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Clinical Chemistry June 1 2007, Volume 53, Issue 6,pp.999- 1180 Editorials Andrew McCaddon and Peter R. Hudson Methylation and Phosphorylation: A Tangled Relationship? Clin Chem 2007 53: 999-1000. Bob Palais Quantitative Heteroduplex Analysis Clin Chem 2007 53: 1001-1003. Eleftherios P. Diamandis Oncopeptidomics: A Useful Approach for Cancer Diagnosis? Clin Chem 2007 53: 1004-1006. Roger D. Klein The Pain Protective Haplotype: Introducing the Modern Genetic Test Clin Chem 2007 53: 1007-1009. Molecular Diagnostics and Genetics Jörn Lötsch, Inna Belfer, Anja Kirchhof, Bikash K. Mishra, Mitchell B. Max, Alexandra Doehring, Michael Costigan, Clifford J. Woolf, Gerd Geisslinger, and Irmgard Tegeder Reliable Screening for a Pain-Protective Haplotype in the GTP Cyclohydrolase 1 Gene (GCH1) Through the Use of 3 or Fewer Single Nucleotide Polymorphisms Clin Chem 2007 53: 1010-1015. Published online March 15, 2007; 10.1373/clinchem.2006.082883 Kerstin L. Edlefsen, Jonathan F. Tait, Mark H. Wener, and Michael Astion Utilization and Diagnostic Yield of Neurogenetic Testing at a Tertiary Care Facility Clin Chem 2007 53: 1016-1022. Published online April 19, 2007; 10.1373/clinchem.2006.083360 Sara Bremer, Helge Rootwelt, and Stein Bergan Real-Time PCR Determination of IMPDH1 and IMPDH2 Expression in Blood Cells Clin Chem 2007 53: 1023-1029. Published online April 26, 2007; 10.1373/clinchem.2006.081968 Elizabeth Herness Peters, Sandra Rojas-Caro, Mitchell G. Brigell, Robert J. Zahorchak, Shelley Ann des Etages, Patricia L. Ruppel, Charles R. Knight, Bradley Austermiller, Myrna C. Graham, Steve Wowk, Sean Banks, Lakshmi V. Madabusi, Patrick Turk, Donna Wilder, Carole Kempfer, Terry W. Osborn, and James C. Willey Quality-Controlled Measurement Methods for Quantification of Variations in Transcript Abundance in Whole Blood Samples from Healthy Volunteers Clin Chem 2007 53: 1030-1037. Published online April 13, 2007; 10.1373/clinchem.2006.078154 Sung Jae Kim, David J. Dix, Kary E. Thompson, Rachel N. Murrell, Judith E. Schmid, Jane E. Gallagher, and John C. Rockett Effects of Storage, RNA Extraction, Genechip Type, and Donor Sex on Gene Expression Profiling of Human Whole Blood Clin Chem 2007 53: 1038-1045. Published online April 13, 2007; 10.1373/clinchem.2006.078436 Kok Seong Lim, Robert K. Naviaux, and Richard H. Haas Quantitative Mitochondrial DNA Mutation Analysis by Denaturing HPLC Clin Chem 2007 53: 1046-1052. Published online April 19, 2007; 10.1373/clinchem.2006.083303 Hemostasis and Thrombosis Isabella Russo, Paola Del Mese, Gabriella Doronzo, Alessandro De Salve, Mariantonietta Secchi, Mariella Trovati, and Giovanni Anfossi Platelet Resistance to the Antiaggregatory Cyclic Nucleotides in Central Obesity Involves Reduced Phosphorylation of Vasodilator-Stimulated Phosphoprotein Clin Chem 2007 53: 1053-1060. Published online April 26, 2007; 10.1373/clinchem.2006.076208 Proteomics and Protein Markers Yuan-Yuan Li, Chi Zhang, Bo-Sheng Li, Li-Fan Zhao, Xiao-bo Li, Wen-Jie Yang, and Shun-Qing Xu Ultrasensitive Densitometry Detection of Cytokines with Nanoparticle- Modified Aptamers Clin Chem 2007 53: 1061-1066. Published online April 19, 2007; 