Spring/Summer 2012

Forewords from the Head

Spring has flown by and you have all  Faculty & Staff Updates been very busy. We have begun  Awards/Congratulations searches for a number of positions and  Grants I thank all of you who have been so  Testing Services & welcoming to the interviewees. Our Clinical Trial Agreements greatest asset is our people. Really.  Books & Papers  In the News It will be a great time at the End of  Personal News Year Celebration in the Blue  Who Am I Commons, June 14th, noon-2pm. Remember to wear your WolfPack best! You don’t want to miss Steve Marks as the Wolf, Tracy Hill’s personal revelations contest, the random gifts or the staff and graduate student awards. The food is always great (thanks to all of you). So leave those pods in the Terry Center, the Health and Wellness Center, the Barn and the Research Building and come on over as we end another successful year. If you want to see what you might miss if you don’t make it, here is the link to last year’s festivities: http://www.cvm.ncsu.edu/docs/secure/documents/docs_year_end_party_2011.pdf

Some big spring events: Dentistry has moved into their new digs (great color!) and the Exotics Service has opened for business in their new area. The clinical skills lab is full of dust and wet concrete as the renovations proceed. Hopefully the noise has not affected Equine too terribly. The Open House was a huge success thanks to all your efforts. A big hat’s off to Rita Hanel, who worked tirelessly to pull it off. We said goodbye (sort of, he keeps re-appearing) to Shane Christian. (http://www.cvm.ncsu.edu/docs/secure/social_events.html). Nancy Monteiro will be moving to Kansas State this summer and Richard McMullen will be moving back to Germany this fall. We will miss them. – Lizette Hardie

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Faculty & Staff Updates

 Dr. Petra Bizikova will be joining us as an Assistant Professor of Dermatology, effective July 1, 2012. (finalized PhD thesis in May)  Dr. Vanessa Grunkemeyer moved into a Clinical Veterinarian position April 2012, Exotics Service (Degernes/Flammer)  Dr. Seunggon Lee joined Cardiology as a Postdoc on April 1, 2012. (Atkins)

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 Dr. Patricia Mascarelli moved into a Research Associate position February 2012, Small Animal Internal Medicine Service. (Breitschwerdt)  Dr. Richard McMullen will be leaving us in November to move back to Germany.  Dr. Meghali Nighot moved into a Postdoc position March 26, 2012, with Equine (Blikslager).  Dr. Barbara Qurollo joined Small Animal Internal Medicine as a Postdoc on February 3, 2012. (Breitschwerdt)  Dr. Nancy Riviere-Monteiro will be leaving us the end of July. She will serve as a Regents Distinguished Research Scholar and University Distinguished professor in the Department of Anatomy and Physiology in the College of Veterinary Medicine at Kansas State University. We are having a farewell reception on July 20, 2-4 pm in the Green Commons.  Stephen Stauffer moved into a Research Assistant position June 1, 2012, with Small Animal Internal Medicine. (Gookin) (former SPA employee)  Dr. Ganokon Urkasemsin moved into a Postdoc position May 14, 2012, with Neurology. (Olby)

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Awards/Congratulations Javier Benito, Postdoctoral Research Scholar, received a recognition award for the poster (December 2011-May 2012) presentation entitled “Evaluation of Meloxicam Dr. Adam Birkenheuer is the recipient of a and Tepoxalin in Cats. “ (Advisor: Duncan grant from Morris Animal Foundation to support Lascelles) his ongoing research into Cytauxzoonosis, March 2012. Dr. Duncan Lascelles received the Pfizer Animal Health Award for Research Excellence DoCS was a part of 2 successful Chancellor’s at the CVM Awards Banquet, April 26, 2012. Faculty Excellence Proposals: Dr. Greg Lewbart received the William 1) Positioning NC State as a Global Leader in rd Methodology for Personalized Medicine Medway Award for Excellence at the 43 Discovery. The following members had input: Annual Meeting of the International Association Anthony Blikslager, Kim Chappell, Bruce for Aquatic Animal Medicine held in Atlanta, Keene, Duncan Lascelles, Natasha Olby, GA, May 12-16, 2012. Thierry Olivry, Steven Suter, and Michael The CVM Awards Banquet was held on Wood. th 2)Translational Regenerative Medicine Initiative April 26 , the following received awards: – From Bench to Clinics. Dr. Kyle Mathews Fonda Martin and Gail Druley - Phyllis was one of the authors of the proposal. Edwards Service Award Dr. Kieri Jermyn - Class of 2012 Small Animal Dr. David Bristol named American Council on Clinician Award Education Fellow for 2012-2013. Dr. Steve Marks - Class of 2013 Bayer Faculty Award Dr. Ed Breitschwerdt won an Alumni Association Outstanding Research Award. The Promotions effective July 1, 2012: official announcement was made at Dr. Rita Hanel – Clinical Associate Professor Commencement. Dr. Marlene Hauck – Professor Dr. William Krug – Clinical Associate Gail Druley and Henry Marr received CVM Professor Awards for Excellence, May 15, 2012. Dr. Ricardo Maggi – Research Associate Professor Dr. Sam Jones was appointed to the Herbert Dr. Laurel Williams – Professor Benjamin Distinguished professorship, May Dr. Barbara Sherman – Clinical Professor 2012. Dr. Steven Suter – Associate Professor

