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Poison or ? A Guide to “Class” Entries

Preface

Most entries in the Poisons List, i.e. the Schedule 10, and the Schedules 1, 2 and 3 to the Pharmacy and Poisons Regulations (Cap. 138A) are in the form of individual and their salts, e.g. “Abacavir; its salts”.

However, some entries are in the form of a “class”, e.g. “Barbituric acid; its salts; its derivatives …”. In such cases, it is not always clear which drugs are members of the class (e.g. , , , , etc. are poisons, being derivatives of barbituric acid).

Likewise, the Ordinance (Cap. 137) applies to the substances specified in Schedule 1 to the Antibiotics Regulations, to their salts and derivatives, and to the salts of such derivatives. Again, it is not always clear which drugs are derivatives of an antibiotic named in the Schedule (e.g. , , , etc. are antibiotics, being derivatives of “” named in the Schedule).

This Guide provides a list of such drugs which are available as registered pharmaceutical products in .

Drugs which are not available as registered pharmaceutical products in Hong Kong are also included in this Guide as far as possible. It should be noted that it is not possible to compile a complete list of all these drugs, simply because there is no limit to the number of “derivatives” a parent chemical can have.

This Guide should be read in conjunction with the Schedules 1, 2, 3, and 10 to the Pharmacy and Poisons Regulations, and Schedule 1 to the Antibiotics Regulations, if the poison/antibiotic classification of a particular pharmaceutical product is to be determined.

Drug Office Department of Health February 2021

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Step-by-step guidance on determining the poison/antibiotic classification of a pharmaceutical product

1. Identify the (first) contained in the pharmaceutical product.

2. If this drug is found in the Poisons List, i.e. the Schedule 10, continue to look for it in the Schedules 1 and 3 to the Pharmacy and Poisons Regulations to determine the “poison” classification of the pharmaceutical product containing this drug. Then look for it in the Schedule 2 to determine if the product is exempted from control as poison under that Schedule.

3. If the drug is not found in the Poisons List, look for it in Schedule 1 to the Antibiotics Regulations.

4. If the drug is found in Schedule 1, the pharmaceutical product will be an antibiotic.

5. If the drug is found neither in the Poisons List nor in Schedule 1 to the Antibiotics Regulations, look for it in the Index to the Guide.

6. If the drug is found in the Index to the Guide, note the Item Number against it, then turn to the Guide itself to identify the Item number and the corresponding Entry in the Poisons List or Antibiotics Schedule of the drug.

7. Repeat steps 2 to 5 with respect to this entry, to determine the classification of the pharmaceutical product containing this drug.

8. If the drug is not found in the Index to the Guide, look for its synonyms (in “Martindale”, the Merck Index, etc), and repeat steps 2 to 7 with respect to each synonym.

9. If none of the synonyms is found in the Index to the Guide after repeating steps 2 to 7, the pharmaceutical product containing the drug will probably be neither a poison nor an antibiotic. However, as mentioned above, the list may not be exhaustive and the actual classification of a product always dictated by the legislations. In addition, the product may also fall under the control of other Ordinances such as Dangerous Drugs Ordinance (Cap. 134).

10. For a multi-component product, repeat the above steps with respect to each component. The “poison” classification of the product itself will be that of the most stringently classified component. In addition, if one component is classified as antibiotic, the product itself will also be classified as an antibiotic.

2 Index to the Guide Drug Name Item No. 112 112 Acetarsol 34 112 Acetoxypregnenolone 131 Acetyl sulfamethoxypyrazine 25 Acetyldigitoxin 64 Acetyldigoxin 64 Acetyldihydrocodeinone 66 Acetylkitasamycin 49 69 Aconitine 5 Adefovir dipivoxil 2 Adiphenine 24 131 Ajmaline 19 Alatrofloxacin 138 Albutrepenonacog alfa 43 32 Alclofenac monoethanolamine 4 131 131 30 131 30 32 38 Allyloestrenol 30 Alpha‐ 51 Alphadolone 23 Alpha‐ 135 Alphamethadol 69 62 Althiazide 54 Altizide 54 30 80 Ambucaine 24 131 Amethocaine 24 100 90 hydrochloride 27 Aminopromazine 112 29 123

3 Index to the Guide Drug Name Item No. Amobarbital 38 Amodiaquin 53 109 109 Amylobarbitone 38 Amylocaine 24 30 30 30 Antihaemophilic factor 43 Antimony potassium 33 Antimony sodium gluconate 33 38 90 131 Arsanilic acid 34 Arsenamide 34 34 methobromide 6 Atropine methonitrate 6 Azaclorzine 112 Azaribine 35 32 94 Azidamphenicol 52 Azilsartan kamedoxomil 36 Azilsartan medoxomil 36 72 56 109 109 32 Barbital 38 Barbitone 38 Beclomethasone 131 Bekanamycin 90 Bemetizide 54 103 Bendrofluazide 54 54 100 Benmoxine 81 Benoxinate 24 79 Benzathine 109 30

4 Index to the Guide Drug Name Item No. 26 Benzodepa 37 Benzoylpas 29 100 Benzthiazide 54 Benzylhydrochlorothiazide 54 Benzylpenicillin 109 Benzylsulfamide 25 32 Betamethadol 69 131 32 30 38 62 32 Bromodiphenhydramine 32 79 32 Bromvalerylurea 44 30 131 Bufotenine 84 38 Butacaine 26 38 Butamben 26 112 Butethamate 24 Butethamine 26 Buthiazide 54 54 38 Butoxycaine 24 123 Butropium 15 Butyl aminobenzoate 26 Cacodylate 34 100 Calcitonin 136 62 Candesartan cilexetil 47 Canfosfamide 103 Carbarsone 34 109 108

