March 17, 2020 u vol. 117 u no. 11

From the Cover

5694 Algal darkening of glacier ice 5836 Structure of human opioid receptor 5949 Poultry trade and avian flu 6014 How mushrooms kill nematodes 6223 Regulating sucrose transporters in plants

Contents

THIS WEEK IN PNAS Cover image: Pictured is an algal bloom 5545 In This Issue on the surface of the Greenland Ice Sheet (GrIS). By studying the biooptical properties of algal bloom on the surface INNER WORKINGS—An over-the-shoulder look at scientists at work of the GrIS, Christopher J. Williamson et 5547 Understanding the evolution of cell types to explain the roots of al. examined how algae darken and animal diversity enhance melting of surface ice. Glacier Viviane Callier algae survive the extreme surface conditions of low temperatures and intense light with the help of secondary COMMENTARIES phenolic pigmentation, which captures 5550 Histamine provides an original vista on cardiorenal syndrome UV and visible light energy, shading Pierre-Louis Tharaux algal chloroplasts and generating heat See companion article on page 3150 in issue 6 of volume 117 to produce meltwater around algal cells. The pigmentation is also responsible for 5553 Do the social roles that women and men occupy in science allow equal access widespread darkening of the GrIS to publication? surface during summer melt months. Alice H. Eagly See the article by Williamson et al. on See companion article on page 4609 in issue 9 of volume 117 pages 5694–5705. Image courtesy of 5556 Late-life costs of raising sons in bighorn sheep Jenine McCutcheon. Hannah Froy and Marle`ne Gamelon See companion article on page 4850 in issue 9 of volume 117

PERSPECTIVE 5559 Science is not a signal detection problem Brent M. Wilson, Christine R. Harris, and John T. Wixted

LETTERS 5568 Complex “human−vegetation−climate” interactions in the Late Holocene and their significance for paleotemperature reconstructions Yunxia Li, Yiping Tian, Haichun Guo, Shikai Wei, Jiantao Cao, Chao Huang, Fuxi Shi, and Zhiguo Rao 5571 Reply to Li et al.: Human societies began to play a significant role in global sediment transfer 4,000 years ago Jean-Philippe Jenny, Sujan Koirala, Irene Gregory-Eaves, Pierre Francus, Bernhard Ahrens, Victor Brovkin, Antti E. K. Ojala, Bernd Zolitschka, Juergen Bader, and Nuno Carvalhais 5573 Apes, adaptations, and artifacts of anesthetics Bjarke Jensen and Tobias Wang

Free online through the PNAS open access option. PNAS u March 17, 2020 u vol. 117 u no. 11 u iii–viii Downloaded by guest on September 28, 2021 5574 Reply to Jensen and Wang: Chimpanzees under 5733 Systematic identification of engineered methionines pressure—Selection of a left ventricular and oxaziridines for efficient, stable, and structural and functional phenotype site-specific antibody bioconjugation Robert E. Shave, Daniel E. Lieberman, Aimee L. Drane, Susanna K. Elledge, Hai L. Tran, Alec H. Christian, Veronica and Aaron L. Baggish Steri, Byron Hann, F. Dean Toste, Christopher J. Chang, and James A. Wells

PHYSICAL SCIENCES COMPUTER SCIENCES

APPLIED PHYSICAL SCIENCES 5624 Communication cost of consensus for nodes with limited memory 5576 Possibility for inhibited spontaneous emission in Giulia Fanti, Nina Holden, Yuval Peres, and Gireeja Ranade electromagnetically open parity–time-symmetric guiding structures 5631 The impossibility of low-rank representations Yakir Hadad and Nader Engheta for triangle-rich complex networks C. Seshadhri, Aneesh Sharma, Andrew Stolman, and Ashish Goel 5582 Coherent phonon dynamics in spatially separated graphene mechanical resonators EARTH, ATMOSPHERIC, AND PLANETARY SCIENCES Zhuo-Zhi Zhang, Xiang-Xiang Song, Gang Luo, Zi-Jia Su, Kai-Long Wang, Gang Cao, Hai-Ou Li, Ming Xiao, 5638 Stability of H3O at extreme conditions and implications Guang-Can Guo, Lin Tian, Guang-Wei Deng, for the magnetic fields of Uranus and Neptune and Guo-Ping Guo Peihao Huang, Hanyu Liu, Jian Lv, Quan Li, Chunhong Long, 5588 In situ healing of dendrites in a potassium Yanchao Wang, Changfeng Chen, Russell J. Hemley, and Yanming Ma metal battery Prateek Hundekar, Swastik Basu, Xiulin Fan, Lu Li, Anthony 5943 Microbial evolutionary strategies in a dynamic ocean Yoshimura, Tushar Gupta, Varun Sarbada, Aniruddha Lakhnot, Nathan G. Walworth, Emily J. Zakem, John P. Dunne, Sine´ad Rishabh Jain, Shankar Narayanan, Yunfeng Shi, Chunsheng Collins, and Naomi M. Levine Wang, and Nikhil Koratkar ENGINEERING

