Chemical Muscle Enhancement (The BDR) by Author L
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Isoflavone Phytoestrogens in Humans
PLEASE TYPE THE UNIVERSITY OF NEW SOUTH WALES Thesis/Project Report Sheet Surname or Family name: Knight First name: David Other name/s: Charles Abbreviation for degree as given in the U niversity calendar: MD Sc hool: O&G Faculty: Title: lsoflavone Phytoestrogens in Humans. The biological effects at different ages from the clinical perspective. Abstract 350 words maximum: (PLEASE TYPE) In Australia the trend toward dietary change by the general public in an attempt to improve health has resulted in an increased consumption of soy based products containing isoflavones. These compounds are selective oestrogen receptor modulators and have described oestrogen agonist and antagonist effects. The aim of this thesis was to assess the biological effects of isoflavones at different stages of reproductive life in humans. The isoflavone content of different foods, formulas and drinks that may be consumed by infants during their first year of life was investigated by measurement with HPLC in an attempt to define levels of exposure on different feeding regimens. All foods tested contained isoflavones, at varying levels, suggesttng that exposure to these compounds is almost ubiquitous. Given the relatively broad choice of infant foods becoming available, exposure to dietary isoflavones during the first year of life is virtually ubiquitous. The exposure may be higher if soy infant formulas are consumed, however the levels attained appear to fall within normal physiological boundaries. Ovarian follicular fluid was collected during oocyte collection during Assisted Reproduction cycles and examined for the presence of isoflavones by HPLC. Genistein was found to be present in ovarian follicular fluid. This is the first demonstration in humans of the presence of isoflavones of dietary origin in ovarian fluid and the presence of these compounds may effect ovarian function. -
California Proposition 65 Toxicity List
STATE OF CALIFORNIA ENVIRONMENTAL PROTECTION AGENCY OFFICE OF ENVIRONMENTAL HEALTH HAZARD ASSESSMENT SAFE DRINKING WATER AND TOXIC ENFORCEMENT ACT OF 1986 CHEMICALS KNOWN TO THE STATE TO CAUSE CANCER OR REPRODUCTIVE TOXICITY 4-Mar-05 The Safe Drinking Water and Toxic Enforcement Act of 1986 requires that the Governor revise and Chemical Type of Toxicity CAS No. Date Listed A-alpha-C (2-Amino-9H-pyrido[2,3-b]indole) cancer 26148685 1-Jan-90 Acetaldehyde cancer 75070 1-Apr-88 Acetamide cancer 60355 1-Jan-90 Acetazolamide developmental 59665 20-Aug-99 Acetochlor cancer 34256821 1-Jan-89 Acetohydroxamic acid developmental 546883 1-Apr-90 2-Acetylaminofluorene cancer 53963 1-Jul-87 Acifluorfen cancer 62476599 1-Jan-90 Acrylamide cancer 79061 1-Jan-90 Acrylonitrile cancer 107131 1-Jul-87 Actinomycin D cancer 50760 1-Oct-89 Actinomycin D developmental 50760 1-Oct-92 Adriamycin (Doxorubicin hydrochloride) cancer 23214928 1-Jul-87 AF-2;[2-(2-furyl)-3-(5-nitro-2-furyl)]acrylamide cancer 3688537 1-Jul-87 Aflatoxins cancer --- 1-Jan-88 Alachlor cancer 15972608 1-Jan-89 Alcoholic beverages, when associated with alcohol abuse cancer --- 1-Jul-88 Aldrin cancer 309002 1-Jul-88 All-trans retinoic acid developmental 302794 1-Jan-89 Allyl chloride Delisted October 29, 1999 cancer 107051 1-Jan-90 Alprazolam developmental 28981977 1-Jul-90 Altretamine developmental, male 645056 20-Aug-99 Amantadine hydrochloride developmental 665667 27-Feb-01 Amikacin sulfate developmental 39831555 1-Jul-90 2-Aminoanthraquinone cancer 117793 1-Oct-89 p -Aminoazobenzene cancer -
Étude in Vivo / in Vitro De L'effet De La Zéaralénone Sur L'expression De