5 Index to the Guide Drug Name Item No. 32 Carbocloral 51 122 37 109 112 Cargutocin 108 109 74 Carphenazine 112 11 50 50 50 Cefaloridine 50 50 50 50 50 50 50 50 50 50 50 50 50 50 50 50 50 50 50 50 50 50 50 50 50 50 50 50 50 50 50 50

6 Index to the Guide Drug Name Item No. 50 Ceftolozane 50 50 32 betaine 51 51 103 Chloraminophenamide 56 acetate 30 Chlornaphazine 103 131 Chloroprocaine 24 31 31 30 Chlorphenamide 56 Chlorpheniramine 32 112 112 theophyllinate 134 131 71 Cimetropium 14 83 Cinchophen 114 32 72 32 32 92 131 131 58 32 131 62 56 55 131 122 62 30 109 62 30 Cocaethylene 10

7 Index to the Guide Drug Name Item No. Codoxime 65 8 Colistimethate sodium 60 Colpormon 30 Combelen 112 131 131 Crotarbital 38 Cyacetacide 82 112 38 Cyclodrine 24 Cyclomethycaine 24 54 38 24 103 54 Cymarin 129 32 30 Dalfopristin 119 30 Deanol benzilate 24 bromide 118 131 Defosfamide 103 acetate 30 62 Demeclocycline 133 30 108 Denopterin 28 Deoxycorticosterone 131 Deprenyl 100 32 Deserpidine 19 Deslanoside 64 142 30 131 Desoxymethasone 131 131 32 32 96

8 Index to the Guide Drug Name Item No. 120 85 Diacetyldihydromorphine 67 Diacetylmorphine 17 Diaziquone 37 90 51 131 Dichlorphenamide 56 109 Dienoestrol 30 30 Diethazine 112 Diethylpropion 100 30 Diethylthiambutene 70 131 131 131 Digitalin 64 64 Digoxin 64 128 Diisopropanolamine 40 31 30 26 Dimethylaminoethyl reserpilinate 19 Dimethylthiambutene 70 32 131 32 Dipivefrin 131 Dipyrone 105 72 Divalproex sodium 140 112 d‐Norpseudoephedrine 11 74 3 Doxycycline 133 Drosprienone 30 30 30 Eburnamonine 21 Efmoroctocog alfa 43

9 Index to the Guide Drug Name Item No. Eftrenonacog alfa 43 Elcatonin 136 Elcometrine 30 32 32 122 11 109 30 32 Epinephrine 131 3 30 54 Epoetin alfa 125 Epoetin Beta 125 Epoetin Delta 125 Epoetin Gamma 125 Epoetin Kappa 125 Epoetin Lambda 125 Epoetin Omega 125 Epoetin Theta 125 Epoetin Zeta 125 Eptacog alfa (activated) 43 30 12 12 12 12 12 Ergotoxine 12 109 57 Eseridine salicylate 7 91 62 30 103 30 30 30 30 Ethacizine 112 Ethinyloestradiol 30 30 Ethotoin 115

10 Index to the Guide Drug Name Item No. Ethybenztropine 39 62 Ethylamphetamine 100 thioctate 135 Ethylmethylthiambutene 70 Ethyloestrenol 30 Ethynodiol 30 dicloacetate 131 73 30 Factor IX recombinant 43 Factor VIIa recombinant 43 Factor VIII 43 Factor VIII recombinant 43 Felbinac 40 142 100 100 Fenprostalene 122 15 74 Flucinolone 131 Flucinonide 131 Flucloronide 131 109 62 131 acetate 30 Flumethasone 131 Flumethiazide 54 32 131 62 butyl 131 131 131 30 acetate 131 112 acetate 131 131 Flurandrenolide 131 62 131 62 Fluzacort 131

11 Index to the Guide Drug Name Item No. Follicle‐stimulating 116 Follitropin 116 Follitropin alfa 116 Follitropin beta 116 Follitropin delta 116 30 131 Formosulfathiazole 25 Formylsulfamethine 25 30 FSH 116 30 Fusidates 76 77 Gelsemine 13 122 100 30 30 30 30 Gitoxin 64 Glyceryl p‐aminobenzoate 26 Glyconiazide 89 139 62 131 Halobetasol 131 131 acetate 131 62 Heptabarbital 38 17 118 Hexaminolevulinate hydrochloride 27 38 Hexoestrol 30 131 Hexylcaine 24 31 32 Homofenazine 112 Human growth hormone 116 Hydrargaphen 95 54 131

12 Index to the Guide Drug Name Item No. 131 54 Hydroquinine 124 53 Hydroxyestrone diacetate 30 112 Hydroxyprogesterone 30 Hydroxytetracaine 24 Hyoscine‐N‐butyl bromide 14 61 109 56 Ipratropium 6 89 78 Isobutyl p‐aminobenzoate 26 81 131 Isoproterenol 131 62 49 Lanatosides 64 L‐ 59 50 32 Leucomycin 49 Leucovorin 75 121 Levobupivacaine 46 32 32 Levodopa 68 106 112 30 Levophenacylmorphan 87 85 LH 116 Limaprost 122 Liothyronine 136 16 58 Lonoctocog alfa 43 62 62 62

13 Index to the Guide Drug Name Item No. etabonate 131 116 Lutropin alfa 116 133 Lynoestrenol 30 Lypressin 142 131 100 54 109 133 62 30 30 131 30 Meglumine antimonate 33 Melarsoprol 34 acetate 30 79 103 116 Meparfynol 99 100 Mephenytoin 115 30 131 31 112 Merbromin 95 Mercurochrome 95 112 30 MestranolMethandienone 30 62 109 Methacycline 133 Methadol 69 100 30 Methandrostenolone 30 Methanearsonic acid 34 89 31 Methenolone 30 Methetoin 115