10.1373/clinchem.2006.082271 Mary F. Lopez, Alvydas Mikulskis, Scott Kuzdzal, Eva Golenko, Emanuel F. Petricoin, III, Lance A. Liotta, Wayne F. Patton, Gordon R. Whiteley, Kevin Rosenblatt, Prem Gurnani, Animesh Nandi, Samuel Neill, Stuart Cullen, Martin O’Gorman, David Sarracino, Christopher Lynch, Andrew Johnson, William Mckenzie, and David Fishman A Novel, High-Throughput Workflow for Discovery and Identification of Serum Carrier Protein-Bound Peptide Biomarker Candidates in Ovarian Cancer Samples Clin Chem 2007 53: 1067-1074. Published online April 26, 2007; 10.1373/clinchem.2006.080721 Winfried März, Beate Tiran, Ursula Seelhorst, Britta Wellnitz, Johann Bauersachs, Bernhard R. Winkelmann, and Bernhard O. Boehm N-Terminal Pro-B-Type Natriuretic Peptide Predicts Total and Cardiovascular Mortality in Individuals with or without Stable Coronary Artery Disease: The Ludwigshafen Risk and Cardiovascular Health Study Clin Chem 2007 53: 1075-1083. Published online April 19, 2007; 10.1373/clinchem.2006.075929 Cancer Diagnostics Maureen Cronin, Chithra Sangli, Mei-Lan Liu, Mylan Pho, Debjani Dutta, Anhthu Nguyen, Jennie Jeong, Jenny Wu, Kim Clark Langone, and Drew Watson Analytical Validation of the Oncotype DX Genomic Diagnostic Test for Recurrence Prognosis and Therapeutic Response Prediction in Node- Negative, Estrogen Receptor–Positive Breast Cancer Clin Chem 2007 53: 1084-1091. Published online April 26, 2007; 10.1373/clinchem.2006.076497 Lipids, Lipoproteins, and Cardiovascular Risk Factors Ji-Sun Lim, Duk-Hee Lee, Joo-Yun Park, Soo-Hee Jin, and David R. Jacobs, Jr A Strong Interaction between Serum -Glutamyltransferase and Obesity on the Risk of Prevalent Type 2 Diabetes: Results from the Third National Health and Nutrition Examination Survey Clin Chem 2007 53: 1092-1098. Published online May 3, 2007; 10.1373/clinchem.2006.079814 Hematology Christine L.H. Snozek, Amy K. Saenger, Philip R. Greipp, Sandra C. Bryant, Robert A. Kyle, S. Vincent Rajkumar, and Jerry A. Katzmann Comparison of Bromcresol Green and Agarose Protein Electrophoresis for Quantitation of Serum Albumin in Multiple Myeloma Clin Chem 2007 53: 1099-1103. Published online April 26, 2007; 10.1373/clinchem.2007.088252 Endocrinology and Metabolism Isolde Seiden-Long and Reinhold Vieth Evaluation of a 1,25-Dihydroxyvitamin D Enzyme Immunoassay Clin Chem 2007 53: 1104-1108. Published online April 13, 2007; 10.1373/clinchem.2006.077560 Tim Cundy, Anne Horne, Mark Bolland, Greg Gamble, and James Davidson Bone Formation Markers in Adults with Mild Osteogenesis Imperfecta Clin Chem 2007 53: 1109-1114. Published online April 13, 2007; 10.1373/clinchem.2006.083055 Automation and Analytical Techniques Joris R. Delanghe, Anders Helander, Jos P.M. Wielders, J. Maurits Pekelharing, Heinz J. Roth, François Schellenberg, Catherine Born, Eray Yagmur, Wolfgang Gentzer, and Harald Althaus Development and Multicenter Evaluation of the N Latex CDT Direct Immunonephelometric Assay for Serum Carbohydrate-Deficient Transferrin Clin Chem 2007 53: 1115-1121. Published online April 5, 2007; 10.1373/clinchem.2006.084459 General Clinical Chemistry John Mahoney and John Ellison Assessing the Quality of Glucose Monitor Studies: A Critical Evaluation