Supplementary Table S1: Full List of Environmental Chemical Hazards on Reproduction

Total Page:16

File Type:pdf, Size:1020Kb

Supplementary Table S1: Full List of Environmental Chemical Hazards on Reproduction Supplementary Table S1: Full list of environmental chemical hazards on reproduction. Category CAS Number Name of the reproductive risk factor 1 630-08-0 carbon monoxide 1 25808-74-6 lead hexafluorosilicate slimes and sludges, copper electrolyte refining, 1 94551-87-8 decopperised 1 68130-19-8 silicic acid, lead nickel salt lead compounds with the exception of those specified 1 elsewhere in the CLP regulation 1 lead alkyls 1 13424-46-9 lead diazide ,lead azide 1 7758-97-6 lead chromate 1 301-04-2, 6080-56-4 lead di(acetate) 1 7446-27-7 trilead bis(orthophosphate) 1 1335-32-6 lead acetate, basic 1 17570-76-2 lead(II) methanesulphonate 1 1344-37-2 lead sulfochromate yellow 1 12656-85-8 lead chromate molybdate sulfate red 1 7784-40-9 lead hydrogen arsenate 1 7439-92-1 lead 1 96-12-8 1,2-dibromo-3-chloropropane 1 102-06-7 1,3-diphenylguanidine 1 629-14-1 1,2-diethoxyethane 1 abacavir 1 68049-83-2 azafenidin 1 15245-44-0 lead styphnate 1 13517-20-9, 15120-21-5 perboric acid (H3BO2(O2)), monosodium salt, trihydrate 10332-33-9, 11138-47-9, perboric acid, sodium salt, monohydrate, perboric acid, 1 12040-72-1, 37244-98-7 sodium salt disodium octaborate tetrahydrate, disodium octaborate 1 12008-41-2, 12280-03-4 anhydrous 1 17804-35-2 benomyl 1 485-31-4 binapacryl 1 56073-10-0 brodifacoum 1 27366-72-9 (dimethylamino)thioacetamide hydrochloride 1 28772-56-7 bromadiolone [6,9-dihydro-9-[[2-hydroxy-1- 1 84245-12-5 (hydroxymethyl)ethoxy]methyl]-6-oxo-1H-purin-2- yl]acetamide 1 74-83-9 bromomethane 1 75113-37-0 dibutyltin hydrogen borate 1 10043-35-3 boric acid 1 1303-86-2 diboron trioxide 1 12267-73-1 tetraboron disodium heptaoxide, hydrate 1 13840-56-7 orthoboric acid, sodium salt 1303-96-4, 1330-43-4, 1 disodium tetraborate decahydrate 12179-04-3 7632-04-4, 10332-33-9, 1 sodium peroxometaborate 10486-00-7 1 106-94-5 1-bromopropane 1 7778-50-9 potassium dichromate 1 7789-09-5 ammonium dichromate 1 7789-12-0, 10588-01-9 sodium dichromate 1 7775-11-3 sodium chromate 1 7646-79-9, 7791-13-1 cobalt dichloride 1 10026-24-1, 10124-43-3 cobalt sulfate 1 71-48-7, 6147-53-1 cobalt di(acetate) 1 10026-22-9, 10141-05-6 cobalt dinitrate 1 513-79-1 cobalt carbonate 1 13463-39-3 tetracarbonylnickel 1 12054-48-7 nickel dihydroxide 1 11113-74-9 nickel hydroxide 7786-81-4, 10101-97-0, 1 nickel sulfate 10101-98-1 1 12607-70-4 [carbonato(2-)]tetrahydroxytrinickel 1 65405-96-1 [µ-[carbonato(2-)-O:O’]] dihydroxy trinickel 1 16337-84-1 carbonic acid, nickel salt 1 3333-67-3 nickel carbonate 1 7718-54-9, 7791-20-0 nickel dichloride 1 14216-75-2 nitric acid, nickel salt 1 13138-45-9, 13478-00-7 nickel dinitrate slimes and sludges, copper electrolytic refining, 1 92129-57-2 decopperised, nickel sulfate 1 13637-71-3 nickel diperchlorate 1 15699-18-0 diammonium nickel bis(sulfate) 1 13842-46-1 nickel dipotassium bis(sulfate) 1 13770-89-3 nickel bis(sulfamidate) 1 14708-14-6 nickel