17th ANNUAL FEBRUARY 21, 2021 NIH GRADUATE STUDENT RESEARCH SYMPOSIUM: FACES OF TOMORROWS SCIENCE 17TH ANNUAL NIH GRADUATE STUDENT RESEARCH SYMPOSIUM FACES OF TOMORROW'S SCIENCE

2021

FOREWORD AND ACKNOWLEDGEMENTS ...... 2

PROGRAM OF EVENTS ...... 4

NIH GRADUATE PARTNERSHIPS PROGRAM GRADUATION AWARD RECIPIENTS ...... 6

OUTSTANDING MENTOR AWARDS ...... 10

STUDENT SPEAKERS ...... 12

STUDENTS ...... 16

POSTERS ...... 20

Graduate Partnerships Program Office of Intramural Training & Education Office of Intramural Research National Institutes of Health U.S. Department of Health & Human Services

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FOREWORD

Every year, the National Institutes of Health (NIH) Graduate Student Research Symposium showcases the breadth of scientific research and the achievements of the graduate student community at the NIH. The symposium is the largest graduate student event of the year - an event in which graduate students can come together to share their research, appreciate the work of their colleagues, and celebrate the successes of the graduate student community.

In its seventeenth year, this annual symposium provides an opportunity to acknowledge the scientific accomplishments of the hundreds of graduate students working on their dissertation research at the NIH. This symposium highlights the spectrum of scientific research conducted by graduate students at the NIH, who represent numerous universities across the world and span nearly all institutes and centers within the NIH. The NIH Graduate Research Symposium recognizes the diversity of research specialties supported by the NIH and exhibits the scientists of tomorrow, from those developing new research proposals to those preparing to defend years of dissertation research.

This symposium will provide the graduate student community with the chance to hear about the scientific work of our peers in several formats. Students will present their research in six virtual sessions across two days through scientific posters judged by NIH postdoctoral fellows and staff scientists. Winners of the poster competition will be awarded the prestigious NIH Graduate Student Research Award, generously funded by the OITE. In addition, eight current students will give oral presentations chosen based on scientific merit and diversity.

Our 5th annual elevator pitch competition, in which current graduate students will be judged on their ability to explain their science to a general audience in two minutes or less, will follow a slightly different format this year, with students submitting videos in advance. The final event will be held live on the morning of Feb. 18th. Following a second exciting day of posters and talks, a graduation ceremony will be held to recognize those students who have defended their dissertations within the past year. Dr. Michael Gottesman and Dr. Sharon Milgram will present the recent graduates with a certificate in honor of their accomplishments. Afterwards, we will conclude the day with the presentation of awards for outstanding research mentors. Our success as graduate students would not be the same without the guidance of high-quality research mentors who have supported us in innumerable ways, from providing networking opportunities to career development advice. We are grateful for the influential mentorship provided at the NIH to help us become independent scientists and forge relationships extending beyond graduate school. Four outstanding mentors nominated by their students will be honored for their leadership, support, and dedication to their graduate students.

We are thankful for the opportunity to share our research with the entire NIH community at the 17th Annual NIH Graduate Student Research Symposium. We thank all of the graduate students who have participated in this event and those who have provided us with continuous support in our scientific careers. We hope this event establishes new connections and collaborations and inspires future scientific contributions to the community at the NIH.

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ACKNOWLEDGEMENTS We are grateful to the Training and Scientific Directors of the NIH Institutes and Centers, the Graduate Partnerships Program (GPP) Directors, and the Graduate Student Council (GSC) for their continuous support of the graduate student community and for the opportunity to recognize the achievements of the NIH graduate students at this symposium. We would like to thank Dr. Gail Seabold and Dr. Phil Ryan for organizing the symposium poster session, and we acknowledge the effort of the postdoctoral fellow and staff scientist judges for helping to make the poster competition possible. We would like to thank GSC representatives Kat Daly and Julia Gross for managing the Outstanding Mentor Awards and the 2020 GSC co-chairs, Katelyn McCann and Kat Daly, for all of their efforts and dedication to the GSC and graduate student community. This symposium would not be possible without the help of the Office of Intramural Training and Education (OITE). We are especially thankful for Dr. Sharon Milgram, Dr. Philip Wang, Dr. Phil Ryan, Dr. Laura Marler, and other OITE staff who have contributed significantly to the planning of this event. We are grateful to Dr. Michael Gottesman for his time to honor our recent graduates, and the NIH leadership for their continued support of the graduate community. Finally, we would like to thank the graduate students, mentors, alumni, and all attendees whose participation made this event successful.

THE 17TH ANNUAL NIH GRADUATE RESEARCH SYMPOSIUM COMMITTEE Yasemin Cole, NCI, University of Cambridge Kat Daly, NIMH, Johns Hopkins University Franklin Ning, NCI, University of Maryland, Baltimore Neha Wali, NCI, University of Oxford

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NIH GRADUATE STUDENT RESEARCH SYMPOSIUM • “THE FACES OF TOMORROW’S SCIENCE”

FEBRUARY 17, 2021 PROGRAM OF EVENTS

10:00 am-11:00 am POSTER SESSION I Posters 6-25

11:15 am-12:15 pm POSTER SESSION II Posters 3 - 5, 26 - 34, 39 - 48, 54 - 58

1:00 pm-2:00 pm POSTER SESSION III Posters 37 - 38, 49 - 53, 59 - 77

2:15 pm-4:00 pm STUDENT PRESENTATIONS Amelia Foss, University of Cambridge, NCI Patient-derived Glioblastoma Cells Exhibit Distinct Rheological Profiles Associated with Altered Cytoskeleton Regulatory Pathway Activity

Justin Gray, Johns Hopkins University, NCI Apoptosis Induced Nuclear Bursting in Tumor Cells Drives S100A4 Mediated Metastatic Outgrowth

Shachar Abudi, Tel Aviv University, NHGRI Systemic Administration of AAV5/AAV8-Hps1 to Prevent Hermansky-Pudlak Syndrome-associated Pulmonary Fibrosis in Mice

Juan Enríquez Traba, Universidad Autonoma de Madrid, NIMH Nucleus Accumbens Dopamine D3 Receptor Regulates Information Processing and Motivated Behavior

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NIH GRADUATE STUDENT RESEARCH SYMPOSIUM • “THE FACES OF TOMORROW’S SCIENCE”

FEBRUARY 18, 2021 PROGRAM OF EVENTS

10:00 am - 10:30 am ELEVATOR PITCH COMPETITION FINAL

10:45 am - 11:45 am POSTER SESSION IV Posters 1, 79 - 103

1:00 pm - 2:00 pm POSTER SESSION V Posters 104 - 129

2:00 pm - 3:45 pm STUDENT PRESENTATIONS Russell Quinn, Johns Hopkins University, NEI Characterization of Immune Behavior in Health and Development of 3-D Bioprinted RPE/Choroid

Melissa Arroyo-Mendoza, Iowa State University, NIDDK Characterization of a Unique σ70 Variant of an Adherent Invasive Escherichia coli, LF82, a Pathobiont Associated with Crohn’s Disease

Andrew Lauziere, University of Maryland, College Park, NIBIB An Exact Hyper Graph Matching Algorithm for Nuclear Identification in Embryonic Caenorhabditis elegans

Keyla Tumas, Georgetown University, NIAID Plasmodium yoelii 17XNL Infection Induces Macrophage Dysfunction and Blockage of Erythrocyte Maturation

4:00 pm - 5:00 pm GRADUATION CEREMONY Certificates presented by: Michael M. Gottesman, MD, NIH Deputy Director for Intramural Research Sharon L. Milgram, PhD, Director, NIH Office of Intramural Training and Education

Outstanding Mentor Awards

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GPP GRADUATION AWARD RECIPIENTS

GPP GRADUATION AWARD RECIPIENT, NIH IC, UNIVERSITY, DISSERTATION TITLE MENTOR UNIVERSITY MENTOR

Aisha Ahmed AlJanahi NHLBI Georgetown University Prediction and Validation of Hematopoietic Stem and Progenitor Dr. Cynthia Dunbar Cell Off-Target Editing in Transplanted Rhesus Macaques

Majed Naser Almashjary NIAID Catholic University of The Impact of Dietary Iron Restriction on Sickling Kinetics and Dr. Hans Ackerman America Hemolysis in a Transgenic Mouse Model of Sickle Cell Disease Dr. Wadad AlSalmi

Elisa Arthofer NIDCR Karolinska Institutet A Frizzled quest to dissect the molecular pharmacology of WNT Dr. J. Silvio Gutkind Dr. Gunnar Schulte signaling: from biology to signaling mechanism(s) Dr. Tamas Balla

Lingyu Bao NIDCD Xi'an Jiaotong University Thyroid Hormone Receptor Alpha Mutations and PRMT1 Dr. Yun-Bo Shi Dr. Binying Shi Knockout Lead to Epithelial Defects in the Adult Intestine in the Mouse Model of Resistance to Thyroid Hormone

Jeanee L. Bullock NEI Georgetown University The Role of Pigment Epithelium-Derived Factor and Its Receptor Dr. S. Patricia Becerra in Retinal Cells

Brian Caffrey NCI University of British Three-Dimensional Transmission and Scanning Electron Dr. Sriram Subramaniam Columbia Microscopy of Molecular and Cellular Structures

Sarah Isabel Davies NHLBI Georgetown University Virus-Positive Merkel Cell Carcinoma Specific T Cells Are Dr. Isaac Brownell Robustly Generated from Healthy Donor Blood Dr. John Barrett

Justin Tate Demmerle NICHD University of Oxford Integrating Chromatin and Development: LDB1 Regulates Dr. Todd Macfarlan Dr. Lothar Schermelleh Genome Architecture and Gene Expression in Motor Neuron Differentiation

Mitchell W. Dorrell NICHD University of Delaware Simulation-Derived Neutron Scattering for Lipid Membranes Dr. Alexander Sodt Dr. Edward Lyman

Kara Fulton NINDS Brown University Wiring Specificity of Molecularly Distinct Interneurons in the Dr. Kevin Briggman Mouse Olfactory Bulb

David Alejandro Garcia Grisales NCI University of Maryland, Transcription Factor Confinement and Chromatin Dr. Gordon L. Hager College Park Binding and its Role in Transcriptional Regulation Dr. Arpita Upadhyaya

Anjelika Gasilina NCI Georgetown University The Mechanism of Actin Remodeling by the N-BAR Domain of Dr. Paul A Randazzo ASAP1

Meghali Goswami NHLBI George Washington T cell Immunity in Acute Myeloid Leukemia Patients After Dr. Christopher Hourigan University Chemotherapy and During Immune Checkpoint Inhibition Dr. Norman H. Lee

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GPP GRADUATION AWARD RECIPIENTS

GPP GRADUATION AWARD RECIPIENT, NIH IC, UNIVERSITY, DISSERTATION TITLE MENTOR UNIVERSITY MENTOR

Phillip S. Hudson NHLBI University of South Florida Breakthroughs in Obtaining QM/MM Free Energies Dr. Bernard Brooks Dr. H. Lee Woodcock

Kevin James Hughes NCI Yale University Regulation of an RNA repair operon in Salmonella enterica Dr. Sandra Wolin serovar Typhimurium

Shiyun Jin NIAAA Anhui Medical University Spinal Astrocytic ALDH2 Mediates Alcohol Metabolism And Dr. David Lovinger Alcohol Analgesia Dr. Li Zhang

Jing Liang-Guallpa NIDDK Brown University Interrogation of Neurobiological Responses to Diet Choice Dr. Michael Krashes

Jing Ma NIAAA Southern Medical Chronic-plus-binge alcohol intake induces production of Dr. Bin Gao University proinflammatory mtDNA-enriched extracellular vesicles and hepatitis via ASK1 and p38MAPKα-dependent mechanisms

Jennifer Casiano Matos NIAID Rutgers University Parsing Polyprotein Processing, Host Protein Interaction, and Dr. Joseph Marcotrigiano Immune Evasion of Positive Sense RNA Viruses

M. Jeremiah Matson NIAID Marshall University A Retrospective Analysis of Ebola Virus Disease in Liberia Dr. Vincent J. Munster Dr. Daniel S. Chertow

David Ortolan NEI University of L'Aquila In-vitro Generation of iPSC-derived Macular and Peripheral Dr. Kapil Bharti Retinal Pigment Epithelial Cells Using a Machine Learning- Based High Content Screen

Jacob Joseph Paiano NCI University of Pennsylvania Genome Integrity and Cell Division: Next-Generation Answers to Dr. Andre Nussenzweig Enduring Questions

Jiajia Pan NCI East China Normal Construction and therapeutic analysis of recombinant Dr. Mitchell Ho University immunotoxins for treating pancreatic cancer

