employs an array continued on page 22 420 North Bonita Avenue | Tucson, Arizona 85745 520.884.8821 | [email protected] | specinst.com 22 | WEDNESDAY, FEBRUARY 11, 2015

Photoacoustics continued from page 21 tissues in vivo,” said Wang. “As a result it fort is the potentially significant clinical cal Instruments of Texas is one developer — although new designs and fabrication can accommodate a lot of innovations and value of the technology. Photoacoustic currently involved in a large-scale study processes for the mirrors are needed in new ideas. The wide range of different size systems have already been commercial- of photoacoustics for breast cancer diag- order to allow them to operate out of their scales detectable, and the fact that there ized by several vendors, primarily for re- nosis — and Wang believes that the full natural atmospheric habitat. are so many different contrast mecha- search using small-animal imaging; but impact of the technology has not yet be- “Photoacoustics may be the only tech- nisms to explore, has allowed work in this the real impact will become apparent as come apparent. nology that allows you to image all the area to grow exponentially.” the technology moves towards human “My dream is that one day we might be way from organelles to cells and tissues, imaging. able to use photoacoustics to screen the and up to organs; a truly multi-scale im- Clinical studies Clinical studies heading in this direc- entire population for early-stage cancer,” aging modality that lets you see cells and One major motivation for this level of ef- tion are already under way — Seno Medi- he commented. “One hallmark of cancer is hypermetabolism — an increased metabolic rate, which affects the rate at which oxygen is consumed. We can use photoacoustic Doppler effects to analyze he- modynamics and compute the metabolic rate of oxygen uptake. We might be able to detect and distinguish between early- and late-stage cancer through assessing some combination of blood oxygen content and A Furukawa Company Your Optical Fiber Solutions Partner® hypermetabolism, and do so without needing to introduce a contrast agent.” That latter simplification alone could remove a substantial complicating factor ™ inherent in large-scale trials, removing TrueMode Fiber Laser Cavities any concerns for side-effects from added agents while also reducing the complexity of the study. for your next Multi-Kilowatt Fiber Laser Other significant applications could include examination of the gastrointestinal

“My dream is that one day we might be able to use photoacoustics to screen the entire population for early- stage cancer.” LIHONG WANG.

tract, where the ability of photoacoustics to detect beneath the surface of the intes- TrueMode-kW tinal lining should give functional information about the structure and hemody- namic behavior of hidden lesions and lead True single-mode output to a very sensitive diagnostic tool. There is also an effort under way to 1kW applications apply the technology to breast imaging. “I’m a strong believer that this is a very Universal pump acceptance promising direction, using non-ionizing radiation to gather functional informa- Low non-linear effects tion in this manner,” noted Wang. “The hope is that we can use it to reduce the Compatible with TrueM2 Beam Combiners terrible rate of false-positives in X-ray mammography.” Tailored lasers Discover your SOLUTION For photoacoustic imaging to realize this potential, some specific hurdles remain to be tackled. Wang recognizes that while preclinical development of the technolo- 10-12 February 2015 Booth #1023 gy is going well, any clinical translation will take time and effort. “If we want to or visit www.ofsoptics.com WEDNESDAY, FEBRUARY 11, 2015 | 23

