Booklet 4 Stimulants Preface
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International Collaborative Exercises (Ice)
INTERNATIONAL QUALITY ASSURANCE PROGRAMME (IQAP) INTERNATIONAL COLLABORATIVE EXERCISES (ICE) Summary Report BIOLOGICAL SPECIMENS 2013/2 INTERNATIONAL QUALITY ASSURANCE PROGRAMME (IQAP) INTERNATIONAL COLLABORATIVE EXERCISES (ICE) Table of contents Introduction Page 3 Comments from the International Panel of Forensic Experts Page 3 Codes and Abbreviations Page 4 Sample 1 Analysis Page 5 Identified substances Page 5 Statement of findings Page 6 Identification methods Page 10 Summary Page 12 Z-Scores Page 13 Sample 2 Analysis Page 15 Identified substances Page 15 Statement of findings Page 16 Identification methods Page 20 Summary Page 22 Z-Scores Page 23 Sample 3 Analysis Page 25 Identified substances Page 25 Statement of findings Page 27 Identification methods Page 31 Summary Page 33 Z-Scores Page 34 Sample 4 Analysis Page 36 Identified substances Page 36 Statement of findings Page 38 Identification methods Page 42 Summary Page 44 Test Samples Information Samples Comments on samples Sample 1 To prepare BS-1, urine was spiked with 4-Bromo-2,5-dimethoxyphenethylamine (2C-B) (1590 ng base/ml), as an ethanolic solution. The spiked urine was dispensed in 50ml aliquots and lyophilised Sample 2 To prepare BS-2, urine was spiked with Gammahydroxybutyrate (GHB) (14360 ng base/ml), as an aqueous solution. The spiked urine was dispensed in 50ml aliquots and lyophilised Sample 3 To prepare BS-3, urine was spiked with Amfetamine sulphate (1570ng/ml, 1150 ng base/ml) and Metamfetamine hydrochloride (4290 ng/ml, 3450 ng base/ml) as aqueous solutions. The spiked urine was dispensed in 50ml aliquots and lyophilised Sample 4 BS-4 was a blank test sample containing no substances in the ICE menu Samples Substances Concentrations Comments on substances Sample 1 4-Bromo-2,5-dimethoxyphenethylamine (2C- 1590 ng/ml B) Sample 2 gamma-Hydroxybutyric acid (GHB) 14360 ng/ml Sample 3 Metamfetamine 3450 ng/ml Amfetamine 1150 ng/ml Sample 4 [blank sample] This report contains the data received from laboratories participating in the current exercise. -
Octodrine: New Questions and Challenges in Sport Supplements
brain sciences Article Octodrine: New Questions and Challenges in Sport Supplements Valeria Catalani 1,2, Mariya Prilutskaya 3 ID , Ahmed Al-Imam 4 ID , Shanna Marrinan 5, Yasmine Elgharably 6, Mire Zloh 2 ID , Giovanni Martinotti 7 ID , Robert Chilcott 1,2 and Ornella Corazza 2,* ID 1 Research Centre for Topical Drug Delivery and Toxicology, University of Hertfordshire, Herts SP9 11FA, UK; [email protected] (V.C.); [email protected] (R.C.) 2 Department of Pharmacy, Pharmacology and Clinical Science, University of Hertfordshire, Herts AL10 9AB, UK; [email protected] 3 Semey State Medical University, Republican Scientific and Practical Center of Mental Health, Pavlodar 140002, Kazakhstan; [email protected] 4 Faculty of Medicine, University of Baghdad, Baghdad 10071, Iraq; [email protected] 5 Parliamentary Office of Science and Technology, Houses of Parliament, London SW1A 0AA, UK; [email protected] 6 Navy General Hospital, Cardiovascular department, Alexandria 21513, Egypt; [email protected] 7 Department of Neuroscience, Imaging and Clinical Sciences, “G.d’Annunzio” University, 66100 Chieti, Italy; [email protected] * Correspondence: [email protected] Received: 31 January 2018; Accepted: 17 February 2018; Published: 20 February 2018 Abstract: Background: Octodrine is the trade name for Dimethylhexylamine (DMHA), a central nervous stimulant that increases the uptake of dopamine and noradrenaline. Originally developed as a nasal decongestant in the 1950’s, it has recently been re-introduced on the market as a pre-workout and ‘fat-burner’ product but its use remains unregulated. Our work provides the first observational cross-sectional analytic study on Octodrine as a new drug trend and its associated harms after a gap spanning seven decades. -
Recommended Methods for the Identification and Analysis of Synthetic Cathinones in Seized Materialsd
