Four SeparateSources, Andersonetal.Molec.Cell. Proteomics,inpressFeb2004 The HumanPlasma Proteome:ANon-RedundantList DevelopedbyCombinationof Q13200 P35998 NP_006178 P29728 P00973 Q9C0C2 P29312 candidate plasmacomponentssubjecttoconfirmation. number ofthe980accessionsfoundinonlyonedatasetcouldresultfromMSidentificationerrors,readershouldviewtheseas all 1175non-redundantaccessions,ofwhichonly195aredetectedinmorethanonesource(total_sources>1).Sinceasubstantial Joshua N.Adkins,JoelG.Pounds,RichardFagan,andAnnaLobley(MolecularCellularProteomics,inpress(Feb2004).Thetablelists by N.LeighAnderson,MaluPolanski,RembertPieper,TinaGatlin,RadhakrishnaS.Tirumalai,ThomasP.Conrads,TimothyD.Veenstra, Supplemental DataTablefrom"TheHumanPlasmaProteome:ANon-RedundantListDevelopedbyCombinationofFourSeparateSources" NP_005711 NP_006400 NP_055412 NP_001084 NP_000010 Q9Y4K1 NP_005742 NP_006729 NP_009133 NP_112217 NP_068369 P14780 P11021 P08253 AAB27045 P10809 P34969 I53328 NP_000182 NP_000850 A36317 P55036

Accession

0 0 0 0 0 0 0 0 0 0 0 1 0 1 0 1 0 0 0 0 0 1 0 0 0 1 1 0 0 Lit 0 1 1 0 0 0 1 1 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 2DEMS 0 0 0 0 0 1 1 1 0 1 0 0 0 0 0 0 0 1 1 1 1 0 0 1 0 0 0 0 0 LCMS1

1 1 0 0 0 1 0 1 1 1 1 0 0 0 1 1 0 0 1 1 0 0 0 0 1 0 0 0 0 LCMS2 1 1 1 1 1 1 1 1 1 1 1 1 1 2 3 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Total_accessions 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 3 1 1 1 1 1 1 1 1 1 1 1 Total_sources no no no no no no signal confident no no no no no possible signal signal confident signal confident signal confident signal confident possible signal no no no signal signal no no no no no no

Signal 0 0 7 0 0 5 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 TM 70-kd peroxisomalmembranceproteinhomolog{internal ) (hucha60). 60) (MitochondrialmatrixproteinP1)(P60lymphocyte (60 kdachaperonin)(CPN60)(Heatshockprotein60)(HSP- 60 kdaheatshockprotein,mitochondrialprecursor(Hsp60) (Serotonin receptor)(5HT7). 5-hydroxytryptamine 7receptor(5-HT-7)(5-HT-X) human(fragment) 4-aminobutyrate aminotransferase,neuroblastomaBEcells- 3-hydroxymethyl-3-methylglutaryl-Coenzyme Alyase sapiens]. 3-hydroxy-3-methylglutaryl-Coenzyme Areductase[Homo 3.1.4.17),camp-specific -human 3',5'-cyclic-nucleotide phosphodiesterase(EC chain bindingprotein)(Antisecretoryfactor-1)(AF)(ASF). proteasome regulatorysubunitS5A)(Rpn10)(Multiubiquitin 26S proteasomenon-atpaseregulatorysubunit4(26S associated protein2)(55.11protein). subunit p97)(Tumornecrosisfactortype1receptor proteasome regulatorysubunitS2)(26S 26S proteasomenon-atpaseregulatorysubunit2(26S 26S proteaseregulatorysubunit7(MSS1protein). synthetase 3 2'-5'oligoadenylate synthetase3;2'-5'-oligoadenylate p71 OAS)(p69oas/p71oas). 5')oligo(A) synthetase2)(2-5A(p69OAS/ 2'-5'-oligoadenylate synthetase2(EC2.7.7.-)((2- OAS) (E18/E16). 5')oligo(A) synthetase1)(2-5A(p46/p42 2'-5'-oligoadenylate synthetase1(EC2.7.7.-)((2- 182 kdatankyrase1-bindingprotein. 1) (KCIP-1)(FactoractivatingexoenzymeS)(FAS). 14-3-3 proteinzeta/delta(ProteinkinaseCinhibitorprotein- protein relatedprotein2/3complex subunit1B;ARP2/3 protein Actin relatedprotein2/3complex subunit1A;actinbinding Acidic 82kdaproteinmrna[Homo sapiens]. Acetyl-Coenzyme Acarboxylasebeta [Homosapiens]. acetoacetyl Acetyl-Coenzyme Aacetyltransferase 1precursor; Absent inmelanoma1protein. anchoring A kinaseanchorprotein9isoform2;yotiao;A-kinase anchoring A kinase(PRKA)anchorprotein13isoform1;A-kinase specificity A kinase(PRKA)anchorprotein10precursor;dual type 1 A disintegrin-likeandmetalloproteasewiththrombospondin proprotein; A disintegrinandmetalloproteinasedomain22isoform1 (Gelatinase B)(GELB). kda gelatinase)(Matrixmetalloproteinase-9)(MMP-9) 92 kdatypeIVcollagenaseprecursor(EC3.4.24.35)(92 grp78). (Endoplasmic reticulumlumenalCa2+bindingprotein (Immunoglobulin heavychainbindingprotein)(BIP) 78 kdaglucose-regulatedproteinprecursor(GRP78) (Gelatinase A)(TBE-1). kda gelatinase)(Matrixmetalloproteinase-2)(MMP-2) 72 kdatypeIVcollagenaseprecursor(EC3.4.24.24)(72 fragment}

Description Page 1,H_Plasma_NR Table Four SeparateSources, Andersonetal.Molec.Cell. Proteomics,inpressFeb2004 The HumanPlasma Proteome:ANon-RedundantList DevelopedbyCombinationof Q15848 P40123 Q9Y6K8 NP_004027 S35534 P23526 P00813 NP_000029 O94973 O43747 Q15650 P02570 P26232 NP_000669 P04217 P01009 P01011 P02763 P51993 I37141 NP_004360 NP_001845 P05186 P05187 O94788 AAB27176 AAB21839 P24298 O00253 NP_006787 NP_001124 NP_004305 XP_039813 Q9UJY4 P35318

Accession

0 0 1 1 1 1 1 0 0 0 1 0 0 0 0 1 1 0 0 0 0 0 1 1 0 0 0 0 0 1 0 0 0 0 2 Lit 0 0 1 1 1 0 0 1 0 0 0 0 0 4 0 0 1 1 1 1 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 2DEMS 0 0 1 0 0 0 0 1 0 1 1 2 1 0 1 1 1 0 1 1 1 1 0 0 0 1 1 0 0 0 0 0 0 0 0 LCMS1

0 1 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 1 1 0 0 0 0 1 1 0 0 0 1 1 1 2 LCMS2 1 3 4 4 3 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 8 1 Total_accessions 1 1 1 1 1 1 3 1 3 4 3 3 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 2 1 1 1 1 1 Total_sources no no no no no no no no no no signal confident signal confident signal confident no no signal confident possible signal signal confident signal confident no no no no signal confident no signal confident signal confident no possible signal signal confident signal confident no no no no

Signal 12 0 0 0 2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7 0 0 0 0 0 0 0 0 0 0 0 0 TM Albumin [human,PeptidePartialMutant,25aa]. transaminase) (GPT)(Glutamic--alaninetransaminase). Alanine aminotransferase(EC2.6.1.2)(Glutamic--pyruvic Agouti relatedproteinprecursor. 3, AFG3 atpasefamilygene3-like2;(atpase Afamin precursor;alpha-albumin[Homosapiens]. sapiens]. ADP-ribosyltransferase 1;2[Homo sapiens]. ADP-ribosylation factorbindingproteinGGA3[Homo ear domainofgamma-adaptin). (Gamma-adaptin relatedprotein2)(Vear)(VHSdomainand localized, gammaear-containing,ARF-bindingprotein2) ADP-ribosylation factorbindingproteinGGA2(Golgi- (proam N-terminal20peptide)(PAMP)]. Proadrenomedullin N-20terminalpeptide(proam-N20) ADM precursor[Contains:Adrenomedullin(AM); transcript 1)(apm-1)(Gelatin-bindingprotein). related protein)(ACRP30)(Adiposemostabundantgene Adiponectin precursor(30kdaadipocytecomplement- Adenylyl cyclase-associatedprotein2(CAP2). transphosphorylase). Adenylate kinaseisoenzyme5(EC2.7.4.3)(ATP-AMP Adenylate cyclase3;adenylylcyclase,typeIII;ATP (fragment) Adenovirus E1Aenhancer-bindingproteinE1AF-human homocysteine )(adohcyase). Adenosylhomocysteinase (EC3.3.1.1)(S-adenosyl-L- aminohydrolase). Adenosine deaminase(EC3.5.4.4)(Adenosine Adenomatosis polyposiscoli[Homosapiens]. Adapter-related proteincomplex2alphasubunit chain). (Clathrin assemblyproteincomplex1gamma-1large subunit) (GolgiadaptorHA1/AP1adaptingamma-1 (Gamma-adaptin) (AdaptorproteincomplexAP-1gamma-1 Adapter-related proteincomplex1gammasubunit interacting protein4)(TRIP-4). Activating signalcointegrator1(ASC-1)(Thyroidreceptor Actin, cytoplasmic1(Beta-actin). ). Alpha-2 catenin(Alpha-cateninrelated protein)(AlphaN- receptor; Alpha-1D-adrenergic receptor;adrenergic, alpha-1A-, Alpha-1B-glycoprotein precursor (Alpha-1-B glycoprotein). (Alpha-1-antiproteinase) (PRO0684/PRO2209). Alpha-1-antitrypsin precursor(Alpha-1 proteaseinhibitor) Alpha-1-antichymotrypsin precursor(ACT). (Orosomucoid 1)(OMD1). Alpha-1-acid glycoprotein1precursor(AGP1) L-fucosyltransferase) (Fucosyltransferase6)(FUCT-VI). Alpha-(1,3)-fucosyltransferase (EC2.4.1.65)(Galactoside3- Alpha globin-human alpha-3 Alpha 3typeVIcollagenisoform1precursor;VI, XI, Alpha 1typeXIcollagenisoformApreproprotein; (TNSALP). (EC 3.1.3.1)(AP-TNAP)(Liver/bone/kidneyisozyme) Alkaline phosphatase,tissue-nonspecificisozymeprecursor 3.1.3.1) (PLAP-1). Alkaline phosphatase,placentaltype1precursor(EC specific dehydrogenasetype2)(RALDH(II))(RALDH-2). Aldehyde dehydrogenase1A2(EC1.2.1.3)(Retinaldehyde- Peptide Partial Albumin Herborn{internalfragment}[human,serum,

Description Page 2,H_Plasma_NR Table Four SeparateSources, Andersonetal.Molec.Cell. Proteomics,inpressFeb2004 The HumanPlasma Proteome:ANon-RedundantList DevelopedbyCombinationof P05067 P15157 P17050 P02771 Q99ND2 P04746 P35609 P01023 P02765 P35369 P08697 A49879 NP_001636 P02654 P04114 P06727 P02652 P02647 I37235 P01008 P46013 AAB28159 P49913 P08758 P07355 P27216 Q8WXK1 NP_001139 P01019 P12821 P03950 NP_000035 O15250 P15144 P02760

Accession 1 0 1 1 1 1 1 0 1 0 0 1 0 1 0 0 0 1 1 1 0 1 0 1 1 6 1 1 1 1 0 1 1 0 0 Lit 1 1 0 0 0 0 0 0 1 1 1 0 0 0 0 1 1 1 1 0 1 1 0 0 1 0 1 1 0 1 0 0 0 0 1 2DEMS 1 0 0 2 1 1 1 0 0 2 1 1 2 1 1 0 1 0 0 0 0 0 1 1 0 0 0 0 0 1 0 0 0 0 0 LCMS1 1 1 0 0 2 1 2 0 1 0 0 0 0 0 0 0 0 1 0 0 2 0 0 0 0 0 0 0 0 0 0 1 1 0 0 LCMS2 4 4 5 4 6 1 4 1 1 1 1 1 1 1 1 4 1 1 2 1 1 3 1 6 1 1 1 1 1 5 4 1 1 1 1 Total_accessions 4 1 1 4 4 1 1 3 4 4 4 1 4 1 1 1 1 1 1 1 1 4 1 1 1 1 1 3 1 1 1 1 1 1 1 Total_sources signal confident no signal confident signal confident signal signal signal confident signal confident signal confident signal confident signal confident signal confident signal confident no signal no signal confident signal confident no no no no no signal signal confident signal confident no no signal signal confident signal confident signal confident signal signal no

Signal 0 1 0 0 0 1 0 1 0 0 0 0 0 0 0 0 7 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 TM Angiotensinogen precursor[Contains:AngiotensinI(AngI); (Kininase II)(CD143antigen). (EC 3.4.15.1)(ACE)(DipeptidylcarboxypeptidaseI) Angiotensin-converting ,somaticisoformprecursor 5). Angiogenin precursor(EC3.1.27.-)(Ribonuclease5)(rnase sapiens]. Androgen receptor;dihydrotestosteronereceptor[Homo aminopeptidase) aminopeptidase) (x-pro(proline Aminopeptidase p-like(EC3.4.11.9)(xaa-pro glycoprotein CD13). aminopeptidase) (GP150)(Myeloidplasmamembrane Aminopeptidase N(EC3.4.11.2)(Microsomal inhibitor lightchain(ITI-LC)(Bikunin)(HI-30)]. in charge)(Alpha-1microglycoprotein);Inter-alpha- (Protein HC)(Complex-formingglycoproteinheterogeneous AMBP proteinprecursor[Contains:Alpha-1-microglobulin (Beta-APP) (A-beta)]. nexin-II) (PN-II)(APPI)[Contains:Beta-amyloidprotein Alzheimer's diseaseamyloidA4proteinprecursor( Alpha- precursor(EC3.4.21.59)(Tryptase1). (Alpha-galactosidase B). Alpha-N-acetylgalactosaminidase precursor(EC3.2.1.49) fetoprotein). Alpha-fetoprotein precursor(Alpha-fetoglobulin)(Alpha-1- Alphab-crystallin (Fragment). amylase) (PA). alpha-D-glucan glucanohydrolase)(Pancreaticalpha- Alpha-amylase, pancreaticprecursor(EC3.2.1.1)(1,4- actin crosslinkingprotein). Alpha- 2(Alphaactininskeletalmuscleisoform2)(F- Alpha-2-macroglobulin precursor(Alpha-2-M). globulin) (Ba-alpha-2-glycoprotein)(PRO2743). Alpha-2-HS-glycoprotein precursor(Fetuin-A)(Alpha-2-Z- ADRENOCEPTOR). ALPHA-2C-2 ADRENERGICRECEPTOR(ALPHA-2C-2 (Alpha-2-PI) (Alpha-2-AP). Alpha-2-antiplasmin precursor(Alpha-2-plasmininhibitor) Alpha-2,3-sialyltransferase (EC2.4.99.-)STZ-human Apolipoprotein C-I precursor[Homosapiens]. Apolipoprotein C-Iprecursor(Apo-CI). Apolipoprotein B-48(ApoB-48)]. Apolipoprotein B-100precursor(Apo B-100)[Contains: Apolipoprotein A-IVprecursor(Apo-AIV). Apolipoprotein A-IIprecursor(Apo-AII) (apoa-II). Apolipoprotein A-Iprecursor(Apo-AI). Apo C-IIIfragment-human(fragment) Antithrombin-III precursor(ATIII)(PRO0309). Antigen KI-67. Anti-colorectal carcinomaheavychain[Homosapiens]. 37). antibiotic) (AntimicrobialproteinCAP-18)(hcap-18)(LL- Antibacterial proteinFALL-39precursor(FALL-39peptide (VAC-alpha) (AnchorinCII). (Thromboplastin inhibitor)(Vascularanticoagulant-alpha) (CBP-I) (PlacentalanticoagulantproteinI)(PAP-I)(PP4) Annexin V(LipocortinV)(EndonexinII)(CalphobindinI) protein IV)(PAP-IV). (Chromobindin 8)(P36)(ProteinI)(Placentalanticoagulant Annexin II(LipocortinII)(CalpactinIheavychain) (ISA). Annexin A13(AnnexinXIII)(Annexin,intestine-specific) 15) (Fragment). repeatandSOCSboxcontainingprotein15(ASB- Ankyrin 2isoform1;ankyrin-2,nonerythrocytic;ankyrin-B; Asp[1]-angiotensin II)]. Angiotensin II(AngII);IIIIII)(Des-

Description Page 3,H_Plasma_NR Table Four SeparateSources, Andersonetal.Molec.Cell. Proteomics,inpressFeb2004 The HumanPlasma Proteome:ANon-RedundantList DevelopedbyCombinationof NP_003968 P04424 P78540 A26370 NP_001151 P08519 Q9BWW9 O14791 Q13790 P02649 P05090 P55056 P02656 P02655 P05163 Q09753 A55136 P01884 P02749 P41182 O43491 S31828 Q13075 NP_057336 NP_004312 O75882 S50832 P01160 AAB34738 Q14654 NP_003777 O75027 NP_001080 A59189 AAB46346 NP_006467 P06576 P17174 Q43305 P15848

Accession

0 1 0 1 1 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 1 1 0 0 0 1 0 0 1 0 1 1 1 1 1 1 1 Lit 0 0 0 0 0 0 0 0 0 1 1 1 3 1 0 1 1 0 0 0 0 1 1 1 0 0 0 0 2 0 0 0 0 0 0 0 0 0 0 1 2DEMS 0 1 0 1 1 2 1 0 1 1 1 0 0 0 1 0 0 0 1 0 1 0 1 1 1 1 1 1 1 0 1 1 1 0 0 0 0 1 0 1 LCMS1

0 0 1 1 1 0 0 1 0 1 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 1 1 0 0 0 1 0 0 1 1 1 1 0 1 1 LCMS2 1 1 2 4 1 1 1 1 1 1 2 1 2 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 2 1 4 4 7 4 1 4 4 1 Total_accessions 1 2 1 4 4 4 4 1 4 4 1 1 2 4 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 Total_sources no signal no signal signal confident signal confident signal confident signal confident signal confident signal confident no signal confident no signal confident signal confident no no possible signal no signal no possible signal no signal confident no possible signal no possible signal possible signal no no no possible signal no no signal no no no no

Signal 14 11 5 5 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7 0 0 0 1 0 0 2 2 TM ATP-binding cassette,sub-familyC,member3isoform 7) (ABCtransporter7protein). mitochondrial precursor(ATP-bindingcassettetransporter ATP-binding cassette,sub-familyB,member7, cassette ATP-binding cassette,sub-familyAmember3; ATP-binding cassettetransporter-human(fragment) PAS1 Atpase; strongsimilaritytoperoxisomebiosynthesisprotein subunit g; ATP synthase,H+transporting,mitochondrialF0complex, 3.6.3.14). ATP synthasebetachain,mitochondrialprecursor(EC 1). (Transaminase A)(Glutamateoxaloacetatetransaminase- Aspartate aminotransferase,cytoplasmic(EC2.6.1.1) (Glutamic--aspartic transaminase). (Transaminase A)(Glutamic--OXALOACETICtransaminase) Aspartate aminotransferaseprecursor(EC2.6.1.1) acetylgalactosamine-4-sulfatase) (G4S). Arylsulfatase Bprecursor(EC3.1.6.12)(ASB)(N- hydrocarbon Aryl hydrocarbonreceptorinteractingprotein;aryl (ASAL). Argininosuccinate (EC4.3.2.1)(Arginosuccinase) hepatic arginase)(Kidney-typearginase). Arginase II,mitochondrialprecursor(EC3.5.3.1)(Non- Arginase (EC3.5.3.1),hepatic-human protease Apoptotic proteaseactivatingfactorisoformb;apoptotic Apolipoprotein(a) precursor(EC3.4.21.-)(Apo(a))(Lp(a)). Apolipoprotein L5(ApolipoproteinL-V)(apol-V). (Apolipoprotein L)(apol-I)(Apo-L)(apol). Apolipoprotein L1precursor(ApolipoproteinL-I) Apolipoprotein Fprecursor(Apo-F). Apolipoprotein Eprecursor(Apo-E). Apolipoprotein Dprecursor(Apo-D)(apod). Apolipoprotein C-IVprecursor(Apo-CIV). Apolipoprotein C-IIIprecursor(Apo-CIII). Apolipoprotein C-IIprecursor(Apo-CII). Beta-galactoside-binding lectin(HL14)(Clone2). 1). Beta-defensin 1precursor(BD-1) (hbd-1)(Defensin,beta Beta-coat protein-human(fragment) Beta-2-microglobulin precursor. (APC inhibitor). (B2GPI) (Beta(2)GPI)(Activated protein C-bindingprotein) Beta-2-glycoprotein Iprecursor(Apolipoprotein H)(Apo-H) (LAZ-3 protein)(BCL-5). B-cell lymphoma6protein(BCL-6)(Zincfinger51) (4.1G). Band 4.1-likeprotein2(Generallyexpressed4.1) Band 3aniontransportprotein-human(fragment) apoptosis inhibitoryprotein). Baculoviral IAPrepeat-containingprotein1(Neuronal Baculoviral IAPrepeat-containing6[Homosapiens]. member Axonal transportofsynapticvesicles;,heavychain, Attractin precursor(Mahoganyhomolog)(DPPT-L). Atrophin-1 -human related peptide(CDP)]. peptide) (ANP)(Prepronatriodilatin)[Contains:Cardiodilatin- Atrial natriureticfactorprecursor(ANF)(Atrial sapiens]. ATP-sensitive inwardlyrectifyingK-channelsubunit[Homo member 11)(InwardrectifierK+channelKir6.2)(IKATP). (Potassium channel,inwardlyrectifying,subfamilyJ, ATP-sensitive inwardrectifierpotassiumchannel11 MRP3;

