INSIGHT 2016 ANNUAL REPORT KECK SCHOOL OF MEDICINE OF USC DEPARTMENT OF OPHTHALMOLOGY Gayle and Edward Roski made a transformative $25 million gift in 2016 to endow and name the USC Roski Eye Institute, further advancing the institute’s position as one of the nation’s leading centers for advanced vision care, research and education.
“ Our gratitude to the Roski family is profound. With this gift, we will continue to make progress toward our most ambitious goal — eliminating blindness.”
Rohit Varma, MD, MPH, Director, USC Roski Eye Institute INSIGHT is the driving force behind everything we do at the USC Roski Eye Institute.
Insight begins with envisioning a future without blindness.
Insight grows by learning from each courageous patient.
Insight deepens through continual discovery and invention.
Insight triumphs when we come together to preserve vision.
Insight renews as each new generation seeks and serves.
INSIGHT 2016 provides a glimpse into the accomplishments of our 41st year.
We are deeply indebted to the patients, families, philanthropists, physicians, scientists, researchers, caregivers, residents, technicians, entrepreneurs, administrators, managers, and countless others who join us in our mission to eliminate blindness. All of you make the USC Roski Eye Institute everything it is, and everything it will be.
With gratitude,
Rohit Varma, MD, MPH Dean, Keck School of Medicine of USC May S. and John Hooval Dean’s Chair in Medicine Grace and Emery Beardsley Chair in Ophthalmology Director, USC Roski Eye Institute
(Opposite page, from left) Rohit Varma, Edward P. Roski Jr., Gayle Garner Roski, Robert Day, Niki Nikias, USC President C.L. Max Nikias, and Mark Humayun give the USC “Fight On” sign.
1 VISION IS OUR MISSION PRESERVE. PROTECT. RESTORE.
Fulfillment of our mission is best expressed in the remarkable triumphs of our patients. Please read their stories in the pages ahead.
PRESERVE PROTECT RESTORE The USC Roski Eye Institute diagnoses, The USC Roski Eye Institute leads major The USC Roski Eye Institute integrates treats and manages the most complex research in the epidemiology of eye and applies emerging technologies to eye conditions, from in utero to disease to help prevent blindness. develop new methods to restore sight advanced age. to the blind.
2 usceye.org VISION IS OUR MISSION PRESERVE. PROTECT. RESTORE.
INSIGHT 2016 ANNUAL REPORT
Patient Care 6 Research 18 Preserving Sight 32 Clinical Education 37 Publications 50
3 MAJOR ACCOLADES AND ACHIEVEMENTS
World’s 100 Most Influential People in Ophthalmology Awarded by The Ophthalmologist From left, Carmen Puliafito, MD, MBA, Mark S. Humayun, MD, PhD, and Farhad Hafezi, MD, PhD.
Nation’s Best Hospitals 2016 AAO LIFE for Ophthalmology ACHIEVEMENT HONOR 2016-17 AWARD Nationally Top Ranked Ophthalmology Program
Rohit Varma, MD, MPH, director, USC Roski Eye Institute, was presented with the award at the 2016 American Academy of Ophthalmology conference in Chicago.
BEST DOCTORS IN AMERICA® #2 2015-16 IN RESEARCH FUNDING 2016 Four USC Roski Eye Institute faculty by the National Eye Institute named among the best
4 usceye.org National Medal of SUPER DOCTORS OF Technology SOUTHERN CALIFORNIA 2016 13 USC Roski Eye Institute faculty and Innovation named among the best The nation’s highest honor for technology achievement
U.S. Ophthalmo#9 logy President Barack Obama and National Medal recipient Mark S. Humayun, MD, PhD, co-director of the USC Roski Eye Institute Residency Program 2016 and director of the USC Institute for Biomedical Therapeutics. by Doximity
NEW TEXTBOOKS FROM USC ROSKI EYE INSTITUTE FACULTY 2016
(Left to right) Advanced Glaucoma Surgery Editors: Ahmad A. Aref and Rohit Varma; Clinical Neuro-Ophthalmology: The Essentials Authors: Neil R. Miller, Prem S. Subramanian and Vivek Patel; Corneal Collagen Cross-Linking (translated into Chinese) Authors: Farhad Hafezi and J. Bradley Randleman; Corneal Cross-Linking Editors: Farhad Hafezi and J. Bradley Randleman; Intraocular Inflammation Editors: Manfred Zierhut, Carlos Pavesio, Shigeaki Ohno, Fernando Orefice, Narsing A. Rao; Intraocular Lens Surgery Editor: J. Bradley Randleman; Optical Coherence Tomography and OCT Angiography Authors: Darrin A. Landry and Amir H. Kashani.
5 INSIGHT Patient Care
The USC Roski Eye Institute is dedicated to managing or curing eye conditions by applying the most advanced knowledge, skills, technologies and methods.
6 usceye.org PATIENT CARE
HIGHLY SPECIALIZED CARE FOR ADULTS AND CHILDREN The USC Roski Eye Institute treats the full spectrum of eye conditions — from the most common to the most complex.
CATARACTS OCULAR ONCOLOGY Anterior Segment and Iris Tumors, CORNEA AND , EXTERNAL DISEASES Basal Cell Carcinoma, Conjunctival TOTAL Tumors, Conjunctival Melanoma, Blepharitis, Bullous Keratopathy, PATIENT VISITS Lid Tumors, Lymphoma, Melanoma, Chalazia/Styes, Conjunctivitis, Corneal Metastatic Lesions, Ocular Surface Dystrophies, Fuchs Endothelial Squamous Neoplasia, Optic Nerve Dystrophy, Corneal Infection, Corneal Lesions, Orbital Lesions, Sebaceous Scarring, Dry Eye Syndrome, Herpes Cell Carcinoma of the Lid, Squamous Keratitis, Keratoconus, Pterygium, PEER REVIEWED Cell Carcinoma, Vascular Lesions, Ocular Rosacea PUBLICATIONS Uveal Lesions GLAUCOMA OCULOFACIAL Angle Closure Glaucoma, Open-Angle PLASTIC SURGERY Glaucoma, Congenital and Childhood OPHTHALMIC MOLECULAR AND WORLD WIDE Glaucoma, Pseudoexfoliation IMMUNOPATHOLOGY Glaucoma, Glaucoma Secondary to PATIENT CARE PEDIATRIC OPHTHALMOLOGY Eye Trauma, Neovascular Glaucoma, Normal Tension Glaucoma, SPECIALTY CONTACT LENSES Pigment Dispersion Glaucoma, AND PROSE Uveitic Glaucoma UVEITIS AND OCULAR INFLAMMATION ACTIVE RESEARCH GRANTS LASER VISION CORRECTION Chorioretinitis, Herpetic Uveitis, Anisometropia, Astigmatism, HLA-B27 Iridocyclitis, Ocular . Hyperopia, Keratoconus, Tuberculosis, Toxoplasmosis, Vogt- MILLION Myopia, Presbyopia Koyanagi-Harada Disease FEDERAL GRANT EXPENDITURES
NEURO-OPHTHLAMOLOGY AND VITREORETINAL SURGERY ADULT STRABISMUS AND RETINAL DISEASE Blepharospasm, Double Vision, Age-related Macular Degeneration Hemifacial Spasm, Idiopathic (Wet and Dry), Central Serous Intracranial Hypertension, Optic Chorioretinopathy, Diabetic Macular Neuropathy, Papilledema, Stroke, Edema, Diabetic Retinopathy, Macular FACULTY MEMBERS Temporal Arteritis, Thyroid Eye Hole, Macular Pucker, Posterior Disease, Visual Field Defects Vitreous Detachment, Retinal Detachment, Retinal Tears, Retinal USCEYE.ORG Vein Occlusion, Retinitis Pigmentosa
7 Jessica Marquez
Congenital Glaucoma Corneal Edema/ Cloudiness
OCULAR HISTORY Previous treatment for glaucoma. Failed corneal transplant left significant scar tissue in right eye. Growing up with severe vision problems, Jessica never thought of herself as different.
TREATMENT Legally blind for most of her life, Jessica Marquez began the battle to Full thickness corneal transplant save her vision as a young child. An extreme sensitivity to light and poor and glaucoma valve revision. eyesight led to a diagnosis of glaucoma and cloudy corneas in both eyes. Over the years, treatment for Jessica’s condition included surgeries and OUTCOME setbacks that took a further toll on her vision. Cornea is clear in right eye. Vision improved dramatically. Jessica eventually came to the USC Roski Eye Institute in hopes that her vision could be saved. A team of corneal, retinal and glaucoma specialists examined Jessica and developed a comprehensive plan to maximize the efficiency of treatment while reducing further trauma to her eyes. Her eye pressure is now under control and her eyesight has been preserved.
Despite having very little vision and enduring more than 40 eye surgeries, Jessica has achieved remarkable success. With her parent’s loving support, she kept her eyes on the future. She excelled in school, eventually earning a master’s degree and becoming a professor who teaches public speaking at Orange Coast College. “Education is power,” Jessica says. “Don’t let anything stand in your way.”
Top image shows a normal optic nerve head. Bottom image shows damage to the optic nerve head from glaucomatous cupping.
Alena Reznik, MD, Amir Kashani, MD, PhD, and Jonathan Song, MD, are working together to preserve Jessica’s vision.
8 usceye.org I found great hope in the atmosphere here because “ I always feel like I am part of the family. Jessica Marquez ”
9 REVOLUTIONIZING GLAUCOMA SURGERY
Approved this year by the FDA, the new XEN® Glaucoma Treatment Ron Bache, BS System redefines surgical intervention for glaucoma through the innovative application of a permanent, flexible implant that drains eye fluid to reduce intraocular pressure.
Developed by USC alumnus and entrepreneur Ron Bache, ’91 with scientific support from Rohit Varma, MD, MPH, the XEN gel stent was proven in large clinical trials to be effective with minimal side effects. Surgical implantation Rohit Varma, MD, MPH with a specially developed injector applicator simplifies and standardizes the procedure for optimal results that are easily replicated.
This revolutionary intervention has great potential to preserve vision for the nearly 80 billion people worldwide who are estimated to have or who will develop glaucoma by 2020.
The XEN® Glaucoma Treatment System reduces intraocular eye pressure with a tiny flexible stent that is implanted using an injector applicator.
10 usceye.org PATIENT CARE
J. Bradley Randleman, MD, performs the CXL procedure that uses a combination of ultraviolet-A light irradiation and application of riboflavin (vitamin B2) eye drops to stabilize the cornea.
ADVANCING CORNEAL CROSS-LINKING
Approved this year by the FDA, corneal cross-linking (CXL) is an innovative procedure that provides effective treatment for keratoconus, an eye disease that J. Bradley Randleman, MD destroys vision by distorting the cornea into a cone shape.
In the clinic, J. Bradley Randleman, MD, was a principal investigator for two FDA- sponsored U.S. clinical trials demonstrating that CXL can stabilize the cornea and halt the progression of the disease. In the field, Farhad Hafezi, MD, PhD, is leading a clinical study on the incidence of keratoconus in Saudi Arabia, where the disease is believed to be more prevalent.
Together, these USC Roski USC Eye Institute researchers are working to overcome a disease that is the leading cause of severe visual impairment among children Farhad Hafezi, MD, PhD and adults worldwide.