bis(tetrafluoroborate) 1 68134-59-8 formic acid, copper nickel salt 1 15843-02-4 formic acid, nickel salt 1 3349-06-2 nickel diformate 1 14998-37-9 nickel acetate 1 373-02-4, 6018-89-9 nickel di(acetate) 1 553-71-9 nickel dibenzoate 1 3906-55-6 nickel bis(4-cyclohexylbutyrate) 1 2223-95-2 nickel(II) stearate 1 16039-61-5 nickel dilactate 1 4995-91-9 nickel(II) octanoate 1 13462-88-9 nickel dibromide 1 13462-90-3 nickel diiodide 1 10028-18-9 nickel difluoride 1 11132-10-8 nickel potassium fluoride 1 26043-11-8 nickel hexafluorosilicate 1 15060-62-5 nickel selenate 1 13689-92-4 nickel dithiocyanate 1 15586-38-6 nickel dichromate 1 67952-43-6 nickel dichlorate 1 71720-48-4 ethyl hydrogen sulfate, nickel(II) salt 1 14550-87-9 nickel dibromate 1 93983-68-7 dimethylhexanoic acid nickel salt 1 84852-36-8 (isodecanoato-O)(isononanoato-O)nickel 1 84852-35-7 (isooctanoato-O)(neodecanoato-O)nickel 1 84852-37-9 nickel bis(isononanoate) 1 84852-39-1 (2-ethylhexanoato-O)(isodecanoato-O)nickel 1 13654-40-5 nickel(II) palmitate 1 52625-25-9 nickel 3,5-bis(tert-butyl)-4-hydroxybenzoate (1:2) 1 93920-10-6 nickel(II) neononanoate 1 71957-07-8 bis(D-gluconato-O1,O2)nickel 1 84776-45-4 fatty acids, C8-18 and C18-unsatd., nickel salts 1 93920-09-3 nickel(II) neoundecanoate 1 3349-08-4 nickel(II) propionate 1 7580-31-6 2-ethylhexanoic acid, nickel salt 1 39819-65-3 nickel bis(benzenesulfonate) 1 18283-82-4 citric acid, ammonium nickel salt 1 85508-44-7 nickel(II) neodecanoate 1 85508-43-6 nickel(II) isodecanoate 1 85551-28-6 (isononanoato-O)(neodecanoato-O)nickel 1 29317-63-3 nickel(II) isooctanoate 1 85508-46-9 (isononanoato-O)(isooctanoato-O)nickel 1 85508-45-8 (2-ethylhexanoato-O)(isononanoato-O)nickel 1 4454-16-4 nickel bis(2-ethylhexanoate) 1 85166-19-4 (isodecanoato-O)(isooctanoato-O)nickel 1 91697-41-5 fatty acids, C6-19-branched, nickel salts 1 16083-14-0 nickel(II) trifluoroacetate 1 22605-92-1 citric acid, nickel salt 1 85135-77-9 (2-ethylhexanoato-O)(neodecanoato-O)nickel 1 51818-56-5 neodecanoic acid, nickel salt 1 18721-51-2 nickel(II) hydrogen citrate 1 27637-46-3 nickel isooctanoate 1 72319-19-8 2,7-naphthalenedisulfonic acid, nickel(II) salt 1 1303-00-0 gallium arsenide 1 7790-79-6 cadmium fluoride 1 10108-64-2, 35658-65-2 cadmium chloride 7790-84-3, 10124-36-4, 1 cadmium sulphate 31119-53-6 tributyltin compounds, with the exception of those 1 specified elsewhere in this annex 1 683-18-1 dibutyltin dichloride 2-ethylhexyl 10-ethyl-4,4-dioctyl-7-oxo-8-oxa-3,5-dithia-4- 1 15571-58-1 stannatetradecanoate 1 77-58-7 dibutyltin dilaurate 1 7439-97-6 Mercury and mercury compounds 1 50-32-8, 63466-71-7 benzo[a]pyrene 1 111-41-1 2-(2-aminoethylamino)ethanol 1 96-18-4 1,2,3-trichloropropane 1 106-91-2 2,3-epoxypropyl methacrylate 1 109-86-4, 109-87-5 2-methoxyethanol 1 110-80-5 2-ethoxyethanol 1 110-71-4 1,2-dimethoxyethane 1 556-52-5 2,3-epoxypropan-1-ol 1 78-93-3 2-butanone 1 1589-47-5 2-methoxypropanol 1 111-96-6 bis(2-methoxyethyl) ether 1 75-26-3 2-bromopropane 1 112-49-2 1,2-bis(2-methoxyethoxy)ethane 2-methyl-1-(4-methylthiophenyl)-2-morpholinopropan-1- 1 71868-10-5 one 1 