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Cytokine Nomenclature

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RayBiotech, Inc. The protein array pioneer company Cytokine Nomenclature Cytokine Name Official Full Name Genbank Related Names Symbol 4-1BB TNFRSF Tumor necrosis factor NP_001552 CD137, ILA, 4-1BB ligand receptor 9 receptor superfamily .2. member 9 6Ckine CCL21 6-Cysteine Chemokine NM_002989 Small-inducible cytokine A21, Beta chemokine exodus-2, Secondary lymphoid-tissue chemokine, SLC, SCYA21 ACE ACE Angiotensin-converting NP_000780 CD143, DCP, DCP1 enzyme .1. NP_690043 .1. ACE-2 ACE2 Angiotensin-converting NP_068576 ACE-related carboxypeptidase, enzyme 2 .1 Angiotensin-converting enzyme homolog ACTH ACTH Adrenocorticotropic NP_000930 POMC, Pro-opiomelanocortin, hormone .1. Corticotropin-lipotropin, NPP, NP_001030 Melanotropin gamma, Gamma- 333.1 MSH, Potential peptide, Corticotropin, Melanotropin alpha, Alpha-MSH, Corticotropin-like intermediary peptide, CLIP, Lipotropin beta, Beta-LPH, Lipotropin gamma, Gamma-LPH, Melanotropin beta, Beta-MSH, Beta-endorphin, Met-enkephalin ACTHR ACTHR Adrenocorticotropic NP_000520 Melanocortin receptor 2, MC2-R hormone receptor .1 Activin A INHBA Activin A NM_002192 Activin beta-A chain, Erythroid differentiation protein, EDF, INHBA Activin B INHBB Activin B NM_002193 Inhibin beta B chain, Activin beta-B chain Activin C INHBC Activin C NM005538 Inhibin, beta C Activin RIA ACVR1 Activin receptor type-1 NM_001105 Activin receptor type I, ACTR-I, Serine/threonine-protein kinase receptor R1, SKR1, Activin receptor-like kinase 2, ALK-2, TGF-B superfamily receptor type I, TSR-I, ACVRLK2 Activin RIB ACVR1B Activin receptor type-1B NM_020328 ACTR-IB, Serine/threonine-protein kinase receptor R2, SKR2, Activin receptor-like kinase 4, ALK-4, ACVRLK4, ALK4 Activin RII A/B ACVR2B Activin receptor type-2B NM_001106 Activin receptor type IIB, ACTR-IIB Activin RIIA ACVR2A Activin receptor type-2A NM_001616 Activin receptor type IIA ADAM17 ADAM17 Disintegrin and NP_003174 TNF-alpha-converting enzyme, metalloproteinase .3 TNF-alpha convertase, Snake domain-containing venom-like protease, CD156b, protein 17 CSVP, TACE ADFP ADFP Adipose differentiation- NP_001113. Adipophilin, ADRP related protein 2 Adipsin Adipsin Adipsin NP_001919 C3 convertase activator, Properdin RayBiotech 中国技术服务热线：400 008 5918 E-mail：[email protected] 公司中英网址：www.raybiotech.com www.raybiotech.cn RayBiotech, Inc. The protein array pioneer company .2 factor D, CFD, DF, PFD, complement factor D AFP AFP Alpha-1-fetoprotein NP_001125. Alpha-fetoglobulin, HPAFP 1 AMPKa1 AMPKa1 5'-AMP-activated protein NP_006242 PRKAA1, AMPK1 kinase catalytic subunit .5. alpha-1 NP_996790 .3. Amylin Amylin Islet amyloid polypeptide NP_000406 Amylin, Diabetes-associated .1. peptide, DAP, Insulinoma amyloid peptide, IAPP AGRP AGRP Agouti related protein NM_001138 AGRT, ART ALCAM ALCAM