Curriculum Vitae

Geoffrey K. Isbister BSc MBBS FACEM MD

Formal Qualifications:

 Bachelor of Science (1987-1990) – Biophysics, Biochemistry and Physiology. University of NSW  Bachelor of Medicine, Bachelor of Surgery (1991-1994) – Honours I. University of NSW  Doctor of Medicine (2004) – University of Newcastle

Awards, Fellowships and Memberships

1. 2014: John Gilroy Potts Award, Australasian College for Emergency Medicine – best refereed paper contributing to emergency medicine in 2013. 2. 2014 Senior Braun Fellowship, University of Newcastle 3. 2014 (Inaugural) Fellow of the European Association of Poison Centres and Clinical Toxicologists 4. 2013 Australian Society of Clinical and Experimental Pharmacology and Toxicology – Achievement Award. 5. 2013 Vice-Chancellor’s Awards for Research Excellence, Faculty of Health, University of Newcastle. 6. 2013: Faculty of Health Research Staff Excellence, University of Newcastle. 7. 2012: John Gilroy Potts Award, Australasian College for Emergency Medicine – best refereed paper contributing to emergency medicine in 2011. 8. 2011: STARS Fellowship, University of Newcastle 9. 2011: Informa Health Care Award, Best Scientific Presentation, International Congress of the European Association of Poison Centres and Clinical Toxicology.

10. 2010: John Gilroy Potts Award, Australasian College for Emergency Medicine – best refereed paper contributing to emergency medicine in 2009.

11. 2010: IUTOX Early Toxicologist Award, XII International Congress of Toxicology

12. 2009: ASCEPT visiting lecturer to the British Toxicology Society 13. 2008: Informa Health Care Award, Best Scientific Presentation, International Congress of the European Association of Poison Centres and Clinical Toxicology. 14. 2007: Cosmos Bright Sparks Award: Top 10 young scientists in Australia 15. 2007: Medical Journal of Australia/Wyeth Research Award for 2006 16. 2005: Morson Taylor Research Award, Emergency Medicine Research Foundation 17. 2005: NSW Young Tall Poppy Award – Australian Institute of Political Science 18. 2004: Finalist, Eureka Skeptics Award, Australian Museum, Sydney 19. Fellowship Australasian College of Emergency Medicine (FACEM) awarded March 2002 20. 2002: Young Medical Researcher of the Year (Hunter Medical Research Institute) 21. 2002: Best presentation at the scientific meeting of the Australasian College of Emergency Medicine, 2002. 22. 2000: ASCEPT Hypertox prize 2000, best presentation in clinical toxicology at an ASCEPT conference 23. 1995: Greg Monaghan Award (Intern of the Year 1995) 24. 1994: Student Anaesthetics Award for a year 6 student – Liverpool Hospital 25. 1993: 2/5 Australian General Hospital Associations Prize for best performance in general practice/subspeciality term. 26. 1989: Australian Institute of Physics Prize – best performance in third year physics 27. 1988: School of Mathematics Prize: best performance, year 2 higher mathematics 28. 1988: Physics Staff Prize for Physics 2 – best performance in second year physics. 29. 1987: Physics Prize 1st year – best performance in first year physics.

Current Appointments  Professor, School of Medicine and Public Health, University of Newcastle, (2015-)  Senior Staff Specialist, Clinical Toxicology and Emergency Medicine, Calvary Mater Newcastle (2007-)  Honorary Associate Professor, Department of Pharmacology, Monash University, Melbourne (2007-)  VMO Clinical Toxicology, NSW Poison Information Centre, the Children’s Hospital at  Member, Drug Committee: The Children’s Hospital at Westmead, Sydney (2003-)  Visiting Medical Officer, Clinical Pharmacology, Childrens Hospital Westmead (2003-)  Member, Scientific Committee, Australasian College for Emergency Medicine (2003-)  Honorary Consultant and Clinical Toxicologist, Queensland Poison Information Centre, Royal Children’s Hospital and Health Service District (2002-)

Previous Appointments  Associate Professor, Discipline of Clinical Pharmacology, University of Newcastle, (2010-2014)  Research Consultant, School of Pharmacy, University of Queensland (April 2006-2010)  Conjoint Associate Professor, Discipline of Clinical Pharmacology, University of Newcastle, (2009)  Principal Research Fellow, Tropical Toxinology Unit, Menzies School of Health Research, Charles Darwin University (January 2009-Dec 2009)  Executive Editor and Original Research Section Editor, Emergency Medicine Australasia (2004 -2009)  Conjoint Senior Lecturer, Discipline of Clinical Pharmacology, University of Newcastle (2004-2009)  Senior Research Fellow, Menzies School of Health Research (2005-2008)  Staff Specialist, Clinical Toxicology and Emergency Medicine, Calvary Mater Hospital (2004-2007)  Acting Director, Hunter Area Toxicology Service, Newcastle Mater Hospital (Nov 2004 – May 2005)  Honorary Senior Lecturer, Department of Pharmacology, Monash University (2003-2007)  Honorary Consultant and Clinical Toxicologist NSW Poison Information Centre, The Children’s Hospital at Westmead, Sydney (Jan 2002 – Jun 2004)  Clinical Academic in Clinical Toxicology, Newcastle Mater Hospital (2002-2003)  Lecturer, Discipline of Clinical Pharmacology, University of Newcastle (2002 – 2003)  Newcastle Mater Misericordiae Hospital (Senior Registrar in Toxicology 2000 - 2001)  Royal Darwin Hospital (Emergency and Paediatric Registrar 1999 - 2000): including adult, paediatric and neonatal retrieval medicine.  Royal Prince Alfred Hospital (Emergency Registrar 1997-1999): including ICU/Anaesthetics  Liverpool Hospital (1995 – 1996): Intern and Resident, representative to the General Clinical Training Committee; Secretary, Liverpool Hospital RMO Association  Technical Officer, Biophysics Department , University of NSW (1989 – 1991)