14 Index to the Guide Drug Name Item No. sodium 109 Methisopurinol 88 38 28 Methotrimeprazine 112 Methscopolamine bromide 14 54 hydrochloride 27 Methyl‐1‐ 30 Methyladrenaline 131 38 3‐Methyl‐5‐phenylhydantoin 115 131 30 9 112 Meturedepa 37 109 MiboleroneMoxestrol 30 62 Mikamycin 143 133 131 Monomethylarsinate 34 79 Moramide intermediate 98 Moroctocog alfa 43 methobromide 17 58 Moxalactam 50 32 Moxidectin 102 Mycophenolate mofetil 104 121 121 30 Neoarsphenamine 34 78 31 17 62 62 Nitropentaerythritol 110 N‐Methylacetanilide 1 N‐Methylephedrine 11 acetate 30

15 Index to the Guide Drug Name Item No. Nonacog alfa 43 Noprylsulfamide 25 Noradrenaline 131 62 Nordefrin 131 30 30 30 Norethynodrel 30 30 30 30 30 30 Norlevorphanol 86 30 30 Octocog alfa 43 97 Oestrogen 30 32 142 Ornoprostil 122 Otilonium 24 Ouabain 129 30 109 30 32 62 62 14 112 Oxophenarsine 34 Oxophenylarsine 34 24 24 Oxycinchophen 83 30 30 p‐Aminosalicylic acid hydrazide 29 48 131 Paraoxon 63 Parathiazine 112 Parethoxycaine 24

16 Index to the Guide Drug Name Item No. Pasiniazide 89 41 G 109 Penicillin V 109 30 Pentamethonium bromide 118 Pentobarbital 38 100 Peplomycin 42 112 Perfosfamide 103 Pericyazine 112 Perimethazine 112 Perindopril 111 112 101 100 81 81 32 100 Phenobarbital 38 109 81 100 Phenyl aminosalicylate 29 2‐Phenylcinchoninic acid 114 100 32 115 Phthalylsulfacetamide 25 25 Physostigmine 7 18 41 62 79 112 109 Pipothiazine 112 100 Piprinhydrinate 32 45 109 109 Polyestradiol 30

17 Index to the Guide Drug Name Item No. Polyestriol 30 54 Potassium cyanide 82 Prajmaline 19 30 62 131 103 131 131 131 Prednival 131 131 131 100 Procaine 24 Procaine Penicillin 109 112 112 30 116 30 112 30 30 38 Propanocaine 24 Proparacaine 24 Properidine 101 112 Propionylpromazine 112 Propoxycaine 24 Prothrombin 43 Protoveratrines 20 Proxibarbal 38 Proxymetacaine 24 11 84 84 Pyrazinobutazone 113 Pyrilamine 31 62 32 Quinalbarbitone 38 30 Quinestradiol 30

18 Index to the Guide Drug Name Item No. 30 124 Quinupristin 119 Racemethadol 69 Raubasine 19 Rescinnamine 19 19 126 126 126 126 131 Rioprostil 122 133 Roxarsone 34 72 32 Salazosulfadimidine 25 Salcatonin 136 Salinazid 89 14 Secbutabarbital 38 38 Selamectin 102 100 Sequifenadine 32 32 78 Sodium cyanide 82 Sodium thioctate 135 Somatotropin 116 Somatrem 116 Somatropin 116 79 Stanolone 30 30 Stibocaptate 33 Stibophen 33 Strophanthin 129 25 109 Sulfabenz 25 Sulfabenzamide 25 Sulfabromomethazine 25 Sulfacarbamide 25 25

19 Index to the Guide Drug Name Item No. Sulfachlorpyridazine 25 Sulfachrysoidine 25 Sulfaclozine 25 Sulfacytine 25 25 Sulfadiazine Silver 25 25 25 25 25 Sulfaethidole 25 25 25 Sulfaguanole 25 Sulfaloxic acid 25 25 25 Sulfamethomidine 25 25 Sulfamethoxydiazine 25 25 Sulfamethylthiazole 25 Sulfametopyrazine 25 25 Sulfamidochrysoidine 25 Sulfamonomethoxine 25 25 Sulfamoylsulfanilanilide 25 25 25 Sulfaperine 25 25 Sulfapyrazole 25 25 Sulfaquinoxaline 25 25 Sulfaside 34 Sulfasomizole 25 Sulfasymazine 25 25 Sulfathiazole Silver 25 25 25 Sulfatroxazole 25 25 Sulfonethylmethane 130

20 Index to the Guide Drug Name Item No. Sulfoniazide 89 112 122 109 T3 136 T4 136 38 100 Teclothiazide 54 74 141 72 62 Tenofovir Alafenamide 132 Tenofovir Disoproxil 132 142 30 Testosterone 30 24 48 30 62 66 31 Thiamiprine 94 52 Thiazinamium methylsulfate 112 Thiazolinobutazone 113 112 Thioctamide 135 Thioctic acid amide 135 Thioguanine 94 Thiopentone 38 112 112 112 Thiothixene 55 31 Thromboplastin 43 Thyroid‐stimulating hormone 116 Thyrotropin 116 Thyroxine 136 117 30 109 Tigecycline 133