BIOPHYSICS AND COMPUTATIONAL BIOLOGY 5644 Sonoselective transfection of cerebral vasculature without blood–brain barrier disruption 5595 Investigations of the underlying mechanisms of α Catherine M. Gorick, Alexander S. Mathew, William J. Garrison, HIF-1 and CITED2 binding to TAZ1 E. Andrew Thim, Delaney G. Fisher, Caitleen A. Copeland, Ji Wen-Ting Chu, Xiakun Chu, and Jin Wang Song, Alexander L. Klibanov, G. Wilson Miller, and Richard J. Price 5604 Active volume regulation in adhered cells 5655 Mechanophenotyping of 3D multicellular clusters Ram M. Adar and Samuel A. Safran using displacement arrays of rendered tractions 5836 The atomistic level structure for the activated human Susan E. Leggett, Mohak Patel, Thomas M. Valentin, Lena κ-opioid receptor bound to the full Gi protein Gamboa, Amanda S. Khoo, Evelyn Kendall Williams, Christian and the MP1104 agonist Franck, and Ian Y. Wong Amirhossein Mafi, Soo-Kyung Kim, and William A. Goddard III 5664 The effects of evolutionary adaptations on spreading 5844 Abrogation of prenucleation, transient oligomerization processes in complex networks of the Huntingtin exon 1 protein by human Rashad Eletreby, Yong Zhuang, Kathleen M. Carley, Osman profilin I Yagan,˘ and H. Vincent Poor Alberto Ceccon, Vitali Tugarinov, Rodolfo Ghirlando, 5671 Embedded droplet printing in yield-stress fluids and G. Marius Clore Arif Z. Nelson, Binu Kundukad, Wai Kuan Wong, Saif A. Khan, 5853 Cas9 interrogates DNA in discrete steps modulated and Patrick S. Doyle by mismatches and supercoiling 5680 Hierarchically porous Au nanostructures with Ivan E. Ivanov, Addison V. Wright, Joshua C. Cofsky, Kevin D. interconnected channels for efficient mass Palacio Aris, Jennifer A. Doudna, and Zev Bryant transport in electrocatalytic CO2 reduction 5861 Charge-dependent interactions of monomeric and Gayea Hyun, Jun Tae Song, Changui Ahn, Youngjin Ham, filamentous actin with lipid bilayers Donghwi Cho, Jihun Oh, and Seokwoo Jeon Carsten F. E. Schroer, Lucia Baldauf, Lennard van Buren, 5686 Extreme mechanical resilience of self-assembled Tsjerk A. Wassenaar, Manuel N. Melo, Gijsje H. Koenderink, nanolabyrinthine materials and Siewert J. Marrink Carlos M. Portela, A. Vidyasagar, Sebastian Kro¨del, 6156 Active efficient coding explains the development of Tamara Weissenbach, Daryl W. Yee, Julia R. Greer, binocular vision and its failure in amblyopia and Dennis M. Kochmann Samuel Eckmann, Lukas Klimmasch, Bertram E. Shi, and Jochen Triesch ENVIRONMENTAL SCIENCES 5694 Algal photophysiology drives darkening and melt of the Greenland Ice Sheet CHEMISTRY Christopher J. Williamson, Joseph Cook, Andrew Tedstone, 5610 Association of Cl with C2H2 by unified variable- Marian Yallop, Jenine McCutcheon, Ewa Poniecka, Douglas reaction-coordinate and reaction-path Campbell, Tristram Irvine-Fynn, James McQuaid, Martyn variational transition-state theory Tranter, Rupert Perkins, and Alexandre Anesio Linyao Zhang, Donald G. Truhlar, and Shaozeng Sun 5617 Programming colloidal bonding using DNA PHYSICS strand-displacement circuitry 5706 Topological transition in measurement-induced Xiang Zhou, Dongbao Yao, Wenqiang Hua, Ningdong Huang, geometric phases Xiaowei Chen, Liangbin Li, Miao He, Yunhan Zhang, Yijun Guo, Valentin Gebhart, Kyrylo Snizhko (Кирило Сніжко), Thomas Shiyan Xiao, Fenggang Bian, and Haojun Liang Wellens, Andreas Buchleitner, Alessandro Romito, and Yuval Gefen