Étude in vivo / in vitro de l’effet de la zéaralénone sur l’expression de transporteurs ABC majeurs lors d’une exposition gestationnelle ou néonatale Farah Koraichi To cite this version: Farah Koraichi. Étude in vivo / in vitro de l’effet de la zéaralénone sur l’expression de transporteurs ABC majeurs lors d’une exposition gestationnelle ou néonatale. Toxicologie. Université Claude Bernard - Lyon I, 2012. Français. NNT : 2012LYO10314. tel-01071280 HAL Id: tel-01071280 https://tel.archives-ouvertes.fr/tel-01071280 Submitted on 3 Oct 2014 HAL is a multi-disciplinary open access L’archive ouverte pluridisciplinaire HAL, est archive for the deposit and dissemination of sci- destinée au dépôt et à la diffusion de documents entific research documents, whether they are pub- scientifiques de niveau recherche, publiés ou non, lished or not. The documents may come from émanant des établissements d’enseignement et de teaching and research institutions in France or recherche français ou étrangers, des laboratoires abroad, or from public or private research centers. publics ou privés. N° d’ordre 314-2012 Année 2012 THESE DE L’UNIVERSITE DE LYON Délivrée par L’UNIVERSITE CLAUDE BERNARD LYON 1 ECOLE DOCTORALE INTERDISCIPLINAIRE SCIENCES-SANTE (EDISS) DIPLOME DE DOCTORAT (arrêté du 7 août 2006) soutenue publiquement le 20 décembre 2012 par Mlle Farah KORAÏCHI TITRE : ETUDE IN VIVO/IN VITRO DE L’EFFET DE LA ZEARALENONE SUR l’EXPRESSION DE TRANSPORTEURS ABC MAJEURS LORS D’UNE EXPOSITION GESTATIONNELLE OU NEONATALE Directeur de thèse: Sylvaine LECOEUR Co-directeur -
COMBINED LIST of Particularly Hazardous Substances
COMBINED LIST of Particularly Hazardous Substances revised 2/4/2021 IARC list 1 are Carcinogenic to humans list compiled by Hector Acuna, UCSB IARC list Group 2A Probably carcinogenic to humans IARC list Group 2B Possibly carcinogenic to humans If any of the chemicals listed below are used in your research then complete a Standard Operating Procedure (SOP) for the product as described in the Chemical Hygiene Plan. Prop 65 known to cause cancer or reproductive toxicity Material(s) not on the list does not preclude one from completing an SOP. Other extremely toxic chemicals KNOWN Carcinogens from National Toxicology Program (NTP) or other high hazards will require the development of an SOP. Red= added in 2020 or status change Reasonably Anticipated NTP EPA Haz list COMBINED LIST of Particularly Hazardous Substances CAS Source from where the material is listed. 6,9-Methano-2,4,3-benzodioxathiepin, 6,7,8,9,10,10- hexachloro-1,5,5a,6,9,9a-hexahydro-, 3-oxide Acutely Toxic Methanimidamide, N,N-dimethyl-N'-[2-methyl-4-[[(methylamino)carbonyl]oxy]phenyl]- Acutely Toxic 1-(2-Chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea (Methyl-CCNU) Prop 65 KNOWN Carcinogens NTP 1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) IARC list Group 2A Reasonably Anticipated NTP 1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) (Lomustine) Prop 65 1-(o-Chlorophenyl)thiourea Acutely Toxic 1,1,1,2-Tetrachloroethane IARC list Group 2B 1,1,2,2-Tetrachloroethane Prop 65 IARC list Group 2B 1,1-Dichloro-2,2-bis(p -chloropheny)ethylene (DDE) Prop 65 1,1-Dichloroethane -
University of Groningen Copper-Catalyzed Asymmetric
University of Groningen Copper-catalyzed asymmetric allylic alkylation and asymmetric conjugate addition in natural product synthesis Huang, Yange IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below. Document Version Publisher's PDF, also known as Version of record Publication date: 2013 Link to publication in University of Groningen/UMCG research database Citation for published version (APA): Huang, Y. (2013). Copper-catalyzed asymmetric allylic alkylation and asymmetric conjugate addition in natural product synthesis. s.n. Copyright Other than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons). The publication may also be distributed here under the terms of Article 25fa of the Dutch Copyright Act, indicated by the “Taverne” license. More information can be found on the University of Groningen website: https://www.rug.nl/library/open-access/self-archiving-pure/taverne- amendment. Take-down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum. Download date: 03-10-2021 Copper-catalyzed Asymmetric Allylic Alkylation and Asymmetric Conjugate Addition in Natural Product Synthesis Yange Huang This Ph.D. -