21 Index to the Guide Drug Name Item No. Tilmicosin 127 79 30 131 78 32 30 131 62 54 Trichlormethine 103 Trichlorourethan 137 137 Trifluomeprazine 112 112 79 112 136 24 30 32 Trimoprostil 122 Tripamide 56 Tripolidine 32 32 103 107 Trometamol thioctate 135 Tryparsamide 34 TSH 116 Tubocurarine 9 127 139 103 Uredepa 37 116 Valethamate 24 117 140 38 21 Vincamine 21 21 38 Ximelagatran 93 56

22 Index to the Guide Drug Name Item No. 22 55 δ‐yohimbine 19

23 The Guide Item Entry in the Poisons List or Drugs Covered by the Entry No. Antibiotics Schedule 1 : alkyl N‐Methylacetanilide Adefovir; its salts; its esters; 2 Adefovir dipivoxil their salts Doxorubicin 3 Adriamycin Epirubicin 4 Alclofenac; its complexes Alclofenac monoethanolamine 5 : Aconite Aconitine Atropine methobromide Atropine methonitrate 6 Alkaloids: Atropine Ipratropium

Eseridine salicylate 7 Alkaloids: Calabar bean Physostigmine 8 Alkaloids: Colchicum Colchicine Metocurine 9 Alkaloids: ; curare bases Tubocurarine Alkaloids: Ecgonine; its esters 10 Cocaethylene and Ephedrine N‐Methylephedrine 11 Alkaloids: Ephedra d‐Norpseudoephedrine (Cathine) Pseudoephedrine

Ergometrine 12 Alkaloids: Ergotamine Ergotoxine (mixture of Ergocristine, Ergocryptine & Ergocornine)

13 Alkaloids: Gelsemine Hyoscine‐N‐butyl bromide 14 Alkaloids: Hyoscine Methscopolamine bromide Oxitropium bromide (= Scopolamine) Butropium 15 Alkaloids: Fentonium bromide 16 Alkaloids: Lobelia Lobeline Diacetylmorphine (Heroin) Alkaloids: Morphine; its esters 17 Morphine methobromide and ethers Nicomorphine 18 Alkaloids: Pilocarpus Pilocarpine

24 The Guide Item Entry in the Poisons List or Drugs Covered by the Entry No. Antibiotics Schedule Ajmaline Deserpidine Dimethylaminoethyl reserpilinate Alkaloids: Rauwolfia; their 19 Prajmaline derivatives Raubasine (δ‐yohimbine) Rescinnamine Reserpine 20 Alkaloids: Veratrum Protoveratrines Eburnamonine Vinblastine 21 Alkaloids: Vinca Vincamine Vincristine 22 Alkaloids: Yohimba Yohimbine 23 Alphadolone; its esters Alphadolone acetate

Amino‐ esterified with benzoic acid, phenylacetic acid, phenylpropionic acid, cinnamic Adiphenine, Ambucaine, Amethocaine (Tetracaine), Amylocaine, acid or the derivatives of these Benoxinate (Oxybuprocaine), Butethamate, Butoxycaine, Chloroprocaine, acids; their salts (except Cyclodrine, Cyclomethycaine, Cyclopentolate, Deanol benzilate, 24 procaine when in a preparation Hexylcaine, Hydroxytetracaine, Otilonium, Oxybutynin, Parethoxycaine, containing any substance to Procaine, Propanocaine, Proparacaine (Proxymetacaine), Propoxycaine, which the Antibiotics Ordinance Trimebutine, Valethamate (Cap. 137) for the time being applies)

Acetyl sulfamethoxypyrazine, Benzylsulfamide, Formosulfathiazole, Formylsulfamethine, Noprylsulfamide, Phthalylsulfacetamide, Phthalylsulfathiazole, Salazosulfadimidine, Succinylsulfathiazole, Sulfabenz, Sulfabenzamide, Sulfabromomethazine, Sulfacarbamide, para‐ Sulfacetamide, Sulfachlorpyridazine, Sulfachrysoidine, Sulfaclozine, Aminobenzenesulphonamide; Sulfacytine, Sulfadiazine, Sulfadiazine Silver, Sulfadicramide, its salts; derivatives of para‐ Sulfadimethoxine, Sulfadimidine, Sulfadoxine, Sulfaethidole, aminobenzenesulphonamide Sulfafurazole, Sulfaguanidine, Sulfaguanole, Sulfaloxic acid, 25 having any of the hydrogen Sulfamerazine, Sulfamethizole, Sulfamethomidine, Sulfamethoxazole, atoms of the para‐amino group Sulfamethoxydiazine, Sulfamethoxypyridazine, Sulfamethylthiazole, or of the sulphonamide group Sulfametopyrazine, Sulfametrole, Sulfamidochrysoidine, substituted by another radical; Sulfamonomethoxine, Sulfamoxole, Sulfamoylsulfanilanilide (= their salts Sulfanilamide), Sulfanitran, Sulfaperine, Sulfaphenazole, Sulfapyrazole, Sulfapyridine, Sulfaquinoxaline, Sulfasalazine, Sulfasomizole, Sulfasymazine, Sulfathiazole, Sulfathiazole Silver, Sulfathiourea, Sulfatolamide, Sulfatroxazole, Sulfisomidine