CD166 antigen NM_001627 Activated leukocyte cell adhesion molecule, CD166, ALCAM, MEMD Amphiregulin AREG Amphiregulin NM_001657 Colorectum cell-derived growth factor, AR, CRDGF, AREG, SDGF ANG ANG Angiogenin NM_001145 ANG, RNASE5, Ribonuclease 5 ANG-1 ANGPT- Angiopoietin-1 NM_001146 ANGPT1, KIAA0003 1 , NM_139290 Angiopoietin-4 ANGPT4 Angiopoietin-4 NM_015985 ANG3, ANG4 Angiopoietin-like ANGPTL Angiopoietin-like 1 NM_004673 ARP-1 1 1 Angiopoietin-like ANGPTL Angiopoietin-like 2 NM_012098 ARP-2 2 2 Angiopoietin-like ANGPTL Angiopoietin-like 3 NP_055310 Angiopoietin 5, Angiopoietin-like 3, 3 3 .1 Angiopoietin-related protein 3, ANG-5 Angiopoietin-like ANGPTL Angiopoietin-like 4 NP_001034 ARP4, HFARP, PGAR, 4 4 756.1 Angiopoietin-related protein 4 NP_647475 .1 Angiostatin PLG Angiostatin NM_000301 98-465AA OF PLASMINOGEN , NP_000292 Apelin Apelin Apelin NP_059109 APLN, APEL, AGTRL1 ligand .3 ApoA2 ApoA2 Apolipoprotein A-II NP_001634 Apolipoprotein A-II(1-76) .1 ApoB ApoB Apolipoprotein B NP_000375 Apolipoprotein B-100, Apo B-48, .2 APOB ApoE ApoE Apolipoprotein E NP_000032 Apo-E .1 Apolipoprotein AI Apo-AI Apolipoprotein A-I NP_000030 ApoA-I .1 APLNR AGTRL1 Apelin receptor NM_005161 HG11, APLNR, AGTRL1, APJ APRIL TNFSF1 Tumor necrosis factor NM_003808 A proliferation-inducing ligand, 3 ligand superfamily TNF- and APOL-related leukocyte member 13 expressed ligand 2, TALL-2, TNF- related death ligand 1, TRDL-1, CD256, TNFSF13, APRIL, TALL2, ZTNF2 Artemin ARTN Artemin NM_057160 Enovin, Neublastin, ARTN, EVN RayBiotech 中国技术服务热线：400 008 5918 E-mail：[email protected] 公司中英网址：www.raybiotech.com www.raybiotech.cn RayBiotech, Inc. The protein array pioneer company Axl UFO Tyrosine-protein kinase AXL oncogene, UFO receptor UFO B7-1 (CD80) CD80 T-lymphocyte activation NM_005191 Activation B7-1 antigen, CTLA-4 antigen CD80 counter-receptor B7.1, B7, BB1, CD80, CD28LG, CD28LG1, LAB7 Bad BAD Bcl2 antagonist of cell NP_004313 Bcl-2-binding component 6, Bcl-2- death .1, like protein 8, BBC6, BCL2L8 NP_116784. 1 Bax Bax Apoptosis regulator BAX NP_004315 Bcl-2-like protein 4, Bcl2-L-4, .1. NP_620116. 1. NP_620118. 1. NP_620119. 1. NP_620120 .1 BCAM BCAM Lutheran blood group NP_001013 B-CAM cell surface glycoprotein, glycoprotein 275.1, Auberger B antigen, F8/G253 NP_005572 antigen, LU, MSK19, CD239 .2 Bcl-2 BCL2 Apoptosis regulator Bcl- NP_000624 B-cell CLL/lymphoma 2, 2 .2 Bcl-w BCL2L2 Bcl-2-like protein 2 NP_004041 Bcl2-L-2, BCLW, KIAA0271, .1 Apoptosis regulator Bcl-W BAFF TNFSF1 B-cell-activating factor NM_006573 TNF- and APOL-related leukocyte 3B belonging to the TNF expressed ligand 1, TALL-1, B family lymphocyte stimulator, BLyS, B cell-activating factor, BAFF, Dendritic cell-derived TNF-like molecule, CD257 BAFF R / TNFRSF B-Cell Activating Factor NM_052945 B cell-activating factor receptor, TNFRSF13C 13C Receptor BAFF receptor, BAFF-R, BLyS receptor 3, CD268, TNFRSF13C, BAFFR, BR3 BCMA / TNFRSF