DOCSLIB.ORG

Overview of the Central Nervous System Overview of Cns Functions

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Overview of the Central Nervous System Overview of Cns Functions OVERVIEW OF THE CENTRAL NERVOUS SYSTEM OVERVIEW OF CNS FUNCTIONS • Functions of nervous system (continued): . Integrative functions – include decision-making processes; exclusive function of CNS; includes a wide variety of functions: o Interpretation of sensory information o Planning and monitoring movement o Maintenance of homeostasis o Higher mental functions such as language and learning © 2016 Pearson Education, Inc. BASIC STRUCTURE OF THE BRAIN AND SPINAL CORD • Brain consists of four divisions, each distinct in type of input it receives and where it sends its output: . Cerebrum . Diencephalon . Cerebellum . Brainstem Figure 12.1 Divisions of the brain (lateral view). BASIC STRUCTURE OF THE BRAIN AND SPINAL CORD • Cerebrum – enlarged superior portion of brain; divided into left and right cerebral hemispheres . Each cerebral hemisphere is further divided into five lobes containing groups of neurons that perform specific tasks . Responsible for higher mental function such as learning, memory, personality, cognition (thinking), language, and conscience • Diencephalon – deep underneath cerebral hemispheres; central core of brain . Responsible for processing, integrating, and relaying information to different parts of brain BASIC STRUCTURE OF THE BRAIN AND SPINAL CORD • Cerebellum – posterior and inferior portion of brain . Heavily involved in planning and coordination of movement, especially complex activities such as playing a sport or an instrument • Brainstem – connects brain to spinal cord . Involved in basic involuntary homeostatic functions . Control of certain reflexes . Monitoring movement BASIC STRUCTURE OF THE BRAIN AND SPINAL CORD Figure 12.1 Divisions of the brain (lateral view). © 2016 Pearson Education, Inc. BASIC STRUCTURE OF THE BRAIN AND SPINAL CORD Figure 12.2 White and gray matter in the CNS. © 2016 Pearson Education, Inc. OVERVIEW OF CNS DEVELOPMENT Figure 12.3 Development of the brain. © 2016 Pearson Education, Inc. THE CEREBRUM Figure 12.4b Structure of the cerebrum. © 2016 Pearson Education, Inc. THE CEREBRUM . Frontal lobe . Parietal lobe . Temporal lobe . Occipital lobe . Insula THE CEREBRUM Figure 12.4a Structure of the cerebrum. © 2016 Pearson Education, Inc. THE CEREBRUM . Frontal lobes – most anterior lobes o Neurons in these lobes are responsible for planning and executing movement and complex mental functions such as behavior, conscience, and personality\ . Parietal lobes – just posterior to frontal lobes o Neurons in these lobes are responsible for processing and integrating sensory information and function in attention . Temporal lobes – form lateral surfaces o Neurons in these lobes are involved in hearing, language, memory, and emotions THE CEREBRUM Figure 12.4c Structure of the cerebrum. © 2016 Pearson Education, Inc. THE CEREBRUM-GRAY MATTER • Gray Matter: Cerebral Cortex . Conscious processes such as planning movement, interpreting incoming sensory information . Three areas: primary motor cortex, primary sensory cortices, and association areas THE CEREBRUM-GRAY MATTER 1. Primary motor cortex – plans and executes movement 2. Primary sensory cortices –regions to receive and process sensory input 3. Association areas integrate different types of information: • Unimodal areas • Multimodal areas THE CEREBRUM-GRAY MATTER Figure 12.5 Structure of the cerebral cortex (left hemisphere, lateral view). THE CEREBRUM-GRAY MATTER Motor areas – most are located in frontal lobe; contain upper motor neurons which are interneurons that connect to other neurons (not skeletal muscle) • Primary motor cortex; involved in conscious planning of movement; located in precentral gyrus of frontal lobe THE CEREBRUM-GRAY MATTER Sensory Cortices • Two main somatosensory areas in cerebral cortex; deal with somatic senses . Primary somatosensory area (S1) . Somatosensory association cortex (S2) THE CEREBRUM-GRAY MATTER • Special senses: . Gustatory cortex – taste information processing . Vestibular areas – deal with equilibrium and positional sensations . Olfactory cortex – processes sense of smell THE CEREBRUM-GRAY MATTER Multimodal association areas: • Language – processed in two areas of cortex: . Broca’s area . Wernicke’s area (integrative speech area) . Prefrontal cortex -many functions including modulating behavior, personality, learning, memory, and an individual’s personality state LAB ACTIVITIES Lab Manual Activities: Pg. 106-110 • Activity “Mapping Temperature and Touch” (under arm area) • Activity “Calipers” • Activity “Hands in Warm and Cold Water” • Fill out chart Pg. 111 (Not turned in, but may be on exam) -Post Reponses to Lab Discussion before you leave -Lab Report: 3.3 + 3.4 Q1-17.