11 Adam Lyons
Keratoconus
OCULAR HISTORY Good vision in left eye with contact lens after corneal transplant 10 years ago. Poor vision in right eye from keratoconus. Contact lens intolerant.
TREATMENT Adam enjoys travel and outdoor activities with his family. Underwent corneal cross- linking (CXL), a new treatment for keratoconus that stops the With his cornea changing shape from keratoconus, Adam’s vision in his progression of the disease and right eye worsened and he was no longer able to wear a contact lens. can partially reverse some of the Jonathan Song, MD, examined Adam and recommended an innovative corneal changes. procedure called corneal cross-linking (CXL). The USC Roski Eye Institute is the first site in the Los Angeles region to have the approved device and OUTCOME offer CXL treatment. In the healing phase and doing well. CXL, recently approved by the FDA for use in the United States, is the first and only treatment that can actually halt the progression of keratoconus, and in some cases can partially reverse it. J. Bradley Randleman, MD, performed the procedure on Adam, which consists of dispersing riboflavin eye drops for 30 minutes followed by another 30 minutes of exposure to ultraviolet light.
The procedure was effective in helping to reshape the cornea. Adam’s eye is healing well and his vision is improving.
Image of the cornea during CXL treatment. The green glow of the cornea results from the yellow riboflavin drops fluorescing under the blue ultraviolet light.
J. Bradley Randleman, MD, left, performed the CXL procedure on Adam’s right eye, and Jonathan Song, MD, previously performed a corneal transplant on his left eye. “
12 usceye.org I’ve been in good hands throughout my exams, the corneal “ transplant and the new corneal cross-linking treament. Adam Lyons ”
13 EVALUATING FITNESS- TRACKING EYEWEAR
Imagine if eyeglasses could provide an edge in improving overall health. An innovative product that seamlessly integrates fitness-tracking technology into an Gloria Chiu, OD, FAAO, FSLS optical frame is being distributed through the USC Roski Eye Institute as part of a pilot study. “ The fashion-forward eyeglasses measure a wearer’s steps, calories burned, The result is distance traveled and activity, and connect wirelessly to track progress through an accompanying smartphone application.
better vision Gloria Chiu, OD, FAAO, FSLS, who leads the study’s eye care team, believes the and better eyeglasses will provide more reliable and consistent tracking than wristbands ” that are subject to vigorous hand movement or not being worn. The result is fitness. better vision and better fitness.
The eyeglasses, developed by VSP Global in partnership with the USC Center for Body Computing, are shown here with a clear temple that reveals the hidden accelerometer, magnetometer and gyroscope that provide biometric measurement.
14 usceye.org PATIENT CARE
The new Retinal Degeneration Center surrounds patients with advanced clinical care and breakthrough research.
LAUNCHING THE RETINAL DEGENERATION CENTER
Children and adults who inherit retinitis pigmentosa (RP) and similar conditions now have greater resources to help preserve their sight. The new Retinal Degeneration Center at the USC Roski Eye Institute combines clinical care and research to deliver a Hossein Ameri, MD, PhD full spectrum of specialized care for these rare and potentially blinding diseases.
Through comprehensive ophthalmic electrophysiology testing, specialists diagnose RP, cone dystrophy, Usher syndrome, Stargardt disease, Best disease, choroideremia and achromatopsia, and then develop effective personalized treatment plans.
The center also conducts clinical and basic science research into gene therapy, stem cell–based therapies and retinal prosthesis, including the Argus II retinal prosthesis for advanced stages of RP. The result is better care today and more possibilities for tomorrow. Mark Borchert, MD
15 PROVIDING OPHTHALMIC PATHOLOGY EXPERTISE
The USC Roski Eye Institute Ophthalmic Molecular and Immuno-Pathology laboratory, one of the few in the country, continues to expand. It excels in the Narsing A. Rao, MD study of delicate, often minute tissue samples, and provides an important resource for clinicians, educators and researchers. “ An eye pathology fellowship was inaugurated in 2016 with the appointment of fellow The pathology Lei-Chi Wang, MD, an investigator from Taiwan, and a new eye pathology rotation laboratory delivers more robust diagnostic training. is growing The laboratory also added a medical examiner to support forensic investigations. In child abuse cases, for example, analysis of retinal bleeding can determine whether to meet abuse is recent or recurring.
increasing In its scope and size, the pathology laboratory is growing to meet increasing needs. needs.”
Laboratory Director Narsing A. Rao, MD, promotes its local and global reach in clinical care, Images of an injured eye examined for a forensic education and research. investigation.
16 usceye.org PATIENT CARE
SAVING SIGHT VIRTUALLY ANYWHERE
The USC Roski Eye Institute is using virtual reality, artificial intelligence and wearable sensors to provide on-demand, 24/7, global access to expert eye care and information. This is made possible by becoming the first clinical partner in the Virtual Care Clinic program being developed by the USC Center for Body Computing.
Using a smartphone or tablet, patients can interact with “virtual doctor” avatars of USC Roski Eye Institute specialists, watch videos explaining diagnosis and use wearable sensors to track response to medication or treatments. On-demand eye care will not only increase convenience for patients, but will also provide access to the highest levels of ophthalmology expertise and care where it is Top: Rohit Varma, MD, MPH, in the currently unavailable. Virtual Care Clinic photo scanning booth. Bottom: “Virtual doctor” avatars of Varma and Leslie Saxon, MD, executive director of the USC Center for Body Computing
Advanced technologies will connect USC Roski Eye Institute specialists with patients at any location.
17 INSIGHT Research
The USC Roski Eye Institute improves lives through scientific discovery and technical innovation that results in new treatments that overcome visual impairment and blindness.
18 usceye.org RESEARCH
President Barack Obama presented the National Medal of Technology and Innovation to Mark Humayun, MD, PhD, at the White House on May 19, 2016.
HONORING A PASSION FOR INNOVATION
As a child, Mark S. Humayun decided to dedicate his life to studying ophthalmology after helplessly watching his grandmother go blind. Decades later, he received the nation’s highest technology award for leadership in bridging medicine and engineering to help restore eyesight.
Humayun is best known for his role in developing Argus II, the only FDA-approved The knowledge produced retinal prosthesis system that enables people with certain blinding diseases to “by these Americans today regain some useful vision. Beyond pursuing further refinement of the artificial will carry our country’s retina, Humayun is leading a multi-university consortium to develop a stem cell legacy of innovation implant for age-related macular degeneration. forward and continue to help countless others around the world. President Barack Obama on” the recipients of the National Medal of Technology and Innovation
19 Active Research Funding as of December 2016
PROJECT SOURCE PRINCIPAL INVESTIGATOR Imaging Cerebral and Retinal Microvasculature in Cerebral Small Vessel Disease NIH Amir Kashani, MD, PhD Functional Imaging in Hypoxic-Ischemic Retinal Disease NIH Amir Kashani, MD, PhD Study of Subretinal Implantation of Human Embryonic Stem Cell-Derived RPE Cells in CIRM Amir Kashani, MD, PhD Advanced Dry AMD Carl Zeiss Meditec, OCT Angiography Research Consortium (OARC) Amir Kashani, MD, PhD Inc. Hyperspectral OCT System for Metabolic Retinal Imaging USC Amir Kashani, MD, PhD Optimizing Stimulation Strategies for Cortical Visual Prostheses U.S. Army Andrew Weitz, PhD Restoring Vision By Sheet Transplants of Retinal Progenitors and Retinal Pigment Epithelium CIRM Biju Thomas, PhD (RPE) Derived from Human Embryonic Stem Cells (hESCs) BrightFocus Studies on Functionality of iPS-RPE Transplanted in Immunodeficient RCS Rats Biju Thomas, PhD Foundation Parylene for Subconjunctival Patch Grafts and for Continuous Intraocular Pressure Sensors Whittier Foundation Damien Rodger, MD, PhD An Experimental Approach to Maculopathy NIH David Hinton, MD Research to Prevent Blindness Career Development Award RPB J. Martin Heur, MD, PhD Mentoring for the Advancement of Physician-Scientists Award AGS Grace Richter, MD, MPH Novel Ultra-Flexible Hybrid Circuits for Intracular Retinal Prostheses NIH James Weiland, PhD Experimental and Clinical Investigations of Retinal Stimulation NIH James Weiland, PhD INSPIRE: Bioelectronic Systems for Investigating Neural Plasticity NSF James Weiland, PhD EFRI-BioFlex: Hybrid Polymer-Paper Based Multi-Sensor Implants for Continuous Remote NSF James Weiland, PhD Monitoring Human Connectomes in Low Vision, Blindness and Sight Restoration NIH James Weiland, PhD Retinal Prosthesis Neural Imaging: Measuring the Impact of Crossmodal Plasticity on Visual Beckman Foundation James Weiland, PhD Restoration (Arnold O. Beckman Postdoctoral Fellow: Noelle Stiles) Enhanced Biocompatible Materials for the Repair of Ocular Injuries U.S. Army John Whalen, PhD Retinal Nanophotoswitch NSF Mark Humayun, MD, PhD Phase 1 Safety Assessment of CPCB-RPE1, hESC-derived RPE Cell Coated Parylene CIRM Mark Humayun, MD, PhD Membrane Implants, in Patients with Advanced Dry Age Related Macular Degeneration Thermoresponsive Reversible Adhesive for Temporary Intervention of Ocular Trauma - II U.S. Army Mark Humayun, MD, PhD Dual-frequency Intravascular Arrays for Functional Imaging of Atherosclerosis NIH Qifa Zhou, PhD Characterizing Atherosclerosis by Integrated Multimodality Imaging System NIH Qifa Zhou, PhD Elastographic Imaging of the Retina/Choroid in Age-Related Macular Degeneration NIH Qifa Zhou, PhD High Resolution Elastography of Retina Under Prosthetic Electrical Stimulation NIH Qifa Zhou, PhD Phase Resolved ARF Optical Coherence Elastography for Intravascular Imaging NIH Qifa Zhou, PhD Mexican American Glaucoma Genetic Study NIH Rohit Varma, MD, MPH African American Eye Disease Study NIH Rohit Varma, MD, MPH Primary Open Angle African-American Glaucoma Genetics NIH Rohit Varma, MD, MPH Research to Prevent Blindness (RPB) Unrestricted RPB Rohit Varma, MD, MPH Sarah Hamm-Alvarez, Novel Stem Cell Therapy for Dry Eye Syndrome with Enhanced Viability and Long-Term Efficacy RPB PhD Tear fluid and serum levels of Cathepsin S and its endogenous inhibitor Cystatin C as Sjögren's Syndrome Sarah Hamm-Alvarez, biomarkers for Sjögren's Syndrome Foundation PhD Sarah Hamm-Alvarez, Microtubule-Based Transport in Lacrimal Gland Function NIH PhD The Pediatric Eye Disease Consortium: a Pooled Analysis of Individual-Participant Data NIH Xuejuan Jiang, PhD from Population-based Studies Helicobacter Pylori Infection and Primary Open-angle Glaucoma among Mexican USC Xuejuan Jiang, PhD Americans: an Example of Microbiota-Gut-Brain Axis? Long-term Outcomes and Genetic Basis of Early-onset Refractive Errors in Preschool USC Xuejuan Jiang, PhD Children
AGS (American Glaucoma Society) • CIRM (California Institute for Regenerative Medicine) • GSK (GlaxoSmithKline) NIH (National Institutes of Health) • NSF (National Science Foundation) • RPB (Research to Prevent Blindness)
20 usceye.org RESEARCH
EXPLORING THE BRAIN’S
ROLE IN BLINDNESS IN MEMORIAM BOSCO TJAN, PhD By understanding how the brain responds to low vision and blindness, USC Roski Eye Institute researchers strive to understand in unprecedented detail, the structural and functional connections of the visual brain.