Memberships  Australasian College of Emergency Medicine:  International Society of Toxinology (IST): o Member, Scientific Committee for the 14th International Congress on Animal, Plant and Microbial toxins, Adelaide 2003  Australasian Society of Clinical and Experimental Pharmacology and Toxicology (ASCEPT)  European Association of Poisons Centres and Clinical Toxicologists (EAPCCT) Conference Organisation  Scientific Committee, International Congress on Animal, Plant and Microbial Toxins, Oxford, 2015  Co-organiser (Scientific), Toxicology and Poisons Network Australasia, Annual Scientific Meetings, Newcastle, 2013 and 2014.  Local Organiser, Population Analysis Group of Australia and New Zealand 2009  Chair, Scientific Committee for the Australian College for Emergency Medicine Winter Symposium, Darwin, 2009  Chair, Scientific Committee for the Australian College for Emergency Medicine Winter Symposium, Newcastle, 2008.  Member, Scientific Committee for the 14th International Congress on Animal, Plant and Microbial toxins, Adelaide 2003 Invited Presentations 1. 18th Annual Scientific Meeting of Australasian College for Emergency Medicine, Hobart 2001: Invited speaker “Necrotic Arachnidism.” 2. North American Congress on Clinical Toxicology (NACCT) Meeting, Montreal, 2001 : ASCEPT symposium: “Data Collection in Clinical Toxinology” 3. NSW Rural Doctor’ Network Annual General Meeting; Conference December 2001 “Envenomation Update” 4. European Association of Poisons Centres and Clinical Toxicologists (EAPCCT) XXII International Congress, Portugal, 2002: Keynote Lecture: “Data collection in Clinical Toxinology: Debunking myths and developing diagnostic algorithms.” 5. Monash University, Department of Pharmacology, Research Meeting “Serotonin Syndrome . . . a misunderstood phenomena” September 2002 6. Rural Doctors Association of Victoria & South Australia Annual Conference 2002 October “Snake and Spider bite” 7. Australasian College for Emergency Medicine: Winter Symposium 2003, Melbourne: Invited speaker: “Australian spider bite: An update and approach to management” 8. 9th Southeast Asian-Western Pacific Regional Meeting of Pharmacologists in Korea in 2003: Invited symposium speaker: “Venom Research: Does the clinician have a role?” 9. North American Congress on Clinical Toxicology (NACCT) Meeting, Chicago, 2003: ASCEPT symposium: “Venomous fish stings” 10. 14th International Congress on Animal, Plant and Microbial toxins, Adelaide 2003: Invited speaker, short plenary session: “Spider mythology and data collection in clinical toxinology” 11. Hunter Rural Doctors Association Annual General Meeting, 2003: “Marine stings” 12. Undersea and Hyperbaric Medical Society Annual Scientific Meeting, Sydney, May 2004: Lunchtime seminar “A Skeptics View of Australian Marine Nasties” 13. Australasian College for Emergency Medicine Annual Scientific Meeting, Adelaide, 2004: Invited talk “Toxinology Update” 14. University of Queensland, School of Pharmacy, February 2005: “Serotonin Syndrome . . . a misunderstood phenomena” 15. Menzies School of Health Research, February 2005, “Venomous Myths in Medicine…forget what you read in the MJA” 16. Hunter New England Health, Critical Care Dinner for Nursing Education, March 2005 “Brown Snake: to retrieve or not to retrieve” 17. National Congress in Brazil, Florianopolis, March 2005: Plenary lecture and Mini-course: “Toxicologia Clínica Baseada em Evidências” 18. Plenary Speaker, “Medically Important Spiderbite in Australasia” and “Tetrodotoxin Poisoning: Advances in Analytical and Neurophysiological Testing”; Workshop on Natural Toxins, Taipei Veterans General Hospital, Clinical Toxicology Conference, Taiwan, June 2005 19. Australasian College for Emergency Medicine: Winter Symposium 2005, Queenstown, New Zealand: Invited speaker: “White tailed spider bites” 20. Emergency Medicine Update, School of Rural Health, UNSW, Wagga Wagga, September 2005: “Reptiles and Arachnids: a cutting edge approach to a biting problem”. 21. Western Australian Faculty Meeting, Emergency Medicine, April 2006: “Estimation of Brown Snake Antivenom Dose in Envenomed Patients and with in vitro studies” 22. NSW branch, Society of Hospital Pharmacists of Australia, Seminar, May 2006: “Serotonin Syndrome . . . a misunderstood phenomena” 23. AIMS Tropical Meeting Townsville: Estimation of Brown Snake Antivenom Dose in Envenomed Patients and with in vitro studies. June 2006 24. Asia-Pacific Association of Medical Toxicology, Scientific Congress, Sri Lanka, August 2006; Two invited talks: “Estimating the effect of charcoal in overdose: pharmacokinetic- pharmacodynamic modeling and empirical studies in a Bayesian World” and “Tailoring snake antivenom: Estimation of antivenom dose and determination of clinically applicable end-points for treatment” 25. AIMS Queensland Meeting: Invited Speaker: “Snakes, Spiders, Jellyfish…Biting problems for the laboratory”; September 2006. 26. North American Congress on Clinical Toxicology (NACCT) Meeting, San Francisco, 2006 : Clinical Toxinology MiniCourse CME; October 2006 27. Haematology Society Australia and New Zealand/Australasian Society of Haemostasis and Thrombosis, Hobart October 2006: “Brown Snake Coagulopathy: antivenom efficacy and clinically applicable end-points for treatment” 28. AMUQ Annual Scientific Conference, Quebec City, Canada October 2006; Three invited talks: “Clinical toxicology research and Drug Modelling.”,”Ouch, i just got bitten!” and “Carbon monoxyde. Review of the evidence for HBO.” 29. Venom Week conference, Tucson, Arizona September, 2007; Two Invited talks - “Elapids and Coagulopathy” and “Australian Venomous Creatures and Chair of a Working Group on Serum Markers 30. 24th Annual Scientific Meeting of Australasian College for Emergency Medicine, Gold Coast, November 2007: Symposium of Toxinology. 31. 6th Congress of the Asia Pacific Association of Medical Toxicology, Bangkok December 2007, “Marine Toxicity”. 32. ISLH 2008, XXIst International Symposium on Technological Innovations in Laboratory Hematology, April 2008, Sydney: “The Role Of Coagulation Testing In Snake Envenoming” 33. Australasian College for Emergency Medicine: Winter Symposium 2008, Newcastle: Invited speaker: “Antivenom Update” 34. Haematology Society of Australia and New Zealand Annual Scientific Meeting: Snakebite coagulopathy: Antivenom, FFP or nothing at all, Perth, 2008 35. Global Issues in Clinical Toxinology, November 2008, Melbourne: Invited Lecture 36. British Toxicology Society, United Kingdom, 2009; ASCEPT Plenary Lecture: "Snake bite: insights in toxins and human behaviour" 37. Australian Red Cross Blood Service – iTransfuse 2009: Invited Speaker: “Snakebite coagulopathy: insights into the coagulation pathway and fresh frozen plasma”. Sydney 2009 38. European Association of Poisons Centres and Clinical Toxicologists (EAPCCT) XXIX International Congress, Sweden, 2009: Invited Lecture: “Marine Toxinology” 39. Australasian College for Emergency Medicine: Winter Symposium 2009, Darwin: Plenary : “Snake bite coagulopathy: can we rationalise snake antivenom in Australia” 40. International Society of Thrombosis and Haemostasis, Boston, 2009; Symposium Lecture: “Snake bite coagulopathy” 41. Hunter Postgraduate Medical Institute, “The Suspected Spiderbite or Insect Sting”, Newcastle, August 2009 42. 11th Congress of Therapeutic Drug Monitoring & Clinical Toxicology, Symposium: New insight into the inter-individual variability of pharmaco/toxicokinetics, Montreal, 2009 43. Australasian Society of Clinical and Experimental Pharmacology and Toxicology (ASCEPT) Annual Scientific Meeting, Sydney, 2009: “Drug-induced QT prolongation and TdP: How do we make a risk assessment in the individual patient?” 44. European Association of Poisons Centres and Clinical Toxicologists (EAPCCT) XXX International Congress, France, 2010: Invited Lecture: “Toxicology and the ECG” 45. 27th CINP Congress Meeting, Hong Kong, 2010. Pathophysiology of serotonin toxicity: A tale of rodents, receptors and remedies. 46. Annual Newcastle Hospitals Congress 2010, Invited Talk: “Snake Venom Coagulopathy” 47. ANZ Paediatric Haematology and Oncology Group, Sydney, 2010: “Snakebite and coagulopathy” 48. North American Congress on Clinical Toxicology (NACCT) Meeting, Denver, 2010 : APAMT symposium: “Sri Lankan Snakebite” 49. AACB AIMS Combined Scientific Meeting, Perth 2010: Invited lecture: “The Australian Snakebite Project” 50. Australasian Society of Clinical and Experimental Pharmacology and Toxicology (ASCEPT) Annual Scientific Meeting, Melbourne, 2010: “Developing a Rational Approach to Antivenom therapy” 51. European Association of Poisons Centres and Clinical Toxicologists (EAPCCT) XXXI International Congress, Croatia, 2011: Invited Lecture: “Snake envenomation-related coagulopathy and Fab immunotherapy” 52. International Congress on Animal, Plant and Microbial toxins, Vladivostok 2011: Invited speaker: “Understanding the Effectiveness of Antivenom Therapy”. 53. Australasian College for Emergency Medicine: Annual Scientific Meeting 2011, Sydney: Invited speaker: “Toxinology Update” 54. European Association of Poisons Centres and Clinical Toxicologists (EAPCCT) XXXII International Congress, London, 2012: Invited Lecture: “Spider Bite” 55. Australasian College for Emergency Medicine: Annual Scientific Meeting 2012, Hobart: Invited speaker: “Randomised controlled trial of FFP in snakebite coagulopathy” 56. Congress of the Asia Pacific Association of Medical Toxicology, Hong Kong, November 2012, “Randomised controlled trial of FFP in snakebite coagulopathy”. 57. Social Media and Critical Care Conference, Sydney, 2013: Invited Speaker: “Does Antivenom Work?” 58. ACEM - Evidence in Review Emergency Medicine, Terrigal, March 2013, Invited Talk: “Bites and Stings: What’s the new evidence”. 59. Toxicology and Poison Network Association, 2nd Scientific Meeting, Newcastle 2013, “A Novel NAC Regime”. 60. Emergency Care Institute, ED Leadership Forum, Sydney May 2013. “Envenoming: Where’s the toxicologist, antivenom and helicopter?” 61. Annual Newcastle Hospitals Congress August 2013, Invited Talk: “” 62. Annual Academic Sessions of the Ceylon College of Physicians, jointly with the Royal College of Physicians (London); Colombo, September 2013 “Snake Envenoming” 63. Emergency Medicine Trainee Conference Day: Masterclass 2013, “Envenomation- the cutting edge”. 64. Australasian College for Emergency Medicine Annual Scientific Meeting, Adelaide 2013; two invited talks: “Point of treatment for snakebite: helicopters, antivenom and point of care testing” and “Marine envenoming: all the same nasties or different nasties.” 65. NSW Rural Doctor Network Conference, Sydney December 2013. “Snake envenoming” 66. 15th International Conference of Emergency Medicine 2014, Hong Kong, “Snake envenoming: working toward a unified approach to treatment worldwide” AND ” QT and the ECG: Assessing cardiac toxicity in overdose patients” 67. One Health Conference, Peradeniya, Sri Lanka 2014. ““Developing global strategies for the diagnosis and treatment of snake bite”. 68. Haematology Society of Australia and New Zealand Annual Scientific Meeting, Perth, 2014: Snakebite coagulopathy. Peer Review Grant application review NHMRC Career Development Fellowship Panel (2013-2015) NHMRC Project Grant Panel 2009 NHMRC Project Grant External Assessor (2002-) Manuscript review Current reviewer or reviewed for: Lancet, New England Journal of Medicine, PLOS Medicine, Quarterly Journal of Medicine, Medical Journal of Australia, Clinical Pharmacology and Therapeutics, Critical Care Medicine, British Journal of Haematology, Toxicon, British Journal of Clinical Pharmacology, Clinical Toxicology, Lancet Neurology, Intensive Care Medicine, Emergency Medicine Journal, Annals of Pharmacotherapy, Clinical and Experimental Pharmacology and Physiology, Transactions of the Royal Society of Tropical Medicine and Hygiene, American Journal of Tropical Medicine and Hygiene, Biological Psychiatry, Journal of Arachnology Editorial responsibilities 1. Guest Editor PLoS Neglected Tropical Diseases, 2013- 2. International Editorial Board Member and Reviews Editor, British Journal of Clinical Pharmacology 2010+ 3. Editorial Board Member, Journal of Venom Research 2010+ 4. Editorial Board Member, Toxicon 2006+ 5. Executive Editor, Original Research and Toxicology Editor: Emergency Medicine Australasia 2004 - 2009 6. Guest Editor: Symposium on clinical toxinology and antivenom usage; Journal of Toxicology: Clinical Toxicology 2003. 7. Editorial Board: Journal of Occupational Medicine and Toxicology. 2004+ Research grant support Current  NHMRC Senior Research Fellowship (B). “Multicentre studies of interventions in clinical toxicology and envenoming, including antivenoms, antidotes and decontamination” Isbister G. $739,515  NHMRC Program Grant: “An integrated research program in human toxicology to ensure rapid translation of results into practice and regulation.” Buckley NA, Isbister GK, Dawson A, Roberts M. 2014-2018. $6,846,800.00 (UNSW)  NHMRC Project Grant: “Neurotoxicity after acute anticholinesterase pesticide poisoning and envenomation.” Buckley NA, Senanayake N, Isbister G, Dawson A, Karalliedde L, de Silva J. 2012-2015. $970,970. (UNSW)  NHMRC Project Grant “Snakebite First Aid” van Helden D, Isbister GK. 2012-2013. $192,450 (University of Newcastle).  Hunter Medical Research Institute “First Aid for cytotoxic snakebite” Van Helden D, Isbister GK. 2012 $25,000  NSW Health Drug and Alcohol Research Grants Program “The DORM II study: a post-implementation safety study of droperidol for acute behavioural disturbance in the emergency department” Isbister GK, Calver L, Miller M. 2011-2012 $18,190  University of Newcastle “Multicentre studies in clinical toxinology, including interventions for snake and spider envenoming with antivenom and adjunct treatments.” Isbister GK. 2011. $50,000  NHMRC Project Grant “A randomised controlled trial of antivenom and corticosteroids for red-bellied black snake envenoming.” Isbister GK, Buckley NA. 2011-2014. $445,576 (University of Newcastle).  NHMRC Project Grant “Biomarkers of acute renal toxicity in humans.” Buckley N, Endre, Z, Dawson A, Sheriff R, Isbister GK, Roberts M. 2011-2013. $1,044,710 (University of NSW).  University of Otago Research Grant. Evaluation of the kinetics of blood clotting for assessing enoxaparin activity. Duffull, Isbister, Faed. $15,000; 2010 Past  NHMRC Clinical Career Development Award “Multicentre studies of interventions in clinical toxicology and envenoming, including antivenoms and decontamination” 2010 – 2013; $417,000 (University of Newcastle)  NHMRC Project Grant “Does Fresh Frozen Plasma in Russells viper bite coagulopathy reduce the dose and duration of antivenom therapy?” Isbister GK, De Silva, HJ, Buckley N, Dawson A, Lalloo D. 2010-2012. $600,000 (University of Newcastle).  NHMRC Project Grant “Randomised controlled trial of intravenous antivenom versus placebo in the treatment of redback spider bite” Isbister GK, Brown SGA. 2009-2011. $439,000 (Menzies School of Health Research).  NHMRC Project Grant “A randomised controlled trial of factor replacement therapy in snake bite coagulopathy.” Isbister GK, Brown SGA, Buckley NA, Seldon M. 2008- 2010. $689,500 (Menzies School of Health Research).  NHMRC Clinical Career Development Award “Prospective evaluation of terrestrial and marine envenoming in humans: clinical effects, predictors of severity, toxicokinetics and potential treatments.” 2005 – 2009; $486,250.00 (Menzies School of Health Research)  NHMRC Project Grant Molecular toxinology of Australian Box jellyfish venoms. Hodgson WC, Isbister GK, Nicholson G, Seymour J. 2007-2009. $271,750 (Monash University)  NSW Health “A randomised controlled trial of intramuscular droperidol for rapid sedation of aggressive and agitated psychostimulant-associated delirium” Isbister GK Downes M, Sadler C. 2007-2008 $84,015  Food Allergy & Anaphylaxis Network (FAAN) Mediators in Anaphylaxis. Brown SGA, Isbister GK, Holdgate A. 2007-2008 $271,918USD  Morson Taylor Research Award 2005, Emergency Medicine Research Foundation Pty Ltd “A Randomised Controlled Trial of Hot Water (45°C) Immersion versus Ice Packs for Chironex fleckeri Stings. $9722.50  Associate Investigator: Sibbritt et al 2002-2004 $200,000 “Evaluation of the Perfecting Healthcare Delivery (PHD) Project. Hunter Area Health Service.  Margaret Mitchell Grant, Newcastle Mater Hospital, “A randomised controlled trial of warm water versus ice packs for acute treatment of blue bottle (Physalia spp.) stings” 2004 – 2005, $9650.56 Publications A. Refereed Journal Articles A1. Isbister GK, Whelan PI. Envenomation by the billygoat plum stinging caterpillar (Thosea penthima). Med.J.Aust. 2000; 173:654-655. A2. Isbister GK, Churchill TB, Hirst DB, Gray MR, Currie BJ. Clinical effects in bites from formally identified spiders in tropical Northern Territory. Med.J.Aust. 2001; 174:79-82. A3. Isbister GK, Bucens IK, Whyte IM. Paracetamol overdose in a preterm neonate. Archives of Disease in Childhood Fetal & Neonatal Edition, 85(1):F70-2, 2001 July A4. Isbister GK Venomous fish stings Am J Emerg Med Nov 2001 19(7);561-5 A5. Isbister GK, Dawson A, Whyte IM. Two cases of bites by the black-bellied swamp snake (Hemiaspis signata)” Toxicon. 2002 Mar; 40(3):317-19 A6. Isbister GK, Prior F, Foy A. “Citalopram-Induced Bradycardia and Presyncope” Ann Pharm 2001 Dec 35(12): 1552-5 A7. O’Reilly GM, Isbister GK, Lawrie PM, Treston G, Currie BJ. “Prospective study of jellyfish stings from tropical Australia, including the major box jellyfish Chironex fleckeri” Med.J.Aust. 2001; 175:652-5 A8. Isbister GK, Oakley P, Whyte IM, Dawson A. “Treatment of anticholinergic induced ileus with neostigmine” Ann Emerg Med; 2001 38:689-693 A9. Balit C, Ptolemy H, Geary MJ, Russell RC, Isbister GK. A caterpillar dermatitis outbreak following contact with the hairs of the Mistletoe Browntail moth (Euproctis edwardsi) Med J Aust 2001; 175:641-3 A10. Balit CR, Isbister GK, Peat J, Dawson AH, Whyte IM. Paracetamol recall: a natural experiment influencing analgesic poisoning. Med J Aust.2000;176:162-165 A11. Isbister GK. Data collection in clinical toxinology: debunking myths and developing diagnostic algorithms. J Toxicol Clin Toxicol 2002 40(3): 231-237 A12. Isbister GK. “Delayed asystolic cardiac arrest following diltiazem overdose; resuscitation with high dose intravenous calcium” Emerg Med J 2002;19:355-357 A13. Isbister GK. Acute allergic reaction following contact with a spider. Toxicon 2002; 40(10):25-27 A14. Eddleston M, Karalliedde L, Buckley N, Fernando R, Hutchinson G, Isbister G et al. Pesticide poisoning in the developing world--a minimum pesticides list. Lancet 2002; 360:1163-67 A15. Isbister GK, Gray MR. A prospective study of 750 definite spider bites with expert spider identification. QJM 2002; 95(11): 723-31 A16. Isbister GK. Failure of intramuscular antivenom in redback spider envenoming. Emerg. Med 2002; 14:436-439 A17. Isbister GK, Hirst D. Injuries from spider spines, not spider bites. Vet Hum Toxicol. 2002 Dec;44(6):339-42. A18. Isbister GK, Son J, Wang F, Maclean CJ, Lin CS, Ujma J, Balit CR, Smith B, Milder DG, Kiernan MC. Puffer fish poisoning: A potentially life-threatening condition. Med J Aust. 2002 Dec 2 16;177(11/12):650-653 A19. Balit CR, Lynch CN, Isbister GK. Bupropion Poisoning. Med. J. Aust 2003 Jan 20;178(2):61-63 A20. Isbister GK, Seymour JE, Gray MG, Raven RJ. Bites by spiders of the family theraphosidae in humans and canines. Toxicon 2003; 41(4):519-524 A21. Caldicott DGE, Isbister J, Das R, Isbister GK. Medical Activism, Refugees, and Australia (the land of the ‘fair go’). Emergency Medicine 2003;15:176-182 A22. Isbister GK, Currie BJ. Suspected snakebite: A one year prospective study of emergency department presentations. Emerg. Med 2003;15:160-169 A23. Ramasamy S, Isbister GK, Seymour JS, Hodgson WC. The in vitro effects of two chirodropid (Chironex fleckeri and Chiropsalmus sp.) venoms: efficacy of box jellyfish antivenom. Toxicon 2003;41(6):703-711 A24. Isbister GK, Balit CR, Dawson AH, Whyte IM. Valproate Poisoning: a comparative cohort study of self poisonings. Br J Clin Pharm 2003;55:398-404 A25. Isbister GK, Hackett LP. Nefazodone poisoning: toxicokinetics and toxicodynamics using continuous data collection. J of Toxicol Clin Toxicol 2003;41(2):167-173 A26. Isbister GK, Volschenk ES, Balit CR, Harvey MS. Australian scorpion stings: a prospective study of definite stings. Toxicon 2003;41(7):877-883 A27. Isbister GK, Gray MR. Latrodectism: a prospective cohort study of bites by formally identified red back spiders. Med J Aust. 2003 Jul 21;179(2):88-91 A28. Isbister GK, Dawson AH, Whyte IM. Feasibility of prehospital treatment with activated charcoal: Who could we treat, who should we treat? Emerg Med J. 2003 Jul;20(4):375-8. A29. Isbister GK, Hirst DH. A prospective study of definite bites by spiders of the family Sparassidae (Huntsmen spiders) with identification to species level. Toxicon 2003;42:163-71. A30. Isbister GK, Oakley P, Dawson AH, Whyte IM. Presumed Angels Trumpet (Brugmansia spp.) poisoning: clinical effects and epidemiology. Emerg. Med 2002; 15:376-382. A31. Isbister GK, Gray MR. White-tail spider-bite: A prospective study of 130 definite bites by Lampona species. Med J Aust 2003 Aug 18;179(4):199-202. A32. Dunkley EJC, Isbister GK, Sibbritt D, Dawson AH, Whyte IM. Hunter Serotonin Toxicity Criteria: a simple and accurate diagnostic decision rule for serotonin toxicity. QJM 2003;96:635-642 A33. Isbister GK, Balit CR. Bupropion overdose: QTc prolongation and its clinical significant. Ann Pharmacother. 2003 Jul 21;179(2):88-91. A34. Isbister GK. Acute conjunctival inflammation following contact with squashed spider contents. Am J Ophtalmol. 2003;136(3):563-4 A35. Isbister GK, Hackett LP, Dawson AH, Whyte IM, Smith AJ. Moclobemide poisoning: toxicokinetics and occurrence of serotonin toxicity, Br J Clin Pharm 2003;56(4):441-450. A36. Jaiswal S, Coombs RC, Isbister GK. Paroxetine withdrawal in a neonate with historical and laboratory confirmation. Eur J Ped 2003;162(10):723-4 A37. Balit CR, Geary MJ, Russell RC, Isbister GK. Prospective study of definite caterpillar exposures. Toxicon 2003;42(6):657-662. A38. Balit CR, Isbister GK, Buckley NA. Randomised controlled trial of topical aspirin in the treatment of bee and wasp stings. J Toxicol Clin Toxicol 2003;41(6):801-808. A39. Isbister GK, Gray MR. Effects of envenoming by comb-footed spiders of the genera Steatoda and Achaearanea (family Theridiidae: Araneae) in Australia. J Toxicol Clin Toxicol 2003;41(6):809-819. A40. Balit CR, Isbister GK, Whyte IM. Quetiapine poisoning: a case series. Ann Emerg Med 2003; 42(6):751-758. A41. Isbister GK, Hackett LP, Whyte IM. Intentional Warfarin Overdose. Ther Drug Monit. 2003 Dec;25(6):715-22 A42. Isbister GK, Warner G. Acute myocardial injury caused by Sydney funnel-web spider (Atrax robustus) envenoming. Anaesthesia and Intensive Care 2003;31(6):672-674 A43. Isbister GK, Downes F, Sibbritt D, Dawson AH, Whyte IM. Aspiration pneumonitis in an overdose population: frequency, predictors and outcomes. Crit Care Med 2004;32(1):88-93 A44. Isbister GK, Whyte IM. Suspected White-tail spider bite and Necrotic Ulcers. Intern Med J 2004 Jan;34(1-2):38-44 A45. Isbister GK, Gray MR. Bites by Australian Mygalomorph Spiders (Araneae, Mygalomorphae), including Funnel-web Spiders (Atracinae) and Mouse Spiders (Actinopodidae: Missulena spp). Toxicon 2004;43(2):133-140 A46. Balit CR, Geary MJ, Russell RC, Isbister GK. Clinical effects of exposure to the white- stemmed gum moth (Chelepteryx collesi). Emerg Med Aust 2004;16(1):74-81 A47. Isbister GK. Mouse spider bites (Missulena spp.) and their medical importance: a systematic review. Med J Aust 2004; 180(5):225-7 A48. Isbister GK, Sibbritt D. Developing a decision tree algorithm for the diagnosis of suspected spider bites. Emerg Med Aust 2004;16(2):161-166 A49. Balit CR, Harvey MS, Waldock, JM, Isbister GK. Prospective study of centipede bites in Australia. J Toxicol Clin Toxicol 2004;42(1):41-48. A50. Ramasamy S, Isbister GK, Seymour JS, Hodgson WC. The in vivo cardiovascular effects of box jellyfish Chironex fleckeri venom in rats: efficacy of pre-treatment with antivenom, verapamil and magnesium sulphate. Toxicon 2004;43(6):685-690 A51. Isbister GK, Gray MR. Black house spiders are unlikely culprits in necrotic arachnidism: a prospective study. Intern Med J 2004 May;34(5):287-289 A52. Isbister GK, Framenau VW. Australian wolf spider bites (Lycosidae): clinical effects and influence of species on bite circumstances. J Toxicol Clin Toxicol 2004;42(2):153-161. A53. Isbister GK, O’Regan L, Sibbritt D, Whyte IM. Alprazolam is relatively more toxic than other benzodiazepines in overdose. Br J Clin Pharm 2004;58(1):88-95 A54. Isbister GK. A prospective cohort study of definite spider bites in Australian children. J Paed Child Health 2004;40:360-364 A55. Isbister GK, Bowe SJ, Dawson A, Whyte IM. Relative toxicity of selective serotonin reuptake inhibitors (SSRIs) in overdose. J Toxicol Clin Toxicol 2004;42(3):277-285. A56. Isbister GK, Dawson AH, Whyte IM. Arsenic trioxide poisoning: a description of two acute overdoses. Hum Exp Toxicol 2004;23(7):359-364 A57. Isbister GK, Volschenk ES, Seymour JE. Scorpion Stings in Australian: five definite stings and a review. Intern Med J. 2004 Jul;34(7):427-30. A58. Isbister GK. Necrotic arachnidism: the mythology of a modern plague. Lancet 2004; 364:549-553 A59. O’Leary MA, Schneider JJ, Isbister GK. Use of high performance liquid chromatography to measure tetrodotoxin in serum and urine of poisoned patients. Toxicon 2004;44(5):549-553 A60. Ramasamy S, Isbister GK, Hodgson WC. The efficacy of two antivenoms against the in vitro myotoxic effects of black snake (Pseudechis) venoms in the chick biventer cervicis nerve- muscle preparation Toxicon. 2004 Dec 15;44(8):837-45. A61. Vetter RS, Isbister GK. Do hobo spider bites cause dermonecrotic injuries? Ann Emerg Med 2004 Dec;44(6):605-7 A62. Ramasamy S, Isbister GK, Seymour JS, Hodgson WC. The in vivo cardiovascular effects of the Irukandji jellyfish (Carukia barnesi) nematocyst venom and a tentacle extract in rats. Toxicology Letters 2005; 155(1):135-141 A63. Ramasamy S, Isbister GK, Seymour JS, Hodgson WC. Pharmacologically distinct cardiovascular effects of box jellyfish (Chironex fleckeri) venom and a tentacle-only extract in rats. Toxicology Letters 2005; 155(2):219-226 A64. Ramasamy S, Isbister GK, Seymour JS, Hodgson WC. The in vivo cardiovascular effects of an Australasian box jellyfish (Chiropsalmus sp.) venom in rats. Toxicon. 2005;1;45(3):321-7 A65. Kiernan MC, Isbister GK, Lin CY, Burke D, Bostock H. Acute Tetrodotoxin induced Neurotoxicity Following Ingestion Of Puffer Fish. Ann Neurol. 2005 Mar;57(3):339-48 A66. Juurlink DN, Buckley NA, Isbister GK, Bennett M, Stanbrook MB, McGuigan MA. Hyperbaric oxygen for carbon monoxide poisoning. Cochrane Database Syst Rev. 2005;(1) A67. Isbister GK, Gray MR, Balit CR, Raven RJ, Stokes B, Porges K, Tankel A, Turner E, White J, Fisher MM. Funnel-web spider bite: a systematic review of recorded clinical cases. Med J Aust 2005; 182(8):407-412. A68. Downes MA, Whyte IM, Isbister GK. QTc abnormalities in deliberate self poisoning with moclobemide. Int Med J 2005; 35:388-391