Kyemyung Park NIAID University of Maryland, Scalable Modeling Approaches in Systems Immunology Dr. John S. Tsang College Park Dr. Doron Levy

Simona S. Patange NCI University of Maryland, Thyroid Hormone Receptor Alpha Mutations and PRMT1 Dr. Daniel R. Larson College Park Knockout Lead to Epithelial Defects in the Adult Intestine in the Dr. David Levens Dr. Michelle Girvan Mouse Model of Resistance to Thyroid Hormone

Emily Phung NIAID George Washington Conformation Matters: Immunity Elicited by the Stabilized Pre- Dr. Barney Graham University Fusion F Subunit Vaccine DS-Cav1 is Potent and Durable

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GPP GRADUATION AWARD RECIPIENTS

GPP GRADUATION AWARD RECIPIENT, NIH IC, UNIVERSITY, DISSERTATION TITLE MENTOR UNIVERSITY MENTOR

Samuel Porter NIAID University of Maryland, Chromatin Control of Papillomavirus Infection Dr. Alison McBride College Park

Naemeh Pourshafie NINDS George Washington Linking Transcriptional Dysregulation to Mitochondrial Dr. Kenneth Fischbeck University Dysfunction in Spinal and Bulbar Muscular Atrophy

Husam Qanash NHLBI Catholic University of Eltrombopag Improves Erythroid Differentiation in a Human Dr. Andre Larochelle America Induced Pluripotent Stem Cell Model of Diamond Blackfan Anemia

Joseph C. Roney NINDS University of Oxford Axonal Transport of Lysosomes and Its Relevance to Axonal Dr. Zu-Hang Sheng Dr. Francis Platt Homeostasis in Niemann-Pick Disease Type C

Heather L. Rusch NIMH Karolinska Institutet Links Between Stress, Sleep, and Inflammation: Dr. Jessica Gill Dr. Julie Lasselin A Translational Perspective of Resilience Dr. Christian Grillon Dr. Mats Lekander

Dilorom Sass NINR University of Nebraska The Role of Extracellular Vesicles in Cancer-Related Fatigue and Dr. Leorey Saligan Medical Center its Co-Occurring Symptoms Dr. Leonid Margolis Dr. Paula Schulz

Keith T. Schmidt NCI Utrecht University Novel Therapeutic Approaches to Overcome Acquired Dr. William Douglas Figg Dr. Alwin D. R. Huitema Resistance to Enzalutamide in Patients with Advanced Prostate Cancer

Albert Chi Sek NIAID University of California, Eosinophil Infiltration in Muscular Dystrophy: Key Dr. Helene Rosenberg Los Angeles Characteristics and Contributions to Disease Dr. Tomas Ganz

Ahmad Abdullah Shaikh NHLBI Catholic University Understanding the Mechanisms of Graft Rejection and Tolerance Dr. Courtney Fitzhugh of America, Induction After Nonmyeloablative Haploidentical Hematopoietic Dr. Justin Chung Stem Cell Transplantation for Sickle Cell Disease

Ivan Adolfo Rey Suarez NIBIB University of Maryland, Receptor Mobility and Cytoskeletal Dynamics at the Immune Dr. Hari Shroff College Park Synapse: The Role of Actin Regulatory Proteins Dr. Arpita Upadhyaya

Samantha G. Tilson NIDDK University of Cambridge Induced Pluripotent Stem Cell Derived Liver Model for the Study Dr. T. Jake Liang Dr. Ludovic Vallier of PNPLA3-Associated Non-Alcoholic Fatty Liver Disease

Michael Joseph Tisza NCI Johns Hopkins University Rendering the Unseen Virome Visible Dr. Christopher Buck

Calandra G. Whitted NHGRI Florida Agricultural and Exploring the Use Family Health History in Black Communities Dr. Laura Koehly Mechanical University in the Deep South Dr. Torhonda Lee

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GPP GRADUATION AWARD RECIPIENTS

GPP GRADUATION AWARD RECIPIENT, NIH IC, UNIVERSITY, DISSERTATION TITLE MENTOR UNIVERSITY MENTOR

Audrey Marie Winkelsas NINDS University of Oxford Targeting the 5’ Untranslated Region of SMN2 as a Therapeutic Dr. Kenneth Fischbeck Dr. Matthew Wood Strategy for Spinal Muscular Atrophy

Hiu tung Candy Wong NIDCD Johns Hopkins University Synaptic Mitochondria Regulate Hair-Cell Synapse Size Dr. Katie Kindt and Function

Zinan Zhang NIAID University of Cambridge From Phenotype to Genotype: Discovery of New Primary Dr. Michael Lenardo and Harvard Medical Immunodeficiencies School Dr. Ken Smith

Wei Zhao NIAID Sichuan University The Function of AKT in NLRP3-related Dr. John Kehrl Dr. Min Wang Inflammasome Activation

Wenjie Zhu NEI Sun Yet-sen University The Efficacy and Mechanism Study of Baicalin in Alleviating Dr. Rachel Caspi Autoimmune Uveitis

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OUTSTANDING MENTOR AWARD RECIPIENTS

Dr. Cynthia Dunbar has pursued a career encompassing clinical investigation, basic science, and education. She graduated from Harvard University with an undergraduate degree in the History of Science followed by a medical degree from Harvard Medical School. Following internal medicine residency training at the Boston City Hospital, she came to the NIH as a postdoctoral research fellow, training in the laboratory of Dr. Arthur Nienhuis. Following completion of clinical hematology training at University of California, San Francisco, she returned to the NHLBI intramural program as a Principal Investigator in 1991. As a translational research scientist, she investigates hematopoiesis, stem cell biology, leukemogenesis, natural killer cell biology, and gene therapies targeting hematopoietic stem cells, utilizing non-human primate models predictive of human biology. She has carried out landmark clinical trials in gene therapies, transplantation, autoimmune disease, and bone marrow failure, including recent studies leading to the regulatory approval of the thrombopoietin mimetic eltrombopag as a new treatment for bone marrow failure. She was elected to the National Academy of Medicine in 2020. She is active in the leadership of major professional societies, including service as the past President of the American Society for Cell and Gene Therapy and as the current Secretary of the American Society of Hematology. She served as Editor-in-Chief of the hematology journal BLOOD from 2007-2013, the first woman to serve in this position. She has led the NIH Assembly of Scientists and made efforts throughout her career to foster gender and ethnic diversity in science and medicine and to support the career development of physician-scientists.

Dr. Marc Ferrer is currently the Director of the 3D Tissue Bioprinting Laboratory at NCATS. He graduated with a BSc degree in Organic Chemistry from the University of Barcelona, Spain, in 1989, and received his PhD degree in Biological Chemistry from the University of Minnesota, in 1994. He was a postdoctoral fellow at Harvard University from 1995-1999, where he used structure-based chemical approaches for the development of anti-HIV small molecules. He joined the Department of Automated Biotechnology at the Merck Research Laboratories in 1999, where he became Director of Assay Development and High Throughput Screening. In 2010, he joined the NIH Chemical Genomics Center working on the discovery of small molecule probes to study protein function. In the last four years, he has led the implementation of the 3D Tissue Bioprinting Laboratory, a multidisciplinary group with the goal of creating and using 3D bioengineered tissues for disease modeling and drug discovery and development. Dr. Ferrer has co-authored more than 120 peer-reviewed scientific publications.

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OUTSTANDING MENTOR AWARD RECIPIENTS

Dr. William Grimes received his BA from Monmouth College in 2003, and his PhD from the University of Maryland in 2008, where he studied synaptic transmission and dendritic integration in the mammalian retina with Jeffrey Diamond. During his postdoctoral training with Dr. Fred Rieke at the University of Washington, Dr. Grimes studied the neural basis of retinal computation and human perception under intermediate lighting conditions. Dr. Grimes joined NINDS as a Staff Scientist in 2017 and is currently focused on the functional roles of retinal interneurons in healthy and diseased mammals.

Dr. Mariana Kaplan is Senior Investigator and Chief of the Systemic Autoimmunity Branch at NIAMS, and Deputy Scientific Director of this institute. Dr. Kaplan did her medical training and Internal Medicine Residency in Mexico City and completed her rheumatology fellowship and postdoctoral training at the University of Michigan, where she spent many years as faculty. Her research has focused on identifying mechanisms of immune dysregulation, organ damage, and premature vascular disease in systemic autoimmune diseases such as lupus and rheumatoid arthritis. Recently, her research has focused on identifying neutrophil dysregulation and the role of neutrophil extracellular traps in systemic autoimmune disorders. Dr. Kaplan also has an interest in identifying novel therapeutic targets that may prevent premature vascular damage in systemic autoimmunity and has led clinical trials to identify mechanisms that reduce blood vessel dysfunction and mitigate organ damage in chronic inflammatory disorders. She is also an active clinician at the NIH. Among various awards, she was inducted into the American Society for Clinical Investigation and the Association of American Physicians, received the Henry Kunkel Young Investigator Award from the American College of Rheumatology, and the Evelyn Hess Award from the Lupus Foundation of America in recognition of her significant contributions to lupus research, diagnosis, and treatment.

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STUDENT SPEAKERS

Shachar Abudi is a 4th year MD-PhD candidate in the Tel Aviv University-NIH GPP. She is co-advised by Dr. Yair Anikster (Tel Aviv University), Dr. May Malicdan (NIH-UDP), and Dr. William Gahl (NHGRI). In 2014, after two years of service in the Israeli army, Shachar started her biomedical career and enrolled to obtain a medical degree. Pursuing her passion for translational medicine, Shachar successfully applied to the GPP program in 2017 and initiated her PhD studies in the lab of Prof. Anikster, head of the Metabolic Disease Unit at Edmond and Lily Safra Children's Hospital, Sheba Medical Center in Israel. There, Shachar was involved in elucidating the molecular bases of inborn errors of metabolism and rare genetic disorders. She collaborated in the identification of several new disorders, including PPCS-associated dilated cardiomyopathy. As a part of the GPP, she joined the lab of Dr. William Gahl at the NHGRI in 2018, where her studies are focused on a rare genetic disease called Hermansky Pudlak syndrome type 1. HPS1 patients manifest albinism, excessive bleeding and pulmonary fibrosis (HPSPF), an irreversible and lethal restrictive lung disease. There is no available treatment for HPSPF. To study the disease mechanism and therapeutic aspects of HPSPF, Shachar established animal models that mimic the human phenotype, and she is using them to study different approaches for gene therapy. The first approach is gene complementation that gives an additional, normal copy of the mutated gene; the second is gene editing that fixes the mutation in the DNA. Dr. Gahl’s lab is hoping that one day they will be able to treat HPS patients with gene therapy. Currently, Shachar holds a bachelor degree in Medical Sciences (B.Med.Sc) and a Master of Science degree; soon, she will earn her MD and PhD degrees. Shachar is grateful for the opportunity to share her research with the NIH graduate student community.

Melissa Arroyo-Mendoza is starting her 3rd year as a PhD student in the individual Graduate Partnership Program between Iowa State University (ISU) and NIH-National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). Melissa received her BS and MS from California State Polytechnic University, Pomona in Biology. As an undergraduate and then MS student, Melissa was under the mentorship of Dr. Nancy Buckley, investigating whether cannabinoids such as delta-9-tetrahydrocannabinol (THC) and the peripheral cannabinoid receptor (CB2R) affect mouse resistance to systemic yeast infections. Her thesis focused on the differences in the immune response and susceptibility to systemic Candida albicans (C. albicans) infection between female and male mice and whether sex hormones are responsible for the sex-dependent susceptibility to this infection. Her research demonstrated that male mice were more susceptible, and it strongly suggested that testosterone plays an important role in decreasing resistance to a systemic C. albicans infection. Upon completing her MS, Melissa joined the lab of Dr. Deborah Hinton at NIDDK as a post-masters fellow where she investigated the role of previously uncharacterized phage proteins that aid in bacterial host takeover. As a PhD student, she is conducting her dissertation research under the mentorship of Dr. Hinton (NIDDK) and Dr. Gregory Phillips at ISU, characterizing a unique variant present in RNA polymerase of LF82, an Adherent Invasive Escherichia coli that is associated with Crohn’s Disease. Her work has shown that this single mutation in the transcriptional machinery leads to significant global transcriptional changes. Melissa is very grateful for this opportunity to share her work 12 and would like to thank OITE and NIH for their continued support. GRADUATE STUDENT RESEARCH SYMPOSIUM 2021

STUDENT SPEAKERS

Juan Enriquez Traba is a second-year PhD student in an individual graduate partnership between the Cajal Institute of Madrid, Spain and the National Institute of Mental Health (NIMH). Juan graduated from the Autonomous University of Madrid in 2017, earning a BS in Biochemistry and Molecular Biology. His undergraduate thesis work in Dr. Rosario Moratalla’s laboratory, involving the study of dopamine D1 and glutamate mGluR5 receptors in regulating Parkinson’s disease and L-DOPA- induced dyskinesias, allowed Juan to become proficient in systems neuroscience techniques. After completing his BS, Juan received a Master’s in Biotechnology at the University of Edinburgh in Scotland, where he trained in computational neuroscience. For his MSc dissertation, Juan developed a computational model to simulate the neurobiological processes of spatial learning and navigation in the Morris Water Maze task and presented this work at the 11th FENS Forum of Neuroscience (Berlin, 2018). Juan then began a collaborative PhD program under the mentorship of Dr. Moratalla and Dr. Hugo Tejeda at NIMH. He joined the Unit on Neuromodulation and Synaptic integration led by Dr. Tejeda in 2019, where he is currently elucidating the role of the nucleus accumbens dopamine receptors in regulating motivated behavior by employing electrophysiological, viral/transgenic and optogenetic approaches. This could eventually aid in the understanding of the underlying causes of neuropsychiatric disorders, the most prevalent cause of disability in the US population.