A $4 million, four-year study funded by the National Institutes of Health will build upon the brain mapping techniques developed for the Human Connectome Project. Our team of researchers will recruit more than 100 patients with macular degeneration, retinitis pigmentosa and various optic nerve disorders, in their efforts to study how individual brains adapt to visual disorders over time.
Deeper understanding of the visual brain holds great promise for future innovations. If differences in the central visual pathways behind the retina and optic nerve caused by eye disorders can be observed earlier, treatments to preserve vision can be Bosco Tjan, PhD, professor developed sooner. of psychology at the USC Dornsife College of Letters, Collaborating on study are Hossein Ameri, MD, PhD, Amir Kashani, MD, PhD, Arts and Sciences and Andrew Moshfeghi, MD, MBA, Vivek Patel, MD, and James Weiland, PhD. co-director of USC Dana and David Dornsife’s Cognitive Neuroimaging Center, died tragically Dec. 2, 2016.
Tjan was a world-renowned expert in the field of vision loss research and was principal investigator in the study to discover how the brain reacts to blindness.
During a tribute service on USC University Park Campus, he was remembered as an Figure 1: Cortical thickness (medial view of the cortices). insightful and generous colleague, an outstanding teacher, a prolific researcher and an exceptional collaborator.
He is survived by his wife and son.
Figure 2: Cortical response (fMRI) to light (medial view of the cortices).
21 The doctors worked with skill and earned my confidence, “ and now I can see clearly again. Mark Sweeney ”
22 usceye.org Mark Sweeney
Fuchs Dystrophy and Cataracts
OCULAR HISTORY Vision loss from Fuchs dystrophy and cataracts caused difficulty with driving and enjoying activities.
TREATMENT Now that his vision has been restored, Mark has returned to outdoor activities and Combined Descemet’s Membrane and attending concerts with renewed excitement. Endothelial Keratoplasty (DMEK) and cataract surgery. A continuing blur in his right eye led Mark Sweeney to contact the USC Roski Eye Institute. Karen Morgan, MD, examined Mark and OUTCOME determined that he had Fuchs dystrophy, a swelling and clouding of Complete restoration of vision one the cornea. She began conservative treatment with eye drops, but month after each surgery. then determined that a more invasive approach was needed. J. Martin Heur, MD, PhD, recommended combined DMEK and cataract surgery. The procedure was successful, and within one month the vision in Mark’s right eye not only was clear, but also corrected so he would not need glasses. His vision began blurring in his left eye, so Mark was excited and confident to have Heur repeat the procedure so he would have sharp vision in both eyes. Mark was delighted to get back to playing golf and seeing all the details at concerts at the Hollywood Bowl —without wearing glasses. “I can finally see clearly,” Mark says. “It’s truly amazing.” Image of the eye shows corneal swelling and cloudiness from Fuchs dystrophy.
Karen Morgan, MD, and J. Martin Heur, MD, PhD, worked together to restore and improve vision in both eyes for Mark.
23 Sarah Hamm-Alvarez (center) is surrounded by her research team (from left to right) Zhen Meng, Srikanth Janga, Maria Edman and Christina Fu.
“Our discovery DETECTING DISEASE will help WITH TEARDROPS
diagnose and By discovering a biomarker in teardrops, Sarah Hamm-Alvarez, PhD, and her treat Sjögren’s research team may advance treatment of Sjögren’s syndrome. The disease can have devastating effects as immune cells attack mucous membrane and fluid- syndrome.” secreting glands. It starts with dryness in the eyes and mouth, but eventually progresses to damage major organs. No single test exists to confirm Sjögren’s syndrome, so diagnosis can take years.
“Our discovery will help diagnose and treat Sjögren’s syndrome more effectively, particularly the dry-eye side effect of the disease,” said Hamm- Alvarez. The promise of a simple tear-based test has the potential to improve life for the four million people in the U.S. who have Sjögren’s syndrome. Nine out of 10 patients are women who would be protected from the dire consequences of the disease.
Sarah Hamm-Alvarez, PhD
24 usceye.org RESEARCH
A cortical visual prosthesis consists of a miniature video camera built into the nosepiece of eyeglasses, signal-processing electronics carried in a pocket and arrays of microelectrodes implanted in the primary visual cortex. (Courtesy of Nature Publishing Group)
SEEING WITH THE BRAIN “A novel — WITHOUT EYES imaging
Electrical stimulation of the visual neurons could enable the blind to see technique is again—without using their eyes. Cortical visual implants use the brain to advancing “see” by capturing images on a video camera built into specialty eyeglasses and relaying them to electrodes implanted in the visual cortex. A major cortical challenge is to precisely stimulate target nerve cells to provide accurate vision. Andrew Weitz, PhD, and his research team developed a novel imaging implants.” technique to map the patterns of cells activated by electrical stimulation. They then identified stimulus waveform shapes that enable precise stimulation of nerve cells in the retina for retinal implants. Now the team is developing waveforms for the visual cortex. By enabling precise control of patterns of neurons stimulated by cortical visual implants, they hope to restore accurate vision to people who have lost their eyes.
Andrew Weitz, PhD
25 In this figure, 15-20 MHz convex phased array will not only provide a larger viewing angle and field of view than traditional linear arrays, but it will also be better at providing enough acoustic output and uniform acoustic field to generate dynamic vibration of retinal tissue over the traditional array. The phase array can be changed focus beam by electronic scanning. Meanwhile, high resolution OCT can detect cell structure changes of the retina with ultrasonic stimulation. REVERSING BLINDNESS WITH ULTRASOUND
What if blindness could be reversed without surgery. Current methods for restoring sight from lost retinal receptor cells involve implanting devices to stimulate surviving retinal neurons.
Ultrasound waves are known to stimulate sight-giving retinal neurons. Using ultrasound to restore sight would require a specialized device to deliver ultrasound Mark Humayun, MD, PhD waves and the ability to map stimulation patterns. USC Roski Eye Institute researchers Mark Humayun, MD, PhD, and Qifa Zhou, PhD, are taking on these challenges.
Their goal is to develop ultrasonic single-element transducer/phased arrays for retinal stimulation, and design an optimal stimulation paradigm to produce controllable, consistent retinal responses with high spatiotemporal resolution — and provide in vivo validation.
Ultrasound therapies hold the promise of ending blindness on a scale far beyond Qifa Zhou, PhD current methods.
26 usceye.org RESEARCH Accelerating Progress through Collaboration The USC Roski Eye Institute works closely with many individual researchers and organizations to advance vision science and clinical ophthalmology. We gratefully acknowledge colleagues for their efforts in 2016.
INDIVIDUALS USC (Schaeffer Center for Health Policy Bioengineering Initiative Seth Seabury, PhD and Economics) COLLABORATOR ORGANIZATION Yonggang Shi, PhD USC (Neurology) Theodore Berger, PhD USC (Biomedical Engineering) Olaf Sporns, PhD Indiana University, IN Robert Chow, MD, PhD USC (Zilkha Neurogenetic Institute) Michael Weiner, MD Northern California Institute for Scott E. Fraser, PhD USC (Biomedical Engineering) Research & Education, CA Malancha Gupta, PhD USC (Materials Science) Wenle Zhao, PhD Medical University of South Carolina, SC Hossein Hashemi, PhD USC (Electrical Engineering) Imaging Initiative Laurent Itti, PhD USC (Computer Science) COLLABORATOR ORGANIZATION Gianluca Lazzi, PhD University of Utah, UT Antonio Capone, MD Oakland University, MI Mark Liker, MD USC (Neurosurgery) Zhongping Chen, PhD UCI Samueli School of Engineering, CA Gerard Medioni, PhD USC (Computer Science) Thomas Karnowski, PhD Oak Ridge National Labs, TN Ellis Meng, PhD USC (Biomedical Engineering) Michael Trese, MD Oakland University, MI Alapakkam Sampath, PhD UCLA Brain Research Institute George Williams, MD Oakland University, MI Kirk Shung, PhD USC (Biomedical Engineering) National Aeronautics and Space Dong Song, PhD USC (Biomedical Engineering) Mark Wong, PhD Administration, MD Armand Tanguay, PhD USC (Electrical Engineering) Ocular Epidemiology Cross-Linking and Refractive Surgical Outcomes COLLABORATOR ORGANIZATION COLLABORATOR ORGANIZATION Stanley Azen, PhD USC (Preventive Medicine) William J. Dupps, MD, PhD USC (Biomedical Engineering) Xiaoyi Gao, PhD University of Illinois at Chicago, IL Farhad Hafezi, MD, PhD The USC Roski Eye Institute and ELZA James Gauderman, PhD USC (Preventive Medicine) Institute, Switzerland Joanne Katz, ScD Johns Hopkins University, MD University of Sao Paulo, Brazil and Ronald Klein, MD, MPH University of Wisconsin-Madison, WI Marcony Santhiago, MD, PhD Federal University of Rio de Janeiro Roberta McKean-Cowdin, PhD USC (Preventive Medicine) University of Maryland Fischell School Giuliano Scarcelli, PhD of Engineering, MD Joan M. O’Brien, MD University of Pennsylvania, PA Jeremy Rotter, PhD Los Angeles Biomedical Institute, CA Human Connectome Project Kristina Tarczy-Hornoch, MD Seattle Children's Hospital, WA COLLABORATOR ORGANIZATION Tien Wong, MD, PhD National University of Singapore James T. Becker, PhD University of Pittsburgh, PA Adam L. Boxer, MD, PhD USCF Memory and Aging Center Regenerative Medicine for Blinding Eye Diseases Kyle Chard, PhD University of Chicago, IL COLLABORATOR ORGANIZATION Kristi Clark, PhD USC (Neurology) Larry A. Couture, PhD City of Hope, CA Eric Deutsch, PhD Institute for Systems Biology, WA Dennis Clegg, PhD UCSB Center for Stem Cell Biology and Ivo Dinov, PhD University of Michigan, MI Engineering James Duncan, PhD Yale University, CT Lincoln V. Johnson, PhD UCSB Center for the Study of Macular Jerome Engel, MD UCLA David Geffen School of Medicine Degeneration Ian Foster, PhD University of Chicago, IL Population Health Giovanni Frisoni, MD IRCCS Fatebenefratelli, Italy COLLABORATOR ORGANIZATION Gustavo Glusman, PhD Institute for Systems Biology, WA Dana Goldman, PhD USC (School of Pharmacy), USC (Sol Dana Goldman, PhD USC (Schaeffer Center for Health Policy Price School of Public Policy) and Economics) Anupam Jena, MD, PhD Harvard University, MA Gerig Guido, PhD University of Utah, UT Geoffrey Manley, MD, PhD UCSF School of Medicine Susan Hayflick, MD Oregon Health & Science University, OR USC (Department of Emergency Cincinnati Children’s Mike Menchine, MD Medicine) Scott Holland, PhD Research Foundation, OH Leroy Hood, MD, PhD Institute for Systems Biology, WA Sjögren’s Syndrome COLLABORATOR ORGANIZATION John Van Horn, PhD USC (Neurology) Daniel Arkfeld, MD USC (Department of Medicine) USC (Industrial and Systems Stratos Christianakis, MD USC (Department of Medicine) Carl Kesselman, PhD Engineering) Stan Louie, PhD USC (School of Pharmacy) Richard Leahy, PhD USC (Electrical Engineering) Curtis Okamoto, PhD USC (School of Pharmacy) Robert Scott Mackin, PhD UCSF School of Medicine J. Andrew MacKay, PhD USC (School of Pharmacy) Geoffrey T. Manley, MD, PhD UCSF School of Medicine USC (Department of Preventive Tom Nichols, PhD University of Warwick, United Kingdom Wendy Mack, PhD Medicine) Yuko Y. Palesch, PhD Medical University of South Carolina, SC Kathleen Rodgers, PhD USC (School of Pharmacy) Nathan Price, PhD Institute for Systems Biology, WA William Stohl, MD, PhD USC (Department of Medicine) Bruce Rosen, MD, PhD Massachusetts General Hospital, MA Driss Zoukhri, PhD Tufts University School of Dentistry, MA Howard Rosen, MD USCF Memory and Aging Center
27 Arnold Michels
Choroidal Melanoma
OCULAR HISTORY Diagnosed with a choroidal melanoma after continuous retinal issues, detachments and bleeding.