Load more

Recommended publications
  • Cerebral Cortex Structure, Function, Dysfunction Reading Ch 10 Waxman Dental Neuroanatomy Lecture Suzanne Stensaas, Ph.D
    Cerebral Cortex Structure, Function, Dysfunction Reading Ch 10 Waxman Dental Neuroanatomy Lecture Suzanne Stensaas, Ph.D. March 15, 2011 Anatomy Review • Lobes and layers • Brodmann’s areas • Vascular Supply • Major Neurological Findings – Frontal, Parietal, Temporal, Occipital, Limbic • Quiz Questions? Types of Cortex • Sensory • Motor • Unimodal association • Multimodal association necessary for language, reason, plan, imagine, create Structure of neocortex (6 layers) The general pattern of primary, association and mulimodal association cortex (Mesulam) Brodmann, Lateral Left Hemisphere MCA left hemisphere from D.Haines ACA and PCA -Haines Issues of Functional Localization • Earliest studies -Signs, symptoms and note location • Electrical discharge (epilepsy) suggested function • Ablation - deficit suggest function • Reappearance of infant functions suggest loss of inhibition (disinhibition), i.e. grasp, suck, Babinski • Variabilities in case reports • Linked networks of afferent and efferent neurons in several regions working to accomplish a task • Functional imaging does not always equate with abnormal function associated with location of lesion • fMRI activation of several cortical regions • Same sign from lesions in different areas – i.e.paraphasias • Notion of the right hemisphere as "emotional" in contrast to the left one as "logical" has no basis in fact. Limbic System (not a true lobe) involves with cingulate gyrus and the • Hippocampus- short term memory • Amygdala- fear, agression, mating • Fornix pathway to hypothalamus •
    [Show full text]
  • Distance Learning Program Anatomy of the Human Brain/Sheep Brain Dissection
    Distance Learning Program Anatomy of the Human Brain/Sheep Brain Dissection This guide is for middle and high school students participating in AIMS Anatomy of the Human Brain and Sheep Brain Dissections. Programs will be presented by an AIMS Anatomy Specialist. In this activity students will become more familiar with the anatomical structures of the human brain by observing, studying, and examining human specimens. The primary focus is on the anatomy, function, and pathology. Those students participating in Sheep Brain Dissections will have the opportunity to dissect and compare anatomical structures. At the end of this document, you will find anatomical diagrams, vocabulary review, and pre/post tests for your students. The following topics will be covered: 1. The neurons and supporting cells of the nervous system 2. Organization of the nervous system (the central and peripheral nervous systems) 4. Protective coverings of the brain 5. Brain Anatomy, including cerebral hemispheres, cerebellum and brain stem 6. Spinal Cord Anatomy 7. Cranial and spinal nerves Objectives: The student will be able to: 1. Define the selected terms associated with the human brain and spinal cord; 2. Identify the protective structures of the brain; 3. Identify the four lobes of the brain; 4. Explain the correlation between brain surface area, structure and brain function. 5. Discuss common neurological disorders and treatments. 6. Describe the effects of drug and alcohol on the brain. 7. Correctly label a diagram of the human brain National Science Education
    [Show full text]
  • Structure and Function of Visual Area MT
    AR245-NE28-07 ARI 16 March 2005 1:3 V I E E W R S First published online as a Review in Advance on March 17, 2005 I E N C N A D V A Structure and Function of Visual Area MT Richard T. Born1 and David C. Bradley2 1Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115-5701; email: [email protected] 2Department of Psychology, University of Chicago, Chicago, Illinois 60637; email: [email protected] Annu. Rev. Neurosci. Key Words 2005. 28:157–89 extrastriate, motion perception, center-surround antagonism, doi: 10.1146/ magnocellular, structure-from-motion, aperture problem by HARVARD COLLEGE on 04/14/05. For personal use only. annurev.neuro.26.041002.131052 Copyright c 2005 by Abstract Annual Reviews. All rights reserved The small visual area known as MT or V5 has played a major role in 0147-006X/05/0721- our understanding of the primate cerebral cortex. This area has been 0157$20.00 historically important in the concept of cortical processing streams and the idea that different visual areas constitute highly specialized Annu. Rev. Neurosci. 