Tumor necrosis factor NM_001192 B-cell maturation protein, CD269, TNFRSF17 17 receptor superfamily TNFRSF17, BCM, BCMA member 17 BD-1 DEFB1 Beta Defensin-1 NM_005218 Defensin, beta 1, DEFB1, BD1, HBD1 BDNF BDNF Brain-derived NM_170735 Abrineurin neurotrophic factor Beta 2M B2M Beta-2-microglobulin NP_004039 .1 Beta-Catenin CTNNB1 Catenin beta-1 XM_001133 CTNNB, Beta-catenin 660 Beta-Defensin 2 DEFB4 Beta Defensin 2 NM_004942 Defensin, beta 2, Skin- antimicrobial peptide 1, SAP1, DEFB4, DEFB102, DEFB2 Beta IG-H3 Beta IG- Transforming growth NP_000349 Transforming growth factor, beta- H3 factor-beta-induced .1 induced, 68kDa, RGD-containing protein ig-h3 collagen-associated protein, BIGH3, BGH3 RayBiotech 中国技术服务热线：400 008 5918 E-mail：[email protected] 公司中英网址：www.raybiotech.com www.raybiotech.cn RayBiotech, Inc. The protein array pioneer company beta-NGF NGFB Nerve growth factor-beta NM_002506 Beta-NGF BID BID BH3-interacting domain NP_001187. p22 BID death agonist 1, NP_932070 .1, NP_932071 .1 BIK BIK B-cell lymphocyte NM_001197 Apoptosis inducer NBK, BP4, BIP1, NBK BIM Bcl2-L- Bcl-2-like protein 11 NP_006529 Bcl2-interacting mediator of cell 11 .1, death NP_619527 .1, NP_996885 .1 BLC CXCL13 B-lymphocyte NM_006419 Small-inducible cytokine B13, B chemoattractant lymphocyte chemoattractant, CXC chemokine BLC, B cell-attracting chemokine 1, BCA-1, ANGIE, BLC, SCYB13 BMP-15 BMP15 Bone morphogenetic NM_005448 Growth/differentiation factor 9B, protein 15 GDF-9B BMP-2 BMP2 Bone morphogenetic NM_001200 BMP-2A protein 2 BMP-3 BMP3 Bone morphogenetic NM_001201 Osteogenin, BMP-3A protein 3 BMP-3b BMP3B Bone morphogenetic NM_004962 Growth/differentiation factor 10, protein 3b GDF-10, Bone-inducing protein, BIP BMP-4 BMP4 Bone morphogenetic NM_130850 BMP-2B, DVR4 protein 4 BMP-5 BMP5 Bone morphogenetic NM_021073 BMP-5 protein 5 BMP-6 BMP6 Bone morphogenetic NM_001718 VGR, BMP-6 protein 6 BMP-7 BMP7 Bone morphogenetic NM_001719 Osteogenic protein 1, OP-1, protein 7 INN=Eptotermin alfa BMP-8 BMP8 Bone morphogenetic NM_001720 Osteogenic protein 2, OP-2, protein 8 BMP8B, Bone morphogenetic protein 8B BMPR-1A BMPR1 Bone morphogenetic NM_004329 Serine/threonine-protein kinase A proteins receptor IA receptor R5, SKR5, Activin receptor-like kinase 3, ALK-3, CD292, ACVRLK3 BMPR-1B BMPR1 Bone morphogenetic NM_001203 CDw293 B proteins receptor IB BMPR-II BMPR2 Bone morphogenetic NM_001204 BMP type II receptor, BMPR-II, proteins receptor II BMPR2, PPH1 BTC BTC Betacellulin NM_001729 Probetacellulin C3a des Arg C3a Complement C3 NP_000055 Complement component 3, C3 and .2 PZP-like alpha-2-macroglobulin domain-containing protein 1 CA125 MUC-16 Mucin-16 NP_078966 Ovarian carcinoma antigen .2 CA125, Ovarian cancer-related RayBiotech 中国技术服务热线：400 008 5918 E-mail：[email protected] 公司中英网址：www.raybiotech.com www.raybiotech.cn RayBiotech, Inc. The protein array pioneer company tumor marker CA125 CA15-3 CA19-9 