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Grants Received Hauck M. Targeting the metastatic phenotype (December 2011-May 2012) in canine soft tissue sarcoma cell lines. Morris Animal Foundation, $4,000. Bailey C, Lewbart G. Semen collection, evaluation, and cryopreservation in Tarantulas. Jones S, Adler K. Targeting neutrophil 06/01/12-10/01/12 (Triangle Community activation to develop novel drugs to treat Foundation) $5,000. inflammation in horses. Morris Animal Foundation, $49,113. Birkenheuer A, Bird D, Levy M. Prevention of Cytauxzoon Felis infections in domestic cats. Lascelles D. Influence of an intramedullary pin ALSAM Foundation, $50,000. on the stability of a feline ilial fracture stabilized with a bone plate. American College of Blikslager A. Does large colon resection and Veterinary Surgeons, $6,572. anastomosis affect survival in horses with large colon volvulus. NC Horse Council, $4,154. Olby N. Role of morphology in clinical progression and syringomyelia in Cavalier King Chappell K, Hauck M. Multicenter non- Charles Spaniel chiari-like malformation. controlled pilot field study to assess the Cornell University (American Cavalier King maximum tolerated dose and efficacy of Bgt226 Charles Spaniel Club Charitable Trust, Inc.), tablets when administered for up to 4 weeks in $18,662. treatment cohorts of increasing doses to client- owned dogs with B-cell lymphoma. Novartis Olivry T, Linder K. Validation of an epicutaneos Animal Health Inc., $178,090. delivery system for mite allergy diagnosis in experimentally sensitized mite-allergic dogs. Fish R. Umbilical cord mesenchymal stem cell (DBV-Technologies, Paris, France) $33,115. treatment for a swine alveolar cleft model. UNC Chapel Hill, $11,585. Suter S, Hanel R, Istvan S. The effect of platelet products on hemostasis in dogs after Gookin J, Jones S, Meurs K. Dorman D. irradiation inducted thrombocytopenia. NCSU Merial Veterinary Scholars Program. Merial Veterinary Medical Foundation, $6,000. Limited, $20,000. Suter S. The effect of varying storage Hanel R, Istvan S, Suter S. The effect of conditions on CD34+ peripheral blood platelet-containing products on hemostasis in progenitor cell viability. NC Veterinary Medical dogs after total body irradiation induced Foundation, Inc., $2,000. thrombocytopenia. NCSU Veterinary Medical Foundation (Firestone Canine Research Vaden S. Improving outcome in dogs with Foundation), $3,000. glomerular disease via pharmacodynamic- based dosing of Enapril. Ohio State University Harms C, Papich M, Chinnadurai S. Sex (Morris Animal Foundation), $21,448. differences in meloxicam pharmacokinetics in ferrts after single subcutaneous and oral ______administration. Association of Exotic Mammal Veterinarians, $5,000. Testing Service and Clinical Trial Agreements Harms C. Collaborative development of (December 2011-May 2012) stranded cetacean euthanasia recommendations. Virginia Aquarium & Marine Gilger BC. Evaluation of a topical eyedrop in Science Center Foundation (National Oceanic an acute model of allergic conjunctivitis in & Atmospheric Administration (NOAA), $7,500. guinea pigs. C.T. Development Switzerland

SARL, $18,938. Hauck M. Targeting metastatic pathways. Triangle Community Foundation, $5,000. 3

Gilger BC. Testing of device on a porcine Bailey CS. Ovarian remnant syndrome – a model of uveitis. Clearside BioMedical, Inc., diagnostic dilemma. Clin Therio 2011;3(3):192- $19,268. 195.

Gilger BC. Evaluation of a subconjunctival Bailey CS. Pregnancy termination in cyclosporine compound for long-term treatment companion animals. Clin Therio 2011;3(3):196- of dogs with naturally occurring 199. keratoconjunctivitis sicca (KCS). Auritec Pharmaceuticals Inc., $6,000. Pozor MA, Muehlhaus J, King A, Macpherson ML, Troedsson MH, Bailey CS. Effect of Gilger BC. Drug testing on animal model of pentoxifylline treatment on testicular perfusion keratitis. C.T. Development Switzerland SARL, and semen quality in Miniature horse stallions. $23,000. Theriogenology 2011;76(6):1027-1035.

______Holowaychuk MK, Birkenheuer AJ, Li J, Marr H, Boll A, Nordone SK. Hypocalcemia and Books and Papers Published hypovitaminosis d in dogs with induced (December 2011-May 2012) endotoxemia. J Vet Intern Med. 2012 Mar;26(2):244-51. Lantis AC, Atkins CE, DeFrancesco TC, Keene BW, Weere SR. Effects of furosemide Li J, Birkenheuer AJ, Marr HS, Levy MG, and the combination of furosemide and the Yoder JA, Nordone SK. Expression and labeled dosage of pimobendan on the function of triggering receptor expressed on circulating renin-angiotensin-aldosterone myeloid cells-1 (TREM-1) on canine system in clinically normal dogs. Am J Vet Res neutrophils. Dev Comp Immunol 2011;72:1646-1651. 2011;35(8):872-880.

Atkins CE. Finding a consensus on canine Birkenheuer AJ. Babesiosis. . In: Tilley LP, Smith FWK, eds. Blackwell’s Five Minute CVHD, Clinician’s Brief, 2011;9:53-57. th Veterinary Consult, 5 ed. Ames:Wiley- Meurs KM, Heaney AM, Atkins CE, Blackwell, 2011. DeFrancesco TC, Fox PR, Keene BW, Kellihan HB, Miller MW, Oyama MA, Oaks JL. Meyerhoff RR, Nighot PK, Ali RA, Blikslager Comparison of polymerase chain reaction with AT, Koci MD. Characterization of turkey bacterial 16s primers to blood culture to identify inducible nitric oxide synthase and identification bacteremia in dogs with suspected bacterial of its expression in the intestinal epithelium endocarditis. J Vet Intern Med 2011;25:955- following astrovirus infection. Comp Immunol 962. Microbiol Infect Dis 2012;35:63-69.