iv u www.pnas.org Contents Downloaded by guest on September 28, 2021 5714 Experimental observation of the marginal glass phase 5791 bioPROTACs as versatile modulators of intracellular in a colloidal glass therapeutic targets including proliferating cell Andrew P. Hammond and Eric I. Corwin nuclear antigen (PCNA) Shuhui Lim, Regina Khoo, Khong Ming Peh, Jinkai Teo, Shih Chieh Chang, Simon Ng, Greg L. Beilhartz, Roman A. Melnyk, SOCIAL SCIENCES Charles W. Johannes, Christopher J. Brown, David P. Lane, Brian Henry, and Anthony W. Partridge ENVIRONMENTAL SCIENCES 5801 RNA extension drives a stepwise displacement of an 5719 Coastal wetlands reduce property damage during initiation-factor structural module in tropical cyclones initial transcription Fanglin Sun and Richard T. Carson Lingting Li, Vadim Molodtsov, Wei Lin, Richard H. Ebright, and Yu Zhang PSYCHOLOGICAL AND COGNITIVE SCIENCES 5810 Plasmodium chaperonin TRiC/CCT identified as 5726 The neural signature of numerosity by separating a target of the antihistamine clemastine using numerical and continuous magnitude extraction parallel chemoproteomic strategy in visual cortex with frequency-tagged EEG Kuan-Yi Lu, Baiyi Quan, Kayla Sylvester, Tamanna Srivastava, Amandine Van Rinsveld, Mathieu Guillaume, Peter J. Kohler, Michael C. Fitzgerald, and Emily R. Derbyshire Christine Schiltz, Wim Gevers, and Alain Content 5818 Mechanism of proton transfer in class A β-lactamase 6163 Connectivity at the origins of domain specificity in the catalysis and inhibition by avibactam cortical face and place networks Orville A. Pemberton, Radwan E. Noor, Vasantha Kumar M. V., Frederik S. Kamps, Cassandra L. Hendrix, Patricia A. Brennan, Ruslan Sanishvili, M. Trent Kemp, Fiona L. Kearns, H. Lee and Daniel D. Dilks Woodcock, Ioannis Gelis, and Yu Chen 6246 Eye movements support behavioral 5826 Composition-based prediction and rational pattern completion manipulation of prion-like domain recruitment Jordana S. Wynn, Jennifer D. Ryan, and Bradley R. Buchsbaum to stress granules Amy E. Boncella, Jenifer E. Shattuck, Sean M. Cascarina, BIOLOGICAL SCIENCES Kacy R. Paul, Matthew H. Baer, Anastasia Fomicheva, Andrew K. Lamb, and Eric D. Ross APPLIED BIOLOGICAL SCIENCES 5644 Sonoselective transfection of cerebral vasculature BIOPHYSICS AND COMPUTATIONAL BIOLOGY – without blood brain barrier disruption 5595 Investigations of the underlying mechanisms of Catherine M. Gorick, Alexander S. Mathew, William J. Garrison, HIF-1α and CITED2 binding to TAZ1 E. Andrew Thim, Delaney G. Fisher, Caitleen A. Copeland, Ji Wen-Ting Chu, Xiakun Chu, and Jin Wang Song, Alexander L. Klibanov, G. Wilson Miller, and Richard J. Price 5655 Mechanophenotyping of 3D multicellular clusters BIOCHEMISTRY using displacement arrays of rendered tractions 5733 Systematic identification of engineered methionines Susan E. Leggett, Mohak Patel, Thomas M. Valentin, Lena Gamboa, Amanda S. Khoo, Evelyn Kendall Williams, Christian and oxaziridines for efficient, stable, and Franck, and Ian Y. Wong site-specific antibody bioconjugation Susanna K. Elledge, Hai L. Tran, Alec H. Christian, Veronica 5836 The atomistic level structure for the activated human κ Steri, Byron Hann, F. Dean Toste, Christopher J. Chang, -opioid receptor bound to the full Gi protein and James A. Wells and the MP1104 agonist 5741 In vitro selection of ribozyme ligases that use Amirhossein Mafi, Soo-Kyung Kim, and William A. Goddard III prebiotically plausible 2-aminoimidazole– 5844 Abrogation of prenucleation, transient oligomerization activated substrates of the Huntingtin exon 1 protein by human Travis Walton, Saurja DasGupta, Daniel Duzdevich, Seung Soo profilin I Oh, and Jack W. Szostak Alberto Ceccon, Vitali Tugarinov, Rodolfo Ghirlando, 5749 Localization of sterols and oxysterols in mouse brain and G. Marius Clore reveals distinct spatial cholesterol metabolism 5853 Cas9 interrogates DNA in discrete steps modulated Eylan Yutuc, Roberto Angelini, Mark Baumert, Natalia Mast, Irina by mismatches and supercoiling Pikuleva, Jillian Newton, Malcolm R. Clench, David O. F. Ivan E. Ivanov, Addison V. Wright, Joshua C. Cofsky, Kevin D. Skibinski, Owain W. Howell, Yuqin Wang, and William J. Griffiths Palacio Aris, Jennifer A. Doudna, and Zev Bryant 5761 Circadian control of interferon-sensitive gene 5861 Charge-dependent interactions of monomeric and expression in murine skin filamentous actin with lipid bilayers Elyse Noelani Greenberg, Michaela Ellen Marshall, Suoqin Carsten F. E. Schroer, Lucia Baldauf, Lennard van Buren, Jin, Sanan Venkatesh, Morgan Dragan, Lam C. Tsoi, Tsjerk A. Wassenaar, Manuel N. Melo, Gijsje H. Koenderink, Johann E. Gudjonsson, Qing Nie, Joseph S. Takahashi, and Siewert J. Marrink and Bogi Andersen 5873 Epistatic contributions promote the unification of 5772 Conformational control of small GTPases incompatible models of neutral molecular evolution by AMPylation Jose Alberto de la Paz, Charisse M. Nartey, Monisha Yuvaraj, Katja Barthelmes, Evelyn Ramcke, Hyun-Seo Kang, Michael and Faruck Morcos Sattler, and Aymelt Itzen 5883 TDP-43 α-helical structure tunes liquid–liquid phase 5782 SOX4-mediated repression of specific tRNAs inhibits separation and function proliferation of human glioblastoma cells Alexander E. Conicella, Gregory L. Dignon, Gu¨l H. Zerze, Jianjing Yang, Derek K. Smith, Haoqi Ni, Ke Wu, Dongdong Hermann Broder Schmidt, Alexandra M. D’Ordine, Young C. Huang, Sishi Pan, Adwait A. Sathe, Yu Tang, Meng-Lu Liu, Chao Kim, Rajat Rohatgi, Yuna M. Ayala, Jeetain Mittal, Xing, Chun-Li Zhang, and Qichuan Zhuge and Nicolas L. Fawzi