WSAVA List of Essential Medicines for Cats and Dogs
The World Small Animal Veterinary Association (WSAVA) List of Essential Medicines for Cats and Dogs Version 1; January 20th, 2020 Members of the WSAVA Therapeutic Guidelines Group (TGG) Steagall PV, Pelligand L, Page SW, Bourgeois M, Weese S, Manigot G, Dublin D, Ferreira JP, Guardabassi L © 2020 WSAVA All Rights Reserved Contents Background ................................................................................................................................... 2 Definition ...................................................................................................................................... 2 Using the List of Essential Medicines ............................................................................................ 2 Criteria for selection of essential medicines ................................................................................. 3 Anaesthetic, analgesic, sedative and emergency drugs ............................................................... 4 Antimicrobial drugs ....................................................................................................................... 7 Antibacterial and antiprotozoal drugs ....................................................................................... 7 Systemic administration ........................................................................................................ 7 Topical administration ........................................................................................................... 9 Antifungal drugs ..................................................................................................................... -
WO 2018/190970 Al 18 October 2018 (18.10.2018) W !P O PCT
(12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date WO 2018/190970 Al 18 October 2018 (18.10.2018) W !P O PCT (51) International Patent Classification: GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, CI2Q 1/32 (2006.01) UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, (21) International Application Number: EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, PCT/US2018/021 109 MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, (22) International Filing Date: TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, 06 March 2018 (06.03.2018) KM, ML, MR, NE, SN, TD, TG). (25) Filing Language: English Declarations under Rule 4.17: (26) Publication Langi English — as to applicant's entitlement to apply for and be granted a patent (Rule 4.1 7(H)) (30) Priority Data: — as to the applicant's entitlement to claim the priority of the 62/484,141 11 April 2017 ( 11.04.2017) US earlier application (Rule 4.17(Hi)) (71) Applicant: REGENERON PHARMACEUTICALS, Published: INC. [US/US]; 777 Old Saw Mill River Road, Tarrytown, — with international search report (Art. 21(3)) New York 10591-6707 (US). — with sequence listing part of description (Rule 5.2(a)) (72) Inventors: STEVIS, Panayiotis; 777 Old Saw Mill Riv er Road, Tarrytown, New York 10591-6707 (US). -
Download Our Summer 2010 Newsletter
A n e w s l e t t e r f o r r e f e r r i n g veterinarians JOIN US IN 2011 AS WE CELEBRATE METROPOLITAN VETERINARY ASSOCIATES 25 P roviding emergency care & specialized veterinary services YEARS INSID E: p2-3 WELCOME TO Trilostane for the Treatment of Canine the fourth edition of our newsletter Hyperadrenocorticism – The Answer to Our Problems? Established in 1986, Metropolitan Veterinary Associates & Emergency Services p4 is a veterinary group that provides referral veterinary services. We concentrate Pet Loss Support Group & Monthly Lecture Series on specialty and emergency cases, allowing us to dedicate high-level care to the following disciplines: behavior, cardiology, dentistry, dermatology, I NSERT: emergency, internal