Atkins CE, Haggstrom J. Pharmacologic Nighot PK, Blikslager AT. The chloride management of myxomatous mitral valvular channel ClC-2 modulates tight junction barrier disease in dogs. J Vet Cardiol Special Issue, function via intracellular trafficking of occludin. 2012;14(1):165-184. Am J Physiol Cell Physiol 2012;302:C178-187. (featured on Journal cover). Bailey CS, Sper RB, Schewmaker JL, Buchanan CN, Beachler TM, Pozor MA, Blikslager AT, Marshall JM. Principles of Whitacre MD. Uterine artery blood flow intestinal injury and determination of intestinal remains unchanged in pregnant mares in viability. In: Auer JA, Stick JA, eds. Equine response to short-term administration of Surgery. Missouri: Saunders Elsevier, 2012; pentoxifylline. Theriogenology 2012;77(2):430- 411-415. 436.

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Marshall JM, Blikslager AT. Colic: Diagnosis, Breuhaus BA. Endocrine system. In: Munroe surgical decision, and preoperative GA, Weese JS, eds. Equine Clinical Medicine, management. In: Auer JA, Stick JA, eds. Surgery, and Reproduction. London, UK: Equine Surgery. Missouri: Saunders Elsevier, Manson Publishing, Ltd., 2011; 620-636. 2012; 402-406. Alcott CJ, Wong DM, Sponseller BA, Davis JL, Wilson DA, Blikslager AT. Stomach and Hsu W, Wang C. The clinical and spleen. In: Auer JA, Stick JA, eds. Equine immunomodulating effects of a ketamine Surgery. Missouri: Saunders Elsevier, 2012; continuous rate infusion in horses with 388-401. experimental endotoxemia. J Vet Intern Med 2011;25(4):934-943. VanderHeyden TR, Yong SL, Breitschwerdt EB, Maggi RG, Parada JP, Mihalik AR, Fimmel Messenger KM, Davis JL, LaFevers DH, CJ. Granulomatous hepatitis due to Bartonella Barlow BM, Posner LP. Intravenous and henselae infection in an immunocompetent sublingual buprenorphine in horses: patient. BMC Infect Dis 2012;12:17. Pharmacokinetics and influence of sampling site. Vet Anesth Analg 2011;38(4):374-384. Vanderheyden TR, Fimmel CJ, Yong SL, Breitschwerdt EB, Parada JP, Mihalik AR, Davis JL, Messenger KM, LaFevers DH, Maggi RG. Granulomatous hepatitis due to Barlow BM, Posner LP. Pharmacokinetics of Bartonella henselae infection in an intravenous and intramuscular buprenorphine in immunocompetent patient. BMC Infect horses. J Vet Pharmacol Ther 2011;35(1):52- 2012;12:17. 58.

Billeter SA, Kasten RW, Killmaster LF, Wearn JMG, Crisman MV, Davis JL, Geor RJ, Breitschwerdt EB, Levin ML, Levy MG, Kosoy Hodgson DR, Suagee JK, Ashraf-Khorassani MY, Chomel BB. Experimental infection by M, McCutcheon J. Pharmacokinetics of capillary tube feeding of Rhipicephalus pioglitazone in horses after multiple dose oral sanguineus with Bartonella vinsonii subspecies administration. J Vet Pharmacol Ther berkhoffii. Comp Immunol Microbiol Infect Dis. 2011;34(3):252-258. 2012;35:9-15. Tou SE, DeFrancesco TC, Keene BW. ECG of Billeter SA, Breitschwerdt EB, Levy MG. the Month. Intermittent tachycardia-dependent Invasion of canine erythrocytes by Bartonella left bundle branch block in a dog during vinsonii subsp. berkhoffii. Vet Microbiol anesthesia. J Am Vet Assoc 2011;239:55-57. 2012;156:213-216. Hofer J, DeFrancesco TC, Williams LE. Weese JS, Blondeau JM, Boothe D, Detection of tumor necrosis factor alpha (TNF- Breitschwerdt EB, Guardabassi L, Hillier A, α) in dogs with lymphoma. Vet Comp Oncol Lloyd DH, Papich MG, Rankin SC, Turnidge JD, 2011;9:290-295. Sykes JE. Antimicrobial use guidelines for treatment of urinary tract disease in dogs and Fox PR, Rush JE, Reynolds CA, cats: antimicrobial guidelines working group of DeFrancescoTC, Keene BW, Atkins CE, the International Society for Companion Animal Gordon SG, Schober KE, Bonagura JD, Infectious Diseases. Vet Med Int Stepien RL, Kellihan HB, Macdonald KA, 2011;2011:263768. Lehmkuhl LB, Nguyenba TC, Syndey Moise N, Lefbom BK, Oyama MA. Multicenter evaluation Ayllón T, Diniz PPVP, Breitschwerdt EB, of plasma N-terminal probrain natriuretic Villaescusa A, Rodríguez-Franco F, Sainz A. peptide (NTproBNP) as a biochemical Vector borne diseases in client-owned and screening test for asympatomatic (occult) stray cats from Madrid, Spain. Vector Borne cardiomyopathy in cats. J Vet Intern Med Zoonotic Dis 2011;12(2):143-150. 2011;25:1010-1016.