6807-17-6 4,4-isobutylethylidenediphenol 1 80-05-7 bisphenol A 1 ado-trastuzumab emtansine 1 79-06-1, 122775-19-3 acrylamide 1 75-15-0 carbon disulphide 1 67-66-3 chloroform 1 32536-52-0 diphenylether; octabromo derivate 1 96-45-7 ethylene thiourea 1 10605-21-7 carbendazim 1 127-19-5 dimethylacetamide 1 624-83-9 methyl isocyanate 1,2-benzenedicarboxylic acid, dihexyl ester, branched and 1 68515-50-4 linear 2-[2-hydroxy-3-(2-chlorophenyl)carbamoyl-1-naphthylazo]- 1 151798-26-4 7-[2-hydroxy-3-(3-methylphenyl)carbamoyl-1- naphthylazo]fluoren-9-one 2-butyryl-3-hydroxy-5-thiocyclohexan-3-yl-cyclohex-2-en-1- 1 94723-86-1 one 1 110-49-6 2-methoxyethyl acetate 1 111-15-9 2-ethoxyethyl acetate 1 16118-49-3 carbetamide 1 2687-91-4 N-ethyl-2-pyrrolidone 1 3691-35-8 chlorophacinone 2-ethylhexyl[[[3,5-bis(1,1-dimethylethyl)-4- 1 80387-97-9 hydroxyphenyl]methyl]thio]acetate 1 68515-42-4 1,2-benzenedicarboxylic acid 1 70657-70-4 2-methoxypropyl acetate 1 5836-29-3 coumatetralyl 1 66-81-9 cycloheximide 1 625-45-6 methoxyacetic acid 1,2-benzenedicarboxylic acid, dipentylester, branched and 1 84777-06-0 linear 1 85-68-7 benzyl butyl phtalate 1 94361-06-5 cyproconazole 1 56073-07-5 difenacoum 1 117-81-7 bis(2-ethylhexyl) phthalate 1 117-82-8 bis(2-methoxyethyl) phthalate 1 84-74-2, 93952-11-5 dibutyl phthalate 1 84-61-7 dicyclohexyl phthalate 1 84-75-3 dihexyl phthalate 1 84-69-5 diisobutyl phthalate 1 7425-14-1 2-ethylhexyl-2-ethylhexanoate 1 605-50-5 diisopentylphthalate 1 3108-42-7 ammonium nonadecafluorodecanoate 1 29081-56-9 ammonium perfluorooctane sulfonate 1 3825-26-1 ammoniumpentadeca- fluorooctanoate 1 70225-14-8 diethanolamine perfluorooctane sulfonate 1 29457-72-5 lithium perfluorooctane sulfonate 1 143860-04-2 3-ethyl-2-methyl-2-(3-methylbutyl)-1,3-oxazolidine 1 84-74-2 Di-n-butyl phthalate (DBP) 1 335-76-2 nonadecafluorodecanoic acid 1 375-95-1 perfluorononan-1-oic acid 1 98-73-7 4-tert-butylbenzoic acid 1 104653-34-1 difethialone 1 39300-45-3 dinocap 1 4149-60-4 perfluorononan-1-oic acid ammonium salts 1 21049-39-8 perfluorononan-1-oic acid sodium salts 1 1763-23-1 perfluorooctane sulfonic acid 1 131-18-0 di-n-pentyl phthalate 1 335-67-1 perfluorooctanoic acid 1 2795-39-3 potassium perfluorooctanesulfonate 1 3830-45-3 sodium nonadecafluorodecanoate 1 98-95-3 nitrobenzene 1 88-85-7 dinoseb 1 1420-07-1 dinoterb 1 106325-08-0, 133855-98-8 epoxiconazole 1 37894-46-5 etacelasil 1 90035-08-8 flocoumafen 1 69806-50-4, 79241-46-6 fluazifop-butyl 1 103361-09-7 flumioxazin 7-methoxy-6-(3-morpholin-4-yl-propoxy)-3H-quinazolin-4- 1 199327-61-2 one 1 3724-43-4 chloro-N,N-dimethylformiminium chloride 1 85509-19-9 flusilazole cyclic 3-(1,2-ethanediylacetale)-estra-5(10),9(11)-diene-3,17- 1 5571-36-8 dione 1 592-62-1 methyl-ONN-azoxymethyl acetate 1 77182-82-2 glufosinate ammonium 1 288-32-4 imidazole 1 74499-35-7 phenol, (tetrapropenyl) derivatives 1 65277-42-1 ketoconazole 1 330-55-2 linuron 1 1836-75-5 nitrofen 1 119738-06-6 quizalofop-p-téfuryl salts and esters of dinoseb, with the exception of those 1 specified elsewhere in this Annex 1 65996-93-2 pitch, coal tar, high-temp.