Contents PNAS u March 17, 2020 u vol. 117 u no. 11 u v Downloaded by guest on September 28, 2021 5895 An allosteric switch regulates Mycobacterium 5970 Clonemate cotransmission supports a role for kin tuberculosis ClpP1P2 protease function as selection in a puppeteer parasite established by cryo-EM and methyl-TROSY NMR Charles D. Criscione, Bradley J. van Paridon, John S. Gilleard, Siavash Vahidi, Zev A. Ripstein, Jordan B. Juravsky, Enrico and Cameron P. Goater Rennella, Alfred L. Goldberg, Anthony K. Mittermaier, John L. 5977 Integrated structural and evolutionary analysis Rubinstein, and Lewis E. Kay reveals common mechanisms underlying 5907 Frameshifting preserves key physicochemical adaptive evolution in mammals properties of proteins Greg Slodkowicz and Nick Goldman Lukas Bartonek, Daniel Braun, and Bojan Zagrovic

CELL BIOLOGY GENETICS 5913 Tetraspanin-6 negatively regulates 5987 Caenorhabditis elegans ADAR editing and the exosome production ERI-6/7/MOV10 RNAi pathway silence endogenous Rania Ghossoub, Marion Che´ry, Ste´phane Audebert, Raphael viral elements and LTR retrotransposons Leblanc, Antonio Luis Egea-Jimenez, Fre´de´rique Lembo, Sylvia E. J. Fischer and Gary Ruvkun Sarah Mammar, Flavien Le Dez, Luc Camoin, Jean-Paul Borg, 5997 Assessing thyroid cancer risk using polygenic Eric Rubinstein, Guido David, and Pascale Zimmermann risk scores 5923 Cyp2c44 regulates prostaglandin synthesis, Sandya Liyanarachchi, Julius Gudmundsson, Egil lymphangiogenesis, and metastasis in a Ferkingstad, Huiling He, Jon G. Jonasson, Vinicius mouse model of breast cancer Tragante, Folkert W. Asselbergs, Li Xu, Lambertus A. Rushendhiran Kesavan, Timo Fro¨mel, Sven Zukunft, Hebatullah Kiemeney, Romana T. Netea-Maier, Jose I. Mayordomo, Laban, Alexandra Geyer, Zumer Naeem, Juliana Heidler, Ilka Theo S. Plantinga, Hannes Hjartarson, Jon Hrafnkelsson, Wittig, Eiman Elwakeel, Bernhard Bru¨ne, Andreas Weigert, Erich M. Sturgis, Pamela Brock, Fadi Nabhan, Gudmar Ru¨diger Popp, and Ingrid Fleming Thorleifsson, Matthew D. Ringel, Kari Stefansson, and Albert de la Chapelle 5931 The functional activity of E-cadherin controls tumor cell metastasis at multiple steps 6003 The regulatory and transcriptional landscape Tae-Young Na, Leslayann Schecterson, Alisha M. Mendonsa, associated with carbon utilization in a and Barry M. Gumbiner filamentous fungus Vincent W. Wu, Nils Thieme, Lori B. Huberman, Axel DEVELOPMENTAL BIOLOGY Dietschmann, David J. Kowbel, Juna Lee, Sara Calhoun, 5938 Unique reproductive strategy in the swamp wallaby Vasanth R. Singan, Anna Lipzen, Yi Xiong, Remo Monti, Matthew J. Blow, Ronan C. O’Malley, Igor V. Grigoriev, Brandon R. Menzies, Thomas B. Hildebrandt, J. Philipp Benz, and N. Louise Glass and Marilyn B. Renfree 6014 Sensory cilia as the Achilles heel of nematodes when ECOLOGY attacked by carnivorous mushrooms 5694 Algal photophysiology drives darkening and melt of Ching-Han Lee, Han-Wen