Description Page 4,H_Plasma_NR Table Four SeparateSources, Andersonetal.Molec.Cell. Proteomics,inpressFeb2004 The HumanPlasma Proteome:ANon-RedundantList DevelopedbyCombinationof P21815 NP_004325 NP_001718 P07738 P43251 T00042 NP_003183 O00462 P07686 P06865 P08236 Q13939 P06702 P05109 NP_003647 Q14123 NP_000711 NP_009167 P01258 P10092 P06881 NP_001784 NP_001788 P20851 P04003 I39467 Q9Y6D5 O15382 NP_001694 NP_001693 BAB11885 P55289 P16860 P80723

Accession

0 1 1 0 0 0 0 1 1 1 0 0 1 1 0 0 1 0 0 0 0 1 0 1 0 0 0 0 0 0 0 1 1 1 Lit 0 0 0 0 0 0 1 1 0 0 1 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 1 1 0 1 0 0 0 1 2DEMS 0 0 1 1 0 0 0 0 1 0 0 1 1 1 1 0 0 0 1 1 0 1 1 0 0 1 1 0 0 0 0 0 1 1 LCMS1

0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 1 0 1 0 0 0 0 0 0 0 0 0 0 0 LCMS2 1 2 1 1 1 1 1 1 1 1 1 2 3 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Total_accessions 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 2 3 2 1 1 1 1 1 1 1 1 1 1 1 1 Total_sources no signal confident signal confident no signal confident signal confident signal confident signal no no no no no no no signal confident signal confident signal confident signal confident signal signal confident signal no no possible signal signal confident signal confident no signal signal confident no signal confident signal confident no

Signal 19 0 0 0 0 0 8 6 1 1 0 0 0 0 7 0 0 1 0 0 1 0 0 1 0 0 0 0 0 0 0 0 1 1 TM C4b-binding proteinbetachainprecursor. rich protein)(PRP). C4b-binding proteinalphachainprecursor(c4bp)(Proline- Bullous pemphigoidantigen-human(fragment) (Brefeldin A-inhibitedGEP2). Brefeldin A-inhibitedguaninenucleotide-exchangeprotein2 (PP18). precursor (EC2.6.1.42)(BCAT(m))(Placentalprotein18) Branched-chain aminoacidaminotransferase,mitochondrial Brain-specific angiogenesisinhibitor2 sapiens]. Brain-specific angiogenesisinhibitor1precursor[Homo CMAP in Brain-selective andcloselymappedonthecounteralleleof cadherin 2)(Cadherin,neuraltype,2). Brain-cadherin precursor(BR-cadherin)(Cadherin-12)(N- Brain natriureticpeptideprecursor(BNP). enriched acidicprotein). axonal membraneproteinNAP-22)(Neuronaltissue- Brain acidsolubleprotein1(BASP1protein)(Neuronal sialoprotein) (Integrin-bindingsialoprotein). Bone sialoproteinIIprecursor(BSPII)(Cell-binding sapiens]. Bone marrowstromalcellantigen1precursor[Homo Bombesin-like receptor3[Homosapiens]. 3.1.3.13) (BPG-dependentPGAM). bisphosphoglycerate synthase)(BPGM)(EC5.4.2.1) bisphosphoglycerate mutase,erythrocyte)(2,3- Bisphosphoglycerate mutase(EC5.4.2.4)(2,3- Biotinidase precursor(EC3.5.1.12). BH-protocadherin PCDH7(cloneBH-Pcdh-c)-human Beta- cofactorC[Homosapiens]. (Mannase). Beta-mannosidase precursor(EC3.2.1.25)(Mannanase) acetylhexosaminidase) (HexosaminidaseB). acetyl-beta-glucosaminidase) (Beta-N- Beta-hexosaminidase betachainprecursor(EC3.2.1.52)(N- acetylhexosaminidase) (HexosaminidaseA). (N-acetyl-beta-glucosaminidase) (Beta-N- Beta-hexosaminidase alphachainprecursor(EC3.2.1.52) Beta-glucuronidase precursor(EC3.2.1.31)(Beta-G1). Calicin. calcium-binding proteinA9)(Calprotectin L1Hsubunit). (MRP-14) (P14)(LeukocyteL1complex heavychain)(S100 Calgranulin B(Migrationinhibitory factor-relatedprotein14) (Calprotectin L1Lsubunit). complex lightchain)(S100calcium-binding proteinA8) (MRP-8) (Cysticfibrosisantigen) (CFAG) (P8)(LeukocyteL1 Calgranulin A(Migrationinhibitoryfactor-relatedprotein8) sapiens]. Calcium/calmodulin-dependent proteinkinaseI[Homo 3). phosphodiesterase 1C(EC3.1.4.17)(Cam-PDE1C)(hcam- Calcium/calmodulin-dependent 3',5'-cyclicnucleotide subunit [Homo Calcium channel,voltage-dependent,Ltype,alpha1D calcineurin Calcium bindingproteinP22;SLC9A1protein; (Calcitonin carboxyl-terminalpeptide)(CCP)(PDN-21)]. Calcitonin precursor[Contains:Calcitonin;Katacalcin type CGRP). Calcitonin gene-relatedpeptideIIprecursor(CGRP-II)(Beta- type CGRP). Calcitonin gene-relatedpeptideIprecursor(CGRP-I)(Alpha- cadherin; Cadherin 3,type1preproprotein;P-cadherin;placental cadherin; Cadherin 11,type2isoform1preproprotein;osteoblast

Description Page 5,H_Plasma_NR Table Four SeparateSources, Andersonetal.Molec.Cell. Proteomics,inpressFeb2004 The HumanPlasma Proteome:ANon-RedundantList DevelopedbyCombinationof P15169 P22792 Q96IY4 P15086 P07451 P00918 NP_001729 NP_001866 AAB24773 P27797 1GUA_A P14619 I53799 P00450 T08621 NP_005187 P04637 S29722 XP_045517 NP_001772 O43866 P16070 NP_000064 NP_005185 P25774 P07711 P07339 P07858 P04040 Q92851 NP_036247 P48729 P49747 P06731 Q9JHH6

Accession

0 0 0 1 0 0 1 0 0 0 1 1 0 0 0 1 1 1 0 0 0 0 2 1 1 1 1 0 1 0 0 0 0 0 1 Lit 1 0 0 0 1 1 1 0 1 1 1 0 0 0 0 2 0 1 0 0 0 0 0 0 1 0 0 0 1 1 1 0 1 1 0 2DEMS 0 0 0 1 0 0 0 1 0 1 1 1 2 0 1 0 1 0 0 1 1 0 0 0 0 0 0 0 0 0 0 0 0 1 0 LCMS1

0 0 0 1 0 1 0 0 1 0 0 0 0 1 1 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 1 1 0 LCMS2

1 2 1 4 1 3 1 1 1 1 2 1 1 2 2 2 2 1 1 1 1 1 2 1 1 2 3 1 1 1 1 2 1 1 1 Total_accessions 1 1 1 2 1 1 1 1 1 1 4 1 2 1 1 1 1 2 1 1 2 2 2 2 1 1 1 1 1 1 1 1 2 3 1 Total_sources signal confident no no no no no signal confident no no possible signal signal confident no no no no no possible signal signal confident signal confident signal confident no signal confident signal confident signal confident signal confident no no no no signal confident possible signal signal signal no signal confident

Signal 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8 1 0 1 1 0 TM Sprecursor(EC3.4.22.27). protein) (MEP). Cathepsin Lprecursor(EC3.4.22.15)(Majorexcreted Cathepsin Dprecursor(EC3.4.23.5). secretase). Cathepsin Bprecursor(EC3.4.22.1)(CathepsinB1)(APP Catalase (EC1.11.1.6). (FLICE2). DEATH domainproteininterleukin-1B-convertingenzyme2) protease 4)(ApoptoticMch-4)(FAS-associated Caspase-10 precursor(EC3.4.22.-)(ICE-likeapoptotic FLASH; CASP8 associatedprotein2;FLICEhuge;human (CK1). Casein kinaseI,alphaisoform(EC2.7.1.-)(CKI-alpha) Cartilage oligomericmatrixproteinprecursor(COMP). antigen 100)(CD66eantigen). precursor (Carcinoembryonicantigen)(CEA)(Meconium Carcinoembryonic antigen-relatedcelladhesionmolecule5 inhibitor) (1110032P04Rikprotein) Carboxypeptidase R(-activatablefibrinolysis (Plasma carboxypeptidaseB). carboxypeptidase N)(SCPN)(Anaphylatoxininactivator) (Arginine carboxypeptidase)(Kininase1)(Serum Carboxypeptidase Ncatalyticchainprecursor(EC3.4.17.3) regulatory subunit)(Fragment). Carboxypeptidase N83kdachain(Carboxypeptidase Carboxypeptidase B2 specific protein)(PASP). Carboxypeptidase Bprecursor(EC3.4.17.2)(Pancreas- dehydratase III)(CA-III). Carbonic anhydraseIII(EC4.2.1.1)(Carbonate II) (CA-II)(CarbonicanhydraseC). Carbonic anhydraseII(EC4.2.1.1)(Carbonatedehydratase sapiens]. Carbonic anhydraseI;carbonicdehydratase[Homo sapiens]. Carbamoyl-phosphate synthetase1,mitochondrial[Homo suppressing and Cancer-associated SCM-recognitionimmunedefense- (erp60). Calreticulin precursor(CRP55)(Calregulin)(HACBP) Domain OfHuman C-Raf1,Residues51-131 (e30d,k31e) ComplexedWithGppnhp AndTheRas-Binding- Chain A,HumanRap1a,Residues 1-167,DoubleMutant 2.7.1.37) (cgk1beta)(cgki-beta). Cgmp-dependent proteinkinase1, betaisozyme(EC CG1 protein-human Ceruloplasmin precursor(EC1.16.3.1) (Ferroxidase). Centrosome associatedproteinCEP250-human centromere Centromere proteinF(350/400kd,mitosin);mitosin; (Phosphoprotein p53)(AntigenNY-CO-13). Cellular tumorantigenp53(Tumorsuppressorp53) Cellular adhesionregulatoryprotein-human cytidylyltransferase) 2 CDP-diacylglycerol synthase(phosphatidate sapiens]. CD69 antigen(p60,earlyT-cellactivationantigen)[Homo associated peptide). CD5 antigen-likeprecursor(SP-alpha)(CT-2)(igm- proteoglycan) (Epican)(cdw44). antigen) (Hyaluronatereceptor)(Heparansulfate (GP90 lymphocytehoming/adhesionreceptor)(Hermes (HUTCH-I) (Extracellularmatrixreceptor-III)(ECMR-III) CD44 antigenprecursor(PhagocyticglycoproteinI)(PGP-1) gamma chain CD3G gammaprecursor;T-cellsurfaceglycoproteinCD3 dependent CCAAT/enhancer bindingproteinbeta;interleukin6-

Description Page 6,H_Plasma_NR Table Four SeparateSources, Andersonetal.Molec.Cell. Proteomics,inpressFeb2004 The HumanPlasma Proteome:ANon-RedundantList DevelopedbyCombinationof P06276 NP_065574 P11597 NP_004061 NP_004379 P36222 NP_001328 NP_006420 NP_006421 1CGI_I P02458 P02452 NP_005498 P48444 P05160 P00488 P00748 P03951 P00742 P00451 P08709 P12259 P00740 NP_004077 P10909 Q10570 P26441 O95239 P10645 NP_001263 NP_001262 P01233

Accession

0 1 0 0 1 1 1 1 1 1 1 1 1 0 1 0 0 0 1 0 0 1 1 0 1 0 0 1 0 0 0 0 Lit 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 1 0 1 0 0 0 1 0 1 0 1 1 0 2DEMS 1 1 0 1 0 1 0 0 0 0 1 1 0 1 0 0 1 0 1 0 1 1 1 0 0 0 1 0 0 0 0 0 LCMS1

1 0 1 0 0 1 1 0 0 0 0 1 1 0 1 0 0 0 0 0 1 0 0 1 0 1 0 0 0 1 1 1 LCMS2 1 1 1 3 3 4 1 2 2 1 3 3 1 4 1 1 1 1 1 1 1 2 1 1 2 1 1 1 1 2 1 1 Total_accessions 2 1 1 1 1 2 1 1 1 1 3 3 4 1 2 2 1 3 3 1 4 1 1 1 1 1 1 1 2 1 1 1 Total_sources no signal confident signal confident possible signal no no no signal confident signal confident no possible signal signal confident no signal confident signal signal confident signal signal confident signal confident signal signal confident signal confident no no no signal confident no no signal confident signal confident no signal confident

Signal 10 0 0 0 0 0 0 0 0 0 1 0 0 0 0 7 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 TM factorChomolog,cochlinprecursor; NA2) (ApolipoproteinJ)(Apo-J)(TRPM-2). 40,40) (Complementcytolysisinhibitor)(CLI)(NA1and Clusterin precursor(Complement-associatedproteinSP- subunit (CPSF160kdasubunit). Cleavage andpolyadenylationspecificityfactor,160kda Ciliary neurotrophicfactor(CNTF). -associated kinesinKIF4A(Chromokinesin). 11; GV-19;GR-44;ER-37]. 92; ES-43;Pancreastatin;SS-18;WA-8;WE-14;LF-19;AL- protein I)(SP-I)[Contains:VasostatinI;II;EA- Chromogranin Aprecursor(CGA)(Pituitarysecretory finger Chromodomain helicaseDNAbindingprotein3;Mi-2a;zinc- sapiens]. Chromodomain helicaseDNAbindingprotein2[Homo gonadotrophin betasubunit)(CG-beta). Choriogonadotropin betachainprecursor(Chorionic esterase) (Pseudocholinesterase). acylhydrolase) (CholineesteraseII)(Butyrylcholine Cholinesterase precursor(EC3.1.1.8)(Acylcholine Choline acetyltransferaseisoform2;acetylcoa:choline protein I). Cholesteryl estertransferproteinprecursor(Lipid [Homo Chloride channelKa;channel,kidney,A;hclc-Ka Chitobiase, di-N-acetyl-[Homosapiens]. 39) (GP-39)(39kdasynovialprotein)(YKL-40). Chitinase-3 likeprotein1precursor(Cartilageglycoprotein- receptor 13; Chemokine (C-X3-Cmotif)receptor1;Gprotein-coupled containing Chaperonin containingTCP1,subunit7(eta);chaperonin Chaperonin containingTCP1,subunit4(delta);chaperonin Pancreatic SecretoryTrypsinInhibitorVariant3 Chain I,Alpha-ChymotrypsinogenComplexWithHuman Chondrocalcin]. Collagen alpha1(II)chainprecursor [Contains: Collagen alpha1(I)chainprecursor. Cofilin 1(non-muscle)[Homosapiens]. (Archain). Coatomer deltasubunit(Delta-coat protein)(Delta-COP) chain) (FibrinstabilizingfactorB subunit). gamma-glutamyltransferase Bchain)(Transglutaminase Coagulation factorXIIIBchainprecursor(Protein-glutamine (Transglutaminase Achain). (Protein-glutamine gamma-glutamyltransferaseAchain) Coagulation factorXIIIAchainprecursor(EC2.3.2.13) factor) (HAF). Coagulation factorXIIprecursor(EC3.4.21.38)(Hageman thromboplastin antecedent)(PTA)(FXI). Coagulation factorXIprecursor(EC3.4.21.27)(Plasma factor). Coagulation factorXprecursor(EC3.4.21.6)(Stuart (Antihemophilic factor)(AHF). Coagulation factorVIIIprecursor(Procoagulantcomponent) prothrombin conversionaccelerator)(Eptacogalfa). Coagulation factorVIIprecursor(EC3.4.21.21)(Serum ). Coagulation factorVprecursor(ActivatedproteinC factor). Coagulation factorIXprecursor(EC3.4.21.22)(Christmas coagulation factor

Description Page 7,H_Plasma_NR Table Four SeparateSources, Andersonetal.Molec.Cell. Proteomics,inpressFeb2004 The HumanPlasma Proteome:ANon-RedundantList DevelopedbyCombinationof P01024 P06681 P09871 P00736 P02747 P02746 P02745 P45452 CGHU6B P08123 B40983 Q03692 P27658 P20908 P02462 P02461 P08185 P06850 NP_009005 P22528 Q04656 Q12860 P48740 P20023 P05156 Q9BXR6 P36980 A40455 P08603 P00746 P00751 P08174 P02748 P07360 P07358 P07357 P10643 P13671 S27041 P01031 1006226A P01028

Accession

1 1 0 0 0 0 1 1 1 1 0 0 1 1 1 1 1 1 1 1 1 1 0 1 0 1 1 1 1 1 1 1 1 1 0 0 0 0 0 0 1 1 Lit 1 2 1 1 1 1 1 0 0 0 0 0 2 0 1 1 0 0 0 1 0 0 0 1 0 1 0 3 0 1 1 1 0 1 0 1 1 1 1 1 1 0 2DEMS 0 0 0 1 0 1 0 0 0 1 0 1 0 0 0 1 1 0 0 1 0 0 1 2 0 1 0 1 1 1 1 1 1 1 1 0 2 1 1 1 1 0 LCMS1

0 0 1 1 0 0 0 0 0 0 0 0 0 0 1 0 1 0 0 1 0 1 0 0 0 1 1 0 1 1 0 0 0 0 0 0 0 0 0 1 1 0 LCMS2 1 1 1 2 1 2 1 5 1 1 2 4 1 4 1 4 3 3 4 3 4 1 3 2 5 4 3 4 4 1 1 1 1 1 2 1 1 1 1 3 1 3 Total_accessions 1 1 1 1 1 1 1 1 1 3 1 1 1 1 2 1 2 1 3 1 1 2 3 1 4 1 4 3 3 4 3 4 1 3 1 4 4 3 4 4 1 3 Total_sources signal confident signal signal confident signal confident signal confident no signal confident signal signal signal signal confident signal signal confident no no no signal confident signal confident signal confident signal signal confident signal confident no signal confident signal confident signal signal confident signal confident signal confident signal confident signal confident signal confident signal no signal confident no signal signal confident signal confident signal confident signal confident signal confident

Signal 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7 0 0 1 0 0 0 0 0 TM convertase activator)(ProperdinfactorD)(Adipsin). Complement factorDprecursor(EC3.4.21.46)(C3 glycoprotein) (GBG)(PBF2). convertase) (ProperdinfactorB)(Glycine-richbeta Complement factorBprecursor(EC3.4.21.47)(C3/C5 antigen). Complement decay-acceleratingfactorprecursor(CD55 Complement componentC9precursor. Complement componentC8gammachainprecursor. Complement componentC8betachainprecursor. Complement componentC8alphachainprecursor. Complement componentC7precursor. Complement componentC6precursor. Complement componentC3b-human(fragments) Complement C5precursor[Contains:C5aanaphylatoxin]. Complement c4d. Complement C4precursor[Contains:C4Aanaphylatoxin]. Complement C3precursor[Contains:C3aanaphylatoxin]. convertase). Complement C2precursor(EC3.4.21.43)(C3/C5 esterase). Complement C1scomponentprecursor(EC3.4.21.42)(C1 Complement C1rcomponentprecursor Complement C1qsubcomponent,Cchainprecursor. Complement C1qsubcomponent,Bchainprecursor. Complement C1qsubcomponent,Achainprecursor. metalloproteinase-13) (MMP-13). Collagenase 3precursor(EC3.4.24.-)(Matrix Collagen alpha6(IV)chainprecursor-human Collagen alpha2(I)chainprecursor. Collagen alpha1(XIII)chainprecursor-human Collagen alpha1(X)chainprecursor. collagen). Collagen alpha1(VIII)chainprecursor(Endothelial Collagen alpha1(V)chainprecursor. Collagen alpha1(IV)chainprecursor. Collagen alpha1(III)chainprecursor. (Transcortin). Corticosteroid-binding globulinprecursor (CBG) (CRF) (Corticotropinreleasinghormone). Corticoliberin precursor(Corticotropin-releasing factor) 1A; Coronin, actinbindingprotein,1A; coronin,actin-binding, pancornulin). Cornifin B(Smallproline-richprotein IB)(SPR-IB)(14.9kda (Menkes disease-associatedprotein). Copper-transporting atpase1(EC3.6.3.4)(Copperpump1) Contactin precursor(Glycoproteingp135). (MASP-1). (Mannose-binding proteinassociatedserineprotease) p100) (rarf)(Mannan-bindinglectinserineprotease1) precursor (EC3.4.21.-)(Ra-reactivefactorserineprotease Complement-activating componentofRa-reactivefactor (CD21 antigen). C3d receptor)(Epstein-Barrvirus(EBV Complement receptortype2precursor(Cr2)(Complement inactivator). Complement factorIprecursor(EC3.4.21.45)(C3B/C4B Complement factorH-relatedprotein5precursor(FHR-5). (H factor-likeprotein2)3)(DDESK59). Complement factorH-relatedprotein2precursor(FHR-2) precursor -human(fragment) Complement factorH-relatedprotein(cloneH36-1) Complement factorHprecursor(H1).