25 The Guide Item Entry in the Poisons List or Drugs Covered by the Entry No. Antibiotics Schedule Benzocaine Butacaine Butethamine para‐Aminobenzoic acid, esters 26 Butyl aminobenzoate (Butamben) of; their salts Dimethocaine Glyceryl p‐aminobenzoate Isobutyl p‐aminobenzoate Aminolevulinic acid hydrochloride 5‐Aminolevulinic acid; its salts; 27 Hexaminolevulinate hydrochloride its derivatives; their salts Methyl aminolevulinate hydrochloride Denopterin 28 ; its derivatives Methotrexate Para‐Aminosalicylic acid; its Aminosalicylate salts; its derivatives; their salts; p‐Aminosalicylic acid hydrazide 29 any compound with any Benzoylpas substance falling within this Phenyl aminosalicylate item Alfatradiol, Algestone acetophenide, Allyloestrenol, Altrenogest, Androstanolone, Androstenediol, Androstenedione, Benzestrol, Boldenone, Broparestrol, , Chlorotrianisene, Clostebol, Cloxotestosterone, Colpormon, Cyproterone, Danazol, , Demegestone, Desogestrel, Dienoestrol, Dienogest, Diethylstilbestrol, Dimethisterone, Drosprienone, Drostanolone, Dydrogesterone, Elcometrine, Epimestrol, Epitiostanol, Equilin, Estradiol, Estrapronicate, Estriol, Estrone, Estropipate, Ethinyloestradiol, Ethisterone, Ethyloestrenol, Ethynodiol, Etonogestrel, Fluoxymesterone, , Formebolone, Fosfestrol, Furazabol, Gestodene, Gestonorone caproate, Gestrinone, Gestronol, Hexoestrol, Hydroxyestrone diacetate, Hydroxyprogesterone, Androgenic, oestrogenic and 30 Levonorgestrel, Lynoestrenol, Medrogestone, Medroxyprogesterone, progestational substances Megestrol, , Mepitiostane, Mesterolone, MestranolMethandienone, Methandriol, Methandrostenolone, Methenolone, Methyl‐1‐testosterone, Methyltestosterone, MiboleroneMoxestrol, Nandrolone, , Norelgestromin, Norethandrolone, Norethisterone, Norethynodrel, Norgesterone, Norgestimate, Norgestomet, Norgestrel, Norgestrienone, Normethandrone, Norvinisterone, Oestrogen, Oxabolone, Oxandrolone, Oxymesterone, Oxymetholone, Pentagestrone, Polyestradiol, Polyestriol, Prasterone, Progesterone, Proligestone, Promegestone, Promestriene, Quinbolone, Quinestradiol, Quinestrol, Stanolone, Stanozolol, Testolactone, Testosterone, Tetrahydrogestrinone, Tibolone, Tiomesterone, Trenbolone, Trimegestone

26 The Guide Item Entry in the Poisons List or Drugs Covered by the Entry No. Antibiotics Schedule Chloropyramine Chlorothen Dimenhydrinate Histapyrrodine substances: those 31 Mepyramine (Pyrilamine) included in Part I Methapyrilene Niaprazine Thenyldiamine Thonzylamine Alcaftadine, Alimemazine, Azatadine, Bamipine, Bepotastine, Bisulepin, Bromazine (Bromodiphenhydramine), Brompheniramine, Carbinoxamine, Cetirizine, Chlorpheniramine, Cinnarizine, Clemastine, Clemizole, Clocinizine, Cyproheptadine, Deptropine, Dexbrompheniramine, Antihistamine substances: those Dexchlorpheniramine, Dimetindene, Diphenylpyraline, Embramine, 32 included in Part II Emedastine, Epinastine, Flunarizine, Homochlorcyclizine, Latrepirdine, Levocabastine, Levocetirizine, Moxastine, Olopatadine, Oxatomide, Pheniramine, Phenyltoloxamine, Piprinhydrinate, Quifenadine, Rupatadine, Sequifenadine, Setastine, Tolpropamine, Trimethobenzamide, Tripolidine, Tritoqualine Antimony potassium tartrate Antimony, of; organic Antimony sodium gluconate 33 compounds of; antimonates; Meglumine antimonate antimonites Stibocaptate Stibophen Arsenical substances, the following: halides of arsenic; Acetarsol, Arsanilic acid, Arsenamide, Arsthinol, Cacodylate, Carbarsone, organic compounds of arsenic; Melarsoprol, Methanearsonic acid, Monomethylarsinate, 34 oxides of arsenic; sulphides of Neoarsphenamine, Oxophenarsine, Oxophenylarsine, Roxarsone, arsenic; arsenates; arsenites, Sulfaside, Tryparsamide thioarsenates 35 Azauridine; its derivatives Azaribine Azilsartan; its salts; its esters; Azilsartan kamedoxomil 36 their salts Azilsartan medoxomil Benzodepa Carboquone 37 ; its derivatives Diaziquone Meturedepa Uredepa Allobarbital, Amylobarbitone (Amobarbital), Aprobarbital, Barbital Barbituric acid; its salts; its (Barbitone), Brallobarbital, Butabarbital (Secbutabarbital), Butalbital, derivatives; their salts; any Butobarbital, Crotarbital, Cyclobarbital, Cyclopentobarbital, 38 compound with any substance Heptabarbital, Hexobarbital, Methohexital, Methylphenobarbital, falling within this item Pentobarbital, Phenobarbital, Propallylonal, Proxibarbal, Secobarbital (Quinalbarbitone), Talbutal, Thiopentone, Vinbarbital, Vinylbital

27 The Guide Item Entry in the Poisons List or Drugs Covered by the Entry No. Antibiotics Schedule Benztropine and its 39 Ethybenztropine homologues; their salts Biphenylacetic acid; its salts; its 40 Diisopropanolamine felbinac (= Felbinac) esters N‐[4,4‐Bis(para‐ fluorophenyl)butyl]piperidine, 4‐ Penfluridol 41 substituted derivatives of; their Pimozide salts 42 Peplomycin

Albutrepenonacog alfa (recombinant factor IX), Antihaemophilic factor (factor VIII), Efmoroctocog alfa (recombinant factor VIII), Eftrenonacog Blood Products derived from alfa (recombinant factor IX), Eptacog alfa (activated) (recombinant factor 43 human blood or manufactured VIIa), Lonoctocog alfa (recombinant factor VIII), Moroctocog alfa by biotechnology (recombinant factor VIII), Nonacog alfa (recombinant factor IX), Octocog alfa (recombinant factor VIII), Prothrombin, Thromboplastin

