Biotech Research solutions for biotech companies

Get the expertise, support, and tools you need to realize your vision Accelerate your journey with technical expertise, support and tools Your pioneering solutions will transform lives and improve humanity. To successfully navigate the path from discovery to development to commercialization requires trusted allies. With a portfolio of solutions that span your drug development workflow, Thermo Fisher Scientific brings scientific and technological expertise to advance customer outcomes. Our network of validated processes and innovative solutions is rooted in empirical data and designed to help you confidently deliver transformative therapies to those who depend on them. With Thermo Fisher as your ally, you can develop, grow, and succeed to benefit humankind.

Successfully navigate the path to commercialization

Discovery Development Clinical trials Commercialization

From creating research Leverage our tools, Our exceptional commitment When your product space infrastructure to services, and deep industry to delivering high-quality, is ready for market, advanced technologies expertise to accelerate end-to-end global clinical our comprehensive and custom scientific candidates, develop supply chain services from products and services services, we enable efficient and scalable Phase 1 to 3 can help you can support the most innovation while seeking processes, lower regulatory prepare for commercial exacting requirements— to bridge discovery and QC hurdles, manage launch, with the right tools whether you opt for research to translational risk, and successfully at the right time. in-house or outsourced science. prepare for clinical trials. manufacturing. Contents

Biotech 4

Expertise, support and tools

Therapeutics development 14

Cell therapy

Gene therapy

Immunotherapy

Small molecules

Biologics

Vaccines

Diagnostics development 28 Molecular diagnostics

Solutions for service providers 32 Contract research organizations

Contract development and manufacturing organizations

Services and support for instruments 36

Resources 39 Expertise Navigate challenges so you can meet your goals on time

We provide technical support for every step of your workflow. Our specialists apply their deep technical knowledge to help address your challenges so that you can meet your goals on time and within budget. We work with you to keep you up to date on the latest innovations, install your instruments, and provide post-sale support both in person and remotely.

• Tailored demos, workflows, and solutions that will meet your unique goals

• Scientific and applications support in the field and on site, to get you started quickly and easily

• Remote and in-person technical support to minimize downtime

• On-demand, virtual, and face-to-face training to equip you with the knowledge you need to advance

4 Biotech

Quality Helping ensure you get it right the first time

Quality is inherent in all that we do. Through continual improvement, validation, qualification services, and compliance with global regulations and standards, our high-quality solutions and services produce results you can trust.

• cGMP-compliant solutions help ensure consistent and reliable results

• Instrument calibration services help keep your equipment running accurately and in optimal condition

• Services to ensure compliance of your lab equipment and analytical instrumentation with GLP/GMP, GxP, 21 CFR Part 11, ISO, and other key regulations minimize the risk of failed audits for your critical instruments and laboratory equipment

• Traceable documentation (e.g., Certificate of Analysis) helps ensure quality and confidence in results

• Stringent quality management systems in our manufacturing sites (e.g., ISO 9001, ISO 13485, GMP, FDA registration) help ensure we meet the quality standards you expect

Research solutions for biotech companies 5 Productivity Stay focused on the science and meet your milestones faster

Managing your inventory, ordering, and instruments takes up valuable time and resources. We have a range of robust productivity solutions that will simplify and strengthen these processes for you, so you have more time to focus on the science.

• The thermofisher.com website and our eProcurement connections make online ordering quick and simple whether you’re remote or in the lab, for single or multiple users

• On-site stocking through the Supply Center by Thermo Fisher Scientific ensures that products are available in your labs when you need them

• Cloud-based analysis solutions enable you to access, share, manage, and analyze your data quickly and securely even if you’re not in the lab

• Smart instrumentation and remote services minimize any instrument downtime and keep your lab running

• Automation options for our instrumentation mean you can scale up quickly and easily

6 Biotech

Innovation Fueling your innovation with solutions that help you remain competitive

Our cutting-edge technologies, analytical instruments, and diagnostics enable you to push the boundaries of innovation.