Calcitonin CALC1 Calcitonin NP_001029 CALCA 124.1, NP_001029 125.1, NP_001732 .1 Carbonic CA-IX Carbonic anhydrase 9 NP_001207 G250, MN, CAIX, Carbonate Anhydrase IX .2. dehydratase IX, Membrane antigen MN, P54/58N, Renal cell carcinoma-associated antigen G250 CART CART Cocaine- and NP_004282 CARTPT amphetamine-regulated .1 transcript protein Caspase-3 CASP-3 Caspase-3 NP_004337 Apopain, Cysteine protease .2, CPP32, CPP-32, Yama protein, NP_116786. SREBP cleavage activity 1, SCA- 1 1, apoptosis-related cysteine peptidase Caspase-8 CASP-8 Caspase-8 NP_001073 ICE-like apoptotic protease 5, 593.1. MORT1-associated CED-3 NP_001073 homolog, MACH, FADD- 594.1. homologous ICE/CED-3-like NP_001219 protease, FLICE, Apoptotic .2. cysteine protease, Apoptotic NP_203519 protease Mch-5, CAP4, MCH5 .1. NP_203520 .1. NP_203522 .1 Cathepsin B CTSB Cathepsin B NP_001899 Cathepsin B1, APP secretase, .1. APPS, CPSB
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  • TNF Decoy Receptors Encoded by Poxviruses

    TNF Decoy Receptors Encoded by Poxviruses

    pathogens Review TNF Decoy Receptors Encoded by Poxviruses Francisco Javier Alvarez-de Miranda † , Isabel Alonso-Sánchez † , Antonio Alcamí and Bruno Hernaez * Centro de Biología Molecular Severo Ochoa, Consejo Superior de Investigaciones Científicas, Campus de Cantoblanco, Universidad Autónoma de Madrid, Nicolás Cabrera 1, 28049 Madrid, Spain; [email protected] (F.J.A.-d.M.); [email protected] (I.A.-S.); [email protected] (A.A.) * Correspondence: [email protected]; Tel.: +34-911-196-4590 † These authors contributed equally. Abstract: Tumour necrosis factor (TNF) is an inflammatory cytokine produced in response to viral infections that promotes the recruitment and activation of leukocytes to sites of infection. This TNF- based host response is essential to limit virus spreading, thus poxviruses have evolutionarily adopted diverse molecular mechanisms to counteract TNF antiviral action. These include the expression of poxvirus-encoded soluble receptors or proteins able to bind and neutralize TNF and other members of the TNF ligand superfamily, acting as decoy receptors. This article reviews in detail the various TNF decoy receptors identified to date in the genomes from different poxvirus species, with a special focus on their impact on poxvirus pathogenesis and their potential use as therapeutic molecules. Keywords: poxvirus; immune evasion; tumour necrosis factor; tumour necrosis factor receptors; lymphotoxin; inflammation; cytokines; secreted decoy receptors; vaccinia virus; ectromelia virus; cowpox virus Citation: Alvarez-de Miranda, F.J.; Alonso-Sánchez, I.; Alcamí, A.; 1. TNF Biology Hernaez, B. TNF Decoy Receptors TNF is a potent pro-inflammatory cytokine with a broad range of biological effects, Encoded by Poxviruses. Pathogens ranging from the activation of inflammatory gene programs to cell differentiation or 2021, 10, 1065.