A69. Kuruppu S, Isbister GK, Hodgson WC. Phospholipase A2 dependent effects of the venom from the New Guinean small-eyed snake Micropechis ikaheka. Muscle Nerve.2005;32:81-7. A70. Buckley NA, Isbister GK, Stokes B, Juurlink DN. Hyperbaric oxygen for carbon monoxide poisoning: A systematic review and critical analysis of the evidence. Toxicol Rev. 2005;24(2):75-92. A71. Isbister GK, Hooper J. Clinical effects of stings by sponges of the genus Tedania and a review of sponge stings worldwide. Toxicon; 2005 Dec 1;46(7):782-5 A72. Isbister GK, Balit CR, Kilham HA. Antipsychotic poisoning in young children: a systematic review. Drug Saf. 2005;28(11):1029-1044 A73. Friberg LE, Isbister GK, Hackett LP, Duffull SB. The Population Pharmacokinetics of Citalopram after Deliberate Self-Poisoning: a Bayesian approach. J Pharmacokinet Pharmacodyn. 2005 Aug;32(3-4):571-605 A74. Leung N, Whyte I, Isbister GK. Baclofen overdose: defining the spectrum of toxicity. Emerg. Med. Australas 2006;18(1):77-82. A75. Friberg LE, Isbister GK, Duffull SB. Pharmacokinetic Pharmacodynamic Modelling of QT Interval Prolongation following Citalopram Overdoses. Br J Clin Pharm 2006;61(2):177-90 A76. Isbister GK, Hooper MR, Dowsett R, Maw G, Murray L, White J. Collett’s Snake (Pseudechis colletti) envenoming in snake handlers. QJM. 2006 2006 Feb;99(2):109-15. A77. Sibbritt D, Isbister GK, Walker R. Emergency department performance indicators that encompass the patient journey. Qual Manag in Health Care. 2006 January/March;15(1)27-38 A78. Isbister GK, Murray L, John S, Hackett LP, Haider T, O-Mullane P, Gosselin F, Daly F. Amisulpride deliberate self-poisoning causing severe cardiac toxicity including QT prolongation and Torsades de Pointes. Med J Aust. 2006 Apr 3;184(7):354-6. A79. Loten C, Stokes B, Worsely D, Seymour JE, Jiang S, Isbister GK. A Randomized Controlled Trial of Hot Water (45˚C) Immersion versus Ice Packs for pain relief in Physalia stings. Med J Aust. 2006 Apr 3;184(7):329-33 A80. Vetter RS, Isbister GK, Bush SP, Boutin LJ. Verified Bites By Yellow Sac Spiders (Genus Cheiracanthium) In The United States And Australia: Where Is The Necrosis? Am J Trop Med 2006 Jun;74(6):1043-8. A81. Vetter RS, Isbister GK. Verified bites by the woodlouse spider, Dysdera crocata. Toxicon 2006 Jun 1;47(7):826-9 A82. Balit CR, Lynch AM, Gilmore SP, Murray L, Isbister GK. Lignocaine and chlorhexidine toxicity in children resulting from mouth paint ingestion: a bottling problem. J Paed Child Health. Jun 2006;42(6):350-53 A83. Isbister GK, Friberg LE, Duffull SB. Application of pharmacokinetic-pharmacodynamic modelling in management of QT abnormalities after citalopram overdose. Intensive Care Med 2006 Jul;32(7):1060-5 A84. O’Leary MA, Isbister GK, Scheider JJ, Brown SGA, Currie BJ. Enzyme Immunoassays in Brown Snake (Pseudonaja spp.) envenoming: detecting venom, antivenom and venom- antivenom complexes. Toxicon 2006 Jul;48(1):4-11. A85. Isbister GK, O'leary MA, Schneider JJ, Brown SG, Currie BJ; on behalf of the ASP Investigators. Efficacy of antivenom against the procoagulant effect of Australian brown snake (Pseudonaja sp.) venom: In vivo and in vitro studies. Toxicon 2007 Jan;49(1):57-67. A86. Winter KL, Fernando R, Ramasamy S, Seymour JE, Isbister GK, Hodgson WC. The in vitro cardiovascular effects of two chirodropid (Chironex fleckeri and Chiropsella bronzie) venoms. Toxicol Lett. 2007 Jan 10;168(1):13-20. A87. Isbister GK, Williams V, Brown SGA, White J, Currie BJ. Clinically applicable laboratory end-points for treating snakebite coagulopathy. Pathology 2006;38(6):568–572 A88. Jansen M, McLeod M, White J, Isbister GK. Spotted black snake (Pseudechis guttatus) envenoming. Med J Aust 2007; 186 (1): 41-42 A89. Winter KL, Isbister GK, Seymour JE, Hodgson WC. An in vivo examination of the stability of venom from the Australian box jellyfish Chironex fleckeri. Toxicon. 2007;49(6):804-9. A90. Morgan M, Hackett LP, Isbister GK. Olanzapine overdose: a series of analytically confirmed cases. Int Clin Psychopharmacol. 2007 May;22(3):183-6. A91. Isbister GK, Friberg LE, Hackett LP, Duffull SB. Pharmacokinetics of quetiapine in overdose and the effect of activated charcoal. Clin Pharm Ther 2007 Jun;81(6):821-7.