0.0:${article.fPage}-${article.lPage}. Downloaded from arjournals.annualreviews.org representations of visual information. MT has also proven to be a fer- tile culture dish—full of direction- and disparity-selective neurons— exploited by many labs to study the neural circuits underlying com- putations of motion and depth and to examine the relationship be- tween neural activity and perception. Here we attempt a synthetic overview of the rich literature on MT with the goal of answering the question, What does MT do? www.annualreviews.org · Structure and Function of Area MT 157 AR245-NE28-07 ARI 16 March 2005 1:3 pathway.
    [Show full text]
  • Basic Brain Anatomy
    Chapter 2 Basic Brain Anatomy Where this icon appears, visit The Brain http://go.jblearning.com/ManascoCWS to view the corresponding video. The average weight of an adult human brain is about 3 pounds. That is about the weight of a single small To understand how a part of the brain is disordered by cantaloupe or six grapefruits. If a human brain was damage or disease, speech-language pathologists must placed on a tray, it would look like a pretty unim- first know a few facts about the anatomy of the brain pressive mass of gray lumpy tissue (Luria, 1973). In in general and how a normal and healthy brain func- fact, for most of history the brain was thought to be tions. Readers can use the anatomy presented here as an utterly useless piece of flesh housed in the skull. a reference, review, and jumping off point to under- The Egyptians believed that the heart was the seat standing the consequences of damage to the structures of human intelligence, and as such, the brain was discussed. This chapter begins with the big picture promptly removed during mummification. In his and works down into the specifics of brain anatomy. essay On Sleep and Sleeplessness, Aristotle argued that the brain is a complex cooling mechanism for our bodies that works primarily to help cool and The Central Nervous condense water vapors rising in our bodies (Aristo- tle, republished 2011). He also established a strong System argument in this same essay for why infants should not drink wine. The basis for this argument was that The nervous system is divided into two major sec- infants already have Central nervous tions: the central nervous system and the peripheral too much moisture system The brain and nervous system.
    [Show full text]
  • Brain Maps – the Sensory Homunculus
    Brain Maps – The Sensory Homunculus Our brains are maps. This mapping results from the way connections in the brain are ordered and arranged. The ordering of neural pathways between different parts of the brain and those going to and from our muscles and sensory organs produces specific patterns on the brain surface. The patterns on the brain surface can be seen at various levels of organization. At the most general level, areas that control motor functions (muscle movement) map to the front-most areas of the cerebral cortex while areas that receive and process sensory information are more towards the back of the brain (Figure 1). Motor Areas Primary somatosensory area Primary visual area Sensory Areas Primary auditory area Figure 1. A diagram of the left side of the human cerebral cortex. The image on the left shows the major division between motor functions in the front part of the brain and sensory functions in the rear part of the brain. The image on the right further subdivides the sensory regions to show regions that receive input from somatosensory, auditory, and visual receptors. We then can divide these general maps of motor and sensory areas into regions with more specific functions. For example, the part of the cerebral cortex that receives visual input from the retina is in the very back of the brain (occipital lobe), auditory information from the ears comes to the side of the brain (temporal lobe), and sensory information from the skin is sent to the top of the brain (parietal lobe). But, we’re not done mapping the brain.