demonstrate the method’s efficacy for, say, melanoma the penetration depth of the technique. Potentially it imaging, we will need to determine whether to target pa- could boost the penetration depth to reach some tens tient screening, patient diagnosis, or surgical planning,” of centimeters into biological systems — at which point he commented. “Each will require a different approach.” the notion of whole-body imaging of humans starts to Another hurdle relates directly to the components become tantalizingly feasible. used in photoacoustic systems — specifically the bulki- The other major research topic is compressed ultrafast ness and complexity of the laser sources involved. photography (CUP), a technique which has proved capa- “In some respects, ble of capturing the flight standard lasers are prob- of individual photons in ably overkill for us,” Wang “Development of new a laser pulse. “This is the commented. “We do not world’s fastest receive-only need the longest coherence laser sources better 2D camera,” noted Wang, length, or the narrowest tailored for photoacoustic referring to the system’s bandwidth, and for some lack of any specialized ul- YOUR OPTICAL applications we don’t need technology would allow trafast active illumination COATING PARTNER high collimation capabili- in capturing its snapshots. ty either. Development of us to build much more “It records at up to 100 bil- new sources better tailored compact systems, without lion frames per second.” FOR SO MANY for photoacoustic technol- CUP is a computational REASONS ogy would allow us to build compromising imaging technique, mea- much more compact sys- on performance.” suring the one-dimension- tems, without compromis- al intensity variation of a ing on performance. I’m LIHONG WANG. pulse of light over time and hopeful that developers of building upon it through laser sources will realize computation in order to the importance of this technology, and the scale of the ultimately visualize the pulse in two dimensions. REASON #2: new revenue channels that may emerge.” It could have several important applications, including in bioimaging; snapshots on this timescale could be THE BEST Biological guide star: valuable in fluorescence lifetime imaging, for example. PERFORMANCE whole body imaging? But other likely benefits could well be found in astrono- Outside of the direct work on photoacoustics, Wang’s my, where combining this degree of temporal resolution AT A BETTER PRICE current research topics include two areas likely to pro- with the spatial resolution available from instruments mote discussion at Photonics West. One involves using such as the Hubble Space Telescope could uncover new ultrasound as part of a method to create virtual guide- physical phenomena, or glimpse the very fast events star reference points within biological tissues, through occurring in supernova. wavefront engineering. Wang takes a holistic approach to these technologies, “I see this as the next growth area,” said Wang. “Im- looking for the common ground that they share. planting fluorophores within biological samples is inva- “My belief is that, in the end, all these techniques alluxa.com/reasons sive and not particularly flexible, effectively limiting the can and should work together, rather than displace each spot on which the microscopy technique can focus. Our other,” he said. “In my lab we built a tri-modality imaging 1-855-4ALLUXA method uses focused ultrasound to create a virtual guide system: we took a confocal and two-photon microscopy star, through the interaction of that ultrasound with a platform, and then added photoacoustic microscopy ca- beam of light. The basic principle can be implemented pability into the same system. So you could mount cells in a number of different ways.” or small animals on the same scanning stage and acquire This kind of wavefront engineering could ultimately information from three different contrast mechanisms. be of direct benefit to photoacoustic imaging, if it could That really summarizes my position. I think all technol- be used to counteract scattering and further increase ogies are, in the end, complementary.” TIM HAYES

Photoacoustic image of the vasculature in a mouse ear, acquired in vivo and without the use of an exogenous contrast agent. Credit: Song Hu and Lihong Wang, Washington University in St. Louis.

THIRD PhotonicsWest.indd 1 1/16/15 1:54 PM Sponsored Editorial

Supercontinuum goes violet Tamarisk®320 Precision Series Radiometric temperature Measurement with absolute clarity

DRS Technologies evolves its popular Tamarisk® line of 17µm, micro thermal imagers with the introduction of the Tamarisk® Precision Series for general purpose radiometric detection and imaging. Complete with unique features such as temperature ICE-o-Therms™ for Supercontinuum sources have been sources emitting in the entire 400-2400nm delineating multiple regions of interest commercially available for several years wavelength range. The sources are single- with user defined color parameters, providing high brightness laser output mode over the entire output spectrum dynamic range switching for optimal with tremendous spectral broadness and features a maintenance-free lifetime of performance from -40°C to +550°C and eclipsing even that of incandescent lamps. thousands of hours. The new sources can adjustable spotmeter for rapid temperature However, the spectral area below 430 nm be paired with variable filters, such as the measurement, Tamarisk® Precision Series has been challenging and many offerings SuperK SELECT or VARIA, to create a tunable enhances the OEM’s capabilities for a variety in the market have had sub-par stability, laser with a bandwidth covering the visible of applications. DRS’ proprietary radiometric lifetime and mode quality. With many and near-infrared part of the optical colorization works seamlessly with its Image applications, such as bio-imaging, material spectrum and due to the filter quality Contrast Enhancement (ICE™) algorithm to imaging, process monitoring and characterization and spectroscopy, moving and superior beam quality of the source, provide unmatched clarity and scene detail automation. to shorter wavelengths, the need for stable output stability is unrivaled in the industry. with true temperature measurement. With innovative detector design, precision single-mode sources in the 400nm region Both source and filter are controlled by Tamarisk® Precision Series is ideal for calibration techniques and stream-lined has increased and today NKT Photonics NKT Photonics new unified software suite, applications requiring location and manufacturing processes, Tamarisk® now - the World’s biggest manufacturer of CONTROL, making source and filter work as identification of key temperature variances offers unparalleled image quality coupled supercontinuum sources - addresses that one integrated system. to enable swift and accurate decisions need. with accurate radiometric temperature data. The new SuperK EXTREME EXU line of such as electrical and mechanical test With the introduction of the new violet supercontinuum sources are available now and measurement, building inspection, For more information on Tamarisk®320 SuperK EXTREME EXU series users now and is on display at NKT Photonics booth fire detection, general research and Precision Series cores from DRS Technologies, have access to diffraction limited laser #811. development, gas leak detection and visit www.drsinfrared.com.