A92. O’Leary MA, Schneider JJ, Krishnan BP, Lavis C, McKendry A, Ong LK, Isbister GK. Cross neutralisation of Australian brown and tiger snake venoms with commercial antivenoms: cross-reactivity or antivenom mixtures? Toxicon. 2007 Aug;50(2):206-13. A93. Isbister GK, Little M, Cull G, McCoubrie D, Lawton P, Ferenc SF, Kennedy J, Trethewy C, Luxton G, Brown SGA, Currie BJ. Thrombotic microangiopathy from Australian Brown Snake (Pseudonaja) Envenoming Intern Med J. 2007 Aug;37(8):523-8. A94. Isbister GK, Friberg LE, Stokes B, Buckley NA, Lee C, Gunja N, Brown SGA, MacDonald E, Graudins A, Holdgate A, Duffull SB. Activated charcoal decreases the risk of QT prolongation after citalopram overdose. Ann Emerg Med. 2007;50(5):593-600, 600.e1-46. A95. Balit CR, Gilmore SP, Isbister GK. Unintentional paediatric ingestions of angiotensin converting enzyme inhibitors and angiotensin II receptor antagonists. J Paed Child Health 2007 Oct;43(10):686-688 A96. Chan A, Isbister GK, Kirkpatrick CMJ, Duffull SB. Drug-induced QT prolongation and Torsades de Pointes: evaluation of a QT nomogram. QJM. 2007 Oct;100(10):609-15. A97. Brown SGA, Isbister GK, Stokes B. Route of administration of redback spider bite antivenom : Determining clinician beliefs to facilitate Bayesian analysis of a clinical trial. Emerg Med Australas. 2007 Oct;19(5):458-63. A98. Ramjan K, Elliot E, Isbister GK. "Red as a beet and blind as a bat" Anticholinergic delirium in adolescents: lessons for the paediatrician. . J Paediatr Child Health. 2007;43(11):779-80 A99. Isbister GK. The safety of intravenous administration of redback spider antivenom. Intern Med J. 2007 Dec;37(12):820-2.