    [Show full text]
  • The Human Brain Hemisphere Controls the Left Side of the Body and the Left What Makes the Human Brain Unique Is Its Size
    About the brain Cerebrum (also known as the The brain is made up of around 100 billion nerve cells - each one cerebral cortex or forebrain) is connected to another 10,000. This means that, in total, we The cerebrum is the largest part of the brain. It is split in to two have around 1,000 trillion connections in our brains. (This would ‘halves’ of roughly equal size called hemispheres. The two be written as 1,000,000,000,000,000). These are ultimately hemispheres, the left and right, are joined together by a bundle responsible for who we are. Our brains control the decisions we of nerve fibres called the corpus callosum. The right make, the way we learn, move, and how we feel. The human brain hemisphere controls the left side of the body and the left What makes the human brain unique is its size. Our brains have a hemisphere controls the right side of the body. The cerebrum is larger cerebral cortex, or cerebrum, relative to the rest of the The human brain is the centre of our nervous further divided in to four lobes: frontal, parietal, occipital, and brain than any other animal. (See the Cerebrum section of this temporal, which have different functions. system. It is the most complex organ in our fact sheet for further information.) This enables us to have abilities The frontal lobe body and is responsible for everything we do - such as complex language, problem-solving and self-control. The frontal lobe is located at the front of the brain.
    [Show full text]
  • Function of Cerebral Cortex
    FUNCTION OF CEREBRAL CORTEX Course: Neuropsychology CC-6 (M.A PSYCHOLOGY SEM II); Unit I By Dr. Priyanka Kumari Assistant Professor Institute of Psychological Research and Service Patna University Contact No.7654991023; E-mail- [email protected] The cerebral cortex—the thin outer covering of the brain-is the part of the brain responsible for our ability to reason, plan, remember, and imagine. Cerebral Cortex accounts for our impressive capacity to process and transform information. The cerebral cortex is only about one-eighth of an inch thick, but it contains billions of neurons, each connected to thousands of others. The predominance of cell bodies gives the cortex a brownish gray colour. Because of its appearance, the cortex is often referred to as gray matter. Beneath the cortex are myelin-sheathed axons connecting the neurons of the cortex with those of other parts of the brain. The large concentrations of myelin make this tissue look whitish and opaque, and hence it is often referred to as white matter. The cortex is divided into two nearly symmetrical halves, the cerebral hemispheres . Thus, many of the structures of the cerebral cortex appear in both the left and right cerebral hemispheres. The two hemispheres appear to be somewhat specialized in the functions they perform. The cerebral hemispheres are folded into many ridges and grooves, which greatly increase their surface area. Each hemisphere is usually described, on the basis of the largest of these grooves or fissures, as being divided into four distinct regions or lobes. The four lobes are: • Frontal, • Parietal, • Occipital, and • Temporal.
    [Show full text]
  • Neocortex: Consciousness Cerebellum
    Grey matter (chips) White matter (the wiring: the brain mainly talks to itself) Neocortex: consciousness Cerebellum: unconscious control of posture & movement brains 1. Golgi-stained section of cerebral cortex 2. One of Ramon y Cajal’s faithful drawings showing nerve cell diversity in the brain cajal Neuropil: perhaps 1 km2 of plasma membrane - a molecular reaction substrate for 1024 voltage- and ligand-gated ion channels. light to Glia: 3 further cell types 1. Astrocytes: trophic interface with blood, maintain blood brain barrier, buffer excitotoxic neurotransmitters, support synapses astros Oligodendrocytes: myelin insulation oligos Production persists into adulthood: radiation myelopathy 3. Microglia: resident macrophages of the CNS. Similarities and differences with Langerhans cells, the professional antigen-presenting cells of the skin. 3% of all cells, normally renewed very slowly by division and immigration. Normal Neurosyphilis microglia Most adult neurons are already produced by birth Peak synaptic density by 3 months EMBRYONIC POSTNATAL week: 0 6 12 18 24 30 36 Month: 0 6 12 18 24 30 36 Year: 4 8 12 16 20 24 Cell birth Migration 2* Neurite outgrowth Synaptogenesis Myelination 1* Synapse elimination Modified from various sources inc: Andersen SL Neurosci & Biobehav Rev 2003 Rakic P Nat Rev Neurosci 2002 Bourgeois Acta Pediatr Suppl 422 1997 timeline 1 Synaptogenesis 100% * Rat RTH D BI E A Density of synapses in T PUBERTY primary visual cortex H at different times post- 0% conception. 100% (logarithmic scale) RTH Cat BI D E A T PUBERTY H The density values equivalent 0% to 100% vary between species 100% but in Man the peak value is Macaque 6 3 RTH 350 x10 synapses per mm BI D E PUBERTY A T The peak rate of synapse H formation is at birth in the 0% macaque: extrapolating to 100% the entire cortex, this Man RTH BI amounts to around 800,000 D E synapses formed per sec.