44 Bromvaletone (= Bromvalerylurea) ; its salts; its 45 Piretanide derivatives; their salts 46 Bupivacaine; its salts Levobupivacaine Candesartan; its salts; its esters; 47 Candesartan cilexetil their salts Cannabinol and its tetrahydro derivatives; their 3‐alkyl Parahexyl 48 homologues; any ester or Tetrahydrocannabinols of any substance falling within this item Acetylkitasamycin 49 Carbomycin Kitasamycin (Leucomycin) Cefaclor, Cefadroxil, Cefalexin, Cefaloridine, Cefalotin, Cefamandole, Cefapirin, Cefatrizine, Cefazedone, Cefcapene, Cefdinir, Cefditoren, Cefepime, Cefetamet, Cefixime, Cefmenoxime, Cefminox, Cefodizime, 50 Cefonicid, Cefoperazone, Ceforanide, Cefoselis, Cefotaxime, Cefotiam, Cefpimizole, Cefpiramide, Cefpirome, Cefpodoxime, Cefprozil, Cefradine, Cefroxadine, Cefsulodin, Ceftazidime, Ceftibuten, Ceftiofur, Ceftizoxime, Ceftolozane, Ceftriaxone, Latamoxef, Moxalactam Carbocloral Chloral; its addition and its condensation products; any 51 Chloral hydrate compound with any substance Alpha‐Chloralose falling within this item Dichloralphenazone Azidamphenicol 52 Thiamphenicol

28 The Guide Item Entry in the Poisons List or Drugs Covered by the Entry No. Antibiotics Schedule ; its salts; its Amodiaquin 53 derivatives; their salts Hydroxychloroquine and other Althiazide (Altizide), Bemetizide, Bendrofluazide (Bendroflumethiazide), derivatives of benzo‐1, 2, 4‐ Benzthiazide, Benzylhydrochlorothiazide, Buthiazide (Butizide), 54 thiadiazine‐7‐sulphonamide 1, 1‐ Cyclopenthiazide, Cyclothiazide, Epitizide, Flumethiazide, dioxide, whether hydrogenated Hydrochlorothiazide, Hydroflumethiazide, Mebutizide, Methyclothiazide, or not; their salts Polythiazide, Teclothiazide, Trichlormethiazide and other Clopenthixol derivatives of 9‐ 55 Thiothixene methylenethiaxanthen; their Zuclopenthixol salts Azosemide Chloraminophenamide Chlorphenamide Chlorthalidone and other Clopamide 56 derivatives of ortho‐ Dichlorphenamide chlorobenzenesulphonamide Indapamide Tripamide Xipamide 57 ; its salts Escitalopram Clocapramine ; its salts; its 58 Lofepramine derivatives; their salts Mosapramine 59 Colaspase (= L‐Asparaginase) 60 Colistimethate sodium 61 Idarubicin Alprazolam, Bromazepam, Camazepam, Clonazepam, Clorazepate, Diazpeam and other Cloxazolam, Delorazepam, Estazolam, Ethyl loflazepate, Fludiazepam, compounds containing the Flunitrazepam, Flurazepam, Flutoprazepam, Halazepam, Haloxazolam, 62 chemical structure of dihydro‐1, Ketazolam, Loprazolam, Lorazepam, Lormetazepam, Medazepam, 4‐ substituted to Metaclazepam, Midazolam, Nimetazepam, Nitrazepam, Nordazepam, any degree; their salts Oxazepam, Oxazolam, Pinazepam, Prazepam, Quazepam, Temazepam, Tetrazepam, Triazolam Diethyl para‐nitrophenyl 63 (= Paraoxon) phosphate Acetyldigitoxin Acetyldigoxin Deslanoside Digitalis, glycosides of; other Digitalin 64 active principles of digitalis Digitoxin Digoxin Gitoxin Lanatosides

29 The Guide Item Entry in the Poisons List or Drugs Covered by the Entry No. Antibiotics Schedule Dihydrocodeinone‐O‐ 65 carboxymethyloxime; its salts; (= Codoxime) its esters, their salts Dihydrocodeinone enol acetate; 66 (= Acetyldihydrocodeinone, Thebacon) its salts ; its salts; its 67 Diacetyldihydromorphine esters and ethers; their salts 3‐(3,4‐Dihydroxyphenyl); 68 (= Levodopa) its salts Acetylmethadol Dimepheptanol; its salts; its Alphamethadol 69 esters and ethers; their salts Betamethadol (= Methadol, Racemethadol) Dithienylallylamines; Diethylthiambutene 70 dithienylalkylallylamines; their Dimethylthiambutene salts Ethylmethylthiambutene ; its salts; its 71 Cidoxepin derivatives; their salts Azithromycin Clarithromycin 72 Dirithromycin Roxithromycin Telithromycin ; its salts; its 73 Etofenamate esters; their salts Carmofur Doxifluridine 74 ; its derivatives Floxuridine Tegafur 75 Folinic acid; its salts (= Leucovorin) 76 Fusidates Gallamine; its salts; its 77 Gallamine triethiodide quaternary compounds Isepamicin Netilmicin 78 Sisomicin Tobramycin