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Dixon PM, Gerard MP. Oral cavity and salivary Azcarate-Peril MA, Foster DM, Cadenas MB, glands. In: Auer J, Stick J, eds. Equine Stone MR, Jacobi SK, Stauffer SH, Pease A, Surgery, 4th Edition. Saunders-Elsevier: St Gookin JL*. Acute necrotizing enterocolitis of Louis, 2012; 339-367. preterm piglets is characterized by dysbiosis of ileal mucosa-associated bacteria. Gut Microbes Gerard MP. Nasal/paranasal neoplasia. In: 2011;2:234-243. (*Corresponding and primary Wilson DA, ed. Clinical Veterinary Advisor, The author). This article was featured on the cover Horse. Saunders/Elsevier, St Louis: Missouri, of the Journal. 2012; 395-396. Conner BJ, Hanel RM, Hansen BD*, Gerard MP. Nasal polyps. In: Wilson DA, ed. Motsinger-Reif A, Asakawa M, Swanson CR. Clinical Veterinary Advisor, The Horse. The effects of acepromazine on platelet Saunders/Elsevier: St Louis, Missouri, 2012; function assessed by adenosine diposphate- 375-376. and arachidonic acid-activated modified thromboelastography in healthy dogs. Am J Vet Sommer JR, Estrada JL, Collins EB, Bedell M, Res 2012;73:595-601. (*Corresponding author, Alexander CA, Yang Z, Hughes G, Mir B, first author trainee) Gilger BC, Grob S, Wei X, Piedrahita JA, Shaw PX, Petters RM, Zhang K. Production of Harms CA, Harms RV. Venous blood gas and ELOVL4 transgenic pigs: a large animal model lactate values of mourning doves (Zenaida for Stargardt-like macular degeneration. Br J macroura), boat-tailed grackles (Quiscalus Ophthalmol 2011;95(12):1749-1754. major) and house sparrows (Passer domesticus) following capture by mist net, Seiler GS, Salmon JH, Mantua R, Feingold S, banding, and venipuncture. J Zoo Wildl Med Dayton PA, Gilger BC. Distribution of contrast 2012;43:83-90. after injection into the anterior suprachoroidal space using 2D and 3D ultrasound in pig eyes. Boylan SM, Harms CA, Waltzek T, Law JM, Invest Ophthalmol Vis Sci 2011;52(8):5730- Garner M, Cassell J, Fatzinger MH, Govett P. 5736. Hyperplastic adipose lids in mackerel scad (Decapterus macarellus). J Fish Dis Gilger BC. Clinical commentary: Challenges in 2011;34:921-925. the treatment of equine periocular squamous cell carcinoma. Equine Vet Educ Harms CA, Lewbart GA. The veterinarian’s 2011;23(10):500-501. role in surgical implantation of electronic tags in fish. Rev Fish Biol Fisheries 2011;21:25-33. Gilger BC. Concerns with analysis of correlated eye data. Vet Ophthalmol 2011;14(3):214 Anderson ET, Harms CA*, Stringer EM, Cluse Editorial. WM. Evaluation of hematology and serum biochemistry of cold-stunned green sea turtles Pate DO, Gilger BC, Suter SE, Clode AB. (Chelonia mydas) in North Carolina. J Zoo Diagnosis of intraocular lymphosarcoma in a Wildl Med 2011;42:247-255. (*Corresponding dog by use of a polymerase chain reaction author) assay for antigen receptor rearrangement. J Am Vet Med Assoc 2011;238(5):625-630. Anderson ET, Minter LJ, Clarke EO, Mroch RM, Beasley JF, Harms CA*. The effects of Tolbert MK, Leutenegger CM, Lobetti R, Birrell feeding on hematological and plasma J, Gookin JL*. Species identification of biochemical profiles in green (Chelonia mydas) trichomonads and associated coinfections in and Kemp’s ridley (Lepidochelys kempii) sea dogs with diarrhea and suspected turtles. Vet Med Int. 2011; 7 pp/ trichomonosis. Vet Parasitol 2012;187(1-2):319- DOI:10.4061/2011/890829 http://www.sage- 22. (*Corresponding author, first author hindawi.com/journals/vmi/aip/890829/ graduate student) (*corresponding author)

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Stringer EM, Harms CA*, Beasley JF, Ott LE, McDowell ZT, Turner PM, Law JM, Anderson ET. Comparison of ionized calcium, Adler KB, Yoder JA, Jones SL. Two parathyroid hormone, and 25-hydroxyvitamin D myristoylated alanine-rich C-kinase substrate in rehabilitating and healthy wild green sea (MARCKS) paralogs are required for normal turtles (Chelonia mydas). J Herp Med Surg development in zebrafish. Anatomical Rec 2010;20:122-127. (*corresponding author; 2011;294:1511–1524. despite indicated year, this issue did not come out until January 2012) Kornegay JN, Bogan JR, Bogan DJ, Childers MK, Li J, Nghiem P, Detwiler DA, Larsen CA, Piniak WED, Mann DA, Eckert SA, Harms CA. Grange RW, Bhavaraju-Sanka RK, Tou SP, Amphibious hearing in sea turtles. In: Popper Keene BW, Howard Jr JF, Wang J, Fan Z, AN, Hawkins A, eds. The Effects of Noise on Schatzberg SJ, Styner MA, Flanigan KM, Xiao Aquatic Life, Advances in Experimental X, Hoffman EP: Canine models of Duchenne Medicine and Biology. Springer muscular dystrophy and their use in therapeutic Science+Business Media, 2012;730:83–87. strategies. Mamm Genome 2012;23(1-2):85- 108. Harms CA. Echinoderms. In: Lewbart GA, ed. Invertebrate Medicine, 2nd Edition. Ames, Iowa: Tou SP, Barker PCA, Keene BW. Pulmonary Wiley-Blackwell, 2012; 365–379. atresia and ventricular septal defect with aorticopulmonary collaterals in an adult dog. J Boyle TE, Hawkins EC*, Davis JL, Robertson Vet Cardiol 2011;13(4):271-275. ID. Failure of nebulized irritant, acidic, or hypotonic solutions or external mechanical Thakur S, Sandfoss MR, Kennedy-Stoskopf S, stimulation of the trachea to consistently induce Deperno CS. Detection of Clostridium dificile coughing in healthy, awake dogs. Can J Vet and Salmonella in feral pigs in North Carolina: Res 2011;75:228-232. (*corresponding author) Implications and potential for horizontal transmission. J Wildl. Dis 2011;47(3):774-776. Hawkins EC. Pneumonia, aspiration. In: Tilley LP, Smith FWK, eds. Blackwell’s Five Minute Sandfoss MR, DePerno CS, Betsill CW, Veterinary Consult, 5th ed. Ames:Wiley- Erickson G, Kennedy-Stoskopf S. A Blackwell, 2011; 1001. serosurvey of Brucella suis, classical swine fever, porcine circovirus type 2, and Grosenbaugh DA, Leard T, Bergman PJ, Klein pseudorabies in feral pigs (Sus scrofa) of MK, Meleo K, Susaneck S, Hess PR, eastern North Carolina. J Wildl Dis Jankowski MK, Jones PD, Leibman NF, 2012;48(2):462-466. Johnson MH, Kurzman ID, Wolchok JD. Multicenter clinical trial with a xenogeneic DNA Avery S, Krug W, Stoskopf M, Heatwole H. vaccine administered as an adjunct treatment Venom canal occlusion as an experimental for canine oral malignant melanoma following alternative to surgical ly-rendered venomoid surgical excision of the primary tumor. Am J Vet snakes in the copperhead, Agkistrodon Res 2011;72(12):1631-1638. contortrix. Herpetol Rev 2011;42(1):49-50.