Chang, Ching-Ting Yang, Niaz Wali, the Greenland Ice Sheet Jiun-Jie Shie, and Yen-Ping Hsueh Christopher J. Williamson, Joseph Cook, Andrew Tedstone, 6023 Loss-of-function BK channel mutation causes Marian Yallop, Jenine McCutcheon, Ewa Poniecka, Douglas impaired mitochondria and progressive Campbell, Tristram Irvine-Fynn, James McQuaid, Martyn cerebellar ataxia Tranter, Rupert Perkins, and Alexandre Anesio Xiaofei Du, Joao L. Carvalho-de-Souza, Cenfu Wei, Willy Carrasquel-Ursulaez, Yenisleidy Lorenzo, Naileth Gonzalez, ENVIRONMENTAL SCIENCES Tomoya Kubota, Julia Staisch, Timothy Hain, Natalie 5943 Microbial evolutionary strategies in a dynamic ocean Petrossian, Michael Xu, Ramon Latorre, Francisco Bezanilla, Nathan G. Walworth, Emily J. Zakem, John P. Dunne, Sine´ad and Christopher M. Gomez Collins, and Naomi M. Levine 6035 DNA polymerase δ proofreads errors made by 5949 Assessing the role of live poultry trade in community- DNA polymerase e structured transmission of avian influenza in China Chelsea R. Bulock, Xuanxuan Xing, and Polina V. Shcherbakova Qiqi Yang, Xiang Zhao, Philippe Lemey, Marc A. Suchard, Yuhai Bi, Weifeng Shi, Di Liu, Wenbao Qi, Guogang Zhang, Nils Chr. Stenseth, Oliver G. Pybus, and Huaiyu Tian IMMUNOLOGY AND INFLAMMATION 6042 Regulatory CD8 T cells that recognize Qa-1 EVOLUTION expressed by CD4 T-helper cells inhibit 5955 Sympatric speciation of wild emmer wheat driven by rejection of heart allografts ecology and chromosomal rearrangements John Y. Choi, Siawosh K. Eskandari, Songjie Cai, Ina Sulkaj, Hongwei Wang, Huayan Yin, Chengzhi Jiao, Xiaojian Fang, Jean Pierre Assaker, Hazim Allos, Juliano AlHaddad, Saif A. Guiping Wang, Guangrong Li, Fei Ni, Penghuan Li, Peisen Su, Muhsin, Eman Alhussain, Amr Mansouri, Melissa Y. Yeung, Wenyang Ge, Zhongfan Lyu, Shoushen Xu, Yanhong Yang, Marc A. J. Seelen, Hye-Jung Kim, Harvey Cantor, Yongchao Hao, Xinxin Cheng, Jinxiao Zhao, Cheng Liu, and Jamil R. Azzi Fengfeng Xu, Xin Ma, Silong Sun, Yan Zhao, Yinguang Bao, 6047 Lactate dehydrogenase inhibition synergizes with + Cheng Liu, Jingjing Zhang, Tomas Pavlicek, Anfei Li, Zujun IL-21 to promote CD8 T cell stemness and Yang, Eviatar Nevo, and Lingrang Kong antitumor immunity 5964 Dramatic dietary shift maintains sequestered toxins Dalton Hermans, Sanjivan Gautam, Juan C. Garcı´a-Can˜averas, in chemically defended snakes Daniel Gromer, Suman Mitra, Rosanne Spolski, Peng Li, Tatsuya Yoshida, Rinako Ujiie, Alan H. Savitzky, Teppei Jono, Stephen Christensen, Rosa Nguyen, Jian-Xin Lin, Jangsuk Takato Inoue, Naoko Yoshinaga, Shunsuke Aburaya, Wataru Oh, Ning Du, Sharon Veenbergen, Jessica Fioravanti, Aoki, Hirohiko Takeuchi, Li Ding, Qin Chen, Chengquan Cao, Risa Ebina-Shibuya, Christopher Bleck, Leonard M. Tein-Shun Tsai, Anslem de Silva, Dharshani Mahaulpatha, Tao Neckers, Joshua D. Rabinowitz, Luca Gattinoni, Thien Nguyen, Yezhong Tang, Naoki Mori, and Akira Mori and Warren J. Leonard