A100. Isbister GK, O’Leary MA, Miller M, Brown SGA, Ramasamy S, James R, Schneider JJ.. A comparison of serum antivenom concentrations after intravenous and intramuscular administration of redback (widow) spider antivenom. Br J Clin Pharm. 2008;65(1):139-143 A101. Chan A, Isbister GK, Kirkpatrick CMJ, Duffull SB. Assessing risk of a prolonged QT Interval – a survey of emergency physicians. Int J Emerg Med. 2008 Apr;1(1):35-41. A102. Isbister GK, Mills K, Friberg LE, Hodge M, O’Connor E, Patel R, Abeyewardene M, Eddleston M. Human methyl parathion poisoning Clin Toxicol. 2007;45(8):956-60. A103. Isbister GK, Burns J, Prior F, Ouvrier RA. Safety of nitrous oxide administration in patients with Charcot-Marie-Tooth disease. J Neurol Sci. 2008 May 15;268(1-2):160-2. A104. Herzig V, Khalife AA, Chong Y, Isbister GK, Currie B, Churchill T, Horner S, Escoubas P, Nicholson G, Hodgson WC. Intersexual variations in Northern (Missulena pruinosa) and Eastern (M. bradleyi) mouse spider venom. Toxicon. 2008 Jun 1;51(7):1167-77. A105. Isbister GK, Brown SGA, MacDonald E, White J, Currie BJ for the ASP Investigators. Current use of Australian snake antivenoms and frequency of immediate-type hypersensitivity reactions and anaphylaxis. Med J Aust 2008; 188(8):473-6 A106. Currie BJ, Canale E, Isbister GK. The effectiveness of pressure-immobilisation first aid for snakebite requires further study. Emerg Med Australas. 2008 Jun;20(3):267-70. A107. Isbister GK, Brown SGA, Miller M, Tankel A, MacDonald E, Stokes B, Ellis R, Nagree Y, Wilkes GJ, James R, Short A, Holdgate A. A randomised controlled trial of intramuscular versus intravenous antivenom for latrodectism – the RAVE study. QJM. 2008 Jul;101(7):557-65. A108. Winter KL, Isbister GK, Schneider JJ, Konstantakopoulos N, Seymour JE, Hodgson WC. An examination of the cardiovascular effects of an 'Irukandji' jellyfish, Alatina nr mordens. Toxicol Lett 2008;179(3):118-23. A109. Dowling J, Isbister GK, Kirkpatrick CMJ, Naidoo D, Graudins A. Population pharmacokinetics of intravenous, intramuscular and intranasal naloxone in human volunteers. Ther Drug Monit. 2008;30(4):490-6. IF:3.032 A110. Tanos PP, Isbister GK, Lalloo DG, Kirkpatrick CMJ, Duffull SB. A model for venom- induced consumptive coagulopathy in snake bite. Toxicon 2008;52(7):769-80. A111. Gildenhuys J, Lee M, Isbister GK. Does implementation of a paediatric asthma clinical practice guideline worksheet change clinical practice? Int J Emerg Med. 2009;2(1):33-9. A112. Page C, Duffull SB, Whyte IM, Isbister GK. Promethazine overdose: clinical effects, predicting delirium and the effect of charcoal. QJM. 2009;102(2):123-31 A113. O’Leary MA, Kornhauser RS, Hodgson WC, Isbister GK. An examination of the activity of expired and mistreated commercial Australian antivenoms. Trans R Soc Trop Med Hyg. 2009 Sep;103(9):937-42. A114. Isbister GK. Electrocardiogram changes and arrhythmias in venlafaxine overdose. Br J Clin Pharm. 2009;67(5):572-576 A115. Clunas S, Whitaker R, Ritchie N, Upton J, Isbister GK. Reviewing deaths in the Emergency department: deaths in the department or deaths within 48 hours. Emerg Med Australas. 2009;21(2):117-23 A116. Winter KL, Isbister GK, Jacoby T, Seymour JE, Hodgson WC. An in vivo comparison of the efficacy of CSL box jellyfish antivenom with antibodies raised against nematocyst-derived Chironex fleckeri venom. Toxicol Lett. 2009;187(2):94-8. A117. Konstantakopoulos N, Isbister GK, Seymour JE and Hodgson WC. A cell-based assay for screening of antidotes to and antivenom against Chironex fleckeri (box jellyfish) venom. J Pharmacol Toxicol Methods. 2009 May-Jun;59(3):166-70. A118. O’Leary MA, Isbister GK. Commercial monovalent antivenoms in Australia are polyvalent. Toxicon 2009;54:192-195. A119. Canale E, Isbister GK, Currie BJ. Investigating pressure bandaging for snakebite in a simulated setting: bandage type, training and the effect of transport. Emerg Med Australas. 2009 Jun;21(3):184-90 A120. Downes M, Healy P, Page CB, Bryant JL, Isbister GK. Code Black: A Structured Approach to the Agitated Patient in the Emergency Department. Emerg Med Australas. 2009;21(3):196-202 A121. Wajima T, Isbister GK, Duffull SB. A Comprehensive Model for the Humoral Coagulation Network in Humans. Clin Pharmacol Ther 2009 Sep;86(3):290-8. A122. Brown SGA, Caruso N, Borland ML, McCoubrie DL, Celenza A, Isbister GK. Clotting factor replacement and recovery from snake venom induced consumption coagulopathy. Intensive Care Med. 2009 Sep;35(9):1532-8. A123. Isbister GK, Duffull SB. Quetiapine overdose: predicting intubation, duration of ventilation, cardiac monitoring and the effect of activated charcoal. Int Clin Psychopharmacol. 2009 Jul;24(4):174-180 A124. Isbister GK, Brown SGA, Duffull SB. Failure of antivenom to improve recovery in Australian snakebite coagulopathy. QJM. 2009 Aug;102(8):563-8 A125. van Gorp F, Whyte I, Isbister GK. Clinical and electrocardiogram effects of escitalopram overdose. Ann Emerg Med. 2009 Sep;54(3):404-8. A126. Gan M, O’Leary MA, Brown SGA, Jacoby T, Spain D, Tankel A, Gavaghan C, Garret P, Isbister GK. Rough scale snake (Tropidechis carinatus) envenoming: a series of confirmed cases. Med J Aust. 2009 Aug 3;191(3):183-6 A127. Page C, Isbister GK. The Use of High Dose Insulin-Glucose Euglycaemia in Beta-Blocker Overdose - A Case Report. J Med Toxicol. 2009 Sep;5(3):139-43 A128. Kumar VVP, Oscarsson T, Friberg LE, Isbister GK, Hacket LP, Duffull SB. The effect of decontamination procedures on the pharmacokinetics of venlafaxine in overdose. Clin Pharmacol Ther. 2009 Oct;86(4):403-10. A129. O’Leary MA, Isbister GK. A turbidimetric assay for the measurement of clotting times of procoagulant venoms in plasma. J Pharmacol Toxicol Methods. 2010;61(1):27-31. A130. Isbister GK, Halkidis L, O'Leary MA, Whitaker R, Cullen P, Mulcahy R, Bonnin R, Brown SG. Human anti-snake venom IgG antibodies in a previously bitten snake handler, but no protection against local envenoming. Toxicon. 2010 Feb-Mar;55(2-3):646-9 A131. Stone SF, Cotterell C, Isbister GK, Holdgate A, Brown SGA. Elevated serum cytokines during human anaphylaxis: Identification of potential mediators of acute allergic reactions. J Allergy Clin Immunol. 2009 Oct;124(4):786-92.e4. A132. Isbister GK, Calver L, van Gorp F, Stokes B, Page CB. Inter-rater reliability of manual QT measurement and prediction of abnormal QT,HR pairs. Clin Toxicol (Phila). 2009 Nov;47(9):884-8. A133. Loten C, Jamcotchian M, Isbister GK, Marley J, Hullick C, Attia J, McElduff P. Adverse outcomes following Emergency Department discharge of patients with possible acute coronary syndrome. Emerg Med Australas. 2009;21(5):455-464 A134. Calver L, Stokes B, Isbister GK. The dark side of the moon. Med J Aust. 2009 Dec 1- 15;191(11-12):692-4 A135. Winter KL, Isbister GK, McGowan S, Konstantakopoulos N, Seymour JE, Hodgson WC. A pharmacological and biochemical examination of the geographical variation of Chironex fleckeri venom. Toxicol Lett. 2010;192:419–424 A136. Isbister GK, O'Leary MA, Hagan J, Nichols K, Jacoby T, Davern K, Hodgson WC, Schneider JJ. Cross-neutralisation of Australian brown snake, taipan and death adder venoms by monovalent antibodies. Vaccine. 2010 Jan 8;28(3):798-802 A137. Kulawickrama S, O’Leary MA, Hodgson,WC, Brown SGA, Jacoby T , Davern,K, Isbister GK. Development of a sensitive enzyme immunoassay for measuring taipan venom in serum. Toxicon. 2010 Jul;55(8):1510-8. A138. Isbister GK, Woods D, Alley S, O'Leary MA, Seldon M, Lincz LF. Endogenous thrombin potential as a novel method for the characterization of procoagulant snake venoms and the efficacy of antivenom. Toxicon. 2010 Aug 1;56(1):75-85. A139. Isbister GK, Balit CR, Macleod D, Duffull SB. Amisulpride overdose is frequently associated with QT prolongation and Torsades de Pointes. J Clin Psychopharmacol. 2010 Aug;30(4):391-5 A140. Page CB, Calver LA, Isbister GK. Risperidone overdose causes extrapyramidal effects but not cardiac toxicity. J Clin Psychopharmacol. 2010 Aug;30(4):387-90 A141. Calver LA, Downes MA, Page CB, Bryant JL, Isbister GK. The impact of a standardised intramuscular sedation protocol for acute behavioural disturbance in the emergency department. BMC Emerg Med. 2010 Jun 28;10:14. A142. Ireland G, Brown SGA, Buckley NA, Stormer J, Currie BJ, White J, Spain D, Isbister GK. Changes in serial laboratory test results in snakebite patients: when can we safely exclude envenoming? Med J Aust. 2010 Sep 6;193(5):285-90 A143. Isbister GK, Calver LA, Page CB, Stokes B, Bryant JL, Downes MA. Randomised comparison study of intramuscular droperidol versus midazolam for violence and acute behavioural disturbance – the DORM study. Ann Emerg Med. 2010 Oct;56(4):392-401 A144. Isbister GK, Scorgie FE, O'Leary MA, Seldon M, Brown SG, Lincz LF; for the ASP Investigators. Factor deficiencies in venom induced consumption coagulopathy resulting from Australian elapid envenomation: Australian Snakebite Project (ASP-10). J Thromb Haemost. 2010 Nov;8:2504-2513 A145. Churchman A, O’Leary MA, Buckley NA, Page CP, Tankel A, Gavaghan C, Holdgate A, Brown SGA, Isbister GK Clinical effects of red-bellied black snake (Pseudechis porphyriacus) envenoming and correlation with venom concentrations: Australian snakebite project (ASP-11). Med J Aust. 2010 Dec 6;193(11-12):696-700 A146. Kalam Y, Isbister GK, Mirtschin P, Hodgson WC, Konstantakopoulos N. An examination of the differential cytotoxicity of elapid snake venoms using a cell-based assay. J Pharmacol Toxicol Methods. 2011 Mar-Apr;63(2):137-42. A147. Coulter CV, Isbister GK, Duffull SB. The Pharmacokinetics of Methanol in the Presence of Ethanol – A Case Study. Clin Pharmacokin 2011 Apr 1;50(4):245-51. A148. Saul ME, Thomas PA, Dosen PJ, Isbister GK, O’Leary MA, Whyte IM, McFadden SA, van Helden DF. A pharmacological approach to first aid treatment for snakebite. Nat Med. 2011 Jun 26;17(7):809-11. A149. Kumar VV, Isbister GK, Duffull SB. The effect of decontamination procedures on pharmacodynamics of venlafaxine in overdose. Br J Clin Pharm 2011 Jul;72(1):125-32. A150. Maduwage K., Hodgson WC, Konstantakopoulos N, O'Leary MA, Gawarammana I, Isbister GK. The in vitro toxicity of venoms from South Asian Hump-nosed pit vipers (Viperidae: Hypnale). J Venom Res. 2011;2:17-23. A151. Joy JP, Coulter CV, Duffull SB, Isbister GK. Prediction of Torsades de Pointes from the QT interval: analysis of a case series of amisulpride overdoses. Clin Pharmacol Ther. 2011 Aug;90(2):243-5. A152. Berling I, Isbister GK, Calver L, Clunas S. Digital holter measurement of QT prolongation in ziprasidone overdose. Clin Toxicol (Phila). 2011 Aug;49(7):694-6. A153. Shen F, Coulter CV, Isbister GK, Duffull SB. A dosing regimen for immediate N- acetylcysteine treatment for acute paracetamol overdose. Clin Toxicol (Phila). 2011 Aug;49(7):643-7. A154. Lane J, O’Leary MA, Isbister GK. Coagulant effects of black snake (Pseudechis spp.) venoms and in vitro efficacy of commercial antivenom. Toxicon. 2011 Sep 1;58(3):239-46. A155. Casamento A, Isbister GK. Thrombotic microangiopathy in two tiger snake envenomations. Anaesth Intensive Care. 2011 Nov;39(6):1124-7. A156. Coulter CV, Farquhar S, McSherry C, Isbister GK, Duffull SB. Methanol and Ethylene Glycol Acute Poisonings – Predictors of Mortality. Clin Toxicol (Phila). 2011 Dec;49(10):900-6. A157. Isbister GK, White J, Currie BJ, O'Leary MA, Brown SG; for the ASP Investigators. Clinical effects and treatment of envenoming by Hoplocephalus spp. snakes in Australia: Australian Snakebite Project (ASP-12). Toxicon. 2011 Dec 1;58(8):634-40. A158. Calver L, Isbister GK. The Sedation Assessment Tool to score acute behavioural disturbance in the emergency department. Emerg Med Australas 2011 Dec;23(6):732-4011. A159. Gulati A, Faed JM, Isbister GK, Duffull SB. Development and evaluation of a prototype of a novel clotting time test to monitor enoxaparin. Pharm Res. 2012 Jan;29(1):225-35. A160. Berling I, Anscombe M, Isbister GK. Intravenous paracetamol toxicity in a malnourished child. Clin Toxicol (Phila). 2012 Jan;50(1):74-6. A161. Isbister GK, Prior F, Kilham HA. Restricting cough and cold medicines in children. J Paediatr Child Health. 2012 Feb;48(2):91-8. A162. Calver L, Dunlop A, Isbister GK. Individual patient assessment of methadone induced QT prolongation with digital holter recording. J Addict Med. 2012 Mar;6(1):92-3. A163. Van Gorp F, Duffull SB, Hackett LP, Isbister GK. Population pharmacokinetics and pharmacodynamics of escitalopram in overdose and the effect of activated charcoal. Br J Clin Pharmacol. 2012 Mar;73(3):402-10. A164. Barber C, Isbister GK, Hodgson WC. Solving the 'brown snake paradox': in vitro characterisation of australasian snake presynaptic neurotoxin activity. Toxicol Lett. 2012 May 5;210(3):318-23. A165. Isbister GK, Shahmy S, Mohamed F, Abeysinghe C, Karunathilake H, Ariaratnam A. A randomised controlled trial of two infusion rates to decrease reactions to antivenom. PLoS One 2012;7(6):e38739. Epub 2012 Jun 18 A166. Isbister GK, O’Leary MA, Elliott M, Brown SGA. Tiger Snake (Notechis spp) Envenoming: Australian snakebite project (ASP-13). Med J Aust. 2012 Aug 6;197(3):173-7 A167. Chaisakul J, Isbister GK, Konstantakopoulos N, Tare M, Parkington HC, Hodgson WC. In vivo and in vitro cardiovascular effects of Papuan taipan (Oxyuranus scutellatus) venom: exploring "sudden collapse" Toxicol Lett 2012 Sep 3;213(2):243-8. A168. Johnston CI1, O'Leary MA, Brown SGA, Currie BJ, Halkidis L, Whitaker R, Close BR, Isbister GK. Death adder envenoming causes neurotoxicity not reversed by antivenom - Australian Snakebite Project (ASP-16). PLoS Trop Neg Dis 2012 Sep;6(9):e1841 A169. Pycroft K, Isbister GK, O’Leary MA, Kuruppu S, Lawrence J, Smith AI, Greig Fry B, Hodgson WC. Toxinology of venoms from five Australian lesser known elapid snakes. Basic Clin Pharmacol Toxicol. 2012:Oct; 268-74. A170. Calver L, Isbister GK. Dexmedetomidine in the emergency department. Assessing safety and effectiveness in difficult to sedate acute behavioural disturbance. Emerg Med J. 2012:Nov; 915-8. A171. Isbister GK, Brown SGA. Bites in Australian snake handlers - Australian snakebite project (ASP-15). QJM. 2012: Nov;105(11):1089-1095. A172. Berling I, Whyte IM, Isbister GK. Oxycodone overdose causes naloxone responsive coma and QT prolongation. QJM 2013 Jan;106(1):35-41. A173. Maduwage K, Isbister GK, Silva A, Bowatta S, Mendis S, Gawarammana I. Epidemiology and clinical effects of hump-nosed pit viper (Genus: Hypnale) envenoming in Sri Lanka. Toxicon. 2013 Jan;61:11-5. A174. Gulati A, Isbister GK, Duffull SB. Effect of Australian elapid venoms on blood coagulation: Australian Snakebite Project (ASP-17). Toxicon. 2013 Jan;61:94-104. A175. Allen GE, Brown SGA, Buckley NA, O’Leary MA, Page CB, Currie BJ, White J, Isbister GK for the ASP Investigators. Clinical effects and antivenom dosing in Brown snake (Pseudonaja spp.) envenoming - Australian snakebite project (ASP-14). PLoS One. 2012;7(12):e53188 A176. Kornhauser R, Isbister GK, O'Leary MA, Mirtschin P, Dunstan N, Hodgson WC. Cross- Neutralisation of the Neurotoxic Effects of Egyptian Cobra Venom with Commercial Tiger Snake Antivenom. Basic Clin Pharmacol Toxicol. 2013 Feb;112(2):138-43. A177. Hart AJ, Isbister GK, Hodgson WC. In vitro neurotoxic effects of Pseudechis sp. venoms: a comparison of avian and murine skeletal muscle preparations. Toxicon. 2013 Mar 1;63:112-5. A178. O’Leary MA, Maduwage K, Isbister GK. Use of immunoturbidimetry to detect venom- antivenom binding using snake venoms. J Pharmacol Toxicol Methods. 2013 Mar 1;63:112- 5. A179. Chaisakula J, Isbister GK, Konstantakopoulos N, Hodgson WC. Differential myotoxic and cytotoxic activities of pre-synaptic neurotoxins from Papuan taipan (Oxyuranus scutellatus) and Irian Jayan death adder (Acanthophis rugosus) venoms. Basic Clin Pharmacol Toxicol. 2013 May;112(5):325-34. A180. Johnston CI, Brown SGA, O’Leary MA, Currie BJ, Greenberg R, Taylor M, Barnes C, White J, Isbister GK. Mulga snake (Pseudechis australis) envenoming: a spectrum of myotoxicity, anticoagulant coagulopathy, haemolysis and the role of early antivenom therapy - Australian Snakebite Project (ASP-19). Clin Toxicol. 2013 Jun;51(5):417-24 A181. Calver LA, Isbister GK. Parenteral sedation of elderly patients with acute behavioral disturbance in the emergency department. Am J Emerg Med 2013 Jun;31(6):970-3 A182. Hart AJ, Isbister GK, O'Donnell P, Williamson NA, Hodgson WC. Species differences in the neuromuscular activity of post-synaptic neurotoxins from two Australian black snakes (Pseudechis porphyriacus and Pseudechis colletti). Toxicol Lett 2013 Jun 7;219(3):262-8 A183. Isbister GK, Buckley NA, Page CB, Scorgie FE, Lincz LF, Seldon M, Brown SGA. A randomised controlled trial of fresh frozen plasma for treating venom induced consumption coagulopathy in Australian snakebite (ASP-18). J Thromb Haemost. 2013 Jul;11(7):1310-8 A184. Stone SF, Isbister GK, Shahmy S, Mohamed F, Abeysinghe C, Karunathilake H, Ariaratnam A, Jacoby-Alner TE, Cotterell CL, Brown SGA. Immune response to snake envenoming and treatment with antivenom; complement activation, cytokine production and mast cell degranulation. PLoS Negl Trop Dis. 2013 Jul 25;7(7):e2326. A185. Chaisakula J, Isbister GK, Kuruppu S, Konstantakopoulos N, Hodgson WC. An examination of cardiovascular collapse induced by Eastern brown snake (Pseudonaja textilis) venom. Toxicol Lett. 2013 Aug 29;221(3):205-11. A186. Maduwage K, Scorgie FE, Silva A, Shahmy S, Mohamed F, Abeysinghe C, Karunathilake H, Lincz LF, Ariaratnam A, Isbister GK. Hump-nosed pit viper (Hypnale hypnale) envenoming causes mild coagulopathy with incomplete clotting factor consumption. Clin Toxicol. 2013 Aug;51(7):527-31. A187. Duffull S, Isbister GK. Predicting the requirement for N-acetylcysteine in paracetamol poisoning from reported dose. Clin Toxicol (Phila). 2013 Sep-Oct;51(8):772-6. A188. Calver LA, Drinkwater V Isbister GK. A prospective study of high dose sedation for rapid tranquilisation of acute behavioural disturbance in an acute mental health unit. BMC Psychiatry. 2013 Sep 18;13:225. A189. Isbister GK, Maduwage K, Shahmy S, Mohamed F, Abeysinghe C, Karunathilake H, Ariaratnam A, Buckley NA. Diagnostic 20 minute whole blood clotting test (WBCT20) in Russell's viper envenoming delays antivenom administration. QJM 2013 Oct;106(10):925-32. A190. Brown SG, Stone SF, Fatovich DM, Burrows SA, Holdgate A, Celenza A, Coulson A, Hartnett L, Nagree Y, Cotterell C, Isbister GK. Anaphylaxis: clinical features and mediator release patterns. J Allergy Clin Immunol. 2013 Nov;132(5):1141-1149.e5. A191. O’Rouke KM, Correlje E, Martin CL, Robertson JD, Isbister GK. Point-of-care derived INR does not reliably detect significant coagulopathy following Australian snakebite. Thromb Res 2013 Nov;132(5):610-3. A192. Allen GE, Wilson S, Isbister GK. Paroplocephalus envenoming: a previously unrecognized highly venomous snake in Australia. Med J Aust 2013 Dec 16;199:792-4. A193. Li L, McGee RG, Isbister G, Webster AC. Interventions for the symptoms and signs resulting from jellyfish stings. Cochrane Database Syst Rev. 2013 Dec 9;12:CD009688 A194. Gulati A, Isbister GK, Duffull SB. Scale reduction of a systems coagulation model with an application to modelling pharmacokinetic-pharmacodynamic data. CPT Pharmacometrics Syst Pharmacol. 2014 Jan 8;3:e90 A195. Berling I, Isbister GK. Mirtazapine overdose is unlikely to cause major toxicity. Clin Toxicol (Phila). 2014 Jan;52(1):20-4. A196. O’Leary MA, Isbister GK. Detection of venom - antivenom (VAV) immunocomplexes in vitro as a measure of antivenom efficacy. Toxicon. 2014 Jan;77:125-32. A197. Cooper JM, Newby DA, Whyte IM, Carter G, Jones AL, Isbister GK. Serotonin toxicity from antidepressant overdose and its association with the T102C polymorphism of the 5- HT2A receptor. Pharmacogenom J 2014 Jan 7. doi: 10.1038/tpj.2013.47 A198. Chaisakula J, Isbister GK, Tare M, Parkington HC, Hodgson WC. Hypotensive and vascular relaxant effects of phospholipase A2 toxins from Papuan taipan (Oxyuranus scutellatus) venom. Eur J Pharmacol. 2014 Jan 15;723:227-33. A199. Brinkman DL, Konstantakopoulos N, McInerney BV, Mulvenna J, Seymour JE, Isbister GK, Hodgson WC. Chironex fleckeri (Box Jellyfish) Venom Proteins: Expansion of a Cnidarian Toxin Family that Elicits Variable Cytolytic and Cardiovascular Effects. J Biol Chem 2014 Feb 21;289(8):4798-812. A200. van Helden DF, Thomas P, Dosen PJ, Imtiaz MS, Laver DR, Isbister GK. Pharmacological Approaches that Slow Lymphatic Flow as a Snakebite First Aid. PLoS NTD 2014 Feb 27;8(2):e2722. A201. Maduwage K, O’Leary MA, Isbister GK. Diagnosis of snake envenomation using a simple phospholipase A2 assay. Sci Rep. 2014 Apr 29;4:4827. doi: 10.1038/srep04827 A202. Calver LA, Isbister GK. High dose droperidol and QT prolongation: analysis of continuous 12-lead recordings. Br J Clin Pharmacol. 2014 May;77(5):880-6. A203. Chiew A, Isbister GK. A coagulopathic dilemma: snakes or genes. Lancet. 2014 Jun 21;383(9935):2184. A204. Downes MA, Calver LA, Isbister GK. Intralipid therapy does not improve level of consciousness in overdoses with sedating drugs: A case series. Emerg Med Australas. 2014 Jun;26(3):286-90. A205. Hart AJ, Hodgson WC, O’Leary M, Isbister GK. Pharmacokinetics and pharmacodynamics of the myotoxic venom of Pseudechis australis (Mulga Snake) in the anesthetised rat. Clin Toxicol (Phila). 2014 Jul;52(6):604-10. A206. Lincz LF, Scorgie FE, Johnston CI, O’Leary M, Prasad R, Seldon M, Favaloro E, Isbister GK. Comparative Sensitivity of Commercially Available aPTT Reagents to Mulga Snake (Pseudechis australis) Venom. Pathology. 2014 Aug;46(5):444-9 A207. Isbister GK, Maduwage K, Page CB. Antivenom cross neutralisation in a suspected Asian pit viper envenoming causing severe coagulopathy. Toxicon. 2014 Nov;90:286-90. A208. O'Leary MA, Maduwage K, Isbister GK. Detection of venom after antivenom administration is largely due to bound venom. Toxicon. 2014 Nov 15;93C:112-118. A209. Isbister GK, Page CB, Buckley NA, Fatovich DM, Pascu O, Macdonald SPJ, Calver LA, Brown SGA on behalf of the RAVE Investigators. Randomized controlled trial of intravenous antivenom versus placebo for latrodectism: the second redback antivenom evaluation (RAVE- II) study. Ann Emerg Med. 2014 Dec;64(6):620-628.e2 A210. Cooper JM, Duffull SB, Saiao AS, Isbister GK. The pharmacokinetics of sertraline in overdose and the effect of activated charcoal. Br J Clin Pharmacol. 2014 Aug 26. doi: 10.1111/bcp.12500. [Epub ahead of print] A211. Calver LA, Drinkwater V, Gupta R, Page CB, Isbister GK. Randomised controlled trial of droperidol versus haloperidol for sedation of aggressive behaviour in acute mental health. Br J Psychiatry. 2014 Nov 13. pii: bjp.bp.114.150227. [Epub ahead of print] A212. Maduwage K, O’Leary MA, Scorgie FE, Shahmy S, Mohamed F, Abeysinghe C, Karunathilake H, Lincz LF, Gnanathasan CA, Isbister GK. Detection of venom after antivenom is not associated with persistent coagulopathy in a prospective cohort of Russell's viper (Daboia russelii) envenomings. PLoS Negl Trop Dis. 2014 (accepted September 2014) A213. Berling I, Isbister GK. Prolonged QT risk assessment in antipsychotic overdose using the QT nomogram. Ann Emerg Med (accepted Dec 2014) A214. Buckley NA, Whyte IM, Dawson AH, Isbister GK. A prospective cohort study of 26 years of Self-poisoning in Newcastle Australia, 1987-2012 - (“plus ça change, plus c'est la même chose”. Med J Aust (accepted Dec 2014) B. Reviews B1. Isbister GK, Dawson AH, Isbister JP. “Recommendations for the management of over- anticoagulation with warfarin. Emerg Med 2001 13:469-72 B2. White J, Warrell D, Eddleston M, Currie BJ, Whyte IM, Isbister GK. Clinical Toxinology – Where are we now ? J Toxicol Clin Toxicol 2003;41(3):263-276 B3. Isbister GK, Graudins A, White J, Warrell D. Antivenom treatment in arachnidism. J Toxicol Clin Toxicol 2003;41(3):291-300 B4. Smith AJ, Isbister GK. Antivenom symposium: editorial comment. Journal of Toxicology - Clinical Toxicology 2003;41(3):261-262 B5. Isbister GK, White J. Clinical consequences of spider bites: recent advances in our understanding. Toxicon 2004;43(5):477-492 B6. Isbister GK, White J, Currie BJ, Bush SP, Vetter RS, Warrell DA. Spider bites: addressing mythology and poor evidence. Am J Trop Med Hyg. 2005 Apr;72(4):361-364. B7. Isbister GK, Kiernan MC. Neurotoxic Marine Poisoning. Lancet Neurology. 2005 Apr;4(4):219-28 B8. Isbister GK, Buckley NA. The pathophysiology of serotonin toxicity in animals and humans: implications for diagnosis and treatment. Clin Neuropharm 2005 September/October; 28(5):205-214 B9. Isbister GK. Snake bite: a current approach to management. Aust Presc 2006;29(5):125-129 B10. Isbister GK. Spider bite: a current approach to management. Aust Presc 2006;29(6):154-156 B11. Isbister GK, Buckley NA, Whyte IM. Serotonin toxicity: a practical approach to diagnosis and treatment. Med J Aust 2007;187(6):361-5 B12. Vetter RS, Isbister GK. Medical Aspects of Spider Bites. Annu Rev Entomol. 2008 Jan 7;53:409-429. B13. Isbister GK Managing injuries by venomous sea creatures in Australia. Aust Prescr Oct 2007;30:117-21 B14. Kuruppu S, Smith AI, Isbister GK, Hodgson WC. Neurotoxins from australo-papuan elapids: a biochemical and pharmacological perspective. Crit Rev Toxicol. 2008 Jan;38(1):73-86. B15. Hodgson WC, Isbister GK. The application of toxins and venoms to cardiovascular drug discovery. Curr Opin Pharmacol. 2009 Apr;9(2):173-6. B16. Isbister GK. Procoagulant snake toxins: laboratory studies, diagnosis and understanding snake bite coagulopathy. Semin Thromb Hemost. 2009 Feb;35(1):93-103. B17. Isbister GK. Antivenom efficacy or effectiveness: the Australian experience. Toxicology. 2010 Feb 9;268(3):148-54. B18. Isbister GK. How do we use drug concentration data to improve the treatment of overdose patients? Ther Drug Monit. 2010 Jun;32(3):300-4. B19. Isbister GK. Snakebite doesn't cause DIC: coagulopathy and thrombotic microangiopathy in snake envenoming. Semin Thromb Hemost. 2010 Jun;36(4):444-51. B20. Isbister GK, Fan HW. Spider bite. Lancet. 2011 Dec 10;378(9808):2039-47. B21. Isbister GK, Kumar VV. Indications for single-dose activated charcoal administration in acute overdose. Curr Opin Crit Care. 2011 Aug;17(4):351-7 B22. Kumar VV, Isbister GK, Duffull SB. Introduction to pharmacokinetics in clinical toxicology. Methods Mol Biol. 2012;929:289-312. B23. Buckley NA, Isbister GK. Review: Application of heat or hot water reduces pain from jellyfish stings. Ann Intern Med. 2012 Dec 18;157(12):JC6-12. B24. Barber C, Isbister GK, Hodgson WC. Alpha Neurotoxins. Toxicon. 2013 May;66:47-58. B25. Isbister GK, Page CB. Drug induced QT prolongation: the measurement and assessment of the QT interval in clinical practice. Br J Clin Pharmacol. 2013 Jul;76(1):48-57. B26. Isbister GK, Page CB, McCoubrie D, Greene S, Brown SGA, Buckley NA. Treatment of snake bite in Australia: a practical approach to diagnosis and treatment. Med J Aust 2013;199: 763-768 B27. Buckley NA, Dawson AH, Isbister GK. Practice pointer: Serotonin syndrome. BMJ. 2014 Feb 19;348:g1626. B28. Isbister GK, Bawaskar HS. Scorpion Envenomation. N Engl J Med. 2014 Jul 31;371(5):457- 63. B29. Maduwage K, Isbister GK. Current treatment for venom induced consumption coagulopathy resulting from snakebite. PLoS Negl Trop Dis. 2014 Oct 23;8(10):e3220. B30. Berling I, Isbister GK. Haematological effects and complications of snake envenoming. Trans Med Rev (accepted September 2014). C. Chapters C1. Isbister GK. Caldicott DC. Trauma and Envenomation from Marine Fauna. In: Emergency Medicine: A Comprehensive Study Guide Ed: Tintinalli JE et al. 6th Edition McGraw-Hill New York. 2003 C2. Isbister GK, Kilham H. Overdose of Psychotropic Medications in Childhood. C3. Ken Nunn, Noel Cranswick, Geoff Isbister, Cybele Dey. Adverse Drug Reactions (ADRs) and Syndromes of Adverse Reaction. C4. Isbister GK. Marine Envenomation and Poisoning. In: Medical Toxicology 3rd Ed. Dart RC. Lippincott Williams & Wilkins, Philadelphia 2004 C5. Isbister GK. Other Arthropod Envenomation. In: Medical Toxicology 3rd Ed. Dart RC. Lippincott Williams & Wilkins, Philadelphia 2004 C6. Isbister GK. Spider Bite. In: Textbook of Adult Emergency Medicine; 3rd Ed. Ed: Cameron PA et al. Churchill-Livingstone, Edinburgh. 2009, 2013 C7. Isbister GK. Snake Bite. In: Textbook of Adult Emergency Medicine; 3rd Ed. Ed: Cameron PA et al. Churchill-Livingstone, Edinburgh. 2009, 2013 C8. Isbister GK. Trauma and Envenomation from Marine Fauna. In: Emergency Medicine: A Comprehensive Study Guide Ed: Tintinalli JE et al. 7th Edition McGraw-Hill New York. 2011; 1358-1366 C9. Isbister GK. Page CB. Beta blocker and calcium antagonist poisoning. In: Oxford Textbook of Critical Care, Webb A et al. 2nd Edition, Oxford University Press (UK). 2013 C10. Endom EE, Isbister GK. Marine envenomations from corals, sea urchins, fish, or stingrays. In: UpToDate, Basow, DS (Ed), UpToDate, Waltham, MA; latest version 23rd May 2013. C11. Marcus EN, Isbister GK. Jellyfish stings. In: UpToDate, Basow, DS (Ed), UpToDate, Waltham, MA; latest version 23rd May 2013. C12. Isbister GK. Marine envenoming. Oxford Desk Reference Toxicology. Eds Bateman et al. 2014 Oxford University Press C13. Isbister GK, Seifert S. Envenomation. Cecil’s Textbook of Medicine, 25th Edition. 2014 D. Letters to Peer-reviewed Journals D1. Isbister G, Gray M. Acute and recurrent skin ulceration after spider bite. Med J Aust 2000; 172:303-304. D2. Isbister GK. Spider bites in Australia. Emerg Med 2000 12: 72-3 D3. Isbister GK. Failure of regional intravenous calcium gluconate in the treatment of hydrofluoric acid burns of the hand. Ann. Emerg. Med 2000; 36 (4) : 398-99 D4. Isbister G, Whyte I, Dawson A. The Pediatric Forum: Pediatric Acetaminophen Poisoning. Arch Pediatr Adolesc Med. 2001 Mar;155(3):417-9 D5. Isbister GK, Whyte IM, Smith AJ. Olanzapine overdose. Anaesthesia 2001; 56:400-401 D6. Isbister G, Whyte I, Dawson A. Pediatric acetaminophen overdose. J Toxicol Clin Toxicol, 39(2):169-72, 2001 D7. Isbister GK, Whyte IM. Management of anticoagulant poisoning. Vet Hum Toxicol, 43(2):117, 2001 April D8. Isbister GK. “Spider mythology across the world” West J Med. 2001 Aug;175(2):86-7