Recommended publications
  • C9-14 Aliphatic [2-25% Aromatic] Hydrocarbon Solvents Category SIAP
    CoCAM 2, 17-19 April 2012 BIAC/ICCA SIDS INITIAL ASSESSMENT PROFILE Chemical C -C Aliphatic [2-25% aromatic] Hydrocarbon Solvents Category Category 9 14 Substance Name CAS Number Stoddard solvent 8052-41-3 Chemical Names Kerosine, petroleum, hydrodesulfurized 64742-81-0 and CAS Naphtha, petroleum, hydrodesulfurized heavy 64742-82-1 Registry Solvent naphtha, petroleum, medium aliphatic 64742-88-7 Numbers Note: Substances in this category are also commonly known as mineral spirits, white spirits, or Stoddard solvent. CAS Number Chemical Description † 8052-41-3 Includes C8 to C14 branched, linear, and cyclic paraffins and aromatics (6 to 18%), <50ppmV benzene † 64742-81-0 Includes C9 to C14 branched, linear, and cyclic paraffins and aromatics (10 to Structural 25%), <100 ppmV benzene Formula † and CAS 64742-82-1 Includes C8 to C13 branched, linear, and cyclic paraffins and aromatics (15 to 25%), <100 ppmV benzene Registry † Numbers 64742-88-7 Includes C8 to C13 branched, linear, and cyclic paraffins and aromatics (14 to 20%), <50 ppmV benzene Individual category member substances are comprised of aliphatic hydrocarbon molecules whose carbon numbers range between C9 and C14; approximately 80% of the aliphatic constituents for a given substance fall within the C9-C14 carbon range and <100 ppmV benzene. In some instances, the carbon range of a test substance is more precisely defined in the test protocol. In these instances, the specific carbon range (e.g. C8-C10, C9-C10, etc.) will be specified in the SIAP. * It should be noted that other substances defined by the same CAS RNs may have boiling ranges outside the range of 143-254° C and that these substances are not covered by the category.
    [Show full text]
  • Investigating Non-Targeted Screening and Accurate Quantitation of Trace Surface Water Contaminants Using High-Resolution Mass Spectrometry
    Western University Scholarship@Western Electronic Thesis and Dissertation Repository 8-8-2018 3:00 PM Investigating non-targeted screening and accurate quantitation of trace surface water contaminants using high-resolution mass spectrometry Lucas M. Morrison The University of Western Ontario Supervisor Sumarah, Mark W. The University of Western Ontario Co-Supervisor Yeung, Ken K-C. The University of Western Ontario Graduate Program in Chemistry A thesis submitted in partial fulfillment of the equirr ements for the degree in Master of Science © Lucas M. Morrison 2018 Follow this and additional works at: https://ir.lib.uwo.ca/etd Part of the Analytical Chemistry Commons, and the Environmental Chemistry Commons Recommended Citation Morrison, Lucas M., "Investigating non-targeted screening and accurate quantitation of trace surface water contaminants using high-resolution mass spectrometry" (2018). Electronic Thesis and Dissertation Repository. 5612. https://ir.lib.uwo.ca/etd/5612 This Dissertation/Thesis is brought to you for free and open access by Scholarship@Western. It has been accepted for inclusion in Electronic Thesis and Dissertation Repository by an authorized administrator of Scholarship@Western. For more information, please contact [email protected]. Abstract The human impact on surface water is a growing concern and the chemical surveying of contaminants including pharmaceuticals and pesticides is currently lacking. Neonicotinoids in particular, are among the most widely used insecticides that have prompted environmental concern and require monitoring. Chemical contaminants in environmental water samples are commonly analyzed by targeted tandem mass spectrometry. However, this requires a prior knowledge of the contaminants in the area of interest. Here, surface water samples were screened by utilizing optimized data-independent acquisition (DIA) methods and the spectra were databased for future retrospective analysis.