• Industry-leading R&D investment of $1B annually and 5,700 scientists and engineers provide you with access to the latest technologies that will help you to move faster and more efficiently; investment areas include cell and gene therapy, precision medicine, material sciences, immuno-oncology, structural biology, and molecular diagnostics

• Collaborations with industy-leading customers and key opinion leaders help ensure that innovations are customer-centric and solve your complex challenges

• Our global scale enables unmatched capabilities in key scientific areas like precision medicine, so you can streamline your workflow and save time with solutions that work seamlessly together

Research solutions for biotech companies 7 Product development at scale Ease your transition across the entire product development pipeline with access to commercial-use rights, assurance of superior input materials, and proven quality assurance standards to help achieve regulatory compliance Science at scale Product development at scale Our solutions enable more from less,P androduct scaleProduct withEase youdevelopment towardyour development t rcommercialization.ansition across at atOurthe scale goalenti isre to p helproduct you development improve data quality, increase reproducibility, and pipelineshorten time-to-results. with access These to comme tools helprcial-use increase rights, productivity assu rance of Sample processingEase at Easeyour scale yourtransition transition ac acrossross the the enti entirree prroductoduct development development Outsourcing at scale of individualEnhance scientists your pandroductivity enable you and to generate gener superiorasuperiorte superior results input within mat erials,an expected and ptimeline.roven Pleasequality find assu rance some of our featured solutions below.pipelinepipeline with with access access to tcommeo commercial-usercial-use rights,rights, assu assurancerance of of outcomes with advanced-performance,standa rds to help achieve regulatory compliance experts, and remove barriers of needing to superiorsuperior input input ma tmaerials,terials, and and p provenroven quality assu assurancerance high-throughputP solutionsroduct developmentstandards to help at achieve scale regulatory compliance acquire new skills and instrumentation Sample processing standaProductrds to help development achieve regulatory compliance Ease your transition across the entire product development Sample processing at scalepipeline with accessProduct to comme developmentrcial-use rights, assu atOriginalr ancescale equipmentScience of manufacturer at scale Outsourcing at scale superior input materials, and proven quality assurance Enhance your productivity and generate superior Ease your transitionvs. Pacrroductoss the enti developmentre product development at scale Sample processing at scalestandards to help achieve regulatory compliance Outsourcing at scale outcomes with advanced-peMultiwell plate rformance, pipeline with access Easeto comme your trrcial-useansition rights,across assu the rentiancere pofr oduct development experts, and remove barriers of needing to Sample pEnhancerocessing your productivity at scaleformat and solutions generate superior Outsourcing at scale high-throughput solutions superior input materials,pipeline and withproven access quality to commeassurancercial-use rights, assurance of acquire new skills and instrumentation Enhance youroutcomes productivity with advanced-peand generartformance,e superior Solutions that meet regulations Commercial supply experts, and remove barriers of needing to high-throughput solutions standards to help achievesuperior regula inputto rmay complianceterials, and proven quality assurance acquire new skills and instrumentation Sampleoutcomes p withrocessing advanced-pe at scalerformance, standaSciencerds to help at achieve scale regulatory compliance Outsouerxpecingrts, at and scale remove barriers of needing to high-throughput solutions acquire new skills and instrumentation Enhance your productivity and generate superior Productvs. developmentScience at scale at scale outcomes with advanced-peSample prformance,rocessing Processing at more scalesamples Easevs. your transition across the entire product development experts, and remove barriersOutsou of needingr cingto at scale high-throughput solutions in shorter times acquire new skills and instrumentation Enhance your productivitySample and gene processingrate