Recommended methods for the Identification and Analysis of Synthetic Cathinones in Seized Materials (Revised and updated) MANUAL FOR USE BY NATIONAL DRUG ANALYSIS LABORATORIES Photo credits:UNODC Photo Library; UNODC/Ioulia Kondratovitch; Alessandro Scotti. Laboratory and Scientific Section UNITED NATIONS OFFICE ON DRUGS AND CRIME Vienna Recommended Methods for the Identification and Analysis of Synthetic Cathinones in Seized Materials (Revised and updated) MANUAL FOR USE BY NATIONAL DRUG ANALYSIS LABORATORIES UNITED NATIONS Vienna, 2020 Note Operating and experimental conditions are reproduced from the original reference materials, including unpublished methods, validated and used in selected national laboratories as per the list of references. A number of alternative conditions and substitution of named commercial products may provide comparable results in many cases. However, any modification has to be validated before it is integrated into laboratory routines. ST/NAR/49/REV.1 Original language: English © United Nations, March 2020. All rights reserved, worldwide. The designations employed and the presentation of material in this publication do not imply the expression of any opinion whatsoever on the part of the Secretariat of the United Nations concerning the legal status of any country, territory, city or area, or of its authorities, or concerning the delimitation of its frontiers or boundaries. Mention of names of firms and commercial products does not imply the endorse- ment of the United Nations. This publication has not been formally edited. Publishing production: English, Publishing and Library Section, United Nations Office at Vienna. Acknowledgements The Laboratory and Scientific Section of the UNODC (LSS, headed by Dr. Justice Tettey) wishes to express its appreciation and thanks to Dr. -
Slang Terms and Code Words: a Reference for Law Enforcement
UNCLASSIFIED Slang Terms and Code Words: A Reference for Law DEA Enforcement Personnel Intelligence DEA-HOU-DIR-022-18 July 2018 ReportBrief 1 UNCLASSIFIED UNCLASSIFIED DEA Intelligence Report Executive Summary This Drug Enforcement Administration (DEA) Intelligence Report contains new and updated information on slang terms and code words from a variety of law enforcement and open sources, and serves as an updated version to the product entitled “Drug Slang Code Words” published by the DEA in May 2017. It is designed as a ready reference for law enforcement personnel who are confronted with hundreds of slang terms and code words used to identify a wide variety of controlled substances, designer drugs, synthetic compounds, measurements, locations, weapons, and other miscellaneous terms relevant to the drug trade. Although every effort was made to ensure the accuracy and completeness of the information presented, due to the dynamics of the ever-changing drug scene, subsequent additions, deletions, and corrections are inevitable. Future addendums and updates to this report will attempt to capture changed terminology to the furthest extent possible. This compendium of slang terms and code words is alphabetically ordered, with new additions presented in italic text, and identifies drugs and drug categories in English and foreign language derivations. Drug Slang Terms and Code Wordsa Acetaminophen and Oxycodone Combination (Percocet®) 512s; Bananas; Blue; Blue Dynamite; Blueberries; Buttons; Ercs; Greenies; Hillbilly Heroin; Kickers; M-30s; -
(12) Patent Application Publication (10) Pub. No.: US 2006/0110428A1 De Juan Et Al
US 200601 10428A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2006/0110428A1 de Juan et al. (43) Pub. Date: May 25, 2006 (54) METHODS AND DEVICES FOR THE Publication Classification TREATMENT OF OCULAR CONDITIONS (51) Int. Cl. (76) Inventors: Eugene de Juan, LaCanada, CA (US); A6F 2/00 (2006.01) Signe E. Varner, Los Angeles, CA (52) U.S. Cl. .............................................................. 424/427 (US); Laurie R. Lawin, New Brighton, MN (US) (57) ABSTRACT Correspondence Address: Featured is a method for instilling one or more bioactive SCOTT PRIBNOW agents into ocular tissue within an eye of a patient for the Kagan Binder, PLLC treatment of an ocular condition, the method comprising Suite 200 concurrently using at least two of the following bioactive 221 Main Street North agent delivery methods (A)-(C): Stillwater, MN 55082 (US) (A) implanting a Sustained release delivery device com (21) Appl. No.: 11/175,850 prising one or more bioactive agents in a posterior region of the eye so that it delivers the one or more (22) Filed: Jul. 5, 2005 bioactive agents into the vitreous humor of the eye; (B) instilling (e.g., injecting or implanting) one or more Related U.S. Application Data bioactive agents Subretinally; and (60) Provisional application No. 60/585,236, filed on Jul. (C) instilling (e.g., injecting or delivering by ocular ion 2, 2004. Provisional application No. 60/669,701, filed tophoresis) one or more bioactive agents into the Vit on Apr. 8, 2005. reous humor of the eye. Patent Application Publication May 25, 2006 Sheet 1 of 22 US 2006/0110428A1 R 2 2 C.6 Fig. -