TREATMENT Patient decided to undergo plaque brachytherapy (radiation implant) Arnold enjoys playing with his grandchildren, Olivia and Colin. to save the eye, regardless of impact on vision. Losing an eye to cancer was a real possibility for Arnold Michels. After a long and complicated history of retinal issues, detachments OUTCOME and bleeding in his left eye, he finally learned why: he had choroidal Cancer controlled. Tumor regressing. melanoma — eye cancer. No observable metastatic disease. As an avid outdoorsman and photographer, Arnold first thought that he Left eye preserved with vision loss. would have to abandon his passion for hiking and introducing children to nature as a volunteer. Without vision, he could not navigate the terrain.
After five difficult surgeries on his eye, Arnold came to the USC Roski Eye Institute with a specific goal. Already blind in his left eye, he wanted to avoid its removal. To achieve this goal, surgeons performed a long, complex surgery in which they implanted a device that would precisely target the tumor with radiation.
The procedure was a success. Arnold’s cancer is under control, the Retinal photograph of eye with a tumor is shrinking and he has no sign of metastatic disease. Best of all, malignant choroidal melanoma. he is delighted to still have his left eye. “They went above and beyond all my expectations,” Arnold says.
Jesse Berry, MD, performed the surgery that saved Arnold’s left eye from cancer. Choroidal melanoma in the left eye after trans-retinal prognostic biopsy.
28 usceye.org They went above and beyond all my expectations. “ Arnold Michels ”
29 SERVING THE UNDERSERVED AT LAC+USC
The USC Roski Eye Institute is the exclusive provider of vision care at the LAC+USC Medical Center, the hub of a Los Angeles County health system that serves 10 million people. This presents multiple opportunities to provide a wide array of complex, clinical care that profoundly enhances people’s lives.
Recycle Vision Recycle Vision, started by USC’s Jesse Berry, MD, collects used eyeglasses and logs prescriptions. They then match prescriptions and give eyeglasses to patients who otherwise might not afford them. 55% Eyeglass Prescriptions Not Filled 67% Patients Concerned about Cost 300+ Pairs of Used Eyeglasses Provided
USC Roski Eye Institute residents, shown with ophthalmologist Jesse Berry, MD, follow patients longitudinally throughout their residencies at LAC+USC for an exceptional clinical and personal experience.
LAC+USC Ophthalmology 200 Patients per day 10 Surgeries per day The 600-bed Los Angeles County + USC Medical Center is one of the largest public hospitals in the country 5 Ophthalmology subspecialties and one of the premier academic teaching hospitals in the nation.
30 usceye.org RESEARCH
Vulnerable patients will benefit from greater access to eye care as new studies are launched and new healthcare policies are adopted.
IMPROVING ACCESS, QUALITY AND EFFICIENCY
The USC Roski Eye Institute is at the heart of USC’s latest efforts to tackle the challenges of healthcare system reform. Seth Seabury, PhD The newly established Keck-Schaeffer Initiative for Population Health Policy is led by Seth Seabury, PhD, associate professor in the USC Department of Ophthalmology and associate professor of research in the Leonard D. Schaeffer “ Center for Health Policy and Economics. Its mission is to identify evidence-based We will strive policies that improve access to care for underserved populations and increase the to use cutting- value of the services provided. edge research to This collaboration between the Keck School of Medicine of USC and the USC Schaeffer Center will be the catalyst for new research and educational studies for help improve improving population health and healthcare delivery. the health of vulnerable populations.”
31 INSIGHT Preserving Sight
The USC Roski Eye Institute champions preventive care, engages in partnerships and inspires philanthropy in our mission to eliminate visual impairment and blindness.
32 usceye.org PRESERVING SIGHT
IMPROVING
IN LifeRURAL India
Clockwise from top: Srikiran Institute of Ophthalmology; Chandrasekhar Sankurathri, MD; cataract patients on post-op day one; 3rd-year resident Philip Storey, MD, MPH, examines a patient; Storey and USC Assistant Professor Jesse Berry, MD, during a rotation in India.
Chandrasekhar Sankurathri, MD, visiting professor of ophthalmology, has dedicated his life to saving the vision of people who would PRESERVING VISION otherwise go blind. In its 23 years, the nonprofit In 1989, he established the nonprofit Sankurathi Foundation as a Srikiran Institute of Ophthalmology memorial to his wife, son and daughter who were killed in an Air India has achieved an impressive terrorist bombing on July 23, 1985. The mission was to “empower the record of service: poor through better education, eye care and timely help to the needy.” His mission expanded in 1993 with the opening of the Srikiran Institute of 2,360 screening camps for adults Ophthalmology, named after his son. The eye hospital provides accessible 1,073 screening camps for and affordable services to all “irrespective of race, religion, caste, age, children sex and other socioeconomic factors.” 2,170,855 outpatient visits From conducting preventive screenings to providing complex procedures, 208,577 surgeries often without charge, the hospital is improving the lives of people in rural India.
33 SHEDDING LIGHT TO EYE PREVENT BLINDNESS HEALTH IN New National Eye Institute studies led by Rohit Varma, MD, AMERICA MPH, suggest that vision screening for refractive error and early eye disease may reduce or prevent a high proportion 2050 of individuals from experiencing unnecessary vision loss FORECAST and blindness. These findings will guide clinical care and health policy designed to protect and preserve the vision of all Americans.
VISUAL IMPAIRMENT AND BLINDNESS IN THE UNITED STATES, 2015-2050
VISUAL BLINDNESS VISUAL IMPAIRMENT IMPAIRMENT AGE 40+ & BLINDNESS AGE 40+ AGE 40+ FROM UNCORRECTED VISION
6.95 2.01 16.4 MILLION MILLION MILLION 8.2 3.22 1.02 MILLION MILLION MILLION 529K 290K
2015 2050 2015 2050 2015 2050
THE NUMBER OF CASES IS EXPECTED TO DOUBLE BY 2050 * VISUAL IMPAIRMENT BLINDNESS
VISUAL IMPAIRMENT AND BLINDNESS BY GENDER, 2015-2050
BLINDNESS VISUAL IMPAIRMENT
1.05 1.84 3.94 520K MILLION MILLION MILLION 1.38 3.02 490K 960K MILLION MILLION
2015 2050 2015 2050
BURDEN OF BLINDNESS AND VISUAL IMPAIRMENT AMONG WOMEN IS HIGHER FEMALE MALE AND EXPECTED TO INCREASE *
34 usceye.org PRESERVING SIGHT
VISUAL IMPAIRMENT AND BLINDNESS BY RACIAL/ETHNIC GROUPS, 2015-2050
VISUAL IMPAIRMENT 2015 2050 BLINDNESS 2015 2050
2.3 3.9 1.1 NON-HISPANIC WHITE MILLION MILLION NON - HISPANIC WHITE 700K MILLION 1.1 AFRICAN AMERICAN 500K MILLION AFRICAN AMERICAN 200K 500K 1.4 LATINO 300K MILLION LATINO 100K 400K ASIAN AND OTHER 100K 500K ASIAN AND OTHER 20K 50K
THE LARGEST BURDEN WILL BE AMONG NON-HISPANIC WHITES AND IS EXPECTED TO INCREASE AMONG OTHER GROUPS *
TWO STUDIES ON ADDITIONAL POPULATIONS PROVIDE MAJOR INSIGHTS The largest U.S. epidemiological studies ever conducted on Chinese Americans and Latinos were published in 2016 by the USC Roski Eye Institute.
CHINESE AMERICAN EYE STUDY LOS ANGELES LATINO EYE STUDY KEY FINDINGS KEY FINDINGS • Greater prevalence of neovascular (wet) age- • Significantly lower quality of life for those with related macular degeneration severe age-related macular degeneration in one • Three times higher prevalence of visual or both eyes impairment among those with type II diabetes • Less access and utilization of health care may than those without diabetes contribute to quality of life decline
* For complete findings please refer to: Visual Impairment and Blindness in Adults in the United States: Demographic and Geographic Variations from 2015 to 2050. JAMA Ophthalmol. PMID: 27197072.
35 GIVING GENEROUSLY TO A DVANCE VISION CARE The vibrant paintings by Gayle Garner Roski, an accomplished watercolorist, have been exhibited in museums and galleries from California to Scotland.
Gayle and Edward Roski took a bold step in 2016 to improve vision and end blindness. They made a landmark $25 million gift to endow and name the USC Gayle and Edward Roski Eye Institute at Keck Medicine of USC.
Their generosity was inspired by personal experiences and deep concern for others. After Gayle Garner Roski, a plein-air watercolorist, received cataract treatment at the USC Eye Institute, her ability to see color and light values improved dramatically. To help others fully enjoy the gift of sight, they decided to make a major gift.
Their exceptional support will enable the USC Roski Eye Institute to continue its powerful influence on vision care, research and education around the world.
Edward and Gayle Roski accelerated the advancement of clinical ophthalmology and vision science through their landmark gift.
36 usceye.org INSIGHT Clinical Education
The USC Roski Eye Institute equips and emboldens generations of clinician-scientists who revolutionize the diagnosis and treatment of eye conditions and diseases.
37 Joseph Cocozza, assistant professor of research, instructs students in the new Ophthalmic Technician Education Program.
“OTEP joins only 14 centers ADVANCING nationwide offering this OPHTHALMIC specialized training.” TECHNICIAN EDUCATION The USC Roski Eye Institute established a new Ophthalmic Technician Education Program (OTEP), joining only 14 centers nationwide offering this specialized training.