superiorpipeline at with scale access to commeSciencercial-use rights, at assu scalerance of Outsourcing at scale outcomes with advanced-peEnhancer formance,your productivityvs. superior and inputgene rmaatet erials,superior and proven quality assurance experts, and remove barriers of needing to high-throughput solutionsoutcomes with advanced-pestandarformance,ds to helpScience achieve regula at toscalery compliance acquire new skillsexpe andrts, instrumentation and remove barriers of needing to high-thMultiplroughputvs. exing solutions at scale acquire newP skillsroduction and instrumentation at scale GetKingFisher the Purification most Systemsout of your precious samples Science at scale Drive performance and achieve optimal Sample processing at scale vs. Science at scale Outsourcing at scalebioprocessing outcomes with our custom accuracy and reduced variability through services irrespective of batch size Enhance your productivity and generate superior vs. simultaneous measurements outcomes with advanced-performance, experts, and remove barriers of needing to high-throughput solutionsMultiplexing at scale acquire new skills and instrumentationProduction at scale Get the most out of your precious samples Drive performance and achieve optimal Multiplexing at scale Data managementSolutions that enable at scale Production at scale Multiplexing bioprocessing outcomes with our custom Get the most out of your precious samples Science atEasily scale manageyou to scaleyour toward data and collaborate with partners Drive performance and achieve optimal accuracy and reduced variability through services irrespective of batch size vs. across a spectrumcommercialization of platforms with secure, cloud-basedbiop rocessing outcomes with our custom simultaneous measurements accuracy and reduced variability through instrumentation and software services irrespective of batch size MultiplMultiplexingexingsimultaneous at atscale scale measurements Production at scaleProduction at scale Solutions to simultaneously detect multiple GetGet the the most most out out of your of your precious precious samplestargets samples of interest in a single sample Data management at scale Drive performance andDrive achieve pe optimalrformance and achieve optimal Multiplexing at scale DataEasily management manage your data and collaborate with partners bioprocessing outcomesbiop withrocessingP ourroduction custom outcomes at scale with our custom accuracy and reduced variability through Data management at scale services irrespective of batch size Data analysisacross and storage a spectrum solutions of platforms with secure, cloud-based accuracy andGet reduced the most variability out of Multiplyour th rpoughreciouse xing samples at scale Easily manage your data and collaborate with partners Drive performanceservices and irachieverespectiveP optimalroduction of batch siatze scale simultaneous measurements instrumentation and software simultaneous measurements Get the most out of your precious acsamplesross a spectrum of Cloud-basedplatforms apps with secure, cloud-based bioprocessing outcomesDrive with pe ourrformance custom and achieve optimal accuracy and reduced variability through coupled with software services irrespectivebioprocessing of batch outcomes size with our custom Solutions to detect results from instrumentation and andsoftwa instrumentsre with simultaneous measuaccurmultipleementsr samplesacy and in a single reduced run Data variability management through at scaleremote access services irrespective of batch size simultaneous measuEasilyrements manageData your management data and collaborate withat pascalertners Multiplexing at scale across a spectrumEasily Datamanage of platforms management your with data secu andre, collaboatcloud-based scalerate with partners Production at scale instrumentation and software Get the most out of your precious samples acrossEasily a spectrum manage yourof platforms dataData and management collabowith securate withre, cloud-based pa atrtners scale Drive performance and achieve optimal instrumentationacross a spectrum and softwa ofEasily platformsre manage with your secu datare, cloud-based and collabor ate withbiop partnersocessing outcomes with our custom accuracy and reduced variability through services irrespective of batch size 8 instrumentation and acsoftwaross rae spectrum of platforms with secure, cloud-based simultaneous measurements instrumentation and software