Smokable Cocaine Markets in Latin America and the Caribbean a Call for a Sustainable Policy Response
Smokable cocaine markets in Latin America and the Caribbean A call for a sustainable policy response ideas into movement AUTHORS: Ernesto Cortés and Pien Metaal EDITOR: Anthony Henman DESIGN: Guido Jelsma - www.guidojelsma.nl COVER PHOTO: Man smoking crack pipe Colombia, L. Niño. ACKNOWLEDGEMENTS: This publication was made possible through the financial support of the Open Society Foundation (OSF) and the Global Partnership on Drug Policies and Development (GPDPD). GPDPD is a project implemented by the Deutsche Gesellschaft für Internationale Zusammenarbeit (GIZ) GmbH on behalf of the Federal Ministry for Economic Cooperation and Development (BMZ) and under the political patronage of the Federal Government’s Drug Commissioner. The contents of this report are the sole responsibility of TNI and can under no circumstances be regarded as reflecting the position of the donors. PUBLICATION DETAILS: Contents of the report may be quoted or reproduced for non-commercial purposes, provided that the source of information is properly cited. TRANSNATIONAL INSTITUTE (TNI) De Wittenstraat 25, 1052 AK Amsterdam, The Netherlands Tel: +31-20-6626608, Fax: +31-20-6757176 E-mail: [email protected] www.tni.org/drugs @DrugLawReform Drugsanddemocracy Amsterdam, December 2019 2 | Smokable cocaine markets in Latin America and the Caribbean transnationalinstitute Contents Introduction 4 Methodological approach 6 The Substance(s) 8 Smokable cocaine in Cochabamba (Bolivia) in the early 1990s 9 Users 14 Impact on health 17 The Market 21 Harm Reduction experiences 25 Conclusions and Discussion 28 Policy Recommendations 29 Good Practices: examples from Brazil 30 Bibiography and references 32 International smokable cocaines working group 33 Endnotes 34 transnationalinstitute Smokable cocaine markets in Latin America and the Caribbean | 3 Introduction regions. -
Interactions Between Ethanol and Cocaine, Amphetamine, Or MDMA in the Rat: Thermoregulatory and Locomotor Effects
Psychopharmacology DOI 10.1007/s00213-007-1007-5 ORIGINAL INVESTIGATION Interactions between ethanol and cocaine, amphetamine, or MDMA in the rat: thermoregulatory and locomotor effects Sami Ben Hamida & Erin Plute & Brigitte Cosquer & Christian Kelche & Byron C. Jones & Jean-Christophe Cassel Received: 22 May 2007 /Accepted: 29 October 2007 # Springer-Verlag 2007 Abstract duced by EtOH alone. Conversely, EtOH attenuated Rationale (±)-3,4-methylenedioxymethamphetamine MDMA-related hyperthermia, an effect increasing across (MDMA, ecstasy) is often taken recreationally with ethanol treatment days. These results demonstrate that the interac- (EtOH). In rats, EtOH may potentiate MDMA-induced tion between MDMA and EtOH may be different from the hyperactivity, but attenuate hyperthermia. interaction between EtOH and AMPH or COCA. Objective Experiment 1 compared the interactions between Conclusion Because of potential health-related consequen- EtOH (1.5 g/kg) and MDMA (6.6 mg/kg) with EtOH + ces of such polydrug misuse, it is worth identifying the cocaine (COCA; 10 mg/kg) and EtOH + amphetamine mechanisms underlying these interactions, especially be- (AMPH; 1 mg/kg) on locomotor activity and thermoregu- tween EtOH and MDMA. Given the different affinity lation. Experiment 2 used a weaker dose of MDMA profiles of the three drugs for serotonin, dopamine, and (3.3 mg/kg) and larger doses of COCA (20 mg/kg) and norepinephrine transporters, our results appear compatible AMPH (2 mg/kg). with the possibility of an important role of serotonin in at Materials and methods Drug treatments were administered least the EtOH-induced potentiation of MDMA-induced on four occasions (2, 5, and 2 days apart, respectively; hyperlocomotion. -