OTEP is a certificate program that integrates core academic knowledge with clinical and occupational skill mastery. It includes classroom and clinical experiences that prepare graduates to assist ophthalmologists in the prevention, detection and treatment of vision impairments in private practice offices, hospitals and community-based clinics. OTEP students have clinical rotations at the USC Roski Eye Institute, LAC+USC Medical Center and Children’s Hospital Los Angeles.
Joseph Cocozza, PhD, The U.S. Department of Labor projects a 21 percent increase in co-directs the ophthalmic medical positions by 2021. The new program is designed to Ophthalmic Technician Education Program. help meet this urgent need.
38 usceye.org CLINICAL EDUCATION
SHARPENING SKILLS FOR OCULOFACIAL
SURGEONS WORLDWIDE Sandy Zhang-Nunes, MD, organized the oculofacial surgical skills course with The USC oculofacial surgical skills course brought together renowned faculty, USC Roski Eye Institute staff. fellows, and residents in oculoplastics, ophthalmology, ENT, and plastic surgery to learn from each other. American Society of Ophthalmic Plastic and Reconstructive Surgery (ASOPRS) fellows from around the United States, as well as visiting scholars from around the world participated. After brief lectures, expert faculty rotated between fully equipped surgical stations that included surgical oculoplastic instruments, an endoscope, a drill, ultrasonic
aspirator, plating material and a fresh cadaver head. Attendees learned new Michael Burnstine, MD Director of the Oculofacial approaches and practiced valuable skills that will improve patient care. plastics fellowship program.
Participants from all over the world came together to share valuable skills.
39 The PROSE procedure was a game changer. My eyes “ are no longer miserable all the time. Jeremy Falk ”
40 usceye.org Jeremy Falk
Stevens-Johnson Syndrome
OCULAR HISTORY Developed Stevens-Johnson Syndrome after taking Bactrim to treat an infection, resulting in eye pain, dryness, light sensitivity and irritation. Jeremy’s active lifestyle includes cycling and distance running. TREATMENT Extreme light sensitivity and sore, bloodshot eyes made life difficult Received custom-designed PROSE for Jeremy Falk, an independent businessman, distance runner and (prosthetic replacement of the ocular self-proclaimed “power nerd.” A terrible reaction to an antibiotic left surface ecosystem) scleral devices. him with chronic, severe dry eyes. After years of seeking relief, he OUTCOME finally found it at the USC Roski Eye Institute. Improved comfort, vision and quality To compensate for the lack of tears, Gloria Chiu, OD, FAAO, FSLS, of life. initiated Boston Sight® PROSE (prosthetic replacement of the ocular system) treatment, available at only 12 sites nationwide. Now Jeremy’s eyes are protected and kept moist by a set of made-to-specification removable scleral devices that cover the entire outer surface of his eyes.
Initially, Jeremy was anxious about placing the lenses on his eyes. After some training, coaching and practice, he mastered the process. The gas-permeable PROSE device creates “Dr. Chiu was patient, gentle, professional and no nonsense,” Jeremy a smooth optical surface above the cornea and bathes the ocular surface says. “She changed my life.” with a reservoir of sterile saline. (Image courtesy of Boston Sight®.) Jeremy’s eyes are much better, and life has returned to normal. Armed with his “rock ‘n roll eyeball kit,” he faces the world with greater confidence and a brighter outlook.
Gloria Chiu, OD, FAAO, FSLS, prescribed and fitted the PROSE lenses that provide relief for Jeremy’s eye condition.
With training, patients eventually master application and use of the PROSE device.
41 SHARING ADVICE WITH FUTURE LEADERS
A FORMER USC RESIDENT RETURNS TO USC ROSKI EYE Sahar Bedrood, MD, PhD INSTITUTE WITH INSIGHTS FOR SUCCESS. Assistant Professor of Clinical Ophthalmology
MEDICAL SCHOOL| MD/PHD On Career Choice Keck School of Medicine of USC I took a biochemistry class at Francisco Bravo Medical Magnet High OPHTHALMOLOGY RESIDENCY “School, taught by USC’s Dr. Cocozza, that focused on the chemistry LAC+USC Medical Center
behind ophthalmology. I knew from that point that ophthalmology GLAUCOMA FELLOWSHIP was what I wanted to do. The Johns Hopkins Wilmer Eye Institute ” RESEARCH • Structural characteristics of the optic nerve On Residency Training lamina cribrosa My advice is to find a program that is best suited to your individual needs. • Glaucoma disruption of patients’ daily “If you’re looking for strong clinical and surgical training, and to be an functional ability innovative leader, then USC is the place for you. PROFESSIONAL ORGANIZATIONS ” • American Glaucoma Society USC has one of the most challenging ophthalmology residency programs • American Society of Cataract and Refractive Surgery “in the country, hands down. I left the program so confident, so prepared • Los Angeles Society of Ophthalmology to take on any challenge that came my way.” • Society of Heed Fellows AWARDS On USC Faculty • Society of Heed Fellows Fellowship Award • National Eye Institute ARVO Award A very strong teaching component with LAC+USC Medical Center • P.E.O. Scholar Award “allows faculty to play a big role in the training and mentorship of • Order of the Arete residents and fellows.” • Remarkable Women of USC Award
42 usceye.org CLINICAL EDUCATION
41ST Anniversary CELEBRATING Symposium Distinguished Ophthalmologists
ADVANCEMENTS IN Nisa Acharya, MD Director, Uveitis Service and Uveitis Fellowship, F.I. Proctor Foundation and OPHTHALMOLOGY Professor of Ophthalmology, University of California, San Francisco Nearly 400 ophthalmologists and optometrists attended the USC Roski Eye Pravin U. Dugel, MD Institute 41st Anniversary Symposium at the Huntington Library in Pasadena. Clinical Professor, USC Roski Eye Institute, Keck School of Medicine of USC, Managing The event’s distinguished speakers provided presentations on every subspecialty Partner, Retinal Consultants of Arizona and of ophthalmology. Founding Member, Spectra Eye Institute Jonathan M. Holmes, MD Joseph E. and Rose Marie Green Professor of Visual Sciences and Professor of Ophthalmology and Former Chair, Department of Ophthalmology, College of Medicine, Mayo Clinic Mark S. Humayun, MD, PhD Cornelius J. Pings Chair in Biomedical Sciences, Professor of Ophthalmology, Biomedical Engineering and Cell and Neurobiology, Director of the USC Institute USC Roski Eye Institute faculty members at the 41ST Anniversary Symposium. for Biomedical Therapeutics and Co- Director of the USC Roski Eye Institute, Keck School of Medicine of USC Sean Ianchulev, MD, MPH Chief Medical Officer and Vice President, Medical Affairs and Business Development, Transcend Medical Guy G. Massry, MD Clinical Professor of Ophthalmology, Keck School of Medicine of USC Neil R. Miller, MD Frank B. Walsh Professor of Neuro- Ophthalmology and Professor of Ophthalmology, Neurology and Neurosurgery, Johns Hopkins Medical Institutions J. Bradley Randleman, MD Professor of Ophthalmology and Director of Cornea, External Disease and Refractive Surgery, USC Roski Eye Institute, Keck School of Medicine of USC J. Timothy Stout, MD, PhD, MBA Director, Cullen Eye Institute and Chair, Department of Ophthalmology, Baylor College of Medicine Rohit Varma, MD, MPH, left, presented Preeminent vision experts shared their work with a Young Hee Yoon, MD, PhD Neil R. Miller, MD, the Frank B. Walsh Professor capacity crowd. of Neuro-Ophthalmology and professor of Professor of Ophthalmology, Asan Medical ophthalmology, neurology, and neurosurgery, Center, University of Ulsan, South Korea Johns Hopkins Medical Institutions, with the USC Roski Eye Institute Laureate Award for 2016.
43 PREPARING AND INSPIRING THE NEXT LEADERS NEW FULL-TIME FACULTY FOR 2016 Name Title Specialty Sahar Bedrood, MD, PhD Assistant Professor of Clinical Ophthalmology Glaucoma
Comprehensive Eye Care in Primary Care, Ocular Kent Nguyen, OD, FAAO Assistant Professor of Clinical Ophthalmology Disease, and Contact Lenses
Corneal and External Diseases and Corneal J. Bradley Randleman, MD Professor of Clinical Ophthalmology Cross-Linking
Associate Professor of Research Seth Seabury, PhD Ophthalmology Health Policy and Economics Ophthalmology
Mahnaz Shahidi, PhD Professor of Ophthalmology Retinal Imaging
Lan Yue, PhD Assistant Professor of Research Ophthalmology Retinal Prosthesis
Professor of Ophthalmology, Biomedical Biomedical Engineering Ophthalmic Elastography, Qifa Zhou, PhD Engineering Ultrasonic Retinal and Brain Stimulation
NEW OPPORTUNITIES FOR 2016 Each year, positions open for six new residents and eight new fellows. Hundreds of outstanding candidates apply to train at the USC Department of Ophthalmology.
VOLUNTARY RESIDENT ROTATION IN INDIA NEW FELLOWSHIP IN EYE PATHOLOGY Residents will complete two-week, on-site comprehensive Fellows have extraordinary learning opportunities at USC’s and subspecialty clinics at the Srikiran Institute of ophthalmic molecular and immuno-pathology laboratory, Ophthalmology in rural Andhra Pradesh, India. one of the few in the United States.
The USC Roski Eye Institute residents and fellow train in four diverse and highly acute clinical and surgical settings: the USC Roski Eye Institute, Children’s Hospital Los Angeles, Los Angeles County Hospital (LAC+USC Medical Center) and Veterans Administration Downtown Los Angeles Medical Center.
44 usceye.org CLINICAL EDUCATION
INSPIRING CLINICAL EXCELLENCE THROUGH GRAND
THE USC ROSKI EYE INSTITUTE PRESENTS RESIDENTS WITH ROUNDSCOMPLEX CLINICAL CHALLENGES, AS DEMONSTRATED BY THE CASE “DOUBLE TROUBLE” SUMMARIZED BELOW. Vivek Patel, MD, residency program director (left), and first-year resident Debarshi Mustafi, worked together on the “Double Trouble” case.