Data management at scale Easily manage your data and collaborate with partners across a spectrum of platforms with secure, cloud-based instrumentation and software Product development at scale Product development at scale Ease your transition across the entire product development Ease your transition across the entire product development pipeline with access to commercial-use rights, assurance of pipeline with access to commercial-use rights, assurance of Biotech superior input materials, and proven quality assurance superior input materials, and proven quality assurance standards to help achieve regulatory compliance standards to help achieve regulatory compliance

Product development at scale Sample processing at scale Ease your transition across the entire product development Sample processing at scale SampleOutsouEnhancer yourcing p productivityrocessing at scale and generate at superior scale outcomes with advanced, Outsourcing at scale pipeline with access to commercial-use rights, assurance of high-throughput solutions. Enhance your productivitysuperior and input gene marateerials, superior and proven Pqualityroduct assu rancedevelopment at scale Enhance your productivity and generate superior outcomes with advanced-performance, experts, and remove barriers of needing to Product development at scale standards to help achieve regulatory Easecompliance your transition across the entire product development outcomesSample isolation with and advanced-pe quantification rformance, experts, and remove barriers of needing to high-throughput solutions acquire new skills and instrumentation™ ™ Outsourcing • Thermo Scientific KingFisher Purification Systems—Semi-automated or fully Ease your transition across the entire product development pipeline with access to commercial-use rights, assurance of high-thautomatedroughput purification solutions systems for extracting 24 or 96 samples per run of DNA, RNA, acquire new skills and instrumentation superior input materials, and proven quality assurance Custom services for R&D protein, or cells. Get more done in less time by using pipeline with access to commercial-use rights, assurance of ™ ™ standards to helpScience achieve regula atto rscaley compliance Applied Biosystems MagMAX nucleic acid superior input materials, and proven quality assurance Sample processing at scale vs. Outsourcing at scale isolation kits and reagents on KingFisher systems. Enhance your productivity and generate superior Product development at scale These kits have been optimized for use on these Science at scalestandards to help achieve regulatory compliance Ease your transition across the entire product development instruments and have fully automated protocols. vs. outcomes with advanced-performance, experts, and remove barriers of needing to ™ ™ pipeline with access to commercial-use rights, assurance of • Invitrogen Dynabeads Magnetic Beads— high-throughput solutions Sample processing at scale acquire new skills and instrumentation OutsouKingFisher instrumentsrcing withat Dynabeads scale magnetic superior input materials, and proven quality assurance beads offer the best balance of high yield and reproducibility with low nonspecific binding, Enhance your productivity and generate superior Product development at scale standards to help achieve regulatory compliance which is one reason they have become the gold standard for immunoprecipitation using outcomes with advanced-performance,Science at scale experts, and removemagnetic barriersbeads. of needing to Sample processing at scaleEase your transition across the entire product development Outsourcing at scale Product development at scale ™ ™ high-throughputvs. solutions acquire new• Thermo skills Scientific and instrumentation Varioskan LUX Multimode Microplate ReaderEnhance—Get high-throughput your productivity and genepipelinerate superior with access to commercial-use rights, assurance of Ease your transition across the entire product development DNA, RNA, and protein quantification by scanning 96-well and 384-well plates in 15 and 45 seconds, respectively, using different detection modes. outcomes with advanced-performance, experts, and remove barriers of needing to pipeline with access to commercial-use rights, assurance of superior input materials, and proven quality assurance Sample processing at scale OutsouPharmar servicescing at scale ™ ™ superior input materials, and proven quality assurance Science at scale • Applied Biosystems ProFlex PCR System—Thermal cycler withhigh-th ultimate flexibilityroughput and solutions standards to help achieve regulatory compliance acquire new skills and instrumentation Enhance your productivity and