Current Awareness in Clinical Toxicology Editors: Damian Ballam MSc and Allister Vale MD

November 2017

CONTENTS General Toxicology 11 Metals 50 Management 24 52 27 Chemical Warfare 54 Chemical Incidents & 40 Plants 55 Pollution Chemicals 40 56

CURRENT AWARENESS PAPERS OF THE MONTH

Rethinking mercury: the role of selenium in the pathophysiology of mercury toxicity Spiller HA. Clin Toxicol 2017; online early: doi: 10.1080/15563650.2017.1400555: Introduction There is increasing evidence that the pathophysiological target of mercury is in fact selenium, rather than the covalent binding of mercury to sulfur in the body's ubiquitous sulfhydryl groups. The role of selenium in mercury poisoning is multifaceted, bidirectional, and central to understanding the target organ toxicity of mercury. Methods An initial search was performed using Medline/PubMed, Toxline, Google Scholar, and Google for published work on mercury and selenium. These searches yielded 2018 citations. Publications that did not evaluate selenium status or evaluated environmental status (e.g., lake or ocean sediment) were excluded, leaving approximately 500 citations. This initial selection was scrutinized carefully and 117 of the most relevant and representative references were selected for use in this review.

Current Awareness in Clinical Toxicology is produced monthly for the American Academy of Clinical Toxicology by the Birmingham Unit of the UK National Poisons Information Service, with contributions from the Cardiff, Edinburgh, and Newcastle Units.

The NPIS is commissioned by Public Health England

2

Binding of mercury to thiol/sulfhydryl groups Mercury has a lower affinity for thiol groups and higher affinity for selenium containing groups by several orders of magnitude, allowing for binding in a multifaceted way. The established binding of mercury to thiol moieties appears to primarily involve the transport across membranes, tissue distribution, and enhanced excretion, but does not explain the oxidative stress, calcium dyshomeostasis, or specific organ injury seen with mercury. Effects of mercury on selenium and the role this plays in the pathophysiology of mercury toxicity Mercury impairs control of intracellular redox homeostasis with subsequent increased intracellular oxidative stress. Recent work has provided convincing evidence that the primary cellular targets are the selenoproteins of the thioredoxin system (thioredoxin reductase 1 and thioredoxin reductase 2) and the glutathione-glutaredoxin system (glutathione peroxidase). Mercury binds to the selenium site on these proteins and permanently inhibits their function, disrupting the intracellular redox environment. A number of other important possible target selenoproteins have been identified, including selenoprotein P, K, and T. Impairment of the thioredoxin and glutaredoxin systems allows for proliferation intracellular reactive oxygen species which leads to glutamate excitosis, calcium dyshomeostasis, mitochondrial injury/loss, lipid peroxidation, impairment of protein repair, and apoptosis. Methylmercury is a more potent inhibitor of the thioredoxin system, partially explaining its increased . A second important mechanism is due to the high affinity of mercury for selenium and the subsequent depletion of selenium stores needed for insertion into de novo generation of replacement selenoproteins. This mercury-induced selenium deficiency state inhibits regeneration of the selenoproteins to restore the cellular redox environment. The effects of selenium on mercury and the role this plays in biological response to mercury Early research suggested selenium may provide a protective role in mercury poisoning, and with limitations this is true. The roles selenium plays in this reduction of mercury toxicity partially depends on the form of mercury and may be multifaceted including: 1) facilitating demethylation of organic mercury to inorganic mercury; 2) redistribution of mercury to less sensitive target organs; 3) binding to inorganic mercury and forming an insoluble, stable and inert Hg:Se complex; 4) reduction of mercury absorption from the GI tract; 5) repletion of selenium stores (reverse selenium deficiency); and 6) restoration of target selenoprotein activity and restoring the intracellular redox environment. There is conflicting evidence as to whether selenium increases or hinders mercury elimination, but increased mercury elimination does not appear to be a major role of selenium. Selenium supplementation has been shown to restore selenoprotein function and reduce the toxicity of mercury, with several significant limitations including: the form of mercury (methylmercury toxicity is less responsive to amelioration) and mercury dose. Conclusions The interaction with selenium is a central feature in mercury toxicity. This interaction is complex depending on a number of features such as the form of mercury, the form of selenium, the organ and dose. The previously suggested "protective effect" of selenium against mercury toxicity may in fact be backwards. The effect of mercury is to produce a selenium deficiency state and a direct inhibition of selenium's role in controlling the intracellular redox environment in organisms. Selenium supplementation, with limitations, may have a beneficial role in restoring adequate selenium status from the deficiency state and mitigating the toxicity of mercury.

Full text available from: http://dx.doi.org/10.1080/15563650.2017.1400555

3

The safety of high-dose insulin euglycaemia therapy in - induced cardiac toxicity Page CB, Ryan NM, Isbister GK. Clin Toxicol 2017; online early: doi: 10.1080/15563650.2017.1391391: Context High-dose insulin euglycaemia (HIE) is recommended in the management of toxin-induced cardiac toxicity, with increasing insulin doses now being used. We aimed to investigate the safety of HIE in toxin-induced cardiac toxicity. Methods This was a retrospective review of cases from two clinical toxicology units. Demographics, toxin(s) ingested, clinical effects, investigations (serum glucose, electrolytes), treatments (insulin, glucose, electrolyte replacement), length of stay (LOS) and outcomes were extracted from the patients' medical records. Associations between insulin and glucose/electrolyte homeostasis were explored by comparing insulin administration and glucose or electrolyte concentrations and replacement. Results There were 22 patients (12 females), median age 57 years (15–88 years) treated with HIE. There were 12 beta-blocker, six calcium channel blocker and three combined beta-blocker and calcium channel blocker ingestions. A total of 19 patients had a systolic blood pressure <80mmHg and 18 patients required inotropes in addition to HIE. There were three deaths. Despite glucose and electrolyte replacement, 16 patients (73%) developed hypoglycaemia (Reference range [RR] <3.5 mmol/L or <63 mg/dl). In 7 patients, hypoglycaemia was mild (2.5–3.4 mmol/L or 45–62 mg/dl) and in nine was severe (<2.5 mmol/L or <45 mg/dl). There were no neurological effects from hypoglycaemia. A total of 18 patients (82%) developed hypokalaemia (<3.5 mEq/L). In 16 patients, this was mild (2.5-3.4 mEq/L). There were no cardiac arrhythmias associated with this hypokalaemia.There was no apparent association between insulin dosing and severity of hypoglycaemia or hypokalaemia, or in glucose or potassium replacement. Median insulin loading dose was 80U (range 50–125 U) and the median maximum insulin infusion rate was 150 U/h (range 38–1500 U/h). Median glucose infusions rates were 37.5g/h (range 4–75g/h). There was no apparent association between insulin and glucose administration. Glucose was administered for a median of 18h after ceasing insulin. The duration of glucose administration after ceasing insulin increased with the rate and total insulin administered during HIE. Discussion Despite the benefits of HIE in toxin-induced cardiac toxicity, it caused significant disruption to glucose and electrolyte homeostasis, although there were no apparent complications from this. There was no association by comparing the amount of insulin administered on adverse effects or glucose administered, suggesting higher doses of insulin are associated with no more adverse effects.

Full text available from: http://dx.doi.org/10.1080/15563650.2017.1391391

4

Reductions in emergency department visits after primary healthcare use of the UK National Poisons Information Service Elamin MEMO, James DA, Holmes P, Jackson G, Thompson JP, Sandilands EA, Bradberry S, Thomas SHL. Clin Toxicol 2017; online early: doi: 10.1080/15563650.2017.1390120: Background Suspected poisoning is a common cause of hospital admission internationally. In the United Kingdom, the National Poisons Information Service (NPIS), a network of four poisons units, provides specialist advice to health professionals on the management of poisoning by telephone and via its online poisoning information and management database, TOXBASE®. Objective To demonstrate the impact of NPIS telephone advice and TOXBASE® guidance on poisoning- related referrals to emergency departments (ED) from primary healthcare settings. Methods A telephone survey of primary healthcare providers calling the NPIS and an online survey of TOXBASE® primary care users were conducted to evaluate the effect of these services on poisoning-related ED referrals. Enquirers were asked to indicate whether referral was needed before and after using these information sources. Results The number of cases considered by enquirers appropriate for ED referral was reduced from 1178 (58.1%) before to 819 (40.4%) after the provision of telephone advice for 2028 cases (absolute reduction 17.7%, 95% CI 14.6, 20.7%) and from 410 (48.2%) before to 341 (40.1%) after consideration of TOXBASE® guidance for 851 cases (absolute reduction 8.1%, 95% CI 3.3, 12.9%). By extrapolating these figures over a full year, it is estimated that these services prevent approximately 41,000 ED referrals annually. Conclusions The use of NPIS services significantly reduced ED referrals from primary healthcare services with resulting avoided healthcare costs exceeding the current annual NPIS budget. Further studies are needed to evaluate other potential benefits of accessing NPIS services.

Full text available from: http://dx.doi.org/10.1080/15563650.2017.1390120

High-dose immunosuppression to prevent death after paraquat self-poisoning – a randomised controlled trial Gawarammana I, Buckley NA, Mohamed F, Naser K, Jeganathan K, Ariyananada PL, Wunnapuk K, Dobbins TA, Tomenson JA, Wilks MF, Eddleston M, Dawson AH. Clin Toxicol 2017; online early: doi: 10.1080/15563650.2017.1394465: Context Intentional self-poisoning with the herbicide paraquat has a very high case-fatality and is a major problem in rural Asia and Pacific. Objectives We aimed to determine whether the addition of immunosuppression to supportive care offers benefit in resource poor Asian district hospitals. Materials and methods We performed a randomised placebo-controlled trial comparing immunosuppression (intravenous cyclophosphamide up to 1 g/day for two days and methylprednisolone 1 g/day for three days, and then oral dexamethasone 8 mg three-times-a-day for 14 days) with

5

saline and placebo tablets, in addition to standard care, in patients with acute paraquat self- poisoning admitted to six Sri Lankan hospitals between 1st March 2007 and 15th November 2010. The primary outcome was in-hospital mortality. Results 299 patients were randomised to receive immunosuppression (147) or saline/placebo (152). There was no significant difference in in-hospital mortality rates between the groups (immunosuppression 78 [53%] . placebo 94 [62%] (Chi squared test 2.4, p = .12). There was no difference in mortality at three months between the immunosuppression (101/147 [69%]) and placebo groups (108/152 [71%]); (mortality reduction 2%, 95% CI: -8 to +12%). A Cox model did not support benefit from high-dose immunosuppression but suggested potential benefit from the subsequent two weeks of dexamethasone. Conclusions We found no evidence that high dose immunosuppression improves survival in paraquat- poisoned patients. The continuing high mortality means further research on the use of dexamethasone and other potential treatments is urgently needed.

Full text available from: http://dx.doi.org/10.1080/15563650.2017.1394465

2-Methyl-4-chlorophenoxyacetic acid (MCPA) and bromoxynil herbicide ingestion Chiew AL, Page CB, Clancy D, Mostafa A, Roberts MS, Isbister GK. Clin Toxicol 2017; online early: doi: 10.1080/15563650.2017.1385790: Context Ingestion of bromoxynil and 2-methyl-4-chlorophenoxyacetic acid (MCPA) in combination is associated with high mortality. Toxicity is characterised by hyperthermia and metabolic acidosis. Dialysis is a proposed treatment, but little data exist regarding its effectiveness. Case details Case 1: A 50-year-old f emale presented 18 h post-ingestion of 200 mL of bromoxynil (200 g/L) and MCPA(200 g/L). She was agitated, tachycardic and tachypnoeic. She was intubated and continuous venovenous haemodiafiltration (CVVHDF) was commenced. She deteriorated, becoming hypotensive, hyperthermic (39.5 °C) and hypercapnic (80 mmHg). She was cooled, paralysed, received CVVHDF for 2d and was extubated on day 4 making a full recovery. Case 2: A 60-year-old male presented 6 h post-ingestion of an unknown amount of bromoxynil (200 g/L) and MCPA (200 g/L). On arrival, he was tachycardic and tachypneic (pCO2 25 mmHg). At 8h post-ingestion he became hyperthermic, hypercapnic and acidotic (pH 7.15), and was intubated, paralysed, cooled and received CVVHDF for 36 h. He was extubated after 42 h and made a full recovery. Bromoxynil and MCPA serum and effluent concentrations were measured. Peak MCPA serum concentrations were 161 µg/ml and 259 µg/ml and peak bromoxynil concentrations were 119 µg/ml and 155 µg/ml in case 1 and 2, respectively. The estimated clearance of both herbicides by CVVHDF was low (<10 mL/min). CVVHDF did not result in significant clearance of either herbicide but may have assisted with hyperthermia control. Both patients survived with vigorous cooling, paralysis and ventilatory support.

Full text available from: http://dx.doi.org/10.1080/15563650.2017.1385790

6

Serum N-terminal proBNP, not troponin I, at presentation predicts long-term neurologic outcome in acute charcoal- burning carbon monoxide intoxication Moon JM, Chun BJ, Shin MH, Lee SD. Clin Toxicol 2017; online early: doi: 10.1080/15563650.2017.1394464: Objective This study aimed to investigate whether the serum N-terminal pro-brain natriuretic peptide (NT-proBNP) and troponin I levels at emergency department (ED) presentation predict long- term neurologic outcomes after acute charcoal-burning carbon monoxide (CO) poisoning. Methods This retrospective study included 220 patients suffering from charcoal-burning CO poisoning. The demographics, serum NT-proBNP and troponin I levels at ED presentation, treatment, clinical course during hospitalization, and long-term neurologic outcomes were collected. Results The median serum NT-proBNP level at presentation was 48.8 (16.5–259) pg/mL, and 78 patients (35.5%) had elevated troponin I (>0.04 ng/mL) after acute charcoal-burning CO poisoning. The upper NT-proBNP and elevated troponin I groups had higher prevalences of respiratory failure, hypotension, and myocardial injury during hospitalization and altered mentality (GCS 14) at discharge than the lower NT-proBNP and normal troponin I groups. The incidence of persistent severe neurologic sequelae at 25 months after acute CO poisoning was 10.9%. The upper NT-proBNP and elevated troponin I groups had a higher incidence of poor long-term neurologic outcome than the counterpart groups. Log- transformed NT-proBNP and elevated troponin I were associated with poor long-term neurologic outcome in the univariate analysis, but only the adjusted log-transformed NT- proBNP remained an independent factor in the multivariate analysis. Compared with a predictive model including previously proposed predictors, the addition of log NT-proBNP improved the diagnostic accuracy for predicting poor long-term neurologic outcome. The serum NT-proBNP values for predicting poor long-term neurologic outcome were 74.6 and 32.7 pg/mL at fixed sensitivities of 95 and 99%, respectively. Conclusions Elevated serum NT-proBNP at ED presentation is correlated with a risk of poor long-term neurologic outcome after discharge in cases of acute charcoal-burning CO poisoning. NT- proBNP could significantly improve the risk stratification of patients who will experience poor long-term neurologic outcome after CO poisoning. This potentially valuable marker should be further validated.

Full text available from: http://dx.doi.org/10.1080/15563650.2017.1394464

Envenomation by the noble false widow Steatoda nobilis (Thorell, 1875) – five new cases of steatodism from Ireland and Great Britain Dunbar JP, Afoullouss S, Sulpice R, Dugon MM. Clin Toxicol 2017; online early: doi: 10.1080/15563650.2017.1393084: Objective The noble false widow Steatoda nobilis is the only medically significant spider known to occur in the British Isles and Ireland, with a single case of steatodism ever reported from Great Britain. We present here five new cases of envenomations by S. nobilis, three from Ireland and two from Great Britain and describe symptoms not previously reported for the

7

genus Steatoda. Case presentation Four adult males and one adult female with confirmed S. nobilis bites reported their symptoms to the authors. General practitioner chart was obtained for case #3. In all five cases, envenomations were immediately followed by a sharp and prolonged onset of pain, mild to extensive erythema and localised to extensive swelling around the bite site. Additional symptoms include moderate to intense pruritus, vasodilation of the capillaries around the bite site and a possible minor necrotic wound. Conclusion In all cases, symptoms subsided within 48–72 h and no further complications were reported. Envenomations by S. nobilis seem to produce symptoms similar (but not identical) to those previously reported from other Steatoda sp. Considering their benign outcome, envenomations by S. nobilis should still be regarded as of moderate medical importance, requiring monitoring and pain management strategies.

Full text available from: http://dx.doi.org/10.1080/15563650.2017.1393084

Sources, symptoms and characteristics of childhood lead poisoning: experience from a lead specialty clinic in China Ying X, Gao Z-Y, Yan J, Zhang M, Wang J, Xu J, Markowitz M, Yan C-H. Clin Toxicol 2017; online early: doi: 10.1080/15563650.2017.1391392: Objectives This study explored the sources of lead exposure, identified patients' geographic distribution and evaluated the symptoms of children with elevated blood lead levels (BLLs) referred to a pediatric lead specialty clinic in China. Material and methods Data were collected from 515 consecutive outpatients attending the Pediatric Lead Poisoning Clinic in Xinhua Hospital, Shanghai, China, between 2011 and 2016, referred for BLLs 5 g/dL. Atomic absorption spectrometry was used to measure venous BLLs. Results The mean ± standard deviation age of the patients was 4.1 ± 3.2 years. Their BLLs ranged from 5 to 126 g/dL. The geometric mean and median BLLs were 24 and 26 g/dL, respectively. Two hundred and twenty-two children (43.1%) were exposed to industrial lead pollution–mainly from Zhejiang, Jiangsu, Hunan, Henan and Anhui provinces; whereas, 41.4% (213 cases) were induced by folk medicines used widely throughout China. Other nonindustrial sources of lead exposure included lead-containing tinfoil and tin pots. Household lead paint was a rare source. Most patients exhibited nonspecific symptoms, such as hyperactivity, attention difficulty, aggressiveness, constipation and anorexia. Conclusions Industrial pollution and folk medicines are important sources of lead exposure in China. Childhood lead poisoning may be difficult to diagnose clinically as symptoms are nonspecific. Thus, blood lead screening may be necessary to identify children at high risk of exposure. Education to raise the awareness of potential sources of exposure resulting in their elimination would be expected to decrease the incidence of children with elevated BLLs.

Full text available from: http://dx.doi.org/10.1080/15563650.2017.1391392

8

Four experimental found in sports and weight loss supplements: 2-amino-6-methylheptane (octodrine), 1,4- dimethylamylamine (1,4-DMAA), 1,3-dimethylamylamine (1,3- DMAA) and 1,3-dimethylbutylamine (1,3-DMBA) Cohen PA, Travis JC, Keizers PHJ, Deuster P, Venhuis BJ. Clin Toxicol 2017; online early: doi: 10.1080/15563650.2017.1398328: Background The United States Food and Administration banned the 1,3- dimethylamylamine (1,3-DMAA) from dietary supplements and warned consumers that the stimulant can pose cardiovascular risks ranging from high blood pressure to heart attacks. Objectives We designed our study to determine if a new stimulant similar in structure to 1,3-DMAA has been introduced as an ingredient in supplements sold in the United States (US). Methods We analyzed six brands of supplements that listed an ingredient on the label (e.g., Aconitum kusnezoffii, DMHA or 2-amino-isoheptane) that might refer to an analog of 1,3-DMAA. Supplements were analyzed by two separate laboratories using ultra-high-performance liquid chromatography mass spectrometry and reference standards. Results Two previously unidentified 1,3-DMAA analogs (2-amino-6-methylheptane [octodrine] and 1,4-dimethylamylamine [1,4-DMAA]) and two banned stimulants (1,3-DMAA and 1,3- dimethylbutylamine [1,3-DMBA]) were identified. Octodrine was found at a dose (±95% CI) of 72 ± 7.5 mg per serving. In Europe, octodrine was previously sold as a pharmaceutical in multi-ingredient at dosages from 8 to 33 mg. The quantity of octodrine found in our study was more than twice the largest pharmaceutical dose. The other new stimulant, 1,4-DMAA, has not previously been approved for human consumption, and its safety in humans is unknown. 1,4-DMAA was found at dosages between 21 ± 11 mg to 94 ± 48 mg per serving. In addition, two banned stimulants – 1,3-DMAA and 1,3-DMBA – were also identified: 24 ± 7.6 mg to 35 ± 11 mg of 1,3-DMAA and 51 ± 16 mg of 1,3-DMBA. In one product, 24 ± 7.6 mg of 1,3-DMAA was combined with 21 ± 11 mg of 1,4-DMAA. 1,3-DMAA has been investigated as potentially contributing to hemorrhagic strokes and sudden death, whereas the safety of 1,3-DMBA in humans is unknown. Conclusion Two banned stimulants (1,3-DMAA and 1,3-DMBA) and two previously unidentified stimulants (1,4-DMAA and octodrine) were identified in supplements sold in the United States.

Full text available from: http://dx.doi.org/10.1080/15563650.2017.1398328

Acute side effects after consumption of the new synthetic cannabinoids AB-CHMINACA and MDMB-CHMICA Hermanns-Clausen M, Müller D, Kithinji J, Angerer V, Franz F, Eyer F, Neurath H, Liebetrau G, Auwärter V. Clin Toxicol 2017; online early: doi: 10.1080/15563650.2017.1393082: Introduction In 2014, the "European Monitoring Centre for Drugs and Drug Addiction" (EMCDDA) reported on 30 novel synthetic cannabinoids (SCs). Among these were indole- and indazole- based valine derivatives with a cyclohexylmethyl side chain (e.g., AB-CHMINACA and MDMB-

9

CHMICA), which represent a new class of SCs. Methods A prospective observational study of patients treated in emergency departments (EDs) after the intake of SCs was conducted. Clinical and laboratory data were combined and reported to a poison control centre. Serum and/or urine samples of ED patients were analyzed using LC-MS/MS. Results Forty four patients (39 male, five female, 12–48 years) were included. AB-CHMINACA (MDMB-CHMICA) was identified in 20 (19) serum samples, and in 21 (25) urine samples, respectively. In 19 of the cases, more than one SC was present. Other psychoactive substances (mainly amfetamines) were identified in seven cases, but in five out of these in urine samples only. Based on the Poison Severity Score, severity of poisoning was minor (4), moderate (31) or severe (9). Most frequently reported neuropsychiatric symptoms were CNS-depression (n = 21, 61%), disorientation (n = 20, 45%), generalized seizures (n = 12, 27%), combativeness (n = 8, 18%) and extreme agitation (n = 7, 16%). Duration of symptoms lasting 24 hours or longer occurred in 15 cases (34%). Discussion The prevalence of certain neuropsychiatric symptoms was higher in our study than in former reports after the intake of SCs of the aminoalkylindole-type (first generation) SCs. In addition, severe poisoning and duration of symptoms were also higher. Conclusions In this study, the valine derivative AB-CHMINACA and the tert-leucine derivative MDMB- CHMICA ("third generation of SCs") seem to be associated with more severe clinical toxicity than was previously reported in patients exposed to earlier generation SCs such as JWH- 018. However, this observation needs to be confirmed with a larger cohort of patients with analytically confirmed abuse of third generation SCs. The rapid turnover of SCs on the drug market together with the occurrence of SCs such as AB-CHMINACA and MDMB-CHMICA is alarming, especially because of the unexpectedly high frequency of neuropsychiatric symptoms.

Full text available from: http://dx.doi.org/10.1080/15563650.2017.1393082

Human toxicity caused by indole and indazole carboxylate synthetic cannabinoid receptor agonists: from horizon scanning to notification Hill SL, Dunn M, Cano C, Harnor SJ, Hardcastle IR, Grundlingh J, Dargan PI, Wood DM, Tucker S, Bartram T, Thomas SHL. Clin Chem 2017; online early: doi: 10.1373/clinchem.2017.275867:

Abstract and full text available from: http://dx.doi.org/10.1373/clinchem.2017.275867

Chemical warfare agent simulants for human volunteer trials of emergency decontamination: A systematic review James T, Wyke S, Marczylo T, Collins S, Gaulton T, Foxall K, Amlôt R, Duarte-Davidson R. J Appl Toxicol 2017; online early: doi: 10.1002/jat.3527:

Abstract and full text available from: http://dx.doi.org/10.1002/jat.3527

10

Inhaled loxapine for agitation in intoxicated patients: a case series Roncero C, Ros-Cucurull E, Palma-Álvarez RF, Abad AC, Fadeuilhe C, Casas M, Grau-López L. Clin Neuropharmacol 2017; online early: doi: 10.1097/WNF.0000000000000252:

Abstract and full text available from: http://dx.doi.org/10.1097/WNF.0000000000000252

The percutaneous toxicokinetics of VX in a damaged skin porcine model and the evaluation of WoundStat™ as a topical decontaminant Lydon H, Hall C, Matar H, Dalton C, Chipman JK, Graham JS, Chilcott RP. J Appl Toxicol 2017; online early: doi: 10.1002/jat.3542:

Abstract and full text available from: http://dx.doi.org/10.1002/jat.3542

Predictors of thallium exposure and its relation with preterm birth Jiang Y, Xia W, Zhang B, Pan X, Liu W, Jin S, Huo W, Liu H, Peng Y, Sun X, Zhang H, Zhou A, Xu S, Li Y. Environ Pollut 2017; online early: doi: 10.1016/j.envpol.2017.09.080:

Abstract and full text available from: http://dx.doi.org/10.1016/j.envpol.2017.09.080

11

TOXICOLOGY Beauval N, Antherieu S, Soyez M, Gengler N, Grova N, General Howsam M, Hardy EM, Fischer M, Appenzeller BMR, Blaauboer BJ. Goossens JF, Allorge D, Garçon G, Lo-Guidice J-M, Garat A. In vitro, ex vivo, in vivo toxicology, the terminology issue. Chemical evaluation of electronic cigarettes: multicomponent Toxicol In Vitro 2017; 45: iii-iiv. analysis of liquid refills and their corresponding aerosols. J Anal Toxicol 2017; 41: 670-8. Choudhary S, Osborne T, Adler RR, McDorman KS, Dillberger JE, Ochoa R. Beck R, Atherton DS, Kloda S, Dye DW, Robinson CA. Career transition points in toxicologic pathology: Quantification of loperamide by gas chromatography mass management and consulting. spectrometry. Toxicol Pathol 2017; online early: J Anal Toxicol 2017; online early: doi: 10.1093/jat/bkx069: doi: 10.1177/0192623317736299: Bonichon M, Combès A, Desoubries C, Bossée A, Pichon V. Elamin MEMO, James DA, Holmes P, Jackson G, Development of immunosorbents coupled on-line to Thompson JP, Sandilands EA, Bradberry S, Thomas SHL. immobilized pepsin reactor and micro liquid chromatog- Reductions in emergency department visits after primary raphy-tandem mass spectrometry for analysis of healthcare use of the UK National Poisons Information butyrylcholinesterase in human plasma. Service. J Chromatogr A 2017; online early: Clin Toxicol 2017; online early: doi: 10.1016/j.chroma.2017.10.033: doi: 10.1080/15563650.2017.1390120: Borg D, Kolb E, Lantigua C, Stripp R. Golka K, Ickstadt K, Selinski S, Hengstler JG, Wilhelm M. Chiral analysis of in oral fluid samples: Third symposium on Environmental Toxicology in North a method to distinguish licit from illicit drug use. Rhine-Westphalia, Germany: Interdisciplinary Research J Anal Toxicol 2017; online early: doi: 10.1093/jat/bkx079: Activities in Toxicology, Statistics, Hygiene and Medicine : meeting report on a symposium held in Dortmund May 7-8, Brown MR, Garside H, Thompson E, Atwal S, Bean C, 2015. Goodall T, Sullivan M, Graham MJ. Arch Toxicol 2017; online early: doi: 10.1007/s00204- Development and application of a dual rat and human 017-2093-8: AHR activation assay. Toxicol Sci 2017; online early: doi: 10.1093/toxsci/kfx188: Leist M, Ghallab A, Graepel R, Marchan R, Hassan R, Bennekou SH, Limonciel A, Vinken M, Schildknecht S, Butler DC, Shanks K, Behonick GS, Smith D, Presnell SE, Waldmann T, Danen E, van Ravenzwaay B, Kamp H, Gardner Tormos LM. I, Godoy P, Bois FY, Braeuning A, Reif R, Oesch F, Drasdo D, Three cases of fatal acrylfentanyl toxicity in the United Höhme S, Schwarz M, Hartung T, Braunbeck T, Beltman J, States and a review of literature. Vrieling H, Sanz F, Forsby A, Gadaleta D, Fisher C. J Anal Toxicol 2017; online early: doi: 10.1093/jat/bkx083: Adverse outcome pathways: opportunities, limitations and open questions. Canfield DV, Dubowski KM, Whinnery JM, Forster EM. Arch Toxicol 2017; online early: doi: 10.1007/s00204- Pilot-reported beta-lockers identified by forensic toxicology 017-2045-3: analysis of postmortem specimens. J Anal Toxicol 2017; online early: doi: 10.1093/jat/bkx076: Liang X, Feswick A, Simmons D, Martyniuk CJ. Environmental toxicology and omics: a question of sex. Cornthwaite HM, Labine L, Watterson JH. J Proteomics 2017; online early: Semi-quantitative analysis of tramadol, dextromethorphan doi: 10.1016/j.jprot.2017.09.010: and metabolites in decomposed skeletal tissues by ultra performance liquid chromatography quadrupole time of Stewart J. flight mass spectrometry (UPLC-qTOF-MS). Ecotoxicology: It's time for a hard re-look. Drug Test Anal 2017; online early: doi: 10.1002/dta.2327:

Environ Toxicol Chem 2017; online early: da Silva ACC, Raasch JR, Vargas TG, Peteffi GP, Hahn RZ, doi: 10.1002/etc.4001: Antunes MV, Perassolo MS, Linden R.

Simultaneous determination of fluoxetine and Analytical toxicology norfluoxetine in dried blood spots using high-performance Allibe N, Richeval C, Phanithavong M, Faure A, Allorge D, liquid chromatography-tandem mass spectrometry. Paysant F, Stanke-Labesque F, Eysseric-Guerin H, Gaulier Clin Biochem 2017; online early: J-M. doi: 10.1016/j.clinbiochem.2017.10.002: Fatality involving ocfentanil documented by identification of metabolites. Eangoor P, Indapurkar AS, Vakkalanka M, Yeh JS, Knaack JS. Drug Test Anal 2017; online early: doi: 10.1002/dta.2326: Rapid and sensitive ELISA screening assay for several paralytic shellfish in human urine. Andreassen TN, Havnen H, Spigset O, Falch BMH, J Anal Toxicol 2017; online early: doi: 10.1093/jat/bkx072: Skråstad RB. High throughput UPLC®-MSMS method for the analysis of Escriva L, Manyes L, Font G, Berrada H. phosphatidylethanol (PEth) 16:0/18:1, a specific biomarker analysis of human urine by LC-MS/MS: a for consumption, in whole blood. comparative extraction study. J Anal Toxicol 2017; online early: doi: 10.1093/jat/bkx075: Toxins (Basel) 2017; 9: 27.

Barroso J, Díez-Buitrago B, Saa L, Möller M, Briz N, Pavlov V. Feng X, Xiang P, Chen H, Shen M. Specific bioanalytical optical and photoelectrochemical LC-MS-MS with post-column reagent addition for the assays for detection of in alcoholic beverages. determination of zolpidem and its metabolite zolpidem Biosens Bioelectron 2018; 101: 116-22. phenyl-4-carboxylic acid in oral fluid after a single dose.

12

J Anal Toxicol 2017; online early: doi: 10.1093/jat/bkx062: Papsun D, Isenschmid D, Logan BK. Observed carfentanil concentrations in 355 blood specimens Fujita Y, Mita T, Usui K, Kamijo Y, Kikuchi S, Onodera M, from forensic investigations. Fujino Y, Inoue Y. J Anal Toxicol 2017; online early: doi: 10.1093/jat/bkx068: Toxicokinetics of the synthetic - pyrrolidinohexanophenone. Powers D, Erickson S, Swortwood MJ. J Anal Toxicol 2017; online early: doi: 10.1093/jat/bkx080: Quantification of morphine, codeine, and thebaine in home-brewed poppy seed tea by LC-MS/MS. Grandin F, Picard-Hagen N, Gayrard V, Puel S, Viguié C, J Forensic Sci 2017; online early: doi: 10.1111/1556- Toutain P-L, Debrauwer L, Lacroix MZ. 4029.13664: Development of an on-line solid phase extraction ultra performance liquid chromatography technique coupled to Pozebon D, Scheffler GL, Dressler VL. tandem mass spectrometry for quantification of bisphenol S Elemental hair analysis: a review of procedures and and bisphenol S glucuronide: Applicability to toxicokinetic applications. investigations. Anal Chim Acta 2017; 992: 1-23. J Chromatogr A 2017; online early: doi: 10.1016/j.chroma.2017.10.020: Procaccianti P, Farè F, Argo A, Casagni E, Arnoldi S, Facheris S, Visconti GL, Roda G, Gambaro V. Griswold MK, Chai PR, Krotulski AJ, Friscia M, Chapman Determination of propofol by GC/MS and fast GC/MS-TOF BP, Varma N, Boyer EW, Logan BK, Babu KM. in two cases of poisoning. A novel oral fluid assay (LC-QTOF-MS) for the detection of J Anal Toxicol 2017; online early: doi: 10.1093/jat/bkx056: fentanyl and clandestine opioids in oral fluid after reported heroin overdose. Sun J-F, Wang C, Shao B, Wang Z, Xue D, Liu Y, Niu Y. J Med Toxicol 2017; online early: doi: 10.1007/s13181- Fast on-site visual detection of active ricin using a 017-0632-6: combination of high efficient dual-recognition affinity magnetic enrichment and a specific AuNP probe. Hoiseth G, Arnestad M, Karinen R, Morini L, Rogde S, Anal Chem 2017; online early: Sempio C, Vindenes V, Øiestad ÅML. doi: 10.1021/acs.analchem.7b02944: Is hair analysis useful in postmortem cases? J Anal Toxicol 2017; online early: doi: 10.1093/jat/bkx077: Tam CC, Cheng LW, He X, Merrill P, Hodge D, Stanker LH. A monoclonal-monoclonal antibody based capture ELISA Meier UCJ, Briellmann T, Scheurer E, Dussy F. for abrin. Sample preparation method for the combined extraction of Toxins (Basel) 2017; 9: 328. ethyl glucuronide and drugs of abuse in hair. Drug Test Anal 2017; online early: doi: 10.1002/dta.2314: Tufkova SG, Yankov IV, Paskaleva DA. Clinical laboratory tests in some acute exogenous Merkley ED, Jenson SC, Arce JS, Melville AM, Leiser OP, poisonings. Wunschel DS, Wahl KL. Folia Med (Plovdiv) 2017; 59: 303-9. Ricin-like proteins from the castor plant do not influence liquid chromatography-mass spectrometry detection of Ullah S, Sandqvist S, Beck O. ricin in forensically relevant samples. A liquid chromatography and tandem mass spectrometry Toxicon 2017; online early: method to determine 28 non-volatile drugs of abuse in doi: 10.1016/j.toxicon.2017.10.004: exhaled breath. J Pharm Biomed Anal 2017; 148: 251-8. Montesano C, Vannutelli G, Fanti F, Vincenti F, Gregori A, Rita Togna A, Canazza I, Marti M, Sergi M. Williams M, Martin J, Galettis P. Identification of MT-45 metabolites: in silico prediction, in A validated method for the detection of 32 in vitro incubation with rat hepatocytes and in vivo confirmation. oral fluid. J Anal Toxicol 2017; 41: 688-97. J Anal Toxicol 2017; 41: 659-69.

Musshoff F, Thieme D, Schwarz G, Sachs H, Skopp G, Wu F, Scroggin TL, Metz TD, McMillin GA. Franz T. Development of a liquid chromatography-tandem mass Determination of hydroxy metabolites of in hair spectrometry method for the simultaneous determination samples for proof of consumption. of four cannabinoids in umbilical cord tissue. Drug Test Anal 2017; online early: doi: 10.1002/dta.2317: J Anal Toxicol 2017; online early: doi: 10.1093/jat/bkx078:

Mutlu E, Pierfelice J, McIntyre BS, Cunny HC, Kissling GE, Yang C-A, Liu H-C, Lin D-L, Liu RH, Hsieh Y-Z, Wu S-P. Burback B, Waidyanatha S. Simultaneous quantitation of methamphetamine, Simultaneous quantitation of 2-hydroxy-4-methoxy- , opiates and their metabolites in urine by SPE benzophenone, a sunscreen ingredient, and its metabolites and LC-MS-MS. in Harlan Sprague Dawley rat plasma following perinatal J Anal Toxicol 2017; online early: doi: 10.1093/jat/bkx057: dietary exposure. J Anal Toxicol 2017; online early: doi: 10.1093/jat/bkx070: Yeter O. Identification of the synthetic cannabinoid 1-(4- Narkowicz S, Jaszczak E, Polkowska Z, Kielbratowska B, cyanobutyl)-N-(2-phenylpropan-2-yl)-1H-indazole-3- Kotlowska A, Namiesnik J. carboxamide (CUMYL-4CN-BINACA) in plant material and Determination of thiocyanate as a biomarker of tobacco quantification in post-mortem blood samples. smoke constituents in selected biological materials of J Anal Toxicol 2017; online early: doi: 10.1093/jat/bkx061: human origin. Biomed Chromatogr 2017; online early: Zheng H, Wang Z, Liu W, Jin H, Zhang J. doi: 10.1002/bmc.4111: Toxicokinetics of and brucine after the oral administration of Biqi capsule to rats by RRLC-MS/MS.