Amelia Foss is a second-year PhD candidate in Oncology with the NIH-OxCam Program. She is co-advised by Dr. Kandice Tanner and Dr. Michael Gottesman (NCI) and Dr. Manav Pathania (University of Cambridge). Amelia’s research combines cell biology, in vivo work, and biophysics techniques to investigate the role of biomechanics in the progression of glioblastoma (GBM). In her work at the NCI, she investigates mechanical properties of patient-derived GBM cells, as well as their molecular and mechanical interaction with the local microenvironment in vivo in zebrafish models. Amelia received her bachelor’s degree in Molecular Biology from Princeton University, where she first experienced a fascination with biological research studying drosophila development in the lab of Dr. Elizabeth Gavis. Following graduation, she was awarded a Fulbright fellowship to research kidney disease at Semmelweis Medical University in Hungary. She pursued her master’s degree through the Erasmus Mundus Joint Master Degree program, studying translational research at Heidelberg University in Germany and at Uppsala University in Sweden. At Heidelberg University, with Dr. Jonathan Sleeman, she investigated the role of senescence in metastatic melanoma, establishing her interest in cancer research. At Uppsala University, in the lab of Dr. Anna Dimberg, Amelia began her study of glioblastoma, probing the interaction between GBM tumors and tumor-associated vasculature. Amelia is grateful to the NIH-OxCam program for the opportunity to employ a unique interdisciplinary approach in her continuing study of glioblastoma, and is grateful to the many mentors and colleagues that have supported her thus far.

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STUDENT SPEAKERS

Justin Gray is a fourth-year PhD candidate in the Johns Hopkins-NIH GPP. Justin graduated from the University of Central Florida where he earned a B.S. in Biomedical Sciences with Honors. In his undergraduate, he received an NSF fellowship focused on STEAM education that funded his cancer research and allowed him to teach art, music, and graphic design classes about cancer research. The ensuing art, based on a myriad of subjects related to cancer, including personal stories, his own research, and the impact that science has on others has been a consistent motivator for Justin. At the start of his dissertation research under Dr. Li Yang, Justin focused on understanding how the immune microenvironment impacts tumor cell dormancy. In the last two years, Justin has studied how tumors can use cell death to their advantage. Using time-lapse microscopy and image analysis he discovered and characterized a novel cell death phenotype that benefits nearby tumor cells leading to the formation of large macrometastases. Justin is grateful for his colleagues at the NIH and Johns Hopkins that have made his work possible.

Andrew Lauziere is a fifth-year PhD candidate in Applied Mathematics at the University of Maryland, College Park and in his third year with the UMD-NCI GPP. Andrew graduated from UMD in 2016 studying mathematics and economics. He then elected to continue his studies in applied mathematics at UMD and joined the Applied Mathematics, Statistics & Scientific Computation (AMSC) program. During his tenure teaching undergraduate statistics, Andrew led initiatives on campus to enhance and support STEM education for US veterans. He then joined the UMD-NCI GPP to do research with Dr. Hari Shroff at NIBIB while being co-advised by Dr. Radu Balan (UMD). Andrew concurrently joined COMBINE: Computation and Mathematics for Biological Networks, an NSF funded research traineeship program at UMD. While at NIH, Andrew has collaborated with FAES as faculty to design and teach statistics courses with the goal of preparing trainees to properly apply statistical methods in biological research. Andrew’s research has concerned the curation of statistically guided discrete optimization algorithms to assist in nuclear tracking in fluorescence microscopy. His philosophy is to leverage data driven computational methods in order to improve the efficiency in performing biomedical research. His foremost goal as a researcher is to bridge members of mathematical and biological communities to foster communication, education, and collaboration. Andrew is particularly grateful to faculty and staff across NIBIB and the Department of Mathematics at UMD for guiding and supporting his growth as a researcher and a leader.

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STUDENT SPEAKERS

Russell Quinn is a 4th year PhD Candidate in the Johns Hopkins-NIH GPP, presently pursuing his thesis in the laboratory of Dr. Kapil Bharti. Russ received his BS degree in Biochemistry from Virginia Tech in 2013, while also interning with physicians at the University of Maryland Medical School during the off seasons. These summers were spent investigating the role of survivin, a known oncogene, and its’ associated role in esophageal tumor growth and severity. After graduation, Russ would first join the NIH as a part of Dr. Dan Sackett’s group within the NICHD, where he began work on evaluating tubulin content and stability in the parasite genus Leishmania. Anti-parasitic drugs - which were believed to target parasite specific tubulin domains - were able to be evaluated for their efficacy, leading to improved screening accuracy for a neglected tropical disease. Russ has since joined the National Eye Institute’s Bharti Lab, where he has helped develop IPSC derived bio-engineered tissues used to model ocular pathologies in a physiologically relevant 3D in vitro system. His thesis work has sought to incorporate monocytes and macrophages within these engineered constructs, in order to investigate the role these innate immune cells play in the development of the back of the eye. Additionally, he has been able to examine how changes in the ratio of these immune cells can influence and exacerbate pathological conditions such as Age Related Macular Degeneration (AMD). He would like to thank the NIH, and OITE in particular, for giving him an opportunity to share his work with our research community, as well as for the extraordinary mentorship he has received from its members.

Keyla Tumas is a sixth year PhD candidate in the Georgetown University-NIH GPP. Keyla graduated from Ithaca College in 2013 with a Bachelor of Science in Biology. Her undergraduate honors research characterized the glue secreted from slugs to help mimic its properties for possible biomedical applications. Following graduation, she completed a summer research project at Gilead Sciences on liver fibrosis. She then worked as a postbaccalaureate researcher at Los Alamos National Laboratory on various projects for the Biosciences Division. For her PhD dissertation, Keyla is performing research at the National Institute of Allergy and Infectious Diseases in Dr. Xin-zhuan Su’s laboratory, which concentrates on dissecting the host-pathogen interactions utilizing rodent malaria parasite models. In particular, Keyla has focused on characterizing malaria induced anemia phenotypes and identifying possible molecular mechanisms for the changes to the red blood cell production. Overall, she is immensely grateful for all of her time spent with the NIH graduate student community and wishes all the best to the other graduate students!

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STUDENTS Listed alphabetically by name

Poster # Last Name, First IC University 28 Abudi, Shachar NHGRI Tel Aviv University

48 Alcantara, Ivan NIDDK Brown University

3 Ali, Muhammad Basil NHGRI National Institute for Biotechnical and Genetic Engineering

104 Alkalasi, Mor NICHD Brown University

110 Almansour, Faisal NCI Georgetown University

9 Andargie Temesgen NHLBI Howard University

27 Arroyo-Mendoza, Melissa NIDDK Iowa State University

70 Avanzaro, Victoria NIAID University of Oxford

64 Bellotti, Adriano NICHD University of Cambridge

83 Bernstein, Aaron NCI University of Cambridge

94 Boehm, Matthew NIDA Brown University

77 Cai, Teddy NICHD University of Oxford

84 Capoferri, Adam NCI Georgetown University

19 Castejon Mariscal de Gante, Maria NIA IMDEA Food - Universidad Autonoma de Madrid 49 Chapman, Joseph NHLBI Johns Hopkins University

32 Chidster, Stephanie NINR University of Missouri, St. Louis

16 Cole, Yasemin NCI University of Cambridge

4 Collins, Joshua NIDCR Johns Hopkins University

60 Coomer, Charles NCI University of Oxford

89 Corcoran, Sean NCI University of Cambridge

24 Dada, Hannah NIAMS University of Oxford

129 Daly, Kat NIMH Johns Hopkins University

22 Delgado, Jose CC University of Maryland, College Park

74 Diederichs, Kathryn NIDDK Johns Hopkins University

98 Donahue, Kaitlynn NCI Georgetown University

11 Enriquez Traba, Juan NIMH Universidad Autonoma de Madrid

59 Fenimore, John NCI University of Maryland, Baltimore County

46 Fingleton, Erin NINDS Brown University

91 Foss, Amelia NCI University of Cambridge

30 Freeman, Joshua NICHD University of Massechusetts, Amherst

88 Fu, Yaojie NIAAA Central South University

38 Fulfulan, Amro NHLBI Catholic University of America

82 Giles, Abigail NHLBI University of Cambridge

13 Glotfelty, Elliot NIA Karolinska Institutet

44 Goldbach, Hannah NIMH Brown University

16 GRADUATE STUDENT RESEARCH SYMPOSIUM 2021

STUDENTS Listed alphabetically by name

Poster # Last Name, First IC University 96 Goldbach, Hannah NIMH Brown University

109 Gordon, Jacob NIEHS University of Cambridge

2 Gorrell, Laura NICHD Rensselaer Polytechnic Institute

17 Graf, Akua NIDDK University of Illinois, Chicago

29 Gray, Justin NCI Johns Hopkins University

34 Griffin, Keith NCI Georgia Institute of Technology

101 Gross, Julia NIAID Emory University

112 Gu, Tansy NIEHS University of North Carolina, Chapel Hill

25 Han, Jiajia NIDCR Peking Union Medical College

10 Hogan, Chad NCI Stony Brook University

76 Huffer, Katherine NINDS Johns Hopkins University

43 Huntsicker, Kathleen NIMH Brown University

57 Hurson, Amber NCI University of North Carolina, Chapel Hill

58 Irvin, Sarah NCI University of Maryland, College Park

117 Jankowski, Jakub NIDDK University of Veterinary Medicine, Vienna

107 Jin, Shiyun NIAAA Anhui Medical University

35 Johansen, Kristoffer NIAID University of Cambridge

71 Jung, Olive NCATS University of Oxford

56 Kacar, Zeynep NCI University of Maryland, College Park

106 Keary, Kevin NIMH Brown University

66 Kin, Brian NICHD Brown University

69 Kim, JungHyun NIAID University of Maryland, College Park

51 Kluss, Jillian NIA University of Reading

21 Kolluri, Aarti NCI Mayo Clinic Graduate School of Biomedical Sciences

53 Konstantinidou, Parthena NIDDK University of Patras

122 Krishnan, Anagha NCI University of Cambridge

47 Kumar, Samika NIMH University of Cambridge

97 LaFosse, Paul NIMH University of Maryland, College Park

92 Lagal, Daniel NIAID Universidad de Córdoba

36 Lam, Khiem NCI University of Maryland, College Park

67 Lauziere, Andrew NIBIB University of Maryland, College Park

54 Lee, Olivia NCI University of Texas, MD Anderson Cancer Center

115 Lee Benjamin NLM University of Oxford

42 Levenstein, Jacob NIMH University of Oxford

118 Levitis, Elizabeth NIMH University College London

93 Li, Xiaoyi NINDS Johns Hopkins University

17 NATIONAL INSTITUTES OF HEALTH

STUDENTS Listed alphabetically by name

Poster # Last Name, First IC University 8 Liang, Jonathan NIAID University of Cambridge

113 Liao, Tsung-Jen NCI University of Maryland, College Park

14 Licholai, Julia NIDCR Brown University

80 Liu, James NEI Johns Hopkins University

78 Lukasz, Daria NIDCD Johns Hopkins University

23 Lundgren, Daniel NHLBI University of Cambridge

40 Maldonado. Ana NIMHD University of Maryland, Baltimore County

72 Masih, Katherine NCI Johns Hopkins University

85 Meadows, Allison NHLBI University of Cambridge

100 Mirazee, Justin NCI Johns Hopkins University

127 Mortazavi, Armin NINDS Georgetown University School of Medicine

86 Mule, Matthew NIAID University of Cambridge

18 Murray, Béga NCI Queen's University Belfast

114 Nazari, Shayan NIDCR University of North Carolina, Charlotte

103 Ng, Caleb NEI University of Pennsylvania

20 Ning, Franklin NCI University of Maryland, Baltimore

128 Nisbett, Khalin NIDA University of Illinois, Chicago

81 Pade, Leena NCI University of Maryland, College Park

126 Pasternack, Nicholas NINDS University of Cambridge

1 Phelan, Michael NEI Temple University

105 Piccus, Zoe NICHD Brown University 37 Potter, ELizabeth VRC Johns Hopkins University

26 Quinn, Russell NEI Johns Hopkins University

90 Rao, Nina NCI Johns Hopkins University

95 Rivera, Luis NCCIH Universidad Central Del Caribe

55 Robinson, Welles NCI University of Maryland, College Park

124 Romo-Tena, Jorge NIAMS Universidad Nacional Autonoma de Mexico

31 Rosoff, Daniel NIAAA University of Oxford

123 Ruiz, Stormy NIA Johns Hopkins University School of Medicine

116 Sabir, Marya NINDS University of Oxford

125 Seddighi, Sahba NINDS University of Oxford

79 Shammas, Mario NINDS University of Cambridge

7 Shannon, John NIAID University of Cambridge

39 Silverstein, Shana NIAA University College London

68 Sincox, Brittany NINDS University College London

108 Sitza, Giacomo NIAAA Karolinska Institutet

18 GRADUATE STUDENT RESEARCH SYMPOSIUM 2021

STUDENTS Listed alphabetically by name

Poster # Last Name, First IC University 63 Smith, Kyle NCI Stony Brook University

119 Spatola, Gabriella NHGRI University of South Carolina

121 Steffke, Emily NCI University of Oxford

5 Sucich, Dylan NIAAA Johns Hopkins University

75 Taumoefolau, Grace NIAAA Johns Hopkins University

65 Tong, Ai Phoung NINDS University of Oxford

61 Tumas, Keyla NIAID Georgetown University

52 Vega Sendino, Maria NCI Universidad Autónoma de Madrid

62 Vimonpatarnon, Sinmanus NIAID Mahidol University

111 Wade, Heidi NCI University of Maryland, College Park

50 Wagh, Kaustubh NCI University of Maryland, College Park

120 Wali, Neha NCI University of Oxford

87 Wedekind, Lauren NIDDK University of Oxford

99 Williams, Adeline NIAID Colorado State University

102 Williams, Stephanie NIAID University of Oxford

41 Wlaschin, Josette NICHD Johns Hopkins University

15 Wodrich, Andrew NINDS Georgetown University

12 Wright, Andrew NIDA Brown University

33 Yu, Yulan NHLBI University of Maryland, College Park

6 Zhang, Mengyang NHLBI George Washington University

45 Zhang, Jiali NINDS University of Oxford

73 Yifan, Zhou NHLBI University of Cambridge

19 NATIONAL INSTITUTES OF HEALTH

POSTERS

1 6 A Novel Continuous-Perfusion Rotating Wall Vessel Emerging Pathogenic Unit of Vesicle-Cloaked Bioreactor for Optimized Culture of Retinal Organoids Norovirus Clusters are Resistant to Environmental Michael A. Phelan, Peter I. Lelkes, Anand Swaroop Stresses and Disinfection Graduate Student: Michael A. Phelan Mengyang Zhang, Sourish Ghosh, Manish Kumar, Marianita NIH Institute-Center: NEI Santiana, Natthawan Chaimongkol, Nihal Altan-Bonnet, NIH Research Advisor: Dr. Anand Swaroop Danmeng Shuai University Research Advisor: Dr. Peter I. Lelkes Graduate Student: Mengyang Zhang Graduate University: Temple University NIH Institute-Center: NHLBI NIH Research Advisor: Dr. Nihal Altan-Bonnet 2 University Research Advisor: Dr. Danmeng Shuai Unexpected Pathways of Cell Stress Response to Graduate University: George Washington University Procollagen Misfolding in Osteoblasts Laura Gorrell, Elena Makareeva, Shakib Omari, 7 Sergey Leikin Group 1 Innate Lymphoid Cell-Derived Interferon- Graduate Student: Laura M. Gorrell gamma Maintains Anti-Viral Vigilance in the Mucosal NIH Institute-Center: NICHD Epithelium NIH Research Advisor: Dr. Sergey Leikin John P. Shannon, Sophia M. Vrba, Glennys V. Reynoso, Erica University Research Advisor: Dr. Mariah Hahn Wynne-Jones, Olena Kamenyeva, Courtney S. Malo, Christian Graduate University: Rensselaer Polytechnic Institute R. Cherry, Daniel T. McManus, Heather D. Hickman Graduate Student: John P. Shannon 3 NIH Institute-Center: NIAID Genetic Analysis of the Modern Australian Labradoodle NIH Research Advisor: Dr. Heather D. Hickman Dog Breed Reveals an Excess of the Poodle Genome University Research Advisor: Dr. Geoffrey L. Smith Muhammad Basil Ali, Jacquelyn M. Evans, Heidi G. Parker, Graduate University: University of Cambridge Jaemin Kim, Susan Pearce-Kelling, D. Thad Whitaker, Jocelyn Plassais, Qaiser M. Khan, Elaine A. Ostrander 8 Graduate Student: Muhammad Basil Ali Saturated Fatty Acids Activate the NLRP3 NIH Institute-Center: NHLBI Inflammasome in Macrophages through a Pathway NIH Research Advisor: Dr. Elaine A. Ostrander Distinct from Both Classical and Non-canonical University Research Advisor: Dr. Qaiser M. Khan Inflammasome Activation Graduate University: National Institute for Biotechnology and Jonathan J. Liang, Clinton J. Bradfield, Clare E. Bryant, Genetic Engineering (NIBGE) Iain D.C. Fraser Graduate Student: Jonathan J. Liang 4 NIH Institute-Center: NIAID Ablation of the ZCCHC8 Subunit of the Nuclear Exosome NIH Research Advisor: Dr. Iain D.C. Fraser Targeting Complex Inhibits Degradation of Pervasive University Research Advisor: Prof. Clare E. Bryant Transcripts from Predicted Genes, RIKEN cDNAs, and Graduate University: University of Cambridge Genomic Regulatory Features Joshua W. Collins, Kenneth M. Yamada 9 Graduate Student: Joshua W. Collins Cell-free DNA Maps the Sources of Tissue Injury and NIH Institute-Center: NIDCR Identifies COVID-19 Patients at Risk of Death NIH Research Advisor: Dr. Kenneth M. Yamada Temesgen E. Andargie, Moon Kyoo Jang, Fayaz Seifuddin, University Research Advisor: Dr. Trina Schroer Hyesik Kong, Ilker Tunc, Komudi Singh, Alison Grazioli, Graduate University: Johns Hopkins University Steven Nathan, Mehdi Pirooznia, Sean Agbor-Enoh Graduate Student: Temesgen E. Andargie 5 NIH Institute-Center: NHLBI Cis- and Trans- Influences of Tandem Repeat NIH Research Advisor: Dr. Sean Agbor-Enoh Polymorphisms on Gene Networks in Human Brain University Research Advisor: Dr. Clarence M. Lee Dylan G. Sucich, Colin A. Hodgkinson, Qiaoping Yuan, Graduate University: Howard University Pei-Hong Shen, Yonwoo Jung, Ajeet Mandel, Stefano Marenco, David Goldman Graduate Student: Dylan G. Sucich NIH Institute-Center: NIAAA NIH Research Advisor: Dr. David Goldman Graduate University: Johns Hopkins University

20 GRADUATE STUDENT RESEARCH SYMPOSIUM 2021

POSTERS

10 15 Intrinsic Role of STAT3 for Efficient Gammaherpesvirus Mitochondrial Oxidative Dysfunction Does Not Latency Establishment Correlate with Disease Severity in a Drosophila Model Chad H. Hogan, Camille Khairallah, Brian Sheridan, of Age-Related Neurodegeneration Laurie T. Krug Andrew P. K. Wodrich, Arvind K. Shukla, Edward Giniger Graduate Student: Chad H. Hogan Graduate Student: Andrew P. K. Wodrich NIH Institute-Center: NCI NIH Institute-Center: NINDS NIH Research Advisor: Dr. Laurie T. Krug NIH Research Advisor: Dr. Edward Giniger University Research Advisor: Dr. Adrianus van der Velden University Research Advisor: Dr. Brent Harris Graduate University: Stony Brook University Graduate University: Georgetown University

11 16 Nucleus Accumbens Dopamine D3 Receptor Regulates Novel Metabolomic Signature Predicts Information Processing and Motivated Behavior Pheochromocytoma and Paraganglioma Metastasis Juan Enriquez-Traba, Hector Yarur-Castilllo, Rodolfo Flores- Yasemin Cole, Eamonn Maher, Ruth Casey, Zhengping Zhuang Garcia, Huikun Wang, Hugo Tejeda Graduate Student: Yasemin Cole Graduate Student: Juan Enriquez-Traba NIH Institute-Center: NCI NIH Institute-Center: NIMH NIH Research Advisor: Dr. Zhengping Zhuang NIH Research Advisor: Dr. Hugo Tejeda University Research Advisor: Dr. Eamonn Maher University Research Advisor: Dr. Rosario Moratalla Graduate University: University of Cambridge Graduate University: Universidad Autonoma de Madrid 17 12 The Effect of Metformin in MEN1 Related-Pancreatic Serotonergic Effects on Orbitofrontal Cortex Neuroendocrine Tumors Parvalbumin Neurons Expressing Cre Recombinase Akua Graf, Aisha A. Tepede, David J. Venzon, Maya E. Lee, are Unchanged after Withdrawal from Cocaine Self- Sunita K. Agarwal, Craig Cochran, William F. Simonds, Lee S. Administration in Rats Weinstein, Jenny E. Blau, Jaydira Del Rivero Andrew M. Wright, Alexander F. Hoffman, Brandon K. Graduate Student: Akua Graf Harvey, Carl R. Lupica NIH Institute-Center: NIDDK Graduate Student: Andrew M. Wright NIH Research Advisor: Dr. Jaydira Del Rivero NIH Institute-Center: NIDA University Research Advisor: Dr. Janine Sacco NIH Research Advisor: Dr. Carl R. Lupica Graduate University: University of Illinois, Chicago University Research Advisor: Dr. Barry Connors Graduate University: Brown University 18 Investigating the Epigenetic Regulation of Malignant 13 Peripheral Nerve Sheath Tumors Neuroinflammation Driven by Activated Rho-associated Béga Murray, Xiyuan Zhang, Shahroze Abbas, Jack Shern Protein Kinase 2 (ROCK2) Graduate Student: Béga Murray Elliot Glotfelty, Yazhou Li, David Tweedie, Tobias Karlsson, NIH Institute-Center: NCI Lars Olson, Nigel Greig NIH Research Advisor: Dr. Jack Shern Graduate Student: Elliot Glotfelty University Research Advisor: Dr. Jaine Blayney NIH Institute-Center: NIA Graduate University: Queen's University Belfast NIH Research Advisor: Dr. Nigel Greig University Research Advisor: Dr. Lars Olson 19 Graduate University: Karolinska Institutet Exploring the Synergistic Effect of Energy Restriction and Metformin in Colorectal Cancer Models 14 María Castejón-Mariscal de Gante, Andrés Pastor-Fernández, Deciphering Specific Sensory Circuits Controlling Paula Ostos-Arellanos, Lorena Blanco-Calcerrada, Pablo Secretory Function Jose Fernandez-Marcos, Rafael de Cabo, Alberto Diaz-Ruiz Julia A. Licholai, Joshua J. Emrick, Nicholas J. P. Ryba Graduate Student: Maria Castejon-Mariscal de Gante Graduate Student: Julia A. Licholai NIH Institute-Center: NIA NIH Institute-Center: NIDCR NIH Research Advisor: Dr. Rafael de Cabo NIH Research Advisor: Dr. Nicholas Ryba University Research Advisor: Dr. Alberto Diaz-Ruiz Graduate University: Brown University Graduate University: IMDEA Food-Universidad Autonoma de Madrid