Visit our booth North Hall #4318 CDA – We inspire and manufacture value! Optoelectronic components and microfunctional optofluidic devices in plastic

CDA GmbH (Suhl, Germany) is an established structures optimized to provide the best manufacturer of custom components and efficiency for the intended application. Custom solutions in plastic. CDA’s technology portfolio designed products include: includes polymer optical elements and arrays for DOEs (binary and multilevel) use in optoelectronics, automotive (HUD), virtual • Heads-up display gratings, line generators, etc. reality (VR) and 3D sensing applications. Portfolio • are becoming increasingly important where – design, prototyping, assembly and mass collimators, Fresnel lenses, custom lens arrays for microfluidic structures include channels, pillars, • chemical, electrical and/or optical properties production – are designed to benefit our functionalized surfaces sometimes combined • diffusers and mirrors need to be tested on a small scale. Tried and customers’ global strategy.” optical encoders tested structures and options include: • Contact A recent development is the ability to stack channels for separation and mixing • Booth: North Hall 4318 multiple optical layers in order to further hydrophobic and hydrophilic surfaces customize performance. • Pia Harju, Business Development Manager • combining these with microoptics and printed CDA GmbH, Am Mittelrain 11, Optical Module Assembly electronics 98529 Suhl, Germany CDA offers optical module design, prototyping Appropriate devices lend themselves well to high eMail: [email protected] and high volume assembly. These small levels of parallelization, thus reducing costs, but Web: www.cda-microworld.com integrated packages require often high precision their manufacture does require a fully integrated alignment between light source and optics process chain and command of several cutting- with conductive polymer printing for the use as well as proper packaging material for high edge microfabrication technologies. in point-of-care, diagnostics, environmental reliability and maximum performance. Manufacturing services monitoring and forensic screening applications. Microfluidic structures for ›lab-on-a-chip‹ According to Pia Harju, Business Development Optical elements CDA additionally provides the integration Manager at CDA, “The opportunities for both Individual elements can comprise diffraction- of microfluidic structures into compact and microoptical elements and for integrated devices limited refractive structures or diffractive sensitive devices, (›lab-on-a-chip‹). Such devices are truly global. Our manufacturing services

Photonics West: The world’s largest marketplace for photonics, optics, imaging, and industrial lasers Sponsored Editorial

Choosing a Digital Low Light Camera for Long Range Applications

The ability to observe and record images The two technologies most often used to and scenery undetected are paramount supplement CMOS or CCD low light digital to the safety of both life and infrastructure. imaging are thermal imaging and NIR Modern warfare techniques, whether static illumination. Thermal is good for detection monitoring or mobile surveillance, rely heavily and recognition as it relies on differences in on information gathered via covert long-range adjacent heat signatures. However, thermal surveillance methods such as hidden cameras. technologies do not showcase identifying The imaging technology is most effective if details, such as cultural signage or facial the camera can produce high quality long features, even at short range. range images in both daylight and nighttime NIR illumination is often used in static conditions. Today, the need to aggregate and surveillance to augment CCD daytime share information requires these long range imagery. This is ideal for short range imaging, Figure 1: Nocturn camera provides significantly longer identification under quarter moon lighting solutions to be digital. but the power required to illuminate at long conditions than competitive digital technologies and without supplemental technologies. Detection, Recognition and Identification are distances is impractical for mobile applications. critical in long range imaging, and each is It can also expose a location to danger, as any high speed imaging, without supplemental frame rates. Nocturn is offered in a wide dependent on proximity. Identification with reconnaissance with NIR sensitivity can clearly technology and without cooling. range of standard connectivity options, and high probability is a short-range function, identify a target. PHOTONIS is a global leader in low light some models can be ordered in color for as it needs a great level of detail and a high CMOS technology has emerged as a stand- technologies. Our expertise in night vision added certainty of identification in low light quality image to clearly determine if there alone digital low light imaging solution. The optics has made it possible to create a superior conditions. is a threat and what it may be. Identification solid state sensor is impervious to bright family of low light cameras that provide SXGA See for yourself at our live demo at Booth is most difficult under low-light conditions light damage, yet can provide superior, high resolution (1280x1024) with large 9.7 micron #4314. due to poor signal-to-noise ratio and most resolution and low noise images from full pixels for efficient light collection. The Nocturn digital surveillance cameras use supplemental daylight well into starlight conditions. CMOS family of low-light cameras offer <4e-rms at technologies to enhance low light imagery. sensors can provide high resolution and the full 100Hz, and supports common video The Ultimate Visible to Near Infrared Tunable Laser Source Based on Next Generation Supercontinuum Fiber Lasers High power Supercontinuum “white-light lasers” have proven to be popular and versatile light sources for research and industry. The latest WhiteLase™ supercontinuum sources from Fianium, with over 20W optical output, provide around three times more tunable power than any other similar system available. Figure 2: Plug-and-play LLTF Contrast™ Ross Hodder, Head of Sales & Marketing, Fianium Ltd tunable filter from Fianium.