13

Biomed Chromatogr 2017; online early: J Toxicol Environ Health A 2017; online early: doi: doi: 10.1002/bmc.4117: 10.1080/15287394.2017.1384156:

Zhou J, Xu J, Cai Z-X, Huang B-F, Jin M-C, Ren Y-P. Mirabelli D. Simultaneous determination of five Alternaria toxins in Letter on: "Cosmetic talc as a risk factor for pleural cereals using QuEChERS-based methodology. mesothelioma: a weight of evidence evaluation of the J Chromatogr B Biomed Sci Appl 2017; 1068-1069: 15-23. epidemiology". Inhal Toxicol 2017; 29: 341. Biomarkers Chen Y, Dale Thurman J, Kinter LB, Bialecki R, Eric Pierozan P, Karlsson O. McDuffie J. PFOS induces proliferation, cell-cycle progression, and Perspectives on using a multiplex human kidney safety malignant phenotype in human breast epithelial cells. biomarker panel to detect cisplatin-induced tubular toxicity Arch Toxicol 2017; online early: doi: 10.1007/s00204- in male and female Cynomolgus monkeys. 017-2077-8: Toxicol Appl Pharmacol 2017; online early: doi: 10.1016/j.taap.2017.10.010: Protano C, Astolfi ML, Canepari S, Andreoli R, Mutti A, Valeriani F, Romano S, V, Antonucci A, Mattei V, Lin H, Ewing LE, Koturbash I, Gurley BJ, Miousse IR. Martellucci S, Vitali M. MicroRNAs as biomarkers for liver injury: current Exposure to individual and multiple carcinogenic metals knowledge, challenges and future prospects. during paediatric age: an experience from an Italian urban Food Chem Toxicol 2017; online early: scenario. doi: 10.1016/j.fct.2017.10.026: Ann Ig 2017; 29: 494-503.

Maza-Quiroga R, García-Marchena N, Romero-Sanchiz P, Prueitt RL, Lynch HN, Zu K, Shi L, Goodman JE. Barrios V, Pedraz M, Serrano A, Nogueira-Arjona R, Ruiz Dermal exposure to toluene diisocyanate and respiratory JJ, Soria M, Campos R, Chowen JA, Argente J, Torrens M, cancer risk. López-Gallardo M, Marco EM, Rodríguez de Fonseca F, Environ Int 2017; online early: Pavón FJ, Araos P. doi: 10.1016/j.envint.2017.09.017: Evaluation of plasma cytokines in patients with cocaine use disorders in abstinence identifies transforming growth Sannu A, Radha R, Mathews A, Padmakumari MR, factor alpha (TGF) as a potential biomarker of Prahladan A, James FV. consumption and dual diagnosis. Ifosfamide-induced malignancy of ureter and bladder. PeerJ 2017; 5: e3926. Cureus 2017; 9: e1594.

Narkowicz S, Jaszczak E, Polkowska Z, Kielbratowska B, Snodin DJ. Kotlowska A, Namiesnik J. The cancer threshold of toxicological concern (TTC) in Determination of thiocyanate as a biomarker of tobacco relation to foodstuffs and pharmaceuticals: a potentially smoke constituents in selected biological materials of useful concept compromised by a dubious derivation. human origin. Hum Exp Toxicol 2017; online early: Biomed Chromatogr 2017; online early: doi: 10.1177/960327117735571: doi: 10.1002/bmc.4111: Verma H, Sharma T, Gupta S, Banerjee BD. Carcinogenicity CYP1A1 expression and organochlorine pesticides level in the etiology of bladder cancer in North Indian population. Choo WH, Moon B, Song S, Oh SM. Hum Exp Toxicol 2017; online early: Morphological transformation induced by silver doi: 10.1177/0960327117734623: nanoparticles in Balb/c 3T3 A31-1-1 mouse cell model to evaluate in vitro carcinogenic potential. Environ Health Toxicol 2017; online early: Cardiotoxicity doi: 10.5620/eht.e2017016: Binaghi G, Congia D, Cossa S, Massidda S, Pasqualucci D, Pilo F, Serra E, Angelucci E, Porcu M. Desbiolles A, Roudier C, Goria S, Stempfelet M, Kairo C, Cardiogenic shock during first infusion of anthracycline Quintin C, Bidondo M-L, Monnereau A, Vacquier B. chemotherapy in a patient with Hodgkin lymphoma: an Cancer incidence in adults living in the vicinity of nuclear unusual event. power plants in France, based on data from the French Cardiology 2018; 139: 7-10. Network of Cancer Registries. Int J Cancer 2017; online early: doi: 10.1002/ijc.31116: Brown AC. Heart toxicity related to herbs and dietary supplements: Finkelstein MM. online table of case reports. part 4 of 5. Re: Brent L. Finley, Stacey M. Benson & Gary M. Marsh J Diet Suppl 2017; online early: (2017): Cosmetic talc as a risk factor for pleural doi: 10.1080/19390211.2017.1356418: mesothelioma: a weight of evidence evaluation of the epidemiology, Inhalation Toxicology, Dharanipradab M, Viswanathan S, Kumar GR, Krishnamurthy DOI: 10.1080/08958378.2017.1336187. V, Stanley DD. Inhal Toxicol 2017; online early: Yellow phosphorus-induced Brugada phenocopy. doi: 10.1080/08958378.2017.1385662: J Electrocardiol 2017; online early: doi: 10.1016/j.jelectrocard.2017.08.033: Huang H, Ji Y, Zhang J, Su Z, Liu M, Tong J, Ge C, Chen T, Li J. Dokur M, Dogan M, Yagmur EA. Aberrant DNA methylation in radon and/or cigarette smoke- -related cardiomyopathy and acute pulmonary induced malignant transformation in BEAS-2B human lung edema in a child who is stung by abdullahbayrami. cell line. Turk J Emerg Med 2017; 17: 104-8.

14

J Community Hosp Intern Med Perspect 2017; 7: 222-6. Fradley MG, Groarke JD, Laubach J, Alsina M, Lenihan DJ, Cornell RF, Maglio M, Shain KH, Richardson PG, Moslehi J. Shah C, Gong Y, Szady A, Sun Q, Pepine CJ, Langaee T, Recurrent cardiotoxicity potentiated by the interaction of Lucas AR, Moreb JS. proteasome inhibitor and immunomodulatory therapy for Unanticipated Cardiotoxicity Associated with Targeted the treatment of multiple myeloma. Anticancer Therapy in Patients with Hematologic Br J Haematol 2017; online early: doi: 10.1111/bjh.14970: Malignancies Patients: Natural History and Risk Factors. Cardiovasc Toxicol 2017; online early: Hondebrink L, Nugteren-van Lonkhuyzen JJ, Rietjens SJ, doi: 10.1007/s12012-017-9429-8: Brunt TM, Venhuis B, Soerdjbalie-Maikoe V, Smink BE, van Riel AJHP, de Vries I. Song YJ, Fan T, Quan CY, Cao SH, Zhang Y, Shao XH. Fatalities, cerebral hemorrhage, and severe cardiovascular Nedaplatin-induced arrhythmia: retrospective analysis of toxicity after exposure to the new psychoactive substance three cases. 4-fluoroamphetamine: a prospective cohort study. J Coll Physicians Surg Pak 2017; 27: 657-9. Ann Emerg Med 2017; online early: doi: 10.1016/j.annemergmed.2017.07.482: Wang K, Pearlstein KA, Patchett ND, Deal AM, Mavroidis P, Jensen BC, Lipner MB, Zagar TM, Wang Y, Lee CB, Eblan Hughes A, Hendrickson RG, Chen BCC, Valento M. MJ, Rosenman JG, Socinski MA, Stinchcombe TE, Marks LB. Letter in response to "fatal cardiac glycoside poisoning Heart dosimetric analysis of three types of cardiac toxicity in due to mistaking foxglove for comfrey". patients treated on dose-escalation trials for Stage III non- Clin Toxicol 2017; online early: small-cell lung cancer. doi: 10.1080/15563650.2017.1398329: Radiother Oncol 2017; online early: doi: 10.1016/j.radonc.2017.10.001: Jing L, Yang M, Li Y, Yu Y, Liang B, Cao L, Zhou X, Peng S, Sun Z. Metallothionein prevents doxorubicin cardiac toxicity by Dermal toxicity indirectly regulating the uncoupling proteins 2. De Luca F, Losappio LM, Mirone C, Schroeder JW, Citterio Food Chem Toxicol 2017; online early: A, Aversano MG, Scibilia J, Pastorello EA. doi: 10.1016/j.fct.2017.10.035: Tolerated drugs in subjects with severe cutaneous adverse reactions (SCARs) induced by anticonvulsants and review Joy G, Whiskey E, Bolstridge M, Porras-Segovia A, of the literature. McDonagh TA, Plymen CM, Shergill SS. Clin Mol Allergy 2017; 15: 16. Hearts and minds: real-life cardiotoxicity with clozapine in psychosis. Frey N, Bodmer M, Bircher A, Ruegg S, Jick SS, Meier CR, J Clin Psychopharmacol 2017; online early: Spoendlin J. doi: 10.1097/JCP.0000000000000792: The risk of Stevens-Johnson syndrome and toxic epidermal necrolysis in new users of antiepileptic drugs. Leone O, Agostini V, Foà A, Cerbelli B, di Gioia CRT, Epilepsia 2017; online early: doi: 10.1111/epi.13925: Aromatario M, Ciallella C, Lucena J, d'Amati G. Cardiac pathologic findings in three unusual cases of Jaber BM, Petroianu GA, Rizvi SA, Borai A, Saleh NA, Hala sudden cardiac death related to anorexiant drugs. SM, Saleh AM. Hum Pathol 2017; online early: Protective effect of metoclopramide against organo- doi: 10.1016/j.humpath.2017.09.014: phosphate-induced apoptosis in the murine skin fibroblast L929. Muñiz AE. J Appl Toxicol 2017; online early: doi: 10.1002/jat.3543: Valproic acid overdose review of a case with electro- cardiographic changes. Kim H, Lee SG, Rhie J. J Emerg Med 2017; 53: 333-8. Dermal and neural toxicity caused by acrylamide exposure in two Korean grouting workers: a case report. Page CB, Ryan NM, Isbister GK. Ann Occup Environ Med 2017; 29: 50. The safety of high-dose insulin euglycaemia therapy in toxin-induced cardiac toxicity. Lydon H, Hall C, Matar H, Dalton C, Chipman JK, Graham Clin Toxicol 2017; online early: JS, Chilcott RP. doi: 10.1080/15563650.2017.1391391: The percutaneous toxicokinetics of VX in a damaged skin porcine model and the evaluation of WoundStat™ as a Platt DE, Hariri E, Salameh P, Helou M, Sabbah N, Merhi topical decontaminant. M, Chammas E, Ammar W, Abchee AB, Zalloua PA. J Appl Toxicol 2017; online early: doi: 10.1002/jat.3542: Association of waterpipe smoking with myocardial infarction and determinants of metabolic syndrome among Olteanu C, Shear NH, Chew HF, Hashimoto R, Alhusayen catheterized patients. R, Whyte-Croasdaile S, Finkelstein Y, Burnett M, Ziv M, Inhal Toxicol 2017; online early: Sade S, Jeschke MG, Dodiuk-Gad RP. doi: 10.1080/08958378.2017.1384085: Severe physical complications among survivors of Stevens- Johnson syndrome and toxic epidermal necrolysis. Sakhuja A, Sztajnkrycer M, Vallabhajosyula S, Drug Saf 2017; online early: doi: 10.1007/s40264-017- Cheungpasitporn W, Patch R, III, Jentzer J. 0608-0: National trends and outcomes of cardiac arrest in opioid overdose. Prueitt RL, Lynch HN, Zu K, Shi L, Goodman JE. Resuscitation 2017; 121: 84-9. Dermal exposure to toluene diisocyanate and respiratory cancer risk. Salama A, Levin Y, Jha P, Alweis R. Environ Int 2017; online early: Ventricular fibrillation due to overdose of loperamide, the doi: 10.1016/j.envint.2017.09.017: "poor man's methadone".

15

Raffalli C, Clouet E, Kuresepi S, Damiens M-H, Lepoittevin Effect of valproic acid administration during pregnancy on J-P, Pallardy M, Ferret P-J, Giménez-Arnau E, Kerdine- postnatal development of cerebellar cortex and the possible Römer S. protective role of folic acid. Fragrance allergens linalool and limonene allylic Folia Morphol (Praha) 2017; online early: hydroperoxides in skin allergy: mechanisms of action doi: 10.5603/FM.a2017.0100: focusing on transcription factor Nrf2. Toxicol Sci 2017; online early: doi: 10.1093/toxsci/kfx207: Warembourg C, Botton J, Lelong N, Rouget F, Khoshnood B, Le GF, Monfort C, Labat L, Pierre F, Heude B, Slama R, Yuliwulandari R, Kristin E, Prayuni K, Sachrowardi Q, Multigner L, Charles MA, Cordier S, Garlantezec R. Suyatna FD, Menaldi SL, Wichukchinda N, Mahasirimongkol Prenatal exposure to glycol ethers and cryptorchidism and S, Cavallari LH. hypospadias: a nested case-control study. Association of the HLA-B alleles with carbamazepine- Occup Environ Med 2017; online early: induced Stevens-Johnson syndrome/toxic epidermal doi: 10.1136/oemed-2017-104391: necrolysis in the Javanese and Sundanese population of Indonesia: the important role of the HLA-B75 serotype. Yorifuji T, Kashima S, Suryadhi MAH, Abudureyimu K. Pharmacogenomics 2017; online early: doi: 10.2217/pgs- Temporal trends of infant and birth outcomes in Minamata 2017-0103: after severe methylmercury exposure. Environ Pollut 2017; online early: Developmental toxicology doi: 10.1016/j.envpol.2017.09.060:

Babel'ová J, Šefcíková Z, Cikoš Š, Špirková A, Kovaríková V, Koppel J, Makarevich AV, Chrenek P, Fabian D. Driving under the influence of alcohol Exposure to neonicotinoid insecticides induces and other drugs embryotoxicity in mice and rabbits. Chihuri S, Li G. Toxicology 2017; 392: 71-80. Use of prescription opioids and motor vehicle crashes: a

meta analysis. Boland MR, Polubriaginof F, Tatonetti NP. Accid Anal Prev 2017; 109: 123-31. Development of a machine learning algorithm to classify drugs of unknown fetal effect. Sci Rep 2017; 7: 12839. Epidemiology Boyle KL, Periyanayagam U, Babu KM, Rice BT, Bisanzo M. Cowell WJ, Wright RJ. Pediatric poisonings in a rural Ugandan emergency Sex-specific effects of combined exposure to chemical and department. non-chemical stressors on neuroendocrine development: a Pediatr Emerg Care 2017; online early: review of eecent findings and putative mechanisms. doi: 10.1097/PEC.0000000000001265: Curr Environ Health Rep 2017; online early: doi: 10.1007/s40572-017-0165-9: Dowell D, Arias E, Kochanek K, Anderson R, Guy GP, Jr., Losby JL, Baldwin G. Dathe K, Schaefer C. Contribution of opioid-involved poisoning to the change in Drug safety in pregnancy: the German Embryotox institute. life expectancy in the United States, 2000-2015. Eur J Clin Pharmacol 2017; online early: JAMA 2017; 318: 1065-7. doi: 10.1007/s00228-017-2351-y: Masters RK, Tilstra AM, Simon DH. Jiang Y, Xia W, Zhang B, Pan X, Liu W, Jin S, Huo W, Liu H, Explaining recent mortality trends among younger and Peng Y, Sun X, Zhang H, Zhou A, Xu S, Li Y. middle-aged White Americans. Predictors of thallium exposure and its relation with Int J Epidemiol 2017; online early: preterm birth. doi: 10.1093/ije/dyx127: Environ Pollut 2017; online early: doi: 10.1016/j.envpol.2017.09.080: Neufeld M, Rehm J. Effectiveness of policy changes to reduce harm from Ma T, Yin X, Han R, Ding J, Zhang H, Han X, Li D. unrecorded alcohol in Russia between 2005 and now. Effects of in utero exposure to di-n-butyl phthalate on Int J Drug Policy 2018; 51: 1-9. testicular development in rat. Int J Environ Res Public Health 2017; 14: 1284. Orsini J, Din N, Elahi E, Gomez A, Rajayer S, Malik R, Jean E. Clinical and epidemiological characteristics of patients with Martens DS, Cox B, Janssen BG, Clemente DBP, Gasparrini A, acute drug intoxication admitted to ICU. Vanpoucke C, Lefebvre W, Roels HA, Plusquin M, Nawrot TS. J Community Hosp Intern Med Perspect 2017; 7: 202-7. Prenatal air pollution and newborns' predisposition to accelerated biological aging. Rönkä S, Karjalainen K, Martikainen P, Mäkelä P. JAMA Pediatr 2017; online early: Social determinants of drug-related mortality in a general doi: 10.1001/jamapediatrics.2017.3024: population. Drug Alcohol Depend 2017; 181: 37-43. Sagir D, Eren B, Yilmaz BD, Eren Z, Keles ON, Gökçe AB. Effects of prenatal PPAR-gamma agonist rosiglitazone Forensic toxicology exposure on rat hippocampus development in a time- Alvarez JC, Lasne L, Etting I, Cheron G, Abadie V, dependent manner: A stereological and histopathological Fabresse N, Larabi IA. study. Hair analysis does not allow to discriminate between acute Hum Exp Toxicol 2017; online early: and chronic administrations of a drug in young children. doi: 10.1177/0960327117730883: Int J Legal Med 2017; online early: doi: 10.1007/s00414- 017-1720-5: Shona SI, Rizk AA, El Sadik AO, Emam HY, Ali EN.

16

Bartoli C, Berland-Benhaim C, Tuchtan-Torrents L, Kintz P, Variation in DNA-damage responses to an inhalational Leonetti G, Pelissier-Alicot A-L. carcinogen (1,3-Butadiene) in relation to strain-specific Suicide by overdose in prison: a study of three differences in chromatin accessibility and gene transcription cases. profiles in C57BL/6J and CAST/EiJ mice. J Forensic Sci 2017; online early: doi: 10.1111/1556- Environ Health Perspect 2017; 125: 107006. 4029.13671: Elmhiri G, Gloaguen C, Grison S, Kereselidze D, Elie C, Tack Butler DC, Shanks K, Behonick GS, Smith D, Presnell SE, K, Benderitter M, Lestaevel P, Legendre A, Souidi M. Tormos LM. DNA methylation and potential multigenerational epigenetic Three cases of fatal acrylfentanyl toxicity in the United effects linked to uranium chronic low-dose exposure in States and a review of literature. gonads of males and females rats. J Anal Toxicol 2017; online early: doi: 10.1093/jat/bkx083: Toxicol Lett 2017; online early: doi: 10.1016/j.toxlet.2017.10.004: Canfield DV, Dubowski KM, Whinnery JM, Forster EM. Pilot-reported beta-lockers identified by forensic toxicology Gadaleta D, Porta N, Vrontaki E, Manganelli S, Manganaro analysis of postmortem specimens. A, Sello G, Honma M, Benfenati E. J Anal Toxicol 2017; online early: doi: 10.1093/jat/bkx076: Integrating computational methods to predict mutagenicity of aromatic azo compounds. Kintz P. J Environ Sci Health [C] 2017; online early: Hair analysis in forensic toxicology: an updated review doi: 10.1080/10590501.2017.1391521: with a special focus on pitfalls.

Curr Pharm Des 2017; online early: Hilgert Jacobsen-Pereira C, Dos Santos CR, Troina Maraslis doi: 10.2174/1381612823666170929155628: F, Pimentel L, Feijo AJL, Iomara Silva C, de Medeiros GDS,

Costa Zeferino R, Curi Pedrosa R, Weidner Maluf S. Krämer M, Heese P, Banger M, Madea B, Hess C. Range of therapeutic prothipendyl and prothipendyl Markers of genotoxicity and oxidative stress in farmers exposed to pesticides. sulfoxide concentrations in clinical blood samples. Drug Test Anal 2017; online early: doi: 10.1002/dta.2319: Ecotoxicol Environ Saf 2017; 148: 177-83.

Magni PA, Pazzi M, Vincenti M, Converso V, Dadour IR. Senapati VA, Kansara K, Shanker R, Dhawan A, Kumar A. Development and validation of a method for the detection Monitoring characteristics and genotoxic effects of of alpha- and beta- (organochlorine insecticide) engineered nanoparticle-protein corona. in Calliphora vomitoria (diptera: calliphoridae). Mutagenesis 2017; 32: 479-90. J Med Entomol 2017; online early: doi: 10.1093/jme/tjx177: Tugcu FT, Turhan K, Karadayi M, Gulluce M. Merkley ED, Jenson SC, Arce JS, Melville AM, Leiser OP, Genotoxic evaluation of newly synthesized iminothiazol- Wunschel DS, Wahl KL. idinones. Ricin-like proteins from the castor plant do not influence Toxicol Ind Health 2017; online early: liquid chromatography-mass spectrometry detection of doi: 10.1177/0748233717730492: ricin in forensically relevant samples. Toxicon 2017; online early: Wang X, Liu Y, Wang J, Nie Y, Chen S, Hei TK, Deng Z, doi: 10.1016/j.toxicon.2017.10.004: Wu L, Zhao G, Xu A.

Amplification of arsenic genotoxicity by TiO2 nanoparticles Papsun D, Isenschmid D, Logan BK. in mammalian cells: new insights from physicochemical Observed carfentanil concentrations in 355 blood specimens interactions and mitochondria. from forensic investigations. Nanotoxicology 2017; online early: J Anal Toxicol 2017; online early: doi: 10.1093/jat/bkx068: doi: 10.1080/17435390.2017.1388861:

Powers D, Erickson S, Swortwood MJ. Quantification of morphine, codeine, and thebaine in Hepatotoxicity home-brewed poppy seed tea by LC-MS/MS. Antunes MM, Araújo AM, Diniz AB, Pereira RVS, Alvarenga J Forensic Sci 2017; online early: doi: 10.1111/1556- DM, David BA, Rocha RM, Lopes MAF, Marchesi SC, 4029.13664: Nakagaki BN, Carvalho E, Marques PE, Ryffel B, Quesniaux V, Brito RG, Filho JCA, Cara DC, Rezende RM, Menezes GB. Sato T, Nishioka H, Tsuboi K, Katagi M, Miki A, Saito T, IL-33 signalling in liver immune cells enhances drug- Abe S, Nomura M, Kitagawa M, Tsuchihashi H, Suzuki K. induced liver injury and inflammation. Detection of butane gas inhalation at 16 days after Inflamm Res 2017; online early: doi: 10.1007/s00011- hypoxic encephalopathy: a case report. 017-1098-3: Leg Med 2017; 29: 34-7. Cai Y, Sun W, Zhang X, Lin Y, Chen H, Li H. Takayasu T, Yamamoto H, Ishida Y, Nosaka M, Kawaguchi Osthole prevents acetaminophen-induced liver injury in mice. M, Kuninaka Y, Kimura A, Kondo T. Acta Pharmacol Sin 2017; online early: Postmortem distribution of chlorpyrifos-methyl, fenitrothion, doi: 10.1038/aps.2017.129: and their metabolites in body fluids and organ tissues of an intoxication case. Dokumacioglu E, Iskender H, Aktas MS, Hanedan B, Leg Med (Tokyo) 2017; 29: 44-50. Dokumacioglu A, Sen TM, Musmul A. The effect of sulforaphane on oxidative stress and Genotoxicity inflammation in rats with toxic hepatitis induced by Chappell GA, Israel JW, Simon JM, Pott S, Safi A, Eklund acetaminophene. K, Sexton KG, Bodnar W, Lieb JD, Crawford GE, Rusyn I, Bratisl Lek Listy 2017; 118: 453-9. Furey TS.

17

Dubinkina VB, Tyakht AV, Odintsova VY, Yarygin KS, Kovarsky BA, Pavlenko AV, Ischenko DS, Popenko AS, Sakharkar P. Alexeev DG, Taraskina AY, Nasyrova RF, Krupitsky EM, Lead poisoning due to herbal medications. Shalikiani NV, Bakulin IG, Shcherbakov PL, Skorodumova Indian J Clin Biochem 2017; 32: 500-1. LO, Larin AK, Kostryukova ES, Abdulkhakov RA, Abdulkhakov SR, Malanin SY, Ismagilova RK, Grigoryeva TV, Wang B, Abbott L, Childs K, Taylor C, Agarwal K, Cormack Ilina EN, Govorun VM. I, Miquel R, Suddle A. Links of gut microbiota composition with alcohol Dolutegravir-induced liver injury leading to sub-acute liver dependence syndrome and alcoholic liver disease. failure requiring transplantation: a case report and review Microbiome 2017; 5: 141. of literature. Int J STD AIDS 2017; online early: Heise T, Schmidt F, Knebel C, Rieke S, Haider W, Geburek doi: 10.1177/0956462417734099: I, Niemann L, Marx-Stoelting P. Hepatotoxic combination effects of three azole fungicides Wang H, Peng Y, Zhang T, Lan Q, Zhao H, Wang W, Zhao in a broad dose range. Y, Wang X, Pang J, Wang S, Zheng J. Arch Toxicol 2017; online early: doi: 10.1007/s00204-017- Metabolic epoxidation is a critical step for the development 2087-6: of benzbromarone-induced hepatotoxicity. Drug Metab Dispos 2017; online early: Kazemi S, Mousavi Kani SN, Rezazadeh L, Pouramir M, doi: 10.1124/dmd.117.077818: Ghasemi-Kasman M, Moghadamnia AA. Low dose administration of Bisphenol A induces liver Wang S, Sui S, Liu Z, Peng C, Liu J, Luo D, Fan X, Liu C, toxicity in adult rats. Lu W-Y. Biochem Biophys Res Commun 2017; online early: doi: Protective roles of hepatic gamma-aminobutyric acid 10.1016/j.bbrc.2017.10.074: signaling in acute ethanol exposure-induced liver injury. J Appl Toxicol 2017; online early: doi:10.1002/jat.3544: Khivsara A, Raj JP, Hegde D, Rao M. Topiramate-induced acute liver injury: a rare adverse effect. Wang Y-C, Yang K-W, Lee T-YP, Lin C-L, Liaw G-W, Hung Indian J Pharmacol 2017; 49: 254-6. D-Z, Kao C-H, Chen W-K, Yang T-Y. Increased risk of pyogenic liver abscess in patients with Kirpich I, McClain C. alcohol intoxication: a population-based retrospective More alcohol, more liver injury: not always true. cohort study. Alcohol Alcohol 2017; online early: Alcohol 2017; 64: 23-8. doi: 10.1093/alcalc/agx064:

Koneru M, Sahu BD, Mir SM, Ravuri HG, Kuncha M, Inhalation toxicity Mahesh KJ, Kilari EK, Sistla R. Al-Sawalha NA, Al-Bo'ul HF, Alzoubi KH, Khabour OF, Capsaicin, the pungent principle of peppers, ameliorates Thanawala VJ. alcohol-induced acute liver injury in mice via modulation of Effect of prenatal waterpipe tobacco smoke on airway matrix metalloproteinases. inflammation in murine model of asthma of adult offspring Can J Physiol Pharmacol 2017; online early: doi: mice. 10.1139/cjpp-2017-0473: Inhal Toxicol 2017; 29: 366-73.

Lin H, Ewing LE, Koturbash I, Gurley BJ, Miousse IR. Al-Zubaidi ES, Rabee AM. MicroRNAs as biomarkers for liver injury: current The risk of occupational exposure to mercury vapor in knowledge, challenges and future prospects. some public dental clinics of Baghdad city, Iraq. Food Chem Toxicol 2017; online early: Inhal Toxicol 2017; online early: doi: 10.1016/j.fct.2017.10.026: doi: 10.1080/08958378.2017.1369601:

Lin L, Li H, Lin H, Zhang M, Qu C, Yan L, Yin X, Ni J. Catlin NR, Willson CJ, Stout M, Kissling GE, Waidyanatha Application of iTRAQ-based quantitative proteomics S, Baker GL, Hayden BK, Wyde M. approach to identify deregulated proteins associated with Evaluation of the respiratory tract toxicity of ortho- liver toxicity Induced by Polygonum multiflorum in rats. phthalaldehyde, a proposed alternative for the chemical Cell Physiol Biochem 2017; 43: 2102-16. disinfectant glutaraldehyde. Inhal Toxicol 2017; online early: Mejias Manzano MLÁ, Giráldez Gallego A, Serrano Jiménez M. doi: 10.1080/08958378.2017.1390015: Hepatic veno-occlusive disease induced by Chinese medicinal herbs. Chappell GA, Israel JW, Simon JM, Pott S, Safi A, Eklund Rev Esp Enferm Dig 2017; online early: K, Sexton KG, Bodnar W, Lieb JD, Crawford GE, Rusyn I, doi: 10.17235/reed.2017.4969/2017: Furey TS. Variation in DNA-damage responses to an inhalational Pezeshki Z, Khosravi A, Nekuei M, Khoshnood S, Zandi E, carcinogen (1,3-Butadiene) in relation to strain-specific Eslamian M, Talebi A, Emami SNed, Nematbakhsh M. differences in chromatin accessibility and gene transcription Time course of cisplatin-induced nephrotoxicity and hepato- profiles in C57BL/6J and CAST/EiJ mice. toxicity. Environ Health Perspect 2017; 125: 107006. J Nephropathol 2017; 6: 163-7. Finkelstein MM. Rivera P, Pastor A, Arrabal S, Decara J, Vargas A, Sánchez- Re: Brent L. Finley, Stacey M. Benson & Gary M. Marsh Marín L, Pavón FJ, Serrano A, Bautista D, Boronat A, de la (2017): Cosmetic talc as a risk factor for pleural Torre R, Baixeras E, Lucena MI, De Fonseca FR, Suárez J. mesothelioma: a weight of evidence evaluation of the Acetaminophen-induced liver injury alters the acyl ethanol- epidemiology, Inhalation Toxicology, DOI: 10.1080/ amine-based anti-inflammatory signaling system in liver. 08958378.2017.1336187. Front Pharmacol 2017; 8: 705. Inhal Toxicol 2017; online early:

18

doi: 10.1080/08958378.2017.1385662: Integration of mechanistic and pharmacokinetic information to derive oral reference dose and margin-of- Lee JH, Yu IJ. exposure values for hexavalent chromium. Human exposure to polyhexamethylene guanidine J Appl Toxicol 2017; online early: doi: 10.1002/jat.3545: phosphate from humidifiers in residential settings: cause of serious lung disease. Mechanisms of toxicity Toxicol Ind Health 2017; online early: Ramachandran A, Jaeschke H. doi: 10.1177/0748233717724983: Acetaminophen toxicity novel insights into mechanisms and future perspectives. Leem J-H, Lee J-H. Gene Expr 2017; online early: From specific Humidifier disinfectants disease to doi: 10.3727/105221617X15084371374138: Humidifier disinfectants syndrome. Environ Health Toxicol 2017; online early: Song X, Fiatikenston SS, Kong L, Zhao J. doi: 10.5620/eht.e2017017: Molecular mechanisms of nickel induced neurotoxicity and chemoprevention. Madhubabu G, Yenugu S. Toxicology 2017; 392: 47-54. Exposure to allethrin-based mosquito coil smoke during gestation and postnatal development affects reproductive Medication errors function in male offspring of rat. Personne M. Inhal Toxicol 2017; 29: 374-85. A 10-fold bolus dose of N-acetylcysteine with fatal conse-

quences. Mirabelli D. Clin Toxicol 2017; online early: Letter on: "Cosmetic talc as a risk factor for pleural doi: 10.1080/15563650.2017.1394466: mesothelioma: a weight of evidence evaluation of the epidemiology". Inhal Toxicol 2017; 29: 341. Metabolism Vevelstad M, Oiestad EL, Nerem E, Arnestad M, Bogen IL. Pujalte I, Serventi A, Noel A, Dieme D, Haddad S, Studies on para-methoxymethamphetamine (PMMA) Bouchard M. metabolite pattern and influence of CYP2D6 genetics in human liver microsomes and authentic samples from fatal Characterization of aerosols of titanium dioxide PMMA intoxications. nanoparticles following three generation methods using an optimized aerosolization system designed for experimental Drug Metab Dispos 2017; online early: inhalation studies. doi: 10.1124/dmd.117.077263: Toxics 2017; 5: 14. Wang X, Anadón A, Qinghua W, Qiao F, Ares I, Martínez- Larrañaga M-R, Yuan Z, Martínez M-A. Williams LJ, Chen L, Zosky GR. Mechanism of neonicotinoid toxicity: impact on oxidative The respiratory health effects of geogenic (earth derived) stress and metabolism. PM . 10 Annu Rev Pharmacol Toxicol 2017; online early: doi: Inhal Toxicol 2017; 29: 342-55. 10.1146/annurev-pharmtox-010617-052429:

Kinetics Nephrotoxicity Fujita Y, Mita T, Usui K, Kamijo Y, Kikuchi S, Onodera M, Afravy M, Angali K, Khodadadi A, Ahmadizadeh M. Fujino Y, Inoue Y. The protective effect of Buffalo's milk against toluene Toxicokinetics of the synthetic cathinone -pyrrolidino-  induced-nephrotoxicity in rats. hexanophenone. J Nephropathol 2017; 6: 174-9. J Anal Toxicol 2017; online early: doi: 10.1093/jat/bkx080: Byber K, Lison D, Verougstraete V, Dressel H, Hotz P. Response to letter to the editor from Elinder and Nordberg Lohitnavy M, Chitsakhon A, Jomprasert K, Lohitnavy O, concerning Byber et al. 2016. Cadmium or cadmium Reisfeld B. compounds and chronic kidney disease in workers and the Development of a physiologically based pharmacokinetic general population: a systematic review, Crit Rev Toxicol. model of paraquat. 46(3):191-240. DOI: 0.3109/10408444.2015.1076375. Conf Proc IEEE Eng Med Biol Soc 2017; 2017: 2732-5. Crit Rev Toxicol 2017; online early: doi: 10.1080/10408444.2017.1375899: Lydon H, Hall C, Matar H, Dalton C, Chipman JK, Graham JS, Chilcott RP. Cao SS, Yan M, Hou ZY, Chen Y, Jiang YS, Fan XR, Fang PF, The percutaneous toxicokinetics of VX in a damaged skin Zhang Bk. porcine model and the evaluation of WoundStat™ as a Danshen modulates Nrf2-mediated signaling pathway in topical decontaminant. cisplatin-induced renal injury. J Appl Toxicol 2017; online early: doi: 10.1002/jat.3542: J Huazhong Univ Sci Technol Med Sci 2017; 37: 761-5.

Poet T, Hays S. Cheng T-C, Hsu Y-W, Lu F-J, Chen Y-Y, Tsai N-M, Chen W- Extrapolation of plasma clearance to understand species K, Tsai C-F. differences in toxicokinetics of bisphenol A. Nephroprotective effect of electrolyzed reduced water Xenobiotica 2017; online early: against cisplatin-induced kidney toxicity and oxidative doi: 10.1080/00498254.2017.1379626: damage in mice. J Chin Med Assoc 2017; online early: Thompson CM, Kirman CR, Hays SM, Suh M, Harvey SE, doi: 10.1016/j.jcma.2017.08.014: Proctor DM, Rager JE, Haws LC, Harris MA.

19

Heidari-Soreshjani S, Asadi-Samani M, Yang Q, Saeedi- Comfort N, Re DB. Boroujeni A. Sex-specific neurotoxic effects of organophosphate Phytotherapy of nephrotoxicity-induced by cancer drugs: pesticides across the life course. an updated review. Curr Environ Health Rep 2017; online early: J Nephropathol 2017; 6: 254-63. doi: 10.1007/s40572-017-0171-y:

Heydari M, Ahmadizadeh M, Ahmadi Angali K. Di Cesare ML, Maresca M, Micheli L, Farina C, Scherz MW, Ameliorative effect of vitamin E on trichloroethylene- Ghelardini C. induced nephrotoxicity in rats. A rat model of FOLFOX-induced neuropathy: effects of oral J Nephropathol 2017; 6: 168-73. dimiracetam in comparison with duloxetine and pregabalin. Cancer Chemother Pharmacol 2017; online early: doi: John JF, Falci DR, Rigatto MH, Oliveira RD, Kremer TG, 10.1007/s00280-017-3449-8: Zavascki AP. Severe infusion-related adverse events and renal failure in Duan Y, Peng L, Shi H, Jiang Y. patients receiving high-dose intravenous polymyxin B. The effects of lead on GABAergic interneurons in . Antimicrob Agents Chemother 2017; online early: doi: Toxicol Ind Health 2017; online early: 10.1128/AAC.01617-17: doi: 10.1177/0748233717732902:

Lin E-Y, Bayarsengee U, Wang C-C, Chiang Y-H, Cheng C-W. El-Agamy SE, Abdel-Aziz AK, Wahdan S, Esmat A, Azab SS. The natural compound 2,3,5,4'-tetrahydroxystilbene-2-O- Astaxanthin ameliorates doxorubicin-induced cognitive beta-d glucoside protects against adriamycin-induced impairment (chemobrain) in experimental rat model: impact nephropathy through activating the Nrf2-Keap1 antioxidant on oxidative, inflammatory, and apoptotic machineries. pathway. Mol Neurobiol 2017; online early: doi: 10.1007/s12035- Environ Toxicol 2017; online early: 017-0797-7: doi: 10.1002/tox.22496: Engstrom AK, Xia Z. Pezeshki Z, Khosravi A, Nekuei M, Khoshnood S, Zandi E, Lead exposure in late adolescence through adulthood Eslamian M, Talebi A, Emami SNed, Nematbakhsh M. impairs short-term spatial memory and the neuronal Time course of cisplatin-induced nephrotoxicity and differentiation of adult-born cells in C57BL/6 male mice. hepatotoxicity. Neurosci Lett 2017; 661: 108-13. J Nephropathol 2017; 6: 163-7. Fujimura M, Usuki F. Powell D, Hassall L, Scholes D, Al-Jubouri M. In situ different antioxidative systems contribute to the False acute kidney injury alert due to model car fuel ingestion. site-specific methylmercury neurotoxicity in mice. BMJ Case Rep 2017; doi: 10.1136/bcr-2017-221134: Toxicology 2017; 392: 55-63.