vi u www.pnas.org Contents Downloaded by guest on September 28, 2021 6056 Histone H3K27me3 demethylases regulate human NEUROSCIENCE Th17 cell development and effector functions by 5726 The neural signature of numerosity by separating impacting on metabolism numerical and continuous magnitude extraction Adam P. Cribbs, Stefan Terlecki-Zaniewicz, Martin Philpott, in visual cortex with frequency-tagged EEG Jeroen Baardman, David Ahern, Morten Lindow, Susanna Amandine Van Rinsveld, Mathieu Guillaume, Peter J. Kohler, Obad, Henrik Oerum, Brante Sampey, Palwinder K. Mander, Christine Schiltz, Wim Gevers, and Alain Content Henry Penn, Paul Wordsworth, Paul Bowness, Menno de Winther, Rab K. Prinjha, Marc Feldmann, and Udo Oppermann 6156 Active efficient coding explains the development of binocular vision and its failure in amblyopia 6067 Signaling mechanisms of growth hormone-releasing Samuel Eckmann, Lukas Klimmasch, Bertram E. Shi, hormone receptor in LPS-induced acute and Jochen Triesch ocular inflammation Wei Cheng Liang, Jia Lin Ren, Qiu Xiao Yu, Jian Li, Tsz Kin Ng, 6163 Connectivity at the origins of domain specificity in the Wai Kit Chu, Yong Jie Qin, Kai On Chu, Andrew V. Schally, Chi cortical face and place networks Pui Pang, and Sun On Chan Frederik S. Kamps, Cassandra L. Hendrix, Patricia A. Brennan, and Daniel D. Dilks MEDICAL SCIENCES 6170 Diet modulates brain network stability, a biomarker 6075 Abrogation of esophageal carcinoma development in for brain aging, in young adults miR-31 knockout rats Lilianne R. Mujica-Parodi, Anar Amgalan, Syed Fahad Louise Y. Fong, Cristian Taccioli, Alexey Palamarchuk, Sultan, Botond Antal, Xiaofei Sun, Steven Skiena, Guidantonio Malagoli Tagliazucchi, Ruiyan Jing, Karl J. Andrew Lithen, Noor Adra, Eva-Maria Ratai, Corey Smalley, Sili Fan, Joseph Altemus, Oliver Fiehn, Kay Huebner, Weistuch, Sindhuja Tirumalai Govindarajan, Helmut H. Strey, John L. Farber, and Carlo M. Croce Ken A. Dill, Steven M. Stufflebeam, Richard L. Veech, and Kieran Clarke 6086 Immunotoxin SS1P is rapidly removed by proximal tubule cells of kidney, whose damage contributes 6178 Context-dependent operation of neural circuits to albumin loss in urine underlies a navigation behavior in Xui-Fen Liu, Junxia Wei, Qi Zhou, Bruce A. Molitoris, Ruben Caenorhabditis elegans Sandoval, Hisataka Kobayashi, Ryuhei Okada, Tadanobu Muneki Ikeda, Shunji Nakano, Andrew C. Giles, Nagaya, Baktiar Karim, Donna Butcher, and Ira Pastan Linghuan Xu, Wagner Steuer Costa, Alexander Gottschalk, and Ikue Mori 6092 Regulation of B cell receptor-dependent NF-κB signaling by the tumor suppressor KLHL14 6189 Nf1 deletion results in depletion of the Lhx6 transcription factor and a specific loss of Jaewoo Choi, James D. Phelan, George W. Wright, Bjo¨rn + Ha¨upl, Da Wei Huang, Arthur L. Shaffer III, Ryan M. Young, parvalbumin cortical interneurons Zhuo Wang, Hong Zhao, Xin Yu, Thomas Oellerich, Kartik Angara, Emily Ling-Lin Pai, Stephanie