Description Page 8,H_Plasma_NR Table Four SeparateSources, Andersonetal.Molec.Cell. Proteomics,inpressFeb2004 The HumanPlasma Proteome:ANon-RedundantList DevelopedbyCombinationof P38936 NP_004692 Q13618 NP_001072 P23582 O95104 NP_036208 JC2386 P06732 P12277 P02741 P24387 P01189 P27487 Q99518 NP_001338 NP_003639 NP_001379 P15924 NP_001934 P17661 O43323 P81605 NP_004931 NP_004389 Q99856 S71758 1DSN P49902 NP_000093 P08574 P32320 P13569 P54108 Q9Y600 P01034 T09483 NP_004187

Accession

1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 1 0 1 0 1 0 0 1 0 0 0 1 0 0 0 1 1 1 1 1 Lit 1 0 0 0 0 0 1 0 0 0 0 0 1 0 1 0 0 0 1 0 0 0 0 0 1 0 1 0 0 1 0 1 0 0 0 0 0 0 2DEMS 0 1 0 0 0 0 0 0 0 0 0 0 1 1 1 1 0 1 0 1 1 0 0 2 1 1 1 0 1 0 0 0 1 0 0 1 0 0 LCMS1

0 0 1 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 1 0 0 0 1 0 0 1 1 0 0 0 0 0 LCMS2

1 1 1 1 1 1 1 1 1 1 1 1 1 1 3 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 2 1 1 Total_accessions 1 1 1 1 2 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 2 1 1 1 1 1 1 1 1 1 1 1 1 1 Total_sources signal confident no possible signal no no no signal confident possible signal signal signal confident possible signal no no no no signal confident no signal confident signal confident no no possible signal no no no signal signal no no signal confident no signal confident signal no no no no signal confident

Signal 11 12 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 1 0 0 0 0 0 0 0 0 TM Cytosolic purine5'-nucleotidase(EC3.1.3.5). monooxygenase; Cytochrome P450,family17;steroid17-alpha- (Cytochrome c-1). Cytochrome c1,hemeprotein,mitochondrialprecursor Cytidine deaminase(EC3.5.4.5)(Cytidineaminohydrolase). (CFTR) (camp-dependentchloridechannel). Cystic fibrosistransmembraneconductanceregulator (SGP28 protein). Cysteine-rich secretoryprotein-3precursor(CRISP-3) decarboxylase). (Sulfinoalanine decarboxylase)(Cysteine-sulfinate Cysteine sulfinicaciddecarboxylase(EC4.1.1.29) (Gamma-trace) (Post-gamma-globulin). Cystatin Cprecursor(Neuroendocrinebasicpolypeptide) Cys-rich proteinRAMP-human kinase Cyclin-dependent kinase-like1;serine/threonineprotein (MDA-6). protein 1)(Melanomadifferentiationassociated6) Cyclin-dependent kinaseinhibitor1(p21)(CDK-interacting Cyclin B2[Homosapiens]. Cullin homolog3(CUL-3). Cubilin; intrinsicfactor-cobalaminreceptor;factor CNP-29; CNP-53]. C-type natriureticpeptideprecursor[Contains:CNP-22; CTD-binding SR-likeproteinRA4(Fragment). Crumbs homolog1[Homosapiens]. Creatine transporterBS2M-human Creatine kinase,Mchain(EC2.7.3.2)(M-CK). Creatine kinase,Bchain(EC2.7.3.2)(B-CK). C-reactive proteinprecursor. hormone-binding protein)(CRH-BP). (CRF-binding protein)(CRF-BP)(Corticotropin-releasing Corticotropin-releasing factorbindingproteinprecursor Corticotropin-lipotropin precursor(Pro-opiomelanocortin) complexing protein-2) (ADABP). activation antigenCD26)(TP103) (Adenosinedeaminase Dipeptidyl peptidaseIV(EC3.4.14.5) (DPPIV)(T-cell (FMO 2)(Dimethylanilineoxidase 2)(FMO1B1). 1.14.13.8) (Pulmonaryflavin-containing monooxygenase2) Dimethylaniline monooxygenase [N-oxide forming]2(EC Diacylglycerol kinase,theta(110kd); Diacylglycerolkinase kinase; Diacylglycerol kinase,delta130kdaisoform1;diglyceride sapiens]. Developmentally regulatedGTPbindingprotein2[Homo antigen). (DP)(250/210kdaparaneoplasticpemphigus sapiens]. Desmoglein 2preproprotein;HDGC,included[Homo . Desert hedgehogproteinprecursor(DHH)(HHG-3). promoting peptide;DCD-1]. Dermcidin precursor(Preproteolysin)[Contains:Survival- DEAD/H (Asp-Glu-Ala-Asp/His)boxpolypeptide7; box-10 (RNA DEAD/H (Asp-Glu-Ala-Asp/His)boxpolypeptide10; transcription) (Bright). Dead ringerlike-1protein(B-cellregulatorofigh DEAD boxproteinmrdb,Myc-regulated-human D60S N-TERMINALLOBEHUMANLACTOFERRIN

Description Page 9,H_Plasma_NR Table Four SeparateSources, Andersonetal.Molec.Cell. Proteomics,inpressFeb2004 The HumanPlasma Proteome:ANon-RedundantList DevelopedbyCombinationof P51530 ISHUT1 O75771 P20585 Q16531 NP_056418 NP_056459 CAC12920 AAB34527 P53634 P05305 JC2521 Q9UNN8 P14625 NP_079032 P49411 P15502 Q9H223 O95967 NP_004096 O14682 A40492 NP_001955 P11532 NP_004384 O43237 Q14203 O43781 NP_004643 NP_055565 P55265 O60216 P09172 Q01831 A29160 A40448

Accession

1 0 1 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 1 1 0 0 0 0 0 0 0 0 0 0 0 0 0 Lit 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 1 1 0 0 1 1 0 0 0 0 0 0 1 1 1 0 0 1 0 1 2DEMS 0 0 1 0 1 0 0 1 0 0 0 1 1 0 0 0 0 1 0 1 1 0 0 0 1 0 0 0 0 0 1 1 1 0 1 0 LCMS1

0 1 0 0 0 0 0 0 0 1 0 0 1 0 0 0 0 0 0 1 0 0 0 1 0 0 0 1 0 1 1 1 0 1 0 0 LCMS2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 Total_accessions 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 2 Total_sources no no no no no signal confident signal confident possible signal signal confident signal confident signal confident possible signal signal no signal confident signal confident no no no no signal confident no no no no no no no signal confident no no no possible signal no possible signal possible signal

Signal 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 0 0 0 7 0 0 0 0 0 0 0 1 0 TM 1(150kdadynein-associatedpolypeptide)(DP- (EC 2.7.1.-). Dual-specificity tyrosine-phosphorylationregulatedkinase3 fat Drosophila fatfacetsrelated,X-linkedisoform1; Drosophila discslarge-1tumorsupressor-like;hepatoma protein) (P136)(K88DSRBP). 3.5.4.-) (DRADA)(136kdadouble-strandedRNAbinding Double-stranded RNA-specificadenosinedeaminase(EC (Nuclear matrixprotein1)(NXP-1). Double-strand-break repairproteinrad21homolog(hhr21) (Dopamine beta-hydroxylase)(DBH). Dopamine beta-monooxygenaseprecursor(EC1.14.17.1) pigmentosum groupCcomplementingprotein)(P125). DNA-repair proteincomplementingXP-Ccells(Xeroderma Dnak-type molecularchaperoneHSPA1L-human DNA-binding proteinCDR-62-human(fragment) (Fragment). DNA2-like homolog(DNAreplicationhelicase-likehomolog) DNA topoisomerase(EC5.99.1.2)-human DNA repairproteinRAD51homolog4(R51H3)(TRAD). protein) (DUP)(Mismatchrepairprotein1)(MRP1). DNA mismatchrepairproteinMsh3(Divergentupstream associated protein1)(XAP-1). pigmentosum groupEcomplementingprotein)(xpce)(X- DNA-binding protein1)(UV-DDB(Xeroderma binding protein1)(DDBp127subunit)(ddba)(UV-damaged DNA damagebindingprotein1(Damage-specific DKFZP586M1019 protein[Homosapiens]. DKFZP434B103 protein[Homosapiens]. human Dj492j12.1 (novelproteinsimilartozincfinger fragment 1} Dipeptidylpeptidase IV,DPPIV=rscd26homolog{internal (DPPI) (CathepsinC)J)(Dipeptidyltransferase). Dipeptidyl-peptidase Iprecursor(EC3.4.14.1)(DPP-I) Endothelin-1 precursor (ET-1). veinendothelial cellform-human Endothelin convertingenzyme(EC 3.4.24.-)1,umbilical receptor) (CD201antigen). protein Creceptor)(Activated Creceptor)(APC Endothelial proteinCreceptorprecursor (Endothelialcell (GRP94) (gp96homolog)(Tumor rejectionantigen1). Endoplasmin precursor(94kdaglucose-regulated protein) EMILIN-like proteinendoglyx-1[Homosapiens]. Elongation factorTu,mitochondrialprecursor(P43). Elastin precursor(Tropoelastin). protein 10/11). protein FKSG7)(Hepatocellularcarcinoma-associated EH-domain containingprotein4(EHdomain-containing precursor (Fibulin-4)(FIBL-4)(UPH1protein). EGF-containing fibulin-likeextracellularmatrixprotein2 isoform EGF-containing fibulin-likeextracellularmatrixprotein1 protein 10)(NuclearmatrixNRP/B). Ectoderm-neural cortex-1protein(ENC-1)(P53-induced Early growthresponse2protein(EGR2)-human Early growthresponse1;G0S30[Homosapiens]. . 1precursor;156DAG;Dystrophin-associated 2). lightintermediatechain2,cytosolic(LIC53/55)(LIC- 150) (DAP-150)(p150-glued)(p135).

Description Page 10,H_Plasma_NR Table Four SeparateSources, Andersonetal.Molec.Cell. Proteomics,inpressFeb2004 The HumanPlasma Proteome:ANon-RedundantList DevelopedbyCombinationof P49257 P12830 P42566 P00533 NP_004438 NP_004431 P13727 P12724 NP_004447 C32891 NP_001447 O75636 Q15485 O00602 P23142 P02751 Q92912 NP_004458 P02679 P02675 P02671 AAB47117 P02792 P02794 Q9UKT8 P07148 P05413 AAB35516 P37268 NP_003893 Q8IZF9 NP_004416 NP_055839 NP_003743 P16581 P19235

Accession

0 0 1 1 1 1 1 0 0 1 1 1 0 1 1 0 1 1 0 0 0 1 0 0 0 1 1 1 1 0 0 0 0 1 1 0 Lit 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 1 1 0 0 0 1 0 0 0 0 0 0 0 0 1 0 0 1 0 2DEMS 1 1 1 0 0 0 1 0 0 0 0 0 3 1 1 0 0 1 1 0 0 0 0 0 1 0 1 0 1 0 1 0 0 0 0 0 LCMS1

0 1 0 0 0 1 1 0 0 0 1 1 0 0 0 1 0 0 0 0 0 0 1 1 0 0 0 0 0 1 0 0 0 0 0 1 LCMS2 1 2 1 1 3 6 1 1 1 3 3 1 1 1 1 1 1 1 1 1 1 3 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Total_accessions 1 1 1 1 1 1 1 2 1 1 3 4 1 1 1 3 3 1 1 1 1 1 1 1 1 1 1 3 1 1 1 1 1 1 1 1 Total_sources signal confident no signal confident signal confident signal confident no no no signal confident signal confident signal confident signal confident signal confident no signal confident signal confident signal signal confident no no no no no no no no no signal confident signal confident no no signal signal signal signal confident possible signal

Signal 0 0 0 0 0 0 0 0 1 1 1 1 0 2 0 1 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 TM inhibitor) (MDGI). acid-binding protein)(M-FABP)(Mammary-derivedgrowth Fatty acid-bindingprotein,heart(H-FABP)(Musclefatty Fatty acidsynthase;FAS[Homosapiens]. farnesyltransferase). (Squalene synthetase)(SQS)(SS)(FPP:FPP Farnesyl-diphosphate farnesyltransferase(EC2.5.1.21) element binding Far upstreamelement-bindingprotein;far Extracellular matrixproteinperiostin-bm Extracellular matrixprotein1isoformprecursor;secretory Exportin 7;RANbindingprotein16[Homosapiens]. Eukaryotic translationinitiationfactor3,subunit8,110kda; molecule 2)(LECAM2)(CD62E). molecule 1)(ELAM-1)(Leukocyte-endothelialcelladhesion E-selectin precursor(Endothelialleukocyteadhesion Erythropoietin receptorprecursor(EPO-R). (Gp58) (IntracellularmannosespecificlectinMR60). compartment 53kdaprotein)(Lectin,mannose-binding1) ERGIC-53 proteinprecursor(ER-Golgiintermediate (Cadherin-1) (CAM120/80). Epithelial-cadherin precursor(E-cadherin)(Uvomorulin) Eps15) (AF-1Pprotein). Epidermal growthfactorreceptorsubstrate15(Protein (Receptor protein-tyrosinekinaseerbb-1). Epidermal growthfactorreceptorprecursor(EC2.7.1.112) [Homo Epidermal growthfactorreceptorpathwaysubstrate8 Epha7; Hek11;ephrinreceptorepha7[Homosapiens]. (Proteoglycan 2,bonemarrow)(BMPG). (EMBP) (Pregnancyassociatedmajorbasicprotein) Eosinophil granulemajorbasicproteinprecursor(MBP) (Ribonuclease 3)(rnase3). Eosinophil cationicproteinprecursor(EC3.1.27.-)(ECP) sapiens]. Enhancer ofzeste2isoforma;enhancer[Homo Finger protein9,placental-human alpha 1(actin-bindingprotein-280); filamin1;A, P35) (Hakataantigen). protein 3)(Collagen/fibrinogendomain-containing lectin3 Ficolin 3precursor(Collagen/fibrinogen domain-containing 37) (Hucolin)(L-Ficolin). protein 2)(Ficolin-B)(FicolinB)(Serum lectinP35)(EBP- Ficolin 2precursor(Collagen/fibrinogendomain-containing protein 1)(Ficolin-A)(FicolinA)(M-Ficolin). Ficolin 1precursor(Collagen/fibrinogendomain-containing Fibulin-1 precursor. Fibronectin precursor(FN)(Cold-insolubleglobulin)(CIG). factor). factor homologous1)(FHF-1)(Myocyte-activating Fibroblast growthfactor-12(FGF-12)(Fibroblast Fibrinogen-like 1precursor;hepassocin;hepatocyte-derived Fibrinogen gammachainprecursor(PRO2061). B]. Fibrinogen betachainprecursor[Contains:Fibrinopeptide Fibrinopeptide A]. Fibrinogen alpha/alpha-Echainprecursor[Contains: Fibrinogen Aalphachain[Homosapiens]. Ferritin lightchain(FerritinLsubunit). Ferritin heavychain(FerritinHsubunit). F-box/WD-repeat protein2. Fatty acid-bindingprotein,liver(L-FABP).

Description Page 11,H_Plasma_NR Table Four SeparateSources, Andersonetal.Molec.Cell. Proteomics,inpressFeb2004 The HumanPlasma Proteome:ANon-RedundantList DevelopedbyCombinationof NP_002022 NP_002560 P16930 P04075 NP_005429 Q99853 P01225 O95633 P23945 Q13451 JC4131 P14136 I52300 Q9UBU3 NP_001505 P06396 O95479 P16383 P01350 P19440 Q92820 JE0356 XP_041409 P09104 P11844 NP_005558 A36071 A54898 P22466 NP_000146 NP_002031 NP_055591 NP_054749 B55733 NP_004215 NP_005270

Accession

0 1 0 1 0 1 0 0 1 1 0 0 0 1 1 0 0 0 1 0 0 0 0 0 0 0 0 0 0 1 0 0 1 1 0 0 Lit 0 0 0 0 0 0 0 1 0 0 0 1 0 0 1 0 1 0 0 0 1 1 1 0 0 1 0 0 1 0 0 0 0 0 0 0 2DEMS 0 0 1 0 0 0 0 0 0 1 0 0 1 0 0 0 0 0 1 0 0 0 1 1 1 0 0 1 1 0 0 0 1 0 0 0 LCMS1

1 0 0 0 1 1 0 0 0 0 0 0 1 0 0 0 0 0 0 1 0 0 1 1 1 0 1 1 0 0 1 0 0 0 1 0 LCMS2 2 1 1 1 4 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 Total_accessions 1 1 1 2 1 1 1 2 1 1 1 4 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Total_sources no no no signal possible signal signal confident no no no no signal confident no signal confident signal confident possible signal signal confident signal confident signal confident signal confident signal confident no no signal confident no signal confident signal confident no no no no no no no no signal confident no

Signal 0 0 0 1 0 0 0 0 0 7 7 7 0 1 0 0 0 0 0 0 7 0 0 0 1 0 0 0 0 0 0 2 0 7 4 0 TM Gamma crystallinA(Gamma5). protein; Galectin 3bindingprotein;L3antigen;Mac-2-binding Galectin 3(version1)-human human Gal-beta1,3galnac alpha-2,3-sialyltransferase(EC2.4.99.-)- associated peptide(GMAP)]. Galanin precursor[Contains:Galanin;message- sapiens]. Galactose-1-phosphate uridylyltransferaseisoform1[Homo (60kd); GA bindingproteintranscriptionfactor,alphasubunit ARF G protein-coupledreceptorkinase-interactor2isoform3; protein [Homo G protein-coupledreceptorkinase-interactor1;GIT1 G protein-coupledreceptorGPR2-human(fragment) G protein-coupledreceptor50[Homosapiens]. G protein-coupledreceptor1[Homosapiens]. Fyn-related kinase[Homosapiens]. type 3; preproprotein;proproteinconvertasesubtilisin/kexin hydrolase) (Beta-diketonase)(FAA). Fumarylacetoacetase (EC3.7.1.2)(Fumarylacetoacetate type aldolase)(LungcancerantigenNY-LU-1). Fructose-bisphosphate aldolaseA(EC4.1.2.13)(Muscle- FOS-like antigen1;antigen-1[Homosapiens]. Forkhead boxproteinB1(TranscriptionfactorFKH-5). hormone betasubunit)(FSH-beta)(FSH-B). Follitropin betachainprecursor(Follicle-stimulating (Follistatin-related geneprotein). Follistatin-related protein3precursor(Follistatin-like3) (Follitropin receptor). Follicle stimulatinghormonereceptorprecursor(FSH-R) trans ) FK506-binding protein5(EC5.2.1.8)(Peptidyl-prolylcis- Glioma pathogenesis-relatedprotein -human Glial fibrillaryacidicprotein,astrocyte (GFAP). Giantin -human protein). hormone releasingpeptide)(Motilin-related peptide)(M46 Ghrelin precursor(Growthhormone secretagogue)(Growth transcription General transcriptionfactorIIB;RNApolymeraseII (ADF) (Brevin)(AGEL). precursor,plasma(Actin-depolymerizingfactor) (EC 3.1.1.31)(6PGL)]. 6-phosphate dehydrogenase);6-phosphogluconolactonase [Includes: Glucose1-dehydrogenase(EC1.1.1.47)(Hexose- GDH/6PGL endoplasmicbifunctionalproteinprecursor factor 9)(TCF-9). GC-rich sequenceDNA-bindingfactor(GCF)(Transcription Gastrin precursor. (Gamma-glutamyltransferase 1)(CD224antigen). Gamma-glutamyltranspeptidase 1precursor(EC2.3.2.2) (Gamma-Glu-X carboxypeptidase)(Conjugase)(GH). Gamma-glutamyl hydrolaseprecursor(EC3.4.19.9) Gamma-aminobutyric acidreceptorBprecursor-human [Homo Gamma-aminobutyric acid(GABA)receptor,thetaprecursor hydro-lyase) (Neuralenolase)(NSE)(Enolase2). Gamma enolase(EC4.2.1.11)(2-phospho-D-glycerate