Wang X, Han L, Li G, Peng W, Gao X, Klaassen CD, Fan G, Goyagi T. Zhang Y. Long-duration sevoflurane exposure with the normoxic Identification of natural products as inhibitors of human carrier gas increase the neural apoptosis and impair the organic anion transporters (OAT1 and OAT3) and their long-term cognitive function in neonatal rats. protective effect on mercury-induced toxicity. Brain Res Rev 2017; online early: Toxicol Sci 2017; online early: doi: 10.1016/j.brainres.2017.10.014: doi: 10.1093/toxsci/kfx216: Gust J, Hay KA, Hanafi L-A, Li D, Myerson D, Gonzalez- Cuyar LF, Yeung C, Liles WC, Wurfel M, Lopez JA, Chen J, Neurotoxicity Chung D, Harju-Baker S, Özpolat T, Fink KR, Riddell SR, Abdraboh ME, Abdeen SH, Salama M, Elhussiny M, El- Maloney DG, Turtle CJ. Sherbini YM, Eldeen NM. Endothelial activation and blood-brain barrier disruption in Developmental neurotoxic effects of a low dose of TCE on neurotoxicity after adoptive immunotherapy with CD19 3D neurosphere system. CAR-T cells. Biochem Cell Biol 2017; online early: doi: 10.1139/bcb- Cancer Discov 2017; online early: doi: 10.1158/2159- 2017-0089: 8290.CD-17-0698:

Beske PH, Bradford AB, Hoffman KM, Mason S, McNutt PM. Hopman AJG, Baart JA, Brand HS. In vitro and ex vivo screening of candidate therapeutics to Articaine and neurotoxicity - a review. restore neurotransmission in nerve terminals intoxicated Br Dent J 2017; online early: doi: 10.1038/sj.bdj.2017.782: by botulinum serotype A1. Toxicon 2017; online early: Imamura F, Cooper TK, Hasegawa-Ishii S, Sonobe T, doi: 10.1016/j.toxicon.2017.10.017: Haouzi P. Hydrogen sulfide specifically alters Nad(P)H quinone de- Campbell AE, Chambers CD, Allen CPG, Hedge C, Sumner P. hydrogenase 1 (Nqo1) olfactory neurons in the rat. Impairment of manual but not saccadic response inhibition Neuroscience 2017; online early: following acute alcohol intoxication. doi: 10.1016/j.neuroscience.2017.10.014: Drug Alcohol Depend 2017; online early: doi: 10.1016/j.drugalcdep.2017.08.022: Jiang M, Karasawa T, Steyger PS. Aminoglycoside-induced cochleotoxicity: a review. Cancelliere A, Blohm E, Neavyn M. Front Cell Neurosci 2017; 11: 308. A dangerous chase: severe neurocognitive impairment and death following smoked heroin. Karbanowicz T, Dover E, Mu X, Tabor A, Rodriguez-Valle M. Clin Toxicol 2017; online early: Extracellular expression of the HT1 neurotoxin from the doi: 10.1080/15563650.2017.1392559: Australian paralysis tick in two Saccharomyces cerevisiae strains.

20

Toxicon 2017; 140: 1-10. Occupational toxicology Al-Zubaidi ES, Rabee AM. Kim H, Lee SG, Rhie J. The risk of occupational exposure to mercury vapor in Dermal and neural toxicity caused by acrylamide exposure some public dental clinics of Baghdad city, Iraq. in two Korean grouting workers: a case report. Inhal Toxicol 2017; online early: Ann Occup Environ Med 2017; 29: 50. doi: 10.1080/08958378.2017.1369601:

Law-Ye B, Dodet P, Hermann B, Trunet S, Dormont D, Bassig BA, Dai Y, Vermeulen R, Ren D, Hu W, Duan H, Niu Y, Pyatigorskaya N, Leclercq D. Xu J, Shiels MS, Kemp TJ, Pinto LA, Fu W, Meliefste K, Zhou Progressive white-matter demyelination in delayed CO B, Yang J, Ye M, Jia X, Meng T, Wong JYY, Bin P, Hosgood poisoning encephalopathy. HD, III, Hildesheim A, Silverman DT, Rothman N, Zheng Y, J Neuroradiol 2017; online early: Lan Q. doi: 10.1016/j.neurad.2017.09.008: Occupational exposure to diesel engine exhaust and alterations in immune/inflammatory markers: a cross- Li L, Jiao Y, Jin T, Sun H, Li S, Jin C, Hu S, Ji J, Xiang L. sectional molecular epidemiology study in China. Phenolic alkaloid oleracein E attenuates oxidative stress Carcinogenesis 2017; online early: and neurotoxicity in AlCl3-treated mice. doi: 10.1093/carcin/bgx081: Life Sci 2017; online early: doi: 10.1016/j.lfs.2017.10.019: Black B, Dodson RF, Bruce JR, Poye LW, Henschke C, Moon JM, Chun BJ, Shin MH, Lee SD. Loewen G. Serum N-terminal proBNP, not troponin I, at presentation A clinical assessment and lung tissue burden from an predicts long-term neurologic outcome in acute charcoal- individual who worked as a Libby vermiculite miner. burning carbon monoxide intoxication. Inhal Toxicol 2017; online early: Clin Toxicol 2017; online early: doi: 10.1080/08958378.2017.1372536: doi: 10.1080/15563650.2017.1394464: Byber K, Lison D, Verougstraete V, Dressel H, Hotz P. Rossetto O. Response to letter to the editor from Elinder and Nordberg The binding of botulinum to different peripheral concerning Byber et al. 2016. Cadmium or cadmium neurons. compounds and chronic kidney disease in workers and the Toxicon 2017; online early: general population: a systematic review, Crit Rev Toxicol. doi: 10.1016/j.toxicon.2017.10.010: 46(3):191-240. DOI: 0.3109/10408444.2015.1076375. Crit Rev Toxicol 2017; online early: Song X, Fiatikenston SS, Kong L, Zhao J. doi: 10.1080/10408444.2017.1375899: Molecular mechanisms of nickel induced neurotoxicity and chemoprevention. Chokhandre P, Singh S, Kashyap GC. Toxicology 2017; 392: 47-54. Prevalence, predictors and economic burden of morbidities among waste-pickers of Mumbai, India: a cross-sectional Wang H, Zhang L, Abel GM, Storm DR, Xia Z. study. Cadmium exposure impairs cognition and olfactory J Occup Med Toxicol 2017; 12: 30. memory in male C57BL/6 mice. Toxicol Sci 2017; online early: doi: 10.1093/toxsci/kfx202: Dai Y, Ren D, Bassig BA, Vermeulen R, Hu W, Niu Y, Duan H, Ye M, Meng T, Xu J, Bin P, Shen M, Yang J, Fu W, Meliefste Weis S, Büttner A. K, Silverman D, Rothman N, Lan Q, Zheng Y. Neurotoxicology and drug-related disorders. Occupational exposure to diesel engine exhaust and Handb Clin Neurol 2017; 145: 181-92. serum cytokine levels. Environ Mol Mutagen 2017; online early: Wilke C, Grosshans D, Duman J, Brown P, Li J. doi: 10.1002/em.22142: Radiation-induced cognitive toxicity: Pathophysiology and interventions to reduce toxicity in adults. Damalas CA, Koutroubas SD. Neuro Oncol 2017; online early: Farmers' training on use Is associated with doi: 10.1093/neuonc/nox195: elevated safety behavior. Toxics 2017; 5: 19. Yan Y, Qiao S, Kikuchi C, Zaja I, Logan S, Jiang C, Arzua T, Bai X. Dos Santos E, Villa A, Garnier R, Dufayet L, Langrand J. Propofol induces apoptosis of neurons but not astrocytes, Surveillance and analysis of occupational carbon monoxide oligodendrocytes, or neural stem cells in the neonatal poisoning in the Paris region. mouse hippocampus. Ann Work Expo Health 2017; 61: 986-93. Brain Sci 2017; 7: 130. Galbraith DA. Zaki SM, Ahmed EM, Motawie AG, Abdel FS. Diacetyl and occupational bronchiolitis obliterans: comments N-acetylcysteine versus progesterone on the cisplatin- on Rose, CS: EARLY DETECTION, CLINICAL DIAGNOSIS induced peripheral neurotoxicity. AND MANAGEMENT OF LUNG DISEASE FROM EXPOSURE Folia Morphol (Praha) 2017; online early: TO DIACETYL, Toxicology (2017), https://doi.org/10.1016/ doi: 10.5603/FM.a2017.0090: j.tox.2017.03.019. Toxicology 2017; online early: Zukas AM, Schiff D. doi: 10.1016/j.tox.2017.10.009: Neurological complications of new chemotherapy agents. Neuro Oncol 2017; online early: Hilgert Jacobsen-Pereira C, Dos Santos CR, Troina Maraslis doi: 10.1093/neuonc/nox115: F, Pimentel L, Feijo AJL, Iomara Silva C, de Medeiros GDS, Costa Zeferino R, Curi Pedrosa R, Weidner Maluf S.

21

Markers of genotoxicity and oxidative stress in farmers Heavy metals identification and exposure at workplace exposed to pesticides. environment its extent of accumulation in blood of iron Ecotoxicol Environ Saf 2017; 148: 177-83. and steel recycling foundry workers of Lahore, Pakistan. Pak J Pharm Sci 2017; 30: 1233-8. Hu J, Cantrell P, Nand A. Comprehensive biological monitoring to assess isocyanates Ribeiro E, Ladeira C, Viegas S. and solvents exposure in the NSW Australia motor vehicle Occupational exposure to bisphenol A (BPA): a reality that repair industry. still needs to be unveiled. Ann Work Expo Health 2017; 61: 1015-23. Toxics 2017; 5: 22.

Ibrayeva A, Turdalieva B, Aimbetova G, Pleva L. Riccò M, Cattani S, Signorelli C. General health status among firefighters and rescue Zinc exposure for female workers in a galvanizing plant in operations workers. Northern Italy. Georgian Med News 2017; 270: 130-5. Int J Occup Med Environ Health 2017; online early: doi: 10.13075/ijomeh.1896.00878: Keir JLA, Akhtar US, Matschke DMJ, Kirkham TL, Chan HM, Ayotte P, White PA, Blais JM. van Tongeren M, Lamb J, Cherrie JW, MacCalman L, Elevated exposures to polycyclic aromatic hydrocarbons and Basinas I, Hesse S. other organic mutagens in Ottawa firefighters participating Validation of lower tier exposure tools used for REACH: in emergency, on-shift fire suppression. comparison of tools estimates with available exposure Environ Sci Technol 2017; online early: measurements. doi: 10.1021/acs.est.7b02850: Ann Work Expo Health 2017; 61: 921-38.

Kim H, Kwon HJ, Rhie J, Lim S, Kang YD, Eom SY, Lim H, Zhang J-X, Li N, Wang H, Shen T, Zhu Q-X. Myong JP, Roh S. The immune response in trichloroethylene hypersensitivity The relationship between spontaneous abortion and syndrome: a review. female workers in the semiconductor industry. Toxicol Ind Health 2017; online early: Ann Occup Environ Med 2017; 29: 49. doi: 10.1177/0748233717731213:

Kramer DM, Holness DL, Haynes E, McMillan K, Berriault Ocular toxicity C, Kalenge S, Lightfoot N. Bhatti MT, Salama AKS. From awareness to action: Sudbury, mining and Neuro-ophthalmic side effects of molecularly targeted occupational disease in a time of change. cancer drugs. Work 2017; 58: 149-62. Eye (Lond) 2017; online early: doi: 10.1038/eye.2017.222:

Lamb J, Galea KS, Miller BG, Hesse S, van Tongeren M. Klein KA, Warren AK, Baumal CR, Hedges TR, III. Between-user reliability of tier 1 exposure assessment Optical coherence tomography findings in methanol tools used under REACH. toxicity. Ann Work Expo Health 2017; 61: 939-53. Int J Retina Vitreous 2017; 3: 36.

Ledda C, Iavicoli I, Bracci M, Avola R, Senia P, Santarelli L, Liao R, Yan F, Zeng Z, Wang H, Qiu K, Xu J, Zheng W. Pomara C, Rapisarda V. IGF-1 activates PI3K/Akt signaling to protect human Serum lipid, lipoprotein, and apolipoprotein profiles in retinal pigment epithelial cells from amiodarone-induced workers exposed to low arsenic levels: lipid profiles and oxidative injury. occupational arsenic exposure. Br J Pharmacol 2017; online early: doi: 10.1111/bph.14078: Toxicol Lett 2017; online early: doi: 10.1016/j.toxlet.2017.10.014: Shields M, Andrew N, LaHood B, Saha N. Eye injuries following ocular exposure to euphorbia plant Liu N, Xu L, Cai Y. sap: an Australian and New Zealand case series. Methyl siloxanes in barbershops and residence indoor dust Clin Exp Ophthalmol 2017; online early: and the implication for human exposures. doi: 10.1111/ceo.13081: Sci Total Environ 2017; online early: doi: 10.1016/j.scitotenv.2017.09.250: Stern EM, Johnson JS, Mazzulla DA. Highly accelerated onset of hydroxychloroquine macular Lovreglio P, De Palma G, Barbieri A, Andreoli R, Drago I, retinopathy. Greco L, Gallo E, Diomede L, Scaramuzzo P, Ricossa MC, Ochsner J 2017; 17: 280-3. Fostinelli J, Apostoli P, Soleo L. Biological monitoring of exposure to low concentrations of Paediatric toxicology benzene in workers at a metallurgical coke production plant: Alvarez-Ortega N, Caballero-Gallardo K, Olivero-Verbel J. new insights into S-phenylmercapturic acid and urinary Low blood lead levels impair intellectual and hematological benzene. function in children from Cartagena, Caribbean coast of Biomarkers 2017; online early: Colombia. doi: 10.1080/1354750X.2017.1387935: J Trace Elem Med Biol 2017; 44: 233-40.

Manyilizu WB, Mdegela RH, Helleve A, Skjerve E, Kazwala Alvarez JC, Lasne L, Etting I, Cheron G, Abadie V, R, Nonga H, Muller MHB, Lie E, Lyche J. Fabresse N, Larabi IA. Self-reported symptoms and pesticide use among farm Hair analysis does not allow to discriminate between acute workers in Arusha, northern Tanzania: a cross sectional study. and chronic administrations of a drug in young children. Toxics 2017; 5: 24. Int J Legal Med 2017; online early: doi: 10.1007/s00414- 017-1720-5: Riaz MA, Akhtar ABT, Riaz A, Mujtaba G, Ali M, Ijaz B.

22

Bautista F, Moreno L, Marshall L, Pearson ADJ, Geoerger B, Paoletti X. Knipper E, Banta-Green CJ, Jimenez N. Revisiting the definition of dose-limiting toxicities in Opioid use disorder and misuse: a review of the paediatric oncology phase I clinical trials: an analysis from epidemiology and medical implications for pediatric the Innovative Therapies for Children with Cancer anesthesiologists. Consortium. Paediatr Anaesth 2017; 27: 1070-6. Eur J Cancer 2017; 86: 275-84. Koehrn K, Hospital J, Woolf A, Lowry J. Beynon SJ, Chaturvedi S. Pediatric environmental health: using data on toxic Datura intoxication in an adolescent male: a challenge in chemical emissions in practice. the Internet era. Curr Probl Pediatr Adolesc Health Care 2017; online early: J Paediatr Child Health 2017; online early: doi: 10.1016/j.cppeds.2017.09.002: doi: 10.1111/jpc.13726: Mitchell KJ, Nolte K, Turner HA, Hamby S, Jones LM. Bilbao NA. Exposure to medication overdose as an adversity in Vitamin D toxicity in young breastfed infants: report of 2 childhood. cases. J Pediatr Nurs 2017; online early: Glob Pediatr Health 2017; 4: doi: 10.1016/j.pedn.2017.09.006: doi: 10.1177/2333794X17731695. Protano C, Astolfi ML, Canepari S, Andreoli R, Mutti A, Boyle KL, Periyanayagam U, Babu KM, Rice BT, Bisanzo M. Valeriani F, Romano S, V, Antonucci A, Mattei V, Martellucci Pediatric poisonings in a rural Ugandan emergency S, Vitali M. department. Exposure to individual and multiple carcinogenic metals Pediatr Emerg Care 2017; online early: during paediatric age: an experience from an Italian urban doi: 10.1097/PEC.0000000000001265: scenario. Ann Ig 2017; 29: 494-503. Etzel RA. Foreword-Pediatric environmental health: using data on Razdan P, Patthi B, Kumar JK, Agnihotri N, Chaudhari P, toxic chemical emissions in practice. Prasad M. Curr Probl Pediatr Adolesc Health Care 2017; online early: Effect of fluoride concentration in drinking water on doi: 10.1016/j.cppeds.2017.09.003: intelligence quotient of 12-14-year-old children in Mathura district: a cross-sectional study. Fluharty ME, Heron J, Munafò MR. J Int Soc Prev Community Dent 2017; 7: 252-8. Longitudinal associations of social cognition and substance use in childhood and early adolescence: findings from the Schmidt CW. Avon Longitudinal Study of Parents and Children. After the screening: what happens next for children with Eur Child Adolesc Psychiatry 2017; online early: doi: elevated blood lead? 10.1007/s00787-017-1068-x: Environ Health Perspect 2017; 125: 102001.

Giménez N, Magro N, Cortés N, Guitart R. Seidel C, von Bueren AO, Bojko S, Hoffmann M, Pietsch T, Poisoning after ingestion of Spartium junceum seeds: Gielen GH, Warmuth-Metz M, Bison B, Kortmann RD, dose-dependent effects in three boys. Kramm CM. J Emerg Med 2017; 53: e41-e44. Concurrent radiotherapy with temozolomide vs. concurrent radiotherapy with a cisplatinum-based polychemotherapy Handley MA, Nelson K, Sanford E, Clarity C, Emmons-Bell regimen : acute toxicity in pediatric high-grade glioma S, Gorukanti A, Kennelly P. patients. Examining lead exposures in California through state- Strahlenther Onkol 2017; online early: issued health alerts for food contamination and an doi: 10.1007/s00066-017-1218-6: exposure-based candy testing program. Environ Health Perspect 2017; 125: 104503. Soares BP, Lequin MH, Huisman TAGM. Safety of contrast material use in children. Hauptman M, Woolf AD. Magn Reson Imaging Clin N Am 2017; 25: 779-85. Lead poisoning and children in foster care: diagnosis and management challenges. Stassinos G, Klein-Schwartz W. Clin Pediatr 2017; online early: Asenapine, iloperidone and lurasidone exposures in young doi: 10.1177/0009922817734364: children reported to U.S. poison centers. Clin Toxicol 2017; online early: Hauptman M, Bruccoleri R, Woolf AD. doi: 10.1080/15563650.2017.1388385: An update on childhood lead poisoning. Clin Pediatr Emerg Med 2017; 18: 181-92. Stoppel G, Eich H-T, Matuschek C, Kortmann R-D, Meyer F, Martinsson U, Nilsson K, Kristensen I, Vordermark D, Hon KL, Fung CK, Leung AK. Willich N, Christiansen H, Koch R, Steinmann D. Childhood lead poisoning: an overview. Lung toxicity after radiation in childhood: results of the Hong Kong Med J 2017; online early: International Project on Prospective Analysis of Radiotoxicity doi: 10.12809/hkmj176214: in Childhood and Adolescence. Radiother Oncol 2017; online early: Khandare AL, Gourineni SR, Validandi V. doi: 10.1016/j.radonc.2017.09.026: Dental fluorosis, nutritional status, kidney damage, and thyroid function along with bone metabolic indicators in Thomas AA, Mazor S. school-going children living in fluoride-affected hilly areas Unintentional marijuana exposure presenting as altered of Doda district, Jammu and Kashmir, India. mental status in the pediatric emergency department: a Environ Monit Assess 2017; 189: 579. case series.

23

J Emerg Med 2017; online early: doi: 10.1016/j.jemermed.2017.08.007: Reprotoxicity Ferdinand N, Herman NV, Omer Bebe NK, Augustave K, Tolia VN, Murthy K, Bennett MM, Miller ES, Benjamin DK, Valence M, Ghislaine NT, Herve T, Dorice AK, Sorelle D, Smith PB, Clark RH. Yacouba M. Antenatal methadone vs buprenorphine exposure and Antouka Super® induced oxidative stress and reproductive length of hospital stay in infants admitted to the intensive toxicity in male Japanese quail (Coturnix coturnix japonica). care unit with neonatal abstinence syndrome. Heliyon 2017; 3: e00410. J Perinatol 2017; online early: doi: 10.1038/jp.2017.157:

Guvvala PR, Ravindra JP, Rajani CV, Sivaram M, Selvaraju S. Weinhouse C, Ortiz EJ, Berky AJ, Bullins P, Hare-Grogg J, Protective role of epigallocatechin-3-gallate on arsenic Rogers L, Morales A-M, Hsu-Kim H, Pan WK. induced testicular toxicity in Swiss albino mice. Hair mercury level is associated with anemia and Biomed Pharmacother 2017; 96: 685-94. micronutrient status in children living near artisanal and small-scale gold mining in the Peruvian Amazon. Kim H, Kwon HJ, Rhie J, Lim S, Kang YD, Eom SY, Lim H, Am J Trop Med Hyg 2017; online early: Myong JP, Roh S. doi: 10.4269/ajtmh.17-0269: The relationship between spontaneous abortion and

female workers in the semiconductor industry. Weitzman M. Ann Occup Environ Med 2017; 29: 49. American Pediatric Society's 2017 John Howland award acceptance lecture: A tale of two toxicants-childhood exposure to lead and tobacco. Madhubabu G, Yenugu S. Pediatr Res 2017; online early: doi: 10.1038/pr.2017.240: Exposure to allethrin-based mosquito coil smoke during gestation and postnatal development affects reproductive Ying X, Gao Z-Y, Yan J, Zhang M, Wang J, Xu J, Markowitz M, function in male offspring of rat. Yan C-H. Inhal Toxicol 2017; 29: 374-85. Sources, symptoms and characteristics of childhood lead poisoning: experience from a lead specialty clinic in China. Martinez-Pinto J, Piquer B, Tiszavari M, Lara HE. Clin Toxicol 2017; online early: Neonatal exposure to estradiol valerate reprograms the rat doi: 10.1080/15563650.2017.1391392: ovary androgen receptor and anti-Mullerian hormone to a polycystic ovary phenotype. Zhang X-L, McGlothan JL, Miry O, Stansfield KH, Loth MK, Reprod Toxicol 2017; online early: Stanton PK, Guilarte TR. doi: 10.1016/j.reprotox.2017.10.005: 7,8-Dihydroxyflavone rescues lead-induced impairment of vesicular release: a novel therapeutic approach for lead Moreira N, Sandini TM, Reis-Silva TM, Navas-Suáresz P, intoxicated children. Auada AVV, Lebrun I, Flório JC, Bernardi MM, Spinosa HS. Toxicol Sci 2017; online early: doi: 10.1093/toxsci/kfx210: Ivermectin reduces motor coordination, serum testosterone, and central neurotransmitter levels but does not affect sexual motivation in male rats. Poisons information and poison Reprod Toxicol 2017; online early: information centres doi: 10.1016/j.reprotox.2017.10.002: Saheb Sharif-Askari F, Saheb Sharif-Askari N, Javadi M, Gholami K. Onaolapo AY, Oladipo BP, Onaolapo OJ. Adverse drug reactions reported to the drug and poison Cyclophosphamide-induced male subfertility in mice: an information center of Tehran, Iran. assessment of the potential benefits of Maca supplement. PLoS ONE 2017; 12: e0185450. Andrologia 2017; online early: doi: 10.1111/and.12911:

Polymorphisms Palmerini MG, Zhurabekova G, Balmagambetova A, Amsden JR, Gubbins PO. Nottola SA, Miglietta S, Belli M, Bianchi S, Cecconi S, Di Pharmacogenomics of triazole antifungal agents: Nisio V, Familiari G, Macchiarelli G. implications for safety, tolerability and efficacy. The pesticide lindane induces dose-dependent damage to Expert Opin Drug Metab Toxicol 2017; online early: doi: granulosa cells in an in vitro culture. 10.1080/17425255.2017.1391213: Reprod Biol 2017; online early: doi: 10.1016/j.repbio.2017.09.008: Fukuda M, Okumura M, Iwakiri T, Arimori K, Honda T, Kobayashi K, Senju H, Takemoto S, Ikeda T, Yamaguchi Rayburn ER, Gao L, Ding J, Ding H, Shao J, Li H. H, Nakatomi K, Matsuo N, Mukae H, Ashizawa K. FDA-approved drugs that are spermatotoxic in animals Relationship between UGT1A1*27 and UGT1A1*7 poly- and the utility of testing for human risk prediction. morphisms and irinotecan-related toxicities in patients J Assist Reprod Genet 2017; online early: with lung cancer. doi: 10.1007/s10815-017-1062-8: Thoracic Cancer 2017; online early: doi: 10.1111/1759- 7714.12535: Tang L, Zhao B, Zhang H, Du Q, Zhu J, Zhao Z, Chen C, Luo C, Kang Q, Yuan W, Bian S, Bi H, Sun H, Li Y. Yuliwulandari R, Kristin E, Prayuni K, Sachrowardi Q, Regulation of nonylphenol-induced reproductive toxicity in Suyatna FD, Menaldi SL, Wichukchinda N, Mahasirimongkol mouse spermatogonia cells by miR-361-3p. S, Cavallari LH. Mol Reprod Dev 2017; online early: Association of the HLA-B alleles with carbamazepine- doi: 10.1002/mrd.22923: induced Stevens-Johnson syndrome/toxic epidermal necrolysis in the Javanese and Sundanese population of Traesel GK, de Lima FF, dos Santos AC, Souza RIC, Indonesia: the important role of the HLA-B75 serotype. Cantadori DT, Kretschmer CR, Navarini VJ, Oesterreich SA. Pharmacogenomics 2017; online early: doi: 10.2217/pgs- Evaluation of embryotoxic and teratogenic effects of the oil 2017-0103: extracted from Caryocar brasiliense Cambess pulp in rats.

24

Food Chem Toxicol 2017; 110: 74-82. MANAGEMENT

Wilk A, Szypulska-Koziarska D, Wiszniewska B. General The toxicity of vanadium on gastrointestinal, urinary and Elamin MEMO, James DA, Holmes P, Jackson G, reproductive system, and its influence on fertility and Thompson JP, Sandilands EA, Bradberry S, Thomas SHL. fetuses malformations. Reductions in emergency department visits after primary Postepy Hig Med Dosw (Online) 2017; 71: 850-9. healthcare use of the UK National Poisons Information Service. Zhang L, Meng X, Xiang Z, Li D, Han X. Clin Toxicol 2017; online early: Roles of mmu_piR_003399 in microcystin-leucine arginine doi: 10.1080/15563650.2017.1390120: (MC-LR)-induced reproductive toxicity in the spermatogonial cells and testis. Gal Y, Mazor O, Falach R, Sapoznikov A, Kronman C, Sabo T. Toxicol Sci 2017; online early: doi: 10.1093/toxsci/kfx209: Treatments for pulmonary ricin intoxication: current aspects and future prospects.

Toxins (Basel) 2017; 9: 311. Risk assessment Jiang Y, Shi L, Guang AL, Mu Z, Zhan H, Wu Y. Gawarammana I, Buckley NA, Mohamed F, Naser K, Contamination levels and human health risk assessment of Jeganathan K, Ariyananada PL, Wunnapuk K, Dobbins TA, toxic heavy metals in street dust in an industrial city in Tomenson JA, Wilks MF, Eddleston M, Dawson AH. Northwest China. High-dose immunosuppression to prevent death after Environ Geochem Health 2017; online early: paraquat self-poisoning – a randomised controlled trial. doi: 10.1007/s10653-017-0028-1: Clin Toxicol 2017; online early: doi: 10.1080/15563650.2017.1394465: Salvo A, La Torre GL, Mangano V, Casale KE, Bartolomeo G, Santini A, Granata T, Dugo G. Hauptman M, Woolf AD. Toxic inorganic pollutants in foods from agricultural Lead poisoning and children in foster care: diagnosis and producing areas of Southern Italy: Level and risk management challenges. assessment. Clin Pediatr 2017; online early: Ecotoxicol Environ Saf 2017; 148: 114-24. doi: 10.1177/0009922817734364:

Scott-Fordsmand JJ, Peijnenburg WJGM, Semenzin E, Iman M, Rezaei R, Azimzadeh-Jamalkandi S, Shariati P, Nowack B, Hunt N, Hristozov D, Marcomini A, Irfan M-A, Kheradmand F, Salimian J. Jiménez AS, Landsiedel R, Tran L, Oomen AG, Bos PMJ, Th17/Treg immunoregulation and implications in treatment Hund-Rinke K. of sulfur mustard gas-induced lung diseases. Environmental risk assessment strategy for nanomaterials. Exp Rev Clin Immunol 2017; online early: Int J Environ Res Public Health 2017; 14: 1251. doi: 10.1080/1744666X.2017.1389646:

James T, Wyke S, Marczylo T, Collins S, Gaulton T, Foxall Suicide K, Amlôt R, Duarte-Davidson R. Bartoli C, Berland-Benhaim C, Tuchtan-Torrents L, Kintz P, Chemical warfare agent simulants for human volunteer Leonetti G, Pelissier-Alicot A-L. trials of emergency decontamination: a systematic review. Suicide by medication overdose in prison: a study of three J Appl Toxicol 2017; online early: doi: 10.1002/jat.3527: cases. J Forensic Sci 2017; online early: doi: 10.1111/1556- Lagisetty P, Klasa K, Bush C, Heisler M, Chopra V, Bohnert A. 4029.13671: Primary care models for treating opioid use disorders: What actually works? A systematic review. Chowdhury FR, Dewan G, Verma VR, Knipe DW, Isha IT, PLoS ONE 2017; 12: e0186315. Faiz MA, Gunnell DJ, Eddleston M. Bans of WHO class I pesticides in Bangladesh—Suicide Lindqvist E, Edman G, Hollenberg J, Nordberg P, Ösby U, prevention without hampering agricultural output. Forsberg S. Int J Epidemiol 2017; online early: Intensive care admissions due to poisoning. doi: 10.1093/ije/dyx157: Acta Anaesthesiol Scand 2017; 61: 1296-304.

Çelik C, Carus M, Büyükcam F. Lydon H, Hall C, Matar H, Dalton C, Chipman JK, Graham Pulmonary embolism due to exogenous estrogen JS, Chilcott RP. intoxication. The percutaneous toxicokinetics of VX in a damaged skin porcine model and the evaluation of WoundStat as a Am J Emerg Med 2017; online early: ™ topical decontaminant. doi: 10.1016/j.ajem.2017.07.084: J Appl Toxicol 2017; online early: doi: 10.1002/jat.3542:

Lee K. Morgan AM, Ibrahim MA, Hussien AM. A fatal case of acute bentazone overdose despite crico- The potential protective role of Akropower against thyroidotomy during cardiopulmonary resuscitation. Atrazine- induced humoral immunotoxicity in rabbits. Clin Exp Emerg Med 2017; online early: Biomed Pharmacother 2017; 96: 710-5. doi: 10.15441/ceem.15.056: Ruha A-M, Kleinschmidt KC, Greene S, Spyres MB, Brent J, Masters RK, Tilstra AM, Simon DH. Wax P, Padilla-Jones A, Campleman S, On behalf of the Explaining recent mortality trends among younger and ToxIC Snakebite Study Group. middle-aged White Americans. The epidemiology, clinical course, and management of Int J Epidemiol 2017; online early: snakebites in the North American snakebite registry. doi: 10.1093/ije/dyx127: J Med Toxicol 2017; online early: doi: 10.1007/s13181- 017-0633-5:

25

Verma V, Paul S, Ghose A, Eddleston M, Konradsen F. Zeng F-J, Chen C, Liu M-H. Treatment of self-poisoning at a tertiary level hospital in Allergic reactions to antivenom in a patient bitten twice by Bangladesh: Cost to patients and government. the same within a month: a rare case report and Trop Med Int Health 2017; online early: literature review. doi: 10.1111/tmi.12991: Chin J Traumatol 2017; online early: doi: 10.1016/j.cjtee.2016.12.004: Vilela SMF, Salcedo-Abraira P, Colinet I, Salles F, de Koning MC, Joosen MJA, Serre C, Horcajada P. Chelating agents Nanometric MIL-125-NH2 metal-organic framework as a Bjørklund G, Mutter J, Aaseth J. potential antidote carrier. Metal chelators and neurotoxicity: lead, mercury, and Nanomaterials (Basel) 2017; 7: 321. arsenic. Arch Toxicol 2017; online early: doi: 10.1007/s00204-017- Wen L, Jiang X, Sun J, Li X, Li X, Tian L, Li Y, Bai W. 2100-0: Cyanidin-3-O-glucoside promotes the biosynthesis of progesterone through the protection of mitochondrial function in Pb-exposed rat leydig cells. Idarucizumab Food Chem Toxicol 2017; online early: Yip L, Deng J-F. doi: 10.1016/j.fct.2017.10.008: The recommended dose of idarucizumab may not always be sufficient for sustained reversal of dabigatran: Zhao S, Xi H, Zuo Y, Wang Q, Wang Z, Yan Z. comment. Bicarbonate-activated hydrogen peroxide and efficient J Thromb Haemost 2017; online early: decontamination of toxic sulfur mustard and nerve gas doi: 10.1111/jth.13854: simulants. J Hazard Mater 2018; 344: 136-45. Lipid emulsion therapy Karaman K, Türkdogan KA, Deniz AT, Çanakçi SE. Antidotes Which is the best in carbamazepine overdose? Acetylcysteine Clin Case Rep 2017; 5: 1612-5.

Onoda A, Takeda K, Umezawa M. Pretreatment with N-acetyl cysteine suppresses chronic MB327 reactive astrogliosis following maternal nanoparticle Niessen KV, Seeger T, Rappengluck S, Wein T, Höfner G, exposure during gestational period. Wanner KT, Thiermann H, Worek F. Nanotoxicology 2017; online early: In vitro pharmacological characterization of the doi: 10.1080/17435390.2017.1388864: bispyridinium non-oxime compound MB327 and its 2- and 3- regioisomers. Personne M. Toxicol Lett 2017; online early: A 10-fold bolus dose of N-acetylcysteine with fatal conse- doi: 10.1016/j.toxlet.2017.10.009: quences. Clin Toxicol 2017; online early: Naloxone doi: 10.1080/15563650.2017.1394466: Bakhireva LN, Bautista A, Cano S, Shrestha S, Bachyrycz AM, Cruz TH. Zaki SM, Ahmed EM, Motawie AG, Abdel FS. Barriers and facilitators to dispensing of intranasal N-acetylcysteine versus progesterone on the cisplatin- naloxone by pharmacists. induced peripheral neurotoxicity. Subst Abus 2017; online early: Folia Morphol (Praha) 2017; online early: doi: 10.1080/08897077.2017.1391924: doi: 10.5603/FM.a2017.0090: Gulec N, Lahey J, Suozzi JC, Sholl M, MacLean CD, Antivenom Wolfson DL. Baudou FG, Litwin S, Lanari LC, Laskowicz RD, Damin CF, Basic and advanced EMS providers are equally effective in Chippaux J-P, de Roodt AR. naloxone administration for opioid overdose in Northern Antivenom against Crotalus durissus terrificus venom: New England. immunochemical reactivity and experimental neutralizing Prehosp Emerg Care 2017; online early: capacity. doi: 10.1080/10903127.2017.1371262: Toxicon 2017; online early: doi: 10.1016/j.toxicon.2017.10.009: Han JK, Hill LG, Koenig ME, Das N. Naloxone counseling for harm reduction and patient Harrison RA, Oluoch GO, Ainsworth S, Alsolaiss J, Bolton engagement. F, Arias A-S, Gutiérrez J-M, Rowley P, Kalya S, Ozwara H, Fam Med 2017; 49: 730-3. Casewell NR. Preclinical antivenom-efficacy testing reveals potentially Parran TV, Mace AG, Dahan YJ, Adelman CA, Kolganov M. disturbing deficiencies of snakebite treatment capability in Buprenorphine/naloxone maintenance therapy: an East Africa. observational retrospective report on the effect of dose on PLoS Negl Trop Dis 2017; 11: e0005969. 18 months retention in an office-based treatment program. Subst Abus 2017; 11: doi: 10.1177/1178221817731320. Tan CH, Liew JL, Tan NH, Khaldun IA, Maharani T, Khomvilai S, Sitprija V. Spelman JF, Peglow S, Schwartz AR, Burgo-Black L, Cross reactivity and lethality neutralization of venoms of McNamara K, Becker WC. Indonesian Trimeresurus complex species by Thai Green Group visits for overdose education and naloxone Pit Viper Antivenom. distribution in primary care: a pilot quality improvement Toxicon 2017; online early: initiative. doi: 10.1016/j.toxicon.2017.10.014: Pain Med 2017; online early: doi: 10.1093/pm/pnx243:

26

Epigallocatechin-3-gallate Urnoski E. Guvvala PR, Ravindra JP, Rajani CV, Sivaram M, Selvaraju S. Why is buprenorphine coformulated with naloxone? Protective role of epigallocatechin-3-gallate on arsenic J Am Acad Physician Assist 2017; 30: 44-5. induced testicular toxicity in Swiss albino mice.

