Name Colona (Sulpiride + Mebeverine HCl) Film Coated Tablets Composition Each film-coated tablet contains: Sulpiride 25 mg Mebeverine Hydrochloride 100 mg Properties and Actions Colona was carefully designed to achieve effective relief of gastro-intestinal spasms and colics specially when presenting as psychosomatic manifestation of nervous tension, mental stress, anxiety or other psychic states.

Colona contains Sulpiride which is a selective central dopamine D2 receptor blocker. It exerts a mood elevating effect (due to its neuroleptic effect) and anti-emetic action.

Mebeverine is a potent direct antispasmodic acting mainly on the smooth muscles of the gastro- intestinal tract and in particular more effective on the colonic spasm. Mebeverine being not an anticholinergic compound does not produce any of the troublesome side effects of atropine or other anti-spasmodics with atropine-like properties.

Colona is, therefore, an antispasmodic especially effective in functional gastro-intestinal disorders and is particularly safe in elderly group who might be suffering from prostatic enlargement, glaucoma, or cardiac problems. Indications Functional gastro-intestinal disorders. Gastro-intestinal colics (intestinal, colonic, biliary). Irritable bowel syndrome. Diverticular diseases. Post-dysenteric colitis. Control of gastro-intestinal manifestations, accompanying psychogenic and migrainous headache. Side-Effects In therapeutic doses, Colona is considered to possess negligible side effects. In higher doses, sleep disturbance may occur and occasionally galactorrhea and menstrual disturbance may take place. Dosage One tablet 3 - 4 times daily preferably 20 min. before meals. Storage Keep at room temperature (25C) away from light. Keep all medicaments out of reach of children. Presentations Box of 20 or 30 tablets Company Manufactured by: Tenth of Ramadan For Pharmaceutical Industries & Diagnostic Reagents (rameda) 6th of October City - A.R.E.