Introduction in many applications only a single wavelength such a source depends on the type of filter and Summary Fianium (Southampton, UK) released the first is required at any one time and the rest of the the available power from the supercontinuum Supercontinuum white light fiber lasers are high power supercontinuum fiber laser in 2004 spectrum needs to be blocked. To achieve this a laser itself. The new WhiteLase™ SC-480- versatile light sources where the potential and have since supplied over 1200 WhiteLase™ tunable bandpass filter can be used converting 20 supercontinuum fiber laser provides an range of applications is defined by both the systems to customers around the world. the source into a cost-effective wide range unprecedented average power density of performance of the tunable filter and the light While the full broadband supercontinuum tunable picosecond laser. more than 10mW/nm, making it the brightest sources itself. The combination of the latest spectrum is sometimes used simultaneously, The amount of tunable power available from supercontinuum laser available today. generation WhiteLase™ supercontinuum fiber High performance “Laser Line” Tunable Filters lasers with high performance LLTF Contrast™ filter can provide greater than 10mW output, Grating based filters are used with in a narrow 2nm bandwidth, creating the supercontinuum lasers because of the ultimate tunable laser source. exceptionally high out-of-band suppression that can be achieved. Using holographic volume See Fianium’s latest products at Bragg gratings, out-of-band blocking of more Photonics West booth #829 than 60dB can be realised while maintaining the Fianium Limited spatially single-mode output. This technology Southampton, UK is now available in the LLTF Contrast™ compact plug-and play filter from Fianium. Email: [email protected] Another unique benefit of this type of filter is the Web: www.fianium.com extended tuning range with just two LLTF filter modules able to cover an impressive tuning range from 400nm to 2300nm.

Figure 1: Fianium WhiteLase SC-480-20 supercontinuum fiber laser.

Photonics West: The world’s largest marketplace for photonics, optics, imaging, and industrial lasers Booth 2611 South Hall FISBA - Global Market Leader Optical components for laser diode applications

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FISBA OPTIK AG www.fisba.com CH-9016 St. Gallen [email protected]

Lasermet-OpticsOrgAd-4.5'x6.5'.qx8_(v) 16/01/2015 09:52 Page 1

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Lasermet Inc. 10 N Martingale Road, Suite 400, Schaumburg, Illinois 60173 Visit us at Booth 5127 Office: 847 466 1077 Email: [email protected] www.lasermet.com/lasermetinc

Anzeige_ShowDaily_PW15_LM_OS_266_7x111_1mm_en_final.indd 3 13.01.2015 13:40:01 WEDNESDAY, FEBRUARY 11, 2015 | 27

New Gooch & Housego chief is cautiously optimistic for 2015 Recently installed CEO Mark Webster brings a healthcare background to the UK-headquartered photonics company as it looks to balance its applications base.

Despite an already solid business perfor- the Somerset town of Ilminster as 2014 Q-switches. But Webster explained that mance over the past year — sales up 11 per- drew to a close, Webster declared him- these devices now account for only around cent, earnings and dividends up 11 percent self optimistic about growing the G&H one-tenth of the company’s business. and 14 percent, respectively, and profits up business further. “I liked the look of this “We have fiber-optic capabilities at almost 20% — Gooch & Housego appears company, with its strong technology focus our Torquay, UK, site, which actually to be engaged in something of a reboot. and significant presence in the US and represents the fiber laser side of things, As of January 1 2015, the UK-based internationally,” he told Show Daily. “It while the fiber-optic Q-switch and fiber manufacturer of optical components and, has a good business strategy and under laser components represent about 12 per- Mark Webster was officially installed as increasingly, systems, has a new CEO in my predecessor, has been very adept at cent of our business now. So the business Gooch & Housego’s new CEO at the start Mark Webster. A seasoned executive with bringing on new technologies and I think is generally moving towards fiber-optics of 2015. His long-term predecessor, Gareth experience of refreshing the operations of also for predicting trends as well.” and away from the old style Q-switches. Jones, has now taken on the company chairman role. Credit: Gooch & Housego. some major pharmaceutical companies, Nor will that expertise be lost. Under “That’s still substantial business but it he is part of a senior executive rejig that the terms of the CEO succession, prede- won’t be the growth engine of the future. industrial sector growth which includes saw the long-term incumbent Gareth Jones cessor Jones will remain in place as G&H This business generally is moving towards fiber optics. shift to chairman responsibilities and the chairman for up to three years. fiber-optics.” “We would like to expand our relation- appointment of new COO Alex Warnock. To many specialist customers in G&H’s ship and develop a deeper relationship A chemist with a background in the core market sectors; aerospace and de- Deeper relationships with these companies. So we have put in international healthcare and pharma- fense, industrial lasers, life sciences, and Looking at the likely routes to grow- a couple of new people, one in the UK and ceuticals sectors, including senior roles scientific research, the company has typ- ing the business and considering Web- one in the US, who are very experienced at Abbott Laboratories, Bayer, Shire and ically been best-known for its solid-state ster’s healthcare and life sciences pedi- in aerospace and defense marketing. G&H Bio Products Laboratory, gree, does he expect that is already strong on ring laser gyroscope Webster had previously healthcare will become a systems, fiber gyroscopes and laser guid- become a non-executive more important market for ance systems for targeting.” director at G&H in Janu- G&H? In life sciences, the sales cycle typically ary 2012. He feels that his “In the short term, our involves a long gestation, so Webster sees track record in expanding main growth areas will be that market as a more of a medium-term technology-driven compa- in aerospace and defense, prospect. G&H technology is already in- nies means he is the right which is driven less by the stalled in OCT systems, particularly for man for the job of reinvigo- technology and more by ophthalmology but also for dermatology rating and streamlining an customer needs. We have applications, as well as laser surgery for enterprise that has grown already developed good varicose veins and prostate treatment, a diverse technology port- business relations with plus the booming aesthetic market of folio through numerous a number of key players. tattoo removal. In the future this could recent acquisitions. That sector will be fol- include diagnostic esophageal and car- Speaking at the compa- A wave plate manufactured at Gooch & Housego’s Cleveland, Ohio, facility. lowed by life sciences and diovascular procedures. ny’s rural headquarters in Credit: Gooch & Housego. there will also be niche continued on page 28