Biomed Pharmacother 2017; 96: 685-94. Vengerovich NG, Yudin MA, Bykov VN, Nikiforov AS,

Aleshina OI, Kuz'min AA, Ustinova TM, Gadzikovskii SV. Analysis of the efficiency of microencapsulated sustained- Extracorporeal treatments release form of naloxone on the experimental model of Karaman K, Türkdogan KA, Deniz AT, Çanakçi SE. fentanyl poisoning. Which is the best in carbamazepine overdose? Bull Exp Biol Med 2017; online early: Clin Case Rep 2017; 5: 1612-5. doi: 10.1007/s10517-017-3892-x: Liu S, Xu L, Ma J, Huang R, Lin T, Li Z, Liang H, Li S, Li R, Silymarin Zhang L, Tao Y, Li Z, Chen Y, Ye Z, Zhang B, Wang W, Xiao Liu Z, Sun M, Wang Y, Zhang L, Zhao H, Zhao M. H, Liang X, Shi W. Silymarin attenuated paraquat-induced cytotoxicity in High-volume continuous venovenous hemodiafiltration macrophage by regulating Trx/TXNIP complex, inhibiting plus resin hemoperfusion improve severe metformin- NLRP3 inflammasome activation and apoptosis. associated toxicity. Toxicol In Vitro 2017; online early: J Diabetes Investig 2017; online early: doi: 10.1016/j.tiv.2017.10.017: doi: 10.1111/jdi.12757:

Alpha-lipoic acid El-Shenawy NS, Hamza RZ, Khaled HE. Ma Z, Liu Z, Wang Z, Ren S, Tang S, Wang Y-P, Xiao S, Protective effect of -lipoic acid against spleen toxicity of Chen C, Li W. dimethylnitrosamine in male mice: antioxidant and Supplementation of American ginseng berry extract ultrastructure approaches. mitigated cisplatin-evoked nephrotoxicity by suppressing Biomed Pharmacother 2017; 96: 459-65. ROS-mediated activation of MAPK and NF-kappaB signaling pathways. Food Chem Toxicol 2017; online early: Astaxanthin doi: 10.1016/j.fct.2017.10.006: El-Agamy SE, Abdel-Aziz AK, Wahdan S, Esmat A, Azab SS. Astaxanthin ameliorates doxorubicin-induced cognitive Tran T-V, Shin E-J, Dang D-K, Ko SK, Jeong JH, Nah S-Y, impairment (chemobrain) in experimental rat model: impact Jang C-G, Lee YJ, Toriumi K, Nabeshima T, Kim HC. on oxidative, inflammatory, and apoptotic machineries. Ginsenoside Re protects against -induced Mol Neurobiol 2017; online early: doi: 10.1007/s12035- behavioral changes and mitochondrial dysfunction via 017-0797-7: interactive modulation of glutathione peroxidase-1 and

NADPH oxidase in the dorsolateral cortex of mice. Baclofen Food Chem Toxicol 2017; online early: Larabi IA, Fabresse N, Knapp A, Forcet M, Baud FJ, doi: 10.1016/j.fct.2017.10.019: Grandmaison dlGL, Alvarez JC. LC-MS/MS method for quantification of baclofen in hair: a Insulin useful tool to assess compliance in alcohol dependent Page CB, Ryan NM, Isbister GK. patients? Drug Test Anal 2017; online early: doi: 10.1002/dta.2308: The safety of high-dose insulin euglycaemia therapy in toxin-induced cardiac toxicity.

Clin Toxicol 2017; online early: Buprenorphine doi: 10.1080/15563650.2017.1391391: Simon CB, Tsui JI, Merrill JO, Adwell A, Tamru E, Klein JW. Linking patients with buprenorphine treatment in primary care: Predictors of engagement. L-cysteine Drug Alcohol Depend 2017; 181: 58-62. Hamza RZ, El-Shenawy NS. The beneficial effects of L-cysteine on brain antioxidants Urnoski E. of rats affected by sodium valproate. Why is buprenorphine coformulated with naloxone? Hum Exp Toxicol 2017; 36: 1212-21. J Am Acad Physician Assist 2017; 30: 44-5. Loxapine Capsaicin Roncero C, Ros-Cucurull E, Palma-Álvarez RF, Abad AC, Koneru M, Sahu BD, Mir SM, Ravuri HG, Kuncha M, Fadeuilhe C, Casas M, Grau-López L. Mahesh KJ, Kilari EK, Sistla R. Inhaled loxapine for agitation in intoxicated patients: a Capsaicin, the pungent principle of peppers, ameliorates case series. alcohol-induced acute liver injury in mice via modulation of Clin Neuropharmacol 2017; online early: matrix metalloproteinases. doi: 10.1097/WNF.0000000000000252: Can J Physiol Pharmacol 2017; online early: doi: 10.1139/cjpp-2017-0473: Metallothionein Jing L, Yang M, Li Y, Yu Y, Liang B, Cao L, Zhou X, Peng Curcumin S, Sun Z. Mohajeri M, Behnam B, Cicero FG, Sahebkar A. Metallothionein prevents doxorubicin cardiac toxicity by Protective effects of curcumin against aflatoxicosis: a indirectly regulating the uncoupling proteins 2. comprehensive review. Food Chem Toxicol 2017; online early: J Cell Physiol 2017; online early: doi: 10.1002/jcp.26212: doi: 10.1016/j.fct.2017.10.035:

27

Methadone maintenance therapy Opioid maintenance therapy Ghaderi A, Motmaen M, Abdi I, Rasouli-Azad M. Bogen DL, Hanusa BH, Perel JM, Sherman F, Mendelson Gender differences in substance use patterns and MA, Wisner KL. disorders among an Iranian patient sample receiving Corrected QT interval and methadone dose and methadone maintenance treatment. concentrations in pregnant and postpartum women. Electron Physician 2017; 9: 5354-62. J Clin Psychiatry 2017; online early: doi: 10.4088/JCP.16m11318: Rozanova J, Marcus R, Taxman FS, Bojko MJ, Madden L, Farnum SO, Mazhnaya A, Dvoriak S, Altice FL. Haber PS, Elsayed M, Espinoza D, Lintzeris N, Veillard A-S, Why people who inject drugs voluntarily transition off Hallinan R. methadone in Ukraine. Constipation and other common symptoms reported by Qual Health Res 2017; online early: women and men in methadone and buprenorphine doi: 10.1177/1049732317732307: maintenance treatment. Drug Alcohol Depend 2017; 181: 132-9.

Metoclopramide Heidebrecht F, MacLeod MB, Dawkins L. Jaber BM, Petroianu GA, Rizvi SA, Borai A, Saleh NA, Hala Predictors of heroin abstinence in opiate substitution SM, Saleh AM. therapy in heroin-only users and dual users of heroin and Protective effect of metoclopramide against organo- crack. phosphate-induced apoptosis in the murine skin fibroblast Addict Behav 2017; 77: 210-6. L929. J Appl Toxicol 2017; online early: doi: 10.1002/jat.3543: Parran TV, Mace AG, Dahan YJ, Adelman CA, Kolganov M. Buprenorphine/naloxone maintenance therapy: an Naltrexone observational retrospective report on the effect of dose on Moerke MJ, Banks ML, Cheng K, Rice KC, Negus SS. 18 months retention in an office-based treatment program. Maintenance on naltrexone+ decreases Subst Abus 2017; 11: doi: 10.1177/1178221817731320. cocaine-vs.-food choice in male rhesus monkeys. Drug Alcohol Depend 2017; 181: 85-93. Progesterone Zaki SM, Ahmed EM, Motawie AG, Abdel FS. Tanum L, Solli KK, Latif ZE, Benth JŠ, Opheim A, Sharma- N-acetylcysteine versus progesterone on the cisplatin- Haase K, Krajci P, Kunøe N. induced peripheral neurotoxicity. The effectiveness of injectable extended-release naltrexone Folia Morphol (Praha) 2017; online early: vs daily buprenorphine-naloxone for opioid dependence: a doi: 10.5603/FM.a2017.0090: randomized clinical noninferiority trial. JAMA Psychiatry 2017; online early: Quercetin doi: 10.1001/jamapsychiatry.2017.3206: Andreucci M, Faga T, Pisani A, Serra R, Russo D, De Sarro G, Michael A. Nanoparticles Quercetin protects against radiocontrast medium toxicity Koide H, Tsuchida H, Nakamoto M, Okishima A, Ariizumi S, in human renal proximal tubular cells. Kiyokawa C, Asai T, Hoshino Y, Oku N. J Cell Physiol 2017; online early: doi: 10.1002/jcp.26213: Rational designing of an antidote nanoparticle decorated with abiotic polymer ligands for capturing and neutralizing Reactive skin decontamination lotion target toxins. Bogan R, Maas HJ, Zimmermann T. J Control Release 2017; online early: Chemical stability of reactive skin decontamination lotion doi: 10.1016/j.jconrel.2017.10.028: (RSDL®). Toxicol Lett 2017; online early: Nait Mohamed FA, Nouri A, Laraba-Djebari F. doi: 10.1016/j.toxlet.2017.09.016: Reactogenicity and safety assessment of an attenuated nanovaccine against scorpion envenomation: Preclinical study. Rutin Vaccine 2017; online early: Abarikwu SO, Njoku RC, Lawrence CJ, Charles IA, doi: 10.1016/j.vaccine.2017.10.028: Ikewuchi JC. Rutin ameliorates oxidative stress and preserves hepatic Rani V, Verma Y, Rana K, Rana SVS. and renal functions following exposure to cadmium and Zinc oxide nanoparticles inhibit dimethylnitrosamine induced ethanol. liver injury in rat. Pharm Biol 2017; 55: 2161-9. Chem Biol Interact 2017; online early: doi: 10.1016/j.cbi.2017.10.009: Uridine triacetate Zhu Y, Deng G, Ji A, Yao J, Meng X, Wang J, Wang Q, Oliver WD, Duffy AP, Hausner PF. Wang Q, Wang R. Case report of capecitabine toxicity and use of uridine triacetate. Porous Se@SiO nanospheres treated paraquat-induced 2 J Oncol Pharm Pract 2017; online early: acute lung injury by resisting oxidative stress. doi: 10.1177/1078155217730662: Int J Nanomedicine 2017; 12: 7143-52.

Oleracein E DRUGS Li L, Jiao Y, Jin T, Sun H, Li S, Jin C, Hu S, Ji J, Xiang L. General Phenolic alkaloid oleracein E attenuates oxidative stress Alvarez JC, Lasne L, Etting I, Cheron G, Abadie V, and neurotoxicity in AlCl3-treated mice. Fabresse N, Larabi IA. Life Sci 2017; online early: doi: 10.1016/j.lfs.2017.10.019: Hair analysis does not allow to discriminate between acute and chronic administrations of a drug in young children.

28

Int J Legal Med 2017; online early: doi: 10.1007/s00414- Severe physical complications among survivors of Stevens- 017-1720-5: Johnson syndrome and toxic epidermal necrolysis. Drug Saf 2017; online early: doi: 10.1007/s40264-017- Antunes MM, Araújo AM, Diniz AB, Pereira RVS, Alvarenga 0608-0: DM, David BA, Rocha RM, Lopes MAF, Marchesi SC, Nakagaki BN, Carvalho E, Marques PE, Ryffel B, Quesniaux Orsini J, Din N, Elahi E, Gomez A, Rajayer S, Malik R, Jean E. V, Brito RG, Filho JCA, Cara DC, Rezende RM, Menezes GB. Clinical and epidemiological characteristics of patients with IL-33 signalling in liver immune cells enhances drug- acute drug intoxication admitted to ICU. induced liver injury and inflammation. J Community Hosp Intern Med Perspect 2017; 7: 202-7. Inflamm Res 2017; online early: doi: 10.1007/s00011- 017-1098-3: Ostermann M, Chawla LS, Forni LG, Kane-Gill SL, Kellum JA, Koyner J, Murray PT, Ronco C, Goldstein SL, ADQI 16 Austin AE, Proescholdbell SK, Creppage KE, Asbun A. workgroup. Characteristics of self-inflicted drug overdose deaths in Drug management in acute kidney disease – Report of the North Carolina. ADQI XVI meeting. Drug Alcohol Depend 2017; 181: 44-9. Br J Clin Pharmacol 2017; online early: doi: 10.1111/bcp.13449: Bartoli C, Berland-Benhaim C, Tuchtan-Torrents L, Kintz P, Leonetti G, Pelissier-Alicot A-L. Pavlos R, White KD, Wanjalla C, Mallal SA, Phillips EJ. Suicide by medication overdose in prison: a study of three Severe delayed drug reactions: role of genetics and viral cases. infections. J Forensic Sci 2017; online early: doi: 10.1111/1556- Immunol Allergy Clin North Am 2017; 37: 785-815. 4029.13671: Rayburn ER, Gao L, Ding J, Ding H, Shao J, Li H. Boland MR, Polubriaginof F, Tatonetti NP. FDA-approved drugs that are spermatotoxic in animals Development of a machine learning algorithm to classify and the utility of animal testing for human risk prediction. drugs of unknown fetal effect. J Assist Reprod Genet 2017; online early: Sci Rep 2017; 7: 12839. doi: 10.1007/s10815-017-1062-8:

Ching CK, Chen SPL, Lee HHC, Lam YH, Ng SW, Chen ML, Rönkä S, Karjalainen K, Martikainen P, Mäkelä P. Tang MHY, Chan SSS, Ng CWY, Cheung JWL, Chan TYC, Social determinants of drug-related mortality in a general Lau NKC, Chong YK, Mak TWL. population. Adulteration of proprietary Chinese medicines and health Drug Alcohol Depend 2017; 181: 37-43. products with undeclared drugs: experience of a tertiary toxicology laboratory in Hong Kong. Ryu B, Kim C-Y, Oh H, Kim U, Kim J, Jung C-R, Lee B-H, Br J Clin Pharmacol 2017; online early: Lee S, Chang S-N, Lee JM, Chung H-M, Park J-H. Development of an alternative zebrafish model for drug- doi: 10.1111/bcp.13420: induced intestinal toxicity.

J Appl Toxicol 2017; online early: doi: 10.1002/jat.3520: Dathe K, Schaefer C.

Drug safety in pregnancy: the German Embryotox institute. Saheb Sharif-Askari F, Saheb Sharif-Askari N, Javadi M, Eur J Clin Pharmacol 2017; online early: Gholami K. doi: 10.1007/s00228-017-2351-y: Adverse drug reactions reported to the drug and poison

information center of Tehran, Iran. Dowell D, Noonan RK, Houry D. PLoS ONE 2017; 12: e0185450. Underlying factors in drug overdose deaths. JAMA 2017; online early: doi: 10.1001/jama.2017.15971: Sanz F, Pognan F, Steger-Hartmann T, Díaz C, Cases M, Pastor M, Marc P, Wichard J, Briggs K, Watson DK, Kleinöder Insel PA, Amara SG, Blaschke TF, Meyer UA. T, Yang C, Amberg A, Beaumont M, Brookes AJ, Brunak S, Introduction to the Theme "New approaches for studying Cronin MTD, Ecker GF, Escher S, Greene N, Guzmán A, drug and toxicant action: applications to drug discovery Hersey A, Jacques P, Lammens L, Mestres J, Muster W, and development". Northeved H, Pinches M, Saiz J, Sajot N. Annu Rev Pharmacol Toxicol 2018; online early: doi: Legacy data sharing to improve drug safety assessment: 10.1146/annurev-pharmtox-092617-121952: the eTOX project. Nat Rev Drug Discov 2017; online early: Lei T, Sun H, Kang Y, Zhu F, Liu H, Zhou W, Wang Z, Li D, doi: 10.1038/nrd.2017.177: Li Y, Hou T. ADMET evaluation in drug discovery. 18. Reliable Sellers EM, Romach MK. prediction of chemical-induced urinary tract toxicity by Categorization of abuse potential-related adverse events. boosting machine learning approaches. Clin Pharmacol Drug Dev 2017; online early: Mol Pharm 2017; online early: doi: 10.1002/cpdd.394: doi: 10.1021/acs.molpharmaceut.7b00631: Snodin DJ. Mitchell KJ, Nolte K, Turner HA, Hamby S, Jones LM. The cancer threshold of toxicological concern (TTC) in Exposure to medication overdose as an adversity in relation to foodstuffs and pharmaceuticals: a potentially childhood. useful concept compromised by a dubious derivation. J Pediatr Nurs 2017; online early: Hum Exp Toxicol 2017; online early: doi: 10.1016/j.pedn.2017.09.006: doi: 10.1177/960327117735571:

Olteanu C, Shear NH, Chew HF, Hashimoto R, Alhusayen Yang C-A, Liu H-C, Lin D-L, Liu RH, Hsieh Y-Z, Wu S-P. R, Whyte-Croasdaile S, Finkelstein Y, Burnett M, Ziv M, Simultaneous quantitation of methamphetamine, ketamine, Sade S, Jeschke MG, Dodiuk-Gad RP. opiates and their metabolites in urine by SPE and LC-MS-MS.

29

J Anal Toxicol 2017; online early: doi: 10.1093/jat/bkx057: Sevoflurane Goyagi T. Zhang H, Yu P, Ren J-X, Li X-B, Wang H-L, Ding L, Kong W-B. Long-duration sevoflurane exposure with the normoxic Development of novel prediction model for drug-induced carrier gas increase the neural apoptosis and impair the mitochondrial toxicity by using naive Bayes classifier method. long-term cognitive function in neonatal rats. Food Chem Toxicol 2017; online early: Brain Res Rev 2017; online early: doi: 10.1016/j.fct.2017.10.021: doi: 10.1016/j.brainres.2017.10.014:

Zheng WY, Richardson LC, Li L, Day RO, Westbrook JI, Baysari MT. Anorexiant drugs Drug-drug interactions and their harmful effects in Leone O, Agostini V, Foà A, Cerbelli B, di Gioia CRT, hospitalised patients: a systematic review and meta-analysis. Aromatario M, Ciallella C, Lucena J, d'Amati G. Eur J Clin Pharmacol 2017; online early: Cardiac pathologic findings in three unusual cases of doi: 10.1007/s00228-017-2357-5: sudden cardiac death related to anorexiant drugs. Hum Pathol 2017; online early: doi: 10.1016/j.humpath.2017.09.014: Acetaminophen (see paracetamol) Antiarrhythmic drugs Acetylcysteine Personne M. Amiodarone A 10-fold bolus dose of N-acetylcysteine with fatal conse- Colby R, Geyer H. quences. Amiodarone-induced pulmonary toxicity. Clin Toxicol 2017; online early: J Am Acad Physician Assist 2017; 30: 23-6. doi: 10.1080/15563650.2017.1394466: Liao R, Yan F, Zeng Z, Wang H, Qiu K, Xu J, Zheng W. IGF-1 activates PI3K/Akt signaling to protect human Amfetamines and MDMA (ecstasy) retinal pigment epithelial cells from amiodarone-induced Borg D, Kolb E, Lantigua C, Stripp R. oxidative injury. Chiral analysis of methamphetamine in oral fluid samples: Br J Pharmacol 2017; online early: doi: 10.1111/bph.14078: a method to distinguish licit from illicit drug use. J Anal Toxicol 2017; online early: doi: 10.1093/jat/bkx079: Antibiotics Moerke MJ, Banks ML, Cheng K, Rice KC, Negus SS. Tajmir-Riahi A, Wörl P, Harrer T, Schliep S, Schuler G, Maintenance on naltrexone+amphetamine decreases Simon M. cocaine-vs.-food choice in male rhesus monkeys. Life-threatening atypical case of acute generalized Drug Alcohol Depend 2017; 181: 85-93. exanthematous pustulosis. Int Arch Allergy Immunol 2017; 174: 108-11. Vevelstad M, Oiestad EL, Nerem E, Arnestad M, Bogen IL. Studies on para-methoxymethamphetamine (PMMA) Aminoglycosides metabolite pattern and influence of CYP2D6 genetics in Jiang M, Karasawa T, Steyger PS. human liver microsomes and authentic samples from fatal Aminoglycoside-induced cochleotoxicity: a review. PMMA intoxications. Front Cell Neurosci 2017; 11: 308. Drug Metab Dispos 2017; online early: doi: 10.1124/dmd.117.077263: Polymyxin B John JF, Falci DR, Rigatto MH, Oliveira RD, Kremer TG, Anaesthetics Zavascki AP. Jacob JS, Kovac AL. Severe infusion-related adverse events and renal failure in Procaine and local anesthetic toxicity: a collaboration patients receiving high-dose intravenous polymyxin B. between the clinical and basic sciences. Antimicrob Agents Chemother 2017; online early: doi: Reg Anesth Pain Med 2017; online early: 10.1128/AAC.01617-17: doi: 10.1097/AAP.0000000000000664: Anticoagulants Articaine Kaatz S, Mahan CE, Nakhle A, Gunasekaran K, Ali M, Hopman AJG, Baart JA, Brand HS. Lavender R, Paje DG. Articaine and neurotoxicity - a review. Management of elective surgery and emergent bleeding Br Dent J 2017; online early: doi: 10.1038/sj.bdj.2017.782: with direct oral anticoagulants. Curr Cardiol Rep 2017; 19: 124. Propofol Procaccianti P, Farè F, Argo A, Casagni E, Arnoldi S, Levine M, Beuhler MC, Pizon A, Cantrel FL, Spyres MB, Facheris S, Visconti GL, Roda G, Gambaro V. LoVecchio F, Skolnik AB, Brooks DE. Determination of propofol by GC/MS and fast GC/MS-TOF Assessing bleeding risk in patients with intentional overdoses in two cases of poisoning. of novel antiplatelet and anticoagulant medications. J Anal Toxicol 2017; online early: doi: 10.1093/jat/bkx056: Ann Emerg Med 2017; online early: doi: 10.1016/j.annemergmed.2017.08.046: Yan Y, Qiao S, Kikuchi C, Zaja I, Logan S, Jiang C, Arzua T, Bai X. Apixaban Propofol induces apoptosis of neurons but not astrocytes, Ilicki J, Höjer J, Djärv T. oligodendrocytes, or neural stem cells in the neonatal Massive apixaban overdose - a comparison of three cases. mouse hippocampus. Am J Emerg Med 2017; online early: Brain Sci 2017; 7: 130. doi: 10.1016/j.ajem.2017.09.035:

30

Mast L, Verheul RJ, Reijnen R, van Rossen RCJM, Overdiek JWPM, Wilms EB. Valproate Apixaban auto-intoxication: toxicokinetics and coagulation Hamza RZ, El-Shenawy NS. tests. The beneficial effects of L-cysteine on brain antioxidants Thromb Haemost 2017; online early: doi: 10.1160/TH17- of rats affected by sodium valproate. 07-0474: Hum Exp Toxicol 2017; 36: 1212-21.

Dabigatran Muñiz AE. Yip L, Deng J-F. Valproic acid overdose review of a case with electro- The recommended dose of idarucizumab may not always be cardiographic changes. sufficient for sustained reversal of dabigatran: comment. J Emerg Med 2017; 53: 333-8. J Thromb Haemost 2017; online early: doi: 10.1111/jth.13854: Patrick KA, Jarriel JT, Hieger MA. Pancreatic pseudocyst due to acute valproic acid Heparin overdose. Am J Ther 2017; online early: Hassanian-Moghaddam H, Bahrami-Motlagh H, Zamani N, doi: 10.1097/MJT.0000000000000684: Fazeli SA, Behnam B.

Intracranial hemorrhage in methanol toxicity: challenging the probable heparin effect during hemodialysis. Shona SI, Rizk AA, El Sadik AO, Emam HY, Ali EN. Effect of valproic acid administration during pregnancy on J Res Pharm Pract 2017; 6: 186-9. postnatal development of cerebellar cortex and the

possible protective role of folic acid. Anticonvulsants Folia Morphol (Praha) 2017; online early: De Luca F, Losappio LM, Mirone C, Schroeder JW, Citterio doi: 10.5603/FM.a2017.0100: A, Aversano MG, Scibilia J, Pastorello EA. Tolerated drugs in subjects with severe cutaneous adverse Verma T, Mallik SB, Ramalingayya GV, Nayak PG, Kishore reactions (SCARs) induced by anticonvulsants and review A, Pai KSR, Nandakumar K. of the literature. Sodium valproate enhances doxorubicin-induced cognitive Clin Mol Allergy 2017; 15: 16. dysfunction in Wistar rats. Biomed Pharmacother 2017; 96: 736-41. Frey N, Bodmer M, Bircher A, Ruegg S, Jick SS, Meier CR, Spoendlin J. Antifungal drugs The risk of Stevens-Johnson syndrome and toxic Amsden JR, Gubbins PO. epidermal necrolysis in new users of antiepileptic drugs. Pharmacogenomics of triazole antifungal agents: Epilepsia 2017; online early: doi: 10.1111/epi.13925: implications for safety, tolerability and efficacy.

Expert Opin Drug Metab Toxicol 2017; online early: doi: Carbamazepine 10.1080/17425255.2017.1391213: Karaman K, Türkdogan KA, Deniz AT, Çanakçi SE. Which is the best in carbamazepine overdose? Antimalarial drugs Clin Case Rep 2017; 5: 1612-5. Hydroxychloroquine Yuliwulandari R, Kristin E, Prayuni K, Sachrowardi Q, Stern EM, Johnson JS, Mazzulla DA. Suyatna FD, Menaldi SL, Wichukchinda N, Mahasirimongkol Highly accelerated onset of hydroxychloroquine macular S, Cavallari LH. retinopathy. Association of the HLA-B alleles with carbamazepine-induced Ochsner J 2017; 17: 280-3. Stevens-Johnson syndrome/toxic epidermal necrolysis in the Javanese and Sundanese population of Indonesia: the Antineoplastic drugs important role of the HLA-B75 serotype. Di Cesare ML, Maresca M, Micheli L, Farina C, Scherz MW, Pharmacogenomics 2017; online early: doi: 10.2217/pgs- Ghelardini C. 2017-0103: A rat model of FOLFOX-induced neuropathy: effects of oral dimiracetam in comparison with duloxetine and Gabapentin pregabalin. Bonnet U, Scherbaum N. Cancer Chemother Pharmacol 2017; online early: doi: How addictive are gabapentin and pregabalin? A systematic 10.1007/s00280-017-3449-8: review. Eur Neuropsychopharmacol 2017; online early: Heidari-Soreshjani S, Asadi-Samani M, Yang Q, Saeedi- doi: 10.1016/j.euroneuro.2017.08.430: Boroujeni A. Phytotherapy of nephrotoxicity-induced by cancer drugs: Pregabalin an updated review. J Nephropathol 2017; 6: 254-63. Bonnet U, Scherbaum N. How addictive are gabapentin and pregabalin? A systematic Ledda A, Belcaro G, Dugall M, Luzzi R, Hosoi M, Feragalli review. B, Cotellese R, Cosentino V, Cosentino M, Eggenhoffner R, Eur Neuropsychopharmacol 2017; online early: doi: Pellizzato M, Fratter A, Giacomelli L. 10.1016/j.euroneuro.2017.08.430: A natural pharma standard supplement formulation to control treatment-related toxicity and oxidative stress in Topiramate genitourinary cancer: a preliminary study. Khivsara A, Raj JP, Hegde D, Rao M. Eur Rev Med Pharmacol Sci 2017; 21: 4196-202. Topiramate-induced acute liver injury: a rare adverse effect. Ly A, Cheng HH, Alwan L. Indian J Pharmacol 2017; 49: 254-6. Hepatitis C infection and chemotherapy toxicity.

31

J Oncol Pharm Pract 2017; online early: Concurrent radiotherapy with temozolomide vs. concurrent doi: 10.1177/1078155217734626: radiotherapy with a cisplatinum-based polychemotherapy regimen : acute toxicity in pediatric high-grade glioma Morita M, Kishi S, Ookura M, Matsuda Y, Tai K, Yamauchi T, patients. Ueda T. Strahlenther Onkol 2017; online early: Efficacy of aprepitant for CHOP chemotherapy-induced doi: 10.1007/s00066-017-1218-6: nausea, vomiting, and anorexia. Curr Probl Cancer 2017; online early: Zaki SM, Ahmed EM, Motawie AG, Abdel FS. doi: 10.1016/j.currproblcancer.2017.09.001: N-acetylcysteine versus progesterone on the cisplatin- induced peripheral neurotoxicity. Shah C, Gong Y, Szady A, Sun Q, Pepine CJ, Langaee T, Folia Morphol (Praha) 2017; online early: Lucas AR, Moreb JS. doi: 10.5603/FM.a2017.0090: Unanticipated Cardiotoxicity Associated with Targeted Anticancer Therapy in Patients with Hematologic Malignancies Cyclophosphamide Patients: Natural History and Risk Factors. Onaolapo AY, Oladipo BP, Onaolapo OJ. Cardiovasc Toxicol 2017; online early: Cyclophosphamide-induced male subfertility in mice: an doi: 10.1007/s12012-017-9429-8: assessment of the potential benefits of Maca supplement.

Andrologia 2017; online early: doi: 10.1111/and.12911: Zukas AM, Schiff D.

Neurological complications of new chemotherapy agents. Neuro Oncol 2017; online early: Dacarbazine doi: 10.1093/neuonc/nox115: Binaghi G, Congia D, Cossa S, Massidda S, Pasqualucci D, Pilo F, Serra E, Angelucci E, Porcu M. Capecitabine Cardiogenic shock during first infusion of anthracycline chemotherapy in a patient with Hodgkin lymphoma: an Oliver WD, Duffy AP, Hausner PF. unusual event. Case report of capecitabine toxicity and use of uridine Cardiology 2018; 139: 7-10. triacetate.

J Oncol Pharm Pract 2017; online early: doi: 10.1177/1078155217730662: Doxorubicin El-Agamy SE, Abdel-Aziz AK, Wahdan S, Esmat A, Azab SS. Cisplatin Astaxanthin ameliorates doxorubicin-induced cognitive impairment (chemobrain) in experimental rat model: impact Cao SS, Yan M, Hou ZY, Chen Y, Jiang YS, Fan XR, Fang on oxidative, inflammatory, and apoptotic machineries. PF, Zhang Bk. Mol Neurobiol 2017; online early: doi: 10.1007/s12035- Danshen modulates Nrf2-mediated signaling pathway in 017-0797-7: cisplatin-induced renal injury.

J Huazhong Univ Sci Technol Med Sci 2017; 37: 761-5. Jing L, Yang M, Li Y, Yu Y, Liang B, Cao L, Zhou X, Peng S,

Sun Z. Chen Y, Dale Thurman J, Kinter LB, Bialecki R, Eric Metallothionein prevents doxorubicin cardiac toxicity by McDuffie J. indirectly regulating the uncoupling proteins 2. Perspectives on using a multiplex human kidney safety Food Chem Toxicol 2017; online early: biomarker panel to detect cisplatin-induced tubular toxicity doi: 10.1016/j.fct.2017.10.035: in male and female Cynomolgus monkeys.

Toxicol Appl Pharmacol 2017; online early: Lin E-Y, Bayarsengee U, Wang C-C, Chiang Y-H, Cheng C-W. doi: 10.1016/j.taap.2017.10.010: The natural compound 2,3,5,4'-tetrahydroxystilbene-2-O-

beta-d glucoside protects against adriamycin-induced Cheng T-C, Hsu Y-W, Lu F-J, Chen Y-Y, Tsai N-M, Chen nephropathy through activating the Nrf2-Keap1 antioxidant W-K, Tsai C-F. pathway. Nephroprotective effect of electrolyzed reduced water Environ Toxicol 2017; online early: doi: 10.1002/tox.22496: against cisplatin-induced kidney toxicity and oxidative damage in mice. Verma T, Mallik SB, Ramalingayya GV, Nayak PG, Kishore J Chin Med Assoc 2017; online early: A, Pai KSR, Nandakumar K. doi: 10.1016/j.jcma.2017.08.014: Sodium valproate enhances doxorubicin-induced cognitive

dysfunction in Wistar rats. Ma Z, Liu Z, Wang Z, Ren S, Tang S, Wang Y-P, Xiao S, Biomed Pharmacother 2017; 96: 736-41. Chen C, Li W.

Supplementation of American ginseng berry extract mitigated cisplatin-evoked nephrotoxicity by suppressing Yang FO, Hsu NC, Moi SH, Lu YC, Hsieh CM, Chang KJ, ROS-mediated activation of MAPK and NF-kappaB Chen DR, Tu CW, Wang HC, Hou MF. signaling pathways. Efficacy and toxicity of pegylated liposomal doxorubicin- Food Chem Toxicol 2017; online early: based chemotherapy in early-stage breast cancer: a doi: 10.1016/j.fct.2017.10.006: multicenter retrospective case-control study. Asia Pac J Clin Oncol 2017; online early: Pezeshki Z, Khosravi A, Nekuei M, Khoshnood S, Zandi E, doi: 10.1111/ajco.12771: Eslamian M, Talebi A, Emami SNed, Nematbakhsh M. Time course of cisplatin-induced nephrotoxicity and Erlotinib hepatotoxicity. Fiala O, Hosek P, Pesek M, Finek J, Racek J, Stehlik P, J Nephropathol 2017; 6: 163-7. Sorejs O, Minarik M, Benesova L, Celer A, Nemcova I, Kucera R, Topolcan O. Seidel C, von Bueren AO, Bojko S, Hoffmann M, Pietsch T, Serum concentration of erlotinib and its correlation with Gielen GH, Warmuth-Metz M, Bison B, Kortmann RD, outcome and toxicity in patients with advanced-stage NSCLC. Kramm CM. Anticancer Res 2017; 37: 6469-76.

32

Clin Toxicol 2017; online early: Ifosfamide doi: 10.1080/15563650.2017.1388385: Sannu A, Radha R, Mathews A, Padmakumari MR, Prahladan A, James FV. Clozapine Ifosfamide-induced malignancy of ureter and bladder. Joy G, Whiskey E, Bolstridge M, Porras-Segovia A, Cureus 2017; 9: e1594. McDonagh TA, Plymen CM, Shergill SS. Hearts and minds: real-life cardiotoxicity with clozapine in Irinotecan psychosis. Fukuda M, Okumura M, Iwakiri T, Arimori K, Honda T, J Clin Psychopharmacol 2017; online early: Kobayashi K, Senju H, Takemoto S, Ikeda T, Yamaguchi H, doi: 10.1097/JCP.0000000000000792: Nakatomi K, Matsuo N, Mukae H, Ashizawa K. Relationship between UGT1A1*27 and UGT1A1*7 poly- Antiviral drugs morphisms and irinotecan-related toxicities in patients Yang YM, Choi EJ. with lung cancer. Renal safety of tenofovir and/or entecavir in patients with Thoracic Cancer 2017; online early: doi: 10.1111/1759- chronic HBV monoinfection. 7714.12535: Ther Clin Risk Manag 2017; 13: 1273-85.

Nedaplatin Dolutegravir Song YJ, Fan T, Quan CY, Cao SH, Zhang Y, Shao XH. Wang B, Abbott L, Childs K, Taylor C, Agarwal K, Cormack Nedaplatin-induced arrhythmia: retrospective analysis of I, Miquel R, Suddle A. three cases. Dolutegravir-induced liver injury leading to sub-acute liver J Coll Physicians Surg Pak 2017; 27: 657-9. failure requiring transplantation: a case report and review of literature. Olaparib Int J STD AIDS 2017; online early: Dockery LE, Tew WP, Ding K, Moore KN. doi: 10.1177/0956462417734099: Tolerance and toxicity of the PARP inhibitor olaparib in older women with epithelial ovarian cancer. Baclofen Gynecol Oncol 2017; online early: Léger M, Brunet M, Le Roux G, Lerolle N, Boels D. doi: 10.1016/j.ygyno.2017.10.007: Baclofen self-poisoning in the era of changing indication: multicentric reports to a French Poison Control Centre. Oxaliplatin Alcohol Alcohol 2017; online early: Nishida K, Kashiwagi M, Shiba S, Muroki K, Ohishi A, Doi doi: 10.1093/alcalc/agx072: Y, Ando H, Ishida T, Nagasawa K. Liposomalization of oxaliplatin induces skin accumulation Benzbromarone of it, but negligible skin toxicity. Wang H, Peng Y, Zhang T, Lan Q, Zhao H, Wang W, Zhao Toxicol Appl Pharmacol 2017; online early: Y, Wang X, Pang J, Wang S, Zheng J. doi: 10.1016/j.taap.2017.10.006: Metabolic epoxidation is a critical step for the development

of benzbromarone-induced hepatotoxicity. Temozolomide Drug Metab Dispos 2017; online early: Seidel C, von Bueren AO, Bojko S, Hoffmann M, Pietsch T, doi: 10.1124/dmd.117.077818: Gielen GH, Warmuth-Metz M, Bison B, Kortmann RD, Kramm CM. Concurrent radiotherapy with temozolomide vs. concurrent Beta-blockers radiotherapy with a cisplatinum-based polychemotherapy Canfield DV, Dubowski KM, Whinnery JM, Forster EM. regimen : acute toxicity in pediatric high-grade glioma Pilot-reported beta-lockers identified by forensic toxicology patients. analysis of postmortem specimens. Strahlenther Onkol 2017; online early: J Anal Toxicol 2017; online early: doi: 10.1093/jat/bkx076: doi: 10.1007/s00066-017-1218-6: Treosulfan Liu H-X, Hou L-F, Chen T, Qu W, Liu S, Yan H, Wen X, Ping J. van der Stoep MYEC, Bertaina A, Ten Brink MH, Bredius RG, Prenatal caffeine ingestion increases susceptibility to Smiers FJ, Wanders DCM, Moes DJAR, Locatelli F, Guchelaar pulmonary inflammation in adult female rat offspring. H-J, Zwaveling J, Lankester AC. Reprod Toxicol 2017; online early: High interpatient variability of treosulfan exposure is doi: 10.1016/j.reprotox.2017.10.006: associated with early toxicity in paediatric HSCT: a prospective multicentre study. Cannabis (marijuana) Br J Haematol 2017; online early: doi: 10.1111/bjh.14960: Meehan-Atrash J, Luo W, Strongin RM. Toxicant formation in dabbing: the terpene story. Antipsychotics ACS Omega 2017; 2: 6112-7. Nikolic T, Petronijevic M, Sopta J, Velimirovic M, Stojkovic T, Jevtic Dozudic G, Aksic M, Radonjic NV, Petronijevic N. Sokoya M, Eagles J, Okland T, Coughlin D, Dauber H, affects bones while clozapine alters metabolic Greenlee C, Winkler AA. parameters – sex specific effects in rats perinatally treated Patterns of facial trauma before and after legalization of with phencyclidine. marijuana in Denver, Colorado: a joint study between two BMC Pharmacol Toxicol 2017; 18: 65. Denver hospitals. Am J Emerg Med 2017; online early: Stassinos G, Klein-Schwartz W. doi: 10.1016/j.ajem.2017.10.014: Asenapine, iloperidone and lurasidone exposures in young children reported to U.S. poison centers. Thomas AA, Mazor S.