D9. Isbister GK, Dawson A, Whyte IM. “Serotonin syndrome and 5-HT2a antagonism” Ann Pharm 2001 Sep ;35(9):1143-4 D10. Isbister GK, Prior FH, Clancy C., Dawson AH, Whyte IM, Smith AJ. “Neonatal paroxetine withdrawal syndrome or actually serotonin syndrome Arch Dis Child Fetal Neonatal Ed. 2001 Sep;85(2):F147-8. D11. Isbister GK, Dawson A, Whyte IM. Citalopram overdose, serotonin toxicity, or neuroleptic malignant syndrome? Can J Psych 2001 Sep;46(7):657-9. D12. Isbister GK, Balit C. “Ocular exposure to squashed spiders” Med J Aust. 2000; 175:391-2 D13. Isbister GK, Balit C. Effects of legislation restricting pack sizes of paracetamol on self poisoning. Authors did not look at effects on all deliberate and accidental self poisoning. BMJ. 2001 Sep 15;323(7313):633-4. D14. Isbister GK. Necrotic arachnidism in Australia. Toxicon. 2001 Dec;39(12):1941-2. D15. Isbister GK, McGettigan P, Dawson A. “A Fatal Case of Moclobemide-Citalopram Intoxication” J Anal Toxicol 2001 25(8); 716-7 (Letter) D16. Isbister GK. Serotonin syndrome, mydriasis, and cyproheptadine. Ann Pharmacother 2001 Dec ;35(12):1672 D17. Isbister GK, Dawson AH, Whyte IM. Serotonin syndrome induced by fluvoxamine and mirtazapine. Ann Pharmacother 2001 Dec ;35(12):1674 D18. Whyte IM, Isbister GK. Misdiagnosis of myoclonus in antidepressant induced serotonin excess., Vet Hum Toxicol 2001, 43(6): 375 D19. Isbister GK, Little M, Seymour J. Jellyfish stings. Vet Hum Toxicol 2001, 43(6): 373 D20. Prior FH, Isbister GK, Dawson AH, Whyte IM. “Serotonin toxicity with therapeutic doses of dexamphetamine and venlafaxine” Med J Aust 2002; 176:240-1