Description Page 12,H_Plasma_NR Table Four SeparateSources, Andersonetal.Molec.Cell. Proteomics,inpressFeb2004 The HumanPlasma Proteome:ANon-RedundantList DevelopedbyCombinationof NP_055106 P48637 P21266 P07203 A47531 Q96KN2 Q04609 P11413 NP_002047 NP_004482 NP_000151 P01275 NP_001513 NP_002044 P29992 P50148 O60262 NP_004116 O14793 P43026 P10912 JW0057 P04141 P09919 NP_002078 AAB34872 Q13439 Q92896 NP_004475 NP_001494 P01215 P35573 P09466 NP_004474

Accession

0 0 0 0 0 0 1 0 1 0 1 1 0 0 0 0 0 0 1 0 1 0 0 0 0 1 0 0 1 1 0 0 0 1 Lit 0 0 0 1 1 0 1 1 1 0 0 0 0 0 0 0 1 1 1 0 0 0 0 1 0 0 0 0 1 0 0 1 0 1 2DEMS 0 1 0 1 0 0 1 1 0 1 1 0 0 0 1 0 1 0 1 0 0 0 5 0 0 0 1 0 0 0 1 0 0 0 LCMS1

0 0 0 0 0 0 0 0 0 0 0 0 1 2 0 1 1 0 0 0 0 0 1 0 0 0 0 0 0 0 1 0 0 0 LCMS2 1 1 1 1 1 1 1 1 2 1 1 1 7 1 1 1 2 1 1 1 1 1 1 1 1 2 1 3 1 1 1 1 1 1 Total_accessions 1 2 1 3 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 2 1 1 1 2 1 1 1 1 1 1 1 1 Total_sources possible signal possible signal signal confident possible signal no no no signal confident signal confident signal no no no no no signal confident signal signal confident no signal confident signal signal confident no no signal confident signal confident signal signal confident no signal confident signal possible signal no no

Signal 1 0 0 0 0 0 0 0 0 0 0 1 0 1 0 0 0 7 0 2 0 0 0 0 0 0 0 1 0 0 0 0 0 0 TM fibroblast growthfactorreceptor)(CFR-1). MG-160) (E-selectinligand1)(ESL-1)(Cysteine-rich Golgi apparatusprotein1precursor(Golgisialoglycoprotein Glypican 3[Homosapiens]. isoform 1 Glycosylphosphatidylinositol specificphospholipaseD1 Glycoprotein hormonesalphachainprecursor glucosidase)]. (EC 3.2.1.33)(Amylo-1,6-glucosidase)(Dextrin6-alpha-D- 1,4-1,4-glucantransferase); Amylo-alpha-1,6-glucosidase [Includes: 4-alpha-glucanotransferase(EC2.4.1.25)(Oligo- Glycogen debranchingenzyme(Glycogendebrancher) (Progestagen-associated endometrialprotein). protein 14)(Progesterone-associatedendometrialprotein) endometrial alpha-2globulin)(PEG)(PAEG)(Placental Glycodelin precursor(GD)(Pregnancy-associated [Homo Glycine cleavagesystemproteinH(aminomethylcarrier) ketobutyrate-coa Glycine C-acetyltransferaseprecursor;2-amino-3- (GSH synthetase)(GSH-S). Glutathione synthetase(EC6.3.2.3)(Glutathionesynthase) (GST class-mu3)(hgstm3-3). Glutathione S-transferaseMu3(EC2.5.1.18)(GSTM3-3) glutathione peroxidase). Glutathione peroxidase(EC1.11.1.9)(gshpx-1)(Cellular Glutamyl aminopeptidase(EC3.4.11.7)-human Glutamate carboxypeptidase-likeprotein2precursor. Glutamate carboxypeptidaseII(EC3.4.17.21) (G6PD). Glucose-6-phosphate 1-dehydrogenase(EC1.1.1.49) glutamine: Glucosamine-fructose-6-phosphate aminotransferase; [Homo Glucocorticoid receptorDNAbindingfactor1isoformb Glucagon receptor[Homosapiens]. Glucagon-like peptide2(GLP2)]. (GRPP); Glucagon;Glucagon-likepeptide1(GLP1); Glucagon precursor[Contains:Glicentin-relatedpolypeptide membrane Guanylate cyclase2F;retgc-2;guanylate cyclase2D-like, guanylate Guanylate bindingprotein1,interferon-inducible, 67kd; (Alpha-11). Guanine nucleotide-bindingprotein G(Y),alphasubunit Guanine nucleotide-bindingprotein G(q),alphasubunit. 7 subunit. Guanine nucleotide-bindingproteinG(I)/G(S)/G(O)gamma- guanine Guanine nucleotidebindingprotein(Gprotein),gamma10; (Myostatin). Growth/differentiation factor8precursor(GDF-8) derived morphogeneticprotein1)(CDMP-1). Growth/differentiation factor5precursor(GDF-5)(Cartilage- binding protein). Growth hormonereceptorprecursor(GHreceptor)(Serum Gravin -human (Sargramostim) (Molgramostin). precursor (GM-CSF)(Colony-stimulatingfactor)(CSF) Granulocyte-macrophage colony-stimulatingfactor (Pluripoietin) (Filgrastim)(Lenograstim). Granulocyte colony-stimulatingfactorprecursor(G-CSF) Granulin [Homosapiens]. fragment} GP120, IHRP=ITIheavychain-relatedprotein{internal (256 kdagolgin)(Golgin-245)(72.1protein). Golgi autoantigen,golginsubfamilyA4(Trans-Golgip230)

Description Page 13,H_Plasma_NR Table Four SeparateSources, Andersonetal.Molec.Cell. Proteomics,inpressFeb2004 The HumanPlasma Proteome:ANon-RedundantList DevelopedbyCombinationof P26927 P14210 Q04756 Q9NYH9 P09038 P05546 P02790 P02023 P01922 NP_031381 P34932 P00737 Q02747 T46331 T34547 T46483 T14758 O60813 O60811 T02632 NP_115909 B34087 XP_055865 NP_057612 A46068 AAA73001 P31151 AAB24643 AAD19818 1HUW 1IOJ P58304 NP_067016 NP_008910 P10316 P04196 NP_002143 NP_005327 Q14520 P35557 NP_002106 NP_004703

Accession

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 1 0 0 0 1 1 0 0 1 1 1 1 1 0 0 3 1 Lit 1 0 0 0 0 1 1 0 1 1 1 0 0 1 3 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 1 0 0 1 1 0 0 0 2DEMS 0 1 1 1 0 1 0 3 0 0 1 0 1 1 1 0 0 0 0 0 1 1 1 1 1 1 1 0 0 1 0 1 1 1 1 0 1 0 0 0 0 0 LCMS1

1 0 1 0 0 0 1 1 1 1 1 0 0 0 0 0 0 0 0 1 0 0 1 0 0 0 0 0 1 0 0 1 0 0 1 0 1 1 0 0 1 0 LCMS2 10 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 4 1 1 2 1 1 1 1 1 2 1 1 4 3 4 2 1 1 1 1 1 Total_accessions 1 4 3 4 2 1 1 4 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 4 1 1 2 1 1 1 1 1 2 1 1 1 Total_sources no signal confident signal confident no no no no signal confident signal confident possible signal no no no no no no signal confident no no no no no no no no no no no no signal confident no signal confident signal confident no signal no no no signal signal signal confident no

Signal 0 3 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 TM Homeo boxD12;homeoboxproteinHox-D12;Hox-4.7, human HLA classIIregionexpressedgeneKE4;Ke4gene,mouse, chain (Fragment). HLA classIhistocompatibilityantigen,AW-69(A-28)alpha glycoprotein) (HPRG). Histidine-rich glycoproteinprecursor(Histidine-prolinerich rich Histidine-rich calcium-bindingproteinprecursor;histidine- sapiens]. High densitylipoproteinbindingprotein;vigilin[Homo HGF activatorlikeprotein(Hyaluronanbinding2) (HK4) (Glucokinase). Hexokinase D(EC2.7.1.1)(HexokinasetypeIV)(HK sapiens]. Hexokinase 3;ATP:D-hexose6-phosphotransferase[Homo substrate; human Hepatocyte growthfactor-regulatedtyrosinekinase stimulating protein). (Macrophage stimulatoryprotein)(MSP) Hepatocyte growthfactor-likeproteinprecursor (Hepatopoeitin A). Hepatocyte growthfactorprecursor(Scatterfactor)(SF) (HGF activator)(HGFA). Hepatocyte growthfactoractivatorprecursor(EC3.4.21.-) Hepatocellular carcinoma-associatedantigen66. fibroblast growthfactor)(BFGF)(Prostatropin). Heparin-binding growthfactor2precursor(HBGF-2)(Basic leuserpin 2)(HLS2). Heparin cofactorIIprecursor(HC-II)(Proteaseinhibitor Hemopexin precursor(Beta-1B-glycoprotein). Hemoglobin betachain. Hemoglobin alphachain. 1, beta; Heat shock90kdaprotein1,beta;heat90kd APG-2) (HSP70RY). Heat shock70kdaprotein4(Heat70-related Haptoglobin-1 precursor. (Guanylate cyclaseactivatingprotein1)(Gap-I). Guanylin precursor(Guanylatecyclaseactivator2A) Hypothetical protein dkfzp434g0813.1-human Hypothetical proteindkfzp434c1428.1 -human(fragment) Hypothetical proteindkfzp434b205.1 -human(fragment) Hypothetical proteindkfzp434a163.1 -human(fragment) Hypothetical proteinDJ845O24.5 (Fragment). Hypothetical proteinDJ845O24.3. Hypothetical proteinDJ1186C01.1-human(fragment) Hypothetical proteinCAB56184[Homosapiens]. Hypothetical protein(L1H3'region)-human Hypothetical protein oxidase HAOX3; Hydroxyacid oxidase3;medium-chain2-hydroxyacid Huntington disease-associatedprotein-human Human tyrosinase-relatedgenesegment,product. Human psoriasin(s100a7) DRB1 {DRB1 Human leucocyteantigenbetachainDRmolecule,HLA- [Homo Human homologofMusmusculuswizlprotein[AA4-1561] HUMAN GROWTHHORMONEMUTANT HUMAN APOLIPOPROTEINC-I,NMR,18STRUCTURES homolog). Homeobox proteinCHX10(Ceh-10homeodomaincontaining mouse, homologof

Description Page 14,H_Plasma_NR Table Four SeparateSources, Andersonetal.Molec.Cell. Proteomics,inpressFeb2004 The HumanPlasma Proteome:ANon-RedundantList DevelopedbyCombinationof T12449 T14738 T46460 T12528 T14777 T34566 T12524 T42659 NP_060076 T12496 T42701 XP_055865 XP_048187 XP_047345 XP_036616 S72489 T00356 T00370 T00386 T00063 T00057 T00051 Q92628 Q14156 Q14149 Q14135 Q14699 P42695 NP_060192 NP_079012 T02299 T47168 T17262 T17346 T17253 T08772 T08758 T43500 T17244 T12550 T08751 T17242 T17306 T46914 T08700

Accession

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Lit 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2DEMS 1 1 1 0 0 0 1 0 0 0 0 0 1 1 0 1 1 0 0 0 0 1 1 1 1 0 0 0 0 1 0 1 1 1 0 1 1 1 1 1 0 0 1 1 0 LCMS1

1 1 1 1 0 0 1 0 1 1 1 1 1 0 0 0 0 1 1 1 1 0 1 0 1 0 1 0 0 0 0 0 1 1 0 1 1 0 0 0 1 1 1 0 1 LCMS2 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 Total_accessions 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 2 1 1 1 Total_sources no no possible signal no no no no no no signal no signal no no no possible signal no no no no signal no no no possible signal possible signal no no no possible signal no no no possible signal no no no no no no possible signal no no possible signal no

Signal 0 0 0 0 0 0 0 0 0 2 0 1 0 0 0 0 0 0 0 0 0 1 0 0 0 1 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 TM Hypothetical proteindkfzp586m121.1-human(fragment) Hypothetical proteindkfzp586j0619.1-human(fragment) Hypothetical proteindkfzp586g1721.1-human(fragment) Hypothetical proteindkfzp586g1517.1-human(fragment) Hypothetical proteindkfzp586f1022.1-human(fragment) Hypothetical proteindkfzp586f1019.1-human(fragment) Hypothetical proteindkfzp586b1417.1-human(fragment) Hypothetical proteindkfzp566j164.1-human(fragment) Hypothetical proteindkfzp564l1878.1-human Hypothetical proteindkfzp564g013.1-human(fragment) Hypothetical proteindkfzp564e1616.1-human(fragments) Hypothetical proteindkfzp564a2416.1-human(fragment) Hypothetical proteindkfzp434n222.1-human(fragments) Hypothetical proteindkfzp434n093.1-human(fragment) Hypothetical proteindkfzp434n061.1-human(fragment) Hypothetical proteindkfzp434l1072.1-human(fragment) Hypothetical proteindkfzp434l013.1-human(fragment) Hypothetical proteindkfzp434k1815.1-human(fragment) Hypothetical proteindkfzp434k1210[Homosapiens]. Hypothetical proteindkfzp434i091.1-human(fragment) Hypothetical proteindkfzp434g156.1-human(fragment) Hypothetical protein XP_055865[Homosapiens]. Hypothetical proteinXP_048187[Homo sapiens]. Hypothetical proteinXP_047345[Homo sapiens]. Hypothetical proteinXP_036616[Homo sapiens]. (fragment) Hypothetical proteinTigger2-human transposonMER37 Hypothetical proteinKIAA0690- human (fragment) Hypothetical proteinKIAA0659- human (fragment) Hypothetical proteinKIAA0627-human(fragment) Hypothetical proteinKIAA0437-human(fragment) Hypothetical proteinKIAA0423-human(fragment) Hypothetical proteinKIAA0404-human(fragment) Hypothetical proteinKIAA0232(Fragment). Hypothetical proteinKIAA0143(Fragment). Hypothetical proteinKIAA0136(Fragment). Hypothetical proteinKIAA0121. Hypothetical proteinKIAA0084(HA2022)(Fragment). Hypothetical proteinKIAA0056(Fragment). Hypothetical proteinFLJ20244[Homosapiens]. Hypothetical proteinFLJ12150[Homosapiens]. Hypothetical proteinF23858_1-human(fragment) Hypothetical proteindkfzp762e115.1-human(fragment) Hypothetical proteindkfzp727m111.1-human(fragment) Hypothetical proteindkfzp586o1624.1-human(fragment) Hypothetical proteindkfzp586n1922.1-human(fragment)

Description Page 15,H_Plasma_NR Table Four SeparateSources, Andersonetal.Molec.Cell. Proteomics,inpressFeb2004 The HumanPlasma Proteome:ANon-RedundantList DevelopedbyCombinationof P01308 NP_001558 NP_002215 O14920 P58166 P55103 P09529 P08476 P05111 P01591 S13279 S40354 P49751 P19823 P19827 P06756 P08514 P38570 P53708 P08648 P26006 NP_000876 NP_055134 P01344 P01343 P35858 NP_001544 P24592 P24593 P17936 P18065 P08833 NP_000867 NP_005535 INHUR

Accession 11 1 1 1 0 0 0 1 0 0 0 1 1 1 0 1 1 1 1 1 0 0 0 1 0 0 0 1 1 1 1 1 1 0 0 Lit 14 0 0 0 0 0 0 0 1 0 0 0 0 0 1 0 0 1 1 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 2DEMS 78 0 0 0 0 1 0 1 1 0 1 2 0 1 1 1 0 0 1 0 0 0 1 1 0 1 0 0 0 0 0 1 0 1 1 LCMS1

1 1 0 0 0 0 0 1 0 1 0 1 0 0 0 1 1 0 0 1 1 0 0 0 0 0 0 0 0 0 0 0 0 6 1 LCMS2 109 4 5 1 1 1 1 1 1 1 1 1 2 3 1 1 3 2 1 1 1 1 1 1 1 1 1 1 1 1 2 1 3 1 1 Total_accessions 1 1 1 1 2 1 3 1 4 1 4 4 1 1 1 1 1 1 1 1 1 2 3 1 1 3 2 1 1 1 1 1 1 1 1 Total_sources no signal confident signal confident signal confident signal confident signal confident possible signal no signal no signal confident signal confident signal confident signal signal confident no signal signal possible signal possible signal signal confident signal signal confident signal confident signal confident signal confident signal confident signal confident signal confident signal no signal confident signal confident no no

Signal 0 0 0 0 0 0 0 0 1 0 2 0 0 7 0 0 0 0 0 0 0 0 0 0 0 1 1 1 1 1 1 2 1 2 0 TM Insulin-like growthfactorIAprecursor(IGF-IA) chain precursor(ALS). Insulin-like growthfactorbindingproteincomplexacidlabile Insulin-like growthfactorbindingprotein7[Homosapiens]. (IGFBP-6) (IBP-6)(IGF-bindingprotein6). Insulin-like growthfactorbindingprotein6precursor (IGFBP-5) (IBP-5)(IGF-bindingprotein5). Insulin-like growthfactorbindingprotein5precursor (IGFBP-3) (IBP-3)(IGF-bindingprotein3). Insulin-like growthfactorbindingprotein3precursor (IGFBP-2) (IBP-2)(IGF-bindingprotein2). Insulin-like growthfactorbindingprotein2precursor 12) (PP12). (IGFBP-1) (IBP-1)(IGF-bindingprotein1)(Placental Insulin-like growthfactorbindingprotein1precursor factor-2 Insulin-like growthfactor2receptor; Insulin receptorsubstrate1[Homosapiens]. Insulin receptorprecursor-human Insulin precursor. Inositol polyphosphatephosphatase-like1[Homosapiens]. sapiens]. Inositol 1,4,5-triphosphatereceptor,type3[Homo inhibitor kinasebeta)(NFKBIKB). (I-kappa-B kinase2)(IKK2)(NuclearfactorNF-kappa-B 2.7.1.-) (I-kappa-B-kinasebeta)(ikbkb)(IKK-beta)(IKK-B) Inhibitor ofnuclearfactorkappaBkinasebetasubunit(EC Inhibin betaEchainprecursor(Activinbeta-Echain). Inhibin betaCchainprecursor(Activinbeta-Cchain). Inhibin betaBchainprecursor(Activinbeta-Bchain). (Erythroid differentiationprotein)(EDF). Inhibin betaAchainprecursor(Activinbeta-Achain) Inhibin alphachainprecursor. Immunoglobulin Jchain. Ile-Ser-bradykinin -human(fragment) Ig kappachain-human HYPOTHETICAL PROTEINZAP112/S240II117. derived hyaluronan-associatedprotein) (SHAP). alpha-trypsin inhibitorcomplexcomponent II)(Serum- heavy chainH2)(Inter-alpha-inhibitor heavychain2)(Inter- Inter-alpha-trypsin inhibitorheavy chainH2precursor(ITI derived hyaluronan-associatedprotein) (SHAP). alpha-trypsin inhibitorcomplexcomponent III)(Serum- heavy chainH1)(Inter-alpha-inhibitor1)(Inter- Inter-alpha-trypsin inhibitorheavychainH1precursor(ITI subunit) (CD51antigen). Integrin alpha-Vprecursor(Vitronectinreceptoralpha glycoprotein iib)(gpalpha(gpiib)(CD41antigen). Integrin alpha-iibprecursor(Plateletmembrane (HML-1 antigen)(CD103(Integrinalpha-IEL). Integrin alpha-Eprecursor(Mucosallymphocyte-1antigen) Integrin alpha-8. subunit) (Integrinalpha-F)(VLA-5)(CD49e). Integrin alpha-5precursor(Fibronectinreceptoralpha (VLA-3 alphachain)(CD49c). Integrin alpha-3precursor(GalactoproteinB3)(GAPB3) of VLA-4 Integrin alpha4precursor;antigenCD49D,alpha-4subunit Integral innernuclearmembraneprotein[Homosapiens]. (Somatomedin A). Insulin-like growthfactorIIprecursor(IGF-II) (Somatomedin C).