33

Unintentional marijuana exposure presenting as altered Cytotoxic drugs mental status in the pediatric emergency department: a Bautista F, Moreno L, Marshall L, Pearson ADJ, Geoerger case series. B, Paoletti X. J Emerg Med 2017; online early: Revisiting the definition of dose-limiting toxicities in doi: 10.1016/j.jemermed.2017.08.007: paediatric oncology phase I clinical trials: an analysis from the Innovative Therapies for Children with Cancer Vyas MB, LeBaron VT, Gilson AM. Consortium. The use of cannabis in response to the opioid crisis: a Eur J Cancer 2017; 86: 275-84. review of the literature. Nurs Outlook 2017; online early: Dextromethorphan doi: 10.1016/j.outlook.2017.08.012: Cornthwaite HM, Labine L, Watterson JH.

Semi-quantitative analysis of tramadol, dextromethorphan Wu F, Scroggin TL, Metz TD, McMillin GA. and metabolites in decomposed skeletal tissues by ultra Development of a liquid chromatography-tandem mass performance liquid chromatography quadrupole time of spectrometry method for the simultaneous determination flight mass spectrometry (UPLC-qTOF-MS). of four cannabinoids in umbilical cord tissue. Drug Test Anal 2017; online early: doi: 10.1002/dta.2327: J Anal Toxicol 2017; online early: doi: 10.1093/jat/bkx078:

Estrogen Catecholamines Çelik C, Carus M, Büyükcam F. Okada Y, Ishi W, Narumiya H, Liduka R. Pulmonary embolism due to exogenous estrogen Unexpected hypotension in catecholamine reversal: a case intoxication. report. Am J Emerg Med 2017; online early: J Med Case Rep 2017; 11: 285. doi: 10.1016/j.ajem.2017.07.084:

Cocaine Martinez-Pinto J, Piquer B, Tiszavari M, Lara HE. Maza-Quiroga R, García-Marchena N, Romero-Sanchiz P, Neonatal exposure to estradiol valerate reprograms the rat Barrios V, Pedraz M, Serrano A, Nogueira-Arjona R, Ruiz ovary androgen receptor and anti-Mullerian hormone to a JJ, Soria M, Campos R, Chowen JA, Argente J, Torrens M, polycystic ovary phenotype. López-Gallardo M, Marco EM, Rodríguez de Fonseca F, Reprod Toxicol 2017; online early: Pavón FJ, Araos P. doi: 10.1016/j.reprotox.2017.10.005: Evaluation of plasma cytokines in patients with cocaine use disorders in abstinence identifies transforming growth factor Gamma hydroxybutyrate alpha (TGF) as a potential biomarker of consumption and Vogel KR, Ainslie GR, McConnell A, Roullet J-B, Gibson KM. dual diagnosis. Toxicologic/transport properties of NCS-382, a -hydroxy- PeerJ 2017; 5: e3926. butyrate (GHB) receptor ligand, in neuronal and epithelial cells: therapeutic implications for SSADH deficiency, a GABA Moerke MJ, Banks ML, Cheng K, Rice KC, Negus SS. metabolic disorder. Maintenance on naltrexone+amphetamine decreases Toxicol In Vitro 2018; 46: 203-12. cocaine-vs.-food choice in male rhesus monkeys. Drug Alcohol Depend 2017; 181: 85-93. Ginseng

Seo HW, Suh JH, So S-H, Kyung J-S, Kim Y-S, Han C-K. Musshoff F, Thieme D, Schwarz G, Sachs H, Skopp G, Subacute oral toxicity and bacterial mutagenicity study of Franz T. Korean Red Ginseng oil. Determination of hydroxy metabolites of cocaine in hair J Ginseng Res 2017; 41: 595-601. samples for proof of consumption.

Drug Test Anal 2017; online early: doi: 10.1002/dta.2317: Herbal medicines, ethnic remedies Colchicine and dietary supplements Haj Yahia S, Ben Zvi I, Livneh A. Brown AC. Colchicine intoxication in familial Mediterranean fever Heart toxicity related to herbs and dietary supplements: patients using clarithromycin for the treatment of online table of case reports. part 4 of 5. Helicobacter pylori: a series of six patients. J Diet Suppl 2017; online early: Rheumatol Int 2017; online early: doi: 10.1007/s00296- doi: 10.1080/19390211.2017.1356418: 017-3823-1: Cai Y, Sun W, Zhang X, Lin Y, Chen H, Li H. Indraratna PL, Virk S, Gurram D, Day RO. Osthole prevents acetaminophen-induced liver injury in mice. Use of colchicine in pregnancy: a systematic review and Acta Pharmacol Sin 2017; online early: meta-analysis. doi: 10.1038/aps.2017.129: Rheumatology (Oxford) 2017; online early: doi: 10.1093/rheumatology/kex353: Ching CK, Chen SPL, Lee HHC, Lam YH, Ng SW, Chen ML, Tang MHY, Chan SSS, Ng CWY, Cheung JWL, Chan TYC,

Lau NKC, Chong YK, Mak TWL. Corticosteroids Adulteration of proprietary Chinese medicines and health Rice JB, White AG, Scarpati LM, Wan G, Nelson WW. products with undeclared drugs: experience of a tertiary Long-term systemic corticosteroid exposure: a systematic toxicology laboratory in Hong Kong. literature review. Br J Clin Pharmacol 2017; online early: Clin Ther 2017; online early: doi: 10.1111/bcp.13420: doi: 10.1016/j.clinthera.2017.09.011: Cohen PA, Travis JC, Keizers PHJ, Deuster P, Venhuis BJ.

34

Four experimental stimulants found in sports and weight loss Adverse drug effects observed with vildagliptin versus supplements: 2-amino-6-methylheptane (octodrine), 1,4- pioglitazone or rosiglitazone in the treatment of patients dimethylamylamine (1,4-DMAA), 1,3-dimethylamylamine (1,3- with type 2 diabetes mellitus: a systematic review and DMAA) and 1,3-dimethylbutylamine (1,3-DMBA). meta-analysis of randomized controlled trials. Clin Toxicol 2017; online early: BMC Pharmacol Toxicol 2017; 18: 66. doi: 10.1080/15563650.2017.1398328: Immunoglobulins Lasoff DR, Cantrell FL, Ly BT. Arikapudi S, Rashid S, Al Almomani LA, Treece J, Death associated with intravenous turmeric (Curcumin) Baumrucker SJ. preparation. Serum bovine immunoglobulin for chemotherapy-induced Clin Toxicol 2017; online early: gastrointestinal mucositis. doi: 10.1080/15563650.2017.1388387: Am J Hosp Palliat Med 2017; online early: doi: 10.1177/1049909117735831: Lin L, Li H, Lin H, Zhang M, Qu C, Yan L, Yin X, Ni J. Application of iTRAQ-based quantitative proteomics approach Immunomodulatory drugs to identify deregulated proteins associated with liver toxicity Fradley MG, Groarke JD, Laubach J, Alsina M, Lenihan DJ, Induced by Polygonum multiflorum in rats. Cornell RF, Maglio M, Shain KH, Richardson PG, Moslehi J. Cell Physiol Biochem 2017; 43: 2102-16. Recurrent cardiotoxicity potentiated by the interaction of proteasome inhibitor and immunomodulatory therapy for Mahdavi ZK, Narayan R, Mainali S, Greenberg BM, Aiyagari the treatment of multiple myeloma. V, McDonagh DL. Br J Haematol 2017; online early: A callosal catastrophe: toxic leukoencephalopathy associated doi: 10.1111/bjh.14970: with thermogenic weight loss supplement use. Neurocrit Care 2017; online early: doi: 10.1007/s12028- Ivermectin 017-0473-9: Moreira N, Sandini TM, Reis-Silva TM, Navas-Suáresz P, Auada AVV, Lebrun I, Flório JC, Bernardi MM, Spinosa HS. Mejias Manzano MLÁ, Giráldez Gallego A, Serrano Jiménez M. Ivermectin reduces motor coordination, serum testosterone, Hepatic veno-occlusive disease induced by Chinese medic- and central neurotransmitter levels but does not affect inal herbs. sexual motivation in male rats. Rev Esp Enferm Dig 2017; online early: Reprod Toxicol 2017; online early: doi: 10.17235/reed.2017.4969/2017: doi: 10.1016/j.reprotox.2017.10.002:

Sakharkar P. Kratom Lead poisoning due to herbal medications. Halpenny GM. Indian J Clin Biochem 2017; 32: 500-1. Mitragyna speciosa: balancing potential medical benefits and abuse. Seo HW, Suh JH, So S-H, Kyung J-S, Kim Y-S, Han C-K. ACS Med Chem Lett 2017; 8: 897-9. Subacute oral toxicity and bacterial mutagenicity study of Korean Red Ginseng oil. J Ginseng Res 2017; 41: 595-601. Lithium Shanks G, Mishra V, Nikolova S.

Endocrine abnormalities in lithium toxicity. Zheng H, Wang Z, Liu W, Jin H, Zhang J. Clin Med 2017; 17: 434-6. Toxicokinetics of strychnine and brucine after the oral administration of Biqi capsule to rats by RRLC-MS/MS. Biomed Chromatogr 2017; online early: Loperamide doi: 10.1002/bmc.4117: Beck R, Atherton DS, Kloda S, Dye DW, Robinson CA. Quantification of loperamide by gas chromatography mass spectrometry. Heroin (diacetylmorphine) J Anal Toxicol 2017; online early: doi: 10.1093/jat/bkx069: Cancelliere A, Blohm E, Neavyn M. A dangerous chase: severe neurocognitive impairment and Salama A, Levin Y, Jha P, Alweis R. death following smoked heroin. Ventricular fibrillation due to overdose of loperamide, the Clin Toxicol 2017; online early: "poor man's methadone". doi: 10.1080/15563650.2017.1392559: J Community Hosp Intern Med Perspect 2017; 7: 222-6.

Griswold MK, Chai PR, Krotulski AJ, Friscia M, Chapman LSD BP, Varma N, Boyer EW, Logan BK, Babu KM. Schmidt A, Müller F, Lenz C, Dolder PC, Schmid Y, Zanchi A novel oral fluid assay (LC-QTOF-MS) for the detection of D, Lang UE, Liechti ME, Borgwardt S. fentanyl and clandestine opioids in oral fluid after reported Acute LSD effects on response inhibition neural networks. heroin overdose. Psychol Med 2017; online early: J Med Toxicol 2017; online early: doi: 10.1007/s13181- doi: 10.1017/S0033291717002914: 017-0632-6:

Heidebrecht F, MacLeod MB, Dawkins L. Metformin Liu S, Xu L, Ma J, Huang R, Lin T, Li Z, Liang H, Li S, Li R, Predictors of heroin abstinence in opiate substitution therapy Zhang L, Tao Y, Li Z, Chen Y, Ye Z, Zhang B, Wang W, Xiao in heroin-only users and dual users of heroin and crack. H, Liang X, Shi W. Addict Behav 2017; 77: 210-6. High-volume continuous venovenous hemodiafiltration plus

resin hemoperfusion improve severe metformin-associated Hypoglycaemic drugs toxicity. Bundhun PK, Janoo G, Teeluck AR, Huang F. J Diabetes Investig 2017; online early:

35

doi: 10.1111/jdi.12757: Tob Res 2017; online early: doi: 10.1093/ntr/ntx162: Monoclonal antibodies Bhatti MT, Salama AKS. Morley S, Slaughter J, Smith PR. Neuro-ophthalmic side effects of molecularly targeted Death from ingestion of e-liquid. cancer drugs. J Emerg Med 2017; online early: Eye (Lond) 2017; online early: doi: 10.1038/eye.2017.222: doi: 10.1016/j.jemermed.2017.06.029:

Wells QS, Freiberg MS, Greevy RA, Jr., Tyndale RF, Kundu Masters JC, Nickens DJ, Xuan D, Shazer RL, Amantea M. S, Duncan MS, King S, Scoville E, Beaulieu D, Gatskie V, Clinical toxicity of antibody drug conjugates: a meta- Tindle HA. analysis of payloads. Nicotine metabolism-informed care for smoking cessation: Invest New Drugs 2017; online early: doi: 10.1007/s10637- a pilot precision RCT. 017-0520-6: Nicotine Tob Res 2017; online early:

doi: 10.1093/ntr/ntx235: Nicotine Beauval N, Antherieu S, Soyez M, Gengler N, Grova N, Novel psychoactive substances Howsam M, Hardy EM, Fischer M, Appenzeller BMR, Blundell MS, Dargan PI, Wood DM. Goossens JF, Allorge D, Garçon G, Lo-Guidice J-M, Garat A. A Cloud on the Horizon A survey into the use of Chemical evaluation of electronic cigarettes: multicomponent – electronic vaping devices for recreational drug and new analysis of liquid refills and their corresponding aerosols. psychoactive substance (NPS) administration. J Anal Toxicol 2017; 41: 670-8. QJM 2017; online early: doi: 10.1093/qjmed/hcx178:

Bengalli R, Ferri E, Labra M, Mantecca P. Lung toxicity of condensed aerosol from E-CIG liquids: influence of the flavor and the in vitro model used. Hondebrink L, Nugteren-van Lonkhuyzen JJ, Rietjens SJ, Int J Environ Res Public Health 2017; 14: 1254. Brunt TM, Venhuis B, Soerdjbalie-Maikoe V, Smink BE, van Riel AJHP, de Vries I. Chi L, Mahbub R, Gao B, Bian X, Tu P, Ru H, Lu K. Fatalities, cerebral hemorrhage, and severe cardiovascular Nicotine alters the gut microbiome and metabolites of gut- toxicity after exposure to the new psychoactive substance brain interactions in a sex-specific manner. 4-fluoroamphetamine: a prospective cohort study. Chem Res Toxicol 2017; online early: Ann Emerg Med 2017; online early: doi: 10.1021/acs.chemrestox.7b00162: doi: 10.1016/j.annemergmed.2017.07.482:

Clapp PW, Jaspers I. Synthetic cannabinoids Electronic cigarettes: their constituents and potential links Armenian P, Darracq M, Gevorkyan J, Clark S, Kaye B, to asthma. Brandehoff NP. Curr Allergy Asthma Rep 2017; 17: 79. Intoxication from the novel synthetic cannabinoids AB- PINACA and ADB-PINACA: A case series and review of the Faulkner P, Petersen N, Ghahremani DG, Cox CM, Tyndale literature. RF, Hellemann GS, London ED. Neuropharmacology 2017; online early: Sex differences in tobacco withdrawal and responses to doi: 10.1016/j.neuropharm.2017.10.017: smoking reduced-nicotine cigarettes in young smokers. Psychopharmacology 2017; online early: Freund SA, Banning AS. doi: 10.1007/s00213-017-4755-x: Synthetic cannabinoids: a review of the clinical implications of a new drug of choice. Fowler CD, Gipson CD, Kleykamp BA, Rupprecht LE, Harrell J Am Acad Physician Assist 2017; 30: 1-4. PT, Rees VW, Gould TJ, Oliver J, Bagdas D, Damaj MI, Schmidt HD, Duncan A, De Biasi M, Basic Science Network Funada M, Takebayashi-Ohsawa M. (BSN) of the Society for Research on Nicotine and Tobacco Synthetic cannabinoid AM2201 induces seizures: (SRNT). involvement of cannabinoid CB1 receptors and glutamatergic Basic science and public policy: informed regulation for transmission. nicotine and tobacco products. Toxicol Appl Pharmacol 2017; online early: Nicotine Tob Res 2017; online early: doi: 10.1016/j.taap.2017.10.007: doi: 10.1093/ntr/ntx175: Glicksberg L, Kerrigan S. Hamouda AK, Jackson A, Bagdas D, Damaj MI. Stability of synthetic in blood. Reversal of nicotine withdrawal signs through positive J Anal Toxicol 2017; online early: doi: 10.1093/jat/bkx071: allosteric modulation of 42 nicotinic receptors in male mice. Göl E, Çok I. Nicotine Tob Res 2017; online early: Assessment of types of synthetic cannabinoids in narcotic doi: 10.1093/ntr/ntx183: cases assessed by the Council of Forensic Medicine between 2011–2015, Ankara, Turkey. Ji M, Zhang Y, Li N, Wang C, Xia R, Zhang Z, Wang S-L. Forensic Sci Int 2017; 280: 124-9. Nicotine component of cigarette smoke extract (CSE) decreases the cytotoxicity of CSE in BEAS-2B cells stably Haden M, Wood DM, Dargan PI. expressing human 2A13. The impact of the Psychoactive Substances Act 2016 on Int J Environ Res Public Health 2017; 14: 1221. the online availability of MDMB-CHMICA. QJM 2017; online early: doi: 10.1093/qjmed/hcx045: Kosmider L, Kimber CF, Kurek J, Corcoran O, Dawkins LE. Compensatory puffing with lower nicotine concentration e- Hermanns-Clausen M, Müller D, Kithinji J, Angerer V, liquids increases carbonyl exposure in e-cigarette aerosols. Franz F, Eyer F, Neurath H, Liebetrau G, Auwärter V.

36

Acute side effects after consumption of the new synthetic Pain management and the opioid epidemic: balancing cannabinoids AB-CHMINACA and MDMB-CHMICA. societal and individual benefits and risks of prescription Clin Toxicol 2017; online early: opioid use. doi: 10.1080/15563650.2017.1393082: 2017; Washington, DC. National Academic Press.

Hill SL, Dunn M, Cano C, Harnor SJ, Hardcastle IR, Chihuri S, Li G. Grundlingh J, Dargan PI, Wood DM, Tucker S, Bartram T, Use of prescription opioids and motor vehicle crashes: a Thomas SHL. meta analysis. Human toxicity caused by indole and indazole carboxylate Accid Anal Prev 2017; 109: 123-31. synthetic cannabinoid receptor agonists: from horizon scanning to notification. Clark DJ, Schumacher MA. Clin Chem 2017; online early: America's opioid epidemic: supply and demand consid- doi: 10.1373/clinchem.2017.275867: erations. Anesth Analg 2017; 125: 1667-74. Yeter O. Identification of the synthetic cannabinoid 1-(4- Coffin PO, Santos G-M, Matheson T, Behar E, Rowe C, cyanobutyl)-N-(2-phenylpropan-2-yl)-1H-indazole-3- Rubin T, Silvis J, Vittinghoff E. carboxamide (CUMYL-4CN-BINACA) in plant material and Behavioral intervention to reduce opioid overdose among quantification in post-mortem blood samples. high-risk persons with opioid use disorder: a pilot J Anal Toxicol 2017; online early: doi: 10.1093/jat/bkx061: randomized controlled trial. PLoS ONE 2017; 12: e0183354.

Synthetic cathinones Collier R. Fujita Y, Mita T, Usui K, Kamijo Y, Kikuchi S, Onodera M, 16 hospitalizations daily for opioid poisoning. Fujino Y, Inoue Y. Can Med Assoc J 2017; 189: E1248. Toxicokinetics of the synthetic cathinone -pyrrolidino- hexanophenone. Cooperman NA, Lu S-E, Richter KP, Bernstein SL, Williams JM. J Anal Toxicol 2017; online early: doi: 10.1093/jat/bkx080: Pilot Study of a tailored smoking cessation intervention for individuals in treatment for opioid dependence. Karila L, Lafaye G, Scocard A, Cottencin O, Benyamina A. Nicotine Tob Res 2017; online early: MDPV and -PVP use in humans: the twisted sisters. doi: 10.1093/ntr/ntx189: Neuropharmacology 2017; online early: doi: 10.1016/j.neuropharm.2017.10.007: Deyo RA, Hallvik SE, Hildebran C, Marino M, Springer R, Irvine JM, O'Kane N, Van OJ, Wright DA, Leichtling G, Silva B, Fernandes C, Guedes de Pinho P, Remião F. Millet LM, Carson J, Wakeland W, McCarty D. Chiral resolution and enantioselectivity of synthetic Association of prescription drug monitoring program use cathinones: a brief review. with opioid prescribing and health outcomes: a comparison J Anal Toxicol 2017; online early: doi: 10.1093/jat/bkx074: of program users and non-users. J Pain 2017; online early: doi: 10.1016/j.jpain.2017.10.001: Williams M, Martin J, Galettis P. A validated method for the detection of 32 bath salts in Dowell D, Arias E, Kochanek K, Anderson R, Guy GP, Jr., oral fluid. Losby JL, Baldwin G. J Anal Toxicol 2017; 41: 659-69. Contribution of opioid-involved poisoning to the change in life expectancy in the United States, 2000-2015. Synthetic opioids JAMA 2017; 318: 1065-7.

Allibe N, Richeval C, Phanithavong M, Faure A, Allorge D, Downey E, Pan W, Harrison J, Poza-Juncal E, Tanabe P. Paysant F, Stanke-Labesque F, Eysseric-Guerin H, Gaulier Implementation of a Schedule II patient agreement for J-M. opioids and stimulants in an adult primary care practice. Fatality involving ocfentanil documented by identification J Family Med Prim Care 2017; 6: 52-7. of metabolites.

Drug Test Anal 2017; online early: doi: 10.1002/dta.2326: Dudley LS, Konomos D, Robbins V, Qiu L, Bauter R,

Merlin MA. Armenian P, Vo KT, Barr-Walker J, Lynch KL. Opioid crisis at the Jersey Shore—special report. Fentanyl, fentanyl analogs and novel synthetic opioids: a J Public Health (UK) 2017; online early: comprehensive review. doi: 10.1093/pubmed/fdx106: Neuropharmacology 2017; online early: doi: 10.1016/j.neuropharm.2017.10.016: Geissert P, Hallvik S, Van Otterloo J, O'Kane N, Alley L, Carson J, Leichtling G, Hildebran C, III, Wakeland W, NSAIDs Deyo RA. Ketoprofen High-risk prescribing and opioid overdose: prospects for prescription drug monitoring program based proactive alerts. Hirose S, Matsuura K, Kato-Hayashi H, Suzuki A, Ohata K, Pain 2017; online early: Kobayashi R, Ibuka T, Araki H, Shimizu M, Itoh Y. doi: 10.1097/j.pain.0000000000001078: Gastrointestinal bleeding associated with chronic excessive use overdosing with topical ketoprofen patch in elderly Griswold MK, Chai PR, Krotulski AJ, Friscia M, Chapman patient. BP, Varma N, Boyer EW, Logan BK, Babu KM. Scand J Gastroenterol 2017; online early: A novel oral fluid assay (LC-QTOF-MS) for the detection of doi: 10.1080/00365521.2017.1390602: fentanyl and clandestine opioids in oral fluid after reported

heroin overdose. Opioids J Med Toxicol 2017; online early: doi: 10.1007/s13181- Bonnie RJ, Ford MA, Phillips JK. 017-0632-6:

37

National trends and outcomes of cardiac arrest in opioid Gulec N, Lahey J, Suozzi JC, Sholl M, MacLean CD, overdose. Wolfson DL. Resuscitation 2017; 121: 84-9. Basic and advanced EMS providers are equally effective in naloxone administration for opioid overdose in Northern Schiff DM, Drainoni M-L, Weinstein ZM, Chan L, Bair- New England. Merritt M, Rosenbloom D. Prehosp Emerg Care 2017; online early: A police-led addiction treatment referral program in doi: 10.1080/10903127.2017.1371262: Gloucester, MA: Implementation and participants' expe- riences. Hah JM, Bateman BT, Ratliff J, Curtin C, Sun E. J Subst Abuse Treat 2017; 82: 41-7. Chronic opioid use after surgery: implications for perioperative management in the face of the opioid epidemic. Sinha S, Jensen M, Mullin S, Elkin PL. Anesth Analg 2017; 125: 1733-40. Safe opioid prescription: a SMART on FHIR approach to clinical decision support. Hartung DM, Kim H, Ahmed SM, Middleton L, Keast S, Online J Public Health Inform 2017; 9: e193. Deyo RA, Zhang K, McConnell KJ. Effect of a high dosage opioid prior authorization policy on Skolnick P. prescription opioid use, misuse, and overdose outcomes. The opioid epidemic: crisis and solutions. Subst Abus 2017; online early: Annu Rev Pharmacol Toxicol 2017; online early: doi: doi: 10.1080/08897077.2017.1389798: 10.1146/annurev-pharmtox-010617-052534:

Ho J, DeBeck K, Milloy M-J, Dong H, Wood E, Kerr T, Soelberg CD, Brown RE, Jr., Du VD, Meyer JE, Hayashi K. Ramachandran BK. Increasing availability of illicit and prescription opioids The US opioid crisis: current federal and state legal issues. among people who inject drugs in a Canadian setting, Anesth Analg 2017; 125: 1675-81.

2010–2014. Am J Drug Alcohol Abuse 2017; online early: Tanum L, Solli KK, Latif ZE, Benth JŠ, Opheim A, Sharma- doi: 10.1080/00952990.2017.1376678: Haase K, Krajci P, Kunøe N. The effectiveness of injectable extended-release naltrexone Juurlink DN. vs daily buprenorphine-naloxone for opioid dependence: a randomized clinical noninferiority trial. Rethinking "doing well" on chronic opioid therapy. JAMA Psychiatry 2017; online early: Can Med Assoc J 2017; 189: E1222-E1223. doi: 10.1001/jamapsychiatry.2017.3206:

Knipper E, Banta-Green CJ, Jimenez N. Tedesco D, Asch SM, Curtin C, Hah J, McDonald KM, Opioid use disorder and misuse: a review of the epidemiology Fantini MP, Hernandez-Boussard T. and medical implications for pediatric anesthesiologists. Opioid abuse and poisoning: trends in inpatient and Paediatr Anaesth 2017; 27: 1070-6. emergency department discharges.

Health Aff 2017; 36: 1748-53. Lagisetty P, Klasa K, Bush C, Heisler M, Chopra V, Bohnert A.

Primary care models for treating opioid use disorders: Tolia VN, Murthy K, Bennett MM, Miller ES, Benjamin DK, What actually works? A systematic review. Smith PB, Clark RH. PLoS ONE 2017; 12: e0186315. Antenatal methadone vs buprenorphine exposure and length of hospital stay in infants admitted to the intensive Larance B, Degenhardt L, Peacock A, Gisev N, Mattick R, care unit with neonatal abstinence syndrome. Colledge S, Campbell G. J Perinatol 2017; online early: doi: 10.1038/jp.2017.157: Pharmaceutical opioid use and harm in Australia: the need for proactive and preventative responses. Volkow N, Benveniste H, McLellan AT. Drug Alcohol Rev 2017; online early: Use and misuse of opioids in chronic pain. doi: 10.1111/dar.12617: Annu Rev Med 2017; online early: doi: 10.1146/annurev- med-011817-044739: Morlion BJ, Mueller-Lissner SA, Vellucci R, Leppert W, Coffin BC, Dickerson SL, O'Brien T. Vyas MB, LeBaron VT, Gilson AM. Oral prolonged-release oxycodone/naloxone for managing The use of cannabis in response to the opioid crisis: a pain and opioid-induced constipation: a review of the review of the literature. evidence. Nurs Outlook 2017; online early: Pain Pract 2017; online early: doi: 10.1111/papr.12646: doi: 10.1016/j.outlook.2017.08.012:

Muñoz-Muñoz AC, Pekol T, Schubring D, Johnson C, Webster LR. Andrade L. Risk factors for opioid-use disorder and overdose. Identification of novel opioid interferences using high- Anesth Analg 2017; 125: 1741-8. resolution mass spectrometry. J Anal Toxicol 2017; online early: doi: 10.1093/jat/bkx065: Wen LS, Warren KE. Combatting the opioid epidemic: Baltimore's experience Powers D, Erickson S, Swortwood MJ. and lessons learned. Quantification of morphine, codeine, and thebaine in J Public Health (UK) 2017; online early: home-brewed poppy seed tea by LC-MS/MS. doi: 10.1093/pubmed/fdx093: J Forensic Sci 2017; online early: doi: 10.1111/1556- 4029.13664: Zhou K, Jia P, Bhargava S, Zhang Y, Reza T, Peng YB, Wang GG. Sakhuja A, Sztajnkrycer M, Vallabhajosyula S, Opioid tapering in patients with prescription opioid use Cheungpasitporn W, Patch R, III, Jentzer J. disorder: a retrospective study.

38

Scand J Pain 2017; 17: 167-73. MMWR Morb Mortal Wkly Rep 2017; 66: 1119-20.

Carfentanil Tramadol Papsun D, Isenschmid D, Logan BK. Cornthwaite HM, Labine L, Watterson JH. Observed carfentanil concentrations in 355 blood Semi-quantitative analysis of tramadol, dextromethorphan specimens from forensic investigations. and metabolites in decomposed skeletal tissues by ultra J Anal Toxicol 2017; online early: doi: 10.1093/jat/bkx068: performance liquid chromatography quadrupole time of flight mass spectrometry (UPLC-qTOF-MS). Fentanyl Drug Test Anal 2017; online early: doi: 10.1002/dta.2327:

Barry CL. Fentanyl and the evolving opioid epidemic: what strategies U-47700 should policy makers consider? Rohrig TP, Miller SA, Baird TR. Psychiatr Serv 2017; online early: U-47700: a not so new opioid. doi: 10.1176/appi.ps.201700235: J Anal Toxicol 2017; online early: doi: 10.1093/jat/bkx081:

Butler DC, Shanks K, Behonick GS, Smith D, Presnell SE, Paracetamol (acetaminophen) Tormos LM. Cai Y, Sun W, Zhang X, Lin Y, Chen H, Li H. Three cases of fatal acrylfentanyl toxicity in the United Osthole prevents acetaminophen-induced liver injury in mice. States and a review of literature. Acta Pharmacol Sin 2017; online early: J Anal Toxicol 2017; online early: doi: 10.1093/jat/bkx083: doi: 10.1038/aps.2017.129:

Socias ME, Wood E. Dokumacioglu E, Iskender H, Aktas MS, Hanedan B, Epidemic of deaths from fentanyl overdose. Dokumacioglu A, Sen TM, Musmul A. Br Med J 2017; 358: j4355. The effect of sulforaphane on oxidative stress and inflam- mation in rats with toxic hepatitis induced by ac- Vengerovich NG, Yudin MA, Bykov VN, Nikiforov AS, etaminophene. Aleshina OI, Kuz'min AA, Ustinova TM, Gadzikovskii SV. Bratisl Lek Listy 2017; 118: 453-9. Analysis of the efficiency of microencapsulated sustained- release form of naloxone on the experimental model of Edison L, Erickson A, Smith S, Lopez G, Hon S, King A, fentanyl poisoning. Nydam N, O'Neal JP, Drenzek C. Bull Exp Biol Med 2017; online early: doi: 10.1007/s10517- Notes from the field: Counterfeit percocet-related 017-3892-x: overdose cluster – Georgia, June 2017. MMWR Morb Mortal Wkly Rep 2017; 66: 1119-20. Methadone Bogen DL, Hanusa BH, Perel JM, Sherman F, Mendelson Ramachandran A, Jaeschke H. MA, Wisner KL. Acetaminophen toxicity novel insights into mechanisms Corrected QT interval and methadone dose and concen- and future perspectives. trations in pregnant and postpartum women. Gene Expr 2017; online early: J Clin Psychiatry 2017; online early: doi: 10.3727/105221617X15084371374138: doi: 10.4088/JCP.16m11318: Rivera P, Pastor A, Arrabal S, Decara J, Vargas A, Sánchez-

Marín L, Pavón FJ, Serrano A, Bautista D, Boronat A, de la MT-45 Torre R, Baixeras E, Lucena MI, De Fonseca FR, Suárez J. Montesano C, Vannutelli G, Fanti F, Vincenti F, Gregori A, Acetaminophen-induced liver injury alters the acyl Rita Togna A, Canazza I, Marti M, Sergi M. ethanolamine-based anti-inflammatory signaling system in Identification of MT-45 metabolites: in silico prediction, in liver. vitro incubation with rat hepatocytes and in vivo Front Pharmacol 2017; 8: 705. confirmation. J Anal Toxicol 2017; 41: 688-97. Phencyclidine

Tran T-V, Shin E-J, Dang D-K, Ko SK, Jeong JH, Nah S-Y, Opium Jang C-G, Lee YJ, Toriumi K, Nabeshima T, Kim HC. Hayatbakhsh MM, Oghabian Z, Conlon E, Nakhaee S, Ginsenoside Re protects against phencyclidine-induced Amirabadizadeh AR, Zahedi MJ, Darvish Moghadam S, behavioral changes and mitochondrial dysfunction via Ahmadi B, Soroush S, Aaseth J, Mehrpour O. interactive modulation of glutathione peroxidase-1 and Lead poisoning among opium users in Iran: an emerging NADPH oxidase in the dorsolateral cortex of mice. health hazard. Food Chem Toxicol 2017; online early: Subst Abuse Treat Prev Policy 2017; 12: 43. doi: 10.1016/j.fct.2017.10.019:

Ortho-fluorofentanyl Potassium Helland A, Brede WR, Michelsen LS, Gundersen POM, Schaeffer C, Poincet S, Teruzzi B, Galas T, Vandroux D. Aarset H, Skjølås JE, Slørdal L. A massive overdose of potassium pills. Two hospitalizations and one death after exposure to Anaesth Crit Care Pain Med 2017; online early: ortho-fluorofentanyl. doi: 10.1016/j.accpm.2017.10.001: J Anal Toxicol 2017; 41: 708-9. Proteasome inhibitors Oxycodone Fradley MG, Groarke JD, Laubach J, Alsina M, Lenihan DJ, Edison L, Erickson A, Smith S, Lopez G, Hon S, King A, Cornell RF, Maglio M, Shain KH, Richardson PG, Moslehi J. Nydam N, O'Neal JP, Drenzek C. Recurrent cardiotoxicity potentiated by the interaction of Notes from the field: Counterfeit percocet-related overdose proteasome inhibitor and immunomodulatory therapy for cluster – Georgia, June 2017. the treatment of multiple myeloma.

39

Br J Haematol 2017; online early: doi: 10.1111/bjh.14970: Patterns of substance use and mortality risk in a cohort of 'hard-to-reach' polysubstance users. Prothipendyl Addiction 2017; online early: doi: 10.1111/add.14053: Krämer M, Heese P, Banger M, Madea B, Hess C. Range of therapeutic prothipendyl and prothipendyl Lackovic Z. sulfoxide concentrations in clinical blood samples. "Bunanje": XX century abuse of Atropa belladonna Drug Test Anal 2017; online early: doi: 10.1002/dta.2319: halucinogenic berries in continental Croatia. Psychiatr Danub 2017; 29: 379-82.

Rosiglitazone Mack KA, Jones CM, Ballesteros MF. Sagir D, Eren B, Yilmaz BD, Eren Z, Keles ON, Gökçe AB. Illicit drug use, illicit drug use disorders, and drug overdose Effects of prenatal PPAR-gamma agonist rosiglitazone deaths in metropolitan and nonmetropolitan areas – United exposure on rat hippocampus development in a time- States. dependent manner: A stereological and histopathological MMWR Surveill Summ 2017; 66: 1-12. study. Hum Exp Toxicol 2017; online early: Meier UCJ, Briellmann T, Scheurer E, Dussy F. doi: 10.1177/0960327117730883: Sample preparation method for the combined extraction of ethyl glucuronide and drugs of abuse in hair. Sedatives Drug Test Anal 2017; online early: doi: 10.1002/dta.2314: Zolpidem Myers PL. Feng X, Xiang P, Chen H, Shen M. Humanizing folk devils using ethnography. LC-MS-MS with post-column reagent addition for the J Ethn Subst Abuse 2017; online early: determination of zolpidem and its metabolite zolpidem doi: 10.1080/15332640.2017.1362725: phenyl-4-carboxylic acid in oral fluid after a single dose.

J Anal Toxicol 2017; online early: doi: 10.1093/jat/bkx062: Nambiar D, Spelman T, Stoové M, Dietze P.