D21. Isbister GK, Whyte IM. Serotonin toxicity and malignant hyperthermia : role of 5-HT2 receptors. Br J Anaes. 2002; 88(4): 603 D22. Isbister GK, Whyte IM. Atypical Presentation of Risperidone Toxicity. Vet Hum Toxicol 2002; 44(1): 118-9 D23. Isbister GK, Dawson AH, Whyte IM. Hydroxychloroquine overdose : a prospective case series Am J Emerg Med 2002; 20(4):377-8 D24. Isbister GK, Dawson AH, Whyte IM. Neuroleptic malignant syndrome associated with risperidone and fluvoxamine. Ann Pharmacother 2002 Jul 36(7):1294 D25. Caldicott D, Isbister GK, Edwards N. Publication and Patriotism. ANZ J Surg 2002; 72:768 D26. Isbister GK, Currie BJ, Little M, Daly FF, Isbister JP. Coagulopathy from tiger snake envenoming and its treatment. Pathology. 2002;34(6):588-90 D27. McGettigan P, Isbister GK, Whyte IM. Adolescent Depression N Engl J Med 2003;348(5):473-4 D28. Isbister GK, McGettigan P, Harris I. Hyperbaric oxygen for acute carbon monoxide poisoning. N Eng J Med. 2003;348(6):557-560 D29. Isbister GK, Downes F Whyte IM. Regular medication and paracetamol overdose. Aliment Pharmacol Ther 2003 Feb;17(4):609-10. D30. Isbister GK, Whyte IM, Downes F, Dawson AH, McGettigan P. Paracetamol poisoning and the effect of coingestant drugs. Br J Clin Pharm 2003 Mar;55(3):325 D31. Isbister GK, Downes F Whyte IM. Olanzapine and serotonin toxicity. Psychiatry and Clinical Neurosciences 2003 Apr;57(2):241-242 D32. Little M, Murray L, Armstrong J, Dawson AH, Whyte IM , Isbister GK, Dowsett R, Graudins A, Daly F, Braitberg G. Clinical toxicology: ‘bones’ of contention. Critical Care and Resuscitation 2003 Mar;5:71-72 D33. Isbister GK. Comment: combination risperidone and SSRI-induced serotonin syndrome. Ann Pharmacother 2003 Oct;37(10):1531-2; D34. Balit CR, Isbister GK, Dawson AH, Daly FF, Whyte IM. Paracetamol availability. Med J Aust 2003;179(4):221-2; D35. Isbister GK. Whyte IM. Adverse reactions to mirtazapine are unlikely to be serotonin toxicity. Clin Neuropharmacol. 2003 Nov-Dec;26(6):287-8. D36. Isbister GK. Sublingual glyceryl trinitrate as prehospital treatment for hypertension in Irukandji syndrome. Med J Aust 2004;180(9):483 D37. Isbister GK, Ramasamy S, Seymour JS, Hodgson WC. Verapamil treatment in severe Chironex fleckeri stings. Toxicon. 2004 Dec 15;44(8):819-20. D38. Isbister GK Buckley NA. Adverse reactions to psychotropic medication: the literature continues to confuse. BMJ 2005 Apr 2;330(7494):790-1 D39. Gosslein S, Isbister GK. Treatment of Accidental Intrathecal Methotrexate Overdose. J Natl Cancer Inst. 2005 Apr 20;97(8):609-10; D40. Isbister GK, Vetter RS. Loxoscelism and Necrotic Arachnidism: more myths and minor corrections. Ann Emerg Med. 2005 Aug;46(2):205-6 D41. Buckley NA, Isbister GK, Juurlink DN. Hyperbaric Oxygen for Carbon Monoxide Poisoning: Evidence versus Opinion. Toxicol Rev. 2005;24(3):159-60. D42. Isbister GK, Tankel AS, White J, Little M, Brown SGA, Spain D, Gavaghan C, Currie BJ. High rate of immediate systemic hypersensitivity reactions to tiger snake antivenom. Med J Aust. 2006 Apr 17;184(8):419-20. D43. Downes M, Page C, Isbister G. Response to "use of lipid emulsion in the resuscitation of a patient with prolonged cardiovascular collapse after overdose of bupropion and lamotrigine". Ann Emerg Med. 2008 Jun;51(6):794-5\ D44. Page C, Isbister G. Dolasetron and QT interval. Emerg Med J. 2008 Oct;25(10):706 D45. Isbister GK, Scorgie FE, Seldon M, Lincz LF. Clinical relevance of brown snake (Pseudonaja spp.) Factor V escaping hemostatic regulation. Blood. 2009 Sep 17;114(12):2563 D46. Page CB, Wilson PA, Foy A, Downes MA, Whyte IM, Isbister GK Life-threatening hypokalaemia associated with ibuprofen-induced renal tubular acidosis. Med J Aust 2011; 194 (11): 613-614. D47. Isbister GK, Buckley NA, Brown SGA. A low volume, polyvalent antivenom for brown and tiger snake envenoming would make treatment simpler and safer. Med J Aust 2013; March 4 D48. Cubitt M, Armstrong J, McCoubrie D, White J, Williams V, Isbister GK. Point-of-care testing in snakebite: An envenomed case with false negative coagulation studies. Emerg Med Australas. 2013 Aug;25(4):372-3. D49. Isbister GK, Duffull SB. Understanding probability and exposure in paracetamol overdose risk assessment. Clin Toxicol (Phila). 2013 Dec;51(10):1240. D50. Isbister GK, Duffull SB. When is research clinical advice? Interpreting an exploratory study of paracetamol overdose. Clin Toxicol (Phila). 2013 Dec;51(10):1242. D51. Isbister GK, Bawaskar HS, Brown SG. Scorpion Envenomation. N Engl J Med. 2014 Oct 16;371(16):1559-60. Editorials/Commentaries D52. Isbister GK. Antivenoms, Anecdotes and Evidence. Med J Aust 2004;181(11-12):685-6. D53. Isbister GK, Adam J. Investigating the relationship between Emergency Departments and complementary and alternative medicine use in Australia. EMA 2004;16:378-81. D54. Isbister GK. Clinical trials in toxinology: More than a discussion between friends? Emerg. Med. Australas 2006;18(1):4-6 D55. Isbister GK. Snake antivenom research: the importance of case definition. Emerg Med J. 2005 Jun;22(6):399-400. D56. Knott JC, Isbister GK. Sedation of agitated patients in the emergency department. Emerg Med Australas. 2008 Apr;20(2):97-100 D57. Isbister GK. Pharmacokinetic-pharmacodynamic modeling in overdose patients – Is it worth the trouble? Clin Toxicol (Phila). 2010 Nov;48(9):896-7. D58. Isbister GK, Page CB. Early endoscopy or CT in caustic injuries: a re-evaluation of clinical practice. Clin Toxicol (Phila). 2011 Aug;49(7):641-2. D59. Brown SG, Isbister GK. Clinical research is a priority for emergency medicine but how do we make it happen, and do it well? Emerg Med Australas. 2014 Feb;26(1):14-8. D60. Isbister GK, Bies RR. Pharmacometrics: so much mathematics and why planes achieve their destinations with almost perfect results … Br J Clin Pharm 2014 Sep 16. doi: 10.1111/bcp.12514. [Epub ahead of print]