Anzeige_ShowDaily_PW15_LM_OS_266_7x111_1mm_en_final.indd 3 13.01.2015 13:40:01 28 | WEDNESDAY, FEBRUARY 11, 2015

Mark Webster continued from page 27 going to provide some systems growth, but only part of that site In the longer term, Webster sees a development capability in the is modern, so we have taken the fruitful market in optical systems for line- US and Murray Reed, our CTO, decision to upgrade the rest.” of-sight satellite communications. It was is looking into how we can do Considering possible person- with this in mind that G&H acquired the that.” One possibility is to site nel changes, he added, “We want Greek space technology start-up Constel- an additional electronics de- to make G&H more efficient. My ex in late 2013. Bought for €600,000, it velopment group in the US, game-plan is to add a small num- has since been integrated into the com- perhaps in the company’s new ber of people, who have skills and pany’s Torquay operation. Fremont, California, location experience that we perhaps don’t “Constelex already had some that should open for business have already, for example in aero- grant-funded business with the Europe- in April after relocating from space and defense areas, people an Space Agency,” Webster said. “Space nearby Palo Alto. who are experienced in working applications play to our strengths because Besides aiming for organic with the larger aerospace and it’s a hostile environment; you need to deal growth through the develop- defense companies.” Besides se- with radiation and high temperature fluc- ment of that internal systems lected personnel, G&H will also tuations, and the systems are not read- capability, G&H is also keen to be increasing its research and ily repairable. We are already investing continue making some strategic development budget percentage Production of a fused optical coupler at Gooch & Housego’s in space and satellite but that market is acquisitions. Along with Con- Ilminster, UK, headquarters. Credit: Gooch & Housego. from the 8 percent of sales invest- probably three to five years down the line.” stelex, the most recent of those ed in 2014. was in late 2013, when Spanoptic, based “Improving the fit of our divisions Webster believes that G&H has his- Systems technology in Glenrothes near Edinburgh, became is another of my objectives,” he admits. torically done a good job of anticipating One key objective of Webster’s is to repo- part of the group. “Bringing them together better is some- trends in the photonics marketplace. So sition the company’s components-to-sys- Spanoptic makes aspherical optics, thing I’m looking at. It’s true that in some what does his crystal ball tell him now? tems sales revenue split. Currently, that complementing the planar optics produced of the larger companies I have worked for “We are looking at the market in 2015 sits at 80:20 in favor of components, and back at the Ilminster headquarters, as well that when you make acquisitions, there with cautious optimism,” he says. “If we the aim is to achieve a notional balance as infrared components — a good fit for the is a job to achieve integration. So far, we look at the broader macro trends — aero- of 50:50. “The thinking behind expanding defense market. Despite being at opposite have managed to make all of the units space and defense, the US budget is now our Systems Technology Group [STG] is ends of the UK geographically, the Ilmin- deliver profit. confirmed for the year, so that is good that while G&H is well-known for produc- ster and Glenrothes sites are now treated “Perhaps what we have been less good news. But we do not expect the defense ing high-quality components and working as a single “virtual” business unit. at is bringing them all together to create a budget to grow dramatically. with customers on their systems, we have single G&H company, so the feeling would “The sectors in which we operate, where been less effective at putting the systems Integration challenge be that if we can leverage the capabilities customers still tend to be upgrading to fi- together ourselves. But the various additions made in recent that we have across the piece and pres- ber-optic technologies, seem to be good “The STG, at Torquay, now consists of years have inevitably been accompanied ent them as a single package to customers for us. In the life sciences area, that tends 11 people and it’s growing rapidly. It has by some logistical headaches, and even the then we would have a stronger and better to be affected by budgets, but again the PhD scientists and engineers but it also has company’s 2014 annual report included company.” trend towards lasers for surgery and for electronics and software engineers and we the frank admission that the G&H board At present, there are no plans for con- OCT for diagnostics also seems to be on are actively recruiting more of these. We of directors “believed that the group had solidation beyond the closure of the Florida a good pathway. On the industrial side, have been reasonably successful putting too many operating sites leading to inef- site. And another recent decision will re- I think there are areas that are showing together some systems in, for example, ficiencies.” The Melbourne, Florida, site sult in a significant investment to upgrade good growth. Fiber lasers, because they OCT, fiber-optics and satellite applica- has already been deemed surplus to re- the company’s crystal and electro-optics are relatively lower cost, are also becom- tions. It’s not the bulk of our business but quirements, but does Webster feel that the facility in Cleveland, Ohio. Webster coming more ubiquitous. The breadth of their we want it to be more significant. company’s still-diverse range of technolo- mented, “Cleveland is a very productive usage will continue to increase.” “We also need to consider how we are gies and locations needs further pruning? and profitable site, with good revenue MATTHEW PEACH

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problems in cancer biology. Analysis of He said test kits would reach the US Hot Topics shine a light interference spectra is converted to statis- medical marketplace, starting with a tar- tical properties, and inside one minute the get of heavy smokers, as early as 2016, system can image 100 cells, showing nu- with colon cancer screening tests to follow on early cancer detection cleic architecture and nano-scale changes soon. Start-up company Nanocytomics is White lights, blue lights and the “colors” and she could quantify it with a ground- in chromatin in real time. commercializing the tests, which are now of collagen lit up the BiOS Hot Topics ses- breaking optical approach. The results, That reveals changes in nuclear and in clinical trials. sion on the opening evening of Photonics also showing breast tissue density with- cell architecture an order of magnitude “This is how to win the war on cancer,” West 2015, as two speakers on non-inva- out incisions, are dramatic, said Taroni, below the resolution of conventional mi- claimed Backman, who studied medicine sive cancer screening showed how optical although she added: “We have years to go croscopy, while the technique lets physi- and engineering at Harvard and MIT. The tools could break through old logjams in before it will help patients.” cians identify pre-cancerous tissue that goal is not just to track existing cancers clinical medicine. She said that high false positive rates would otherwise be missed. but “to prevent cancer from happening in Other speakers in the round-robin, - up to 30 percent, for in fact benign cells Backman said: “A big plus of our nano- the first place.” with only 15 minutes per talk, told how - showed a need for better non-invasive cytology technique is that not only it can Aside from Backman and Taroni, the optics can spot otherwise hidden brain discrimination of malignant lesions. identify early pre-cancerous lesions by session featured talks on endoscopic tumors and how adaptive optics (AO) can Meanwhile, a talk on general ear- analysis of easily accessible cells - checking OCT, adaptive optics for retinal screen- assess complex eye diseases. ly-stage cancer detection revealed the for lung cancer, or colon cancer - but it can ing, and 3D imaging of neural activity, Paola Taroni from the Politecnico di first nanoscale measurement, chroma- identify clinically significant and potential- while Lihong Wang picked up the 2015 Milano in Italy described a 200-patient tin-based and “label free,” of cancer’s ac- ly dangerous lesions, even when these are Britton Chance Biomedical Optics Award study on collagen, saying her use of light tivity inside cells. “It’s what bioscience has small and can be removed easily.” (see our interview with Wang on page 21 at specific wavelengths was the first clin- needed and waited for, for a long time,” Chromatin structure drives changes in of this issue). Symposium co-chair Rox ical work on such a non-invasive way to said Vadim Backman, a biomedical engi- genetic networks, Backman said, letting Anderson told the conference: “I love the look for breast cancer. neer at Northwestern University. “Every cells loose to “explore the genomic land- melting pot that the SPIE has become. Because collagen, an agent in breast other method uses labels that change the scape, what cancer is all about.” Those We are actually making a difference for cancer, absorbs light so differently from cell function.” structures can be modulated with drugs, he people in the world and what better for other tissue constituents, her images His approach instead looks at chro- said, and 90 percent of cancer deaths could the [International] Year of Light.” showed it clearly, in contrasting colors, matin structure to address fundamental be avoided with better early screening. FORD BURKHART Cylite takes tomography “hyperparallel” Cylite, a company from Melbourne, Aus- “[Its] capabilities include greatly en- modalities such as elastography tralia, used the BiOS Expo to demonstrate hanced frame registration due to multi- and Doppler OCT.” its new “hyperparallel” coherence tomog- ple simultaneous surface measurements, The technique has yet to raphy measurement and analysis platform. denser volumetric imaging over a fine be trialed on a representative The 3D spectral imaging technology, lateral grid. Overall it is a lower-cost human sample, although the with potential applications in optometry implementation because we use stan- development team says that and other biological fields, scans tissues dard optical components and achieve under the guidance of a profes- across a roughly cornea-sized (15mm x the functionality of three conventional sional optometrist (who is on 9mm) grid, performing more than 1000 instruments in one,” he said. the company’s advisory board) simultaneous high-resolution scans to a Steve Frisken, the company’s CEO, add- they have tried it on each other depth of 7.5 mm at over 50 frames per ed, “Hyperparallel coherence tomography — with promising results. One second. provides a definitive solution for the grow- specific application of the kit Armin Segref (l) and development director Trevor Anderson from Cylite at the weekend’s BiOS Expo. Trevor Anderson, Cylite’s research and ing requirements of high-resolution optical could be diagnosis of keratoco- Credit: Matthew Peach development director, told Show Daily, imaging tomography and metrology. It en- nus, which causes a variety of “This degree of scanning provides several ables the capture of en-face images in a sin- sight problems including blurred vision, presented the technique in a paper at the enhanced performance features from a gle shot with phase registration over a full increased sensitivity and “ghosting.” associated conference, entitled “3D spectral single tool, which we believe is unique in C-scan. This provides unique capabilities Besides introducing the hyperparallel imaging for anterior segment metrology.” the field. that could also be applied to advanced OCT approach at the BiOS Expo, Anderson also MATTHEW PEACH