Description Page 16,H_Plasma_NR Table Four SeparateSources, Andersonetal.Molec.Cell. Proteomics,inpressFeb2004 The HumanPlasma Proteome:ANon-RedundantList DevelopedbyCombinationof NP_000409 NP_000197 A33481 NP_005523 P01579 P01574 P32942 P05362 Q14624 Q06033 Q9UBX7 NP_004126 P07476 P03956 P10145 P13232 P40189 P08887 P05231 P05113 P05112 P01585 Q14116 O95998 Q16552 Q14005 P40933 P35225 P29460 P29459 P22301 P18510 P01584

Accession

1 0 0 1 1 0 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 0 0 1 0 1 1 2 1 1 1 Lit 0 0 0 0 0 0 0 0 0 0 0 0 2 1 0 0 1 0 0 1 0 0 1 0 0 0 0 0 0 0 0 0 0 2DEMS 1 0 0 0 0 1 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 1 1 LCMS1

0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 1 0 0 0 0 0 0 0 1 1 LCMS2 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 2 1 1 2 1 1 1 1 1 2 1 1 1 2 1 5 4 1 Total_accessions 1 1 1 1 1 4 4 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 2 1 1 2 1 1 1 1 1 2 1 Total_sources possible signal signal confident signal confident signal confident signal confident signal signal signal confident possible signal no signal confident signal confident signal confident signal signal confident signal confident signal confident signal confident signal confident no signal confident signal confident no signal signal confident signal confident signal confident signal confident signal confident no signal signal no

Signal 0 0 0 0 0 0 0 0 0 0 0 1 0 3 0 0 1 1 0 0 0 0 0 0 0 0 1 1 0 0 0 0 0 TM Interleukin-18 bindingproteinprecursor(IL-18BP). lymphocyte-associated antigen8)(CTLA-8). Interleukin-17 precursor(IL-17)(IL-17A)(CytotoxicT chemoattractant factor)(LCF). Interleukin-16 precursor(IL-16)(Lymphocyte Interleukin-15 precursor(IL-15). Interleukin-13 precursor(IL-13). (NK cellstimulatoryfactorchain2)(NKSF2). lymphocyte maturationfactor40kdasubunit)(CLMFp40) Interleukin-12 betachainprecursor(IL-12B)(Cytotoxic (NK cellstimulatoryfactorchain1)(NKSF1). lymphocyte maturationfactor35kdasubunit)(CLMFp35) Interleukin-12 alphachainprecursor(IL-12A)(Cytotoxic inhibitory factor)(CSIF). Interleukin-10 precursor(IL-10)(Cytokinesynthesis (ICIL-1RA) (IRAP)(IL-1RN). Interleukin-1 receptorantagonistproteinprecursor(IL-1RA) Interleukin-1 betaprecursor(IL-1beta)(Catabolin). Interleukin 4receptorprecursor;CD124[Homosapiens]. 2 Interleukin 2receptor,gammachain,precursor;Interleukin- Interferon-induced viralresistanceproteinmxa-human Interferon, alpha-inducibleprotein27[Homosapiens]. interferon). Interferon gammaprecursor(IFN-gamma)(Immune Interferon betaprecursor(IFN-beta)(Fibroblastinterferon). R) (cdw50)(CD50antigen). Intercellular adhesionmolecule-3precursor(ICAM-3)(ICAM- (Major grouprhinovirusreceptor)(CD54antigen). Intercellular adhesionmolecule-1precursor(ICAM-1) Inter-alpha-trypsin inhibitorheavychainH4precursor (Serum-derived hyaluronan-associatedprotein)(SHAP). heavy chainH3)(Inter-alpha-inhibitor3) Inter-alpha-trypsin inhibitorheavychainH3precursor(ITI like protease). 11precursor(EC3.4.21.-) (Hippostasin)(Trypsin- precursor; Isocitrate dehydrogenase3(NAD+) gammaisoforma Involucrin. metalloproteinase-1) (MMP-1)(Fibroblast collagenase). Interstitial collagenaseprecursor (EC 3.4.24.7)(Matrix Interleukin-8 precursor(IL-8)(CXCL8) Interleukin-7 precursor(IL-7). antigen). 130) (GP130)(OncostatinMreceptor)(cdw130)(CD130 (Interleukin 6signaltransducer)(Membraneglycoprotein Interleukin-6 receptorbetachainprecursor(IL-6R-beta) (IL-6R 1)(CD126antigen). Interleukin-6 receptoralphachainprecursor(IL-6R-alpha) (BSF-2) (Interferonbeta-2)(Hybridomagrowthfactor). Interleukin-6 precursor(IL-6)(B-cellstimulatoryfactor2) factor I). (Eosinophil differentiationfactor)(Bcell Interleukin-5 precursor(IL-5)(T-cellreplacingfactor)(TRF) (BSF-1) (Lymphocytestimulatoryfactor1). Interleukin-4 precursor(IL-4)(B-cellstimulatoryfactor1) (Aldesleukin). Interleukin-2 precursor(IL-2)(T-cellgrowthfactor)(TCGF) gamma) (IL-1gamma). inducing factor)(IFN-gamma-inducing(Interleukin-1 Interleukin-18 precursor(IL-18)(Interferon-gamma

Description Page 17,H_Plasma_NR Table Four SeparateSources, Andersonetal.Molec.Cell. Proteomics,inpressFeb2004 The HumanPlasma Proteome:ANon-RedundantList DevelopedbyCombinationof NP_055561 NP_055495 P05787 P08727 P05783 S41161 NP_000414 JC4313 PC1102 NP_006112 I52602 NP_002222 Q92876 P16150 P08246 NP_002300 S27954 P02750 P48357 P41159 A55494 NP_002284 NP_002282 P24043 P25391 P20700 JC6084 AAC34573 Q08431 NP_003700 Q9Y2Y9 P21583 P01042 NP_004511 NP_004975 NP_008985 A34630 NP_055626 T00377 T00379 NP_055671 NP_055525 NP_055501 NP_055553

Accession

1 1 0 0 1 1 1 0 0 0 0 0 0 0 0 1 0 0 1 1 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 1 0 0 0 0 0 0 0 1 Lit 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 1 0 1 0 0 0 0 0 0 1 0 0 1 0 0 2DEMS 0 1 1 1 2 1 1 0 0 0 0 0 0 1 0 0 1 1 1 0 1 0 1 1 0 1 0 0 4 0 1 1 0 1 1 1 0 1 0 0 0 1 0 0 LCMS1

0 0 1 1 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 2 1 0 0 1 0 0 0 1 0 1 1 1 0 0 0 0 0 0 0 1 0 0 1 0 LCMS2 1 1 1 3 1 1 1 1 1 1 1 1 1 1 1 1 1 1 8 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 3 1 1 1 1 1 Total_accessions 1 1 1 1 2 1 1 1 1 1 1 1 3 1 1 1 1 1 1 1 1 1 1 1 1 1 1 4 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 Total_sources possible signal no no no no no possible signal signal signal confident signal confident signal confident signal confident no signal signal signal confident signal signal signal confident signal confident signal confident no no no signal confident no no signal confident signal confident no no no no no no no possible signal no no possible signal no no no no

Signal 10 0 1 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 1 4 0 1 0 0 0 0 2 0 0 0 0 0 0 0 0 0 0 0 TM Krueppel-like factor13(TranscriptionBTEB3) (Mast cellgrowthfactor)(MGF). Kit ligandprecursor(C-kitligand)(Stemcellfactor)(SCF) [Contains: Bradykinin]. Kininogen precursor(Alpha-2-thiolproteinaseinhibitor) [Homo Kinesin heavychainmember2;Kinesin,chain,2 (autosomal Kinesin familymember5A;spasticparaplegia10 sapiens]. Kinesin familymember3A;kinesinprotein3A[Homo human(fragment) Kinase-related transformingprotein(ret)(EC2.7.1.-)- KIAA0649 geneproduct[Homosapiens]. KIAA0642 protein-human(fragment) KIAA0640 protein-human(fragment) KIAA0476 geneproduct[Homosapiens]. KIAA0443 geneproduct[Homosapiens]. KIAA0355 geneproduct[Homosapiens]. KIAA0195 geneproduct[Homosapiens]. KIAA0161 geneproduct;likelyorthologofmouseubiquitin KIAA0100 geneproduct[Homosapiens]. , typeIIcytoskeletal8(Cytokeratin8)(K8)(CK8). 19). Keratin, typeIcytoskeletal19(Cytokeratin19)(K19)(CK 18). Keratin, typeIcytoskeletal18(Cytokeratin18)(K18)(CK ,cytoskeletal-human Keratin 2a[Homosapiens]. ,typeI,cytoskeletal-human (fragment) ,typeI,cytoskeletal(cloneHK51)-human [Homo ;Keratin-1;cytokeratinhairalphaprotein Kell bloodgroupprotein-human(fragment) of Kangai 1;CD82antigen;R2leukocytesuppressor (Zyme) (SP59). Kallikrein 6precursor(EC3.4.21.-)(ProteaseM)(Neurosin) (GALGP). (Sialophorin) (CD43antigen)(Galactoglycoprotein) Leukosialin precursor(Leucocyte sialoglycoprotein) (Medullasin). ) (PMN(Bonemarrow serineprotease) Leukocyte elastaseprecursor(EC 3.4.21.37)(Neutrophil factor); Leukemia inhibitoryfactor(cholinergic differentiation Leucine-rich protein-human Leucine-rich alpha-2-glycoproteinprecursor(LRG). (hub219). Leptin receptorprecursor(LEP-R)(OBreceptor)(OB-R) Leptin precursor(Obesityfactor)(Obeseprotein). human Latent transforminggrowthfactor-beta-bindingprotein- sapiens]. Laminin, gamma1precursor;formerlyLAMB2[Homo Laminin, beta1precursor[Homosapiens]. heavy chain). Laminin alpha-2chainprecursor(LamininMchain)(Merosin Laminin alpha-1chainprecursor(LamininAchain). B1. Lambda-interacting protein-human LAM2_HUMAN, partialCDS[Homosapiens]. [Contains: Medin]. E8) (HMFG)(BreastepithelialantigenBA46)(MFGM) Lactadherin precursor(Milkfatglobule-EGFfactor8)(MFG- Kruppel-like factor7(ubiquitous);ubiquitous

Description Page 18,H_Plasma_NR Table Four SeparateSources, Andersonetal.Molec.Cell. Proteomics,inpressFeb2004 The HumanPlasma Proteome:ANon-RedundantList DevelopedbyCombinationof P14151 P13796 NP_004516 NP_002323 NP_002327 P06734 P07195 P18428 NP_002305 NP_002301 O75560 NP_005920 Q16674 P78395 T00209 I39294 P50281 P08493 NP_005914 NP_002400 NP_006690 P11226 O00187 O75556 Q13296 P04156 P21757 P19876 P09603 P00695 A48042 P01229 P51884

Accession

1 1 1 0 0 0 0 1 0 0 0 1 1 1 1 1 0 0 1 1 0 1 0 1 0 0 0 0 1 1 1 0 0 Lit 0 0 1 0 1 0 0 0 0 1 1 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2DEMS 1 1 0 0 0 0 0 0 0 1 0 0 1 1 1 0 1 1 0 0 0 0 0 0 1 1 0 0 0 0 1 0 0 LCMS1

0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 1 0 0 0 1 1 LCMS2 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 2 2 1 1 1 Total_accessions 1 1 1 1 2 2 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 Total_sources signal confident signal confident signal possible signal no signal confident no possible signal signal confident signal confident signal confident no no signal confident signal confident signal confident no signal confident possible signal signal confident signal confident signal confident signal confident signal confident possible signal signal confident signal confident signal confident signal confident signal confident signal confident no no

Signal 0 2 1 0 0 0 1 0 0 1 0 1 1 1 1 0 0 0 1 8 1 0 0 1 8 1 0 0 0 1 0 0 0 TM family 2Amember2). Mammaglobin Aprecursor(Mammaglobin1)(Secretoglobin (ASCR) (CD230antigen). Major prionproteinprecursor(prp)(prp27-30)(prp33-35C) acetylated LDLreceptorIandII). Macrophage scavengerreceptortypesIandII(Macrophage gamma). beta) (CXCL3)(Growthregulatedproteingamma)(GRO- Macrophage inflammatoryprotein-2-betaprecursor(MIP2- (MCSF) (M-CSF). Macrophage colonystimulatingfactor-1precursor(CSF-1) acetylmuramidase C). Lysozyme Cprecursor(EC3.2.1.17)(1,4-beta-N- human Lysosomal membraneglycoproteinlamp-2homolog- subunit) (LSH-beta)(LSH-B)(LH-B). Lutropin betachainprecursor(Luteinizinghormone (KSPG lumican). Lumican precursor(Keratansulfateproteoglycanlumican) endothelial celladhesionmolecule1)(LECAM1)(CD62L). surface antigenLeu-8)(TQ1)(gp90-MEL)(Leukocyte- (Leukocyte adhesionmolecule-1)(LAM-1) L-selectin precursor(Lymphnodehomingreceptor) L-plastin (Lymphocytecytosolicprotein1)(LCP-1)(LC64P). sapiens]. Low densitylipoprotein-relatedprotein2;megalin[Homo macroglobulin Low densitylipoprotein-relatedprotein1(alpha-2- density Low densitylipoproteinreceptor-relatedprotein6;low 2) (ImmunoglobulinE-bindingfactor). (Lymphocyte igereceptor)(FC-epsilon-RII)(CD23)(BLAST- Low affinityimmunoglobulinepsilonFCreceptor (LDH heartsubunit)(LDH-H). L-lactate dehydrogenaseBchain(EC1.1.1.27)(LDH-B) Lipopolysaccharide-binding proteinprecursor(LBP). protein kinase LIM domainkinase1isoform1;motif-containing LIFR geneproduct[Homosapiens]. Melastatin 1 Melanoma-associated antigenp97 isoform1,precursor; (Melanoma inhibitoryactivity). Melanoma derivedgrowthregulatory proteinprecursor interacting protein4)(OIP4). (Preferentially expressedantigen of melanoma)(OPA- Melanoma antigenpreferentiallyexpressed intumors MEGF8 protein-human(fragment) Mcleod syndrome-associatedproteinXK-human (MT1-MMP) (MT1MMP)(MMP-X1). 1) (MTMMP1)(Membrane-type-1matrixmetalloproteinase) 14) (Membrane-typematrixmetalloproteinase1)(MT-MMP Matrix metalloproteinase-14precursor(EC3.4.24.-)(MMP- Matrix Gla-proteinprecursor(MGP). kinase [Homo MAP/ERK kinase5;apoptosissignalregulating Mannosyl (beta-1,4-)-glycoprotein mannosidase [Homo Mannosidase, alpha,class1A,member2;alpha1,2- (Mannan-binding protein)(Mannose-bindinglectin). Mannose-binding proteinCprecursor(MBP-C)(MBP1) protease 2)(MASP-2)(MBL-associatedserine2). 3.4.21.-) (Mannose-bindingproteinassociatedserine Mannan-binding lectinserineprotease2precursor(EC (Lacryglobin) (Secretoglobinfamily2Amember1). Mammaglobin Bprecursor(Mammaglobin2)(LipophilinC)

Description Page 19,H_Plasma_NR Table Four SeparateSources, Andersonetal.Molec.Cell. Proteomics,inpressFeb2004 The HumanPlasma Proteome:ANon-RedundantList DevelopedbyCombinationof P25713 P02795 P16035 P01033 NP_002762 NP_005921 P55160 Q16853 NP_005890 P15529 P35579 P12883 S12460 P02144 P05164 NP_003473 NP_005928 P02686 NP_002352 NP_002432 S71841 A48018 P15941 NP_057279 P08571 Q02241 I37550 P21741 A43336 P10636 NP_005900 P78559 NP_000237 NP_000246 Q02252 P80297

Accession

0 0 0 1 1 0 0 1 0 0 0 0 1 0 1 0 0 1 0 1 0 0 0 0 0 0 0 0 1 1 0 0 0 1 0 1 Lit 0 1 1 1 1 0 0 0 0 0 0 0 0 1 2 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 2DEMS 0 2 0 1 0 1 0 1 0 1 0 0 1 1 0 0 1 1 1 0 1 0 1 1 0 1 1 1 1 0 1 0 0 0 0 0 LCMS1

1 0 0 0 0 0 0 0 1 0 0 0 0 0 0 1 1 0 0 0 0 0 1 0 0 0 0 0 0 0 0 1 0 0 0 0 LCMS2

3 2 1 1 1 1 1 1 1 1 1 1 1 1 2 2 2 1 1 2 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 Total_accessions 1 1 1 1 1 1 1 3 1 1 1 1 1 1 1 1 1 1 1 1 1 2 2 2 1 1 2 1 1 1 1 1 1 1 1 1 Total_sources signal confident signal confident no no signal no signal no no no no signal no no no signal no possible signal signal signal confident no signal confident no no signal confident no no no no no no possible signal no no no signal confident

Signal 14 0 0 0 0 0 0 0 1 0 0 0 0 0 0 1 0 0 0 1 0 0 0 0 0 0 0 0 1 0 0 1 0 0 0 0 TM associated protein)(ARAP)(Neuriteoutgrowth-promoting (MK) (Midgestationandkidneyprotein)(Amphiregulin- Midkine precursor(Neuriteoutgrowth-promotingprotein) -vesicle linkerCLIP-170-human protein) (Pairedhelicalfilament-tau)(PHF-tau). Microtubule-associated proteintau(Neurofibrillarytangle sapiens]. Microtubule-associated protein1Bisoform1[Homo related proteinp80)[Contains:MAP1lightchainLC2]. Microtubule-associated protein1A(MAP1A)(Proliferation- MHC classIItransactivator[Homosapiens]. sapiens]. Methylmalonyl CoenzymeAmutaseprecursor[Homo mitochondrial precursor(EC1.2.1.27)(MMSDH). Methylmalonate-semialdehyde dehydrogenase[acylating], Metallothionein-IL (MT-1L)(MT1X). (GIFB). Metallothionein-III (MT-III)(Growthinhibitoryfactor)(GIF) Metallothionein-II (MT-II)(Metallothionein2A). inhibitor ofmetalloproteinases-2)(CSC-21K). Metalloproteinase inhibitor2precursor(TIMP-2)(Tissue (Collagenase inhibitor). metalloproteinases) (Fibroblastcollagenaseinhibitor) potentiating activity)(EPA)(Tissueinhibitorof Metalloproteinase inhibitor1precursor(TIMP-1)(Erythroid serine, 4; Mesotrypsin preproprotein;trypsin4,brain;protease, [Homo Meningioma expressedantigen6(coiled-coilproline-rich) 1). Membrane-associated proteinHEM-1(Hematopoietic adhesion protein-1)(VAP-1)(HPAO). Membrane copperamineoxidase(EC1.4.3.6)(Vascular 1A1-3B; Membrane component,chromosome17,surfacemarker2; (Trophoblast leucocytecommonantigen)(TLX). Membrane cofactorproteinprecursor(CD46antigen) (NMMHC-A). heavy chain,typeA)(Nonmuscle myosinheavychain-A) heavychain,nonmuscletype A(Cellularmyosin beta). Myosin heavychain,cardiacmuscle betaisoform(myhc- gtmhc-E)- human(fragment) Myosin betaheavychain,skeletal muscle,embryonic(clone Myoglobin. Myeloperoxidase precursor(EC1.11.1.7)(MPO). related gene Myeloid/lymphoid ormixed-lineageleukemia2;ALL1- homolog, Myeloid/lymphoid ormixed-lineageleukemia(trithorax membrane encephalitogenicprotein). Myelin basicprotein(MBP)(MyelinA1protein) Myelin associatedglycoproteinisoformaprecursor; Muts homolog5isoformc[Homosapiens]. Multidrug resistanceprotein,canalicular-human Mucin 7precursor,salivary-human Mucin 1precursor(MUC-1)(Polymorphicepithelialmucin) [Homo M-phase phosphoprotein1;mitotickinesin-likeprotein cell-specific leucine-richglycoprotein). Monocyte differentiationantigenCD14precursor(Myeloid Mitotic kinesin-likeprotein-1(Kinesin-likeprotein5). Mismatch repairproteinMSH2-human factor 2).