30 The Guide Item Entry in the Poisons List or Drugs Covered by the Entry No. Antibiotics Schedule Benperidol Bromperidol and other 4‐ Melperone substituted derivatives of N‐(3‐ Moperone 79 para‐fluorobenzoyl‐ Pipamperone propyl)piperidine Spiperone Timiperone Trifluperidol 80 Hexamethylmelamine (= Altretamine) , the following and Benmoxine their ‐methyl derivatives – Isocarboxazid Benzyl ; Phenethyl 81 Phenelzine hydrazine; Phenoxyethyl Pheniprazine hydrazine; their salts; their acyl Phenoxypropazine derivatives; their salts Hydrocyanic acid, cyanides, Cyacetacide 82 other than ferrocyanides and Potassium cyanide ferricyanides Sodium cyanide Hydroxycinchoninic acids; Cinchocaine 83 derivatives of; their salts; their Oxycinchophen esters Hydroxy‐N, N‐ dimethyltryptamines; their Bufotenine 84 esters and ethers; any salt of Psilocin any substance falling within this Psilocybin item 3‐Hydroxy‐N‐methylmorphinan; Levorphanol 85 its salts; its optical isomers; Dextrorphan their salts 3‐Hydroxymorphinan; its salts; its optical isomers; their salts, 86 Norlevorphanol their esters and ethers; their salts 3‐Hydroxy‐N‐ phenacylmorphinan; its salts; its 87 Levophenacylmorphan optical isomers; their salts; their esters and ethers; their salts 88 Pranobex (= Methisopurinol) Glyconiazide ; its salts; its Iproniazid derivatives; their salts; any Methaniazide 89 compound with any substance Pasiniazide falling within this item Salinazid Sulfoniazide

31 The Guide Item Entry in the Poisons List or Drugs Covered by the Entry No. Antibiotics Schedule Amikacin Arbekacin 90 Kanamycin Bekanamycin Dibekacin 91 ; its salts Esketamine 92 Clindamycin Melagatran; its salts; its 93 Ximelagatran derivatives; their salts Azathioprine ; its salts; its 94 Thiamiprine derivatives; their salts Thioguanine Mercury, nitrates of; organic compounds of; oxides of; mercuric ammonium ; Hydrargaphen 95 mercuric chloride; mercuric Merbromin (Mercurochrome) iodide; mercuric oxycyanide; mercuric thiocyanate; potassiomercuric iodides ; its salts; its optical 96 Dextromethorphan isomers; their salts 97 Methylaminoheptane; its salts (= Octodrine) 2‐Methyl‐3‐morpholino‐1, 1‐ 98 diphenylpropanecarboxylic acid; (= Moramide intermediate) its salts; its esters; their salts

99 ; its derivatives (= Meparfynol)

32 The Guide Item Entry in the Poisons List or Drugs Covered by the Entry No. Antibiotics Schedule Alpha‐Methylphenethylamine; beta‐methylphenethylamine; alpha‐ethylphenethylamine; beta‐ethylphenethylamine; their optical isomers; any synthetic compound structurally derived from any of those substances by substitution in the aliphatic part or by ring Amfepramone (Diethylpropion), Benfluorex, Benzphetamine, Cafedrine, closure therein (or by both such Ethylamphetamine, Fenethylline, Fenproporex, Gepefrine, Mebeverine, 100 substitution and such closure) Mephentermine, Methamphetamine, Pentorex, Phendimetrazine, or by substitution in the Phenmetrazine, Phentermine, Phenylpropanolamine, Pipradrol, aromatic ring (with or without Prenylamine, Selegiline (Deprenyl), Tamsulosin substitution at the atom), except hydroxyamphetamine, , and N‐substituted derivatives of ephedrine; any salt of any substance falling within this item 1‐Methyl‐4‐phenylpiperidine‐4‐ Pethidine 101 carbox ylic acid; its salts; its Properidine esters; their salts Moxidectin 102 Milbemycins Selamectin Bendamustine, Canfosfamide, Chlorambucil, Chlornaphazine, Mustine and other N‐ Cyclophosphamide, Defosfamide, Estramustine, Melphalan, 103 substituted derivative of di‐(2‐ Perfosfamide, Prednimustine, Trichlormethine, Trofosfamide, chloroethyl)amine; their salts Uramustine ; its salts; its 104 Mycophenolate mofetil esters Noramidopyrine 105 Dipyrone methanesulphonate; its salts 106 ; its salts; its esters Levofloxacin 107 Troleandomycin Carbetocin 108 Cargutocin Demoxytocin

33 The Guide Item Entry in the Poisons List or Drugs Covered by the Entry No. Antibiotics Schedule Amoxicillin, Ampicillin, Aztreonam, Bacampicillin, Benzathine Benzylpenicillin, Benzylpenicillin (Penicillin G), Carbenicillin, Carfecillin, Carindacillin, Cloxacillin, Dicloxacillin, Epicillin, Ertapenem, Flucloxacillin, 109 Penicillin Imipenem, Mecillinam, Metampicillin, Methicillin sodium, Mezlocillin, Oxacillin, Phenoxymethylpenicillin (Penicillin V), Piperacillin, Pivampicillin, Pivmecillinam, Procaine Penicillin, Sulbenicillin, Sultamicillin, Ticarcillin 110 Pentaerythritol tetranitrate (= Nitropentaerythritol) Perindoprilat; its salts; its 111 Perindopril esters; their salts Acepromazine, Aceprometazine, Acetophenazine, Aminopromazine, Azaclorzine, Butaperazine, Carfenazine (Carphenazine), ; its salts; its Chlorproethazine, Chlorpromazine, Combelen (Propionylpromazine), derivatives (except Cyamemazine, Diethazine, Dixyrazine, Ethacizine, Fluphenazine, dimethoxanate); their salts Homofenazine, Hydroxyethylpromethazine, Mequitazine, Mesoridazine, 112 (except salts of dimethoxanate); Methotrimeprazine (Levomepromazine), Metopimazine, Oxomemazine, any compound with any Parathiazine, Perazine, Pericyazine, Perimethazine, Perphenazine, substance falling within this Piperacetazine, Pipothiazine, Prochlorperazine, Profenamine, Promazine, item Propiomazine, Sulforidazine, Thiazinamium methylsulfate, Thiethylperazine, Thiopropazate, Thioproperazine, Thioridazine, Trifluomeprazine, Trifluoperazine, Triflupromazine Pyrazinobutazone 113 ; its salts Thiazolinobutazone 2‐Phenylcinchoninic acid; 2‐ 114 salicylcinchoninic acid; their (2‐Phenylcinchoninic acid = Cinchophen) salts; their esters Ethotoin Mephenytoin 5‐Phenylhydantoin; its alkyl and 115 Methetoin aryl derivatives; their salts 3‐Methyl‐5‐phenylhydantoin Phenytoin Follicle‐stimulating hormone (FSH, Follitropin), Follitropin alfa, Follitropin , the active beta, Follitropin delta, Luteinizing hormone (LH), Lutropin alfa, principles of, other than 116 Menotropin, Prolactin, Somatotropin, Somatrem, Somatropin (Human corticotrophins, oxytocins and growth hormone), Thyroid‐stimulating hormone (TSH, Thyrotropin), Urofollitropin Tiamulin 117 Valnemulin Decamethonium bromide Polymethylenebistrimethylamm 118 Hexamethonium onium salts Pentamethonium bromide Dalfopristin 119 Quinupristin Propoxyphene; its salts; its 120 Dextropropoxyphene optical isomers; their salts

34 The Guide Item Entry in the Poisons List or Drugs Covered by the Entry No. Antibiotics Schedule Levobunolol ; its salts; its 121 Nadoxolol derivatives; their salts Naftopidil , the following and their derivatives – Alprostadil; ; Dinoprost; Dinoprostone; Carboprost, Cloprostenol, Enprostil, Fenprostalene, Gemeprost, 122 Epoprostenol; ; Limaprost, Ornoprostil, Rioprostil, Sulprostone, Trimoprostil ; ; ; their salts; their esters Amitriptylinoxide ; its salts; its 123 Butriptyline derivatives; their salts ; its salts; its derivatives; Hydroquinine 124 their salts Quinidine Epoetin alfa Epoetin Beta Epoetin Delta Epoetin Gamma Recombinant Human 125 Epoetin Kappa Epoetin Lambda Epoetin Omega Epoetin Theta Epoetin Zeta Rifabutin Rifampicin 126 Rifapentine Rifaximin Tilmicosin 127 Tylosin 128 Dihydrostreptomycin Cymarin 129 Strophanthus, glycosides of Ouabain Strophanthin 130 Sulphonal; alkyl sulphonals Sulfonethylmethane

35 The Guide Item Entry in the Poisons List or Drugs Covered by the Entry No. Antibiotics Schedule Acetoxypregnenolone, Adrenaline (Epinephrine), Alclometasone, Aldosterone, Algestone, Amcinonide, Arbutamine, Beclomethasone, Betamethasone, Budesonide, Chloroprednisone, Ciclesonide, Clobetasol, Clobetasone, Clocortolone, Cloprednol, Cortisone, Cortivazol, Deflazacort, Deoxycorticosterone, Desonide, Desoxymethasone, Dexamethasone, Dichlorisone, Diflorasone, Diflucortolone, Difluprednate, Dimetofrine, Dipivefrin, Etiprednol dicloacetate, Flucinolone, Flucinonide, Flucloronide, Fludrocortisone, Flumethasone, Suprarenal gland, the active Flunisolide, , Fluocortolone, Fluorometholone, 131 principles of; their salts; their , , Fluprednisolone, derivatives; their salts Flurandrenolide, Fluticasone, Fluzacort Formocortal, Halcinonide, Halobetasol, Halometasone, Halopredone acetate, Hexoprenaline, Hydrocortamate, Hydrocortisone, Isoflupredone, Isoproterenol, Loteprednol etabonate, Mazipredone, Medrysone, Meprednisone, Methyladrenaline, Methylprednisolone, Mometasone, Noradrenaline, Nordefrin, Paramethasone, Prednicarbate, Prednisolamate, Prednisolone, Prednisone, Prednival, Prednylidene, Pregnenolone, Rimexolone, Tixocortol, Triamcinolone Tenofovir; its salts; its Tenofovir Alafenamide 132 derivatives; their salts Tenofovir Disoproxil Demeclocycline Doxycycline Lymecycline Meclocycline 133 Tetracycline Methacycline Minocycline Rolitetracycline Tigecycline 134 ; its salts (= Alpha‐Lipoic acid) Thioctic acid; its salts; its Ethylenediamine thioctate 135 derivatives; when contained in Sodium thioctate pharmaceutical products Thioctic acid amide (Thioctamide) Trometamol thioctate Calcitonin Elcatonin Thyroid gland, the active 136 Liothyronine (T3, Triiodothyronine) principles of; their salts Salcatonin Thyroxine (T4) 2, 2, 2‐Trichloroethyl , Trichlorourethan 137 esters of; their salts Triclofos ; its salts; its 138 Alatrofloxacin derivatives; their salts Gramicidin 139 Tyrocidine

36 The Guide Item Entry in the Poisons List or Drugs Covered by the Entry No. Antibiotics Schedule Divalproex sodium 140 Valproic acid; its salts; its esters Valproate 141 Teicoplanin Desmopressin Felypressin 142 Lypressin Ornipressin Terlipressin 143 Mikamycin

37