    [Show full text]
  • Short- and Long-Term Deficits After Unilateral Ablation Andthe Effects of Subsequent Callosal Section’
    0270.6474/84/0404-0918$02.00/0 The Journal of Neuroscience Copyright 0 Society for Neuroscience Vol. 4, No. 4, pp. 918-929 Printed in U.S.A. April 1984 SUPPLEMENTARY MOTOR AREA OF THE MONKEY’S CEREBRAL CORTEX: SHORT- AND LONG-TERM DEFICITS AFTER UNILATERAL ABLATION ANDTHE EFFECTS OF SUBSEQUENT CALLOSAL SECTION’ COBIE BRINKMAN Experimental Neurology Unit, The John Curtin School of Medical Research, Australian National University, Canberra, Australia 2601 Received March 7, 1983; Revised November 11, 1983; Accepted November 15, 1983 Abstract The short-term and long-term behavioral effects of unilateral lesions of the supplementary motor area (SMA) were studied in five monkeys (Mczcaca fascicularis ssp). A monkey with a unilateral lesion of the premotor area (PM) served as a control. In all animals, general behavior was unaffected by the lesions. For a few weeks postoperatively, all monkeys showed a clumsiness of forelimb movements, bilaterally, which involved both the distal and proximal muscles. Two SMA-lesioned monkeys (but not the PM-lesioned one), studied for up to 1 year postoperatively, showed a characteristic deficit of bimanual coordination where the two hands tended to behave in a similar manner instead of sharing the task between them. This deficit was more pronounced after a lesion contralateral to the nonpreferred hand. The deficit was interpreted as indicating that the intact SMA now influenced the motor outflow of both the ipsilateral hemisphere and the contralateral one through the corpus callosum. Callosal section immediately abolished the bimanual deficit, although the clumsiness returned transiently. The results imply that SMA may give rise normally to discharges informing the contralateral hemisphere of intended and/or ongoing movements via the corpus callosum.
    [Show full text]
  • Neurogenesis in Adult Mammals: Some Progress and Problems
    The Journal of Neuroscience, February 1, 2002, 22(3):619–623 Neurogenesis in Adult Mammals: Some Progress and Problems Elizabeth Gould and Charles G. Gross Department of Psychology, Princeton University, Princeton, New Jersey 08544 Approximately 40 years after its first report, the addition of addition, the growing evidence that glia communicate among neurons to the brains of adult mammals has now been generally themselves electrically and have many functional properties that accepted. We now know that several endocrine and experiential interact and overlap with neurons (Rose and Konnerth, 2001; variables modulate adult neurogenesis. However, several meth- Bezzi and Volterra, 2001) suggests that new glia may play a odological problems in its quantitative study remain. One is the significant role. use of low doses of the exogenous marker of cell proliferation, In the 1990s there were several developments that finally es- bromodeoxyuridine (BrdU). A second is the transient lifetime of tablished neurogenesis in the adult rodent. The first was the most of the adult-generated cells. A third is that the survival of introduction of cell type-specific markers for immunohistochem- new neurons may depend on stimuli that are lacking in standard ical identification of the phenotype of newly generated cells laboratory conditions. This review considers these issues as well (Cameron et al., 1993; Okano et al., 1993; Seki and Arai, 1993). as the possible functions of new neurons. These could be combined with 3H-thymidine labeling to deter- From the beginnings of modern neuroscience in the late 19th mine the identity of the new cells. The second was the introduc- century, it was assumed that the mammalian CNS became struc- tion of the thymidine analog BrdU as another in vivo marker of turally stable soon after birth and remained that way throughout proliferating cells (Miller and Nowakowski, 1988; Seki and Arai life.