Description Page 20,H_Plasma_NR Table Four SeparateSources, Andersonetal.Molec.Cell. Proteomics,inpressFeb2004 The HumanPlasma Proteome:ANon-RedundantList DevelopedbyCombinationof P48681 NP_006148 O43847 NP_004842 NP_004997 Q0UC60 JC7182 NP_002347 S24614 Q9ULV0 P12882 P35580 O43612 O75665 I38480 P15531 P17480 NP_000167 A56959 JC5193 NP_004998 A40043 NP_000426 NP_000824 O60591 T00393 NP_036475 P59666 P22894 O60259 P01303 P07196 P05408 AHNK_HUMAN_1 NP_004531 P13591 Q8K3F9

Accession

1 0 0 1 0 0 0 0 0 0 0 0 0 0 0 2 1 1 1 0 1 0 0 1 1 0 0 0 0 0 1 0 0 0 0 0 0 Lit 0 0 0 0 1 0 0 0 0 0 0 0 0 1 1 0 0 1 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 2DEMS 1 0 0 0 0 0 0 1 0 0 0 0 0 0 1 1 1 0 0 1 0 1 1 0 0 0 0 0 0 1 0 0 0 0 0 0 0 LCMS1

0 0 1 0 0 1 0 0 0 1 1 0 1 0 0 0 0 0 0 0 0 0 1 0 0 0 1 1 1 0 0 1 1 1 0 1 0 LCMS2

1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 Total_accessions 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Total_sources possible signal signal no no no no no no signal confident no no no no no no no no signal confident signal signal confident no no possible signal signal confident signal confident signal confident signal confident no signal confident no signal confident signal confident signal confident no signal confident possible signal signal

Signal 10 12 0 0 0 0 0 0 0 1 1 2 0 0 0 0 0 0 0 0 0 0 0 1 0 4 0 0 0 0 0 0 0 0 4 0 0 TM Neutrophil defensin3precursor(HNP-3)(HP-3)(HP3) CL). metalloproteinase-8) (MMP-8)(PMNLcollagenase)(PMNL- Neutrophil collagenaseprecursor(EC3.4.24.34)(Matrix differentially expressedgene-14protein). (Ovasin) (SerineproteaseTADG-14)(Tumor-associated Neuropsin precursor(EC3.4.21.-)(NP)(Kallikrein8) Neuropeptide Yprecursor(NPY). protein) (Neurofilamentlightpolypeptide)(NF-L). tripletLprotein(68kdaneurofilament polypeptide). endocrine proteinI)(SecretograninV)(Pituitary Neuroendocrine protein7B2precursor(Secretorygranule 2] Neuroblast differentiationassociatedprotein[Segment1of molecule 2 Neural celladhesionmolecule2;neural (N-CAM 140)(NCAM-140)(CD56antigen). Neural celladhesionmolecule1,140kdaisoformprecursor Neu protooncoprotein . sapiens]. Nel-like 1;neuralepidermalgrowthfactor-like1[Homo convertase) (NRDconvertase). Nardilysin precursor(EC3.4.24.61)(N-argininedibasic NAP1 geneproduct[Homosapiens]. NADH dehydrogenase(ubiquinone)Fe-Sprotein1,75kda N-acetylmuramyl-L-alanine amidase SVCT1 -human Na+-dependent vitaminC(L-ascorbicacid)transporter L; Myristoylated alanine-richproteinkinaseCsubstrate;80K- Myosin-binding proteinC,skeletalmuscle-human Myosin Vb(Myosin5B)(Fragment). chain iix/d)(myhc-iix/d). Myosin heavychain,skeletalmuscle,adult1(Myosin (NMMHC-B). heavy chain,typeB)(Nonmusclemyosinchain-B) Myosin heavychain,nonmuscletypeB(Cellularmyosin (Hypocretin-1) (Hcrt1); Orexin-B(Hypocretin-2)(Hcrt2)]. Orexin precursor(Hypocretin)(Hcrt) [Contains:Orexin-A Oral-facial-digital syndrome1protein (Protein71-7A). Olfactory receptor-human(fragment) (Metastasis inhibitionfactornm23) (nm23-H1). kinase A)(Tumormetastaticprocess-associated protein) Nucleoside diphosphatekinaseA(EC2.7.4.6)(NDKA)(NDP (UBF-1) (AutoantigenNOR-90). Nucleolar transcriptionfactor1(Upstreambinding1) (glucocorticoid Nuclear receptorsubfamily3,groupC,member1 Nuclear proteinimportfactor-human Nuclear proteinH731-human B-cells Nuclear factorofkappalightpolypeptidegeneenhancerin Notch proteinhomologTAN-1precursor-human Notch homolog3[Homosapiens]. sapiens]. N-methyl-D-aspartate receptorsubunit2Aprecursor[Homo type IID)(InducibleNOS)(inos). Nitric oxidesynthase,inducibleIID(EC1.14.13.39)(NOS, Nijmegen breakagesyndromeproteinNBS1-human Nicotinamide nucleotidetranshydrogenase[Homosapiens]. 2 (HNP-2)(HP-2)(HP2)]. (Defensin, alpha3)[Contains:HP3-56;Neutrophildefensin

Description Page 21,H_Plasma_NR Table Four SeparateSources, Andersonetal.Molec.Cell. Proteomics,inpressFeb2004 The HumanPlasma Proteome:ANon-RedundantList DevelopedbyCombinationof P20472 P12272 P01270 NP_005964 Q06141 P55259 AAD22671 AAB35047 NP_006380 P02818 NP_000599 Q92871 P14555 NP_006209 P15259 P00558 NP_001074 O00750 S57219 P04180 A35422 JC4859 Q15648 NP_002608 S20313 NP_006784 P32119 A38096 Q13610 NP_006188 1OPP 1OEF P00790

Accession

0 1 0 1 0 0 0 0 1 0 0 1 0 0 0 0 0 0 0 0 0 1 0 1 1 0 1 1 0 0 0 1 0 Lit 0 0 0 0 1 0 1 0 0 0 0 0 1 0 0 0 0 0 1 0 1 1 0 1 0 0 0 0 0 0 1 0 1 2DEMS 0 0 1 1 1 0 1 1 0 1 1 1 1 0 0 0 0 1 0 0 1 1 0 1 0 1 1 1 0 0 0 0 1 LCMS1

0 0 1 0 0 0 0 1 0 1 0 1 1 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 LCMS2 1 2 3 1 2 1 1 2 1 1 2 1 1 2 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 2 1 1 1 Total_accessions 1 1 1 1 2 1 1 1 2 3 1 2 1 1 2 1 1 2 1 1 2 1 1 1 1 1 1 1 1 1 2 1 1 Total_sources signal confident signal confident no no signal confident signal confident signal confident no signal confident no no no no no no signal confident no no no no possible signal possible signal no signal confident possible signal no no no signal confident no signal confident signal no

Signal 0 1 3 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 1 0 0 0 0 0 0 0 0 0 0 2 0 0 TM (PBP) (PPARbindingprotein)(Thyroidhormonereceptor- Peroxisome proliferator-activatedreceptorbindingprotein peroxisome Peroxisome biogenesisfactor10isoform2;peroxin10; Peroxisomal membraneprotein,70K-human dependent Peroxiredoxin 3;antioxidantprotein1;thioredoxin- enhancing factorB)(NKEF-B). specific antioxidantprotein)(TSA)(PRP)(Naturalkillercell (Thioredoxin-dependent peroxidereductase1)(Thiol- Peroxiredoxin 2(EC1.11.1.-)(Thioredoxinperoxidase1) Perlecan precursor-human IEF SSP9502). Periodic tryptophanprotein1homolog( Pericentriolar material1[Homosapiens]. NMR, 28STRUCTURES PEPTIDE OFHUMANAPOLIPOPROTEINC-IRESIDUES1-38, Structures AtPh Peptide OfHumanApoeResidues263-286,Nmr,5 Pepsin Aprecursor(EC3.4.23.1). Parvalbumin alpha. (pthrp) [Contains:Osteostatin(pthrp[107-139])]. Parathyroid hormone-relatedproteinprecursor(PTH-rp) (Parathormone). Parathyroid hormoneprecursor(Parathyrin)(PTH) [Homo Papillary renalcellcarcinoma(translocation-associated) Pancreatitis-associated protein1precursor. protein GP-2)(ZAP75). GP2 precursor(Pancreaticzymogengranulemembrane Pancreatic secretorygranulemembranemajorglycoprotein sapiens]. P85B_HUMAN; PTDINS-3-KINASEP85-BETA[Homo [human, P3=40.2 kdahaptoglobinbeta-chainhomolog{N-terminal} protein Oxygen regulatedproteinprecursor;oxygen containing protein)(BoneGla-protein)(BGP). Osteocalcin precursor(Gamma-carboxyglutamicacid- sapiens]. Orosomucoid 2;alpha-1-acidglycoprotein,type2[Homo Phosphomannomutase 1(EC5.4.2.8)(PMM1)(PMMH-22). phospholipase A2)(NPS-PLA2). phospholipase A2)(GIICspla2)(Non-pancreatic secretory 3.1.1.4) (Phosphatidylcholine2-acylhydrolase) (GroupIIA Phospholipase A2,membraneassociated precursor(EC Phosphoinositide-3-kinase, catalytic, alphapolypeptide; mutase). (BPG-dependent PGAM2)(Muscle-specificphosphoglycerate 3.1.3.13) (PhosphoglyceratemutaseisozymeM)(PGAM-M) Phosphoglycerate mutase2(EC5.4.2.1)5.4.2.4) protein 2)(PRP2). Phosphoglycerate kinase1(EC2.7.2.3)(Primerrecognition specific Phosphodiesterase 5Aisoform1;cgmp-bindingcgmp- beta) (ptdins-3-kinaseC2(PI3K-c2beta)(C2-PI3K). polypeptide (EC2.7.1.137)(Phosphoinositide3-Kinase-C2- Phosphatidylinositol 3-kinaseC2domain-containingbeta Phosphatidylinositol 3-kinase-human (Phospholipid-cholesterol acyltransferase). 2.3.1.43) (Lecithin-cholesterolacyltransferase) Phosphatidylcholine-sterol acyltransferaseprecursor(EC Phosducin, retinal-human human Peroxisome proliferator-activatedreceptorgamma-2- protein RB18A). receptor interactingprotein2)(TRIP2)(p53regulatory associated proteincomplexcomponentTRAP220)(Thyroid

Description Page 22,H_Plasma_NR Table Four SeparateSources, Andersonetal.Molec.Cell. Proteomics,inpressFeb2004 The HumanPlasma Proteome:ANon-RedundantList DevelopedbyCombinationof P05154 P02753 P05155 Q8WMN7 P03952 P22352 P35237 P49763 P36955 NP_002853 S68686 P40425 O94823 P51531 Q10472 P01833 NP_058633 NP_055102 NP_000436 NP_002770 P01127 P04085 NP_006197 Q15102 Q29459 P43034 NP_000433 P02776 P02775 P00747 P05120 P05121

Accession

0 0 0 0 0 0 0 0 0 1 1 0 1 1 1 0 1 1 1 1 1 1 1 1 1 1 0 0 1 0 0 0 Lit 1 0 1 1 1 1 0 1 1 1 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 2DEMS 0 1 0 0 0 1 1 1 0 0 1 1 1 0 1 1 1 0 0 1 0 0 0 1 0 0 2 0 0 1 1 1 LCMS1

1 1 0 0 0 1 0 1 0 0 0 1 0 0 0 0 1 1 1 0 0 0 0 0 0 0 0 0 0 1 0 0 LCMS2 1 1 1 1 1 1 2 1 1 1 2 1 1 2 1 2 2 5 1 2 3 3 3 1 3 1 1 1 3 1 1 1 Total_accessions 1 3 1 1 1 3 1 1 1 1 1 1 1 1 2 1 1 1 2 1 1 2 1 2 2 4 1 2 3 3 3 1 Total_sources signal confident signal signal confident no signal confident signal confident no no no no no signal signal confident no no no no signal confident signal confident signal confident no no no signal confident signal confident signal signal no signal confident signal confident signal confident signal confident

Signal 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 6 0 0 1 0 0 0 0 0 0 1 0 TM subunit). AH 30kdasubunit)(PAF-AHbeta(PAFAH (EC 3.1.1.47)(PAFacetylhydrolase30kdasubunit)(PAF- Platelet-activating factoracetylhydrolaseIBbetasubunit (Lissencephaly-1 protein)(LIS-1). AH 45kdasubunit)(PAF-AHalpha)(PAFAH (EC 3.1.1.47)(PAFacetylhydrolase45kdasubunit)(PAF- Platelet-activating factoracetylhydrolaseIBalphasubunit Platelet/endothelial celladhesionmolecule(CD31antigen); (Iroplact). Platelet factor4precursor(PF-4)(CXCL4)(OncostatinA) cytokine B7)(CXCL7) Platelet basicproteinprecursor(PBP)(Smallinducible Angiostatin]. Plasminogen precursor(EC3.4.21.7)[Contains: serpin) (Urokinaseinhibitor). (Placental plasminogenactivatorinhibitor)(MonocyteArg- Plasminogen activatorinhibitor-2precursor(PAI-2) (Endothelial plasminogenactivatorinhibitor)(PAI). Plasminogen activatorinhibitor-1precursor(PAI-1) (Acrosomal serineproteaseinhibitor). inhibitor) (Plasminogenactivatorinhibitor-3)(PAI3) Plasma serineproteaseinhibitorprecursor(PCI)(ProteinC (PRO2222). Plasma retinol-bindingproteinprecursor(PRBP)(RBP) Plasma proteaseC1inhibitorprecursor(C1Inh)(C1Inh). Plasma phospholipidtransferprotein prekallikrein) (Kininogenin)(Fletcherfactor). Plasma kallikreinprecursor(EC3.4.21.34)(Plasma (gshpx-P) (Extracellularglutathioneperoxidase)(gpx-P). Plasma glutathioneperoxidaseprecursor(EC1.11.1.9) (CAP) (Proteaseinhibitor6)(PI-6). Placental thrombininhibitor(Cytoplasmicantiproteinase) Placenta growthfactorprecursor(plgf). 1). Pigment epithelium-derivedfactorprecursor(PEDF)(EPC- Phosphorylase, glycogen;brain[Homosapiens]. chain, 74K-human Phosphoprotein phosphatase(EC3.1.3.16)2Aregulatory protein PBX2)(G17). Pre-B-cell leukemiatranscription factor-2 (Homeobox (Fragment). Potential phospholipid-transporting atpaseVB(EC3.6.3.1) Possible globaltranscriptionactivator SNF2L2(SNF2-alpha). acetylgalactosaminyltransferase) (galnac-T1). (UDP-galnac:polypeptide, N- 2.4.1.41) (Protein-UDPacetylgalactosaminyltransferase) Polypeptide N-acetylgalactosaminyltransferase(EC receptor) (PIGR)[Contains:Secretorycomponent]. Polymeric-immunoglobulin receptorprecursor(Poly-IG directed), alpha Polymerase (DNA-directed),alpha;polymerase(DNA- Pm5 protein[Homosapiens]. 1, Plectin 1,intermediatefilamentbindingprotein500kda; Pleckstrin andSec7domainprotein[Homosapiens]. chain) (PDGF-2)(c-sis)(Becaplermin). Platelet-derived growthfactor,Bchainprecursor(PDGFB- chain) (PDGF-1). Platelet-derived growthfactor,Achainprecursor(PDGFA- [Homo Platelet-derived growthfactorreceptoralphaprecursor gamma subunit). AH 29kdasubunit)(PAF-AHgamma(PAFAH (EC 3.1.1.47)(PAFacetylhydrolase29kdasubunit)(PAF- Platelet-activating factoracetylhydrolaseIBgammasubunit

Description Page 23,H_Plasma_NR Table Four SeparateSources, Andersonetal.Molec.Cell. Proteomics,inpressFeb2004 The HumanPlasma Proteome:ANon-RedundantList DevelopedbyCombinationof Q15113 P06307 Q9QV29 Q9U6R6 T03719 T03749 G01449 Q9UHG3 JN0067 P11464 Q13219 P20742 P07237 P55345 NP_000299 P34062 NP_005038 P15309 P07288 P41222 S51315 NP_002769 P05165 A53020 P56975 P13674 T02436 P16471 P01236 P01148 P06401 O00469

Accession

1 0 0 0 0 1 2 1 0 0 0 0 0 1 0 1 1 1 0 0 0 1 1 1 0 0 0 0 0 2 1 1 Lit 0 1 1 0 0 0 0 0 0 1 0 0 0 1 1 0 0 1 0 0 0 0 0 0 1 0 0 0 0 0 0 0 2DEMS 0 0 1 0 0 1 0 1 1 0 1 0 1 0 1 0 0 1 0 0 1 0 0 0 0 0 0 0 0 0 1 1 LCMS1

0 0 0 0 0 0 0 0 0 1 0 0 1 0 0 0 0 0 2 0 0 0 0 0 0 0 1 0 0 0 0 0 LCMS2

2 1 1 1 1 1 3 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 2 1 3 Total_accessions 1 1 1 1 1 3 2 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Total_sources no signal confident signal signal signal confident signal confident signal confident no signal confident no no signal signal confident signal confident possible signal signal confident no possible signal possible signal signal confident no signal confident signal confident signal confident no signal confident signal confident signal confident no signal no no

Signal 0 2 0 0 1 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 6 0 0 TM Propionyl-coa carboxylase(EC6.4.1.3)betachainprecursor Neuregulin-3 (NRG-3)]. Pro-neuregulin-3 precursor(Pro-NRG3)[Contains: oxoglutarate-4-dioxygenase alpha-1subunit). 1.14.11.2) (4-PHalpha-1)(Procollagen-proline,2- Prolyl 4-hydroxylasealpha-1subunitprecursor(EC Proline-rich proteinDJ430N08.2-human(fragment) Prolactin receptorprecursor(PRL-R). Prolactin precursor(PRL). (Gonadorelin); gnrh-associatedpeptideI]. (Gonadotropin releasinghormoneI)(gnrh(Luliberin (LHRH I)(Luteinizinghormonereleasing Progonadoliberin Iprecursor[Contains:Gonadoliberin Progesterone receptor(PR). precursor (EC1.14.11.4)(Lysylhydroxylase2)(LH2). Procollagen-lysine,2-oxoglutarate 5-dioxygenase2 (Type 1procollagenC-proteinaseenhancerprotein). (Type IprocollagenCOOH-terminalproteinaseenhancer) Procollagen C-proteinaseenhancerproteinprecursor(PCPE) Procholecystokinin precursor(CCK). Procarboxypeptidase B(EC3.4.17.2)(Fragment). Procalin. Probable thyroidreceptorinteractor-human(fragment) Probable nuclearreceptorcoactivator-human Probable mucinG2[similarity]-human(fragment) Prenylcysteine lyaseprecursor(EC4.4.1.18). Pregnancy-specific beta-1-glycoprotein9precursor-human NCA-2) (PSG95). C/D) (Fetallivernon-specificcross-reactiveantigen-2)(FL- 1) (Pregnancy-specificbeta-1glycoproteinC/D)(PS-beta- Pregnancy-specific beta-1-glycoprotein1precursor(PSBG- protease) (IGFBP-4ase). IGF bindingprotein-4protease)(IGF-dependentIGFBP-4 3.4.24.-) (PAPP-A)(Insulin-likegrowthfactor-dependent Pregnancy-associated plasmaprotein-Aprecursor(EC Pregnancy zoneproteinprecursor. hormone bindingprotein)(P55). (Prolyl 4-hydroxylasebetasubunit) (Cellularthyroid Protein disulfideisomeraseprecursor (PDI)(EC5.3.4.1) Protein arginineN-methyltransferase 2(EC2.1.1.-). for Protective proteinforbeta-galactosidase; Protectiveprotein prosomal protein)(PROS-27)(p27k). (Multicatalytic endopeptidasecomplex iotachain)(27kda (Proteasome iotachain)(Macropain Proteasome subunitalphatype6(EC3.4.25.1) subunit S5basic; Proteasome 26Snon-atpasesubunit5;protease Prostatic acidphosphataseprecursor(EC3.1.3.2). (Seminin) (P-30antigen). (Gamma-seminoprotein) (Kallikrein3)(Semenogelase) Prostate specificantigenprecursor(EC3.4.21.77)(PSA) (PGDS2) (PGDS)(Beta-traceprotein). synthetase) (ProstaglandinD2synthase)(PGD2 (Prostaglandin-D synthase)(Glutathione-independentPGD Prostaglandin-H2 D-isomeraseprecursor(EC5.3.99.2) human Prostaglandin Ereceptor,subtypeEP3spliceformb- metachromatic Prosaposin (variantGaucherdiseaseandvariant coa:carbon dioxideligasealphasubunit). precursor (EC6.4.1.3)(pccasealphasubunit)(Propanoyl- Propionyl-coa carboxylasealphachain,mitochondrial -human

Description Page 24,H_Plasma_NR Table Four SeparateSources, Andersonetal.Molec.Cell. Proteomics,inpressFeb2004 The HumanPlasma Proteome:ANon-RedundantList DevelopedbyCombinationof Q9UK55 AAB22439 NP_002836 NP_002831 NP_004639 Q15436 NP_002725 NP_071739 NP_002731 S68217 S37685 NP_005014 NP_002881 P49792 NP_002864 JC2430 NP_006852 Q92696 NP_000311 NP_002601 P22614 NP_005850 P35247 P07988 P07714 NP_005598 P16109 P07332 NP_002935 NP_061763 NP_061756 Q9Y5I1 P00734 S72441 I52599 A34076

Accession

0 0 0 0 0 0 0 0 2 0 1 1 1 0 1 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Lit 1 0 0 0 1 0 0 0 0 1 1 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 1 2DEMS 1 1 0 1 0 1 1 1 0 1 1 1 1 1 0 1 1 0 0 0 0 0 0 0 1 2 0 0 0 2 0 1 0 0 1 0 LCMS1

0 0 0 0 0 0 0 0 1 1 0 0 0 1 0 0 0 1 1 0 1 1 0 1 0 1 1 0 0 0 0 1 0 0 0 1 LCMS2 1 1 1 1 1 1 1 3 1 1 1 1 1 1 1 2 1 1 1 5 1 1 1 1 2 1 1 1 1 2 1 1 1 1 1 1 Total_accessions 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 4 1 1 1 1 2 1 1 Total_sources signal confident signal confident no no no no no no no possible signal no no no no no no signal confident signal confident no signal signal confident signal confident no no no possible signal signal signal confident signal signal no signal signal confident signal confident no signal confident