(19) United States (12) Patent Application Publication (10) Pub
US 20130289061A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2013/0289061 A1 Bhide et al. (43) Pub. Date: Oct. 31, 2013 (54) METHODS AND COMPOSITIONS TO Publication Classi?cation PREVENT ADDICTION (51) Int. Cl. (71) Applicant: The General Hospital Corporation, A61K 31/485 (2006-01) Boston’ MA (Us) A61K 31/4458 (2006.01) (52) U.S. Cl. (72) Inventors: Pradeep G. Bhide; Peabody, MA (US); CPC """"" " A61K31/485 (201301); ‘4161223011? Jmm‘“ Zhu’ Ansm’ MA. (Us); USPC ......... .. 514/282; 514/317; 514/654; 514/618; Thomas J. Spencer; Carhsle; MA (US); 514/279 Joseph Biederman; Brookline; MA (Us) (57) ABSTRACT Disclosed herein is a method of reducing or preventing the development of aversion to a CNS stimulant in a subject (21) App1_ NO_; 13/924,815 comprising; administering a therapeutic amount of the neu rological stimulant and administering an antagonist of the kappa opioid receptor; to thereby reduce or prevent the devel - . opment of aversion to the CNS stimulant in the subject. Also (22) Flled' Jun‘ 24’ 2013 disclosed is a method of reducing or preventing the develop ment of addiction to a CNS stimulant in a subj ect; comprising; _ _ administering the CNS stimulant and administering a mu Related U‘s‘ Apphcatlon Data opioid receptor antagonist to thereby reduce or prevent the (63) Continuation of application NO 13/389,959, ?led on development of addiction to the CNS stimulant in the subject. Apt 27’ 2012’ ?led as application NO_ PCT/US2010/ Also disclosed are pharmaceutical compositions comprising 045486 on Aug' 13 2010' a central nervous system stimulant and an opioid receptor ’ antagonist. -
DOCTORAL THESIS Effects of Glucocorticoid Overload on Central
DOCTORAL THESIS Effects of glucocorticoid overload on central regulatory systems involved in responses to stress – preclinical investigations into putative molecular targets in neuroimaging of stress-related mood disorders Ahmad, Rabia Award date: 2013 General rights Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights. • Users may download and print one copy of any publication from the public portal for the purpose of private study or research. • You may not further distribute the material or use it for any profit-making activity or commercial gain • You may freely distribute the URL identifying the publication in the public portal ? Take down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. Download date: 07. Oct. 2021 “Effects of glucocorticoid overload on central regulatory systems involved in responses to stress – preclinical investigations into putative molecular targets in neuroimaging of stress-related mood disorders” By Rabia Ahmad, BSc (Hons). A thesis submitted in partial fulfilment of the requirements for the degree of PhD Department of Life Sciences University of Roehampton 2013 Abstract Irregularities of the Hypothalamic Pituitary Adrenal (HPA) axis are implicated in stress-related mood disorders. The ensuing long-term elevations in circulating glucocorticoids are associated with neurobiological changes seen in depression. This thesis aims to identify some of the brain mechanisms by which exposure to chronic stress may lead to depression using a preclinical experimental approach. -
UFC PROHIBITED LIST Effective June 1, 2021 the UFC PROHIBITED LIST
UFC PROHIBITED LIST Effective June 1, 2021 THE UFC PROHIBITED LIST UFC PROHIBITED LIST Effective June 1, 2021 PART 1. Except as provided otherwise in PART 2 below, the UFC Prohibited List shall incorporate the most current Prohibited List published by WADA, as well as any WADA Technical Documents establishing decision limits or reporting levels, and, unless otherwise modified by the UFC Prohibited List or the UFC Anti-Doping Policy, Prohibited Substances, Prohibited Methods, Specified or Non-Specified Substances and Specified or Non-Specified Methods shall be as identified as such on the WADA Prohibited List or WADA Technical Documents. PART 2. Notwithstanding the WADA Prohibited List and any otherwise applicable WADA Technical Documents, the following modifications shall be in full force and effect: 1. Decision Concentration