medicine, neurology, ophthalmology, radiology front (including CT and MRI) and surgery. Meet our internal medicine team In order to maintain a high level of patient care, MVA moved into a newly back renovated 18,000 square foot facility with state-of-the-art diagnostic and Join us for CE therapeutic equipment in 2006. If you haven’t been able to visit our practice, we hope you can join us at one of the upcoming hospital lectures mentioned on page 4. Please enjoy this newsletter and let us know of any topics of interest you’d like to see explored in future editions. We’ve made it easier to contact us. Catch us 24 HOURS A DAY at 610/666/1050! (our primary phone number) DID YOU KNOW? TRILOSTANE FOR THE TREATMENT OF ! CANINE HYPERADRENOCORTICISM – THE ANSWER TO OUR PROBLEMS? By: Damon B. -
Scienze Veterinarie
Alma Mater Studiorum – Università di Bologna DOTTORATO DI RICERCA IN SCIENZE VETERINARIE Ciclo XXX Settore Concorsuale: 07/H2 Settore Scientifico Disciplinare: VET/04 MYCOTOXIN DETERMINATION IN NON CONVENTIONAL MATRICES: DEVELOPMENT OF MASS SPECTROMETRY BASED ANALYTICAL METHODS Presentata da: Dott.ssa Adele Repossi Coordinatore Dottorato Supervisore Chiar.mo Prof. Arcangelo Gentile Chiar.ma Prof.ssa Teresa Gazzotti Esame finale anno 2018 ABSTRACT Mycotoxins are low-molecular-weight natural products produced, as secondary metabolites, by filamentous fungi. These molecules represent a wide chemical group with different toxicity effects in human and other animals. These toxins can accidentally occur in food and feed, due to a direct or indirect contamination. The aim of this work was to develop a method for the first time to quantitatively determine zearalenone and its metabolites (α-zearalenol, β-zearalenol, α-zearalanol, β-zearalanol, zearalanone) in bovine and human hair using LC-MS/MS. Once the method was set-up for bovine hair, it was successfully validated according to Decision 657/2002/CE on three analytes, with satisfying performances. Moreover the applicability of the method was tested on human hair in a one-day validation with reasonable performances. This method could be a useful tool to evaluate natural feed contamination or detect illegal use of α- zearalanol in bovines and to perform a first inventory of the occurrence of these molecules in bovine and human hair, as biomarkers for zearalenone exposure in future studies. Another purpose of this work was to make a preliminary screening on mycotoxins contamination (aflatoxin B1, aflatoxin B2, aflatoxin G1, aflatoxin G2, deoxynivalenol, zearalenone, fumonisin B1, fumonisin B2, ochratoxin, T-2 toxin and HT-2 toxin) in different pet food types for cats. -
Order in Council 1243/1995
PROVINCE OF BRITISH COLUMBIA ORDER OF THE LIEUTENANT GOVERNOR IN COUNCIL Order in Council No. 12 4 3 , Approved and Ordered OCT 121995 Lieutenant Governor Executive Council Chambers, Victoria On the recommendation of the undersigned, the Lieutenant Governor, by and with the advice and consent of the Executive Council, orders that Order in Council 1039 made August 17, 1995, is rescinded. 2. The Drug Schedules made by regulation of the Council of the College of Pharmacists of British Columbia, as set out in the attached resolution dated September 6, 1995, are hereby approved. (----, c" g/J1"----c- 4- Minister of Heal fandand Minister Responsible for Seniors Presidin Member of the Executive Council (This pan is for adnwustratlye purposes only and is not part of the Order) Authority under which Order Is made: Act and section:- Pharmacists, Pharmacy Operations and Drug Scheduling Act, section 59(2)(1), 62 Other (specify): - Uppodukoic1enact N6145; Resolution of the Council of the College of Pharmacists of British Columbia ("the Council"), made by teleconference at Vancouver, British Columbia, the 6th day of September 1995. RESOLVED THAT: In accordance with the authority established in Section 62 of the Pharmacists, Pharmacy Operations and Drug Scheduling Act of British Columbia, S.B.C. Chapter 62, the Council makes the Drug Schedules by regulation as set out in the attached schedule, subject to the approval of the Lieutenant Governor in Council. Certified a true copy Linda J. Lytle, Phr.) Registrar DRUG SCHEDULES to the Pharmacists, Pharmacy Operations and Drug Scheduling Act of British Columbia The Drug Schedules have been printed in an alphabetical format to simplify the process of locating each individual drug entry and determining its status in British Columbia. -