Are people who inject drugs frequent users of emergency SSRIs and SNRIs department services? A cohort study (2008–2013). Fluoxetine Subst Use Misuse 2017; online early: da Silva ACC, Raasch JR, Vargas TG, Peteffi GP, Hahn RZ, doi: 10.1080/10826084.2017.1341921: Antunes MV, Perassolo MS, Linden R. Simultaneous determination of fluoxetine and Ordean A, Wong S, Graves L. norfluoxetine in dried blood spots using high-performance No. 349-Substance use in pregnancy. liquid chromatography-tandem mass spectrometry. J Obstet Gynaecol Can 2017; 39: 922-37.e2. Clin Biochem 2017; online early: doi: 10.1016/j.clinbiochem.2017.10.002: Riley AL, Hempel BJ, Clasen MM. Sex as a biological variable: drug use and abuse. Physiol Behav 2017; online early: Statins doi: 10.1016/j.physbeh.2017.10.005: Bellosta S, Corsini A. Statin drug interactions and related adverse reactions: an Roncero C, Ros-Cucurull E, Palma-Álvarez RF, Abad AC, update. Fadeuilhe C, Casas M, Grau-López L. Expert Opin Drug Saf 2017; online early: Inhaled loxapine for agitation in intoxicated patients: a doi: 10.1080/14740338.2018.1394455: case series. Clin Neuropharmacol 2017; online early: Substance abuse doi: 10.1097/WNF.0000000000000252: Boland JK, Rosenfeld B. The role of controlled substance use in diversion outcomes Sato T, Nishioka H, Tsuboi K, Katagi M, Miki A, Saito T, among mentally ill offenders: a pilot study. Abe S, Nomura M, Kitagawa M, Tsuchihashi H, Suzuki K. Int J Offender Ther Comp Criminol 2017; online early: Detection of butane gas inhalation at 16 days after doi: 10.1177/0306624X17735093: hypoxic encephalopathy: a case report. Leg Med 2017; 29: 34-7. Fluharty ME, Heron J, Munafò MR. Longitudinal associations of social cognition and substance Sellers EM, Romach MK. use in childhood and early adolescence: findings from the Categorization of abuse potential-related adverse events. Avon Longitudinal Study of Parents and Children. Clin Pharmacol Drug Dev 2017; online early: Eur Child Adolesc Psychiatry 2017; online early: doi: 10.1002/cpdd.394: doi: 10.1007/s00787-017-1068-x: Ullah S, Sandqvist S, Beck O. Gaddis A, Kennedy MC, Nosova E, Milloy M-J, Hayashi K, A liquid chromatography and tandem mass spectrometry Wood E, Kerr T. method to determine 28 non-volatile drugs of abuse in Use of on-site detoxification services co-located with a exhaled breath. supervised injection facility. J Pharm Biomed Anal 2017; 148: 251-8. J Subst Abuse Treat 2017; 82: 1-6. Volkow N, Benveniste H, McLellan AT. Ghaderi A, Motmaen M, Abdi I, Rasouli-Azad M. Use and misuse of opioids in chronic pain. Gender differences in substance use patterns and disorders Annu Rev Med 2017; online early: doi: 10.1146/annurev- among an Iranian patient sample receiving methadone med-011817-044739: maintenance treatment. Electron Physician 2017; 9: 5354-62. Weis S, Büttner A. Neurotoxicology and drug-related disorders. Gjersing L, Bretteville-Jensen AL. Handb Clin Neurol 2017; 145: 181-92.

40

Vitamins Dai Y, Ren D, Bassig BA, Vermeulen R, Hu W, Niu Y, Duan H, Ye M, Meng T, Xu J, Bin P, Shen M, Yang J, Fu W, Calciferol Meliefste K, Silverman D, Rothman N, Lan Q, Zheng Y. Bilbao NA. Occupational exposure to diesel engine exhaust and Vitamin D toxicity in young breastfed infants: report of 2 serum cytokine levels. cases. Environ Mol Mutagen 2017; online early: Glob Pediatr Health 2017; 4: doi: 10.1002/em.22142: doi: 10.1177/2333794X17731695. Lawal AO. Van K, Lai FYX, Ling J, Wood C. Diesel exhaust particles and the induction of macrophage The latest scoop: a rare case of vitamin D toxicity. activation and dysfunction. Am J Med 2017; online early: Inflammation 2017; online early: doi: 10.1007/s10753-017- doi: 10.1016/j.amjmed.2017.09.043: 0682-6:

CHEMICAL INCIDENTS AND PM10 Williams LJ, Chen L, Zosky GR. POLLUTION The respiratory health effects of geogenic (earth derived) Air pollution PM10. Anderson SM, Naidoo RN, Ramkaran P, Phulukdaree A, Inhal Toxicol 2017; 29: 342-55. Muttoo S, Asharam K, Chuturgoon AA. The effect of nitric oxide pollution on oxidative stress in Chemical incidents pregnant women living in Durban, South Africa. Huang M, Mesaros CA, Hackfield LC, Hodge RP, Blair IA, Arch Environ Contam Toxicol 2017; online early: doi: Penning TM. 10.1007/s00244-017-0465-y: Potential metabolic activation of representative alkylated polycyclic aromatic hydrocarbons 1-methylphenanthrene Cournane S, Conway R, Byrne D, O'Riordan D, Coveney S, and 9-ethylphenanthrene associated with the Deepwater Silke B. Horizon oil spill in human hepatoma (HepG2) cells. High risk subgroups sensitive to air pollution levels Chem Res Toxicol 2017; online early: following an emergency medical admission. doi: 10.1021/acs.chemrestox.7b00232: Toxics 2017; 5: 27. Pasquier M, Dami F, Carron P-N, Yersin B, Pignel R, Hugli O. Ebisu K, Malig B, Hasheminassab S, Sioutas C, Basu R. Mass casualty triage in the case of carbon monoxide Cause-specific stillbirth and exposure to chemical poisoning: lessons learned. constituents and sources of fine particulate matter. Disaster Med Public Health Prep 2017; online early: doi: Environ Res 2018; 160: 358-64. 10.1017/dmp.2017.65:

Hu Y, Wang L-S, Li Y, Li Q, Li C-L, Chen J-M, Weng D, Li H-P. Yorifuji T, Kashima S, Suryadhi MAH, Abudureyimu K. Effects of particulate matter from straw burning on lung Temporal trends of infant and birth outcomes in Minamata fibrosis in mice. after severe methylmercury exposure. Environ Toxicol Pharmacol 2017; 56: 249-58. Environ Pollut 2017; online early: doi: 10.1016/j.envpol.2017.09.060: Lawal AO. Diesel exhaust particles and the induction of macrophage Pollution and hazardous waste activation and dysfunction. Cesaro A, Belgiorno V, Vaccari M, Jandric A, Chung TD, Inflammation 2017; online early: doi: 10.1007/s10753-017- Dias MI, Hursthouse A, Salhofer S. 0682-6: A device-specific prioritization strategy based on the

potential for harm to human health in informal WEEE Ma J, Simonich S, Tao S. recycling. New discoveries to old problems: a virtual issue on air Environ Sci Pollut Res 2017; online early: pollution in rapidly industrializing countries. doi: 10.1007/s11356-017-0390-7: Environ Sci Technol 2017; 51: 11497-501.

Salvo A, La Torre GL, Mangano V, Casale KE, Bartolomeo Martens DS, Cox B, Janssen BG, Clemente DBP, Gasparrini A, G, Santini A, Granata T, Dugo G. Vanpoucke C, Lefebvre W, Roels HA, Plusquin M, Nawrot TS. Toxic inorganic pollutants in foods from agricultural producing Prenatal air pollution and newborns' predisposition to areas of Southern Italy: Level and risk assessment. accelerated biological aging. Ecotoxicol Environ Saf 2017; 148: 114-24. JAMA Pediatr 2017; online early: doi: 10.1001/jamapediatrics.2017.3024: CHEMICALS Exhaust fumes General Bassig BA, Dai Y, Vermeulen R, Ren D, Hu W, Duan H, Niu Chary A, Hennen J, Klein SG, Serchi T, Gutleb AC, Y, Xu J, Shiels MS, Kemp TJ, Pinto LA, Fu W, Meliefste K, Blömeke B. Zhou B, Yang J, Ye M, Jia X, Meng T, Wong JYY, Bin P, Respiratory sensitization: toxicological point of view on the Hosgood HD, III, Hildesheim A, Silverman DT, Rothman N, available assays. Zheng Y, Lan Q. Arch Toxicol 2017; online early: doi: 10.1007/s00204-017- Occupational exposure to diesel engine exhaust and 2088-5: alterations in immune/inflammatory markers: a cross- sectional molecular epidemiology study in China. Chebekoue SF, Krishnan K. Carcinogenesis 2017; online early: Derivation of occupational thresholds of toxicological concern doi: 10.1093/carcin/bgx081: for systemically acting noncarcinogenic organic chemicals.

41

Toxicol Sci 2017; 160: 47-56. 1,3-butadiene Chappell GA, Israel JW, Simon JM, Pott S, Safi A, Eklund Chokhandre P, Singh S, Kashyap GC. K, Sexton KG, Bodnar W, Lieb JD, Crawford GE, Rusyn I, Prevalence, predictors and economic burden of morbidities Furey TS. among waste-pickers of Mumbai, India: a cross-sectional Variation in DNA-damage responses to an inhalational study. carcinogen (1,3-Butadiene) in relation to strain-specific J Occup Med Toxicol 2017; 12: 30. differences in chromatin accessibility and gene transcription profiles in C57BL/6J and CAST/EiJ mice. Cowell WJ, Wright RJ. Environ Health Perspect 2017; 125: 107006. Sex-specific effects of combined exposure to chemical and non-chemical stressors on neuroendocrine development: a Abrin review of eecent findings and putative mechanisms. Tam CC, Cheng LW, He X, Merrill P, Hodge D, Stanker LH. Curr Environ Health Rep 2017; online early: A monoclonal-monoclonal antibody based capture ELISA doi: 10.1007/s40572-017-0165-9: for abrin. Toxins (Basel) 2017; 9: 328. Desbiolles A, Roudier C, Goria S, Stempfelet M, Kairo C, Quintin C, Bidondo M-L, Monnereau A, Vacquier B. Tam CC, Henderson TD, Stanker LH, He X, Cheng LW. Cancer incidence in adults living in the vicinity of nuclear Abrin toxicity and bioavailability after temperature and pH power plants in France, based on data from the French treatment. Network of Cancer Registries. Toxins (Basel) 2017; 9: 320. Int J Cancer 2017; online early: doi: 10.1002/ijc.31116: Acrylamide DeVito SC. Kim H, Lee SG, Rhie J. The need for, and the role of the toxicological chemist in Dermal and neural toxicity caused by acrylamide exposure the design of safer chemicals. in two Korean grouting workers: a case report. Toxicol Sci 2017; online early: doi: 10.1093/toxsci/kfx197: Ann Occup Environ Med 2017; 29: 50.

Eiffert S, Etienne S, Hirsch A, Langley R. Aflatoxins North Carolina Toxic Substance Incidents Program 2010– 2015: identifying areas for injury prevention efforts. Mohajeri M, Behnam B, Cicero FG, Sahebkar A. Toxics 2017; 5: 16. Protective effects of curcumin against aflatoxicosis: a comprehensive review. Etzel RA. J Cell Physiol 2017; online early: doi: 10.1002/jcp.26212:

Foreword-Pediatric environmental health: using data on toxic chemical emissions in practice. Alcohol (ethanol) Curr Probl Pediatr Adolesc Health Care 2017; online early: Abarikwu SO, Njoku RC, Lawrence CJ, Charles IA, doi: 10.1016/j.cppeds.2017.09.003: Ikewuchi JC. Rutin ameliorates oxidative stress and preserves hepatic Koehrn K, Hospital J, Woolf A, Lowry J. and renal functions following exposure to cadmium and Pediatric environmental health: using data on toxic ethanol. chemical emissions in practice. Pharm Biol 2017; 55: 2161-9. Curr Probl Pediatr Adolesc Health Care 2017; online early: doi: 10.1016/j.cppeds.2017.09.002: Andreassen TN, Havnen H, Spigset O, Falch BMH, Skråstad RB. Lamb J, Galea KS, Miller BG, Hesse S, van Tongeren M. High throughput UPLC®-MSMS method for the analysis of Between-user reliability of tier 1 exposure assessment tools phosphatidylethanol (PEth) 16:0/18:1, a specific biomarker used under REACH. for alcohol consumption, in whole blood. Ann Work Expo Health 2017; 61: 939-53. J Anal Toxicol 2017; online early: doi: 10.1093/jat/bkx075:

Campbell AE, Chambers CD, Allen CPG, Hedge C, Sumner P. Snodin DJ. Impairment of manual but not saccadic response inhibition The cancer threshold of toxicological concern (TTC) in following acute alcohol intoxication. relation to foodstuffs and pharmaceuticals: a potentially Drug Alcohol Depend 2017; online early: doi: useful concept compromised by a dubious derivation. 10.1016/j.drugalcdep.2017.08.022: Hum Exp Toxicol 2017; online early: doi: 10.1177/960327117735571: Contreras A, Morales L, Tebourbi A, Miguens M, Olmo ND, Pérez García C. Trisciuzzi D, Alberga D, Mansouri K, Judson RS, Novellino Age dependent effects of acute alcohol administration in E, Mangiatordi GF, Nicolotti O. the hippocampal phosphoproteome. Predictive structure-based toxicology approaches to assess Chem Res Toxicol 2017; online early: the androgenic potential of chemicals. doi: 10.1021/acs.chemrestox.7b00260: J Chem Inf Model 2017; online early: doi: 10.1021/acs.jcim.7b00420: Dubinkina VB, Tyakht AV, Odintsova VY, Yarygin KS, Kovarsky BA, Pavlenko AV, Ischenko DS, Popenko AS, van Tongeren M, Lamb J, Cherrie JW, MacCalman L, Alexeev DG, Taraskina AY, Nasyrova RF, Krupitsky EM, Basinas I, Hesse S. Shalikiani NV, Bakulin IG, Shcherbakov PL, Skorodumova Validation of lower tier exposure tools used for REACH: LO, Larin AK, Kostryukova ES, Abdulkhakov RA, comparison of tools estimates with available exposure Abdulkhakov SR, Malanin SY, Ismagilova RK, Grigoryeva TV, measurements. Ilina EN, Govorun VM. Ann Work Expo Health 2017; 61: 921-38. Links of gut microbiota composition with alcohol dependence syndrome and alcoholic liver disease.

42

Microbiome 2017; 5: 141. Alcohol 2017; 64: 23-8.

Gaddam M, Velagapudi RK, Abu SE, Kanzy A. Benzene Two gaps too many, three clues too few? Do elevated Lovreglio P, De Palma G, Barbieri A, Andreoli R, Drago I, osmolal and anion gaps with crystalluria always mean Greco L, Gallo E, Diomede L, Scaramuzzo P, Ricossa MC, ethylene glycol poisoning? Fostinelli J, Apostoli P, Soleo L. BMJ Case Rep 2017; doi: 10.1136/bcr-2017-221739: Biological monitoring of exposure to low concentrations of benzene in workers at a metallurgical coke production plant: Kirpich I, McClain C. new insights into S-phenylmercapturic acid and urinary More alcohol, more liver injury: not always true. benzene. Alcohol Alcohol 2017; online early: Biomarkers 2017; online early: doi: 10.1093/alcalc/agx064: doi: 10.1080/1354750X.2017.1387935:

Koneru M, Sahu BD, Mir SM, Ravuri HG, Kuncha M, Mahesh KJ, Kilari EK, Sistla R. Bisphenol A Capsaicin, the pungent principle of peppers, ameliorates Kazemi S, Mousavi Kani SN, Rezazadeh L, Pouramir M, alcohol-induced acute liver injury in mice via modulation of Ghasemi-Kasman M, Moghadamnia AA. matrix metalloproteinases. Low dose administration of Bisphenol A induces liver Can J Physiol Pharmacol 2017; online early: toxicity in adult rats. doi: 10.1139/cjpp-2017-0473: Biochem Biophys Res Commun 2017; online early: doi: 10.1016/j.bbrc.2017.10.074: Larabi IA, Fabresse N, Knapp A, Forcet M, Baud FJ, Grandmaison dlGL, Alvarez JC. Poet T, Hays S. LC-MS/MS method for quantification of baclofen in hair: a Extrapolation of plasma clearance to understand species useful tool to assess compliance in alcohol dependent differences in toxicokinetics of bisphenol A. patients? Xenobiotica 2017; online early: Drug Test Anal 2017; online early: doi: 10.1002/dta.2308: doi: 10.1080/00498254.2017.1379626:

Lee KH. Reddivari L, Veeramachaneni DNR, Walters WA, Lozupone Should alcohol screening be a routine practice in alcohol- C, Palmer J, Hewage MKK, Bhatnagar R, Amir A, Kennett related facial trauma care? A narrative review. MJ, Knight R, Vanamala JKP. Oral Maxillofac Surg 2017; online early: Perinatal bisphenol A exposure induces chronic doi: 10.1007/s10006-017-0662-x: inflammation in rabbit offspring via modulation of gut bacteria and their metabolites. Neufeld M, Rehm J. mSystems 2017; 2: e00093-17. Effectiveness of policy changes to reduce harm from unrecorded alcohol in Russia between 2005 and now. Renaud L, da Silveira WA, Hazard ES, Simpson J, Falcinelli Int J Drug Policy 2018; 51: 1-9. S, Chung D, Carnevali O, Hardiman G. The plasticizer bisphenol A perturbs the hepatic Ogilvie KA. epigenome: a systems level analysis of the miRNome. Unintended consequences of local alcohol restrictions in Genes (Basel) 2017; 8: 269. rural Alaska. J Ethn Subst Abuse 2017; online early: Ribeiro E, Ladeira C, Viegas S. doi: 10.1080/15332640.2017.1362728: Occupational exposure to bisphenol A (BPA): a reality that still needs to be unveiled. Okaru AO, Abuga KO, Kibwage IO, Lachenmeier DW. Toxics 2017; 5: 22. High ethanol contents of spirit drinks in Kibera slums, Kenya: implications for public health. Bisphenol S Foods 2017; 6: 89. Grandin F, Picard-Hagen N, Gayrard V, Puel S, Viguié C, Toutain P-L, Debrauwer L, Lacroix MZ. Omran AJA, Saternos HC, Althobaiti YS, Wisner A, Sari Y, Development of an on-line solid phase extraction ultra Nauli SM, AbouAlaiwi WA. performance liquid chromatography technique coupled to Alcohol consumption impairs the ependymal cilia motility tandem mass spectrometry for quantification of bisphenol S in the brain ventricles. and bisphenol S glucuronide: Applicability to toxicokinetic Sci Rep 2017; 7: 13652. investigations. J Chromatogr A 2017; online early: Shen C-J, Kao C-H, Hsu T-Y, Chen C-Y, Lin C-L, Shih H-M. doi: 10.1016/j.chroma.2017.10.020: Effect of alcohol intoxication on the risk of venous thromboembolism: a nationwide retrospective cohort study. Butane Medicine (Baltimore) 2017; 96: e8041. Sato T, Nishioka H, Tsuboi K, Katagi M, Miki A, Saito T,

Abe S, Nomura M, Kitagawa M, Tsuchihashi H, Suzuki K. Wang S, Sui S, Liu Z, Peng C, Liu J, Luo D, Fan X, Liu C, Lu W-Y. Detection of butane gas inhalation at 16 days after hypoxic encephalopathy: a case report. Protective roles of hepatic gamma-aminobutyric acid signaling in acute ethanol exposure-induced liver injury. Leg Med 2017; 29: 34-7. J Appl Toxicol 2017; online early: doi:10.1002/jat.3544: Carbon monoxide Wang Y-C, Yang K-W, Lee T-YP, Lin C-L, Liaw G-W, Hung Dos Santos E, Villa A, Garnier R, Dufayet L, Langrand J. D-Z, Kao C-H, Chen W-K, Yang T-Y. Surveillance and analysis of occupational carbon monoxide Increased risk of pyogenic liver abscess in patients with poisoning in the Paris region. alcohol intoxication: a population-based retrospective cohort Ann Work Expo Health 2017; 61: 986-93. study.

43

Ji JW. Int J Toxicol 2017; 36: 28S-30S. Acute compartment syndrome which causes rhabdomyolysis by carbon monoxide poisoning and sciatic Burnett CL. nerve injury associated with it: a case report. Methyldibromo glutaronitrile. Hip Pelvis 2017; 29: 204-9. Int J Toxicol 2017; 36: 39S-41S.

Law-Ye B, Dodet P, Hermann B, Trunet S, Dormont D, Burnett CL. Pyatigorskaya N, Leclercq D. Polyvinyl acetate. Progressive white-matter demyelination in delayed CO Int J Toxicol 2017; 36: 48S-9S. poisoning encephalopathy. J Neuroradiol 2017; online early: Burnett CL. doi: 10.1016/j.neurad.2017.09.008: HC red No. 1. Int J Toxicol 2017; 36: 32S-3S. Moon JM, Chun BJ, Shin MH, Lee SD. Serum N-terminal proBNP, not troponin I, at presentation Burnett CL. predicts long-term neurologic outcome in acute charcoal- PVP (Polyvinylpyrrolidone). burning carbon monoxide intoxication. Int J Toxicol 2017; 36: 50S-1S. Clin Toxicol 2017; online early: doi: 10.1080/15563650.2017.1394464: Burnett CL. Polyvinyl alcohol. Pasquier M, Dami F, Carron P-N, Yersin B, Pignel R, Hugli O. Int J Toxicol 2017; 36: 46S-7S. Mass casualty triage in the case of carbon monoxide poisoning: lessons learned. Burnett CL. Disaster Med Public Health Prep 2017; online early: doi: 4-Chlororesorcinol. 10.1017/dmp.2017.65: Int J Toxicol 2017; 36: 26S-7S.

Veronesi A, Pecoraro V, Zauli S, Ottone M, Leonardi G, Fischer A, Brodziak-Dopierala B, Loska K, Stojko J. Lauriola P, Trenti T. The assessment of toxic metals in plants used in cosmetics Use of carboxyhemoglobin as a biomarker of environmental and cosmetology. CO exposure: critical evaluation of the literature. Int J Environ Res Public Health 2017; 14: 1280. Environ Sci Pollut Res 2017; online early: doi: 10.1007/s11356-017-0270-1: Fiume M, Heldreth B. 40th anniversary overview and rereview summaries from Contrast media 2011 to 2015. Andreucci M, Faga T, Pisani A, Serra R, Russo D, De Sarro Int J Toxicol 2017; 36: 14S. G, Michael A. Quercetin protects against radiocontrast medium toxicity Fiume MM, Heldreth B, Boyer I, Bergfeld WF, Belsito DV, in human renal proximal tubular cells. Hill RA, Klaassen CD, Liebler DC, Marks JG, Jr., Shank RC, J Cell Physiol 2017; online early: doi: 10.1002/jcp.26213: Slaga TJ, Snyder PW, Andersen FA. Safety assessment of cross-linked alkyl acrylates as used Soares BP, Lequin MH, Huisman TAGM. in cosmetics. Safety of contrast material use in children. Int J Toxicol 2017; 36: 59S-88S. Magn Reson Imaging Clin N Am 2017; 25: 779-85. Fiume MM, Heldreth B, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, Marks JG, Jr., Shank RC, Slaga Corrosives TJ, Snyder PW, Andersen FA. Caganova B, Foltanova T, Puchon E, Ondriasova E, Safety assessment of diethanolamine and its salts as used Plackova S, Fazekas T, Kuzelova M. in cosmetics. Caustic ingestion in the elderly: influence of age on clinical Int J Toxicol 2017; 36: 89S-110S. outcome. Molecules 2017; 22: 1726. Fiume MM. Alpha hydroxy acids. Cosmetics Int J Toxicol 2017; 36: 15S-21S. Becker LC. HC yellow No. 4. Fiume MM. Int J Toxicol 2017; 36: 34S. 2-Amno-6-chloro-4-nitrophenol. Int J Toxicol 2017; 36: 22S-3S. Becker LC. HC orange No. 1. Fiume MM. Int J Toxicol 2017; 36: 31S. Isostearamidopropyl morpholine lactate. Int J Toxicol 2017; 36: 35S-6S. Becker LC. Quaternium-15. Fiume MM. Int J Toxicol 2017; 36: 52S. Bisabolol. Int J Toxicol 2017; 36: 24S-5S. Boyer IJ, Bergfeld WF, Heldreth B, Fiume MM, Gill LJ. The Cosmetic Ingredient Review Program–Expert safety Johnson W, Jr. assessments of cosmetic ingredients in an open forum. m-phenylenediamine and m-phenylenediamine sulfate. Int J Toxicol 2017; 36: 5S-13S. Int J Toxicol 2017; 36: 42S-3S.

Burnett CL. Johnson W, Jr. Glutaral. Iodopropynyl butylcarbamate.

44

Int J Toxicol 2017; 36: 37S-8S. Disinfectants Catlin NR, Willson CJ, Stout M, Kissling GE, Waidyanatha Johnson W, Jr. S, Baker GL, Hayden BK, Wyde M. Retinol and retinyl palmitate. Evaluation of the respiratory tract toxicity of ortho- Int J Toxicol 2017; 36: 53S-8S. phthalaldehyde, a proposed alternative for the chemical disinfectant glutaraldehyde. Mutlu E, Pierfelice J, McIntyre BS, Cunny HC, Kissling GE, Inhal Toxicol 2017; online early: Burback B, Waidyanatha S. doi: 10.1080/08958378.2017.1390015: Simultaneous quantitation of 2-hydroxy-4-methoxybenzo- phenone, a sunscreen ingredient, and its metabolites in Lee JH, Yu IJ. Harlan Sprague Dawley rat plasma following perinatal Human exposure to polyhexamethylene guanidine dietary exposure. phosphate from humidifiers in residential settings: cause of J Anal Toxicol 2017; online early: doi: 10.1093/jat/bkx070: serious lung disease. Toxicol Ind Health 2017; online early: Cyanoacrylate doi: 10.1177/0748233717724983:

Lee SH, Yun SJ, Ryu S, Choi SW, Kim HJ, Kang TK, Oh SC, Leem J-H, Lee J-H. Cho SJ. From specific Humidifier disinfectants disease to Humidifier Intentional cyanoacrylate ingestion: a rare cause of delayed disinfectants syndrome. gastric perforation requiring gastric wedge resection. Environ Health Toxicol 2017; online early: Am J Emerg Med 2017; online early: doi: 10.5620/eht.e2017017: doi: 10.1016/j.ajem.2017.10.017: Domoic acid Diacetyl Pérez-Gómez A, Cabrera-García D, Warm D, Marini AM, Galbraith DA. Salas Puig J, Fernández-Sánchez MT, Novelli A. Diacetyl and occupational bronchiolitis obliterans: comments Selective enhancement of domoic acid toxicity in primary on Rose, CS: EARLY DETECTION, CLINICAL DIAGNOSIS cultures of cerebellar granule cells by lowering extracellular AND MANAGEMENT OF LUNG DISEASE FROM EXPOSURE Na+ concentration. TO DIACETYL, Toxicology (2017), https://doi.org/10.1016/ Toxicol Sci 2017; online early: doi: 10.1093/toxsci/kfx201: j.tox.2017.03.019. Toxicology 2017; online early: Dust doi: 10.1016/j.tox.2017.10.009: Zeng X, Wu Y, Liu Z, Gao S, Yu Z. Occurence and distribution of organophosphate ester Dimethylnitrosamine flame retardants in indoor dust and their potential health El-Shenawy NS, Hamza RZ, Khaled HE. exposure risk. Protective effect of -lipoic acid against spleen toxicity of Environ Toxicol Chem 2017; online early: dimethylnitrosamine in male mice: antioxidant and doi: 10.1002/etc.3996: ultrastructure approaches. Biomed Pharmacother 2017; 96: 459-65. Dyes Gadaleta D, Porta N, Vrontaki E, Manganelli S, Manganaro Rani V, Verma Y, Rana K, Rana SVS. A, Sello G, Honma M, Benfenati E. Zinc oxide nanoparticles inhibit dimethylnitrosamine induced Integrating computational methods to predict mutagenicity liver injury in rat. of aromatic azo compounds. Chem Biol Interact 2017; online early: J Environ Sci Health [C] 2017; online early: doi: 10.1016/j.cbi.2017.10.009: doi: 10.1080/10590501.2017.1391521:

Dioxins E-cigarettes and e-liquids Beauval N, Antherieu S, Soyez M, Gengler N, Grova N, Fujisawa N, Yoshioka W, Yanagisawa H, Tohyama C. Howsam M, Hardy EM, Fischer M, Appenzeller BMR, Roles of cytosolic phospholipase A  in reproductive and 2 Goossens JF, Allorge D, Garçon G, Lo-Guidice J-M, Garat A. systemic toxicities in 2,3,7,8-tetrachlorodibenzo-p -dioxin- Chemical evaluation of electronic cigarettes: multicomponent exposed mice. analysis of liquid refills and their corresponding aerosols. Arch Toxicol 2017; online early: doi: 10.1007/s00204- J Anal Toxicol 2017; 41: 670-8. 017-2081-z:

Bengalli R, Ferri E, Labra M, Mantecca P. Huang C-Y, Lee C-C, Chang J-W, Cheng Y-Y, Kuo Y-C, Guo Lung toxicity of condensed aerosol from E-CIG liquids: H-R, Wu C-L. influence of the flavor and the in vitro model used. Association between dioxin and metabolic syndrome by Int J Environ Res Public Health 2017; 14: 1254. age and sex in an endemic area of exposure in Taiwan. Epidemiology 2017; 28 Suppl 1: S82-S88. Blundell MS, Dargan PI, Wood DM. A Cloud on the Horizon – A survey into the use of electronic Momeniha F, Faridi S, Amini H, Shamsipour M, Naddafi K, vaping devices for recreational drug and new psychoactive Yunesian M, Niazi S, Gohari K, Farzadfar F, Nabizadeh R, substance (NPS) administration. Mokammel A, Mahvi AH, Mesdaghinia A, Kashani H, QJM 2017; online early: doi: 10.1093/qjmed/hcx178: Nasseri S, Gholampour A, Saeedi R, Hassanvand MS. Estimating national dioxins and furans emissions, major Clapp PW, Jaspers I. sources, intake doses, and temporal trends in Iran from Electronic cigarettes: their constituents and potential links 1990–2010. to asthma. J Environ Health Sci Eng 2017; 15: 20. Curr Allergy Asthma Rep 2017; 17: 79.

45

Kosmider L, Kimber CF, Kurek J, Corcoran O, Dawkins LE. Razdan P, Patthi B, Kumar JK, Agnihotri N, Chaudhari P, Compensatory puffing with lower nicotine concentration e- Prasad M. liquids increases carbonyl exposure in e-cigarette aerosols. Effect of fluoride concentration in drinking water on Nicotine Tob Res 2017; online early: intelligence quotient of 12-14-year-old children in Mathura doi: 10.1093/ntr/ntx162: district: a cross-sectional study. J Int Soc Prev Community Dent 2017; 7: 252-8. Morley S, Slaughter J, Smith PR. Death from ingestion of e-liquid. Fragrance chemicals J Emerg Med 2017; online early: doi: 10.1016/j.jemermed.2017.06.029: Api AM, Belsito D, Botelho D, Browne D, Bruze M, Burton GA, Jr., Buschmann J, Dagli ML, Date M, Dekant W, Deodhar C, Francis M, Fryer AD, Joshi K, La Cava S, Lapczynski A, Liebler Endocrine disrupting chemicals DC, O'Brien D, Parakhia R, Patel A, Penning TM, Ritacco G, Buñay J, Larriba E, Patiño-Garcia D, Cruz-Fernandes L, Romine J, Salvito D, Schultz TW, Sipes IG, Thakkar Y, Castañeda-Zegarra S, Rodriguez-Fernandez M, Del Mazo J, Theophilus EH, Tiethof AK, Tokura Y. Moreno RD. RIFM fragrance ingredient safety assessment, beta- Differential effects of exposure to single versus a mixture of methylphenethyl alcohol, CAS registry number 1123-85-9. endocrine-disrupting chemicals on steroidogenesis pathway Food Chem Toxicol 2017; online early: in mouse testes. doi: 10.1016/j.fct.2017.09.056: Toxicol Sci 2017; online early: doi: 10.1093/toxsci/kfx200:

Api AM, Belsito D, Botelho D, Browne D, Bruze M, Burton GA, Petrakis D, Vassilopoulou L, Mamoulakis C, Psycharakis C, Jr., Buschmann J, Dagli ML, Date M, Dekant W, Deodhar C, Anifantaki A, Sifakis S, Docea AO, Tsiaoussis J, Makrigiannakis Francis M, Fryer AD, Joshi K, La Cava S, Lapczynski A, Liebler A, Tsatsakis AM. DC, O'Brien D, Parakhia R, Patel A, Penning TM, Ritacco G, Endocrine disruptors leading to obesity and related diseases. Romine J, Salvito D, Schultz TW, Sipes IG, Thakkar Y, Int J Environ Res Public Health 2017; 14: 1282. Theophilus EH, Tiethof AK, Tokura Y.

RIFM fragrance ingredient safety assessment, 2,2,5-trimethyl- Endotoxin 5-pentylcyclopentanone, CAS Registry Number 65443-14-3. Xu F, Wang F, Wen T, Sang W, He X, Li L, Zeng N. Food Chem Toxicol 2017; online early: Protective effect of cinnamic acid in endotoxin-poisoned mice. doi: 10.1016/j.fct.2017.10.009: Phytother Res 2017; online early: doi: 10.1002/ptr.5944: Api AM, Belsito D, Botelho D, Browne D, Bruze M, Burton GA, Ethylene glycol Jr., Buschmann J, Dagli ML, Date M, Dekant W, Deodhar C, Burman A, Watson CJE, Kosmoliaptsis V. Francis M, Fryer AD, Joshi K, La Cava S, Lapczynski A, Liebler Ethylene glycol poisoning should not contraindicate liver DC, O'Brien D, Parakhia R, Patel A, Penning TM, Ritacco G, donation. Romine J, Salvito D, Schultz TW, Sipes IG, Thakkar Y, Transplant Direct 2017; 3: e212. Theophilus EH, Tiethof AK, Tokura Y. RIFM fragrance ingredient safety assessment, alpha- Gaddam M, Velagapudi RK, Abu SE, Kanzy A. Isobutylphenethyl alcohol, CAS Registry Number 7779-78-4. Two gaps too many, three clues too few? Do elevated Food Chem Toxicol 2017; online early: osmolal and anion gaps with crystalluria always mean doi: 10.1016/j.fct.2017.10.012: ethylene glycol poisoning? BMJ Case Rep 2017; doi: 10.1136/bcr-2017-221739: Api AM, Belsito D, Botelho D, Browne D, Bruze M, Burton GA, Jr., Buschmann J, Dagli ML, Date M, Dekant W, Deodhar C, Flame retardants Francis M, Fryer AD, Joshi K, La Cava S, Lapczynski A, Liebler Krivoshiev BV, Beemster GTS, Sprangers K, Cuypers B, DC, O'Brien D, Parakhia R, Patel A, Penning TM, Ritacco G, Laukens K, Blust R, Husson SJ. Romine J, Salvito D, Schultz TW, Sipes IG, Thakkar Y, Toxicogenomics of the flame retardant tris (2-butoxyethyl) Theophilus EH, Tiethof AK, Tokura Y. phosphate in HepG2 cells using RNA-seq. RIFM fragrance ingredient safety assessment, 3-hexen-1-ol Toxicol In Vitro 2018; 46: 178-88. (isomer unspecified), CAS Registry Number 544-12-7. Food Chem Toxicol 2017; online early: Zeng X, Wu Y, Liu Z, Gao S, Yu Z. doi: 10.1016/j.fct.2017.10.013: Occurence and distribution of organophosphate ester flame retardants in indoor dust and their potential health Api AM, Belsito D, Botelho D, Browne D, Bruze M, Burton GA, exposure risk. Jr., Buschmann J, Dagli ML, Date M, Dekant W, Deodhar C, Environ Toxicol Chem 2017; online early: Francis M, Fryer AD, Joshi K, La Cava S, Lapczynski A, Liebler doi: 10.1002/etc.3996: DC, O'Brien D, Parakhia R, Patel A, Penning TM, Ritacco G, Romine J, Salvito D, Schultz TW, Sipes IG, Thakkar Y, Fluoride Theophilus EH, Tiethof AK, Tokura Y. Khandare AL, Gourineni SR, Validandi V. RIFM fragrance ingredient safety assessment, menthyl Dental fluorosis, nutritional status, kidney damage, and acetate (isomer unspecified), CAS Registry Number 16409- thyroid function along with bone metabolic indicators in 45-3. school-going children living in fluoride-affected hilly areas Food Chem Toxicol 2017; online early: of Doda district, Jammu and Kashmir, India. doi: 10.1016/j.fct.2017.10.014: Environ Monit Assess 2017; 189: 579. Api AM, Belsito D, Botelho D, Browne D, Bruze M, Burton GA, Kido T, Tsunoda M, Sugaya C, Hano H, Yanagisawa H. Jr., Buschmann J, Dagli ML, Date M, Dekant W, Deodhar C, Fluoride potentiates tubulointerstitial nephropathy caused Fryer AD, Joshi K, La Cava S, Lapczynski A, Liebler DC, by unilateral ureteral obstruction. O'Brien D, Parakhia R, Patel A, Penning TM, Ritacco G, Toxicology 2017; 392: 106-18. Romine J, Salvito D, Schultz TW, Sipes IG, Thakkar Y, Tokura Y, Tsang S, Wahler J.