Signal 0 0 1 0 3 2 1 1 0 1 1 1 0 0 1 1 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 TM Pulmonary surfactant-associatedproteinAprecursor(SP-A) kinase 1 PTK2 proteintyrosinekinase2isoformb;focaladhesion adhesion molecule3)(LECAM3). 140) (PADGEM)(CD62P)(Leukocyte-endothelialcell P-selectin precursor(Granulemembraneprotein140)(GMP- 2.7.1.112) (C-FES). Proto-oncogene tyrosine-proteinkinaseFES/FPS(EC Proto-oncogene c-ros-1proteinprecursor;transmembrane Protocadherin beta7precursor[Homosapiens]. Protocadherin beta13precursor[Homosapiens]. Protocadherin alpha11precursor(PCDH-alpha11). II). Prothrombin precursor(EC3.4.21.5)(Coagulationfactor Protein-tyrosine-phosphatase (EC3.1.3.48)pi-human Protein-tyrosine phosphatase-human 1precursor -human Protein-tyrosine kinase(EC2.7.1.112)receptortypeeph dependent proteaseinhibitor)(PZI). Protein Z-dependentproteaseinhibitorprecursor(PZ- Protein tyrosinephosphatase;ptpase[Homosapiens]. protein Protein tyrosinephosphatase,receptortype,Mprecursor; precursor; Protein tyrosinephosphatase,receptortype,Fisoform1 Protein tyrosinephosphatase,non-receptortypesubstrate1 Protein transportproteinSec23A(SEC23-relatedA). Protein kinase,camp-dependent,regulatory,typeI,alpha; Protein kinaseNjmu-R1[Homosapiens]. Protein kinaseC,iota[Homosapiens]. Protein kinase(EC2.7.1.37)II,cgmp-dependent-human Protein IEFSSP9126-human(fragments) [Homo Protein geranylgeranyltransferasetypeI,betasubunit activator RAS p21proteinactivator1isoform 1;RASp21protein nucleoporin) (P270). protein Nup358)(Nucleoporin (358kda Ran-binding protein2(ranbp2)(Nuclear porecomplex checkpoint RAD17 homologisoform1;Rad17-like protein;cellcycle Rabphilin-3A-interacting protein- human rab-1c RAB35, memberRASoncogenefamily;ras-relatedprotein alpha)(RABggtasealpha). (RAB geranyl-geranyltransferasealphasubunit)GG RAB geranylgeranyltransferasealphasubunit(EC2.5.1.-) reductase Quinoid dihydropteridinereductase; sapiens]. Pyruvate dehydrogenasekinase,isoenzyme1[Homo Putative serumamyloidA-3protein. stranded Purine-rich elementbindingproteinA;purine-richsingle- (PSP-D). Pulmonary surfactant-associatedproteinDprecursor(SP-D) protein). proteolipid SPL(Phe))(18kdapulmonary-surfactant (6 kdaprotein)(Pulmonarysurfactant-associated Pulmonary surfactant-associatedproteinBprecursor(SP-B) pulmonary surfactant-associatedprotein). (PSP-A) (PSAP)(Alveolarproteinosisprotein)(35kda

Description Page 25,H_Plasma_NR Table Four SeparateSources, Andersonetal.Molec.Cell. Proteomics,inpressFeb2004 The HumanPlasma Proteome:ANon-RedundantList DevelopedbyCombinationof P06400 NP_000318 NP_002893 O60858 P00797 NP_002914 P49802 P78509 I38412 P04626 P05060 NP_008875 O76038 NP_004913 NP_006354 NP_000532 P16615 P04271 P29034 Q9Y265 NP_009193 NP_003152 JC4026 NP_000963 NP_009140 NP_002941 P31350 Q99575 NP_002920 AAB35906 NP_005397 NP_004299 P09455 S16953

Accession

1 0 1 0 0 0 0 1 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 1 0 1 Lit 0 0 1 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 0 0 2DEMS 0 0 1 1 0 1 1 0 1 0 1 1 1 1 0 1 0 0 0 1 1 1 0 0 0 1 1 1 0 0 0 1 1 0 LCMS1

0 0 0 0 0 0 0 0 0 0 1 1 0 0 0 1 0 0 0 0 1 1 0 1 0 0 1 0 0 0 0 0 0 0 LCMS2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 2 1 Total_accessions 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 Total_sources no signal confident no no signal confident no signal confident signal confident signal no no no no possible signal no possible signal no no no no no no signal confident no no no signal no no no no no signal signal confident

Signal 0 0 1 0 0 0 0 0 0 0 0 0 4 0 1 0 0 0 0 1 2 0 0 0 0 0 0 8 0 0 0 0 0 0 TM Ribosomal proteinl7a;60Sribosomalsurfeit3; sapiens]. Ribosomal proteinL35;60SribosomalL35[Homo Ribophorin I[Homosapiens]. 1.17.4.1) (Ribonucleotidereductasesmallchain). Ribonucleoside-diphosphate reductaseM2chain(EC (hpop1). Ribonucleases P/MRPproteinsubunitPOP1(EC3.1.26.5) [Homo Rhodopsin kinase;Gprotein-coupledreceptorkinase1b Rhodopsin [Homosapiens]. p160rock; Rho-associated, coiled-coilcontainingproteinkinase1; CDC42 Rho gtpaseactivatingprotein1;rhogap;p50rhogap; protein) (CRBP). Retinol-binding proteinI,cellular(Cellularretinol-binding Retinoblastoma-binding protein1-human(fragment) Retinoblastoma-associated protein(PP110)(P105-RB)(RB). segment Retinal outersegmentmembraneprotein1;rod Reticulocalbin 2, Reticulocalbin 2,EF-handcalciumbindingdomain; 13). (Putative tumorsuppressorRFP2)(Tripartitemotifprotein chronic lymphocyticleukemiatumorsuppressorLeu5) Ret fingerprotein2(Leukemiaassociated5)(B-cell (Angiotensinogenase). Renin precursor,renal(EC3.4.23.15) Regulator ofG-proteinsignalling2,24kda;G0toG1switch Regulator ofG-proteinsignaling7(RGS7). precursor(EC3.4.21.-). Receptor tyrosinekinase-human(fragment) (Tyrosine kinase-typecellsurfacereceptorHER2)(MLN19). 2.7.1.112) (p185erbb2)(NEUproto-oncogene)(C-erbb-2) Receptor protein-tyrosinekinaseerbb-2precursor(EC [Contains: GAWK peptide;CCBpeptide]. Secretogranin Iprecursor(sgi)(Chromogranin B)(cgb) phosphoprotein 2,24kd; Secreted phosphoprotein2,24kda; secreted Secretagogin. [Homo Sec24-related proteinC; transport proteinSec24C protein Sec23 (S.Cerevisiae)homologB; SEC23-likeproteinB; S-arrestin; S-antigen[Homosapiens]. class 1/2Ca(2+)atpase). slow twitchskeletalmuscleisoform)(Endoplasmicreticulum (Calcium-transporting atpasesarcoplasmicreticulumtype, 3.6.3.8) (Calciumpump2)(SERCA2)(SRCa(2+)-atpase Sarcoplasmic/endoplasmic reticulumcalciumatpase2(EC S-100 protein,betachain. S100 calcium-bindingproteinA2(S-100Lprotein)(CAN19). associated protein54-alpha)(TAP54-alpha). 238) (54kdaerythrocytecytosolicprotein)(ECP-54)(TIP60- (TIP49a) (Pontin52)(Nuclearmatrixprotein238)(NMP interacting protein)(49kdaTBP-interacting Ruvb-like 1(EC3.6.1.-)(49-kdaTATAbox-bindingprotein- [Homo RNA-binding proteinregulatorysubunit;oncogeneDJ1 ribosomal Ribosomal proteinS6kinase,70kda,polypeptide1; Ribosomal proteinS1-likeDNA-binding-human

Description Page 26,H_Plasma_NR Table Four SeparateSources, Andersonetal.Molec.Cell. Proteomics,inpressFeb2004 The HumanPlasma Proteome:ANon-RedundantList DevelopedbyCombinationof P02768 P02787 O14829 G01025 O15269 NP_006206 Q02383 P04279 P49908 A56395 P13500 Q92583 Q16627 XP_006843 XP_005243 XP_031826 AAC83183 XP_002951 Q9UC47 XP_032866 NP_003141 NP_005410 P08240 NP_057122 P04278 NP_059984 Q00587 Q15166 P27169 P02743 P35542 P02735

Accession

1 1 1 0 0 0 0 0 1 0 0 0 0 0 1 0 1 0 1 1 1 1 1 1 0 0 0 0 0 0 1 0 Lit 1 1 1 1 1 1 1 0 1 1 1 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 1 0 0 1 2DEMS 1 0 1 0 0 1 0 0 0 0 0 0 0 1 0 0 0 1 1 0 0 0 0 0 0 1 0 1 1 1 1 0 LCMS1

0 0 0 1 1 1 1 1 0 1 0 0 1 1 0 1 0 0 0 0 0 1 0 1 0 0 0 0 0 0 0 1 LCMS2

1 1 1 1 1 1 2 1 1 1 1 1 2 1 2 1 1 1 3 2 3 4 3 4 1 1 1 2 1 1 2 1 Total_accessions 1 1 2 1 1 2 1 1 1 1 1 1 1 2 1 1 1 1 1 2 1 2 1 1 1 3 2 3 4 3 4 1 Total_sources no no signal confident signal confident signal confident signal confident signal confident signal confident signal confident signal confident no no no no no signal confident no no no possible signal no signal signal confident no signal confident signal signal confident signal signal confident signal confident signal confident no

Signal 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 TM Signal recognitionparticlereceptoralphasubunit(SR- sapiens]. Shwachman-Bodian-Diamond syndromeprotein[Homo binding protein)(ABP). steroid-binding protein)(SBP)(Testis-specificandrogen- Sex hormone-bindingglobulinprecursor(SHBG)(Sex SEX gene[Homosapiens]. Serum proteinMSE55. esterase 3)(Aromatic3). 3.1.8.1) (PON3)(Serumaryldiakylphosphatase(A- Serum paraoxonase/arylesterase3(EC3.1.1.2) esterase 1)(Aromatic(K-45). 3.1.8.1) (PON1)(Serumaryldiakylphosphatase(A- Serum paraoxonase/arylesterase1(EC3.1.1.2) glycoprotein). Serum amyloidP-componentprecursor(SAP)(9.5Salpha-1- expressed serumamyloidAprotein)(C-SAA). Serum amyloidA-4proteinprecursor(Constitutively Amyloid proteinA(AmyloidfibrilAA)]. Serum amyloidAproteinprecursor(SAA)[Contains: Serum albuminprecursor. 1-metal bindingglobulin)(PRO1400). Serotransferrin precursor(Transferrin)(Siderophilin)(Beta- phosphatase 7)(PP7). binding domain)(PPEF)(Serine/threonineprotein 3.1.3.16) (PPEF-1)(ProteinphosphatasewithEFcalcium- Serine/threonine proteinphosphatasewithEF-hands-1(EC Serine/threonine proteinkinase-human transferase 1)(SPT(SPT1). base biosynthesisprotein1)(LCB(Serine-palmitoyl-coa Serine palmitoyltransferase1(EC2.3.1.50)(Longchain Serine (orcysteine)proteinaseinhibitor,cladeA(alpha-1 Semenogelin IIprecursor(SGII). basic protein;Alpha-inhibin-92;Alpha-inhibin-31]. Semenogelin Iproteinprecursor(SGI)[Contains:Seminal Selenoprotein Pprecursor(sep). transmembrane form-human Secretory phospholipaseA2receptorprecursor, (MCAF) (Monocytesecretoryprotein JE)(HC11). protein-1) (Monocytechemotactic andactivatingfactor) chemotactic protein1)(MCP-1)(Monocyte chemoattractant Small induciblecytokineA2precursor (CCL2)(Monocyte and activation-regulatedchemokine) (CCchemokineTARC). Small induciblecytokineA17precursor (CCL17)(Thymus CC-1/CC-3) (HCC-1/HCC-3)(NCC-2). Small induciblecytokineA14precursor(CCL14)(Chemokine (H. Similar tonuclearreceptorsubfamily4,groupA,member1 gene 1 Similar toNDRG1protein(N-mycdownstreamregulated [Homo Similar tohypotheticalproteindkfzp434d2426.1-human to yeast Similar tohumanhsgcn1U77700(PID:g2282576);similar protein Similar toCOX17homolog,cytochromecoxidaseassembly SIMA=56 kdasmallintestinalmucinantigen(Fragment). sapiens]. Signal transducerandactivatoroftranscription5A[Homo Signal transducerandactivatoroftranscription3isoform2; Signal transducerandactivatoroftranscription2;signal alpha) (Dockingprotein(DP-alpha).

Description Page 27,H_Plasma_NR Table Four SeparateSources, Andersonetal.Molec.Cell. Proteomics,inpressFeb2004 The HumanPlasma Proteome:ANon-RedundantList DevelopedbyCombinationof P13501 P13236 P10147 Q9Y4X3 O00175 O00626 P78556 Q12874 Q9H254 P02549 Q13813 NP_004675 P09486 NP_003785 P01241 P35346 P01286 NP_055146 NP_055043 NP_003033 NP_001034 NP_000334 NP_000444 NP_003043 NP_003030 NP_002967 XP_033674 S29185 NP_003073 P42830 P02778

Accession

0 0 0 0 0 1 0 1 0 1 0 0 0 0 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 Lit 0 0 0 0 0 0 0 0 0 1 1 1 1 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2DEMS 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 1 1 1 0 1 0 0 1 1 0 0 0 0 0 LCMS1

0 0 0 0 1 0 1 0 0 0 1 1 1 0 0 0 1 0 1 1 0 0 0 0 0 0 0 0 0 0 0 LCMS2 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Total_accessions 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Total_sources signal confident possible signal signal confident signal no no no no signal confident signal confident no signal confident no signal confident possible signal no no no possible signal possible signal no signal no no no no signal signal confident signal confident signal confident signal

Signal 13 12 21 20 12 12 12 12 14 9 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7 0 TM Solute carrierfamily5(sodiumiodidesymporter),member solute Solute carrierfamily34(sodiumphosphate),member1; transporter), Solute carrierfamily2(facilitatedglucose/fructose channel, Sodium channel,voltage-gated,typeVII,alpha;sodium [Homo Sodium channel,voltage-gated,typeIII,alphapolypeptide Sodium channelproteinII-human(fragment) 43kda; small Small nuclearRNAactivatingcomplex,polypeptide1, activating peptideENA-78). derived neutrophilactivatingprotein78)(Neutrophil- Small induciblecytokineB5precursor(CXCL5)(Epithelial- 10). (Interferon-gamma inducedprotein)(Gamma-IP10)(IP- Small induciblecytokineB10precursor(CXCL10) (TCP228). RANTES protein)(SIS-delta)(Tcell-specificproteinP228) Small induciblecytokineA5precursor(CCL5)(T-cellspecific Small induciblecytokineA4precursor(CCL4) protein 19-1)(G0S19-1protein)(SIS-beta)(PAT464.1). lymphocyte LD78alphaprotein)(G0/G1switchregulatory inflammatory protein1-alpha)(MIP-1-alpha)(Tonsillar Small induciblecytokineA3precursor(CCL3)(Macrophage (eskine) (CuteaneousT-cellattractingchemokine)(CTACK). chemokine ILC)(IL-11Ralpha-locuschemokine)(Skinkine) Small induciblecytokineA27precursor(CCL27)(CC (Eotaxin-2). progenitor inhibitoryfactor-2)(MPIF-2)(CK-beta-6) Small induciblecytokineA24precursor(CCL24)(Myeloid chemotactic protein1)(CCchemokineSTCP-1). (Macrophage-derived chemokine)(StimulatedTcell Small induciblecytokineA22precursor(CCL22) LARC) (Betachemokineexodus-1). (Liver andactivation-regulatedchemokine)(CCchemokine (Macrophage inflammatoryprotein3alpha)(MIP-3-alpha) Small induciblecytokineA20precursor(CCL20) 61) (SAP(SF3a60). Splicing factor3Asubunit3(Spliceosome associatedprotein chain 3)(Beta-IVspectrin). betachain,brain3(Spectrin, non-erythroidbeta Spectrin alphachain,erythrocyte (Erythroidalpha-spectrin). chain) (Alpha-IIspectrin)(Fodrin alphachain). Spectrin alphachain,brain(Spectrin, non-erythroidalpha SPARC-like 1;mast9;hevin[Homosapiens]. BM-40). cysteine) (Osteonectin)(ON)(Basementmembraneprotein SPARC precursor(Secretedproteinacidicandrichin Sorting nexin4[Homosapiens]. (Pituitary growthhormone)(Growthhormone1). Somatotropin precursor(Growthhormone)(GH)(GH-N) Somatostatin receptortype5(SS5R). (Somatocrinin) (Sermorelin). (GRF) (Growthhormone-releasinghormone)(GHRH) Somatoliberin precursor(Growthhormone-releasingfactor) Solute carrierfamily7,(cationicaminoacidtransporter,y+ Solute carrierfamily6,member7;brain-specificL-proline GABA), Solute carrierfamily6(neurotransmittertransporter, Solute carrierfamily6(neurotransmittertransporter, member 1; Solute carrierfamily5(sodium/glucosecotransporter), 5 [Homo

Description Page 28,H_Plasma_NR Table Four SeparateSources, Andersonetal.Molec.Cell. Proteomics,inpressFeb2004 The HumanPlasma Proteome:ANon-RedundantList DevelopedbyCombinationof P00441 P21912 P24347 P08254 P48061 P29508 Q14534 NP_004759 O75533 P10599 P55017 P05452 JE0091 P22105 P24821 P54274 NP_056501 P50990 P10966 P01730 A49029 S33440 AAB30352 NP_003244 NP_055647 S46487 P13686 Q9Y490 NP_003560 NP_005810 JC5922 Q15431 NP_036583 A35363 NP_003060 NP_006298 NP_006744 AAD45960

Accession

1 0 1 0 0 1 0 0 0 1 1 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 1 0 0 1 1 2 0 0 0 Lit 1 0 0 0 0 0 0 0 0 0 0 0 1 0 0 1 0 1 0 1 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2DEMS 0 0 1 1 0 0 0 1 0 0 0 0 0 1 0 0 0 0 1 1 1 0 1 0 0 1 1 1 1 0 1 1 1 0 1 0 1 0 LCMS1

0 0 0 1 0 0 0 0 0 0 0 1 0 0 0 1 0 0 1 0 0 0 0 1 0 0 0 1 0 0 0 1 0 0 0 0 1 0 LCMS2 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 3 1 1 1 1 Total_accessions 1 1 2 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 Total_sources signal confident signal confident no no no no no no signal confident no signal confident signal confident no possible signal no signal confident signal confident no signal confident signal confident no no no signal confident no no no no no no no no signal confident no possible signal no possible signal signal

Signal 12 11 0 0 0 1 1 1 0 3 0 0 0 0 5 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 1 1 0 0 0 0 TM TBC1 domainfamily,member4;TBC(Tre-2,BUB2,CDC16) Taurine transporter-human 3.1.3.2) (TR-AP)(Tartrate-resistantacidatpase)(tratpase). Tartrate-resistant acidphosphatasetype5precursor(EC . Syntaxin 7[Homosapiens]. Syntaxin 6[Homosapiens]. Syntaxin 10-human Synaptonemal complexprotein1(SCP-1protein). Synaptogyrin 4[Homosapiens]. Synapsin Ispliceforma-human regulator of SWI/SNF-related matrix-associatedactin-dependent sapiens]. Sushi-repeat-containing protein,Xchromosome[Homo Surfeit 6;surfeitlocusprotein6[Homosapiens]. EST AA870042.1 Supported byHumanESTH08032.1(NID:g872854),mouse Superoxide dismutase[Cu-Zn](EC1.15.1.1). subunit ofcomplexII). mitochondrial precursor(EC1.3.5.1)(Ip)(Iron-sulfur Succinate dehydrogenase[ubiquinone]iron-sulfurprotein, metalloproteinase-11) (MMP-11)(ST3)(SL-3). Stromelysin-3 precursor(EC3.4.24.-)(Matrix metalloproteinase-3) (MMP-3)(Transin-1)(SL-1). Stromelysin-1 precursor(EC3.4.24.17)(Matrix (Pre-B cellgrowthstimulatingfactor)(PBSF)(hirh). Stromal cell-derivedfactor1precursor(SDF-1)(CXCL12) A). Squamous cellcarcinomaantigen1(SCCA-1)(ProteinT4- epoxidase) (SE). Squalene monooxygenase(EC1.14.99.7)(Squalene [Homo Splicing factorp54;arginine-rich54kdanuclearprotein 155 kdasubunit). 155) (SAP(SF3b155)(Pre-mrnasplicingfactorSF3b Splicing factor3Bsubunit1(Spliceosomeassociatedprotein sulphydryl protein)(SASP). Thioredoxin (ATL-derivedfactor) (ADF) (Surfaceassociated symporter). Thiazide-sensitive sodium-chloride cotransporter(NA-CL protein). Tetranectin precursor(TN)(Plasminogen-kringle 4binding Testis sodiumchannel1-human Tenascin-X precursor(TN-X)(Hexabrachion-like). (Tenascin-C) (TN-C). associated-extracellular matrixantigen)(GP150-225) (Neuronectin) (GMEM)(JI)(Miotendinousantigen)(Glioma- Tenascin precursor(TN)(Hexabrachion)(Cytotactin) Pin2/TRF1). factor 1)(NIMA-interactingprotein2)(Telomeric Telomeric repeatbindingfactor1(TTAGGG TED protein[Homosapiens]. theta). T-complex protein1,thetasubunit(TCP-1-theta)(CCT- (Antigen CD8B). T-cell surfaceglycoproteinCD8betachainprecursor antigen T4/Leu-3). T-cell surfaceglycoproteinCD4precursor(T-cell T-cell receptorVdelta5-Calpharegion-human(fragment) T-cell receptorgammachain-human [human, T-cell receptoralphachainVJregion{clonotypeVa14-jam} lymphoma T-cell lymphomainvasionandmetastasis1;humanT-