M. Bilinovich, and Louis M. Staudt April M. Stafford, Julie T. Nguyen, Katie X. Li, Anirban Paul, John L. Rubenstein, and Daniel Vogt 6103 A hepatocyte differentiation model reveals two subtypes of liver cancer with different oncofetal 6196 Anterior cingulate cortex is necessary for adaptation properties and therapeutic targets of action plans Ming Liu, Qian Yan, Yi Sun, Yoonhee Nam, Liang Hu, Jane HC Adam T. Brockett, Stephen S. Tennyson, Coreylyn A. Loong, Qi Ouyang, Yu Zhang, Hao-Long Li, Fan-En Kong, Lei deBettencourt, Fatou Gaye, and Matthew R. Roesch Li, Yan Li, Mei-Mei Li, Wei Cheng, Ling-Xi Jiang, Shuo Fang, Xiao-Dong Yang, Jia-Qiang Mo, Yuan-Feng Gong, Yun-Qiang Tang, Yan Li, Yun-Fei Yuan, Ning-Fang Ma, Ge Lin, Stephanie PLANT BIOLOGY Ma, Ji-Guang Wang, and Xin-Yuan Guan 6205 CUL3BPM E3 ubiquitin ligases regulate MYC2, MYC3, and MYC4 stability and JA responses MICROBIOLOGY Jose Manuel Chico, Esther Lechner, Gemma 6114 Biphasic chemotaxis of Escherichia coli to the Fernandez-Barbero, Esther Canibano, Gloria Garcı´a-Casado, microbiota metabolite indole Jose Manuel Franco-Zorrilla, Philippe Hammann, Angel M. Jingyun Yang, Ravi Chawla, Kathy Y. Rhee, Rachit Gupta, Zamarren˜o, Jose M. Garcı´a-Mina, Vicente Rubio, Pascal Michael D. Manson, Arul Jayaraman, and Pushkar P. Lele Genschik, and Roberto Solano 6121 Cell-penetrating peptide inhibits retromer-mediated 6216 Triacylglycerol and phytyl ester synthesis in human papillomavirus trafficking during virus entry Synechocystis sp. PCC6803 Pengwei Zhang, Ruben Moreno, Paul F. Lambert, Mohammed Aizouq, Helga Peisker, Katharina Gutbrod, and Daniel DiMaio Michael Melzer, Georg Ho¨lzl, and Peter Do¨rmann 6129 Class A PBPs have a distinct and unique role in the 6223 Carbon export from leaves is controlled via construction of the pneumococcal cell wall ubiquitination and phosphorylation of Daniel Straume, Katarzyna Wiaroslawa Piechowiak, Silje Olsen, sucrose transporter SUC2 Gro Anita Stamsa˚s, Kari Helene Berg, Morten Kjos, Maria Qiyu Xu, Shijiao Yin, Yue Ma, Min Song, Yingjie Victoria Heggenhougen, Martı´n Alcorlo, Juan A. Hermoso, Song, Shuaicheng Mu, Yunsong Li, Xiaohui and Leiv Sigve Ha˚varstein Liu, Yunjuan Ren, Chen Gao, Shaolin Chen, 6139 Structural elucidation of the Clostridioides difficile and Johannes Liesche transferase toxin reveals a single-site binding 6231 Transcriptional repression specifies the central cell mode for the enzyme for double fertilization Michael J. Sheedlo, David M. Anderson, Audrey K. Thomas, Meng-Xia Zhang, Shan-Shan Zhu, Yong-Chao Xu, Ya-Long and D. Borden Lacy Guo, Wei-Cai Yang, and Hong-Ju Li 6145 Visualizing the translation and packaging of HIV-1 6237 Regulation of stomatal development by stomatal full-length RNA lineage miRNAs Jianbo Chen, Yang Liu, Bin Wu, Olga A. Nikolaitchik, Preeti R. Jiali Zhu, Ji-Hwan Park, Seulbee Lee, Jae Ho Lee, Daehee Mohan, Jiji Chen, Vinay K. Pathak, and Wei-Shau Hu Hwang, June M. Kwak, and Yun Ju Kim