    [Show full text]
  • How Cells Fold the Cerebral Cortex
    776 • The Journal of Neuroscience, January 24, 2018 • 38(4):776–783 Dual Perspectives Dual Perspectives Companion Paper: How Forces Fold the Cerebral Cortex, by Christopher D. Kroenke and Philip V. Bayly How Cells Fold the Cerebral Cortex Víctor Borrell Instituto de Neurociencias, Consejo Superior de Investigaciones Científicas & Universidad Miguel Herna´ndez, Sant Joan d’Alacant 03550, Spain Foldingofthecerebralcortexisashighlyintriguingaspoorlyunderstood.Atfirstsight,thismayappearassimpletissuecrumplinginside an excessively small cranium, but the process is clearly much more complex and developmentally predetermined. Whereas theoretical modeling supports a critical role for biomechanics, experimental evidence demonstrates the fundamental role of specific progenitor cell types, cellular processes, and genetic programs on cortical folding. Key words: basal Radial Glia; ferret; neurogenesis; OSVZ; Pax6; primate Introduction impact in defining the prospective patterns of cortical folding. In One of the most characteristic features of the human brain is its order for me to review the cellular mechanisms responsible for external folded appearance, due to the 3D arrangement of the cortical folding, I will first begin by defining what is cortical fold- cerebral cortex mantle forming outward folds and inward fis- ing, and what is not. sures. Folding patterns vary significantly between species, while being stereotyped within species. Developmental mechanisms re- Cortical folding sponsible for cortical folding are an intriguing and elusive ques-
    [Show full text]
  • Cortical Parcellation Protocol
    CORTICAL PARCELLATION PROTOCOL APRIL 5, 2010 © 2010 NEUROMORPHOMETRICS, INC. ALL RIGHTS RESERVED. PRINCIPAL AUTHORS: Jason Tourville, Ph.D. Research Assistant Professor Department of Cognitive and Neural Systems Boston University Ruth Carper, Ph.D. Assistant Research Scientist Center for Human Development University of California, San Diego Georges Salamon, M.D. Research Dept., Radiology David Geffen School of Medicine at UCLA WITH CONTRIBUTIONS FROM MANY OTHERS Neuromorphometrics, Inc. 22 Westminster Street Somerville MA, 02144-1630 Phone/Fax (617) 776-7844 neuromorphometrics.com OVERVIEW The cerebral cortex is divided into 49 macro-anatomically defined regions in each hemisphere that are of broad interest to the neuroimaging community. Region of interest (ROI) boundary definitions were derived from a number of cortical labeling methods currently in use. Protocols from the Laboratory of Neuroimaging at UCLA (LONI; Shattuck et al., 2008), the University of Iowa Mental Health Clinical Research Center (IOWA; Crespo-Facorro et al., 2000; Kim et al., 2000), the Center for Morphometric Analysis at Massachusetts General Hospital (MGH-CMA; Caviness et al., 1996), a collaboration between the Freesurfer group at MGH and Boston University School of Medicine (MGH-Desikan; Desikan et al., 2006), and UC San Diego (Carper & Courchesne, 2000; Carper & Courchesne, 2005; Carper et al., 2002) are specifically referenced in the protocol below. Methods developed at Boston University (Tourville & Guenther, 2003), Brigham and Women’s Hospital (McCarley & Shenton, 2008), Stanford (Allan Reiss lab), the University of Maryland (Buchanan et al., 2004), and the University of Toyoma (Zhou et al., 2007) were also consulted. The development of the protocol was also guided by the Ono, Kubik, and Abernathy (1990), Duvernoy (1999), and Mai, Paxinos, and Voss (Mai et al., 2008) neuroanatomical atlases.
    [Show full text]