generate superior throughput, from 3 x 32-well block to dual 384-well for high-throughput screening needs. standards to help achieve regulatvs.ory compliance outcomes with advanced-performance, experts, and remove barriers of needingGenetic t oanalysis high-throughput solutionsMultiplexing at scale acquire new skills and instrumentationP•r oductionApplied Biosystems at™ 3730 scale DNA analyzers—96- or 384-well Science at scale Get the most out of your precious samples Drive performanceplate-based and capillary achieve electrophoresis optimal instrument with integrated plate stacker for 48-hour uninterrupted runs. vs. Production bioprocessing outcomes with our customSample processing at scale Outsourcing at scale Sample processing at scale Science at scale Outsourcing at scale • Applied Biosystems™ TaqMan ® array cards, plates, ™ Enhance your productivity and generate superior Enhance your productivity and generateaccu superiorracy and reduced variabilityvs. through servicesOpenArray irrespective technology of batch—96- or si 384-wellze plates or cards pre-spotted with dried-down assays; outcomes with advanced-performance,simultaneous measurements experts, and remove barriers of needing to Multipldeliver resultsexing in only 30–45 at min. scaleoutcomes with advanced-performance, Perxpeoductionrts, and remove at scale barriers of needing to ™ high-throughput solutions acquire new skills and instrumentation Get• theIon Torrent most next-generation out of your sequencinghigh-th precious (NGS)roughput systems samples—Complementary, solutions automated NGS Drive performanceacqui andre achievenew skills optimal and instrumentation Multiplexing at scale Production at scale solutions to support a broad range of applications and throughput needs. Data management at scale bioprocessing outcomes with our custom Get the most out of your precious samples Drive performance and achieveCustom products optimal Cell analysis Science at scaleEasily manage your data and collaborate with partners accu• Invitrogenracy and™ Attune reduced™ NxT Flow Cytometer variability with Invitrogen through™ services irrespective of batch size bioprocessing outcomes with our custom ™ Science at scale vs. across a spectrum of platforms with secure, cloud-based simultaneousCytKick Max Autosampler measu—Processrements up to 21 plates accuracy and reduced variability throughMultipl exing at scale services irrespective of batch size P(96-well)roduction per day* with acoustic at scale hydrodynamic focusing vs. instrumentation and software flow cytometry. simultaneous measurements Get the most out of your precious samples Drive performance and achieve optimal • Thermo Scientific™ CellInsight™ CX7 LZR High-Content Screening Platform— bioprocessingScan outcomes a 96-well plate with within our 3.5 cusminutestom in confocal setting and perform simultaneous Bulk production services Data management at scale accuracy and reducedData variability management through at scale servicesimage-to-data irrespective analysis. of batch size simultaneous measurements Easily manage your data and collaborate with partners Protein analysis Easily manage your data and collaborate with partners Multiplexing at scale Production at scale• Thermo Scientific™ EasyPep™ 96 MS Sample Prep Kit—Automation-compatibleMultipl 96-wellexing plate- at scale Production at scale across a spectrum of platforms with secure, cloud-based based mass spectrometry sample preparation in less than 5 hours. across a spectrum of platforms with secure, cloud-based Get the most out of your precious samples Drive performance and achieve optimal instrumentation and software Data management at scale • Higher-throughput western blotting solutions—Separate, transfer,Get process, the and most quantitate outinstrumentation of your precious and samples software Drive performance and achieve optimal bioprocessing outcomes with our custom Easily manage your data and collaborate with partners Production up to 2 x 26 samples per run; walk-away processing saves about 10 repetitive hands-on steps bioprocessing outcomes with our custom accuracy and reduced variability through seplatformsrvices irrespective of batchover si theze course of 4 hours. simultaneous measurements across a spectrum of platforms with secure, cloud-based accuracy and reduced variability through services irrespective of batch size Multiplexing at scale instrumentation and software Production at scale * Based on an 8-hour day under normal conditions. simultaneous measurements Get the most out of your precious samples Data management at scale Drive performance and achieve optimal bioprocessing outcomes with our custom Multiplexing at scale Production at scale