Description Page 29,H_Plasma_NR Table Four SeparateSources, Andersonetal.Molec.Cell. Proteomics,inpressFeb2004 The HumanPlasma Proteome:ANon-RedundantList DevelopedbyCombinationof P16473 P01222 Q10587 P20396 P01266 S48161 P35443 P49746 P35442 P07996 P40225 P07204 P01137 P02786 E56695 Q99594 Q9UPN9 Q15545 NP_001510 A56138 P17535 S61541 P19484 P15923 NP_006697 A40225 P20062 P20061 P13797 S68176 I38344 P00750 P13726 P10646 NP_003248 P05543

Accession

1 1 0 0 0 0 0 0 0 0 0 0 0 0 1 1 0 0 0 1 1 1 0 1 1 1 0 1 1 0 1 1 1 1 1 1 Lit 0 0 1 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 1 0 0 0 0 0 1 0 0 0 0 0 1 0 0 0 0 2DEMS 1 1 0 0 0 0 0 0 0 0 0 1 0 1 1 0 1 1 0 1 1 1 0 0 0 0 2 0 0 0 1 0 0 0 1 0 LCMS1

0 0 1 0 0 0 0 1 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 LCMS2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 2 1 1 1 1 2 1 1 1 1 3 1 1 1 Total_accessions 2 1 1 1 1 3 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 Total_sources signal confident signal signal signal confident signal confident signal confident signal signal confident signal confident possible signal no no no no no no no no no no no no signal confident signal confident no no no signal confident signal signal confident no signal confident possible signal signal confident no signal confident

Signal 0 0 0 0 0 0 0 0 0 0 0 0 7 0 0 0 0 0 0 0 0 0 0 1 0 1 0 0 0 0 0 0 0 0 0 0 TM Transcription elongationregulator1;transcriptionfactor Transcription activatorNF-IL6beta-human Transcobalamin IIprecursor(TCII)(TCII). Transcobalamin Iprecursor(TCI)(TCI). T-plastin. TOG protein-human (Reteplase). (tpa) (t-PA)(t-plasminogenactivator)(Alteplase) Tissue-type plasminogenactivatorprecursor(EC3.4.21.68) (Thromboplastin) (CD142antigen). Tissue factorprecursor(TF)(CoagulationIII) inhibitor) (EPI). associated coagulationinhibitor)(LACI)(Extrinsicpathway Tissue factorpathwayinhibitorprecursor(TFPI)(Lipoprotein- zona Tight junctionprotein1isoforma;tight1; Thyroxine-binding globulinprecursor(T4-bindingglobulin). hormone receptor). Thyrotropin receptorprecursor(TSH-R)(Thyroidstimulating alfa). hormone betasubunit)(TSH-beta)(TSH-B)(Thyrotropin Thyrotropin betachainprecursor(Thyroid-stimulating Thyrotroph embryonicfactor. (TRH) (Protirelin). Thyroliberin precursor(Thyrotropinreleasinghormone) Thyroglobulin precursor. Thromboxane-A synthase(EC5.3.99.5)-human Thrombospondin 4precursor. Thrombospondin 3precursor. Thrombospondin 2precursor. Thrombospondin 1precursor. growth anddevelopmentfactor)(MGDF). oncogene ligand)(C-mpl(ML)(Megakaryocyte stimulating factor)(Myeloproliferativeleukemiavirus Thrombopoietin precursor(Megakaryocytecolony antigen). Thrombomodulin precursor(Fetomodulin)(TM)(CD141 Transforming growth factorbeta1precursor(TGF-beta 1). antigen) (T9)(p90). Transferrin receptorprotein1(tfr1) (TR)(tfr)(Trfr)(CD71 human(fragment) Transducin-like enhancer-of-split homolog TLE-4- member 3)(TEAD-3)(DTEF-1). Transcriptional enhancerfactorTEF-5 (TEAdomainfamily protein 33). (RET-fused gene7protein)(Rfg7(Tripartitemotif Transcription intermediaryfactor1-gamma(TIF1-gamma) 55) (TAFII55). Transcription initiationfactorTFIID55kdasubunit(TAFII- related factor1[Homosapiens] 3C; TBP-associatedfactor,RNApolymeraseIII,90kd;B subunit 2;TATAboxbindingprotein(TBP)-associatedfactor protein (TBP)-associatedfactor,RNApolymeraseIII, transcription factorIIIB,90kdsubunit;TATAboxbinding Transcription initiationfactorIIIBisoform1;general Transcription factorREST(version3)-human Transcription factorjun-D. Transcription factorER81-human Transcription factorEB. factor ITF-1)(Kappa-E2-bindingfactor). (Immunoglobulin transcriptionfactor-1)(Transcription binding factorE12/E47)(Transcriptionfactor-3)(TCF-3) Transcription factorE2-alpha(Immunoglobulinenhancer CA150;

Description Page 30,H_Plasma_NR Table Four SeparateSources, Andersonetal.Molec.Cell. Proteomics,inpressFeb2004 The HumanPlasma Proteome:ANon-RedundantList DevelopedbyCombinationof P02766 NP_060069 NP_037469 T43483 A45050 NP_003298 NP_003236 P37802 Q15582 P08112 P01375 P32971 P48023 P29965 O14788 A49013 NP_000359 NP_003313 P07477 P45379 P19429 P02585 P07951 P07226 P06753 NP_036233 P40939 Q07283 NP_006064 P16233 P11150 A47546 AAB36045

Accession

1 1 1 1 1 0 0 0 1 1 1 1 0 0 0 0 0 0 0 1 1 0 0 1 0 0 0 0 0 0 0 0 1 Lit 0 0 0 0 1 0 0 0 0 0 0 1 1 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 2 0 1 0 0 2DEMS 0 1 1 1 0 0 0 0 0 0 0 0 1 1 1 1 0 0 0 0 0 0 1 0 0 1 0 0 1 1 1 0 0 LCMS1

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 1 1 1 1 0 0 0 0 0 0 LCMS2

1 1 1 1 1 1 1 1 2 1 1 1 1 1 2 1 1 1 1 1 1 1 1 4 1 1 1 1 1 1 1 1 1 Total_accessions 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 4 1 1 Total_sources no no no no no signal confident signal confident possible signal possible signal possible signal possible signal possible signal no no no signal confident no no no no no no no no no no signal confident signal confident no no signal confident no possible signal

Signal 0 0 0 0 0 0 1 0 0 0 0 0 1 3 0 0 6 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 TM ). Tropomyosin betachain(Tropomyosin2)(Beta- Tropomyosin alpha4chain(Tropomyosin4)(TM30p1). gamma). Tropomyosin alpha3chain(Tropomyosin3) Tripartite motifproteinTRIM29isoformalpha; hydroxyacyl-coa dehydrogenase(EC1.1.1.35)]. chain enoyl-coahydratase(EC4.2.1.17);Long3- (TP-alpha) (78kdagastrin-bindingprotein)[Includes:Long- Trifunctional enzymealphasubunit,mitochondrialprecursor Trichohyalin. Triadin [Homosapiens]. (Pancreatic lipase)(PL). Triacylglycerol lipase,pancreaticprecursor(EC3.1.1.3) (Hepatic lipase)(HL). Triacylglycerol lipase,hepaticprecursor(EC3.1.1.3) human Triacylglycerol lipase(EC3.1.1.3),hormone-sensitive- Transthyretin; TTR[Homosapiens]. Transthyretin precursor(Prealbumin)(TBPA)(TTR)(ATTR). Transmembrane proteinvezatin[Homosapiens]. homolog; ofinnermitochondrialmembrane22(yeast) human(fragment) Translation initiationfactorIF-2homolog[similarity]- Transketolase (EC2.2.1.1)-human member 2; Transient receptorpotentialcationchannel,subfamilyM, Transglutaminase 3(Epolypeptide, Transgelin 2(SM22-alphahomolog). collagen associatedprotein)(RGD-CAP). precursor (BetaIG-H3)(Kerato-epithelin)(RGD-containing Transforming growthfactor-betainducedproteinIG-H3 (BSC-1 cellgrowthinhibitor)(Polyergin)(Cetermin). (Glioblastoma-derived T-cellsuppressorfactor)(G-TSF) Transforming growthfactorbeta2precursor(TGF-beta2) necrosis factorligandsuperfamily member2)(Cachectin). Tumor necrosisfactorprecursor(TNF-alpha) (Tumor ligand) (CD30-L)(CD153antigen). Tumor necrosisfactorligandsuperfamily member8(CD30 antigen). antigen ligand)(Apoptosis ligand)(APTL)(CD178 Tumor necrosisfactorligandsuperfamilymember6(FAS cell antigenGp39)(CD154antigen). ligand) (CD40-L)(TNF-relatedactivationprotein)(TRAP)(T Tumor necrosisfactorligandsuperfamilymember5(CD40 differentiation factor)(ODF). (TRANCE) (Osteoprotegerinligand)(OPGL)(Osteoclast (RANKL) (TNF-relatedactivation-inducedcytokine) (Receptor activatorofnuclearfactorkappaBligand) Tumor necrosisfactorligandsuperfamilymember11 (fragment) Tumor cellsuppressionproteinHTS1[imported]-human tuberous Tuberous sclerosis1;hamartin;TSC1gene(hamartin); Tubby likeprotein1;Tubby-likeprotein-1[Homosapiens]. Trypsin Iprecursor(EC3.4.21.4)(Cationictrypsinogen). T,cardiacmuscleisoforms(tntc). ,cardiacmuscle. ,skeletalmuscle.

Description Page 31,H_Plasma_NR Table Four SeparateSources, Andersonetal.Molec.Cell. Proteomics,inpressFeb2004 The HumanPlasma Proteome:ANon-RedundantList DevelopedbyCombinationof Q15628 P28908 P26842 P25445 P20333 P19438 O95399 P00749 Q03405 A55662 P30087 O14607 P55854 NP_003334 NP_004779 NP_005145 NP_003931 P09936 P45974 Q9Y4E8 P51451 Q13882 AAB33113 NP_000344 P07101 A42915 NP_003319 P98066 JC6539

Accession

1 1 1 0 1 0 0 0 0 0 0 1 0 0 0 0 0 0 1 0 0 0 0 0 1 1 1 1 1 Lit 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 1 1 1 1 0 0 0 0 2DEMS 0 0 0 0 0 0 0 1 0 1 0 0 1 1 0 0 0 0 0 0 1 0 0 0 1 0 1 1 0 LCMS1

0 0 0 0 0 0 0 1 0 0 1 0 0 0 0 0 0 1 0 1 0 1 0 0 0 0 0 0 0 LCMS2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Total_accessions 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Total_sources signal confident signal signal confident signal signal confident signal confident signal confident no no possible signal no no no no no no no no no no no no no no no signal confident no no signal confident

Signal 0 0 0 0 0 0 0 0 0 0 0 1 1 0 1 2 0 0 0 8 0 1 0 0 0 0 0 0 0 TM Ubiquitin carboxyl-terminalhydrolase15(EC3.1.2.15) kinase) (p55-BLK). Tyrosine-protein kinaseBLK(EC2.7.1.112)(Blymphocyte kinase) (Tyrosine-proteinkinasebrk). Tyrosine-protein kinase6(EC2.7.1.112)(Breasttumor Tyrosine kinasep59fyn(T)[Homosapiens]. cytosolic Tyrosine aminotransferase;aminotransferase, hydroxylase) (TH). Tyrosine 3-monooxygenase(EC1.14.16.2)(Tyrosine3- protein -human(fragment) Type IIcamp-dependentproteinkinaseRIIanchoring protein TXK tyrosinekinase;PTK4protein protein). (TNF-stimulated gene6protein)(Hyaluronate-binding Tumor necrosisfactor-inducibleproteinTSG-6precursor human Tumor necrosisfactorreceptor-associated5homolog- (TNFRSF1A-associated viadeathdomain). domain protein(TNFR1-associatedDEATHprotein) Tumor necrosisfactorreceptortype1associatedDEATH CD30) (KI-1antigen). precursor (CD30Lreceptor)(Lymphocyteactivationantigen Tumor necrosisfactorreceptorsuperfamilymember8 (T14). precursor (CD27Lreceptor)(T-cellactivationantigenCD27) Tumor necrosisfactorreceptorsuperfamilymember7 antigen FAS)(Apo-1antigen)(CD95). precursor (FASLreceptor)(Apoptosis-mediatingsurface Tumor necrosisfactorreceptorsuperfamilymember6 necrosis factorbindingprotein2(TBPII)]. R2) (p75)(CD120b)(Etanercept)[Contains:Tumor precursor (Tumornecrosisfactorreceptor2)(p80)(TNF- Tumor necrosisfactorreceptorsuperfamilymember1B [Contains: Tumornecrosisfactorbindingprotein1(TBPI)]. precursor (p60)(TNF-R1)(TNF-RI)(p55)(CD120a) Tumor necrosisfactorreceptorsuperfamilymember1A Urotensin IIprecursor (U-II)(UII). 3.4.21.73) (upa)(U-). -type plasminogenactivator precursor(EC antigen MO3)(CD87antigen). anchored formprecursor(U-PAR) (Monocyteactivation Urokinase plasminogenactivator surface receptor,GPI- Urea transportprotein-human (Fragment). Unknown proteinfrom2D-pageofplasma(Spot2) Y chromosome). repeat protein(UbiquitouslytranscribedTPRonthe Ubiquitously transcribedYchromosometetratricopeptide Ubiquitin-like proteinSMT3A. yeast; human Ubiquitin-conjugating enzymeE2G2;UBC7homolog, of yeast Ubiquitination factorE4A(UFD2homolog,yeast);homolog Ubiquitin specificprotease8[Homosapiens]. sapiens]. Ubiquitin specificprotease13(isopeptidaseT-3)[Homo cytoplasmic protein9.5)(PGP(PGP9.5). 3.4.19.12) (UCH-L1)(UbiquitinthiolesteraseL1)(Neuron Ubiquitin carboxyl-terminalhydrolaseisozymeL1(EC protease 5)(Deubiquitinatingenzyme(IsopeptidaseT). (Ubiquitin thiolesterase5)(Ubiquitin-specificprocessing Ubiquitin carboxyl-terminalhydrolase5(EC3.1.2.15) protease 15)(Deubiquitinatingenzyme(Unph-2). (Ubiquitin thiolesterase15)(Ubiquitin-specificprocessing

Description Page 32,H_Plasma_NR Table Four SeparateSources, Andersonetal.Molec.Cell. Proteomics,inpressFeb2004 The HumanPlasma Proteome:ANon-RedundantList DevelopedbyCombinationof P13611 Q93034 P33151 P35916 P17948 P15692 P19320 Q96QR1 NP_065778 NP_005087 XP_040906 NP_003441 NP_005997 P12955 O43516 NP_003381 Q9UGP9 NP_006094 NP_004324 Q9UK41 Q96L37 P04275 P31025 O43497 A54972 NP_005653 NP_000213 P04004 P04070 P22891 P07225 P02774 P18206 P08670 NP_005229 BAA03946

Accession

0 0 0 0 0 0 0 0 0 0 0 0 1 1 0 0 0 0 1 1 1 1 1 1 0 0 0 0 0 0 0 0 1 1 1 1 Lit 1 0 0 0 1 1 1 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 1 0 1 1 0 0 0 0 1 1 0 1 1 1 2DEMS 0 0 0 1 0 0 0 0 1 1 0 0 1 0 0 1 0 0 0 0 0 1 0 0 1 0 0 1 2 0 0 0 1 1 0 0 LCMS1

1 1 1 0 0 0 1 0 1 1 0 0 0 1 0 1 0 1 1 1 0 0 0 1 1 0 1 0 0 0 0 0 0 0 0 0 LCMS2 1 1 1 1 1 1 1 1 1 1 1 3 1 1 1 1 2 4 2 1 3 5 2 1 1 1 1 1 1 1 1 1 2 1 1 1 Total_accessions 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 3 1 1 1 1 2 4 2 1 3 4 2 1 1 1 1 1 1 1 1 Total_sources signal confident signal confident signal signal confident signal confident no no no no no no no no possible signal signal confident no no signal signal confident signal confident no no no signal confident signal confident signal confident signal signal confident signal confident no no no signal confident signal no signal confident

Signal 17 19 0 2 0 0 0 0 0 0 0 0 1 0 0 1 1 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 TM Voltage-dependent anionchannel3[Homosapiens]. homolog V-kit Hardy-Zuckerman4felinesarcomaviraloncogene subunit; SomatomedinB]. (V75) [Contains:VitronectinV65subunit;V10 Vitronectin precursor(Serumspreadingfactor)(S-protein) coagulation factorXIV). (Autoprothrombin IIA)(AnticoagulantproteinC)(Blood Vitamin-K dependentproteinCprecursor(EC3.4.21.69) Vitamin K-dependentproteinZprecursor. Vitamin K-dependentproteinSprecursor. component) (GC-globulin)(VDB). Vitamin D-bindingproteinprecursor(DBP)(Group-specific (Metavinculin). . V-ets erythroblastosisvirusE26oncogenehomolog1;Avian Very lowdensitylipoproteinreceptor[Homosapiens]. 2) (PG-M)(Glialhyaluronate-bindingprotein)(GHAP). proteoglycan) (Chondroitinsulfateproteoglycancoreprotein Versican coreproteinprecursor(Largefibroblast (Cullin homolog5)(CUL-5). Vasopressin-activated calcium-mobilizingreceptor(VACM-1) (Cadherin-5) (7B4antigen)(CD144antigen). Vascular endothelial-cadherinprecursor(VE-cadherin) FLT4). 2.7.1.112) (VEGFR-3)(Tyrosine-proteinkinasereceptor Vascular endothelialgrowthfactorreceptor3precursor(EC (Tyrosine-protein kinaseFRT)(Fms-liketyrosine1). receptor) (Tyrosine-proteinkinasereceptorFLT)(Flt-1) 2.7.1.112) (VEGFR-1)(Vascularpermeabilityfactor Vascular endothelialgrowthfactorreceptor1precursor(EC (Vascular permeabilityfactor)(VPF). Vascular endothelialgrowthfactorAprecursor(VEGF-A) (CD106 antigen)(INCAM-100). Vascular celladhesionprotein1precursor(V-CAM1) (High innormal-1)(Secretoglobinfamily3Amember1). Uteroglobin-related protein2precursor(CytokineHIN-1) Zinc fingerprotein295[Homosapiens]. Zinc fingerprotein261[Homosapiens]. Zinc fingerprotein184(Kruppel-like) [Homosapiens]. Zinc fingerprotein174[Homosapiens]. promyelocytic Zinc fingerprotein145(Kruppel-like, expressedin (Proline dipeptidase)(Prolidase)(Imidodipeptidase). Xaa-Pro dipeptidase(EC3.4.13.9)(X-Prodipeptidase) interacting protein)(PRPL-2protein). Wiskott-Aldrich syndromeproteininteracting(WASP like protein Wee1 tyrosinekinase;WEE1+homolog(S.Pombe);wee1- WD-repeat protein5(WDrepeatBIG-3). WAP four-disulfidecoredomain2isoform1precursor; sarcoma V-raf murinesarcomaviraloncogenehomologB1;Murine VPS28 proteinhomolog. Von Willebrandfactor-cleavingproteaseprecursor Von Willebrandfactorprecursor(vwf). prealbumin) (TP)(Tearlipocalin)(Lipocalin1). Von Ebner'sglandproteinprecursor(VEGprotein)(Tear subunit (NBR13)(Cav3.1c). Voltage-dependent T-typecalciumchannelalpha-1G Voltage-dependent calciumchannelalpha1E-3-human

Description Page 33,H_Plasma_NR Table Four SeparateSources, Andersonetal.Molec.Cell. Proteomics,inpressFeb2004 The HumanPlasma Proteome:ANon-RedundantList DevelopedbyCombinationof NP_003452 NP_005093 P25311 Q03164 NP_003421 NP_003413

Accession

0 0 1 0 0 0 Lit

0 0 1 0 0 0 2DEMS

0 0 1 1 0 0 LCMS1

1 1 0 0 1 1 LCMS2

1 1 3 1 1 1 Total_accessions

1 1 3 1 1 1 Total_sources no no signal confident possible signal no signal

Signal

0 0 0 0 0 0 TM Zyxin [Homosapiens]. T/NK cell Zygin 2;fasciculationandelongationproteinzetapre- glycoprotein) (Zn-alpha-2-GP). Zinc-alpha-2-glycoprotein precursor(Zn-alpha-2- Zinc fingerproteinHRX(ALL-1)(Trithorax-likeprotein). Zinc fingerprotein91(HPF7,HTF10)[Homosapiens]. responsive) Zinc fingerprotein42(myeloid-specificretinoicacid-

Description Page 34,H_Plasma_NR Table