    [Show full text]
  • California Proposition 65 Toxicity List
    STATE OF CALIFORNIA ENVIRONMENTAL PROTECTION AGENCY OFFICE OF ENVIRONMENTAL HEALTH HAZARD ASSESSMENT SAFE DRINKING WATER AND TOXIC ENFORCEMENT ACT OF 1986 CHEMICALS KNOWN TO THE STATE TO CAUSE CANCER OR REPRODUCTIVE TOXICITY 4-Mar-05 The Safe Drinking Water and Toxic Enforcement Act of 1986 requires that the Governor revise and Chemical Type of Toxicity CAS No. Date Listed A-alpha-C (2-Amino-9H-pyrido[2,3-b]indole) cancer 26148685 1-Jan-90 Acetaldehyde cancer 75070 1-Apr-88 Acetamide cancer 60355 1-Jan-90 Acetazolamide developmental 59665 20-Aug-99 Acetochlor cancer 34256821 1-Jan-89 Acetohydroxamic acid developmental 546883 1-Apr-90 2-Acetylaminofluorene cancer 53963 1-Jul-87 Acifluorfen cancer 62476599 1-Jan-90 Acrylamide cancer 79061 1-Jan-90 Acrylonitrile cancer 107131 1-Jul-87 Actinomycin D cancer 50760 1-Oct-89 Actinomycin D developmental 50760 1-Oct-92 Adriamycin (Doxorubicin hydrochloride) cancer 23214928 1-Jul-87 AF-2;[2-(2-furyl)-3-(5-nitro-2-furyl)]acrylamide cancer 3688537 1-Jul-87 Aflatoxins cancer --- 1-Jan-88 Alachlor cancer 15972608 1-Jan-89 Alcoholic beverages, when associated with alcohol abuse cancer --- 1-Jul-88 Aldrin cancer 309002 1-Jul-88 All-trans retinoic acid developmental 302794 1-Jan-89 Allyl chloride Delisted October 29, 1999 cancer 107051 1-Jan-90 Alprazolam developmental 28981977 1-Jul-90 Altretamine developmental, male 645056 20-Aug-99 Amantadine hydrochloride developmental 665667 27-Feb-01 Amikacin sulfate developmental 39831555 1-Jul-90 2-Aminoanthraquinone cancer 117793 1-Oct-89 p -Aminoazobenzene cancer
    [Show full text]
  • COMBINED LIST of Particularly Hazardous Substances
    COMBINED LIST of Particularly Hazardous Substances revised 2/4/2021 IARC list 1 are Carcinogenic to humans list compiled by Hector Acuna, UCSB IARC list Group 2A Probably carcinogenic to humans IARC list Group 2B Possibly carcinogenic to humans If any of the chemicals listed below are used in your research then complete a Standard Operating Procedure (SOP) for the product as described in the Chemical Hygiene Plan. Prop 65 known to cause cancer or reproductive toxicity Material(s) not on the list does not preclude one from completing an SOP. Other extremely toxic chemicals KNOWN Carcinogens from National Toxicology Program (NTP) or other high hazards will require the development of an SOP. Red= added in 2020 or status change Reasonably Anticipated NTP EPA Haz list COMBINED LIST of Particularly Hazardous Substances CAS Source from where the material is listed. 6,9-Methano-2,4,3-benzodioxathiepin, 6,7,8,9,10,10- hexachloro-1,5,5a,6,9,9a-hexahydro-, 3-oxide Acutely Toxic Methanimidamide, N,N-dimethyl-N'-[2-methyl-4-[[(methylamino)carbonyl]oxy]phenyl]- Acutely Toxic 1-(2-Chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea (Methyl-CCNU) Prop 65 KNOWN Carcinogens NTP 1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) IARC list Group 2A Reasonably Anticipated NTP 1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) (Lomustine) Prop 65 1-(o-Chlorophenyl)thiourea Acutely Toxic 1,1,1,2-Tetrachloroethane IARC list Group 2B 1,1,2,2-Tetrachloroethane Prop 65 IARC list Group 2B 1,1-Dichloro-2,2-bis(p -chloropheny)ethylene (DDE) Prop 65 1,1-Dichloroethane
    [Show full text]
  • OECD Environment Health and Safety Publications Series on Testing and Assessment No
    OECD Environment Health and Safety Publications Series on Testing and Assessment No. 21 Detailed Review Paper Appraisal of Test Methods for Sex Hormone Disrupting Chemicals Environment Directorate ORGANISATION FOR ECONOMIC CO-OPERATION AND DEVELOPMENT Paris May 2001 1 Also Published in the Series Testing and Assessment: No. 1, Guidance Document for the Development of OECD Guidelines for Testing of Chemicals (1993; reformatted 1995) No. 2, Detailed Review Paper on Biodegradability Testing (1995) No. 3, Guidance Document for Aquatic Effects Assessment (1995) No. 4, Report of the OECD Workshop on Environmental Hazard/Risk Assessment (1995) No. 5, Report of the SETAC/OECD Workshop on Avian Toxicity Testing (1996) No. 6, Report of the Final Ring-test of the Daphnia magna Reproduction Test (1997) No. 7, Guidance Document on Direct Phototransformation of Chemicals in Water (1997) No. 8, Report of the OECD Workshop on Sharing Information about