HISTORY ADDITIONAL INVESTIGATIONS THIS CASE ILLUSTRATES THE IMPORTANCE OF THE CEREBRAL • Hispanic female, age 66, presents to • MRI brain with and without contrast VENOUS SYSTEM IN THE REGULATION the emergency department with was obtained to better characterize OF CSF PRESSURE AND NEUROIMAGING worsening blurred vision over several the etiology of the elevated ICP. FEATURES THAT CAN SUPPORT A weeks and a one-year history of (See Figures 1 and 2.) SUSPICION OF ELEVATED ICP. intermittent binocular diplopia, pulsating left-ear pain and tinnitus. DIAGNOSIS • PMH: HTN, DM Type 2, Dyslipidemia • Paraganglioma causing compression Hyperthyroidism. of the left internal jugular vein. • ROS negative for headaches, nausea • Jugular venous obstruction resulted in or sudden loss of vision. impaired CSF absorption, leading to elevated ICP. EXAM FINDINGS • Sufficiently compartmentalized • BCVA 20/20 OD, 20/30 OS, IOP WNL, no CSF pressure may allow some Figure 1. Axial (left) and sagittal (right) cuts RAPD, Ishihara color plates normal OU. cases of elevated ICP to present demonstrate an absence of flattening of the back of the globe or tortuosity of the optic nerve • Anterior segment exam on slit lamp only without papilledema. that can be seen with elevated ICP. notable for 2+ NSC of the lens OU. TREATMENT • Dilated fundus exam: normal appearing • Since malignant behavior is only seen in optic nerves with CDR 0.4 without 4% of jugulotympanic paragangliomas, evidence of swelling or atrophy. treatment options include observation, DIFFERENTIAL DIAGNOSIS surgical resection with preoperative embolization, radiotherapy and • Bilaterally swollen optic nerves with near radiosurgery. normal function. Elevated intercranial pressure (ICP) would suggest obstruction • Patient was seen eight weeks after initial Figure 2. MRI brain post-contrast, sequential visit. Stable nature of the symptoms led axial T1 images reveal an avidly enhancing or abnormality. Normal ICP would suggest mass (blue arrow) measuring 23 x 15 x 24 diabetic papillopathy, optic perineuritis us to monitor her with dilated fundus mm (TV x AP x CC) within and expanding the exams and Humphrey visual fields at left jugular foramen, and enveloping the left or hypertensive papillopathy. internal jugular vein (red arrow). subsequent visits. She is also being followed by neurology and ENT services as an outpatient for possible surgical intervention if symptoms worsen.
45 USC ROSKI EYE INSTITUTE RESIDENTS AND FELLOWS 2016-17
Residents PROGRAM Six exceptional residents are recruited each year from hundreds of applicants. LEADERSHIP Third Year
Jiun L. Do, MD, PhD Stavros Moysidis, MD Billy Pan, MD Kelly Rue, MD Grace Shih, MD Philip Storey, Co-Chief Resident MD, MPH Co-Chief Resident Second Year
from top left to right
Rohit Varma, MD, MPH Director, USC Roski Eye Institute Vivek Patel, MD Residency Program Director Walid F. Abdallah, On-Tat Lee, MD Natasha Naik, MD Ananth Sastry, MD Brandon Wong, MD Arman Zaman, MD MD, PhD Jesse Berry, MD Associate Residency First Year Program Director
Malvin Anders, MD Chief of Ophthalmology, LAC+USC Medical Center
Christine Greer, Arezu Haghighi, MD Ramon Lee, MD Debarshi Mustafi, Luv Patel, MD Nadim Rayess, MD MD, MS MD, PhD
Fellows and Clinical Instructors The USC Roski Eye Institute offers clinical fellowship training in six subspecialty areas, including cornea and external disease, glaucoma, neuro-ophthalmology, ophthalmic Brian Do, MD Kimberly Gokoffski, Humair Khan, MD Julie Kwon, MD Jessica Maslin, MD plastic surgery, retina and uveitis. Vitreoretinal MD, PhD Cornea Medical Retina Glaucoma Neuro-Ophthalmology Informal research fellowships are also awarded by each service and laboratory independently. The USC Roski Eye Institute attracts promising academic ophthalmologists from around the world who spend one or two years participating in research programs. Many return to their Helen Merritt, MD Julia Nemiroff, MD Nishant Soni, MD Jeffrey Tan, MD Brian Toy, MD home countries where they assume positions Oculo-Facial Medical Retina Cornea Vitreoretinal Vitreoretinal of national or international leadership. Plastics
46 usceye.org CLINICAL EDUCATION USC ROSKI EYE INSTITUTE FACULTY
Hossein Ameri, Sahar Bedrood, Jesse Berry, MD Mark Borchert, MD Angela Buffenn, Michael Burnstine, Gloria Chiu, Farzana Choudhury, MD, PhD MD, PhD Assistant Professor Associate Professor MD, MPH MD OD, FAAO, FSLS MBBS, MPH, PhD Assistant Professor Assistant Professor Assistant Professor Clinical Professor Assistant Professor Assistant Professor
David Cobrinik, Joseph Cocozza, PhD Cheryl Craft, PhD Steven Dresner, MD Charles Flowers Jr., MD Henry Fong, PhD Sarah Hamm- J. Martin Heur, MD, PhD Assistant Professor Professor Clinical Professor Associate Professor Associate Professor Alvarez, PhD MD, PhD Associate Professor Professor Associate Professor
Mark Humayun, Veronica Isozaki, Shinwu Jeong, PhD Xuejuan Jiang, PhD Amir Kashani, Jonathan Kim, MD Tali Kolin, MD Linda Lam, MD, MBA MD, PhD OD, FAAO Assistant Professor Assistant Professor MD, PhD Associate Professor Adjunct Associate Associate Professor Professor Assistant Professor Assistant Professor Professor
Carlos Lastra Gonzalez, MD Thomas Lee, MD Debbie Mitra, PhD Karen Morgan, MD Andrew Moshfeghi, Arlanna Moshfeghi, A. Linn Murphree, MD Sudha Nallasamy, MD Clinical Research Associate Professor Assistant Professor Clinical Professor MD, MBA MD, MPH Professor Assistant Professor Instructor Associate Professor Assistant Professor
Kent Nguyen, OD, FAAO Vivek Patel, MD Carmen Puliafito, J. Bradley Narsing Rao, MD Bibiana Reiser, Alena Reznik, MD Grace Richter, Assistant Professor Associate Professor MD, MBA Randleman, MD Professor MD, MS Assistant Professor MD, MPH Professor Professor Assistant Professor Assistant Professor
David Richardson, MD Damien Rodger, Seth Seabury, PhD Mahnaz Shahidi, PhD Jonathan Song, MD Biju Thomas, PhD Paul Thompson, PhD Arthur Toga, PhD Adjunct Assistant MD, PhD Associate Professor Professor Associate Professor Assistant Professor Professor Provost Professor Professor Assistant Professor
Lernik Torossian Rohit Varma, MD, MPH James Weiland, PhD Andrew Weitz, PhD John Whalen, PhD Lan Yue, PhD Sandy Zhang-Nunes, MD Qifa Zhou, PhD OD, FAAO Professor Professor Assistant Professor Assistant Professor Assistant Professor Assistant Professor Professor Assistant Professor 47 USC ROSKI EYE INSTITUTE VOLUNTEER FACULTY
John Affeldt, MD Soma Agarwal, MD Rajat Agrawal, Selwa Al-Hazzaa, Malvin Anders, MD Richard Apt, MD Gregory Bearman, Joseph Boban, MD MD, MS MD PhD
Swaraj Bose, MD Gerald Bowns, MD David Boyer, MD Brian Brown, MD Gerald Chader, Grace Chang, MD, Lawrence Chong, Michael Colvard, PhD PhD MD MD
Lauren Daskivich, Kenneth Diddie, Pravin Dugel, MD Gregg Feinerman, Wolfgang Fink, David Fuerst, MD Sam Goldberger, MD David Goldenberg, MD MD MD PhD MD
Ronald Green, MD Farhad Hafezi, Houman Hemmati, Lars Hertzog, MD Leif Hertzog, MD Alan Horsager, PhD Lynn Huang, MD, John Hwang, MD MD, PhD MD, PhD MPH
Sean Ianchulev, Karim Jamal, MD Joseph Kim, MD Michael Koss, MD Derek Kunimoto, James Lambert, Phillip Phuc Le, Grant Lee, MD MD, MPH MD PhD MD, PhD
Garlan Lo, MD Jonathan Macy, MD Alan Mandelberg, Alfred Marrone, MD Guy Massry, MD William May, MD Douglas McCreery, Raghu Murthy, MD MD PhD
48 usceye.org CLINICAL EDUCATION
USC ROSKI EYE INSTITUTE VOLUNTEER FACULTY
Kami Parsa, MD Artin Petrossians, Dante Pieramici, Paul Prendiville, Harold Reaves, MD Warren Reingold, Arvind Saini, MD James Salz, MD PhD MD MD MD
David Samimi, MD Steve Schallhorn, Donald Schwartz, Donald Serafano, John Shammas, Marc Shomer, MD, Holly Spanggord, Warren Stout, MD MD MD, MPA MD MD PhD MD
Erik Tu, MD Paul Urrea, MD, Lee Wan, MD Kenneth Wright, David Yu, MD Christopher MPH MD Zoumalan, MD
49 INSIGHT 2016 Faculty Publications
Faculty members at USC Roski Eye Institute discover and disseminate vital information that improves lives by contributing to the advancement of ophthalmology and vision science.