21 NATIONAL INSTITUTES OF HEALTH

POSTERS

20 25 Evaluating the Role of MDSCs in the Ovarian Cancer TGF-βsignal controls the development of CD8αα+γδτ Tumor Microenvironment Intestinal Intraepithelial Lymphocytes Franklin Ning, Christina Annunziata Jiajia Han, Andrew Bynum, Wenwen Jin, Jianming Zhang, Graduate Student: Franklin Ning Wei He, Wanjun Chen NIH Institute-Center: NCI Graduate Student: Jiajia Han NIH Research Advisor: Dr. Christina Annunziata NIH Institute-Center: NIDCR University Research Advisor: Dr. Nevil Singh NIH Research Advisor: Dr. Wanjun Chen Graduate University: University of Maryland, Baltimore University Research Advisor: Dr. Wei He Graduate University: Peking Union Medical Colleage 21 GPC3 is a Potent Target for Immunotherapy Using 26 Engineered, Nanobody-Based CAR T Cells Characterization of Immune Behavior in Health and Aarti Kolluri, Dan Li, Nan Li, Mitchell Ho Development of 3-D Bioprinted RPE/Choroid Graduate Student: Aarti Kolluri Russell Quinn, Min Jae Song, Rafael Villasmil, Julie Laux, NIH Institute-Center: NCI Ty Voss, Anju Singh, Eric Nguyen, Tea-Soon Park Devika NIH Research Advisor: Dr. Mitchell Ho Bose, Marc Ferrer, Kapil Bharti University Research Advisor: Dr. Lewis Roberts Graduate Student: Russell Quinn Graduate University: Mayo Clinic Graduate School of NIH Institute-Center: NEI Biomedical Sciences NIH Research Advisor: Dr. Kapil Bharti University Research Advisor: Dr. Xin Chen and 22 Dr. Andrew Gordus Imageable Gels as Drug Delivery Platforms for the Graduate University: Johns Hopkins University Treatment of Liver Cancer Jose F. Delgado, Andrew S. Mikhail, Michal Mauda Havakuk, 27 Joshua W. Owen, Robert Morhard, William F. Pritchard, Characterization of a Unique σ70 Variant of an John W. Karanian, Bradford J. Wood Adherent Invasive Escherichia coli, LF82, a Pathobiont Graduate Student: Jose F. Delgado Associated with Crohn’s Disease NIH Institute-Center: CC Melissa Arroyo-Mendoza, Abraham Correa-Medina, NIH Research Advisor: Dr. Bradford J. Wood Nicholas Backes, Gregory Phillips, Deborah Hinton University Research Advisor: Dr. Huang-Chiao Huang Graduate Student: Melissa Arroyo-Mendoza Graduate University: University of Maryland, College Park NIH Institute-Center: NIDDK NIH Research Advisor: Dr. Deborah M. Hinton 23 University Research Advisor: Dr. Gregory Phillips B Cell-Intrinsic Complement Activity in the Primary Graduate University: Iowa State University Immune Response Daniel K. Lundgren, Menna R. Clatworthy, Claudia Kemper 28 Graduate Student: Daniel K. Lundgren Systemic Administration of AAV5/AAV8-Hps1 to NIH Institute-Center: NHLBI Prevent Hermansky-Pudlak Syndrome-Associated NIH Research Advisor: Dr. Claudia Kemper Pulmonary Fibrosis in Mice University Research Advisor: Prof. Menna R. Clatworthy Shachar Abudi, Marina Zieger, John Burke, Payam Graduate University: University of Cambridge Khoshkenar, Lisa J. Garrett, Yair Anikster, William A. Gahl, Christian Mueller, Bernadette Gochuico, May C. Malicdan 24 Graduate Student: Shachar Abudi The Role of Glycosphingolipids in Lymphocyte Biology NIH Institute-Center: NHGRI Hannah Dada, Tasha Morrison, John O'Shea NIH Research Advisor: Dr. William Gahl Graduate Student: Hannah Dada University Research Advisor: Prof. Yair Anikster NIH Institute-Center: NIAMS Graduate University: Tel Aviv University NIH Research Advisor: Dr. John O'Shea University Research Advisor: Dr. Michael Dustin 29 Graduate University: University of Oxford Apoptosis Induced Nuclear Bursting in Tumor Cells Drives S100A4 Mediated Metastatic Outgrowth Justin M. Gray, Woo Yong Park, Li Yang Graduate Student: Justin M. Gray NIH Institute-Center: NCI NIH Research Advisor: Dr. Li Yang Graduate University: Johns Hopkins University 22 GRADUATE STUDENT RESEARCH SYMPOSIUM 2021

POSTERS

30 34 Sleep Midpoint, Night Shift Work and Japanese Atomic Bomb Survivor Dosimetry Using Risk of Anovulation among Eumenorrheic, the J45 Phantom Series: Comprehensive Source Reproductive-Aged Women Term Modelling Joshua R. Freeman, Brian W. Whitcomb, Elizabeth R. Keith T. Griffin, Tatsuhiko Sato, Sachiyo Funamoto, Bertone-Johnson, Laura B. Balzer, Keewan Kim, Alexandra Konstantin Chizhov, Sean Domal, Colin Paulbeck, C. Purdue-Smithe, Robert M. Silver, Enrique F. Schisterman, Wesley Bolch, Harry Cullings, Stephen Egbert, Sunni L. Mumford Akira Endo, Nolan Hertel, Choonsik Lee Graduate Student: Joshua R. Freeman Graduate Student: Keith T. Griffin NIH Institute-Center: NICHD NIH Institute-Center: NCI NIH Research Advisor: Dr. Sunni L. Mumford NIH Research Advisor: Dr. Choonsik Lee University Research Advisor: Dr. Brian W. Whitcomb University Research Advisor: Dr. Nolan Hertel Graduate University: University of Massachusetts, Amherst Graduate University: Georgia Institute of Technology

31 35 Prescription Opioid Use and Risk for Major Depressive PI3K-Effector Targeted CRISPR-Screen Identifies Rasa3 Disorder and Anxiety and Stress-Related Disorders: a as Regulator of LFA1-Activation in T Cells Multivariable Mendelian Randomization Study Kristoffer Harum Johansen, Dominic Golec, Bonnie Huang, Daniel B. Rosoff, George Davey Smith, Falk W. Lohoff Julie Hagedorn Thomsen, Silvia Preite, Jennifer Cannons, Graduate Student: Daniel B. Rosoff James Phelan, Fabien Garçon, Julie Reilley, Wolfgang NIH Institute-Center: NIAAA Bergmeier, Klaus Okkenhaug, Pamela Schwartzberg NIH Research Advisor: Dr. Falk W. Lohoff Graduate Student: Kristoffer Haurum Johansen University Research Advisor: Dr. Michael V. Holmes NIH Institute-Center: NIAID Graduate University: University of Oxford NIH Research Advisor: Dr. Pamela L. Schwartzberg University Research Advisor: Dr. Klaus Okkenhaug 32 Graduate University: University of Cambridge Associations between Exposure to Gestational Diabetes Mellitus and Newborn DNA Methylation 36 Stephanie Chidester, Sonia L. Robinson, Xuehuo Zeng, Microbiota-Immune Crosstalk Mediates Anticancer Weihua Guan, Rajeshwari Sundaram, Paule V. Joseph, Erin Effects of Dietary Fiber M. Bell, Edwina H. Yeung Khiem C. Lam, Romina E. Araya, April Huang, Quanyi Chen, Graduate Student: Stephanie Chidester Richard R. Rodrigues, Romina S. Goldszmid NIH Institute-Center: NINR Graduate Student: Khiem C. Lam NIH Research Advisor: Dr. Paule V. Joseph NIH Institute-Center: NCI University Research Advisor: Dr. Anne F. Fish NIH Research Advisor: Dr. Romina S. Goldszmid Graduate University: University of Missouri, St. Louis University Research Advisor: Dr. Najib El-Sayed Graduate University: University of Maryland, College Park 33 Acceleration of Lipid Force Field Parameterization by 37 Machine Learning Measuring Leukocyte Trafficking Kinetics in Macaques Yalun Yu, Andreas Krämer, Richard M. Venable, Andrew C. using Serial Intravascular Staining Simmonett, Jeffery B. Klauda, Bernard R. Brooks, E. Lake Potter, Hannah P. Gideon, Victor Tkachev, Giulia Richard W. Pastor Fabozzi, Alexander Chassiakos, Constantinos Petrovas, Graduate Student: Yalun Yu Patricia A. Darrah, Philana Ling Lin, Kathryn E. Foulds, NIH Institute-Center: NHLBI Leslie S. Kean, JoAnne L. Flynn, Mario Roederer NIH Research Advisor: Dr. Richard W. Pastor Graduate Student: E. Lake Potter University Research Advisor: Dr. Jeffery B. Klauda NIH Institute-Center: VRC Graduate University: University of Maryland, College Park NIH Research Advisor: Dr. Mario Roederer Graduate University: Johns Hopkins University

23 NATIONAL INSTITUTES OF HEALTH

POSTERS

38 43 Evaluation of FcμR as a Specific Target for the A Role for Adult Neurogenesis in a Probabilistic Treatment of Chronic Lymphocytic Leukemia Learning Task A. Fulfulan, D. Hwang, C. Rader, A. Wiestner, S. Baskar Kathleen B. Huntzicker, Rose-Marie Karlsson, Graduate Student: Amro A. Fulfulan Heather A. Cameron NIH Institute-Center: NHLBI Graduate Student: Kathleen B. Huntzicker NIH Research Advisor: Dr. Adrian Wiestner NIH Institute-Center: NIMH University Research Advisor: Dr. Katia Nestorovich NIH Research Advisor: Dr. Heather A. Cameron Graduate University: Catholic University of America Graduate University: Brown University

39 44 Observational Fear Learning: From Mouse to Man Role of L5 V1 Corticostriatal Neurons in Performance Shana Silverstein, Julia Schaffer, Vincent Valton, Jonathan and Learning of a Perceptual Task Roiser, Essi Viding, Andrew Holmes Hannah C. Goldbach, Jonathan F. O'Rawe, Mark H. Histed Graduate Student: Shana Silverstein Graduate Student: Hannah C. Goldbach NIH Institute-Center: NIAAA NIH Institute-Center: NIMH NIH Research Advisor: Dr. Andrew Holmes NIH Research Advisor: Dr. Mark Histed University Research Advisor: Dr. Jonathan Roiser Graduate University: Brown University and Dr. Essi Viding Graduate University: University College London 45 Does Replay in the Awake Human Brain Encode 40 Experience as a Sequence of Sequences Racial/Ethnic Discrimination and Intimate Partner Jiali Zhang, John H. Wittig, Jr., Sara K. Inati, Violence Perpetration in Latino Men: The Mediating Timothy E.J. Behrens, Kareem A. Zaghloul Effects of Mental Health Graduate Student: Jiali Zhang Ana I. Maldonado, Carol B. Cunradi, Anna M. Nápoles NIH Institute-Center: NINDS Graduate Student: Ana Maldonado NIH Research Advisor: Dr. Kareem Zaghloul NIH Institute-Center: NIMHD University Research Advisor: Dr. Tim Behrens NIH Research Advisor: Dr. Anna M. Nápoles Graduate University: University of Oxford University Research Advisor: Dr. Christopher M. Murphy Graduate University: University of Maryland, 46 Baltimore County Roles for the RhoGEF Trio in Axon Guidance and Dendrite Patterning 41 Erin Fingleton, Jeremiah D. Paskus, Katherine W. Roche Combinatorial Therapy to Boost Neuronal Regeneration Graduate Student: Erin Fingleton while Inhibiting Dual Leucine Zipper Kinase in a Mouse NIH Institute-Center: NINDS Model of ALS NIH Research Advisor: Dr. Katherine W. Roche Josette J. Wlaschin, Caroline Donahue, Jacob M. Gluski, Graduate University: Brown University Jennifer Osborne, Leanna Ramos, Hanna Silberberg, Claire E. Le Pichons 47 Graduate Student: Josette J. Wlaschin Brain Network Dynamics in the Transition from NIH Institute-Center: NICHD Wakefulness to Sleep NIH Research Advisor: Dr. Claire E. Le Pichon Samika Kumar, Pedro Mediano, Javier Gonzalez-Castillo, Graduate University: Johns Hopkins University Isabel Fernandez, Enzo Tagliazucchi, Corinne Bareham, Anat Arzi, Peter Bandettini, Tristan Bekinschtein 42 Graduate Student: Samika Kumar Measuring Temporal and Spatial Neurochemical NIH Institute-Center: NIMH Changes in the Human Brain NIH Research Advisor: Dr. Peter Bandettini Jacob M. Levenstein, Justin Andrushko, Betina Ip, William University Research Advisor: Dr. Tristan Bekinschtein Clarke, Uzay Emir, Peter Bandettini, Charlotte J. Stagg Graduate University: University of Cambridge Graduate Student: Jacob M. Levenstein NIH Institute-Center: NIMH NIH Research Advisor: Dr. Peter Bandettini University Research Advisor: Prof. Charlotte J. Stagg Graduate University: University of Oxford

24 GRADUATE STUDENT RESEARCH SYMPOSIUM 2021

POSTERS

48 53 Cellular Mechanisms Underlying Socially Influenced A Requirement for Abundance Limits the Functional Modulation of Feeding Behavior piRNA Sequence Space and Ensures Non-Self Ivan C. Alcantara, Michael J. Krashes Specificity in the Germline Graduate Student: Ivan C. Alcantara Parthena Konstantinidou, Pavol Genzor, Daniel Stoyko, Amir NIH Institute-Center: NIDDK Manzourolajdad, Celine R. Marlin Andrews, Constantinos NIH Research Advisor: Dr. Michael J. Krashes Stathopoulos, Markus Hafner, Astrid D. Haase University Research Advisor: Dr. Gilad Barnea Graduate Student: Parthena Konstantinidou Graduate University: Brown University NIH Institute-Center: NIDDK NIH Research Advisor: Dr. Astrid D. Haase 49 University Research Advisor: Dr. Constantinos Stathopoulos How UPF1 Helicase Activity Converts its Non-Specific Graduate University: University of Patras mRNA Interactions into Targeted Decay Joseph H. Chapman, Jonathan M. Craig, Clara D. Wang, 54 Jens H. Gundlach, Keir C. Neuman, J. Robert Hogg Targeted Long-Read Sequencing of the Ewing Sarcoma Graduate Student: Joseph H. Chapman 6p25.1 Susceptibility Locus Identifies Polymorphic NIH Institute-Center: NHLBI GGAA Microsatellite Associated with EWSR1-FLI1 NIH Research Advisor: Dr. J. Robert Hogg and Dr. Keir C. Fusion Binding Neuman Olivia W. Lee, Shu-Hong Lin, Wen Luo, Kristine Jones, Graduate University: Johns Hopkins University Derek W. Brown, Sairah M. Khan, Gregory T. Armstrong, Smita Bhatia, Leslie L. Robison, Yutaka Yasui, Uta Dirksen, 50 Laura Romero-Pérez, Wolfgang Hartmann, Markus Metzler, Substate Stiffness Alters Chromatin Dynamics and Brian Carter, Neal Freedman, Robert Hoover, Lindsay Transcription Factor Binding Kinetics Morton, Stephen Chanock, Olivier Delattre, Thomas G.P. Kaustubh Wagh, David A. Garcia, Diana A. Stavreva, Grünewald, Mitchell Machiela Arpita Upadhyaya, Gordon L. Hager Graduate Student: Olivia W. Lee Graduate Student: Kaustubh Wagh NIH Institute-Center: NCI NIH Institute-Center: NCI NIH Research Advisor: Dr. Mitchell Machiela NIH Research Advisor: Dr. Gordon L. Hager and Dr. Stephen Chanock University Research Advisor: Dr. Arpita Upadhyaya University Research Advisor: Dr. John N. Weinstein Graduate University: University of Maryland, College Park Graduate University: University of Texas, MD Anderson Cancer Center 51 55 Membrane Targeting Activates LRRK2 with Differential Effects on Downstream Rab Activation Identifying the Landscape of Intratumoral Microbes via Jillian H. Kluss, Alexandra Beilina, Patrick A. Lewis, a Single Cell Transcriptomic Analysis Mark R. Cookson, Luis Bonet-Ponce Welles Robinson, Fiorella Schischlik, E. Michael Gertz, Graduate Student: Jillian H. Kluss Alejandro A. Schaffer, Eytan Ruppin NIH Institute-Center: NIA Graduate Student: Welles Robinson NIH Research Advisor: Dr. Mark R. Cookson NIH Institute-Center: NCI University Research Advisor: Dr. Patrick A. Lewis NIH Research Advisor: Dr. Eytan Ruppin Graduate University: University of Reading Graduate University: University of Maryland, College Park

52 56 The ETS Transcription Factor ERF Controls the Exit Dissecting Tumor Clonality to Understand Intra- and from the Embryonic Rosette-Stage of Pluripotency Inter-Tumor Heterogeneity in Liver Cancer Maria Vega-Sendino, Teresa Olbrich, Desiree Tillo, Zeynep Kacar, Julián Candia, Doron Levy, Eric V. Slud, Andy D. Tran, Catherine N. Domingo, Mariajose Franco, Xin W. Wang Peter C. FitzGerald, Michael J. Kruhlak, Sergio Ruiz Graduate Student Name: Zeynep Kacar Graduate Student: Maria Vega-Sendino NIH Institute-Center: NCI NIH Institute-Center: NCI NIH Research Advisor: Dr. Xin W. Wang NIH Research Advisor: Dr. Sergio Ruiz University Research Advisor: Dr. Eric V. Slud University Research Advisor: Dr. Marta Perez Pereira Graduate University: University of Maryland, College Park Graduate University: Universidad Autónoma de Madrid

25 NATIONAL INSTITUTES OF HEALTH

POSTERS

57 61 TP53 Pathway Function, Estrogen Receptor Status, Plasmodium yoelii 17XNL Infection Induces and Breast Cancer Risk Factors in the Carolina Breast Macrophage Dysfunction and Blockage of Erythrocyte Cancer Study Maturation Amber N. Hurson, Mustapha Abubakar, Katherine Hoadley, Keyla C. Tumas, Jian Wu, Sittiporn Pattaradilokrat, Yu-chih Kathleen Conway-Dorsey, Michael I. Love, Andrew F. Olshan, Peng, Angela Musu Lavali, Lu Xia, Xiao He, Brajesh K. Singh, Montserrat Garcia-Closas, Melissa A. Troester Cui Zhang, Chen-Feng Qi, Suming Huang, Carole A. Long, Graduate Student: Amber N. Hurson Xin-zhuan Su NIH Institute-Center: NCI Graduate Student: Keyla C. Tumas NIH Research Advisor: Dr. Montserrat Garcia-Closas NIH Institute-Center: NIAID University Research Advisor: Dr. Melissa Troester NIH Research Advisor: Dr. Xin-zhuan Su Graduate University: University of North Carolina, Chapel Hill University Research Advisor: Dr. Steven Singer Graduate University: Georgetown University 58 Integrated Analysis of Inflammation-Related Exposures 62 in Ovarian Cancer Histotypes in the Ovarian Cancer gp120-Mediated CD4+ T Cell Activation is Inhibited by Association Consortium (OCAC) Non-Neutralizing V2 Loop Antibodies Sarah R. Irvin, Britton Trabert, Joshua Sampson, Sinmanus Vimonpatranon, Livia Goes, Donald Van Ryk, OCAC members, Nicolas Wentzensen Danlan Wei, Claudia Cicala, Kovit Pattanapanyasat, Graduate Student: Sarah R. Irvin Constantinos Kurt Wibmer, Lynn Morris, Marcelo A. Soares, NIH Institute-Center: NCI Anthony S. Fauci, James Arthos NIH Research Advisor: Dr. Nicolas Wentzensen Graduate Student: Sinmanus Vimonpatranon University Research Advisor: Dr. Cher Dallal NIH Institute-Center: NIAID Graduate University: University of Maryland, College Park NIH Research Advisor: Dr. James Arthos University Research Advisor: Prof. Kovit Pattanapanyasat 59 Graduate University: Mahidol University Metabolic and Structural Muscular Changes Driven by Chronic Disease-Like IFN-g Exposure 63 John Fenimore, Danielle Springer, Julio Valencia, Cell Culture Approaches to Examine the Mechanism Elijah Edmonston, Rebecca Erwin-Cohen, Howard Young of the MHV68 Uracil DNA Glycosylase and dUTPase Graduate Student: John M. Fenimore during Viral Replication NIH Institute-Center: NCI Kyle R. Smith, QIwen Dong, Laurie T. Krug NIH Research Advisor: Dr. Howard Young Graduate Student: Kyle R. Smith University Research Advisor: Dr. Michelle Starz-Gaiano NIH Institute-Center: NCI Graduate University: University of Maryland, Baltimore NIH Research Advisor: Dr. Laurie T. Krug County University Research Advisor: Dr. Patrick Hearing Graduate University: Stony Brook University 60 Restoration of a GxxxG Motif in Human IFITM5 64 Potentiates its Oligomerization Capacity and Antiviral Neuronal Morphology Imposes a Tradeoff between Activity Stability, Accuracy and Efficiency of Synaptic Scaling Charles A. Coomer, Alex A. Compton Adriano A. Bellotti, Timothy O'Leary, Dax Hoffman Graduate Student: Charles A. Coomer Graduate Student: Adriano A. Bellotti NIH Institute-Center: NCI NIH Institute-Center: NICHD NIH Research Advisor: Dr. Alex A. Compton NIH Research Advisor: Dr. Dax Hoffman University Research Advisor: Dr. Sergi Padilla-Parra University Research Advisor: Dr. Timothy O'Leary Graduate University: University of Oxford Graduate University: University of Cambridge

26 GRADUATE STUDENT RESEARCH SYMPOSIUM 2021

POSTERS

65 70 Human Cortical Ripples Reflect a Spectrum of Prolonged Infectious SARS-CoV-2 Shedding from an Synchronous Spiking Activity across Spatial Scale Immunocompromised Patient with Cancer Ai Phuong S. Tong, Alex P. Vaz, Sara K. Inati, Victoria A. Avanzato, M. Jeremiah Matson, Stephanie N. Kareem A. Zaghloul Seifert, Rhys Pryce, Brandi N. Williamson, Sarah L. Anzick, Graduate Student: Ai Phuong S. Tong Kent Barbian, Seth D. Judson, Elizabeth R. Fischer, NIH Institute-Center: NINDS Craig Martens, Thomas A. Bowden, Emmie de Wit, NIH Research Advisor: Dr. Kareem A. Zaghloul Francis X. Riedo, Vincent J. Munster Graduate University: University of Oxford Graduate Student: Victoria A. Avanzato NIH Institute-Center: NIAID 66 NIH Research Advisor: Dr. Vincent J. Munster Characterizing Response Heterogeneity and Adaptation University Research Advisor: Dr. Thomas A. Bowden in Olfactory Receptor Neurons Graduate University: University of Oxford Brian Kim, Seth Haney, Zane Aldworth, Maxim Bazhenov, Mark Stopfer 71 Graduate Student: Brian Kim One Small Step for a Man; One Giant Leap for NIH Institute-Center: NICHD Mankind: How Miniaturized 3D Tissue Models Can NIH Research Advisor: Dr. Mark Stopfer Help Accelerate Therapeutics Development and Graduate University: Brown University Understanding of Disease Pathomechanism Olive Jung, Yen-Ting Tung, Emily Lee, Srikanya Kundu, Andy 67 Vo, Molly Boutin, Marc Ferrer, Min Jae Song An Exact Hyper Graph Matching Algorithm for Nuclear Graduate Student: Olive Jung Identification in Embryonic Caenorhabditis elegans NIH Institute-Center: NCATS Andrew Lauziere, Ryan Christiansen, Hari Shroff NIH Research Advisor: Dr. Marc Ferrer Graduate Student: Andrew Lauziere University Research Advisor: Dr. Eleanor Stride NIH Institute-Center: NIBIB Graduate University: University of Oxford NIH Research Advisor: Dr. Hari Shroff University Research Advisor: Dr. Radu Balan 72 Graduate University: University of Maryland, College Park Increased Tumor Plasticity Predicts Resistance to CD19 CAR T Cell Therapy in Pre-Treatment Pediatric 68 Acute Lymphoblastic Leukemia Characterizing the Excitatory Physiology of a Small Katherine E. Masih, Rebecca Gardner, David Milewski, Field Retinal Ganglion Cell Abdalla Abdelmaksoud, Hsien-Chao Chou, Brittany Sincox, Jeffrey Diamond Vineela Gangalapudi, Berkley E. Gryder, Serifat Adebola, Graduate Student: Brittany Sincox Ashley L. Wilson, Benjamin Z. Stanton, Young K. Song, NIH Institute-Center: NINDS Chaoyu Wang, Xinyu Wen, Zachary Rae, Allison Ruchinskas, NIH Research Advisor: Dr. Jeffrey Diamond Adam Cheuk, Justin Lack, Grégoire Altan-Bonnet, University Research Advisor: Dr. Stuart Cull-Candy Michael Kelly, Jun S. Wei, Michael C. Jensen, Rimas J. Graduate University: University College London Orentas, Javed Khan Graduate Student: Katherine E. Masih NIH Institute-Center: NCI 69 NIH Research Advisor: Dr. Javed Khan Neutralization of EBV by Monoclonal Antibodies is Dose University Research Advisor: Prof. Richard J. Gilbertson Dependent on the Level of CD21 on Target Cells Graduate University: University of Cambridge JungHyun Kim, Wei Bu, M. Gordon Joyce, Masaru Kanekiyo, Jeffrey I. Cohen 73 Graduate Student: JungHyun Kim NIH Institute-Center: NIAID Rhesus Macaque as a Preclinical Model Organism of NIH Research Advisor: Dr. Jeffrey I. Cohen RUNX1-FPD and Gene Therapy University Research Advisor: Dr. Xiaoping Zhu Yifan Zhou, Erica Bresciani, Neval Ozkaya, Paul Liu, Graduate University: University of Maryland, College Park Cynthia Dunbar Graduate Student: Yifan Zhou NIH Institute-Center: NHLBI NIH Research Advisor: Dr. Cynthia Dunbar University Research Advisor: Dr. George Vassiliou Graduate University: University of Cambridge