Community Involvement Media I have had extensive experience working with local and national media over the last 10 years.  Catalyst: I have done filming for Catalyst on 4 occasions including a 4 minute “profile” of my scientific work (2008), an 8 minute feature on the myth of the white-tail spider bite (2005), a 10 min segment on antivenom (2105), and a segment on the treatment of blue bottle stings with hot water (2008).  Local television (NBN): I have been interviewed for News stories on blue bottle stings, spider bite and snake envenoming.  Channel 9: “What’s Good For You” about treatment of blue bottle stings.  ABC Kids: I have provided advice to the ABC children’s programs regarding spiders.  Radio interviews: I have done over 100 radio interviews including BBC, local ABC radio, Radio National, State and country ABC radio and commercial radio stations in Newcastle, Sydney, and all capital cities in Australia  Radio features: “Background Briefing”; Local Newcastle Radio morning features on bites and stings.  Newspapers: I have had extensive coverage of my research in newspapers around Australia, with media releases for publications, media releases at conferences and as the contact point for Government media releases for Bites and Stings each Summer. Primary and Secondary Education  Short teaching sessions to pre-school and kindergarten classes at Jesmond and Merewether Public Schools on Spiders and spider bite, insects and snakes.  Advice to ABC on ABC kids programmes about spiders and the risk of spider bites.  Primary school teachers seminars at Taronga Zoo in 2006 and 2007  Speaking to students at high schools in Newcastle Governmental Policy/Guidelines  2015: NSW Guidelines for the management of Acute Behavioural Disturbance in the Emergency Department.  2013: NSW Guidelines for the management of Snake and Spider bites.  2007: Evaluation of a submission to the National Drugs and Poisons Scheduling Committee on “Sedating Antihistamines in children”  2005: NSW Guidelines for the management of Snake and Spider bites.  2004: Advisor to NSW Health on policy document on the treatment of Tick Paralysis  2003: contributed to a report to the Japanese government on redback spiders done by Dr. Robert Raven at the Queensland Museum.  2003: Report to the Federal Government on funding for venom and antivenom research. Postgraduate and undergraduate teaching: Postgraduate Teaching 1. University of Newcastle: 6 current students. 2. University of Otago: PhD student supervision. 3. University of Queensland, honours students in Pharmacy 4. Monash University: Honours and PhD students associate supervisor in the Department of Pharmacology: 5. Sydney University: Honours student in medicine 2003; PhD Student 2013-: 6. Specialist Registrar research training in clinical toxicology 7. John Hunter Hospital: RMO and Registrar teaching in emergency medicine and toxicology, and supervision of emergency medicine registrars in research projects undertaken to meet the requirement for the college. 8. Clinical toxinology short course (University of Adelaide): Faculty member for 2001, 2003, 2005, 2007, 2010, 2012. 9. Hyperbaric Course, Prince of Wales Hyperbaric Unit, Sydney: “Marine envenoming and poisoning.” (2004 -) 10. Course Tutor and Contributing Author for the Diploma/Master Course in Clinical Toxicology, University of Newcastle. Undergraduate Teaching 1. Clinical Pharmacology teaching, University of Newcastle: 2. Emergency Medicine teaching, University of Newcastle 3. Medical student teaching, University of Newcastle: 4. Summer vocational scholarship for medical and biomedical students: 5. Monash University, Pharmacology teaching: