“2-Aminoisoheptane” and “Aconitum Kusnezoffii.”

EXPOSING HARMFUL INGREDIENTS IN DIETARY SUPPLEMENTS

Unapproved stimulants found in products containing “2-aminoisoheptane” and “Aconitum kusnezof i.”

ILLEGAL INGREDIENTS UNAPPROVED INGREDIENTS

DMAA DMBA 1,4-DMAA Octodrine 2 AMINOISOHEPTANE A. KUSNEZOFFII PHARMACOLOGIC EFFECTS SIMILAR TO DMAA AND EPHEDRINE

Researchers at NSF International recently identi ed unlabeled DMAA-like stimulants in over-the-counter weight-loss and pre-workout products currently available worldwide.1 Products Tested 2013 2013 Product Manufacturer Unapproved Compounds Game Day MAN Sports Octodrine DMAA DEPEA

Infrared Gold Star 1,3-DMAA* 2-aminoisoheptane Chaos and Pain 1,4-DMAA 2014 2016 1,3-DMAA* Simply Skinny Pollen Bee Fit with Trish 1,4-DMAA DMBA Oxilofrine

Cannibal Ferox AMPED Chaos and Pain 1,3-DMBA*

Triple X Gold Star 1,4-DMAA NOT THE FIRST TIME: NSF researchers have *Previously found to be unlawful dietary ingredient by the U.S. FDA found potentially harmful compounds in supplements on four occasions. HIDDEN STIMULANTS: WHAT ARE THE RISKS? High-Risk Categories of Supplements6 DEPEA – Risk of heart attack.2

DMAA – Elevated blood pressure and cardiovascular problems.3 Muscle Pre-workout Weight loss Sexual building performance DMBA – Risk of heart attacks, seizures and neurological conditions.4

Oxilofrine – Nausea and vomiting, tachycardia, chest pain and cardiac arrest.5

CARDIOVASCULAR RISKS INCREASE WHEN PRODUCTS COMBINED WITH CAFFEINE OR EXERCISE.

DISGUISING HARMFUL INGREDIENTS 2-aminoisoheptane “2-aminoisoheptane” and “Aconitum kusnezoffii” appear to be new disguises for illegal and unapproved synthetic stimulants.1

Aconitum NSF’s research team sees no evidence kusnezoffii that 2-aminoisoheptane is a legitimate dietary ingredient derived from plants.1

DMAA Octodrine

A New DMAA Analog

1,4-DMAA appears to be a novel compound never tested on humans. This newly identified DMBA compound is similar to the stimulant DMAA. 1,4-DMAA

HOW TO CHOOSE SAFER DIETARY SUPPLEMENTS

Look for the Avoid products NSF mark containing on certi ed “2-aminoisoheptane” dietary or “ Aconitum supplements kusnezof i”

NSF-CERTIFIED PRODUCTS ARE:

Tested to verify product formulation and label claims.

Tested for harmful levels of specific contaminants and fraudulent ingredients.

Produced in manufacturing facilities that are inspected twice a year to comply with U.S. FDA Good Manufacturing Practices (GMPs).

1 Four experimental stimulants found in sports and weight-loss supplements: 2-amino-6-methylheptane (octodrine), 1,4-dimethylamylamine (1,4-DMAA), 1,3-dimethylamylamine (1,3-DMAA) and 1,3-dimethylbutylamine (1,3-DMBA). Clinical Toxicology. www.tandfonline.com/doi/full/10.1080/15563650.2017.1398328.

2 Potentially Harmful Adulterant Called N,alpha-diethylphenylethylamine (N,a-DEPEA) Found in a Dietary Supplement. NSF International website. www.nsf.org/newsroom/emerging-and-potentially-harmful-adulterant-depea-found-in-supplements. Accessed June 5, 2017.

3 DMAA in Dietary Supplements. U.S. Food and Drug Administration website. www.fda.gov/food/dietarysupplements/productsingredients/ucm346576.htm. Accessed June 5, 2017.

4 DMBA in Dietary Supplements. U.S. Food and Drug Administration website. www.fda.gov/food/dietarysupplements/productsingredients/ucm444719.htm. Accessed June 5, 2017.

5 Scientists at NSF International say oxilofrine could be disguised or unlisted on the label and pose serious health risks to consumers. NSF International website. www.nsf.org/newsroom/unapproved-ephedrine-like-stimulant-oxilofrine-found-in-14-dietary-suppleme. Accessed June 5, 2017.

6 Supplements and Health: Sorting the Facts. Harvard T.H. Chan School of Public Health website. https://theforum.sph.harvard.edu/events/supplements-and-health. Accessed June 5, 2017.