Easily manage your data and collaborate with partners accuracy and reduced variability through services irrespective of batch size Get the most out of your precious samples Data management at scale Drive performance and achieve optimal across a spectrum of platforms with secure, cloud-based Research solutions for biotech companies 9 simultaneous measurements instrumentation and software Easily manage your data and collaborate with partnersbiop rocessing outcomes with our custom accuracy and reduced variability through across a spectrum of platforms with secure, cloud-based services irrespective of batch size Data management at scale simultaneous measurements instrumentation and software Easily manage your data and collaborate with partners across a spectrum of platforms with secure, cloud-based instrumentation and software Data management at scale Easily manage your data and collaborate with partners across a spectrum of platforms with secure, cloud-based instrumentation and software Product development at scale EaseProduct your tr ansitiondevelopment across the at enti scalere product development Ease your transition across the entire product development pipelinepipeline withwith accessaccess to t commeo commercial-usercial-use rights, rights, assurance assu ofr ance of superiorsuperior inputinput mamaterials,terials, and and proven proven quality quality assurance assu rance Product development at scale standastandardsrds to helphelp achieve achieve regula regulatory tcomplianceory compliance Ease your transitionProduct across the development entire product development at scale pipeline with accessEase to your comme transitionrcial-use ac rights,ross the assu entirancere p rofoduct development Multiplexingsuperior options input mapipelineterials,Sample andwith p accessroven pr qualityocessing to comme assu rratancecial-use scale rights, assurance of Outsourcing at scale Get the most out of your preciousSample samples with p multiplexrocessing platforms that offer at data scaleaccuracy and Outsourcing at scale standards to helpsuperior achieveEnhance input regula mayourtortyerials, p complianceroductivity and andproven gene qualityrate superior assu rance reduced variability throughEnhance simultaneous measurement. your productivity Our solutions detect and multiple gene analytesrate superior from a single sample simultaneouslystanda and analyzeroutcomesds multiple to help samples with achieve inadvanced-pe a single run. regularformance,tory compliance experts, and remove barriers of needing to Genetic analysis outcomes withhigh-th advanced-peroughputCell analysis solutionsrformance, acquire newexpe skillsrts, andand instrumentation remove barriers of needing to • Applied Biosystems™ Clariom™ D Assay—The most comprehensive • Invitrogen™ EVOS™ M7000 Imaging System—Acquisition in multiple coverage, detecting all known high-thgenes, exons, androughput splice variants for solutions fluorescence and transmitted light channels with a choice of more than acquire new skills and instrumentation deep and broad transcriptome analysis and biomarker discovery—all 20 LED cubes. Sample processing at scale from a minimum input of 50 ng RNA. Outsourcing at scale • Invitrogen™ Attune™ NxT Flow Cytometer with panel builder—Up to Science at scale Enhance your productivity and generate superior • Applied Biosystems™ Clariom™ S Assay—Detects constitutive 14-color detection with free antibody panel design supportvs. tool. exons—those exons expressed in all known, well-annotated Sample processing at scale • Thermo Scientific™ CellInsight™ CX7 LZR High-Content Screening Outsourcing at scale transcript isoforms of genes for simple gene-level expression profiling, Science at scale outcomes with advanced-performance, Platform—7-color laser excitation for cell-level multiplex phenotyping. experts, and remove barriers of needing to Enhance your productivity and generawithte a minimumsuperior input of 50 ng RNA. ™ vs. high-throughput solutions • Invitrogen flow cytometry antibodies, assays, and reagents—Our acquire new skills and instrumentation • Applied Biosystems™ GeneChip™ WT Pico Kit—Detects from a comprehensive collection of antibodies, assays, beads, and buffers outcomes with advanced-performance,minimum input of 0.01 ng RNA, or 0.5 ng for FFPE samples. experts, and remove barriers of needing to supports leading research areas. high-throughput solutions • Applied Biosystems™ Platinum™ Multiplex PCR Master Mix— acquire new skills and instrumentation Designed specifically for endpoint multiplex PCR with minimal Protein analysis optimization. Amplifies up to 20 ampliconsScience in a single reaction. at• Invitrogen scale™ iBright™ FL1500 