Contents PNAS u March 17, 2020 u vol. 117 u no. 11 u vii Downloaded by guest on September 28, 2021 PSYCHOLOGICAL AND COGNITIVE SCIENCES BIOPHYSICS AND COMPUTATIONAL BIOLOGY 6246 Eye movements support behavioral 6275 High-resolution structural insights into the pattern completion heliorhodopsin family Jordana S. Wynn, Jennifer D. Ryan, and Bradley R. Buchsbaum K. Kovalev, D. Volkov, R. Astashkin, A. Alekseev, I. Gushchin, 6255 Speakers are able to categorize vowels based on J. M. Haro-Moreno, I. Chizhov, S. Siletsky, M. Mamedov, A. Rogachev, T. Balandin, V. Borshchevskiy, A. Popov, tongue somatosensation G. Bourenkov, E. Bamberg, F. Rodriguez-Valera, G. Bu¨ldt, Jean-Franc¸ois Patri, David J. Ostry, Julien Diard, Jean-Luc and V. Gordeliy Schwartz, Pamela Trudeau-Fisette, Christophe Savariaux, and Pascal Perrier IMMUNOLOGY AND INFLAMMATION 6276 Phenotypical microRNA screen reveals a noncanonical SYSTEMS BIOLOGY role of CDK2 in regulating neutrophil migration 6264 Metabolic and genetic basis for auxotrophies in Alan Y. Hsu, Decheng Wang, Sheng Liu, Justice Lu, Ramizah Gram-negative species Syahirah, David A. Bennin, Anna Huttenlocher, David M. Umulis, Jun Wan, and Qing Deng Yara Seif, Kumari Sonal Choudhary, Ying Hefner, Amitesh Anand, Laurence Yang, and Bernhard O. Palsson NEUROSCIENCE 6277 Disease onset in X-linked dystonia-parkinsonism CORRECTIONS correlates with expansion of a hexameric repeat within an SVA retrotransposon in TAF1 D. Cristopher Bragg, Kotchaphorn Mangkalaphiban, Christine A. ENGINEERING Vaine, Nichita J. Kulkarni, David Shin, Rachita Yadav, Jyotsna 6274 Deep elastic strain engineering of bandgap through Dhakal, Mai-Linh Ton, Anne Cheng, Christopher T. Russo, Mark machine learning Ang, Patrick Acun˜a, Criscely Go, Taylor N. Franceour, Trisha Zhe Shi, Evgenii Tsymbalov, Ming Dao, Subra Suresh, Multhaupt-Buell, Naoto Ito, Ulrich Mu¨ller, William T. Hendriks, Alexander Shapeev, and Ju Li Xandra O. Breakefield, Nutan Sharma, and Laurie J. Ozelius

viii u www.pnas.org Contents Downloaded by guest on September 28, 2021