Turnover up sharply at ALPAO ALPAO showed off its adaptive optics technology large part to demand for medical applications, on the show floor with an interactive demo in which now make up more than half of ALPAO’s which attendees could control the company’s de- total sales. formable mirrors through a simple iPad interface. Astronomy and microscopy make up the other This year the French firm, a spin-out from Jo- two major application sectors for adaptive optics, seph Fourier University in Grenoble, was high- and one of ALPAO’s deformable mirrors is used lighting its two latest deformable mirrors, which in the 8.2 meter diameter Subaru telescope at the feature 468 and 820 actuators. Sales manager summit of Mauna Kea in Hawaii. The company Vincent Hardy said that he is targeting appli- is likely to be one of those competing to provide Edmund Optics and LUXeXceL have signed a collaborative agreement to work together on 3D-printed optical components. They are cations in ophthalmology, where ALPAO has state-of-the-art adaptive optics technology for the demonstrating a lens array comparison during the Photonics West developed a 97-actuator deformable mirror that European Extremely Large Telescope (E-ELT) exhibition to show the performance of the emerging technology. is the same size as a dilated pupil. in Chile, which is set to use a 2.6 meter adaptive Netherlands-based LUXeXceL is also a Prism Award finalist this week. See Edmund at booth 1615. Credit: Trish Tunney. The company saw its turnover jump 50 percent mirror in conjunction with six laser guide stars last year to around €1.5M, Hardy said, thanks in to correct for atmospheric turbulence.

Photonics West: The world’s largest marketplace for photonics, optics, imaging, and industrial lasers 34 | WEDNESDAY, FEBRUARY 11, 2015