The Effect of Different Doses of Zearalenone in Feed on The
toxins Article The Effect of Different Doses of Zearalenone in Feed on the Bioavailability of Zearalenone and Alpha-Zearalenol, and the Concentrations of Estradiol and Testosterone in the Peripheral Blood of Pre-Pubertal Gilts Łukasz Zielonka 1, Magdalena Gaj˛ecka 1,*, Sylwia Lisieska-Zołnierczyk˙ 2, Michał D ˛abrowski 1 and Maciej T. Gaj˛ecki 1 1 Department of Veterinary Prevention and Feed Hygiene, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, Oczapowskiego 13/29, 10-718 Olsztyn, Poland; [email protected] (Ł.Z.); [email protected] (M.D.); [email protected] (M.T.G.) 2 Independent Public Health Care Center of the Ministry of the Interior and Administration, and the Warmia and Mazury Oncology Center in Olsztyn, Wojska Polskiego 37, 10-228 Olsztyn, Poland; [email protected] * Correspondence: [email protected]; Tel.: +48-89-523-37-73; Fax: +48-89-523-3618 Received: 31 January 2020; Accepted: 24 February 2020; Published: 26 February 2020 Abstract: The objective of this study was to determine the effect of long-term (48 days), per os administration of specific zearalenone (ZEN) doses (20 and 40 µg ZEN/kg BW in experimental groups EI and EII, which were equivalent to 200% and 400% of the upper range limit of the no-observed-adverse-effect-level (NOAEL), respectively) on the bioavailability of ZEN and the rate of changes in estradiol and testosterone concentrations in the peripheral blood of pre-pubertal gilts. ZEN and α-ZEL levels were similar until day 28. After day 28, α-ZEL concentrations increased significantly in group EI, whereas a significant rise in ZEN levels was noted in group EII. -
Bioactivation of Zearalenone by Porcine Hepatic Biotransformation
Vet. Res. 36 (2005) 799–810 799 © INRA, EDP Sciences, 2005 DOI: 10.1051/vetres:2005034 Original article Bioactivation of zearalenone by porcine hepatic biotransformation Hassan MALEKINEJAD, Roel Franciscus MAAS-BAKKER, Johanna FINK-GREMMELS* Department of Veterinary Pharmacology, Pharmacy and Toxicology, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 16, 3508 TD Utrecht, The Netherlands (Received 18 June 2004; accepted 4 April 2005) Abstract – Zearalenone (ZEA) is a resorcylic acid lactone derivative produced by various Fusarium species that are widely found in food and feeds. The structure of zearalenone is flexible enough to allow a conformation able to bind to mammalian oestrogen receptors, where it acts as an agonist. Using oestrogen-dependent Human Breast Cancer (MCF-7) cells, the oestrogenic activity of zearalenone and its derivatives were compared using 17 β-oestradiol as a positive control. The results obtained demonstrate that the oestrogenic potency of ZEA derivatives could be ranked in the following order: α- zearalenol > α-zearalanol > zearalenone > β-zearalenol. Since pigs have been reported to be among the most sensitive animal species, biotransformation studies with pig liver subcellular fractions were conducted. These studies indicated that α-zearalenol is the main hepatic metabolite of zearalenone in pigs, and it is assumed that 3α- and 3β-hydroxysteroid dehydrogeneases are involved in the hepatic biotransformation, since the formation of α-zearalenol and β-zearalenol could be inhibited by prototypic substrates for either enzyme. The bioactivation of ZEA into the more active α-zearalenol seems to provide a possible explanation for the observed high sensitivity of pigs towards feedingstuffs contaminated with the mycotoxin.