of Published Reports Clin Chem 2007 53: 1122-1128. Published online May 3, 2007; 10.1373/clinchem.2006.083493 Rima Obeid, Mariz Kasoha, Jean-Pierre Knapp, Panagiotis Kostopoulos, George Becker, Klaus Fassbender, and Wolfgang Herrmann Folate and Methylation Status in Relation to Phosphorylated Tau Protein(181P) and ß-Amyloid(1–42) in Cerebrospinal Fluid Clin Chem 2007 53: 1129-1136. Published online March 23, 2007; 10.1373/clinchem.2006.085241 Clinical Immunology Jochen Metzger, Philipp von Landenberg, Marcus Kehrel, Alexander Buhl, Karl J. Lackner, and Peter B. Luppa Biosensor Analysis of ß2-Glycoprotein I–Reactive Autoantibodies: Evidence for Isotype-Specific Binding and Differentiation of Pathogenic from Infection-Induced Antibodies Clin Chem 2007 53: 1137-1143. Published online April 13, 2007; 10.1373/clinchem.2006.079632 Nutrition Dolores Corella, Donna K. Arnett, Michael Y. Tsai, Edmond K. Kabagambe, James M. Peacock, James E. Hixson, Robert J. Straka, Michael Province, Chao-Qiang Lai, Laurence D. Parnell, Ingrid Borecki, and Jose M. Ordovas The –256T>C Polymorphism in the Apolipoprotein A-II Gene Promoter Is Associated with Body Mass Index and Food Intake in the Genetics of Lipid Lowering Drugs and Diet Network Study Clin Chem 2007 53: 1144-1152. Published online April 19, 2007; 10.1373/clinchem.2006.084863 Technical Briefs Dihua Shangguan, Zehui Charles Cao, Ying Li, and Weihong Tan Aptamers Evolved from Cultured Cancer Cells Reveal Molecular Differences of Cancer Cells in Patient Samples Clin Chem 2007 53: 1153-1155. Published online April 26, 2007; 10.1373/clinchem.2006.083246 Joseph Skulan, Thomas Bullen, Ariel D. Anbar, J. Edward Puzas, Linda Shackelford, Adrian LeBlanc, and Scott M. Smith Natural Calcium Isotopic Composition of Urine as a Marker of Bone Mineral Balance Clin Chem 2007 53: 1155-1158. Published online April 26, 2007; 10.1373/clinchem.2006.080143 Letters to the Editor Giovanni Targher, Massimo Franchini, Gian Cesare Guidi, Michele Muggeo, and Giuseppe Lippi Alanine Aminotransferase as an Independent Predictor of Incident Nonalcoholic Fatty Liver Disease Clin Chem 2007 53: 1159. Yoosoo Chang, Seungho Ryu, Eunju Sung, and Yumi Jang Reply to Alanine Aminotransferase as an Independent Predictor of Incident Nonalcoholic Fatty Liver Disease Clin Chem 2007 53: 1159-1161. Mads V. Hollegaard, Karina M. Sørensen, Høgni K. Petersen, Maria B. Arnardottir, Bent Nørgaard-Pedersen, Poul Thorsen, and David M. Hougaard Whole Genome Amplification and Genetic Analysis after Extraction of Proteins from Dried Blood Spots Clin Chem 2007 53: 1161-1162. Francisco J. Morón, Nicolás Mendoza, Francisco Quereda, Francisco Vázquez, Reposo Ramírez-Lorca, Juan Velasco, Jose L. Gallo, Ana Salinas, Txantón Martínez-Astorquiza, Rafael Sánchez-Borrego, Maria E. Sáez, and Agustín Ruiz Pyrosequencing Technology for Automated Detection of the BMP15 A180T Variant in Spanish Postmenopausal Women Clin Chem 2007 53: 1162-1164. David Friedecky, Jana Tomkova, and Tomas Adam Determination of ITPase Activity by Capillary Electrophoresis Clin Chem 2007 53: 1164-1165. Vivienne M. Homer and Peter M. George Novel Mutation (c.G1124A) in Exon 9 of the APOB
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