New Industrial Chemicals Assessment (1997) No. 9 Guidance Document for the Conduct of Studies of Occupational Exposure to Pesticides During Agricultural Application (1997) No. 10, Report of the OECD Workshop on Statistical Analysis of Aquatic Toxicity Data (1998) No. 11, Detailed Review Paper on Aquatic Testing Methods for Pesticides and industrial Chemicals (1998) No. 12, Detailed Review Document on Classification Systems for Germ Cell Mutagenicity in OECD Member Countries (1998) No. 13, Detailed Review Document on Classification Systems for Sensitising Substances in OECD Member Countries 1998) No. 14, Detailed Review Document on Classification Systems for Eye Irritation/Corrosion in OECD Member Countries (1998) No. 15, Detailed Review Document on Classification Systems for Reproductive Toxicity in OECD Member Countries (1998) No.
    [Show full text]
  • Interactions with PBC Agents
    www.hep-druginteractions.org Interactions with PBC Agents Charts created March 2020. Full information available at www.hep-druginteractions.org Page 1 of 4 Please note that if a drug is not listed it cannot automatically be assumed it is safe to coadminister. Obeticholic Ursodeoxycholic Obeticholic Ursodeoxycholic Obeticholic Ursodeoxycholic Acid Acid Acid Acid Acid Acid Anaesthetics & Muscle Relaxants Antibacterials (continued) Antidepressants Bupivacaine Cloxacillin Agomelatine Cisatracurium Dapsone Amitriptyline Isoflurane Delamanid Bupropion Ketamine Ertapenem Citalopram Nitrous oxide Erythromycin Clomipramine Propofol Ethambutol Desipramine Thiopental Flucloxacillin Desvenlafaxine Tizanidine Gentamicin Dosulepin Analgesics Imipenem Doxepin Aceclofenac Isoniazid Duloxetine Alfentanil Escitalopram Aspirin Levofloxacin Linezolid Fluoxetine Buprenorphine Fluvoxamine Lymecycline distribution. Celecoxib Imipramine Meropenem Codeine Lithium Methenamine Dexketoprofen Maprotiline Metronidazole Dextropropoxyphene Mianserin Moxifloxacin Diamorphine Milnacipran Diclofenac Nitrofurantoin only. Not for distribution. for only. Not Mirtazapine Diflunisal Norfloxacin Moclobemide Dihydrocodeine Ofloxacin Nefazodone Etoricoxib Penicillin V Nortriptyline Fentanyl Piperacillin Paroxetine Flurbiprofen Pivmecillinam Sertraline Hydrocodone use ersonal Pyrazinamide Tianeptine Hydromorphone Rifabutin Trazodone Ibuprofen Rifampicin
    [Show full text]
  • Detection of Estrogen Receptor Endocrine Disruptor Potency of Commonly Used Organochlorine Pesticides Using the LUMI-CELL ER Bioassay
    DEVELOPMENTAL AND REPRODUCTIVE TOXICITY Detection of Estrogen Receptor Endocrine Disruptor Potency of Commonly Used Organochlorine Pesticides Using The LUMI-CELL ER Bioassay John D. Gordon1, Andrew C: Chu1, Michael D. Chu2, Michael S. Denison3, George C. Clark1 1Xenobiotic Detection Systems, Inc., 1601 E. Geer St., Suite S, Durham, NC 27704, USA 2Alta Analytical Perspectives, 2714 Exchange Drive, Wilmington, NC 28405, USA 3Dept. of Environmental Toxicology, Meyer Hall, Univ. of California, Davis; Davis, CA 95616 USA Introduction Organochlorine pesticides are found in many ecosystems worldwide as result of agricultural and industrial activities and exist as complex mixtures. The use of these organochlorine pesticides has resulted in the contamination of lakes and streams, and eventually the animal and human food chain. Many of these pesticides, such as pp ’-DDT, pp ’-DDE, Kepone, Vinclozolin, and Methoxychlor (a substitute for the banned DDT), have been described as putative estrogenic endocrine disruptors, and act by mimicking endogenous estrogen 1-3 . Estrogenic compounds can have a significant detrimental effect on the endocrine and reproductive systems of both human and other animal populations 4 . Previous studies have shown a strong association between several EDCs (17p-Estradiol, DES, Zeralanol, Zeralenone, Coumestrol, Genistein, Biochanin A, Diadzein, Naringenin, Tamoxifin) and estrogenic activity via uterotropic assay, cell height, gland number, increased lactoferrin, and a transcriptional activity assay using BG1Luc4E2 cells4 . Some other examples of the effects of these EDCs are: decreased reproductive success and feminization of males in several wildlife species; increased hypospadias along with reductions in sperm counts in men; increase in the incidence of human breast and prostate cancers; and endometriosis 3-5 .
