MYO5A Rabbit Pab

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Leader in Biomolecular Solutions for Life Science MYO5A Rabbit pAb Catalog No.: A9830 Basic Information Background Catalog No. This gene is one of three myosin V heavy-chain genes, belonging to the myosin gene A9830 superfamily. Myosin V is a class of actin-based motor proteins involved in cytoplasmic vesicle transport and anchorage, spindle-pole alignment and mRNA translocation. The Observed MW protein encoded by this gene is abundant in melanocytes and nerve cells. Mutations in 240kDa this gene cause Griscelli syndrome type-1 (GS1), Griscelli syndrome type-3 (GS3) and neuroectodermal melanolysosomal disease, or Elejalde disease. Multiple alternatively Calculated MW spliced transcript variants encoding different isoforms have been reported, but the full- 212kDa/215kDa/218kDa length nature of some variants has not been determined. Category Primary antibody Applications WB,IHC,IF Cross-Reactivity Human, Mouse, Rat Recommended Dilutions Immunogen Information WB 1:500 - 1:2000 Gene ID Swiss Prot 4644 Q9Y4I1 IHC 1:50 - 1:100 Immunogen 1:50 - 1:100 IF Recombinant fusion protein containing a sequence corresponding to amino acids 950-1150 of human MYO5A (NP_000250.3). Synonyms MYO5A;GS1;MYH12;MYO5;MYR12;myosin VA Contact Product Information www.abclonal.com Source Isotype Purification Rabbit IgG Affinity purification Storage Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. Validation Data Western blot analysis of extracts of various cell lines, using MYO5A antibody (A9830) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. Immunohistochemistry of paraffin- Immunohistochemistry of paraffin- Immunohistochemistry of paraffin- embedded rat kidney using MYO5A embedded human liver cancer using embedded human prostate cancer using antibody (A9830) at dilution of 1:100 (40x MYO5A antibody (A9830) at dilution of MYO5A antibody (A9830) at dilution of lens). 1:100 (40x lens). 1:100 (40x lens). Immunohistochemistry of paraffin- embedded human rectum using MYO5A antibody (A9830) at dilution of 1:100 (40x lens). Antibody | Protein | ELISA Kits | Enzyme | NGS | Service For research use only. Not for therapeutic or diagnostic purposes. Please visit http://abclonal.com for a complete listing of recommended products..

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Defining Functional Interactions During Biogenesis of Epithelial Junctions
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Stoica G, Martini-Stoica H. Commentary: Pleiotropic Neuropathological and Biochemical Alterations Neuromedicine associated with Myo5a Mutation in a Rat Model. J Neurol Neuromed (2018) 3(6): 13-16 www.jneurology.com www.jneurology.com Journal of Neurology && NeuromedicineNeuromedicine Commentary Open Access Commentary: Pleiotropic Neuropathological and Biochemical Alterations associated with Myo5a Mutation in a Rat Model George Stoica1*, Heidi Martini-Stoica2 1Texas A&M University, College Station, TX,USA 2Baylor College of Medicine, Houston, TX, USA Article Info Molecular motors have a broad range of functions in the nervous system, including brain wiring, neuronal survival, neuronal Article Notes plasticity, higher brain function, and control of central nervous Received: November 9, 2018 1 Accepted: December 24, 2018 system and peripheral nervous system development . In Landrock et al., a rat model with neurodegeneration, movement disorder, and early *Correspondence: Dr. George Stoica, DVM, MSc., Ph.D., Professor Emeritus, death is associated with loss of function of the molecular motor protein Texas A&M University, College Station, Texas, USA; E-mail: Myosin5a (Myo5a)2. Myo5a, highly expressed in the brain and skin and [email protected]. the predominant neuronal type, is an actin-based motor protein, which © 2018 Stoica G. This article is distributed under the terms of is part of a large group of unconventional myosins. Myosin5a plays a the Creative Commons Attribution 4.0 International License major role in cytoskeletal dynamics in the nervous system, potentially mediating movements of organelles and proteins in neurons3, 4. However, little is known about the precise role of Myo5a in neuronal function Myo5a loss of functionand survival.2.
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