  • Interleukin-26 Activates Macrophages and Facilitates Killing Of

    Interleukin-26 Activates Macrophages and Facilitates Killing Of

    www.nature.com/scientificreports OPEN Interleukin‑26 activates macrophages and facilitates killing of Mycobacterium tuberculosis Heike C. Hawerkamp 1, Lasse van Geelen 2, Jan Korte2, Jeremy Di Domizio 3, Marc Swidergall 4, Afaque A. Momin 5, Francisco J. Guzmán‑Vega5, Stefan T. Arold 5, Joachim Ernst4, Michel Gilliet 3, Rainer Kalscheuer2, Bernhard Homey1 & Stephan Meller1* Tuberculosis‑causing Mycobacterium tuberculosis (Mtb) is transmitted via airborne droplets followed by a primary infection of macrophages and dendritic cells. During the activation of host defence mechanisms also neutrophils and T helper 1 (TH1) and TH17 cells are recruited to the site of infection. The TH17 cell‑derived interleukin (IL)‑17 in turn induces the cathelicidin LL37 which shows direct antimycobacterial efects. Here, we investigated the role of IL‑26, a TH1‑ and TH17‑associated cytokine that exhibits antimicrobial activity. We found that both IL‑26 mRNA and protein are strongly increased in tuberculous lymph nodes. Furthermore, IL‑26 is able to directly kill Mtb and decrease the infection rate in macrophages. Binding of IL‑26 to lipoarabinomannan might be one important mechanism in extracellular killing of Mtb. Macrophages and dendritic cells respond to IL‑26 with secretion of tumor necrosis factor (TNF)‑α and chemokines such as CCL20, CXCL2 and CXCL8. In dendritic cells but not in macrophages cytokine induction by IL‑26 is partly mediated via Toll like receptor (TLR) 2. Taken together, IL‑26 strengthens the defense against Mtb in two ways: frstly, directly due to its antimycobacterial properties and secondly indirectly by activating innate immune mechanisms. Mycobacterium tuberculosis (Mtb)1–3 is the causing agent of tuberculosis in humans.
  • Transcriptional Control of Tissue-Resident Memory T Cell Generation

    Transcriptional Control of Tissue-Resident Memory T Cell Generation

    Transcriptional control of tissue-resident memory T cell generation Filip Cvetkovski Submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Graduate School of Arts and Sciences COLUMBIA UNIVERSITY 2019 © 2019 Filip Cvetkovski All rights reserved ABSTRACT Transcriptional control of tissue-resident memory T cell generation Filip Cvetkovski Tissue-resident memory T cells (TRM) are a non-circulating subset of memory that are maintained at sites of pathogen entry and mediate optimal protection against reinfection. Lung TRM can be generated in response to respiratory infection or vaccination, however, the molecular pathways involved in CD4+TRM establishment have not been defined. Here, we performed transcriptional profiling of influenza-specific lung CD4+TRM following influenza infection to identify pathways implicated in CD4+TRM generation and homeostasis. Lung CD4+TRM displayed a unique transcriptional profile distinct from spleen memory, including up-regulation of a gene network induced by the transcription factor IRF4, a known regulator of effector T cell differentiation. In addition, the gene expression profile of lung CD4+TRM was enriched in gene sets previously described in tissue-resident regulatory T cells. Up-regulation of immunomodulatory molecules such as CTLA-4, PD-1, and ICOS, suggested a potential regulatory role for CD4+TRM in tissues. Using loss-of-function genetic experiments in mice, we demonstrate that IRF4 is required for the generation of lung-localized pathogen-specific effector CD4+T cells during acute influenza infection. Influenza-specific IRF4−/− T cells failed to fully express CD44, and maintained high levels of CD62L compared to wild type, suggesting a defect in complete differentiation into lung-tropic effector T cells.