    [Show full text]
  • WSAVA List of Essential Medicines for Cats and Dogs
    The World Small Animal Veterinary Association (WSAVA) List of Essential Medicines for Cats and Dogs Version 1; January 20th, 2020 Members of the WSAVA Therapeutic Guidelines Group (TGG) Steagall PV, Pelligand L, Page SW, Bourgeois M, Weese S, Manigot G, Dublin D, Ferreira JP, Guardabassi L © 2020 WSAVA All Rights Reserved Contents Background ................................................................................................................................... 2 Definition ...................................................................................................................................... 2 Using the List of Essential Medicines ............................................................................................ 2 Criteria for selection of essential medicines ................................................................................. 3 Anaesthetic, analgesic, sedative and emergency drugs ............................................................... 4 Antimicrobial drugs ....................................................................................................................... 7 Antibacterial and antiprotozoal drugs ....................................................................................... 7 Systemic administration ........................................................................................................ 7 Topical administration ........................................................................................................... 9 Antifungal drugs .....................................................................................................................
    [Show full text]
  • (12) United States Patent (10) Patent No.: US 9.498,431 B2 Xu Et Al
    USOO9498431B2 (12) United States Patent (10) Patent No.: US 9.498,431 B2 Xu et al. (45) Date of Patent: Nov. 22, 2016 (54) CONTROLLED RELEASING COMPOSITION 7,053,134 B2 * 5/2006 Baldwin et al. .............. 522,154 2004/0058056 A1 3/2004 Osaki et al. ................... 427.2.1 (76) Inventors: Jianjian Xu, Hefei (CN); Shiliang 2005/0037047 A1 2/2005 Song Wang, Hefei (CN); Manzhi Ding 2007/0055364 A1* 3/2007 Hossainy .................. A61F 2/82 s: s s 623, 1.38 Hefei (CN) 2008/0274194 A1* 11/2008 Miller .................... A61K 9.146 424/489 (*) Notice: Subject to any disclaimer, the term of this patent is extended or adjusted under 35 FOREIGN PATENT DOCUMENTS U.S.C. 154(b) by 0 days. CN 1208.610 A 2, 1999 (21) Appl. No.: 13/133,656 EP O251680 A2 1, 1988 JP S63-22516. A 1, 1988 JP H1O-310518 A 11, 1998 (22) PCT Filed: Dec. 10, 2009 WO 96,10395 A1 4f1996 WO WO 2005.000277 A1 * 1, 2005 (86). PCT No.: PCT/CN2009/075468 WO 2007 115045 A2 10, 2007 WO 2008/OO2657 A2 1, 2008 S 371 (c)(1), WO 2008OO2657 A2 1, 2008 (2), (4) Date: Jun. 9, 2011 WO 2008041246 A2 4/2008 (87) PCT Pub. No.: WO2010/066203 OTHER PUBLICATIONS PCT Pub. Date: Jun. 17, 2010 Crowley and Zhang, Pharmaceutical Application of Hot Melt Extru (65) Prior Publication Data sion: Part I, Drug Development and Industrial Pharmacy, 2007. 33:909-926.* US 2011/024.4043 A1 Oct. 6, 2011 The Use of Poly (L-Lactide) and RGD Modified Microspheres as Cell Carriers in a Flow Intermittency Bioreactor for Tissue Engi (30) Foreign Application Priority Data neering Cartilage.