27 NATIONAL INSTITUTES OF HEALTH

POSTERS

74 79 Towards Mechanistic Understanding of Mitochondrial Patient Mutation in CHCHD10 Causes Cardiomyopathy, β-barrel Biogenesis: Structural Studies of the Sorting Multiple mtDNA Deletions and OMA1 Activation and Assembly Machinery Mario K. Shammas, Xiaoping Huang, Danielle Springer, Kathryn A. Diederichs, Xiaodan Ni, Sarah E. Rollauer, Carlos Lopez-Otin, Joanna Poulton, Derek P. Narendra Istvan Botos, Xiofeng Tan, Martin S. King, Edmund R. S. Graduate Student: Mario K. Shammas Kunji, Jiansen Jiang, Joseph A. Mindell, Susan K. Buchanan NIH Institute-Center: NINDS Graduate Student: Kathryn A. Diederichs NIH Research Advisor: Dr. Derek Narendra NIH Institute-Center: NIDDK University Research Advisor: Prof. Patrick Chinnery NIH Research Advisor: Dr. Susan K. Buchanan Graduate University: University of Cambridge Graduate University: Johns Hopkins University 80 75 Exploring the Genotype-Phenotype Relationships of Estimating Transition Path Times and Shapes from Patient-Specific PNPLA6 Mutations Single-Molecule Photon Trajectories: A Simulation James Liu, Cara Lwin, Tongyi Dou, Lijin Dong, Bin Guan, Analysis Rob Hufnagel Grace H. Taumoefolau, Robert B. Best Graduate Student: James Liu Graduate Student: Grace Hikari Taumoefolau NIH Institute-Center: NEI NIH Institute-Center: NIAAA NIH Research Advisor: Dr. Robert Hufnagel NIH Research Advisor: Dr. Robert B. Best Graduate University: Johns Hopkins University Graduate University: Johns Hopkins University 81 76 Understanding Craniofacial Development through Mass Global Alignment and Assessment of TRP Channel Spectrometry Based Proteomics Structures to Explore Functional Mechanisms Leena Pade, Jaeho Yoon, Ira Daar, Peter Nemes Katherine E. Huffer, Antoniya A. Aleksandrova, Graduate Student: Leena Pade Andres Jara-Oseguera, Lucy R. Forrest, Kenton J. Swartz NIH Institute-Center: NCI Graduate Student: Katherine E. Huffer NIH Research Advisor: Dr. Ira Daar NIH Institute-Center: NINDS University Research Advisor: Dr. Peter Nemes NIH Research Advisor: Dr. Kenton J. Swartz Graduate University: University of Maryland, College Park University Research Advisor: Dr. Karen Fleming Graduate University: Johns Hopkins University 82 Mitochondrial Dysfunction in Ischemia-Reperfusion 77 Injury Real-Time Measurement of Time-Varying Diffusion Abigail V. Giles, Hiran A. Prag, Nils Burger, Thomas Krieg, Teddy X. Cai, Nathan H. Williamson, Velencia J. Witherspoon, Robert S. Balaban, Michael P. Murphy Rea Ravin, Peter J. Basser Graduate Student: Abigail V. Giles Graduate Student: Teddy X. Cai NIH Institute-Center: NHLBI NIH Institute-Center: NICHD NIH Research Advisor: Dr. Robert S. Balaban NIH Research Advisor: Dr. Peter J. Basser University Research Advisor: Dr. Michael P. Murphy University Research Advisor: Dr. Karla L. Miller Graduate University: University of Cambridge Graduate University: University of Oxford 83 78 Deep Learning Identification and Prognostication of Hair-Cell Neurotransmission Modulates Neomycin Tumor Infiltrating Lymphocytes in Breast Cancer Susceptibility Histology Images Daria Lukasz, Katie S. Kindt Aaron Bernstein, Paul Pharoah, Pietro Liò, Graduate Student: Daria Lukasz Montserrat García-Closas NIH Institute-Center: NIDCD Graduate Student: Aaron Bernstein NIH Research Advisor: Dr. Katie S. Kindt NIH Institute-Center: NCI Graduate University: Johns Hopkins University NIH Research Advisor: Dr. Montserrat García-Closas University Research Advisor: Dr. Paul Pharoah Graduate University: University of Cambridge

28 GRADUATE STUDENT RESEARCH SYMPOSIUM 2021

POSTERS

84 88 Genetic Diversity and Evolution of SARS-CoV-2 in the Vasoactive Intestinal Polypeptide Type-α Receptor United States (VIPR1) Mediated Signaling Inhibits Tumor Progression Adam A. Capoferri, Wei Shao, Jason W. Rausch, John M. by Regulating Pyrimidine Synthesis in Hepatocellular Coffin, Mary F. Kearney Carcinoma Graduate Student: Adam A. Capoferri Yaojie Fu, Yong He, Bin Gao NIH Institute-Center: NCI Graduate Student: Yaojie Fu NIH Research Advisor: Dr. Mary F. Kearney NIH Institute-Center: NIAAA Graduate University: Georgetown University NIH Research Advisor: Dr. Bin Gao University Research Advisor: Dr. Shan Zeng 85 Graduate University: Central South University Identifying Metabolic Immunomodulatory Mediators of Fasting and Refeeding: The Role of Short Chain Fatty 89 Acids Antibody-Drug Conjugate CRISPR/Cas9 Screens in the Allison Meadows, Matthew J. Rodman, Kim Han, DLBCL Cell Line TMD8 Reveal Regulators of the B-Cell Shahin Hassanzadeh, Komudi Singh, Mehdi Pirooznia, Receptor Rebecca D. Huffstutler, Ankit Saxena, J. Philip McCoy, Sean Corcoran, James Phelan, Sebastian Scheich, Art Fynn N. Krause, Julian L. Griffin, Michael N. Sack Shaffer, Ryan Young, Jaewoo Choi, Louis Staudt Graduate Student: Allison Meadows Graduate Student: Sean Corcoran NIH Institute-Center: NHLBI NIH Institute-Center: NCI NIH Research Advisor: Dr. Michael N. Sack NIH Research Advisor: Dr. Louis Staudt University Research Advisor: Dr. Julian L. Griffin University Research Advisor: Dr. Daniel Hodson Graduate University: University of Cambridge Graduate University: University of Cambridge

86 90 Pinpointing Cell States Induced by Vaccines using Analysis of Common Driver APOBEC-Type Mutations New Computational Tools for Multimodal Single Cell Implicates Viral Etiology in Bladder Cancer Analysis Nina Rao, Gabriel J. Starrett, Mary L. Piaskowski, Matthew P. Mulé, Andrew J. Martins, Foo Cheung, Kelly E. Butler, Yelena Golubeva, Wusheng Yan, Yuri Kotliarov, Rohit Farmer, Jinguo Chen, Neha Bansal, Scott Lawrence, Michael Dean, Montserrat Garcia-Closas, CHI Consortium, Pamela L. Schwartzberg, John S. Tsang Nuria Malats, Francisco X. Real, Manolis Kogevinas, Graduate Student: Matthew P. Mulè Nathaniel Rothman, Debra Silverman, Lars Dyrskjøt, NIH Institute-Center: NIAID Christopher B. Buck, NIH Research Advisor: Dr. John S. Tsang Stella Koutros, Ludmila Prokunina-Olsson University Research Advisor: Dr. Ken Smith Graduate Student: Nina Rao Graduate University: University of Cambridge NIH Institute-Center: NCI NIH Research Advisor: Dr. Ludmila Prokunina-Olsson and 87 Dr. Michael Dean The Utility of a Type 2 Diabetes (T2D) Polygenic Score Graduate University: Johns Hopkins University in Addition to Clinical Variables for Prediction of T2D Incidence across Age Groups 91 Lauren E. Wedekind, Anubha Mahajan, Wen-Chi Hsueh, Peng Patient-Derived Glioblastoma Cells Exhibit Distinct Chen, Muideen Olaiya, Sayuko Kobes, Leslie J. Baier, William Rheological Profiles Associated with Altered C. Knowler, Madhumita Sinha, Mark I. McCarthy, Cytoskeleton Regulatory Pathway Activity Robert L. Hanson Amelia Foss, Woong Young So, Michael Gottesman, Graduate Student: Lauren E. Wedekind Kandice Tanner NIH Institute-Center: NIDDK Graduate Student: Amelia Foss NIH Research Advisor: Dr. Robert L. Hanson NIH Institute-Center: NCI University Research Advisor: Dr. Mark I. McCarthy NIH Research Advisor: Dr. Kandice Tanner Graduate University: University of Oxford University Research Advisor: Dr. Manav Pathania Graduate University: Cambridge University

29 NATIONAL INSTITUTES OF HEALTH

POSTERS

92 97 Peroxidase Activity of PRDX6 as a Key Factor in Cell Probing Visual Perception Through Patterned Cycle Progression of a Hepatocarcinoma Cell Line Holographic Perturbations Daniel J. Lagal, Maria Jose Lopez-Grueso, Silvia Daza, Paul K. LaFosse, Yanting Deng, Victoria M. Scott, Raquel Requejo-Aguilar, Jose Antonio Barcena, Zhishang Zhou, Anna J. Li, Mark H. Histed Alicia Padilla, Thomas Leto Graduate Student: Paul K. LaFosse Graduate Student: Daniel J. Lagal NIH Institute-Center: NIMH NIH Institute-Center: NIAID NIH Research Advisor: Dr. Mark H. Histed NIH Research Advisor: Dr. Thomas Leto University Research Advisor: Dr. Behtash Babadi University Research Advisor: Dr. Alcia Padilla Graduate University: University of Maryland, College Park Graduate University: Universidad de Córdoba 98 93 Expression of the Glucocorticoid-Synthetic Enzyme Preserving Visual Signaling in the Degenerating Cyp11b1 in Mouse Ocular Tissue Mouse Retina Kaitlynn M. Donahue, Matthew D. Taves, Jonathan D. Ashwell Xiaoyi Li, William N. Grimes, Jeffrey S. Diamond Graduate Student: Kaitlynn M. Donahue Graduate Student: Xiaoyi Li NIH Institute-Center: NCI NIH Institute-Center: NINDS NIH Research Advisor: Dr. Jonathan D. Ashwell NIH Research Advisor: Dr. Jeffrey S. Diamond University Research Advisor: Dr. Mark Danielsen Graduate University: Johns Hopkins University Graduate University: Georgetown University

94 99 A Novel PET-Compatible Opsin for Translational Aedes aegypti Piwi4-RNA Binding Patterns Inform Optogenetics the Role of the piRNA Pathway in Mosquito Antiviral Matt Boehm, Jordi Bonaventura, Hank Jedema, Elliot Stein, Immunity Charles Bradberry, Mike Michaelides Adeline E. Williams, Ken E. Olson, Eric Calvo Graduate Student: Matt Boehm Graduate Student: Adeline E. Williams NIH Institute-Center: NIDA NIH Institute-Center: NIAID NIH Research Advisor: Dr. Mike Michaelides NIH Research Advisor: Dr. Eric Calvo University Research Advisor: Dr. Theresa Desrochers University Research Advisor: Dr. Ken E. Olson Graduate University: Brown University Graduate University: Colorado State University

95 100 Cembranoid as a Positive Allosteric Modulator of the α7 A Balancing Act: Engineering Hinge and Nicotinic Acetylcholine Receptor and Target for Transmembrane Domains of Chimeric Antigen Pain Treatment Receptors to Sensitize Tumor Killing while Mitigating Luis Rivera García, Vesna Eterovic, Yarimar Carrasquillo Toxicity Graduate Student: Luis Rivera García Justin M. Mirazee, Raul Cachau, Philippe Youkharibache, NIH Institute-Center: NCCIH Marie Pouzolles, Christopher Chien, Gregoire Altan-Bonnet, NIH Research Advisor: Dr. Yarimar Carrasquillo Naomi Taylor University Research Advisor: Dr. Vesna Eterovic Graduate Student: Justin M. Mirazee Graduate University: Universidad Central Del Caribe NIH Institute-Center: NCI NIH Research Advisor: Dr. Naomi Taylor 96 Graduate University: Johns Hopkins University Performance in Even a Simple Perceptual Task Depends on Mouse Secondary Visual Areas 101 Hannah C Goldbach, Bradley Akitake, Caitlin E. Leedy, Defining How Antibiotic Treatments Impact Host Mark H. Histed Anti-bacterial Immune Responses Graduate Student: Hannah C. Goldbach Julia Gross, David Weiss, Iain Fraser NIH Institute-Center: NIMH Graduate Student: Julia Gross NIH Research Advisor: Dr. Mark Histed NIH Institute-Center: NIAID Graduate University: Brown University NIH Research Advisor: Dr. Iain Fraser University Research Advisor: Dr. David Weiss Graduate University: Emory University