Intellectual Ventures has invested more Biophotonics startups, established firms than $2 billion in patents over the years. The company also sells patent portfolios to small companies that have started recently consider numerous financing options and don’t yet have good patent protection. Opportunities abound for lasers and opto- ments, much of the investment is also go- firms to date. The company’s sources of However, IP is much broader than electronics in the life sciences and health- ing into fluorescence-based devices, such financing include angels, non-dilutive just patents, Salesin noted. It includes care markets, but the financial landscape as drug discovery platforms and equip- sources, strategic alliances, and VC. software, trademarks, trade secrets, can be tricky to navigate, especially for ment used for environmental analysis. “We would love to see more venture copyrights, domain names, social media small- to medium-sized companies. That’s Even so, the biophotonics landscape capital involved in our deals, but that mar- profiles, databases, IP addresses, even why finding the right investors and busi- continues to be centered around a few key ket has changed quite a bit,” Bashi said. “In spectrum rights — all things that are not ness model to successfully bring a new players and hundreds of small-to-medium fact, the VC industry is redefining itself, on a company’s balance sheet but that product to market is critical — even for enterprises and startups. In fact, Smith’s represent value. ventures that are well beyond the startup 2014 analysis found an interesting trend. “All of these things have value down the stage, according to speakers at a photon- In 2013, more than 90 percent of private road if you want to raise money for your ics industry session Tuesday on financing placements were made in early-stage business in a non-dilutive way,” he said. life sciences and healthcare ventures. companies with less than $10 million in Another financing option to consider is The market for private placements in revenues and no earnings. But in 2014, loan debt (versus equity), which tends to development-stage and high-growth life this number dropped to 15 percent, with be more attractive for larger companies. science and healthcare businesses is “ro- a significantly higher concentration of in- “Banks offer a broad source of capital bust,” according to panel moderator Linda vestments in companies with more than from a debt standpoint,” said panelist Jim Smith, president of Ceres Tech Advisors, $10 million in revenues. Haack, senior vice president of technology an acquisitions advisory firm that special- “In this market, the business models to banking at Citibank. “Debt can be a very izes in photonics. Smith, who compiles an get a company from the startup stage to low-cost source of capital, even lower cost annual list of mergers, acquisitions, and a $5-to-$10 million dollar company with than equity.” private placements made in biophotonics, customers and FDA approval is a chal- With the changing healthcare land- said she found over $5 billion worth of in- lenge,” she said. “So whether you are a scape, health systems, such as doctors, vestment in biotech-enabled businesses in startup or an established player, access hospitals, cancer centers, and medical 2014 — three times the investment in 2013. to capital is extremely important.” schools, represent an emerging source “Biophotonics is a core enabling tech- of investment for companies developing nology for many innovations in healthcare Financing options products that can improve patient care and life sciences and fertile ground for in- Fortunately, a variety of financing options and lower costs, according to Chuck Sted, vestment and economic growth,” she said. are available, ranging from venture capi- Core enabler: biophotonics is critical to former CEO of Hawaii Pacific Health. According to Smith’s analysis, diagnos- tal and private equity to strategic corpo- many innovations in healthcare and life With the shift from fee-for-service reim- tics accounted for 40 percent of private rate investing, venture debt, angel invest- sciences. Credit: Trish Tunney bursement to payment for value, the cost placements ($1.6 billion) in 2014, domi- ing, and patent licensing. for lack of a better word. In 2007 there of healthcare is shifting from payers to nated by fluorescence-based technologies, Angel investing has become an in- were more than 1,100 VC funds; today less providers. Thus there is growing interest molecular imaging, and point-of-care de- creasingly attractive option, given the than half that. And the remaining VCs have by health systems large and small to sup- vices. In fact, her survey found 50 invest- changing venture capital (VC) industry, moved away from smaller ($1 million to $5 port innovation, Sted emphasized. ments in point of care devices alone. according to Faz Bashi, chair of the Dig- million) investments and are waiting for KATHY KINCADE Investments in medical imaging were ital Health & Sciences Committee at Life later rounds. And many VCs have moved also significantly higher than in previ- Science Angels. Life Science Angels is a away from the life science space.” ous years, up 26 percent over 2013, with nonprofit pro bono operation with about As a result, angel investment groups “good, healthy investments” still taking 100 investors that is supported by mem- have become “quite significant,” Bashi place in optical coherence tomography bership fees and sponsorships. The com- said, noting that in 2010, angel investors and endoscopy. In life sciences, which ac- pany looks for deals where it can provide accounted for more than $20 billion in counted for 15 percent of private place- expertise and capital and has funded 42 investments in more than 61,000 deals — numbers that remain about the same today. When considering a potential invest- PUBLISHED BY: Smartphones used in Haiti ment, Life Science Angels is interested in SPIE, 1000 20th Street much more than just a company’s busi- Bellingham WA 98225 USA Tel: +1 360 676 3290 for cancer screening ness plan, Bashi emphasized. www.spie.org Christophe Millien of the Hôpital munities where there are no clin- “We are interested not just in money Universitaire de Mirebalais in Hai- ics or doctors. Haiti is estimated capital but in psychological, human, and EDITORIAL: ti described a handheld, smart- to have a cervical cancer rate 10 social capital,” he said. “These are the Original Content Ltd. phone-based colposcope system times higher than the state of Ken- things that go into making a company suc- Tel: +44 (0)117 939 4887 used by mobile clinics in Haiti that tucky in the USA. cessful.” Bashi added that 70 to 80 per- is enabling screening for cervical The modified smartphone and cent of “why we invest is management.” ADVERTISING SALES: cancer — and resulting in saved accompanying software provide Another option for financing and man- Lucent Media Tel: +44 (0)117 905 5330 lives among a high-risk and un- an easy-to-use, transportable col- aging your business is to consider licens- derserved population. poscope with which nurses and ing or selling your intellectual property PRODUCTION & PRINTING: “Poverty is a carcinogen,” midwives can capture and share (IP), according to Jeremy Salesin, VP of Tradeshow Media Partners Millien noted in a conference on medical images with doctors in acquisitions for Intellectual Ventures, 81 Lansing Street, Suite 206 optics and biophotonics in low-re- Haiti and the USA, resulting in which manages over 40,000 assets and li- San Francisco, CA 94105 source settings. Millien said cer- more accurate diagnoses and censes them to companies to help manage Tel: +1 415 371 1525 vical cancer is a leading cause of successful treatment. their risk and maintain their advantage. cancer death for women in com- AMY NELSON “Patent transactions are an interesting way of raising money,” he said, noting that

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