Imaging System—Multichannel fluorescence vs. • Invitrogen™ QuantiGene™ Plex Gene Expression Assay—Gene multiplexing enables imaging up to 4 expression measurement directly from sample, of up to 80 targets proteins or protein variants in a single per sample. Science at scale western blot. • Ion AmpliSeq™ andvs. Ion Torrent™ • Thermo Scientific™ TMTpro™ 16plex Label Reagent—Detecting Oncomine™ NGS assays—Simple, 16 targets simultaneously results in analysis twice as fast as equivalent versatile technology helps you target label-free mass spectrometry. tens to hundreds of genes and sequence challenging samples with low input • Invitrogen™ ProcartaPlex™ multiplex immunoassays—Measure up requirements across mutation types. Multiplexingto 65 protein at targets scale from a single sample of as little as 25 µL in volume. Production at scale Get the most out of your precious samples Drive performance and achieve optimal bioprocessing outcomes with our custom accuracy and reduced variability through services irrespective of batch size Multiplesimultaneousxing at measuscalerements Production at scale Data management atGet scale the most out of your precious samples Drive performance and achieve optimal Easily manage your data and collaborate with partners across a spectrum of platforms with secure, cloud-based instrumentation and software. Data management at scale bioprocessing outcomes with our custom Multiplexing at scale Cloud-based apps and software,accu and instrumentsracy and with reduced variability through Easily manage your dataPr oductionand collaborate atwith scale partners services irrespective of batch size remote access Get the most out of your precious samples • Instruments with simple and intuitivesimultaneous software can be used tomeasu analyze rements across a spectrumDrive pe rofformance platforms and with achievesecure, cloud-based optimal data away from the bench. Software integration with the Connect instrumentationbioprocessing and softwa outcomesre with our custom Multiplexing at scale cloud-based platform provides a convenient, centralized analysis Production at scale accuracy and reduced variability through and data management solution, enabling you to find more biological services irrespective of batch size Get the most out of your precious samplesinformation in your data. Drive performance and achieve optimal simultaneous measurements Data management at scale bioprocessing outcomes with our custom Easily manage your data and collaborate with partners accuracy and reduced variability through services irrespective of batch size Data storage and management solutions across a spectrum of platforms with secure, cloud-based simultaneous measurements Data management at scale• Connect provides secure, cloud-based data storage, scientific analysis apps, and peer collaboration tools, creating bold new efficiencies instrumentation and software Easily manage your data and collaboin thera lab.te with partners across a spectrum of platforms with secure, cloud-based instrumentation andData softwa managementre at scale 10 Easily manage your data and collaborate with partners across a spectrum of platforms with secure, cloud-based instrumentation and software Product development at scale Ease your transition across the entire product development Product development atP scaleroductpipeline development with access to comme atr cial-usescale rights, assurance of Ease your transition across the entiEasere product yoursuperior tdevelopmentransition input acmartoss erials, the and enti prrovene product quality developmentassurance pipeline with access to commercial-usepipeline rights, standawith assu accessrdsr anceto help to of commeachieve rrcial-useegulatory rights,compliance assurance of superior input materials, and provensuperior quality assuinputr ancematerials, and proven quality assurance standards to help achieve regulatorstanday compliancerds to help achieve regulatory compliance Sample processing at scale Outsourcing at scale Enhance your productivity and generate superior Sample processing at scale outcomes with advanced-performance, Outsourcing at scaleexperts, and remove barriers of needing to Sample prhigh-thocessingroughput solutionsat scale acquire newOutsou skills andr instrumentationcing at scale Enhance your productivity and geneEnhancerate superior your p roductivity and generate superior outcomes with advanced-performance,outcomes with advanced-performance, experts, and remove barriers of needingexpe tor ts, and remove barriers of needing to high-throughput solutions Science at scaleacquire new skills and instrumentation high-throughput solutions vs. acquire new skills and instrumentationBiotech