Szabo SD, Jermyn K, Neel J, Mathews KG. Lascelles BDX, Dong Y, Marcellin-Little DJ, Evaluation of postceliotomy peritoneal drain Thomson A, Wheeler S, Correa M. Relationship fluid volume, cytology and blood-to-peritoneal of orthopedic examination, goniometric fluid lactate and glucose differences in normal measurements, and radiographic signs of dogs. Vet Surg 2011;40(4):444-449. degenerative joint disease in cats. BMC Veterinary Research 2012;8:10. Jermyn K, Roe SC. Influence of screw insertion order on compression generated by Lewbart GA. (ed). Invertebrate Medicine, 2nd bone plates in a fracture model. Vet Comp Ed. Oxford, UK: Wiley-Blackwell Publishing, Orthop Traumatol 2011;24(6):403-407. 2012, 488 pp.

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Ardente AJ, Christian LS, Borst LB, Lewbart Varanat M, Maggi RG, Linder KE, GA*. Clinical Challenge: Mistaken identity of a Breitschwerdt EB*. Molecular prevalence of squamous cell carcinoma in a captive red-eared Bartonella, Babesia and hemotropic slider turtle, Trachemys scripta elegans. J Zoo Mycoplasma sp. in dogs with splenic disease. Wildl Med 2012;42(4):770-773. (*corresponding JVIM 2011;25:1284–1291. (*corresponding author) author, first author trainee)

Lewbart GA., Mosley C. Clinical anaesthesia Cherry NA, Maggi RG, Rossmeisl JH, Hegarty and analgesia in invertebrates. J Exotic Pet BC, Breitschwerdt EB*. Ecological diversity of Med 2012;21:59-70. Bartonella Species infection among dogs and their owner in Virginia. Vector Borne Zoonotic Minter LJ, Clarke 3rd EO, Gjeltema JL, Dis 2011;11:1425-1432. (*corresponding Archibald KE, Posner LP, Lewbart GA. Effects author, first author trainee) of intramuscular meloxicam administration on prostaglandin e2 synthesis in the North Maggi RG, Mozayeni R, Pultorak EL, Hegarty American bullfrog Rana catesbeiana. J Zoo BC, Bradley JM, Correa M, Breitschwerdt EB. Wildl Med 2011;42(4):680-685. Bartonella spp. bacteremia in high-risk patients. Diagn Microbiol Infect Dis. 2011;71:430-437. Lewbart GA. Introduction. In: Lewbart GA, ed. Invertebrate Medicine, 2nd Edition. Oxford, UK: Maggi R, Kempf VA, Chomel BB, Wiley-Blackwell Publishing, 2012; 3-6. Breitschwerdt EB. Bartonella. In: Versalovic J (ed). Manual of Clinical Microbiology, 10th Lewbart GA. Sponges. In: Lewbart GA,ed. Edition. American Society for Microbiology, Invertebrate Medicine, 2nd Edition. Oxford, UK: 2011; Chapter 46. Wiley-Blackwell Publishing, 2012; 7-20. Maggi RG. Bartonella vinsonii berkhoffii: Un Lewbart GA. Annelids. In: Lewbart GA, ed. patógeno zoonótico compartido por perros y Invertebrate Medicine, 2nd Edition. Oxford, UK: humanos. Book chapter: Zoonosis 5. 2012. Wiley-Blackwell Publishing, 2012; 173-185. Spanish.

Lewbart GA. Reportable Diseases of Little JP, Horn TJ, Marcellin-Little DJ, Invertebrates. In: Lewbart GA, ed. Invertebrate Harrysson OLA, West II HA. Development and Medicine, 2nd Edition. Oxford, UK: Wiley- validation of a canine radius replica for Blackwell Publishing, 2012; 471-472. mechanical testing of orthopedic implants. Am J Vet Res 2012;73:27–33. Berzins IK, Smolowitz, RM, Lewbart GA. Diagnostic Techniques and Sample Handling. McCulloch R, Mente P, Marcellin-Little D, Roe In: Lewbart GA, ed. Invertebrate Medicine, 2nd SC. Resistance to subsidence of an Edition. Oxford, UK: Wiley-Blackwell Publishing, uncemented femoral stem after cerclage wiring 2012; 389-400. of a fissure, Vet Surg 2011;41:163–167.