46

RIFM fragrance ingredient safety assessment, dihydro-beta- Api AM, Belsito D, Botelho D, Browne D, Bruze M, Burton GA, ionol, cas registry number 3293-47-8. Jr., Buschmann J, Dagli ML, Date M, Dekant W, Deodhar C, Food Chem Toxicol 2017; online early: Francis M, Fryer AD, Joshi K, La Cava S, Lapczynski A, Liebler doi: 10.1016/j.fct.2017.10.010: DC, O'Brien D, Parakhia R, Patel A, Penning TM, Ritacco G, Romine J, Salvito D, Schultz TW, Sipes IG, Thakkar Y, Api AM, Belsito D, Botelho D, Browne D, Bruze M, Burton GA, Theophilus EH, Tiethof AK, Tokura Y. Jr., Buschmann J, Dagli ML, Date M, Dekant W, Deodhar C, RIFM fragrance ingredient safety assessment, cis-3-octen-1- Francis M, Fryer AD, Joshi K, La Cava S, Lapczynski A, Liebler ol, CAS Registry Number 20125-84-2. DC, O'Brien D, Parakhia R, Patel A, Penning TM, Ritacco G, Food Chem Toxicol 2017; online early: Romine J, Salvito D, Schultz TW, Sipes IG, Thakkar Y, doi: 10.1016/j.fct.2017.10.016: Theophilus EH, Tiethof AK, Tokura Y. RIFM fragrance ingredient safety assessment, cis-6-nonen-1- Api AM, Belsito D, Botelho D, Browne D, Bruze M, Burton GA, ol, CAS registry number 35854-86-5. Jr., Buschmann J, Dagli ML, Date M, Dekant W, Deodhar C, Food Chem Toxicol 2017; online early: Francis M, Fryer AD, Joshi K, La Cava S, Lapczynski A, Liebler doi: 10.1016/j.fct.2017.09.059: DC, O'Brien D, Parakhia R, Patel A, Penning TM, Ritacco G, Romine J, Salvito D, Schultz TW, Sipes IG, Thakkar Y, Api AM, Belsito D, Botelho D, Browne D, Bruze M, Burton GA, Theophilus EH, Tiethof AK, Tokura Y. Jr., Buschmann J, Dagli ML, Date M, Dekant W, Deodhar C, RIFM fragrance ingredient safety assessment, 2- Francis M, Fryer AD, Joshi K, La Cava S, Lapczynski A, Liebler pentylcyclopentan-1-one, CAS Registry Number 4819-67-4. DC, O'Brien D, Parakhia R, Patel A, Penning TM, Ritacco G, Food Chem Toxicol 2017; online early: Romine J, Salvito D, Schultz TW, Sipes IG, Thakkar Y, doi: 10.1016/j.fct.2017.10.016: Theophilus EH, Tiethof AK, Tokura Y. RIFM fragrance ingredient safety assessment, alpha- Raffalli C, Clouet E, Kuresepi S, Damiens M-H, Lepoittevin J-P, propylphenethyl alcohol, CAS registry number 705-73-7. Pallardy M, Ferret P-J, Giménez-Arnau E, Kerdine-Römer S. Food Chem Toxicol 2017; online early: Fragrance allergens linalool and limonene allylic doi: 10.1016/j.fct.2017.09.057: hydroperoxides in skin allergy: mechanisms of action focusing on transcription factor Nrf2. Api AM, Belsito D, Bhatia S, Botelho D, Browne D, Bruze M, Toxicol Sci 2017; online early: doi: 10.1093/toxsci/kfx207: Burton A, Jr., Buschmann J, Calow P, Dagli ML, Date M, Dekant W, Deodhar C, Fryer AD, Joshi K, Kromidas L, La Cava Furans S, Lalko JF, Lapczynski A, Liebler DC, Miyachi Y, O'Brien D, Momeniha F, Faridi S, Amini H, Shamsipour M, Naddafi K, Parakhia R, Patel A, Penning TM, Politano VT, Ritacco G, Yunesian M, Niazi S, Gohari K, Farzadfar F, Nabizadeh R, Romine J, Salvito D, Schultz TW. Mokammel A, Mahvi AH, Mesdaghinia A, Kashani H, RIFM fragrance ingredient safety assessment, tetrahydro-4- Nasseri S, Gholampour A, Saeedi R, Hassanvand MS. methyl-2-(2-methylpropen-1-yl)pyran, CAS Registry Number Estimating national dioxins and furans emissions, major 16409-43-1. sources, intake doses, and temporal trends in Iran from Food Chem Toxicol 2017; online early: 1990–2010. doi: 10.1016/j.fct.2017.10.011: J Environ Health Sci Eng 2017; 15: 20.

Api AM, Belsito D, Botelho D, Browne D, Bruze M, Burton GA, Jr., Buschmann J, Dagli ML, Date M, Dekant W, Deodhar C, Glycol ethers Francis M, Fryer AD, Joshi K, La Cava S, Lapczynski A, Liebler Warembourg C, Botton J, Lelong N, Rouget F, Khoshnood DC, O'Brien D, Parakhia R, Patel A, Penning TM, Ritacco G, B, Le GF, Monfort C, Labat L, Pierre F, Heude B, Slama R, Romine J, Salvito D, Schultz TW, Sipes IG, Thakkar Y, Multigner L, Charles MA, Cordier S, Garlantezec R. Theophilus EH, Tiethof AK, Tokura Y. Prenatal exposure to glycol ethers and cryptorchidism and RIFM fragrance ingredient safety assessment, hypospadias: a nested case-control study. methylcyclooctyl carbonate, CAS registry number 61699-38-5. Occup Environ Med 2017; online early: Food Chem Toxicol 2017; online early: doi: 10.1136/oemed-2017-104391: doi: 10.1016/j.fct.2017.09.046: Hydrogen sulphide Api AM, Belsito D, Botelho D, Browne D, Bruze M, Burton GA, Imamura F, Cooper TK, Hasegawa-Ishii S, Sonobe T, Jr., Buschmann J, Dagli ML, Date M, Dekant W, Deodhar C, Haouzi P. Francis M, Fryer AD, Joshi K, La Cava S, Lapczynski A, Liebler Hydrogen sulfide specifically alters Nad(P)H quinone DC, O'Brien D, Parakhia R, Patel A, Penning TM, Ritacco G, dehydrogenase 1 (Nqo1) olfactory neurons in the rat. Romine J, Salvito D, Schultz TW, Sipes IG, Thakkar Y, Neuroscience 2017; online early: Theophilus EH, Tiethof AK, Tokura Y. doi: 10.1016/j.neuroscience.2017.10.014: RIFM fragrance ingredient safety assessment, 3,7-dimethyl- 2,6-nonadienenitrile, CAS registry number 61792-11-8. Iminothiazolidinones Food Chem Toxicol 2017; online early: doi: 10.1016/j.fct.2017.09.047: Tugcu FT, Turhan K, Karadayi M, Gulluce M. Genotoxic evaluation of newly synthesized iminothiazol- idinones. Api AM, Belsito D, Botelho D, Browne D, Bruze M, Burton GA, Jr., Buschmann J, Dagli ML, Date M, Dekant W, Deodhar C, Toxicol Ind Health 2017; online early: Francis M, Fryer AD, Joshi K, La Cava S, Lapczynski A, Liebler doi: 10.1177/0748233717730492: DC, O'Brien D, Parakhia R, Patel A, Penning TM, Ritacco G, Romine J, Salvito D, Schultz TW, Sipes IG, Thakkar Y, Isocyanates Theophilus EH, Tiethof AK, Tokura Y. Hu J, Cantrell P, Nand A. RIFM fragrance ingredient safety assessment, alpha- Comprehensive biological monitoring to assess isocyanates methylbenzyl alcohol, CAS registry number 98-85-1. and solvents exposure in the NSW Australia motor vehicle Food Chem Toxicol 2017; online early: repair industry. doi: 10.1016/j.fct.2017.09.045: Ann Work Expo Health 2017; 61: 1015-23.

47

Methanol doi: 10.1080/17435390.2017.1388864: Barroso J, Díez-Buitrago B, Saa L, Möller M, Briz N, Pavlov V. Specific bioanalytical optical and photoelectrochemical Poudel BK, Park JH, Lim J, Byeon JH. assays for detection of methanol in alcoholic beverages. Direct fluorescent labeling for efficient biological assessment Biosens Bioelectron 2018; 101: 116-22. of inhalable particles. Nanotoxicology 2017; online early: Klein KA, Warren AK, Baumal CR, Hedges TR, III. doi: 10.1080/17435390.2017.1378748: Optical coherence tomography findings in methanol toxicity. Int J Retina Vitreous 2017; 3: 36. Pujalte I, Serventi A, Noel A, Dieme D, Haddad S, Bouchard M. Characterization of aerosols of titanium dioxide Mineral fibres nanoparticles following three generation methods using an Black B, Dodson RF, Bruce JR, Poye LW, Henschke C, optimized aerosolization system designed for experimental Loewen G. inhalation studies. A clinical assessment and lung tissue burden from an Toxics 2017; 5: 14. individual who worked as a Libby vermiculite miner. Inhal Toxicol 2017; online early: Scott-Fordsmand JJ, Peijnenburg WJGM, Semenzin E, doi: 10.1080/08958378.2017.1372536: Nowack B, Hunt N, Hristozov D, Marcomini A, Irfan M-A, Jiménez AS, Landsiedel R, Tran L, Oomen AG, Bos PMJ, Hund-Rinke K. Escriva L, Manyes L, Font G, Berrada H. Environmental risk assessment strategy for nanomaterials. Mycotoxin analysis of human urine by LC-MS/MS: a Int J Environ Res Public Health 2017; 14: 1251. comparative extraction study. Toxins (Basel) 2017; 9: 27. Senapati VA, Kansara K, Shanker R, Dhawan A, Kumar A. Monitoring characteristics and genotoxic effects of Nanoparticles engineered nanoparticle-protein corona. Mutagenesis 2017; 32: 479-90. Assadian E, Zarei MH, Gilani AG, Farshin M, Degampanah

H, Pourahmad J. Wang X, Liu Y, Wang J, Nie Y, Chen S, Hei TK, Deng Z, Toxicity of copper oxide (CuO) nanoparticles on human Wu L, Zhao G, Xu A. blood lymphocytes. Amplification of arsenic genotoxicity by TiO nanoparticles Biol Trace Elem Res 2017; online early: 2 in mammalian cells: new insights from physicochemical doi: 10.1007/s12011-017-1170-4: interactions and mitochondria.

Nanotoxicology 2017; online early: Choo WH, Moon B, Song S, Oh SM. doi: 10.1080/17435390.2017.1388861: Morphological transformation induced by silver nanoparticles in Balb/c 3T3 A31-1-1 mouse cell model to evaluate in vitro Yan M, Yang C, Huang B, Huang Z, Huang L, Zhang X, carcinogenic potential. Zhao C. Environ Health Toxicol 2017; online early: Systemic toxicity induced by aggregated layered double doi: 10.5620/eht.e2017016: hydroxide nanoparticles.

Int J Nanomedicine 2017; 12: 7183-95. De Matteis V.

Exposure to inorganic nanoparticles: routes of entry, immune response, biodistribution and in vitro/in vivo Nitric oxide toxicity evaluation. Anderson SM, Naidoo RN, Ramkaran P, Phulukdaree A, Toxics 2017; 5: 29. Muttoo S, Asharam K, Chuturgoon AA. The effect of nitric oxide pollution on oxidative stress in DeLoid GM, Wang Y, Kapronezai K, Lorente LR, Zhang R, pregnant women living in Durban, South Africa. Pyrgiotakis G, Konduru NV, Ericsson M, White JC, Torre- Arch Environ Contam Toxicol 2017; online early: doi: Roche R, Xiao H, McClements DJ, Demokritou P. 10.1007/s00244-017-0465-y: An integrated methodology for assessing the impact of food matrix and gastrointestinal effects on the biokinetics Nitromethane and cellular toxicity of ingested engineered nanomaterials. Powell D, Hassall L, Scholes D, Al-Jubouri M. Part Fibre Toxicol 2017; 14: 40. False acute kidney injury alert due to model car fuel ingestion. Gulumian M, Andraos C. BMJ Case Rep 2017; doi: 10.1136/bcr-2017-221134: In search of a converging cellular mechanism in nano- toxicology and nanomedicine in the treatment of cancer. Toxicol Pathol 2017; online early: Nonylphenol doi: 10.1177/0192623317735776: Tang L, Zhao B, Zhang H, Du Q, Zhu J, Zhao Z, Chen C, Luo C, Kang Q, Yuan W, Bian S, Bi H, Sun H, Li Y. He T, Long J, Li J, Liu L, Cao Y. Regulation of nonylphenol-induced reproductive toxicity in Toxicity of ZnO nanoparticles (NPs) to A549 cells and mouse spermatogonia cells by miR-361-3p. A549 epithelium in vitro: Interactions with dipalmitoyl Mol Reprod Dev 2017; online early: doi: 10.1002/mrd.22923: phosphatidylcholine (DPPC). Environ Toxicol Pharmacol 2017; 56: 233-40. Ozone Goodman JE, Zu K, Loftus CT, Lynch HN, Prueitt RL, Onoda A, Takeda K, Umezawa M. Mohar I, Shubin SP, Sax SN. Pretreatment with N-acetyl cysteine suppresses chronic Short-term ozone exposure and asthma severity: weight- reactive astrogliosis following maternal nanoparticle of-evidence analysis. exposure during gestational period. Environ Res 2017; 160: 391-7. Nanotoxicology 2017; online early:

48

Perfluorooctanesulfonic acid Radiation Pierozan P, Karlsson O. Bhandari T, Babaran W, Forouzannia A, Williams V, PFOS induces proliferation, cell-cycle progression, and Harness J, Carpenter M, Gobran M, Khanijou R, Wagman malignant phenotype in human breast epithelial cells. B, Ash R, Wagman LD. Arch Toxicol 2017; online early: doi: 10.1007/s00204-017- A prospective phase I comparison of toxicity and cosmesis 2077-8: outcomes of single-fraction IORT and hypofractionated radiotherapy with IORT boost in early-stage breast cancer. Phosphorus Brachytherapy 2017; online early: doi: 10.1016/j.brachy.2017.09.002: Dharanipradab M, Viswanathan S, Kumar GR, Krishnamurthy V, Stanley DD. Elmhiri G, Gloaguen C, Grison S, Kereselidze D, Elie C, Yellow phosphorus-induced Brugada phenocopy. Tack K, Benderitter M, Lestaevel P, Legendre A, Souidi M. J Electrocardiol 2017; online early: DNA methylation and potential multigenerational epigenetic doi: 10.1016/j.jelectrocard.2017.08.033: effects linked to uranium chronic low-dose exposure in gonads of males and females rats. Phthalates Toxicol Lett 2017; online early: Andersen FA. doi: 10.1016/j.toxlet.2017.10.004: Dibutyl, dimethyl, and diethyl phthalate and butyl benzyl phthalate. Moller S, Munck Af RP, Costa J, Law I, Poulsen HS, Int J Toxicol 2017; 36: 44S-5S. Engelholm SA, Engelholm S. Toxicity and efficacy of re-irradiation of high-grade glioma Huang Y, Garcia JM, Shu W, Rong H, Zhang L, Wang Y, in a phase I dose- and volume escalation trial. Tan Y, Lin H, Zeng H, Chen JA. Radiother Oncol 2017; online early: Peroxisome proliferator activated receptor gamma in doi: 10.1016/j.radonc.2017.09.039: human placenta may mediate the adverse effects of phthalates exposure in pregnancy. Stoppel G, Eich H-T, Matuschek C, Kortmann R-D, Meyer F, Martinsson U, Nilsson K, Kristensen I, Vordermark D, Reprod Toxicol 2017; online early: Willich N, Christiansen H, Koch R, Steinmann D. doi: 10.1016/j.reprotox.2017.10.001: Lung toxicity after radiation in childhood: results of the

International Project on Prospective Analysis of Radiotoxicity Ma T, Yin X, Han R, Ding J, Zhang H, Han X, Li D. in Childhood and Adolescence. Effects of in utero exposure to di-n-butyl phthalate on Radiother Oncol 2017; online early: testicular development in rat. doi: 10.1016/j.radonc.2017.09.026: Int J Environ Res Public Health 2017; 14: 1284. Wang K, Pearlstein KA, Patchett ND, Deal AM, Mavroidis P, Polybrominated diphenyl ethers Jensen BC, Lipner MB, Zagar TM, Wang Y, Lee CB, Eblan Ermilova I, Stenberg S, Lyubartsev AP. MJ, Rosenman JG, Socinski MA, Stinchcombe TE, Marks LB. Quantum chemical and molecular dynamics modelling of Heart dosimetric analysis of three types of cardiac toxicity hydroxylated polybrominated diphenyl ethers. in patients treated on dose-escalation trials for Stage III Phys Chem Chem Phys 2017; online early: non-small-cell lung cancer. doi: 10.1039/c7cp03471g: Radiother Oncol 2017; online early: doi: 10.1016/j.radonc.2017.10.001:

Polycyclic aromatic hydrocarbons Wilke C, Grosshans D, Duman J, Brown P, Li J. Huang M, Mesaros CA, Hackfield LC, Hodge RP, Blair IA, Radiation-induced cognitive toxicity: Pathophysiology and Penning TM. interventions to reduce toxicity in adults. Potential metabolic activation of representative alkylated Neuro Oncol 2017; online early: polycyclic aromatic hydrocarbons 1-methylphenanthrene doi: 10.1093/neuonc/nox195: and 9-ethylphenanthrene associated with the Deepwater Horizon oil spill in human hepatoma (HepG2) cells. Yamauchi M, Sakuma S. Chem Res Toxicol 2017; online early: Development of bioassay system for evaluation of doi: 10.1021/acs.chemrestox.7b00232: materials for personal protective equipment (PPE) against toxic effects of ionizing radiations. Keir JLA, Akhtar US, Matschke DMJ, Kirkham TL, Chan HM, Ind Health 2017; online early: doi: 10.2486/indhealth.2017- Ayotte P, White PA, Blais JM. 0128: Elevated exposures to polycyclic aromatic hydrocarbons and other organic mutagens in Ottawa firefighters participating Radon in emergency, on-shift fire suppression. Huang H, Ji Y, Zhang J, Su Z, Liu M, Tong J, Ge C, Chen T, Environ Sci Technol 2017; online early: Li J. doi: 10.1021/acs.est.7b02850: Aberrant DNA methylation in radon and/or cigarette smoke-induced malignant transformation in BEAS-2B Samburova V, Zielinska B, Khlystov A. human lung cell line. Do 16 polycyclic aromatic hydrocarbons represent PAH air J Toxicol Environ Health A 2017; online early: oxicity? doi: 10.1080/15287394.2017.1384156: Toxics 2017; 5: 17. Shiga toxins Polyvinyl acetate Park J-Y, Jeong Y-J, Park S-K, Yoon S-J, Choi S, Jeong DG, Burnett CL. Chung SW, Lee BJ, Kim JH, Tesh VL, Lee M-S, Park Y-J. Polyvinyl acetate. Shiga toxins induce apoptosis and ER stress in human Int J Toxicol 2017; 36: 48S-9S. retinal pigment epithelial cells. Toxins (Basel) 2017; 9: 319.

49

Fowler CD, Gipson CD, Kleykamp BA, Rupprecht LE, Harrell Silicates PT, Rees VW, Gould TJ, Oliver J, Bagdas D, Damaj MI, Jeanneau C, Laurent P, Rombouts C, Giraud T, About I. Schmidt HD, Duncan A, De Biasi M, Basic Science Network Light-cured tricalcium silicate toxicity to the dental pulp. (BSN) of the Society for Research on Nicotine and Tobacco J Endod 2017; online early: (SRNT). doi: 10.1016/j.joen.2017.07.010: Basic science and public policy: informed regulation for nicotine and tobacco products. Nicotine Tob Res 2017; online early: Siloxanes doi: 10.1093/ntr/ntx175: Liu N, Xu L, Cai Y.

Methyl siloxanes in barbershops and residence indoor dust Huang H, Ji Y, Zhang J, Su Z, Liu M, Tong J, Ge C, Chen T, and the implication for human exposures. Li J. Sci Total Environ 2017; online early: Aberrant DNA methylation in radon and/or cigarette smoke- doi: 10.1016/j.scitotenv.2017.09.250: induced malignant transformation in BEAS-2B human lung

cell line. Solvents J Toxicol Environ Health A 2017; online early: doi: Hu J, Cantrell P, Nand A. 10.1080/15287394.2017.1384156: Comprehensive biological monitoring to assess isocyanates and solvents exposure in the NSW Australia motor vehicle Ji M, Zhang Y, Li N, Wang C, Xia R, Zhang Z, Wang S-L. repair industry. Nicotine component of cigarette smoke extract (CSE) Ann Work Expo Health 2017; 61: 1015-23. decreases the cytotoxicity of CSE in BEAS-2B cells stably expressing human cytochrome P450 2A13. Talc Int J Environ Res Public Health 2017; 14: 1221. Finkelstein MM. Re: Brent L. Finley, Stacey M. Benson & Gary M. Marsh Lee PN, Thornton AJ. (2017): Cosmetic talc as a risk factor for pleural The relationship of snus use to diabetes and allied conditions. mesothelioma: a weight of evidence evaluation of the Regul Toxicol Pharmacol 2017; online early: epidemiology, Inhalation Toxicology, DOI: 10.1080/ doi: 10.1016/j.yrtph.2017.10.017: 08958378.2017.1336187. Inhal Toxicol 2017; online early: Narkowicz S, Jaszczak E, Polkowska Z, Kielbratowska B, doi: 10.1080/08958378.2017.1385662: Kotlowska A, Namiesnik J. Determination of thiocyanate as a biomarker of tobacco Mirabelli D. smoke constituents in selected biological materials of human Letter on: "Cosmetic talc as a risk factor for pleural origin. mesothelioma: a weight of evidence evaluation of the Biomed Chromatogr 2017; online early: epidemiology". doi: 10.1002/bmc.4111: Inhal Toxicol 2017; 29: 341.

Park S-H, Ko J-W, Shin N-R, Shin D-H, Cho Y-K, Seo C-S, Kim Terpenes J-C, Kim J-S, Shin I-S. Meehan-Atrash J, Luo W, Strongin RM. 4-Hydroxycinnamic acid protects mice from cigarette smoke- Toxicant formation in dabbing: the terpene story. induced pulmonary inflammation via MAPK pathways. ACS Omega 2017; 2: 6112-7. Food Chem Toxicol 2017; 110: 151-5.

Tobacco Platt DE, Hariri E, Salameh P, Helou M, Sabbah N, Merhi Al-Sawalha NA, Al-Bo'ul HF, Alzoubi KH, Khabour OF, M, Chammas E, Ammar W, Abchee AB, Zalloua PA. Thanawala VJ. Association of waterpipe smoking with myocardial infarction Effect of prenatal waterpipe tobacco smoke on airway and determinants of metabolic syndrome among inflammation in murine model of asthma of adult offspring catheterized patients. mice. Inhal Toxicol 2017; online early: Inhal Toxicol 2017; 29: 366-73. doi: 10.1080/08958378.2017.1384085:

Berman ML, Bickel WK, Harris AC, LeSage MG, O'Connor Weitzman M. RJ, Stepanov I, Shields PG, Hatsukami DK. American Pediatric Society's 2017 John Howland award Consortium on methods evaluating tobacco: research tools acceptance lecture: A tale of two toxicants-childhood to inform FDA regulation of snus. exposure to lead and tobacco. Nicotine Tob Res 2017; online early: Pediatr Res 2017; online early: doi: 10.1038/pr.2017.240: doi: 10.1093/ntr/ntx228:

Cooperman NA, Lu S-E, Richter KP, Bernstein SL, Williams JM. Toluene Pilot Study of a tailored smoking cessation intervention for Afravy M, Angali K, Khodadadi A, Ahmadizadeh M. individuals in treatment for opioid dependence. The protective effect of Buffalo's milk against toluene Nicotine Tob Res 2017; online early: induced-nephrotoxicity in rats. doi: 10.1093/ntr/ntx189: J Nephropathol 2017; 6: 174-9.

Faulkner P, Petersen N, Ghahremani DG, Cox CM, Tyndale Cao X-L, Pelletier L, Sparling M, Dabeka R. RF, Hellemann GS, London ED. Occurrence of toluene in Canadian total diet foods and its Sex differences in tobacco withdrawal and responses to significance to overall human exposure. smoking reduced-nicotine cigarettes in young smokers. Food Addit Contam Part A Chem Anal Control Expo Risk Psychopharmacology 2017; online early: Assess 2017; online early: doi: 10.1007/s00213-017-4755-x: doi: 10.1080/19440049.2017.1395520:

50

Toluene diisocyanate Aluminium Prueitt RL, Lynch HN, Zu K, Shi L, Goodman JE. Klotz K, Weistenhofer W, Neff F, Hartwig A, Van Thriel C, Dermal exposure to toluene diisocyanate and respiratory Drexler H. cancer risk. The health effects of aluminum exposure. Environ Int 2017; online early: Dtsch Arztebl Int 2017; 114: 653-9. doi: 10.1016/j.envint.2017.09.017: Li L, Jiao Y, Jin T, Sun H, Li S, Jin C, Hu S, Ji J, Xiang L. Trichloroethylene Phenolic alkaloid oleracein E attenuates oxidative stress Abdraboh ME, Abdeen SH, Salama M, Elhussiny M, El- and neurotoxicity in AlCl3-treated mice. Sherbini YM, Eldeen NM. Life Sci 2017; online early: doi: 10.1016/j.lfs.2017.10.019: Developmental neurotoxic effects of a low dose of TCE on 3D neurosphere system. Arsenic Biochem Cell Biol 2017; online early: doi: 10.1139/bcb- Gao Y, Baisch P, Mirlean N, Rodrigues da Silva Júnior FM, 2017-0089: Van Larebeke N, Baeyens W, Leermakers M. Arsenic speciation in fish and shellfish from the North Sea Heydari M, Ahmadizadeh M, Ahmadi Angali K. (Southern bight) and Açu Port area (Brazil) and health Ameliorative effect of vitamin E on trichloroethylene- risks related to seafood consumption. induced nephrotoxicity in rats. Chemosphere 2018; 191: 89-96. J Nephropathol 2017; 6: 168-73. Guvvala PR, Ravindra JP, Rajani CV, Sivaram M, Selvaraju S. Zhang J-X, Li N, Wang H, Shen T, Zhu Q-X. Protective role of epigallocatechin-3-gallate on arsenic The immune response in trichloroethylene hypersensitivity induced testicular toxicity in Swiss albino mice. syndrome: a review. Biomed Pharmacother 2017; 96: 685-94. Toxicol Ind Health 2017; online early: doi: 10.1177/0748233717731213: Ledda C, Iavicoli I, Bracci M, Avola R, Senia P, Santarelli L, Pomara C, Rapisarda V. Vermiculite Serum lipid, lipoprotein, and apolipoprotein profiles in workers exposed to low arsenic levels: lipid profiles and Black B, Dodson RF, Bruce JR, Poye LW, Henschke C, Loewen G. occupational arsenic exposure. A clinical assessment and lung tissue burden from an Toxicol Lett 2017; online early: individual who worked as a Libby vermiculite miner. doi: 10.1016/j.toxlet.2017.10.014: Inhal Toxicol 2017; online early: doi: 10.1080/08958378.2017.1372536: Müller SM, Ebert F, Raber G, Meyer S, Bornhorst J, Hüwel S, Galla H-J, Francesconi KA, Schwerdtle T. Effects of arsenolipids on in vitro blood-brain barrier model. METALS Arch Toxicol 2017; online early: doi: 10.1007/s00204-017- General 2085-8: Bjørklund G, Mutter J, Aaseth J. Metal chelators and neurotoxicity: lead, mercury, and Wang X, Liu Y, Wang J, Nie Y, Chen S, Hei TK, Deng Z, arsenic. Wu L, Zhao G, Xu A. Arch Toxicol 2017; online early: doi: 10.1007/s00204-017- Amplification of arsenic genotoxicity by TiO2 nanoparticles 2100-0: in mammalian cells: new insights from physicochemical interactions and mitochondria.

Nanotoxicology 2017; online early: Fischer A, Brodziak-Dopierala B, Loska K, Stojko J. doi: 10.1080/17435390.2017.1388861: The assessment of toxic metals in plants used in cosmetics and cosmetology. Int J Environ Res Public Health 2017; 14: 1280. Cadmium Abarikwu SO, Njoku RC, Lawrence CJ, Charles IA, Huang Y-C, Chang W-C, Shan Y-H, Lin C-Y, Wang C-L, Dai Ikewuchi JC. C-Y, Ho C-K, Wu M-T, Chuang H-Y. Rutin ameliorates oxidative stress and preserves hepatic Toxic metals increase serum tumor necrosis factor-alpha and renal functions following exposure to cadmium and levels, modified by essential elements and different types ethanol. of tumor necrosis factor-alpha promoter single-nucleotide Pharm Biol 2017; 55: 2161-9. polymorphisms. Epidemiology 2017; 28 Suppl 1: S113-S120. Byber K, Lison D, Verougstraete V, Dressel H, Hotz P. Response to letter to the editor from Elinder and Nordberg Protano C, Astolfi ML, Canepari S, Andreoli R, Mutti A, concerning Byber et al. 2016. Cadmium or cadmium Valeriani F, Romano S, V, Antonucci A, Mattei V, Martellucci compounds and chronic kidney disease in workers and the S, Vitali M. general population: a systematic review, Crit Rev Toxicol. Exposure to individual and multiple carcinogenic metals 46(3):191-240. DOI: 0.3109/10408444.2015.1076375. during paediatric age: an experience from an Italian urban Crit Rev Toxicol 2017; online early: scenario. doi: 10.1080/10408444.2017.1375899: Ann Ig 2017; 29: 494-503. Saleh RM, Awadin WF. Riaz MA, Akhtar ABT, Riaz A, Mujtaba G, Ali M, Ijaz B. Biochemical and histopathological changes of subacute Heavy metals identification and exposure at workplace cadmium intoxication in male rats. environment its extent of accumulation in blood of iron Environ Sci Pollut Res Int 2017; online early: doi: and steel recycling foundry workers of Lahore, Pakistan. 10.1007/s11356-017-0348-9: Pak J Pharm Sci 2017; 30: 1233-8. Wang H, Zhang L, Abel GM, Storm DR, Xia Z.

51

Cadmium exposure impairs cognition and olfactory memory in male C57BL/6 mice. Newman NC, Elam S, Igoe C, Jones C, Menrath W, Porter Toxicol Sci 2017; online early: doi: 10.1093/toxsci/kfx202: D, Haynes EN. A community–academic partnership to reduce lead exposure Chromium from an elevated roadway demolition, Cincinnati, Ohio, 2012. Thompson CM, Kirman CR, Hays SM, Suh M, Harvey SE, Public Health Rep 2017; online early: Proctor DM, Rager JE, Haws LC, Harris MA. doi: 10.1177/0033354917732756: Integration of mechanistic and pharmacokinetic information to derive oral reference dose and margin-of- Sabbar M, Dkhissi-Benyahya O, Benazzouz A, Lakhdar- exposure values for hexavalent chromium. Ghazal N. J Appl Toxicol 2017; online early: doi: 10.1002/jat.3545: Circadian clock protein content and daily rhythm of locomotor ativity are altered after chronic exposure to lead in rat. Cobalt Front Behav Neurosci 2017; 11: 178. Kumar V, Mishra RK, Kaur G, Dutta D. Cobalt and nickel impair DNA metabolism by the oxidative Schmidt CW. stress independent pathway. After the screening: what happens next for children with Metallomics 2017; online early: doi: 10.1039/c7mt00231a: elevated blood lead? Environ Health Perspect 2017; 125: 102001. Lead Weitzman M. Alvarez-Ortega N, Caballero-Gallardo K, Olivero-Verbel J. Low blood lead levels impair intellectual and hematological American Pediatric Society's 2017 John Howland award function in children from Cartagena, Caribbean coast of acceptance lecture: A tale of two toxicants-childhood Colombia. exposure to lead and tobacco. J Trace Elem Med Biol 2017; 44: 233-40. Pediatr Res 2017; online early: doi: 10.1038/pr.2017.240:

Duan Y, Peng L, Shi H, Jiang Y. Wen L, Jiang X, Sun J, Li X, Li X, Tian L, Li Y, Bai W. The effects of lead on GABAergic interneurons in rodents. Cyanidin-3-O-glucoside promotes the biosynthesis of Toxicol Ind Health 2017; online early: progesterone through the protection of mitochondrial function doi: 10.1177/0748233717732902: in Pb-exposed rat leydig cells. Food Chem Toxicol 2017; online early: Engstrom AK, Xia Z. doi: 10.1016/j.fct.2017.10.008: Lead exposure in late adolescence through adulthood impairs short-term spatial memory and the neuronal Ying X, Gao Z-Y, Yan J, Zhang M, Wang J, Xu J, Markowitz differentiation of adult-born cells in C57BL/6 male mice. M, Yan C-H. Neurosci Lett 2017; 661: 108-13. Sources, symptoms and characteristics of childhood lead poisoning: experience from a lead specialty clinic in China. Handley MA, Nelson K, Sanford E, Clarity C, Emmons-Bell Clin Toxicol 2017; online early: S, Gorukanti A, Kennelly P. doi: 10.1080/15563650.2017.1391392: Examining lead exposures in California through state- issued health alerts for food contamination and an Zhang X-L, McGlothan JL, Miry O, Stansfield KH, Loth MK, exposure-based candy testing program. Stanton PK, Guilarte TR. Environ Health Perspect 2017; 125: 104503. 7,8-Dihydroxyflavone rescues lead-induced impairment of vesicular release: a novel therapeutic approach for lead Hauptman M, Woolf AD. intoxicated children. Lead poisoning and children in foster care: diagnosis and Toxicol Sci 2017; online early: doi: 10.1093/toxsci/kfx210: management challenges. Clin Pediatr 2017; online early: doi: 10.1177/0009922817734364: Lithium Shanks G, Mishra V, Nikolova S. Hauptman M, Bruccoleri R, Woolf AD. Endocrine abnormalities in lithium toxicity. An update on childhood lead poisoning. Clin Med 2017; 17: 434-6. Clin Pediatr Emerg Med 2017; 18: 181-92. Mercury Hayatbakhsh MM, Oghabian Z, Conlon E, Nakhaee S, Al-Zubaidi ES, Rabee AM. Amirabadizadeh AR, Zahedi MJ, Darvish Moghadam S, The risk of occupational exposure to mercury vapor in Ahmadi B, Soroush S, Aaseth J, Mehrpour O. some public dental clinics of Baghdad city, Iraq. Lead poisoning among opium users in Iran: an emerging Inhal Toxicol 2017; online early: health hazard. doi: 10.1080/08958378.2017.1369601: Subst Abuse Treat Prev Policy 2017; 12: 43.

Hon KL, Fung CK, Leung AK. Dao CV, Shiraishi M, Miyamoto A. Childhood lead poisoning: an overview. The MARCKS protein amount is differently regulated by Hong Kong Med J 2017; online early: calpain during toxic effects of methylmercury between SH- doi: 10.12809/hkmj176214: SY5Y and EA.hy926 cells. J Vet Med Sci 2017; online early: doi: 10.1292/jvms.17-0473: Juric AK, Batal M, David W, Sharp D, Schwartz H, Ing A, Fediuk K, Black A, Tikhonov C, Chan HM, Chan L. Fujimura M, Usuki F. Risk assessment of dietary lead exposure among First In situ different antioxidative systems contribute to the Nations people living on-reserve in Ontario, Canada using site-specific methylmercury neurotoxicity in mice. a total diet study and a probabilistic approach. Toxicology 2017; 392: 55-63. J Hazard Mater 2017; 344: 55-63.

52

Kleffner I, Eichler S, Ruck T, Schüngel L, Pfeuffer S, Polzer DNA methylation and potential multigenerational epigenetic P, Dittrich R, Dziewas R, Gross CC, Göbel K, Wiendl H, effects linked to uranium chronic low-dose exposure in Kehrel BE, Meuth SG. gonads of males and females rats. An enigmatic case of acute mercury poisoning: clinical, Toxicol Lett 2017; online early: immunological findings and platelet function. doi: 10.1016/j.toxlet.2017.10.004: Front Neurol 2017; 8: 517. Vanadium Rebelo FM, da Cunha LR, Andrade PD, da Costa Junior Wilk A, Szypulska-Koziarska D, Wiszniewska B. WA, Bastos WR, Caldas ED. The toxicity of vanadium on gastrointestinal, urinary and Mercury in breast milk from women in the Federal District, reproductive system, and its influence on fertility and Brazil and dietary risk assessment for breastfed infants. fetuses malformations. J Trace Elem Med Biol 2017; 44: 99-103. Postepy Hig Med Dosw (Online) 2017; 71: 850-9.

Spiller HA. Rethinking mercury: the role of selenium in the patho- Zinc physiology of mercury toxicity. Riccò M, Cattani S, Signorelli C. Clin Toxicol 2017; online early: Zinc exposure for female workers in a galvanizing plant in doi: 10.1080/15563650.2017.1400555: Northern Italy. Int J Occup Med Environ Health 2017; online early: doi: Wang X, Han L, Li G, Peng W, Gao X, Klaassen CD, Fan G, 10.13075/ijomeh.1896.00878: Zhang Y. Identification of natural products as inhibitors of human PESTICIDES organic anion transporters (OAT1 and OAT3) and their protective effect on mercury-induced toxicity. General Toxicol Sci 2017; online early: doi: 10.1093/toxsci/kfx216: Chowdhury FR, Dewan G, Verma VR, Knipe DW, Isha IT, Faiz MA, Gunnell DJ, Eddleston M. Weinhouse C, Ortiz EJ, Berky AJ, Bullins P, Hare-Grogg J, Bans of WHO class I pesticides in Bangladesh—Suicide Rogers L, Morales A-M, Hsu-Kim H, Pan WK. prevention without hampering agricultural output. Hair mercury level is associated with anemia and Int J Epidemiol 2017; online early: micronutrient status in children living near artisanal and doi: 10.1093/ije/dyx157: small-scale gold mining in the Peruvian Amazon. Am J Trop Med Hyg 2017; online early: Damalas CA, Koutroubas SD. doi: 10.4269/ajtmh.17-0269: Farmers' training on pesticide use Is associated with elevated safety behavior. Yorifuji T, Kashima S, Suryadhi MAH, Abudureyimu K. Toxics 2017; 5: 19. Temporal trends of infant and birth outcomes in Minamata after severe methylmercury exposure. Hilgert Jacobsen-Pereira C, Dos Santos CR, Troina Maraslis Environ Pollut 2017; online early: F, Pimentel L, Feijo AJL, Iomara Silva C, de Medeiros GDS, doi: 10.1016/j.envpol.2017.09.060: Costa Zeferino R, Curi Pedrosa R, Weidner Maluf S. Markers of genotoxicity and oxidative stress in farmers exposed to pesticides. Nickel Ecotoxicol Environ Saf 2017; 148: 177-83. Kumar V, Mishra RK, Kaur G, Dutta D. Cobalt and nickel impair DNA metabolism by the oxidative Manyilizu WB, Mdegela RH, Helleve A, Skjerve E, Kazwala stress independent pathway. R, Nonga H, Muller MHB, Lie E, Lyche J. Metallomics 2017; online early: doi: 10.1039/c7mt00231a: Self-reported symptoms and pesticide use among farm workers in Arusha, northern Tanzania: a cross sectional Song X, Fiatikenston SS, Kong L, Zhao J. study. Molecular mechanisms of nickel induced neurotoxicity and Toxics 2017; 5: 24. chemoprevention. Toxicology 2017; 392: 47-54. Pesticides and cancer Verma H, Sharma T, Gupta S, Banerjee BD. Silver CYP1A1 expression and organochlorine pesticides level in Choo WH, Moon B, Song S, Oh SM. the etiology of bladder cancer in North Indian population. Morphological transformation induced by silver nanoparticles Hum Exp Toxicol 2017; online early: in Balb/c 3T3 A31-1-1 mouse cell model to evaluate in vitro doi: 10.1177/0960327117734623: carcinogenic potential. Environ Health Toxicol 2017; online early: doi: 10.5620/eht.e2017016: Bipyridyl herbicides Gawarammana I, Buckley NA, Mohamed F, Naser K, Jeganathan K, Ariyananada PL, Wunnapuk K, Dobbins TA, Thallium Tomenson JA, Wilks MF, Eddleston M, Dawson AH. Jiang Y, Xia W, Zhang B, Pan X, Liu W, Jin S, Huo W, Liu High-dose immunosuppression to prevent death after H, Peng Y, Sun X, Zhang H, Zhou A, Xu S, Li Y. paraquat self-poisoning – a randomised controlled trial. Predictors of thallium exposure and its relation with Clin Toxicol 2017; online early: preterm birth. doi: 10.1080/15563650.2017.1394465: Environ Pollut 2017; online early: doi: 10.1016/j.envpol.2017.09.080: Hu L, Li H, Cai Z, Lin F, Hong G, Chen H, Lu Z. A new machine-learning method to prognosticate paraquat Uranium poisoned patients by combining coagulation, liver, and Elmhiri G, Gloaguen C, Grison S, Kereselidze D, Elie C, kidney indices. Tack K, Benderitter M, Lestaevel P, Legendre A, Souidi M. PLoS ONE 2017; 12: e0186427.