30 GRADUATE STUDENT RESEARCH SYMPOSIUM 2021

POSTERS

102 107 Examining the Molecular Mechanisms of RNA Astrocytic ALDH2 in the Brain is Central to the Control Polymerase Efficacy and its Role in the Pathogenesis of Alcohol Metabolism and Alcohol Intoxication and Evolution of Avian-Origin Influenza A Viruses Shiyun Jin, David M. Lovinger, Ye Zhang, Li Zhang Stephanie L. Williams, Ervin Fodor, Jeffery K. Taubenberger Graduate Student: Shiyun Jin Graduate Student: Stephanie L. Williams NIH Institute-Center: NIAAA NIH Institute-Center: NIAID NIH Research Advisor: Dr. Li Zhang and Dr. David M. Lovinger NIH Research Advisor: Dr. Jeffery K. Taubenberger University Research Advisor: Dr. Ye Zhang University Research Advisor: Prof. Ervin Fodor Graduate University: Anhui Medical University Graduate University: University of Oxford 108 103 Mechanisms of Presynaptic Modulation of Striatal Studying the Inductive Events of a Spontaneous Efferents by Gαi/o Coupled GPCRs Autoimmune Disease Giacomo Sitzia, Daniel Liput, Karina Possa Abrahao, Caleb E. Ng, Rachel R. Caspi Gian Marco Calandra, David M. Lovinger Graduate Student: Caleb E. Ng Graduate Student: Giacomo Sitzia NIH Institute-Center: NEI NIH Institute-Center: NIAAA NIH Research Advisor: Dr. Rachel R. Caspi NIH Research Advisor: Dr. David Lovinger Graduate University: University of Pennsylvania University Research Advisor: Dr. Karima Chergui Graduate University: Karolinska Institutet 104 Single Nucleus RNA-Sequencing Defines Unexpected 109 Diversity of Visceral Motor Neurons and Cholinergic Regulation and Coordination of Eukaryotic Interneurons in the Adult Mouse Spinal Cord RNase-PNK, a Disease-Associated RNA Processing Mor Alkaslasi, Zoe Piccus, Sangeetha Hareendran, Machine Required for Ribosome Production Hanna Silberberg, Li Chen, Yajun Zhang Jacob Gordon, Alan J. Warren, Robin E. Stanley Timothy Petros, Claire Le Pichon Graduate Student: Jacob Gordon Graduate Student: Mor R. Alkaslasi NIH Institute-Center: NIEHS NIH Institute-Center: NICHD NIH Research Advisor: Dr. Robin E. Stanley NIH Research Advisor: Dr. Claire Le Pichon University Research Advisor: Prof. Alan J. Warren Graduate University: Brown University Graduate University: University of Cambridge

105 110 Single Nucleus RNA-Sequencing Defines Unexpected The Functional Role of Chromatin Domains in Gene Diversity of Skeletal Motor Neurons in the Adult Mouse Expression Spinal Cord Faisal Almansour, Varun Sood, Dan Larson, Tom Misteli Zoe Piccus, Mor Alkaslasi, Sangeetha Hareendran, Graduate Student: Faisal Almansour Tim Petros, Hanna Silberberg, Li Chen, Yajun Zhang, NIH Institute-Center: NCI Claire Le Pichon NIH Research Advisor: Dr. Tom Misteli Graduate Student: Zoe E. Piccus University Research Advisor: Dr. Jessica Jones NIH Institute-Center: NICHD Graduate University: Georgetown University NIH Research Advisor: Dr. Claire Le Pichon Graduate University: Brown University 111 Investigating Oxaliplatin Resistance in Colorectal 106 Cancer (CRC) Using Genome-Scale CRISPR Screens Subcellular Segregation of Synaptic Long Term Heidi M. Wade, George Alyateem, Aaron A. Bickert, Dalen Depression in Hippocampus CA1 Chan, Crystal C. Lipsey, Robert W. Robey, Pedro J. Batista, Kevin M. Keary III, Zheng Li Michael M. Gottesman Graduate Student: Kevin M. Keary III Graduate Student: Heidi M. Wade NIH Institute-Center: NIMH NIH Institute-Center: NCI NIH Research Advisor: Dr. Zheng Li NIH Research Advisor: Dr. Michael M. Gottesman Graduate University: Brown University University Research Advisor: Dr. Wade Winkler Graduate University: University of Maryland, College Park

31 NATIONAL INSTITUTES OF HEALTH

POSTERS

112 117 Using Endometrial Organoids to Characterize Identification of Super-Enhancers Driving Chronic Molecular Changes in Uterine Glands from Neonatal Kidney Disease DES-Exposed Mice Jakub Jankowski, Julia Wilflingseder, Hye Kyung Lee, Tansy Gu, Alisa Suen, Wendy Jefferson, Carmen Williams Lothar Hennighausen Graduate Student: Tansy Gu Graduate Student: Jakub Jankowski NIH Institute-Center: NIEHS NIH Institute-Center: NIDDK NIH Research Advisor: Dr. Carmen Williams NIH Research Advisor: Dr. Lothar Hennighausen Graduate University: University of North Carolina, Chapel Hill University Research Advisor: Dr. Julia Wilflingseder Graduate University: University of 113 Veterinary Medicine, Vienna Grb2 nSH3 and cSH3 Domains Perform Similarly High Affinity Interactions with the Segments of SOS1 118 Proline-Rich Domain Characterizing Multimodal Phenotypes in Sex Tsung-Jen Liao, Hyunbum Jang, Ruth Nussinov, David Chromosome Aneuploidies Fushman Elizabeth Levitis, Ethan T. Whitman, Siyuan Liu, Erin Torres, Graduate Student: Tsung-Jen Liao Allysa Warling, Liv S. Clasen, Jonathan D. Blumenthal, NIH Institute-Center: NCI François M. Lalonde, Daniel Alexander, Armin Raznahan NIH Research Advisor: Dr. Ruth Nussinov Graduate Student: Elizabeth Levitis University Research Advisor: Dr. David Fushman NIH Institute-Center: NIMH Graduate University: University of Maryland, College Park NIH Research Advisor: Dr. Armin Raznahan University Research Advisor: Dr. Daniel Alexander 114 Graduate University: University College London The Local Dynamics of Basement Membrane Breaching During Cell Invasion 119 Shayan S. Nazari, Andrew D. Doyle, Kenneth M. Yamada The Dogs of Chernobyl: Genetic Effects of Low Dose Graduate Student: Shayan S. Nazari Ionizing Radiation in a Canine Model NIH Institute-Center: NIDCR Gabriella J. Spatola, Heidi G. Parker, Timothy A. Mousseau, NIH Research Advisor: Dr. Kenneth M. Yamada Elaine A. Ostrander Graduate University: University of North Carolina, Charlotte Graduate Student: Gabriella J. Spatola NIH Institute-Center: NHGRI 115 NIH Research Advisor: Dr. Elaine A. Ostrander Diversity and Evolution of Viroid-like RNA Agents University Research Advisor: Dr. Timothy A. Mousseau Benjamin D. Lee, Peter Simmonds, Eugene V. Koonin Graduate University: University of South Carolina Graduate Student: Benjamin D. Lee NIH Institute-Center: NLM 120 NIH Research Advisor: Dr. Eugene V. Koonin Elucidating Roles of p53 and Key Isoforms in the University Research Advisor: Prof. Peter Simmonds Tumor-Immune Microenvironment Graduate University: University of Oxford Neha Wali, Izumi Horikawa, Curtis C. Harris Graduate Student: Neha Wali 116 NIH Institute-Center: NCI Examination of Parkinson’s and Alzheimer’s Disease- NIH Research Advisor: Dr. Curtis C. Harris Related Genes in Lewy Body Dementia University Research Advisor: Prof. Xin Lu Marya S. Sabir, Ruth Chia, Ali Torkamani, Eric Topol, Adriano Graduate University: University of Oxford Chio, Owen Ross, J. Raphael Gibbs, Clifton L. Dalgard, Bryan J. Traynor, Sonja W. Scholz on behalf of the International LBD 121 Genomic Consortium Development of a Multivalent ChAdOx1-MVA Vaccine Graduate Student: Marya S. Sabir for the Treatment of Giloblastoma NIH Institute-Center: NINDS Emily E. Steffke, Nicola Sibson, Carol Leung, NIH Research Advisor: Dr. Sonja W. Scholz Benoit Van Den Eynde, Masaki Terabe University Research Advisor: Dr. Michele T.M. Hu Graduate Student: Emily E. Steffke Graduate University: University of Oxford NIH Institute-Center: NCI NIH Research Advisor: Dr. Masaki Terabe University Research Advisor: Dr. Carol Leung and Dr. Benoit Van Den Eynde Graduate University: University of Oxford

32 GRADUATE STUDENT RESEARCH SYMPOSIUM 2021

POSTERS

122 127 Numeric and Spatial Distributions of Neoantigen IDH Mutated Gliomas Promote Epileptogenesis via D-2- Quality as Predictors of Overall Tumor Immunogenicity hydroxyglutarate Dependent mTOR Hyperactivation Anagha Krishnan, Grégoire Altan-Bonnet, Martin Miller Armin Mortazavi, Islam Fayed, Muzna Bachani, Tyrone Graduate Student: Anagha Krishnan Dowdy, Joseph Steiner, Dragan Maric, Chun Zhang Yang, NIH Institute-Center: NCI Mioara Larion, Alexander Ksendzovsky, Kareem Zaghloul NIH Research Advisor: Dr. Grégoire Altan-Bonnet Graduate Student: Armin Mortazavi University Research Advisor: Dr. Martin Miller NIH Institute-Center: NINDS Graduate University: University of Cambridge NIH Research Advisor: Dr. Kareem Zaghloul Graduate University: Georgetown University School of 123 Medicine Activation-Induced Deaminase Targeting to the IgH Variable Region in Somatic Hypermutation 128 Stormy E. Ruiz, Robert W. Maul, Justin Heltzel, Central Oxytocin Reduces Anxiety- and Depression- Patricia Gearhart Like Behavior in Mice Graduate Student: Stormy E. Ruiz Khalin E. Nisbett, Marina Tereul, Michael E. Ragozzino, NIH Institute-Center: NIA Leandro F. Vendruscolo, George F. Koob NIH Research Advisor: Dr. Patricia Gearhart Graduate Student: Khalin E. Nisbett Graduate University: Johns Hopkins University School of NIH Institute-Center: NIDA Medicine NIH Research Advisor: Dr. George Koob Graduate University: University of Illinois, Chicago 124 Role of Protein Tyrosine Phosphatase 1B (PTP1B) 129 in Endothelial-Mesenchymal Transition (EndoMT) Distinguishing Functional Subpopulations of Retinal Promoted by Inflammation: Implications for SLE Neurons Driving Diverse Non-Image Forming Jorge Romo-Tena, Carmelo Carmona-Rivera, Luz P. Blanco, Behaviors Jose Esparza-Lopez, Maria de Jesus Ibarra-Sanchez, Kat Daly, Michael Thomsen, Bill Keenan, Samer Hattar Mariana J. Kaplan Graduate Student: Kat Daly Graduate Student: Jorge Romo-Tena NIH Institute-Center: NIMH NIH Institute-Center: NIAMS NIH Research Advisor: Dr. Samer Hattar NIH Research Advisor: Dr. Mariana J. Kaplan Graduate University: Johns Hopkins University University Research Advisor: Dr. Maria de Jesus Ibarra-Sanchez Graduate University: Universidad Nacional Autonoma de Mexico

125 Developing Biomarkers of TDP-43-Related Splicing Dysfunction in Frontotemporal Dementia Sahba Seddighi, Sarah Hill, Anna-Leigh Brown, Andy Qi, James Hawrot, Steve Coon, Len Petrucelli, Pietro Fratta, Michael Ward Graduate Student: Sahba Seddighi NIH Institute-Center: NINDS NIH Research Advisor: Dr. Michael Ward University Research Advisor: Dr. Cornelia van Duijn Graduate University: University of Oxford

126 Virally Mediated Synaptic Dysfunction in ALS Nicholas Pasternack, Ole Paulsen, Avindra Nath Graduate Student: Nicholas Pasternack NIH Institute-Center: NINDS NIH Research Advisor: Dr. Avindra Nath University Research Advisor: Prof. Ole Paulsen Graduate University: University of Cambridge

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