Bakal RS, Lewbart GA. Urochordates In: Marks SL. Clostridial Diarrhea. In: Cote E ed. Lewbart GA, ed. Invertebrate Medicine, 2nd Clinical Veterinary Advisor: Dogs and Cats. St. Edition. Oxford, UK: Wiley-Blackwell Publishing, Louis: Mosby Elsevier, 2012; 381-388. www.clinicalvetadvisor2.com 2011.

Maggi RG, Harms CA, Breitschwerdt EB. Marks SL. Spirocerca Lupi. In: Cote E ed. Bartonellosis: an emerging disease of humans, Clinical Veterinary Advisor: Dogs and Cats. St. domestic animals, and wildlife. In: Aguirree AA, Louis: Mosby Elsevier, Ostfeld RS, Daszak P (eds). Conservation www.clinicalvetadvisor2.com 2011. Medicine: Applied Cases of Ecological Health. New York: Oxford University Press, 2012, 239- 256. 8

Marks SL. Electric Cord Bite Injury. In: Tilley Narayan RJ, Boehm RD, Monteiro-Riviere NA. LP, Smith FWK, eds. Blackwell’s Five Minute Cell and Protein Interactions with Small-Scale Veterinary Consult. Oxford: Blackwell Diamond Materials. In Bronzino JD, Bawa R, Publishing, 2011; 409. eds. The Biomedical Engineering Handbook- Nanomedicine. New York: CRC Press/Taylor Marks SL. Cardiopulmonary Arrest. . In: Tilley Francis 2011;Vol.4. LP, Smith FWK, eds. Blackwell’s Five Minute Veterinary Consult. Oxford: Blackwell Monteiro-Riviere NA, Larese Filon F. Effects Publishing, 2011;222-223. of Engineered Nanomaterials on Skin. In: Fadeel B, Pietroiusti A, Shvedova A, eds. Marks SL. Heat Stroke. In: Tilley LP, Smith Adverse Effects of Engineered Nanomaterials. FWK, eds. Blackwell’s Five Minute Veterinary New York: Elsevier, 2012; Chapter 11, 185- Consult. Oxford: Blackwell Publishing, 2011; 207. 537-538. Muñana KR, Thomas WB, Inzana KD, Mathews KG. Ureteral Surgery. In: Tobias KM, Nettifee-Osborne JA, McLucas KJ, Olby NJ, Johnston SA, eds. Veterinary Surgery Small Mariani CM, Early PJ. Evaluation of Animal. St Louis: Elsevier, 2012, 1962-1977. levetiracetam as adjunctive treatment for refractory canine epilepsy: A randomized, Mathews KG. Tonsillectomy; Correction of placebo-controlled, cross-over trial. J Vet Intern overlong soft palate; Oral approaches to the Med 2012;26:341-348. nasal cavity and nasopharynx. In: Verstraete FJM, Lommer MJ, eds. Oral and maxillofacial Muñana KR. Feline Hyperesthesia Syndrome. surgery in dogs and cats. WB Philadelphia: In: Tilley LP, Smith FWK (eds). Blackwell’s Saunders, 2012;539-542,547-556. Five-Minute Veterinary Consult, Canine and Feline, 5th Edition. Philadelphia: Lippincott Monteiro-Riviere NA (ed). Nanotoxicology: Williams & Wilkins, Philadelphia, 2011; pp 463. Progress Toward Nanomedicine. Informa Healthcare, New York, NY, August 2012. Muñana KR. Nystagmus. In: Tilley LP, Smith FWK (eds). Blackwell’s Five-Minute Veterinary Prow TW, Monteiro-Riviere NA, Inman AO. Consult, Canine and Feline, 5th Edition. Grice JE, Chen X, Zhao X, Sanchez WH, Philadelphia: Lippincott Williams & Wilkins, Gierden A, Kendall MA, Zvyagin AV, Erdmann Philadelphia, 2011; 897-898. D, Riviere JE, Roberts MS. Quantum dot penetration into viable human skin. Muguet-Chanoit AC, Olby NJ, Babb K, Lim J-H, Nanotoxicology 2012;6:173-185. Gallagher R, Niman Z, Dillard S, Campbell J, The sensory field and repeatability of the Samberg ME, Orndorff PE, Monteiro-Riviere cutaneous trunci muscle reflex in the dog. Vet NA. Antibacterial efficacy of silver Surg 2011:40;781-785. nanoparticles of different sizes, surface conditions and synthesis methods. Olby NJ. Hypermetria and dysmetria. In: Tilley Nanotoxicology 2011;5(2):244-253. LP, Smith FWK, eds. Blackwell’s Five Minute Veterinary Consult: Canine & Feline, Fifth Monteiro-Riviere NA. Commentary on Edition. Wiley Blackwell, 2011; 624-625. transcutaneous delivery. WIREs Nanomedicine and Nanobiotechnology 2011;3:439-440. Olby NJ. Head pressing. In: Tilley LP, Smith FWK, eds. Blackwell’s Five Minute Veterinary Boehm RD, Miller PR, Hayes SL, Monteiro- Consult: Canine & Feline, Fifth Edition. Wiley Riviere NA, Narayan RJ. Modification of Blackwell, 2011; 530-531. microneedles using inkjet printing. AIP Advances 2011;1(2):22139. Olby NJ. Subarachnoid cysts. In: Tilley LP, Smith FWK, eds. Blackwell’s Five Minute