    [Show full text]
  • Cycloalkanes, Cycloalkenes, and Cycloalkynes
    CYCLOALKANES, CYCLOALKENES, AND CYCLOALKYNES any important hydrocarbons, known as cycloalkanes, contain rings of carbon atoms linked together by single bonds. The simple cycloalkanes of formula (CH,), make up a particularly important homologous series in which the chemical properties change in a much more dramatic way with increasing n than do those of the acyclic hydrocarbons CH,(CH,),,-,H. The cyclo- alkanes with small rings (n = 3-6) are of special interest in exhibiting chemical properties intermediate between those of alkanes and alkenes. In this chapter we will show how this behavior can be explained in terms of angle strain and steric hindrance, concepts that have been introduced previously and will be used with increasing frequency as we proceed further. We also discuss the conformations of cycloalkanes, especially cyclo- hexane, in detail because of their importance to the chemistry of many kinds of naturally occurring organic compounds. Some attention also will be paid to polycyclic compounds, substances with more than one ring, and to cyclo- alkenes and cycloalkynes. 12-1 NOMENCLATURE AND PHYSICAL PROPERTIES OF CYCLOALKANES The IUPAC system for naming cycloalkanes and cycloalkenes was presented in some detail in Sections 3-2 and 3-3, and you may wish to review that ma- terial before proceeding further. Additional procedures are required for naming 446 12 Cycloalkanes, Cycloalkenes, and Cycloalkynes Table 12-1 Physical Properties of Alkanes and Cycloalkanes Density, Compounds Bp, "C Mp, "C diO,g ml-' propane cyclopropane butane cyclobutane pentane cyclopentane hexane cyclohexane heptane cycloheptane octane cyclooctane nonane cyclononane "At -40". bUnder pressure. polycyclic compounds, which have rings with common carbons, and these will be discussed later in this chapter.
    [Show full text]
  • WO 2018/190970 Al 18 October 2018 (18.10.2018) W !P O PCT
    (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date WO 2018/190970 Al 18 October 2018 (18.10.2018) W !P O PCT (51) International Patent Classification: GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, CI2Q 1/32 (2006.01) UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, (21) International Application Number: EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, PCT/US2018/021 109 MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, (22) International Filing Date: TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, 06 March 2018 (06.03.2018) KM, ML, MR, NE, SN, TD, TG). (25) Filing Language: English Declarations under Rule 4.17: (26) Publication Langi English — as to applicant's entitlement to apply for and be granted a patent (Rule 4.1 7(H)) (30) Priority Data: — as to the applicant's entitlement to claim the priority of the 62/484,141 11 April 2017 ( 11.04.2017) US earlier application (Rule 4.17(Hi)) (71) Applicant: REGENERON PHARMACEUTICALS, Published: INC. [US/US]; 777 Old Saw Mill River Road, Tarrytown, — with international search report (Art. 21(3)) New York 10591-6707 (US). — with sequence listing part of description (Rule 5.2(a)) (72) Inventors: STEVIS, Panayiotis; 777 Old Saw Mill Riv er Road, Tarrytown, New York 10591-6707 (US).
    [Show full text]
  • Download Our Summer 2010 Newsletter
    A n e w s l e t t e r f o r r e f e r r i n g veterinarians JOIN US IN 2011 AS WE CELEBRATE METROPOLITAN VETERINARY ASSOCIATES 25 P roviding emergency care & specialized veterinary services YEARS INSID E: p2-3 WELCOME TO Trilostane for the Treatment of Canine the fourth edition of our newsletter Hyperadrenocorticism – The Answer to Our Problems? Established in 1986, Metropolitan Veterinary Associates & Emergency Services p4 is a veterinary group that provides referral veterinary services. We concentrate Pet Loss Support Group & Monthly Lecture Series on specialty and emergency cases, allowing us to dedicate high-level care to the following disciplines: behavior, cardiology, dentistry, dermatology, I NSERT: emergency, internal medicine, neurology, ophthalmology, radiology front (including CT and MRI) and surgery. Meet our internal medicine team In order to maintain a high level of patient care, MVA moved into a newly back renovated 18,000 square foot facility with state-of-the-art diagnostic and Join us for CE therapeutic equipment in 2006. If you haven’t been able to visit our practice, we hope you can join us at one of the upcoming hospital lectures mentioned on page 4. Please enjoy this newsletter and let us know of any topics of interest you’d like to see explored in future editions. We’ve made it easier to contact us. Catch us 24 HOURS A DAY at 610/666/1050! (our primary phone number) DID YOU KNOW? TRILOSTANE FOR THE TREATMENT OF ! CANINE HYPERADRENOCORTICISM – THE ANSWER TO OUR PROBLEMS? By: Damon B.
    [Show full text]