1. Abdallah WF, Louie SG, Zhang Y, Rodgers KE, Sivok MM, Van Eijk KR, Van Erp TG, Van Rooij D, Walton E, R, Schofield PR, Sigurdsson S, Simmons A, Singleton E, G Sd, Humayun MS. Norleu3a(1-7) Accelerates Westlye LT, Whelan CD, Windham BG, Winkler AM, A, Sisodiya SM, Smith C, Smoller JW, Soininen Clear Corneal Full Thickness Wound Healing. Invest Woldehawariat G, Wolf C, Wolfers T, Xu B, Yanek LR, H, Srikanth V, Steen VM, Stott DJ, Sussmann JE, Ophthalmol Vis Sci. 2016 Apr 1;57(4):2187-94. Yang J, Zijdenbos A, Zwiers MP, Agartz I, Aggarwal Thalamuthu A, Tiemeier H, Toga AW, Traynor BJ, NT, Almasy L, Ames D, Amouyel P, Andreassen Troncoso J, Turner JA, Tzourio C, Uitterlinden AG, 2. Adam MK, Rayess N, Rahimy E, Maguire JI, Hsu OA, Arepalli S, Assareh AA, Barral S, Bastin ME, Hernandez MC, Van der Brug M, Van der Lugt A, Van J. Radial Versus Raster Spectral-Domain Optical Becker DM, Becker JT, Bennett DA, Blangero J, van der Wee NJ, Van Duijn CM, Van Haren NE, Van TED, Coherence Tomography Scan Patterns for Detection Bokhoven H, Boomsma DI, Brodaty H, Brouwer RM, Van Tol MJ, Vardarajan BN, Veltman DJ, Vernooij of Macular Fluid in Neovascular Age-Related Brunner HG, Buckner RL, Buitelaar JK, Bulayeva MW, Volzke H, Walter H, Wardlaw JM, Wassink TH, Macular Degeneration. Br J Ophthalmol. 2016 KB, Cahn W, Calhoun VD, Cannon DM, Cavalleri GL, Weale ME, Weinberger DR, Weiner MW, Wen W, Apr;100(4):491-4. Chen C, Cheng CY, Cichon S, Cookson MR, Corvin Westman E, White T, Wong TY, Wright CB, Zielke 3. Adams HH, Hibar DP, Chouraki V, Stein JL, Nyquist A, Crespo-Facorro B, Curran JE, Czisch M, Dale AM, HR, Zonderman AB, Deary IJ, DeCarli C, Schmidt PA, Renteria ME, Trompet S, Arias-Vasquez A, Davies GE, De Geus EJ, De Jager PL, de Zubicaray H, Martin NG, De Craen AJ, Wright MJ, Launer Seshadri S, Desrivieres S, Beecham AH, Jahanshad GI, Delanty N, Depondt C, DeStefano AL, Dillman LJ, Schumann G, Fornage M, Franke B, Debette N, Wittfeld K, Van der Lee SJ, Abramovic L, Alhusaini A, Djurovic S, Donohoe G, Drevets WC, Duggirala S, Medland SE, Ikram MA, Thompson PM. Novel S, Amin N, Andersson M, Arfanakis K, Aribisala R, Dyer TD, Erk S, Espeseth T, Evans DA, Fedko IO, Genetic Loci Underlying Human Intracranial Volume BS, Armstrong NJ, Athanasiu L, Axelsson T, Beiser Fernandez G, Ferrucci L, Fisher SE, Fleischman DA, Identified through Genome-Wide Association. Nat A, Bernard M, Bis JC, Blanken LM, Blanton SH, Ford I, Foroud TM, Fox PT, Francks C, Fukunaga M, Neurosci. 2016 Dec;19(12):1569-82. Bohlken MM, Boks MP, Bralten J, Brickman AM, Gibbs JR, Glahn DC, Gollub RL, Goring HH, Grabe 4. Al Shamrani M, Al Hati K, Alkatan H, Alharby M, Carmichael O, Chakravarty MM, Chauhan G, Chen HJ, Green RC, Gruber O, Gudnason V, Guelfi S, Jastaneiah S, Song J, Edward DP. Pathological and Q, Ching CR, Cuellar-Partida G, Braber AD, Doan NT, Hansell NK, Hardy J, Hartman CA, Hashimoto R, Immunohistochemical Alterations of the Cornea Ehrlich S, Filippi I, Ge T, Giddaluru S, Goldman AL, Hegenscheid K, Heinz A, Le Hellard S, Hernandez in Congenital Corneal Opacification Secondary to Gottesman RF, Greven CU, Grimm O, Griswold ME, DG, Heslenfeld DJ, Ho BC, Hoekstra PJ, Hoffmann Primary Congenital Glaucoma and Peters Anomaly. Guadalupe T, Hass J, Haukvik UK, Hilal S, Hofer E, W, Hofman A, Holsboer F, Homuth G, Hosten N, Cornea. 2016 Feb;35(2):226-33. 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Minimally Invasive 179. Seabury SA. Letter. J Manag Care Spec Pharm. 2016 Patterns in Endophthalmitis Following Intravitreal Glaucoma Surgery: Current Status and Future Nov;22(11):1222. Injection. Graefes Arch Clin Exp Ophthalmol. 2016 Prospects. Clin Ophthalmol. 2016;10:189-206. Feb;254(2):235-42. 180. Shafrin J, Ganguli A, Gonzalez YS, Shim JJ, Seabury 165. Richter GM, Zhang X, Tan O, Francis BA, Chopra SA. Geographic Variation in the Quality and Cost of 194. Storey P, Philander SA, Ter-Zakarian A, Rao V, Greenfield DS, Varma R, Schuman JS, Huang Care for Patients with Rheumatoid Arthritis. J Manag NA, Rodger DC. Ultra-Wide-Field Fluorescein D. Regression Analysis of Optical Coherence Care Spec Pharm. 2016 Dec;22(12):1472-81. Angiography in Microscopic Polyangiitis. Case Rep Tomography Disc Variables for Glaucoma Diagnosis. Ophthalmol Med. 2016;2016:9834684. J Glaucoma. 2016 Aug;25(8):634-42. 181. Shan ZY, Vinkhuyzen AA, Thompson PM, McMahon KL, Blokland GA, de Zubicaray GI, Calhoun V, 195. Storey P, Kim EL, Patel V. Ptosis, Miosis, and 166. Riedel BC, Thompson PM, Brinton RD. Age, Apoe Martin NG, Visscher PM, Wright MJ, Reutens DC. Intermittent Esotropia Following Pituitary Adenoma and Sex: Triad of Risk of Alzheimer’s Disease. J Genes Influence the Amplitude and Timing of Brain Resection. JAMA Ophthalmol. 2016 Aug 1;134(8):941-2. Steroid Biochem Mol Biol. 2016 Jun;160:134-47. Hemodynamic Responses. Neuroimage. 2016 Jan 196. Storey P, Murchison AP, Pizzi LT, Hark LA, 167. Rodger DC, Kim EL, Rao NA. Ophthalmomyiasis 1;124(Pt A):663-71. Dai Y, Leiby BE, Haller JA. Impact of Physician Interna. Ophthalmology. 2016 Feb;123(2):247. 182. Shen KK, Dore V, Rose S, Fripp J, McMahon KL, de Communication on Diabetic Eye Examination 168. Roussotte FF, Narr KL, Small GW, Thompson PM. Zubicaray GI, Martin NG, Thompson PM, Wright Adherence: Results from a Retrospective Cohort The C677t Variant in Mthfr Modulates Associations MJ, Salvado O. Heritability and Genetic Correlation Analysis. Retina. 2016 Jan;36(1):20-7. between Blood-Based and Cerebrospinal Fluid between the Cerebral Cortex and Associated 197. Storey P, Ter-Zakarian A, Rao N, Rodger DC. Severe Biomarkers of Neurodegeneration. Neuroreport. 2016 White Matter Connections. Hum Brain Mapp. 2016 Bilateral Retinal Vascular Occlusion as First Presentation Aug 17;27(12):948-51. Jun;37(6):2331-47. of Systemic Lupus Erythematosus and Antiphospholipid 169. Ryabets-Lienhard A, Stewart C, Borchert MS, 183. Shieh E, Lee R, Que C, Srinivasan V, Guo R, DeLuna Syndrome. Retin Cases Brief Rep. 2016 Aug 19. Geffner ME. The Optic Nerve Hypoplasia Spectrum: R, Pandit S, Simavli H, Seevaratnam R, Tsikata E, de Review of the Literature and Clinical Guidelines. Adv Boer J, Chen TC. 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55 198. Su Y, Blazey TM, Owen CJ, Christensen JJ, ID, Leech DI, Mackay EB, Massimino D, Atkinson near Visual Acuity Testing as Inexpensive Screening Friedrichsen K, Joseph-Mathurin N, Wang Q, S, Bacon PJ, Brereton TM, Carvalho L, Clutton- Tools to Detect Referral Warranted Diabetic Eye Hornbeck RC, Ances BM, Snyder AZ, Cash LA, Brock TH, Duck C, Edwards M, Elliott JM, Hall SJ, Disease. Retina. 2016 May;36(5):1000-8. Koeppe RA, Klunk WE, Galasko D, Brickman AM, Harrington R, Pearce-Higgins JW, Hoye TT, Kruuk LE, 220. Toy BC, Schachar IH, Tan GS, Moshfeghi DM. Chronic McDade E, Ringman JM, Thompson PM, Saykin Pemberton JM, Sparks TH, Thompson PM, White I, Vascular Arrest as a Predictor of Bevacizumab AJ, Ghetti B, Sperling RA, Johnson KA, Salloway Winfield IJ, Wanless S. Phenological Sensitivity to Treatment Failure in Retinopathy of Prematurity. SP, Schofield PR, Masters CL, Villemagne VL, Fox Climate across Taxa and Trophic Levels. Nature. 2016 Ophthalmology. 2016 Oct;123(10):2166-75. NC, Forster S, Chen K, Reiman EM, Xiong C, Marcus Jul 14;535(7611):241-5. DS, Weiner MW, Morris JC, Bateman RJ, Benzinger 221. Tsikata E, Lee R, Shieh E, Simavli H, Que CJ, Guo 209. Thomas BB, Zhu D, Zhang L, Thomas PB, Hu Y, TL. Quantitative Amyloid Imaging in Autosomal R, Khoueir Z, de Boer J, Chen TC. Comprehensive Nazari H, Stefanini F, Falabella P, Clegg DO, Hinton Dominant Alzheimer’s Disease: Results from the Dian Three-Dimensional Analysis of the Neuroretinal Rim DR, Humayun MS. Survival and Functionality of Study Group. PLoS One. 2016;11(3):e0152082. in Glaucoma Using High-Density Spectral-Domain Hesc-Derived Retinal Pigment Epithelium Cells Optical Coherence Tomography Volume Scans. Invest 199. Su Y, Blazey TM, Owen CJ, Christensen JJ, Cultured as a Monolayer on Polymer Substrates Ophthalmol Vis Sci. 2016 Oct 1;57(13):5498-508. Friedrichsen K, Joseph-Mathurin N, Wang Q, Transplanted in Rcs Rats. Invest Ophthalmol Vis Sci. Hornbeck RC, Ances BM, Snyder AZ, Cash LA, 2016 May 1;57(6):2877-87. 222. Usui Y, Rao NA, Takase H, Tsubota K, Umazume Koeppe RA, Klunk WE, Galasko D, Brickman AM, K, Diaz-Aguilar D, Kezuka T, Mochizuki M, Goto 210. Thompson PM. Cracking the Brain’s Genetic McDade E, Ringman JM, Thompson PM, Saykin H, Sugita S. Comprehensive Polymerase Chain Code. Proc Natl Acad Sci U S A. 2015 Dec AJ, Ghetti B, Sperling RA, Johnson KA, Salloway Reaction Assay for Detection of Pathogenic DNA in 15;112(50):15269-70. SP, Schofield PR, Masters CL, Villemagne VL, Fox Lymphoproliferative Disorders of the Ocular Adnexa. NC, Forster S, Chen K, Reiman EM, Xiong C, Marcus 211. Thompson PM, Andreassen OA, Arias-Vasquez A, Sci Rep. 2016 Nov 10;6:36621. DS, Weiner MW, Morris JC, Bateman RJ, Benzinger Bearden CE, Boedhoe PS, Brouwer RM, Buckner RL, 223. Varma R, Choudhury F, Chen S, Wu S, Hsu C, Torres TL. Correction: Quantitative Amyloid Imaging Buitelaar JK, Bulayeva KB, Cannon DM, Cohen RA, M, Klein R, Azen SP, McKean-Cowdin R. Prevalence in Autosomal Dominant Alzheimer’s Disease: Conrod PJ, Dale AM, Deary IJ, Dennis EL, de Reus of Age-Related Macular Degeneration in Chinese Results from the Dian Study Group. PLoS One. MA, Desrivieres S, Dima D, Donohoe G, Fisher SE, American Adults: The Chinese American Eye Study. 