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Veterinary Consult: Canine & Feline, Fifth Johnson S, von Peifl DJF, Dejardin L, Weh M, Edition. Wiley Blackwell, 2011; 1205-1206. Roe SC. Internal Fracture Fixation. In: Tobias K, Johnson S, eds. Veterinary Surgery Small Olby NJ, Jeffrey ND. Pathogenesis of Animal. Elsevier, 2012, 576–607. diseases of the central nervous system. In: Tobias and Johnson, eds. Tobias and Johnson: Mansmann RA, Currie MC, Correa MT, Small Animal Surgical Practice. Elsevier, 2011; Sherman BL, vom Orde K. Equine behavior Chapter 29, 374-387. problem around farriery: foot pain in 11 horses. J Vet Sci 2011;31:44-48 (contributed to Olby NJ. Spinal trauma. In: Platt SR, Garosi L, experimental design, production of MS). eds. Small Animal Neurological Emergencies. Manson Publishing Ltd. 2012; Chapter 21. Sherman BL. Housesoiling—Cats. In: Tilley LP, Smith FWK, Eds. Blackwell’s Five-Minute Oberkirchner U, Linder KE, Olivry T. Veterinary Consult: Canine and Feline, Fifth Successful treatment of a novel generalized Edition, Ames IA: Wiley-Blackwell, 2011; 592- variant of canine discoid lupus erythematosus 594. with oral hydroxychloroquine. Veterinary Dermatology 2012;23: 65-e16. (corresponding Sherman BL. Compulsive Disorders—Cats. In: author with resident trainee first author) Tilley LP, Smith FWK, Eds. Blackwell’s Five- Minute Veterinary Consult: Canine and Feline, Favrot C, Steffan J, Seewald W, Hobi S, Linek 5th Edition, Ames IA: Wiley-Blackwell, 2011; M, Marignac G, Olivry T, Beco L, Nett C, 278-280. Fontaine J, Roosje P, Bergvall K, Belova S, Koebrich S, Pin D, Kovalik M, Meury S, Wilhelm Sherman BL. Aggression, Overview—Dogs. In: S. Establishment of diagnostic criteria for feline Tilley LP, Smith FWK, Eds. Blackwell’s Five- nonflea-induced hypersensitivity dermatitis. Vet Minute Veterinary Consult: Canine and Feline, Dermatol 2012;23:45-e11. 5th Edition, Ames IA: Wiley-Blackwell, 2011; 47- 49. Olivry T*, Linder KE*, Wang P*, Bizikova P, Bernstein J, Dunston SM, Paps JS, Casal M. Escobar C, Grindem C, Neel JA, Suter SE. Deficient plakophilin-1 expression due to a Hematologic change after total body irradiation mutation in PKP1 causes ectodermal dysplasia- and autologous transplantation of fragility syndrome in Chesapeake Bay retriever hematopoietic peripheral blood progenitor cells dogs. PLos ONE 2012;7:e32072. (*these in dogs with lymphoma. Vet Pathol authors contributed equally to the work.) 2011;49(2):341-343.

Olivry T. What can dogs bring to atopic Vaden SL. Proteinuria. In: Tilley LP, Smith dermatitis research? Chem Immunol and FWK, eds. Blackwell’s Five Minute Veterinary Allergy 2012;96:61-72. Consult, 5th Edition. Ames:Wiley-Blackwell, 2011; 1150-1151. Hobi S, Linek M, Marignac G, Olivry T, Beco L, Nett C, Fontaine J, Roosje P, Bergvall K, Williams LE. Lymphoma, cutaneous. In Cote Belova S, Koebrich S, Pin D, Kovalik M, Meury E, ed. Clinical Veterinary Advisor, 2nd Edition. S, Wilhelm S, Favrot C. Clinical characteristics St. Louis, MO: Mosby Elsevier; 2011:271. and causes of pruritus in cats: a multicentre study on feline hypersensitivity-associated Williams LE. Lymphoma, cat (multicentric). In dermatoses. Vet Dermatol 2011;22;406-413. Cote E, ed. Clinical Veterinary Advisor, 2nd Edition. St. Louis, MO: Mosby Elsevier; Oberkirchner U, Linder KE, Olivry T*. 2011:669-671. Recognizing and treating Promeris-triggered pemphigus foliaceus in dogs. Vet Med Williams LE. Lymphoma chemotherapy 2011;106:284-293. (*corresponding author, treatment tables, cat. In Cote E, ed. Clinical trainee first author) 10

Veterinary Advisor, 2nd Edition. St. Louis, MO: commented upon the special "Room for Mosby Elsevier; 2011: 673-674. Debate" follow up on April 9th http://www.nytimes.com/roomfordebate/2012/04 Williams LE. Lymphoma, chemotherapy /09/the-ethics-of-spending-25000-on-pet-health- treatment tables, dog. In Cote E, ed. Clinical care Veterinary Advisor, 2nd Edition. St. Louis, MO: Mosby Elsevier; 2011:674-675. Dr. Steven Suter was interviewed by Minnesota Public Radio on canine bone marrow Williams LE. Lymphoma, dog (multicentric). In transplants and cost of specialty health Cote E, ed. Clinical Veterinary Advisor, 2nd care> http://minnesota.publicradio.org/display/w Edition. St. Louis, MO: Mosby Elsevier; 2011: eb/2012/04/19/daily-circuit-saving-your-pet/ 675-678. ______Dr. Mathew Gerard was interviewed by WRAL on March 18th concerning a miniature horse In the News that was brought to the Equine and Large Animal Veterinary Center after being attacked

by an animal or animals. Drs. Gerard and On the Cover: Jennifer Davis handled the emergency. Nighot PK,

Blikslager AT. The Dr. Duncan Lascelles was quoted in an ABC chloride channel News web article on the warning signs of ClC-2 modulates arthritis in pets., March 5th. tight junction barrier

function via Dr. Duncan Lascelles and Dr. Ola Harrysson intracellular from the College of Engineering were trafficking of interviewed about ossseointegrated implant occludin. Am J patient Cyrano during the national NPR Physiol Cell Physiol program “The Animal House.” 2012;302:C178-187.