Levels. Adverse Analytical Findings reported at a concentration below the following Decision Concentration Levels shall be managed by USADA as Atypical Findings. • Cannabinoids: natural or synthetic delta-9-tetrahydrocannabinol (THC) or Cannabimimetics (e.g., “Spice,” JWH-018, JWH-073, HU-210): any level • Clomiphene: 0.1 ng/mL1 • Dehydrochloromethyltestosterone (DHCMT) long-term metabolite (M3): 0.1 ng/mL • Selective Androgen Receptor Modulators (SARMs): 0.1 ng/mL2 • GW-1516 (GW-501516) metabolites: 0.1 ng/mL • Epitrenbolone (Trenbolone metabolite): 0.2 ng/mL 2. SARMs/GW-1516: Adverse Analytical Findings reported at a concentration at or above the applicable Decision Concentration Level but under 1 ng/mL shall be managed by USADA as Specified Substances. 3. Higenamine: Higenamine shall be a Prohibited Substance under the UFC Anti-Doping Policy only In-Competition (and not Out-of- Competition). -
WHO Expert Committee on Drug Dependence Thirty-Eighth Report
WHO Expert Committee on Drug Dependence Thirty-eighth report This report contains the views of an international group of experts, and does not necessarily represent the decisions or the stated policy of the World Health Organization iii Contents WHO Expert Committee on Drug Dependence vi Abbreviations ix Introduction 1 1. Briefings from International Organizations on their work on the public health element of the world drug problem 4 1.1 Update from the International Narcotics Control Board 4 1.2 Update from the United Nations Office on Drugs and Crime 5 1.3 Update from the Department of Essential Medicines and Health Products, WHO 7 1.4 Update from the Department of Mental Health and Substance Abuse, WHO 9 1.5 Update from the Department of HIV/AIDS, WHO 9 2. Principles for prioritizing and assessing substances as part of ECDD work 11 3. Update from the 1st Informal Working Group of the ECDD 12 4. Follow-up on recommendations made by the ECDD at its thirty-seventh meeting 13 5. Critical review of psychoactive substances 14 5.1 U- 47700 15 5.2 Butyrfentanyl (Butyrylfentanyl) 17 5.3 4-Methylethcathinone (4-MEC) 18 5.4 3-Methylmethcathinone (3-methyl-N-methylcathinone; 3-MMC) 21 iv 5.5 Ethylone (3,4-metheylenedioxy-N-ethylcathinone; bk-MDEA; MEDEC) 23 5.6 Pentedrone (α-Methylaminovalerophenone) 24 5.7 Ethylphenidate (EPH) 26 5.8 Methiopropamine (MPA) 28 5.9 MDMB-CHMICA 30 5.10 5F-APINACA (5F-AKB-48) 32 5.11 JWH-073 34 5.12 XLR-11 36 6. Updates 37 6.1 Cannabis and cannabis resin 37 7. -
A User's Guide to Methamphetamine
A USER’S GUIDE TO METHAMPHETAMINE A self-help guide to reduce harm for people who use methamphetamine 1st Edition, March 2017 Acknowledgements This booklet was adapted from an original publication created by The National Drug and Alcohol Research Centre, University of New South Wales, Sydney, Australia. This information does not constitute medical advice. Please seek the immediate help of a qualified medical practitioner about any personal health concerns. This booklet is being distributed for information purposes only. In the current state of crisis related to crystal methamphetamine, this booklet is intended as a guide to reduce harm for people who use methamphetamine. It lists the most common features of methamphetamine use, ways to reduce harm associated with the use of meth, and strategies for cutting down and quitting. The best way to avoid problems with drugs is to not use them. We are grateful for the contributions of the Integrated Drug Strategies in Waterloo Region and Guelph Wellington, in particular the leadership of Adrienne Crowder and Lindsay Sprague. Don Roth, Kerry Manthenga, Shirley Hilton, and our community review team provided great support and helpful edits. Marcey Gray provided exemplary skill on the design, images and editing, with final expert assistance from Arkay Design and Print. We are thankful for the financial support to print copies from the Waterloo-Wellington Human Services and Justice Coordinating Committee. For more information please contact: Wellington Guelph Drug Strategy www.wgdrugstrategy.ca Waterloo Region Integrated Drugs Strategy www.waterlooregiondrugstrategy.ca Circulated with the support of: WaterlooRegion Integrated Drugs Strategy WaterlooRegion Integrated Drugs Strategy The best way to avoid problems with drugs is to not use them.