2016;11(9):e0163669. Fouche JP, Francks C, Frangou S, Franke B, Ganjgahi JAMA Ophthalmol. Epub 2016 Apr 7. H, Garavan H, Glahn DC, Grabe HJ, Guadalupe T, 200. Suner IJ, Bressler NM, Varma R, Dolan CM, Ward Gutman BA, Hashimoto R, Hibar DP, Holland D, 224. Varma R, Jiang X. The Role of Contextual Factors J, Turpcu A. Responsiveness of the National Eye Hoogman M, Pol HE, Hosten N, Jahanshad N, Kelly in Racial/Ethnic Disparities in Eye Care Use. JAMA Institute Visual Function Questionnaire-25 to Visual S, Kochunov P, Kremen WS, Lee PH, Mackey S, Martin Ophthalmol. Epub 2016 Aug 25. Acuity Gains in Patients with Diabetic Macular NG, Mazoyer B, McDonald C, Medland SE, Morey RA, Edema: Evidence from the Ride and Rise Trials. 225. Varma R, Kim JS, Burkemper BS, Wen G, Torres M, Nichols TE, Paus T, Pausova Z, Schmaal L, Schumann Retina. 2016 Sep 23. Hsu C, Choudhury F, Azen SP, McKean-Cowdin R. G, Shen L, Sisodiya SM, Smit DJ, Smoller JW, Stein Prevalence and Causes of Visual Impairment and 201. Tamhankar MA, Lesniak SP, Nallasamy S, Woo JH. DJ, Stein JL, Toro R, Turner JA, van den Heuvel Blindness in Chinese American Adults: The Chinese Tacrolimus-Induced Cerebral Blindness in a Liver MP, van den Heuvel OL, van Erp TG, van Rooij D, American Eye Study. JAMA Ophthalmol. 2016 Jul Transplant Patient. Indian J Ophthalmol. 2016 Veltman DJ, Walter H, Wang Y, Wardlaw JM, Whelan 1;134(7):785-93. Jul;64(7):541. CD, Wright MJ, Ye J. Enigma and the Individual: Predicting Factors That Affect the Brain in 35 226. Varma R, Torres M, McKean-Cowdin R, Rong F, Hsu 202. Tan JJ, George MS, Olmos de Koo LC. The Bandage Countries Worldwide. Neuroimage. Epub 2015 Dec 4. C, Jiang X. Prevalence of Refractive Error in Adult Lens Technique: A Novel Method to Improve Chinese Americans: The Chinese American Eye Intraoperative Visualization and Fluidic Stabilization 212. Thornton Snider J, Seabury SA, Lopez J, McKenzie S, Study. Am J Ophthalmol. 2016 Oct 18. During Vitrectomy in Cases of Penetrating Ocular Goldman DP. Impact of Type 2 Diabetes Medication Trauma. Retina. 2016 Jul;36(7):1395-8. Cost Sharing on Patient Outcomes and Health Plan 227. Varma R, Vajaranant TS, Burkemper B, Wu S, Torres Costs. Am J Manag Care. 2016 Jun;22(6):433-40. M, Hsu C, Choudhury F, McKean-Cowdin R. Visual 203. Tan JJ, Narang S, Purewal B, Langer PD, Blaydon Impairment and Blindness in Adults in the United S, Schwarcz RM, McCormick SA, Kim JY, Walrath 213. Thulasi P, Khandelwal SS, Randleman JB. 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Epithelial Thickness Maps. Invest Ophthalmol Vis Sci. Ultra-High-Field Magnetic Resonance Imaging of the 2016 Jul 1;57(9):Oct544-9. 229. Vaziri K, Schwartz SG, Flynn HW, Jr., Kishor KS, Human Inner Ear at 11.7 Tesla. Otol Neurotol. 2016 Moshfeghi AA. Eye-Related Emergency Department 205. Tao C, Nichols TE, Hua X, Ching CR, Rolls ET, Oct 12. Visits in the United States, 2010. Ophthalmology. Thompson PM, Feng J. Generalized Reduced Rank 216. Toga AW, Neu SC, Bhatt P, Crawford KL, Ashish 2016 Apr;123(4):917-9. Latent Factor Regression for High Dimensional N. The Global Alzheimer’s Association Interactive Tensor Fields, and Neuroimaging-Genetic 230. Vaziri K, Schwartz SG, Kishor KS, Fortun JA, Network. Alzheimers Dement. 2016 Jan;12(1):49-54. Applications. Neuroimage. Epub 2016 Sep 22. Moshfeghi AA, Smiddy WE, Flynn HW, Jr. Rates of 217. Tomkins-Netzer O, Lightman S, Drye L, Kempen J, Reoperation and Retinal Detachment after Macular 206. Tate DF, Wade BS, Velez CS, Drennon AM, Bolzenius Holland GN, Rao NA, Stawell RJ, Vitale A, Jabs DA. Hole Surgery. Ophthalmology. 2016 Jan;123(1):26-31. J, Gutman BA, Thompson PM, Lewis JD, Wilde EA, Outcome of Treatment of Uveitic Macular Edema: Bigler ED, Shenton ME, Ritter JL, York GE. Volumetric 231. Wade BS, Joshi SH, Njau S, Leaver AM, Vasavada The Multicenter Uveitis Steroid Treatment Trial 2-Year and Shape Analyses of Subcortical Structures in M, Woods RP, Gutman BA, Thompson PM, Espinoza Results. Ophthalmology. 2015 Nov;122(11):2351-9. United States Service Members with Mild Traumatic R, Narr KL. Effect of Electroconvulsive Therapy on Brain Injury. J Neurol. 2016 Oct;263(10):2065-79. 218. Toy BC, Aguinaldo T, Eliason J, Egbert J. Non- Striatal Morphometry in Major Depressive Disorder. Mydriatic Fundus Camera Screening for Referral- Neuropsychopharmacology. 2016 Sep;41(10):2481-91. 207. 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233. Wang B, Weiland JD. Analysis of the Peak Resistance 240. Xu SC, Chow J, Liu J, Li L, Maslin JS, Chadha N, 247. Zhang X, Dastiridou A, Francis BA, Tan O, Varma R, Frequency Method. IEEE Trans Biomed Eng. 2016 Chen B, Teng CC. Risk Factors for Visual Impairment Greenfield DS, Schuman JS, Sehi M, Chopra V, Huang Oct;63(10):2086-94. Associated with Corneal Diseases in Southern China. D. Baseline Fourier-Domain Oct Structural Risk Clin Ophthalmol. 2016;10:777-82. Factors for Visual Field Progression in the Advanced 234. Weitz AC, Nanduri D, Behrend MR, Gonzalez-Calle Imaging for Glaucoma Study. Am J Ophthalmol. 2016 A, Greenberg RJ, Humayun MS, Chow RH, Weiland 241. Yang X, Shi L, Daianu M, Tong H, Liu Q, Thompson Dec;172:94-103. JD. Improving the Spatial Resolution of Epiretinal PM. Blockwise Human Brain Network Visual Implants by Increasing Stimulus Pulse Duration. Sci Comparison Using Nodetrix Representation. IEEE 248. Zhang X, Francis BA, Dastiridou A, Chopra V, Tan Transl Med. 2015 Dec 16;7(318):318ra203. Trans Vis Comput Graph. 2016 Aug 5. O, Varma R, Greenfield DS, Schuman JS, Huang D. Longitudinal and Cross-Sectional Analyses of Age 235. Wendelken LA, Jahanshad N, Rosen HJ, Busovaca E, 242. Yang Y, Joshi SH, Jahanshad N, Thompson PM, Effects on Retinal Nerve Fiber Layer and Ganglion Allen I, Coppola G, Adams C, Rankin KP, Milanini B, Baker LA. Neural Correlates of Proactive and Cell Complex Thickness by Fourier-Domain Oct. Clifford K, Wojta K, Nir TM, Gutman BA, Thompson Reactive Aggression in Adolescent Twins. Aggress Transl Vis Sci Technol. 2016 Mar;5(2):1. PM, Valcour V. Apoe Epsilon4 Is Associated with Behav. 2016 Oct 21. Cognition, Brain Integrity and Atrophy in Hiv over Age 249. Zhang X, Loewen N, Tan O, Greenfield DS, Schuman 243. Yu WQ, Eom YS, Shin JA, Nair D, Grzywacz SX, 60. J Acquir Immune Defic Syndr. Epub 2016 May 25. JS, Varma R, Huang D. Predicting Development of Grzywacz NM, Craft CM, Lee EJ. Reshaping Glaucomatous Visual Field Conversion Using Baseline 236. Whelan CD, Hibar DP, van Velzen LS, Zannas AS, the Cone-Mosaic in a Rat Model of Retinitis Fourier-Domain Optical Coherence Tomography. Am Carrillo-Roa T, McMahon K, Prasad G, Kelly S, Pigmentosa: Modulatory Role of Zo-1 Expression in J Ophthalmol. 2016 Mar;163:29-37. Faskowitz J, deZubiracay G, Iglesias JE, van Erp Dl-Alpha-Aminoadipic Acid Reshaping. PLoS One. TG, Frodl T, Martin NG, Wright MJ, Jahanshad N, 2016;11(3):e0151668. 250. Zhu B, Xu J, Li Y, Wang T, Xiong K, Lee C, Yang X, Schmaal L, Samann PG, Thompson PM. Heritability Shiiba M, Takeuchi S, Zhou Q, Shung KK. Micro- 244. Yue L, Weiland JD, Roska B, Humayun MS. and Reliability of Automatically Segmented Human Particle Manipulation by Single Beam Acoustic Retinal Stimulation Strategies to Restore Vision: Hippocampal Formation Subregions. Neuroimage. Tweezers Based on Hydrothermal Pzt Thick Film. AIP Fundamentals and Systems. Prog Retin Eye Res. 2016 2016 Mar;128:125-37. Adv. 2016 Mar;6(3):035102. Jul;53:21-47. 237. Wolle MA, Randleman JB, Woodward MA. 251. Zhu D, Berry JL, Ediriwickrema L, Wong K, Lee 245. Zhang J, Stonnington C, Li Q, Shi J, Bauer RJ, 3rd, Complications of Refractive Surgery: Ectasia after TC, Murphree AL, Kim JW, Jubran R. Long- Gutman BA, Chen K, Reiman EM, Thompson PM, Refractive Surgery. Int Ophthalmol Clin. 2016 Term Outcomes of Group B Eyes in Patients Ye J, Wang Y. Applying Sparse Coding to Surface Spring;56(2):127-39. with Retinoblastoma Treated with Short-Course Multivariate Tensor-Based Morphometry to Predict Chemoreduction: Experience from Children’s 238. Wood EH, Moshfeghi AA, Nudleman ED, Moshfeghi Future Cognitive Decline. Proc IEEE Int Symp Biomed Hospital Los Angeles/University of Southern DM. Evaluation of Visunex Medical’s Panocam(Tm) Lt Imaging. 2016 Apr;2016:646-50. California. Ocul Oncol Pathol. 2015 Dec;2(2):105-11. and Panocam(Tm) Pro Wide-Field Imaging Systems 246. Zhang W, Shi J, Stonnington C, Bauer RJ, 3rd, for the Screening of Rop in Newborn Infants. Expert 252. Zhu J, Qi L, Miao Y, Ma T, Dai C, Qu Y, He Y, Gao Y, Gutman BA, Chen K, Thompson PM, Reiman EM, Rev Med Devices. 2016 Aug;13(8):705-12. Zhou Q, Chen Z. 3d Mapping of Elastic Modulus Caselli RJ, Wang Y. Morphometric Analysis of Using Shear Wave Optical Micro-Elastography. Sci 239. Xu BY, Israelsen P, Pan BX, Wang D, Jiang X, Varma Hippocampus and Lateral Ventricle Reveals Regional Rep. 2016 Oct 20;6:35499. R. Benefit of Measuring Anterior Segment Structures Difference between Cognitively Stable and Declining Using an Increased Number of Optical Coherence Persons. Proc IEEE Int Symp Biomed Imaging. 2016 Tomography Images: The Chinese American Apr;2016:14-8. Eye Study. Invest Ophthalmol Vis Sci. 2016 Nov 1;57(14):6313-9.
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