The CVM was the host institution as the world's On the Cover: Azcarate- top Bartonella for the 7th International Peril MA, Foster DM, Conference on Bartonella as Animal and Cadenas MB, Stone MR, Human Pathogens Jacobi SK, Stauffer SH, http://www.cvm.ncsu.edu/conted/icbmvp7.html Pease A, Gookin JL*. Dr. Ed Breitschwerdt presented and was Acute necrotizing quoted in a Veterinary Practice News article on enterocolitis of preterm the 15 known pathogens that ticks can transmit piglets is characterized by to a dog, March 2012. dysbiosis of ileal mucosa-

associated bacteria. Gut Dr. Thierry Olivry was quoted in Veterinary Microbes 2011;2:234- Practice News on the clinical guidelines he 243. helped develop as the lead author for the

International Task Force on Canine Atopic Dr. Margaret Gruen was the guest on NBC- Dermatitis, March 2012. 17's "My Carolina Today" on May 15, 2012

where she discussed preventing dog bites as Dr. Richard Ford was quoted in a Veterinary part of the National Dog Bite Prevention Week: Practice News article on feline vaccination http://www.cvm.ncsu.edu/news/2012-05-21- guidelines, March 2012. National-Dog-Bite-Prevention-Week.html

The Bone Marrow Transplant Unit was Dr. Michael Stoskopf was on a detailed mentioned in the New York Times, April 15, Scientific American guest blog about the status 2012. The article resulted in more than 300 of the red wolf population in North Carolina, reader comments and more than 150 March 2012. 11

Dr. Brian Gilger’s ophthalmology research and reported by U.S. and international media. improving vision for animals post-cataract AP video report surgery was the subject of a Technician feature, March 2012. Dr. Richard Ford, who is a member of AAHA canine vaccination task force, is quoted in Dr. Steve Marks is quoted in a Veterinary Veterinary Practice News article concerning Practice News article about pet fevers, canine on vaccines, January 25th. February 9th. Drs. Barbara Sherman and David Dorman Dr. Richard McMullen Jr. is quoted in participated in an Office of Naval Research- Bioptigen press release concerning his cataract hosted “Top Dog Demo 2012” on January 18th surgery of C’sar, the elephant at the NC Zoo, in Southern Pines. February 4th. See the picture: http://www.octnews.org/articles/3417664/bioptig ______en-envisu-sdoct-used-in-rare-elephant-catar/ Personal News Dr. Greg Lewbart was interviewed on the NPR program “This Animal House” January 28th Blikslager AT. Spoke and discussed colic about his pioneering fish surgery. conditions with long-time collaborator Al Merritt

(UFL) at the European Veterinary Conference Cyrano, a cancer-surviving 10-year-old cat, is held in Amsterdam where the drinking age was back home in Upperville, VA following the 16 and pot was legal. His kids were very success of a January 26th knee replacement excited but drank the local water instead of surgery, the first of its kind for a feline, by a indulging. Really Anthony? surgical team led by Dr. Denis Marcellin-Little.

The story was covered in the Associated Press ______

Who Am I

Beth Barlow, Equine Research Technician Hello! I am originally from a rural area of upstate New York, and often people are amused to find that Raleigh is the biggest city I have lived in! I grew up in a very small country town, called Apalachin. The biggest thing the town is known for was the place of the infamous 1957 Mafia Summit that had over 100 of the US and Canadian mafia bosses meeting at a small farmhouse. The local police busted it when it was noticed that there were a lot of very expensive cars arriving, definitely not a normal occurrence! I have lived in North Carolina since 1997, when I came south for college. I graduated from University of North Carolina at Wilmington with a BS in Marine Biology and minor in Chemistry. I have lived in the triangle since, and absolutely love it. I started at the vet school in May of 2001 when I was hired by Drs. Ron Baynes and Jim Riviere in PHP and worked for them until last May, when I switched to DoCS to work for Drs. Jen Davis and Betta Breuhaus as their chemist. I am excited to be part of DoCS. Outside of the vet school I am an active member of the Raleigh Jaycee’s, and have served on their board of directors for several years. I love the community service that I get to do with them, and am often found at the annual Haunted House, working behind the scenes to help build it, and even sometimes making an appearance as “silent” Beth, in the customer queue to help entertain. I quickly found as I was trying to scare people, that my voice is the least scary thing you will ever hear, and by being silent and interacting (often as a street sweeper) with the customer’s in-line, I can scare the pants off them. Who knew! I also enjoy our annual Goodfellow’s project, where we take around 100 underprivileged kids from the Wake County School System, and give them a shopping spree at Belk’s to purchase needed items coats, clothes, and shoes, Christmas dinner, and a visit with Santa (presents and all!). It is always a rewarding experience, and it never fails to put me in the Christmas spirit, I am proud that it is the longest running Jaycee project in the world. We work all year to raise money for the 12 project, with fundraisers such as the Haunted House, the Turkey Shoot at the NC State Fair, and PONY (a girl’s fast pitch softball tournament that brings in over 200 teams to the community for a week). When I am not busy with the Jaycees or at work, I am a complete homebody, and love to play with my dog Liam, quilt, and read. ______

Tonya Lee, Newsletter Editor Next Issue: Fall 2012

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