53

Food Addit Contam Part A Chem Anal Control Expo Risk Jamshidi F, Fathi G, Davoodzadeh H. Assess 2017; online early: Investigation paraquat poisoning in southwest of Iran - doi: 10.1080/19440049.2017.1376120: from sign to mortality and morbidity. Arch Med Sadowej Kryminol 2017; 67: 35-45. Insecticides (general)

Ferdinand N, Herman NV, Omer Bebe NK, Augustave K, Liu Z, Sun M, Wang Y, Zhang L, Zhao H, Zhao M. Valence M, Ghislaine NT, Herve T, Dorice AK, Sorelle D, Silymarin attenuated paraquat-induced cytotoxicity in Yacouba M. macrophage by regulating Trx/TXNIP complex, inhibiting Antouka Super® induced oxidative stress and reproductive NLRP3 inflammasome activation and apoptosis. toxicity in male Japanese quail (Coturnix coturnix japonica). Toxicol In Vitro 2017; online early: Heliyon 2017; 3: e00410. doi: 10.1016/j.tiv.2017.10.017:

Lapied B. Lohitnavy M, Chitsakhon A, Jomprasert K, Lohitnavy O, Editorial: Insecticide mode of action: from insect to Reisfeld B. mammalian toxicity. Development of a physiologically based pharmacokinetic Curr Med Chem 2017; 24: 2910-1. model of paraquat.

Conf Proc IEEE Eng Med Biol Soc 2017; 2017: 2732-5. Dimethoate Zhu Y, Deng G, Ji A, Yao J, Meng X, Wang J, Wang Q, Saleh Al-Awthan Y, Ali Al-Duais M, Abdulfatah Hazeb A, Wang Q, Wang R. Ahmed Alril W. Porous Se@SiO2 nanospheres treated paraquat-induced Protective role of Achillea biebersteinii pretreatment on acute lung injury by resisting oxidative stress. dimethoate induced oxidative stress in guinea pigs liver. Int J Nanomedicine 2017; 12: 7143-52. Pak J Biol Sci 2017; 20: 403-9.

Fungicides Metaldehyde Heise T, Schmidt F, Knebel C, Rieke S, Haider W, Geburek Fernández-Torre JL, Paramio-Paz A, Rodríguez-Borregán JC, I, Niemann L, Marx-Stoelting P. Orizaola P, Bosque-Varela P, Hernández-Hernández MA. Hepatotoxic combination effects of three azole fungicides Super-refractory nonconvulsive status epilepticus due to in a broad dose range. self-poisoning with metaldehyde. Arch Toxicol 2017; online early: doi: 10.1007/s00204-017- J Clin Neurosci 2017; online early: 2087-6: doi: 10.1016/j.jocn.2017.10.017:

Benalaxyl Neonicotinoids Wang X, Wang D, Zhou Z, Zhu W. Babel'ová J, Šefcíková Z, Cikoš Š, Špirková A, Kovaríková Subacute oral toxicity assessment of benalaxyl in mice V, Koppel J, Makarevich AV, Chrenek P, Fabian D. based on metabolomics methods. Exposure to neonicotinoid insecticides induces embryotoxicity Chemosphere 2018; 191: 373-80. in mice and rabbits. Toxicology 2017; 392: 71-80. Herbicides Chiew AL, Page CB, Clancy D, Mostafa A, Roberts MS, Hirano T, Yanai S, Takada T, Yoneda N, Omotehara T, Isbister GK. Kubota N, Minami K, Yamamoto A, Mantani Y, Yokoyama 2-Methyl-4-chlorophenoxyacetic acid (MCPA) and T, Kitagawa H, Hoshi N. bromoxynil herbicide ingestion. NOAEL-dose of a neonicotinoid pesticide, clothianidin, Clin Toxicol 2017; online early: acutely induce anxiety-related behavior with human-audible doi: 10.1080/15563650.2017.1385790: vocalizations in male mice in a novel environment. Toxicol Lett 2017; online early: Atrazine doi: 10.1016/j.toxlet.2017.10.010:

Morgan AM, Ibrahim MA, Hussien AM. Wang X, Anadón A, Qinghua W, Qiao F, Ares I, Martínez- The potential protective role of Akropower against Atrazine- Larrañaga M-R, Yuan Z, Martínez M-A. induced humoral immunotoxicity in rabbits. Mechanism of neonicotinoid toxicity: impact on oxidative Biomed Pharmacother 2017; 96: 710-5. stress and metabolism.

Annu Rev Pharmacol Toxicol 2017; online early: doi: Bentazone 10.1146/annurev-pharmtox-010617-052429: Lee K. A fatal case of acute bentazone overdose despite Thiacloprid cricothyroidotomy during cardiopulmonary resuscitation. Zuercher P, Gerber D, Schai N, Nebiker M, König S, Clin Exp Emerg Med 2017; online early: Schefold JC. doi: 10.15441/ceem.15.056: Calypso's spell: accidental near-fatal thiacloprid intoxication.

Clin Case Rep 2017; 5: 1672-5. Glyphosate

Baier CJ, Gallegos CE, Raisman-Vozari R, Minetti A. Organochlorine pesticides Behavioral impairments following repeated intranasal Endosulfan glyphosate-based herbicide administration in mice. Ghosh K, Chatterjee B, Jayaprasad AG, Kanade SR. Neurotoxicol Teratol 2017; 64: 63-72. The persistent organochlorine pesticide endosulfan modulates multiple epigenetic regulators with oncogenic potential in Stephenson CL, Harris CA, Clarke R. MCF-7 cells. An assessment of the acute dietary exposure to Sci Total Environ 2017; online early: glyphosate using deterministic and probabilistic methods. doi: 10.1016/j.scitotenv.2017.10.058:

54

Myopia and exposure to organophosphate and pyrethroid Magni PA, Pazzi M, Vincenti M, Converso V, Dadour IR. pesticides in the general United States population. Development and validation of a method for the detection Invest Ophthalmol Vis Sci 2017; 58: 4915-24. of alpha- and beta-endosulfan (organochlorine insecticide) in Calliphora vomitoria (diptera: calliphoridae). Allethrin J Med Entomol 2017; online early: doi: 10.1093/jme/tjx177: Madhubabu G, Yenugu S. Exposure to allethrin-based mosquito coil smoke during Lindane gestation and postnatal development affects reproductive Palmerini MG, Zhurabekova G, Balmagambetova A, function in male offspring of rat. Nottola SA, Miglietta S, Belli M, Bianchi S, Cecconi S, Di Inhal Toxicol 2017; 29: 374-85. Nisio V, Familiari G, Macchiarelli G. The pesticide lindane induces dose-dependent damage to Rodenticides granulosa cells in an in vitro culture. Reprod Biol 2017; online early: Tetramethylenedisulfotetramine doi: 10.1016/j.repbio.2017.09.008: Pressly B, Nguyen HM, Wulff H. GABAA receptor subtype selectivity of the proconvulsant rodenticide TETS. Organophosphorus insecticides Arch Toxicol 2017; online early: doi: 10.1007/s00204- General 017-2089-4: Anon. Medical devices; clinical chemistry and clinical toxicology Thallium devices; classification of the organophosphate test system. Jiang Y, Xia W, Zhang B, Pan X, Liu W, Jin S, Huo W, Liu Final order. H, Peng Y, Sun X, Zhang H, Zhou A, Xu S, Li Y. Fed Regist 2017; 82: 48413-5. Predictors of thallium exposure and its relation with preterm birth. Comfort N, Re DB. Environ Pollut 2017; online early: Sex-specific neurotoxic effects of organophosphate pesticides doi: 10.1016/j.envpol.2017.09.080: across the life course. Curr Environ Health Rep 2017; online early: doi: 10.1007/s40572-017-0171-y: CHEMICAL WARFARE,

Jaber BM, Petroianu GA, Rizvi SA, Borai A, Saleh NA, Hala BIOLOGICAL WARFARE AND SM, Saleh AM. RIOT CONTROL AGENTS Protective effect of metoclopramide against organo- phosphate-induced apoptosis in the murine skin fibroblast Biological warfare L929. Ricin J Appl Toxicol 2017; online early: doi: 10.1002/jat.3543: Gal Y, Mazor O, Falach R, Sapoznikov A, Kronman C, Sabo T. Treatments for pulmonary ricin intoxication: current Migneron-Foisy V, Bouchard MF, Freeman EE, Saint-Amour D. aspects and future prospects. Myopia and exposure to organophosphate and pyrethroid Toxins (Basel) 2017; 9: 311. pesticides in the general United States population. Invest Ophthalmol Vis Sci 2017; 58: 4915-24. Lopez Nunez OF, Pizon AF, Tamama K. Ricin poisoning after oral ingestion of castor beans: a case Mohammadi H, Jalilian J, Karimi MY, Shetab-Boushehri SV. report and review of the literature and laboratory testing. In vitro cysteine reactivates organophosphate insecticide J Emerg Med 2017; online early: dichlorvos-inhibited human cholinesterases. doi: 10.1016/j.jemermed.2017.08.023: Sultan Qaboos Univ Med J 2017; 17: e293-e300. Merkley ED, Jenson SC, Arce JS, Melville AM, Leiser OP, Sánchez MBS, Hernández Valdivieso AM, Villanueva MÁM, Wunschel DS, Wahl KL. Salazar AFZ. Ricin-like proteins from the castor plant do not influence Potential clinical application of surface electromyography liquid chromatography-mass spectrometry detection of as indicator of neuromuscular recovery during weaning ricin in forensically relevant samples. tests after organophosphate poisoning. Toxicon 2017; online early: Rev Bras Ter Intensiva 2017; 29: 253-8. doi: 10.1016/j.toxicon.2017.10.004:

Takayasu T, Yamamoto H, Ishida Y, Nosaka M, Kawaguchi Sun J-F, Wang C, Shao B, Wang Z, Xue D, Liu Y, Niu Y. M, Kuninaka Y, Kimura A, Kondo T. Fast on-site visual detection of active ricin using a Postmortem distribution of chlorpyrifos-methyl, fenitrothion, combination of high efficient dual-recognition affinity and their metabolites in body fluids and organ tissues of an magnetic enrichment and a specific AuNP probe. intoxication case. Anal Chem 2017; online early: Leg Med (Tokyo) 2017; 29: 44-50. doi: 10.1021/acs.analchem.7b02944:

Chlorpyrifos Vance DJ, Tremblay JM, Rong Y, Angalakurthi SK, Volkin Van Emon JM, Pan P, van Breukelen F. DB, Middaugh CR, Weis DD, Shoemaker CB, Mantis NJ. Effects of chlorpyrifos and trichloropyridinol on HEK 293 High-resolution epitope positioning of a large collection of human embryonic kidney cells. neutralizing and non-neutralizing single domain antibodies Chemosphere 2018; 191: 537-47. on ricin toxin's enzymatic and binding subunits. Clin Vaccine Immunol 2017; online early: doi: 10.1128/CVI.00236-17: Pyrethroid insecticides General Whitfield SJC, Griffiths GD, Jenner DC, Gwyther RJ, Stahl Migneron-Foisy V, Bouchard MF, Freeman EE, Saint-Amour D. FM, Cork LJ, Holley JL, Green AC, Clark GC.

55

Production, characterisation and testing of an ovine antitoxin against ricin; efficacy, potency and mechanisms of Chaubey K, Alam SI, Nagar DP, Waghmare CK, Pant SC, action. Singh L, Srivastava N, Bhattacharya BK. Toxins (Basel) 2017; 9: 329. Proteome profile of different rat brain regions after sarin intoxication. Chemical warfare Toxicol Sci 2017; 160: 136-49. General James T, Wyke S, Marczylo T, Collins S, Gaulton T, Foxall VX K, Amlôt R, Duarte-Davidson R. Lydon H, Hall C, Matar H, Dalton C, Chipman JK, Graham Chemical warfare agent simulants for human volunteer JS, Chilcott RP. trials of emergency decontamination: a systematic review. The percutaneous toxicokinetics of VX in a damaged skin porcine model and the evaluation of WoundStat as a J Appl Toxicol 2017; online early: doi: 10.1002/jat.3527: ™ topical decontaminant.

J Appl Toxicol 2017; online early: doi: 10.1002/jat.3542: Mustard gas Iman M, Rezaei R, Azimzadeh-Jamalkandi S, Shariati P, Kheradmand F, Salimian J. PLANTS Th17/Treg immunoregulation and implications in treatment Abrus precatorius (Jequirity) of sulfur mustard gas-induced lung diseases. Tam CC, Cheng LW, He X, Merrill P, Hodge D, Stanker LH. Exp Rev Clin Immunol 2017; online early: A monoclonal-monoclonal antibody based capture ELISA doi: 10.1080/1744666X.2017.1389646: for abrin. Toxins (Basel) 2017; 9: 328. Zhao S, Xi H, Zuo Y, Wang Q, Wang Z, Yan Z. Bicarbonate-activated hydrogen peroxide and efficient Tam CC, Henderson TD, Stanker LH, He X, Cheng LW. decontamination of toxic sulfur mustard and nerve gas Abrin toxicity and bioavailability after temperature and pH simulants. treatment. J Hazard Mater 2018; 344: 136-45. Toxins (Basel) 2017; 9: 320.

Nerve agents Atropa belladonna (Deadly nightshade) Lackovic Z. Bonichon M, Combès A, Desoubries C, Bossée A, Pichon V. "Bunanje": XX century abuse of Atropa belladonna Development of immunosorbents coupled on-line to halucinogenic berries in continental Croatia. immobilized pepsin reactor and micro liquid chromatog- Psychiatr Danub 2017; 29: 379-82. raphy-tandem mass spectrometry for analysis of butyrylcholinesterase in human plasma. J Chromatogr A 2017; online early: Averrhoa carambola (Star fruit) doi: 10.1016/j.chroma.2017.10.033: Tsai J-L, Tsai S-F. Star fruit Intoxication in a patient undergoing regular Bonichon M, Valbi V, Combès A, Desoubries C, Bossée A, hemodialysis. Pichon V. Ther Apher Dial 2017; online early: doi: 10.1111/1744- 9987.12588: Online coupling of immunoextraction, digestion, and microliquid chromatography-tandem mass spectrometry for the analysis of sarin and -butyrylcholinesterase Caryocar brasiliense (Pequi) adducts in human plasma. Traesel GK, de Lima FF, dos Santos AC, Souza RIC, Anal Bioanal Chem 2017; online early: doi: 10.1007/s00216- Cantadori DT, Kretschmer CR, Navarini VJ, Oesterreich SA. 017-0640-z: Evaluation of embryotoxic and teratogenic effects of the oil extracted from Caryocar brasiliense Cambess pulp in rats. Niessen KV, Seeger T, Rappengluck S, Wein T, Höfner G, Food Chem Toxicol 2017; 110: 74-82. Wanner KT, Thiermann H, Worek F. In vitro pharmacological characterization of the bispyridinium Curcuma longa (Turmeric) non-oxime compound MB327 and its 2- and 3-regioisomers. Lasoff DR, Cantrell FL, Ly BT. Toxicol Lett 2017; online early: Death associated with intravenous turmeric (Curcumin) doi: 10.1016/j.toxlet.2017.10.009: preparation. Clin Toxicol 2017; online early: Tanimoto T, Oshima Y, Yuji K, Ozaki A, Kami M. doi: 10.1080/15563650.2017.1388387: Organophosphate poisoning and terrorism. Malays J Med Sci 2017; 24: 111-2. Datura spp. Beynon SJ, Chaturvedi S. Vilela SMF, Salcedo-Abraira P, Colinet I, Salles F, de Datura intoxication in an adolescent male: a challenge in Koning MC, Joosen MJA, Serre C, Horcajada P. the Internet era.

Nanometric MIL-125-NH2 metal-organic framework as a J Paediatr Child Health 2017; online early: potential nerve agent antidote carrier. doi: 10.1111/jpc.13726: Nanomaterials (Basel) 2017; 7: 321. Digitalis spp. (Foxglove) Zhao S, Xi H, Zuo Y, Wang Q, Wang Z, Yan Z. Hughes A, Hendrickson RG, Chen BCC, Valento M. Bicarbonate-activated hydrogen peroxide and efficient Letter in response to "fatal cardiac glycoside poisoning decontamination of toxic sulfur mustard and nerve gas due to mistaking foxglove for comfrey". simulants. Clin Toxicol 2017; online early: J Hazard Mater 2018; 344: 136-45. doi: 10.1080/15563650.2017.1398329:

56

Euphorbia spp. Shields M, Andrew N, LaHood B, Saha N. Paralytic shellfish poisoning Eye injuries following ocular exposure to euphorbia plant Eangoor P, Indapurkar AS, Vakkalanka M, Yeh JS, Knaack JS. sap: an Australian and New Zealand case series. Rapid and sensitive ELISA screening assay for several Clin Exp Ophthalmol 2017; online early: paralytic shellfish toxins in human urine. doi: 10.1111/ceo.13081: J Anal Toxicol 2017; online early: doi: 10.1093/jat/bkx072:

Mitragyna speciosa (Kratom) Suleiman M, Jelip J, Rundi C, Chua TH. Case report: paralytic shellfish poisoning in Sabah, Malaysia. Halpenny GM. Am J Trop Med Hyg 2017; online early: Mitragyna speciosa: balancing potential medical benefits doi: 10.4269/ajtmh.17-0589: and abuse.

ACS Med Chem Lett 2017; 8: 897-9. Ixodes holocyclus (Australian Mushrooms and other fungi paralysis tick) Berntsen HF, Bogen IL, Wigestrand MB, Fonnum F, Karbanowicz T, Dover E, Mu X, Tabor A, Rodriguez-Valle M. Walaas SI, Moldes-Anaya A. Extracellular expression of the HT1 neurotoxin from the The fungal neurotoxin penitrem A induces the production of Australian paralysis tick in two Saccharomyces cerevisiae reactive oxygen species in human neutrophils at strains. submicromolar concentrations. Toxicon 2017; 140: 1-10. Toxicology 2017; 392: 64-70. Microorganisms Sharma D, Singh VP, Singh NK. Zhang L, Meng X, Xiang Z, Li D, Han X. A review on phytochemistry and of Roles of mmu_piR_003399 in microcystin-leucine arginine medicinal as well as poisonous mushrooms. (MC-LR)-induced reproductive toxicity in the spermatogonial Mini Rev Med Chem 2017; online early: cells and testis. doi: 10.2174/1389557517666170927144119: Toxicol Sci 2017; online early: doi: 10.1093/toxsci/kfx209:

Xiang H, Zhou Y, Zhou C, Lei S, Yu H, Wang Y, Zhu S. Menezes C, Churro C, Dias E. Investigation and analysis of Galerina sulciceps poisoning in Risk levels of toxic cyanobacteria in Portuguese recreational a canteen. freshwaters. Clin Toxicol 2017; online early: Toxins (Basel) 2017; 9: 327. doi: 10.1080/15563650.2017.1388386: Botulism Polygonum multiflorum (Tuber Beske PH, Bradford AB, Hoffman KM, Mason S, McNutt PM. fleeceflower) In vitro and ex vivo screening of candidate therapeutics to Lin L, Li H, Lin H, Zhang M, Qu C, Yan L, Yin X, Ni J. restore neurotransmission in nerve terminals intoxicated Application of iTRAQ-based quantitative proteomics by botulinum neurotoxin serotype A1. approach to identify deregulated proteins associated with Toxicon 2017; online early: liver toxicity Induced by Polygonum multiflorum in rats. doi: 10.1016/j.toxicon.2017.10.017: Cell Physiol Biochem 2017; 43: 2102-16. López de la Paz M, Scheps D, Jurk M, Hofmann F, Frevert J. Ricinus communis (Castor oil plant) Rational design of A1 mutants with improved oxidative stability. Lopez Nunez OF, Pizon AF, Tamama K. Toxicon 2017; online early: Ricin poisoning after oral ingestion of castor beans: a case doi: 10.1016/j.toxicon.2017.10.011: report and review of the literature and laboratory testing.

J Emerg Med 2017; online early: Rossetto O. doi: 10.1016/j.jemermed.2017.08.023: The binding of botulinum neurotoxins to different peripheral neurons. Spartium junceum (Spanish broom) Toxicon 2017; online early: Giménez N, Magro N, Cortés N, Guitart R. doi: 10.1016/j.toxicon.2017.10.010: Poisoning after ingestion of Spartium junceum seeds: dose-dependent effects in three boys. Xue S, Seki H, Remes M, Šilhár P, Janda K. J Emerg Med 2017; 53: e41-e44. Examination of alpha-exosite inhibitors against Botulinum neurotoxin A protease through structure-activity relationship studies of chicoric acid. ANIMALS Bioorg Med Chem Lett 2017; online early: Fish/marine poisoning doi: 10.1016/j.bmcl.2017.10.021: Kiriake A, Ishizaki S, Nagashima Y, Shiomi K. Occurrence of a stonefish toxin-like toxin in the venom of the rabbitfish Siganus fuscescens. Dokur M, Dogan M, Yagmur EA. Toxicon 2017; online early: Scorpion-related cardiomyopathy and acute pulmonary doi: 10.1016/j.toxicon.2017.10.015: edema in a child who is stung by Leiurus abdullahbayrami. Turk J Emerg Med 2017; 17: 104-8. Ciguatera Litaker RW, Holland WC, Hardison DR, Pisapia F, Hess P, Kang AM, Brooks DE. Kibler SR, Tester PA. Geographic distribution of scorpion exposures in the Ciguatoxicity of Gambierdiscus and Fukuyoa species from United States, 2010–2015. the Caribbean and Gulf of Mexico. Am J Public Health 2017; online early: PLoS ONE 2017; 12: e0185776. doi: 10.2105/AJPH.2017.304094:

57

Allergic reactions to antivenom in a patient bitten twice by McElroy T, McReynolds CN, Gulledge A, Knight KR, Smith the same snake within a month: a rare case report and WE, Albrecht EA. literature review. Differential toxicity and venom gland gene expression in Chin J Traumatol 2017; online early: Centruroides vittatus. doi: 10.1016/j.cjtee.2016.12.004: PLoS ONE 2017; 12: e0184695. Crotalinae (Pit vipers) Nait Mohamed FA, Nouri A, Laraba-Djebari F. Baudou FG, Litwin S, Lanari LC, Laskowicz RD, Damin CF, Reactogenicity and safety assessment of an attenuated Chippaux J-P, de Roodt AR. nanovaccine against scorpion envenomation: Preclinical study. Antivenom against Crotalus durissus terrificus venom: Vaccine 2017; online early: immunochemical reactivity and experimental neutralizing doi: 10.1016/j.vaccine.2017.10.028: capacity. Toxicon 2017; online early: Reddy CR, Bompelli N, Khardenavis V, Deshpande A. doi: 10.1016/j.toxicon.2017.10.009: Scorpion bite-induced ischaemic stroke. BMJ Case Rep 2017; doi: 10.1136/bcr-2017-221606: Lazo F, Vivas-Ruiz DE, Sandoval GA, Rodríguez EF, Kozlova EEG, Costal-Oliveira F, Chávez-Olórtegui C, Snake bites Severino R, Yarlequé A, Sanchez EF. Harrison RA, Oluoch GO, Ainsworth S, Alsolaiss J, Bolton Biochemical, biological and molecular characterization of F, Arias A-S, Gutiérrez J-M, Rowley P, Kalya S, Ozwara H, an L-Amino acid oxidase (LAAO) purified from Bothrops Casewell NR. pictus Peruvian snake venom. Preclinical antivenom-efficacy testing reveals potentially Toxicon 2017; 139: 74-86. disturbing deficiencies of snakebite treatment capability in East Africa. Tan CH, Liew JL, Tan NH, Khaldun IA, Maharani T, PLoS Negl Trop Dis 2017; 11: e0005969. Khomvilai S, Sitprija V. Cross reactivity and lethality neutralization of venoms of Jenkins TP, Sánchez A, Segura Á, Vargas M, Herrera M, Indonesian Trimeresurus complex species by Thai Green Stewart TK, León G, Gutiérrez JM. Pit Viper Antivenom. An improved technique for the assessment of venom- Toxicon 2017; online early: induced haemorrhage in a murine model. doi: 10.1016/j.toxicon.2017.10.014: Toxicon 2017; 139: 87-93. Elapidae Ruha A-M, Kleinschmidt KC, Greene S, Spyres MB, Brent J, van Nguyen T, Osipov AV. Wax P, Padilla-Jones A, Campleman S, On behalf of the A study of ribonuclease activity in venom of vietnam ToxIC Snakebite Study Group. cobra. PMC5611641. The epidemiology, clinical course, and management of J Anim Sci Technol 2017; 59: 20. snakebites in the North American snakebite registry. J Med Toxicol 2017; online early: doi: 10.1007/s13181-017- 0633-5: Viperinae (True vipers) Karabuva S, Lukšic B, Brizic I, Latinovic Z, Leonardi A, Shaikh IK, Dixit PP, Pawade BS, Waykar IG. Križaj I. Development of dot-ELISA for the detection of venoms of Ammodytin L is the main cardiotoxic component of the major Indian venomous . Vipera ammodytes ammodytes venom. Toxicon 2017; online early: Toxicon 2017; 139: 94-100. doi: 10.1016/j.toxicon.2017.10.007: Vulfius CA, Kasheverov IE, Kryukova EV, Spirova EN, Dunbar JP, Afoullouss S, Sulpice R, Dugon MM. Shelukhina IV, Starkov VG, Andreeva TV, Faure G, Envenomation by the noble false widow spider Steatoda Zouridakis M, Tsetlin VI, Utkin YN. nobilis (Thorell, 1875) – Five new cases of steatodism from Pancreatic and snake venom presynaptically active Ireland and Great Britain. phospholipases A2 inhibit nicotinic acetylcholine receptors. Clin Toxicol 2017; online early: PLoS ONE 2017; 12: e0186206. doi: 10.1080/15563650.2017.1393084:

Zeng F-J, Chen C, Liu M-H.

INDEX

1,3-butadiene ...... 41 Aluminium ...... 50 Abrin ...... 41 Amfetamines ...... 29 Abrus precatorius ...... 55 Aminoglycosides ...... 29 Acetaminophen ...... 38 Amiodarone ...... 29 Acetylcysteine ...... 25, 29 Anaesthetics...... 29 Acrylamide ...... 41 Analytical toxicology ...... 11 Aflatoxins ...... 41 Animals, general ...... 56 Air pollution ...... 40 Anorexiant drugs ...... 29 Alcohol ...... 41 Antiarrhythmic drugs ...... 29 Allethrin ...... 54 Antibiotics ...... 29 Alpha-lipoic acid ...... 26 Anticoagulants...... 29

58

Anticonvulsants ...... 30 Dextromethorphan ...... 33 Antidotes ...... 25 Diacetyl ...... 44 Antifungal drugs ...... 30 Diacetylmorphine...... 34 Antimalarial drugs ...... 30 Dietary supplements ...... 33 Antineoplastic drugs ...... 30 Digitalis spp...... 55 Antipsychotics ...... 32 Dimethoate ...... 53 Antivenom ...... 25 Dimethylnitrosamine ...... 44 Antiviral drugs ...... 32 Dioxins ...... 44 Apixaban ...... 29 Disinfectants ...... 44 Arsenic ...... 50 Dolutegravir ...... 32 Articaine ...... 29 Domoic acid ...... 44 Astaxanthin ...... 26 Doxorubicin ...... 31 Atrazine ...... 53 Driving under the influence ...... 15 Atropa belladonna ...... 55 Drugs, general ...... 27 Australian paralysis tick ...... 56 Dust ...... 44 Averrhoa carambola ...... 55 Dyes ...... 44 Baclofen ...... 26, 32 E-cigarettes and e-liquids ...... 44 Benalaxyl ...... 53 Ecstasy ...... 29 Bentazone ...... 53 Elapidae ...... 57 Benzbromarone ...... 32 Endocrine disrupting chemicals ...... 45 Benzene ...... 42 Endosulfan ...... 53 Beta-blockers ...... 32 Endotoxin ...... 45 Biological warfare...... 54 Epidemiology...... 15 Biomarkers ...... 13 Epigallocatechin-3-gallate ...... 26 Bipyridyl herbicides ...... 52 Erlotinib ...... 31 Bisphenol A ...... 42 Estrogen ...... 33 Bisphenol S...... 42 Ethanol ...... 41 Botulism ...... 56 Ethnic remedies ...... 33 Buprenorphine ...... 26 Ethylene glycol ...... 45 Butane ...... 42 Euphorbia spp...... 56 Cadmium ...... 50 Exhaust fumes ...... 40 Caffeine...... 32 Extracorporeal treatments ...... 26 Calciferol ...... 40 Fentanyl...... 38 Cannabis ...... 32 Fish/marine poisoning ...... 56 Capecitabine ...... 31 Flame retardants ...... 45 Capsaicin ...... 26 Fluoride ...... 45 Carbamazepine ...... 30 Fluoxetine ...... 39 Carbon monoxide ...... 42 Forensic toxicology ...... 15 Carcinogenicity ...... 13 Foxglove ...... 55 Cardiotoxicity ...... 13 Fragrance chemicals ...... 45 Carfentanil ...... 38 Fungicides ...... 53 Caryocar brasiliense ...... 55 Furans ...... 46 Castor oil plant ...... 56 Gabapentin ...... 30 Catecholamines...... 33 Gamma hydroxybutyrate ...... 33 Chelating agents ...... 25 Genotoxicity ...... 16 Chemical incidents ...... 40 Ginseng ...... 26, 33 Chemical warfare, general ...... 55 Glycol ethers ...... 46 Chemicals, general ...... 40 Glyphosate ...... 53 Chlorpyrifos ...... 54 Hazardous waste ...... 40 Chromium ...... 51 Heparin ...... 30 Ciguatera ...... 56 Hepatotoxicity ...... 16 Cisplatin ...... 31 Herbal medicines ...... 33 Clozapine...... 32 Herbicides ...... 53 Cobalt ...... 51 Heroin ...... 34 Cocaine ...... 33 Hydrogen sulphide ...... 46 Colchicine ...... 33 Hydroxychloroquine ...... 30 Contrast media ...... 43 Hypoglycaemic drugs ...... 34 Corrosives ...... 43 Idarucizumab ...... 25 Corticosteroids ...... 33 Ifosfamide ...... 32 Cosmetics ...... 43 Iminothiazolidinones ...... 46 Crotalinae ...... 57 Immunoglobulins ...... 34 Curcuma longa ...... 55 Immunomodulatory drugs ...... 34 Curcumin ...... 26 Inhalation toxicity ...... 17 Cyanoacrylate ...... 44 Insecticides (general) ...... 53 Cyclophosphamide ...... 31 Insulin ...... 26 Cytotoxic drugs ...... 33 Irinotecan ...... 32 Dabigatran ...... 30 Isocyanates ...... 46 Dacarbazine ...... 31 Ivermectin ...... 34 Datura spp...... 55 Ixodes holocyclus ...... 56 Deadly nightshade ...... 55 Jequirity ...... 55 Dermal toxicity...... 14 Ketoprofen ...... 36 Developmental toxicology ...... 15 Kinetics ...... 18

59

Kratom ...... 34, 56 Plants, general ...... 55 L-cysteine ...... 26 PM10 ...... 40 Lead...... 51 Poison information centres ...... 23 Lindane ...... 54 Poisons information ...... 23 Lipid emulsion therapy ...... 25 Pollution ...... 40 Lithium ...... 34, 51 Polybrominated diphenyl ethers ...... 48 Loperamide ...... 34 Polycyclic aromatic hydrocarbons ...... 48 Loxapine ...... 26 Polygonum multiflorum ...... 56 LSD ...... 34 Polymorphisms ...... 23 Management, general ...... 24 Polymyxin B ...... 29 Marijuana ...... 32 Polyvinyl acetate ...... 48 MB327...... 25 Potassium ...... 38 MDMA ...... 29 Pregabalin ...... 30 Mechanisms ...... 18 Progesterone ...... 27 Medication errors ...... 18 Propofol ...... 29 Mercury ...... 51 Proteasome inhibitors ...... 38 Metabolism ...... 18 Prothipendyl ...... 39 Metaldehyde ...... 53 Pyrethroid insecticides, general ...... 54 Metallothionein ...... 26 Quercetin ...... 27 Metals, general ...... 50 Radiation ...... 48 Metformin ...... 34 Radon ...... 48 Methadone ...... 38 Reactive skin decontamination lotion ...... 27 Methadone maintenance therapy ...... 27 Reprotoxicity ...... 23 Methanol ...... 47 Ricin ...... 54 Metoclopramide ...... 27 Ricinus communis ...... 56 Microorganisms ...... 56 Risk assessment ...... 24 Mineral fibres ...... 47 Rodenticides ...... 54 Mitragyna speciosa...... 56 Rosiglitazone ...... 39 Monoclonal antibodies ...... 35 Rutin ...... 27 MT-45 ...... 38 Sarin ...... 55 Mustard gas ...... 55 Scorpions ...... 56 Mycotoxins ...... 47 Sedatives ...... 39 Naloxone ...... 25 Sevoflurane ...... 29 Naltrexone ...... 27 Shiga toxins ...... 48 Nanoparticles ...... 27, 47 Silicates ...... 49 Nedaplatin ...... 32 Siloxanes ...... 49 Neonicotinoids ...... 53 Silver ...... 52 Nephrotoxicity ...... 18 Silymarin ...... 26 Nerve agents ...... 55 Snake bites ...... 57 Neurotoxicity ...... 19 Solvents ...... 49 Nickel ...... 52 Spanish broom ...... 56 Nicotine ...... 35 Spartium junceum ...... 56 Nitric oxide ...... 47 Spiders ...... 57 Nitromethane...... 47 SSRIs and SNRIs ...... 39 Nonylphenol ...... 47 Star fruit ...... 55 Novel psychoactive substances ...... 35 Statins ...... 39 NSAIDs ...... 36 Substance abuse ...... 39 Occupational toxicology ...... 20 Suicide ...... 24 Ocular toxicity ...... 21 Synthetic cannabinoids ...... 35 Olaparib ...... 32 Synthetic cathinones ...... 36 Oleracein E ...... 27 Synthetic opioids ...... 36 Opioid maintenance therapy ...... 27 Talc ...... 49 Opioids ...... 36 Temozolomide ...... 32 Opium ...... 38 Terpenes ...... 49 Organochlorine pesticides, general ...... 53 Tetramethylenedisulfotetramine ...... 54 Organophosphorus insecticides, general ...... 54 Thallium...... 52, 54 Ortho-fluorofentanyl ...... 38 Thiacloprid ...... 53 Oxaliplatin ...... 32 Tobacco ...... 49 Oxycodone ...... 38 Toluene ...... 49 Ozone ...... 47 Toluene diisocyanate ...... 50 Paediatric toxicology ...... 21 Topiramate ...... 30 Paracetamol ...... 38 Toxicology, general ...... 11 Paralytic shellfish poisoning ...... 56 Tramadol ...... 38 Pequi ...... 55 Treosulfan...... 32 Perfluorooctanesulfonic acid ...... 48 Trichloroethylene ...... 50 Pesticides and cancer ...... 52 True vipers...... 57 Pesticides, general ...... 52 Tuber fleeceflower ...... 56 Phencyclidine ...... 38 Turmeric ...... 55 Phenethylamines ...... 35 U-47700...... 38 Phosphorus ...... 48 Uranium ...... 52 Phthalates ...... 48 Uridine triacetate ...... 27 Pit vipers ...... 57 Valproate ...... 30

60

Vanadium ...... 52 VX ...... 55 Vermiculite ...... 50 Zinc ...... 52 Viperinae ...... 57 Zolpidem ...... 39 Vitamins ...... 40

Current Awareness in Clinical Toxicology is produced monthly for the American Academy of Clinical Toxicology by the Birmingham Unit of the UK National Poisons Information Service, with contributions from the Cardiff, Edinburgh, and Newcastle Units.

The NPIS is commissioned by Public Health England