Science at scale Science atProduction scale at scale vs. vs. Product developmentDrive performance and achieveat scale optimal bioprocessing outcomes, regardless of batch size, with our Ease your transitioncustom acservices.ross the entire product development Custom antibody development Single-use bioprocessing pipeline with access• The Thermo to commeFisher Scientificrcial-use custom rights, assurance of • Single-use technologies have been proven to be robust and superior input maantibodyterials, service and offers p rcustomizedoven quality assurance scalable from lab/scale-up to cGMP production applications, production, purification, and conjugation including bioprocessing equipment and automation, flexible standards to helpof polyclonal,achieve monoclonal, regula recombinant,tory compliance containment, and rigid containment product portfolios. and flow antibodies.

Gibco™ custom cell culture media Multiplexing at scale • We are committed to meeting your toughest challenges Production at scale Sample processing at scaleProduct development at scalewith high-performing Gibco™ products and services Outsourcing at scale Get the most out of your precious samples Ease your transition across the entire prcustomizedoduct development to your research and production needs. Drive performance and achieve optimal Enhance your productivity and generatpipelinee superior with access to commercial-use rights, assurance of bioprocessing outcomes with our custom accuracy andoutcomes reduced variability with advanced-pe through rformance,superior input materials, and proven quality assurance services irreespectivexperts, and of batch remove size barriers of needing to Multiplexing at scale simultaneoushigh-th measurroughputements solutions standards to help achieve regulatory compliance Production at scale acquire new skills and instrumentation Get the most out of your preciousMultipl samples exing at scale Drive performance and achieve optimal Production at scale Get the most out of your precious samples Drive performance and achieve optimal Data management atOutsourcing scaleSciencebioprocessing opportunities at outcomes scale with our custom Sample processing at scale Outsoubioprrocessingcing at scaleoutcomes with our custom accuracy and reduced variability through vs. Increase efficiencyse byr vicespartnering irr espectivewith experienced of batch size accuracy and reducedEnhance variability your productivity through and generate superior Easily manage your data and collaborate with partners services irrespective of batch size simultaneous measurements outcomes with advanced-performance, across a spectrum of platformsprofessionals, with secur ande, cloud-based remove inhibitions associateexpe withrts, and remove barriers of needing to simultaneous measurements acquiring new skills and instrumentation. Our wide high-throughput solutions instrumentation and software acquire new skills and instrumentation range of service capabilities leverages a diverse portfolio Data management at scale Science at scaleof quality and consistency, built by some of the most Data management at scalerecognized life science brands in the industry, Easily manage your data and collabovs. rate with partners including the Applied Biosystems™, Invitrogen™, across a spectrum of platforms withEasily secu rmanagee, cloud-based your data and collaboProductandra Gibcote with™ brands. development par Findtners out more on page at12. scale instrumentation and software across a spectrumProduct of platforms development Easewith secuyourr e,transition cloud-based ac ratoss thescale entire product development instrumentation and software pipeline with access to commercial-use rights, assurance of Ease your transitionsuperiorPipeline ac inputr ossacceleration ma theterials, enti and andPr supporter oductpprovenroduct quality development development assurance at scale pipeline with accessstandaEase ryourdsto transitiontcommeo help across achiever thecial-use entire regula product trights,o developmentry compliance assu pipeliner withance access of to commercial-use Multiplexing at scale rights, assurance of best-input materials,Ease and your proven tr qualityansition standards ac tor achieveoss theregulatory enti compliance.re prPoductroduction development at scale superior input matGibcoerials,™ Cell Therapy and Systems pr ovenpipeline quality with assu accessrCommercialance to supplycomme team rcial-use rights, assurance of Get the most out of your precious samples ™ Drive performance and achieve optimal (CTS ) products • Our experienced team can support you in the commercial standards to help •achieve GMP manufactured r egula tosuperiorry compliance input matdevelopmenterials, ofand molecular pbiop diagnostics,rovenrocessing immunodiagnostics, quality outcomes assu r ancewith our custom Multiplexing at scale CTS products have cell Productiontherapeutics, and at life scalescience products. Partner with us for accuSampleracy and reduced processing variability through at scale and gene therapy–specific the quality, security of supply, customization,services and expertise irrespective ofOutsou batch size rcing at scale Get the most out of your precious samples standardsDrive t ope rhelpformance achieve and achieve regula optimalt ory compliance simultaneous measurements intended use statements, you need to enable the development and commercialization Enhance your productivity and generate superior extensive safety testing, bioprocessing outcomesof your products with ouror services. custom Find out more on page 13. accuracy andoutcomes reduced variability with th advanced-perough rformance, and proactive regulatory services irrespective of batch size experts, and remove barriers of needing to simultaneous measurements documentation for clinical cell high-throughput solutions Data managementtherapy and immunotherapy at scale acquire new skills and instrumentation research and manufacturing. Sample processing at scale Easily manage your data and collaborate with partners Outsourcing at scale Sample pDatarocessing management at at scalescaleInstruments with software that assists Outsourcing at scale across a spectrum of platforms with secure, cloud-based Enhance your productivity and generate Enhancesuperior yourEasily pr manageoductivity your data and and genecollaborrainat e21t withe CFR superior Partpar tners11 compliance Science at scale across a spectrum ofinstrumentation platforms with secu• Softwareandre, cloud-basedsoftwa supports rcompliancee with 21 CFR outcomes with advanced-performance, vs. Part 11 FDA guidelines on electronic records experts, and remove barriers of needing to outcomes withinstrumentation advanced-pe and softwarformance,re security, and prevents unauthorized access experts, and remove barriers of needing to high-throughput solutions high-throughput solutions to the instrument. acquire new skills and instrumentationacquire new skills and instrumentation

Research solutions for biotech companies 11 Science at scale Science at scale vs. vs.

Multiplexing at scale Production at scale Get the most out of your precious samples Drive performance and achieve optimal bioprocessing outcomes with our custom accuracy and reduced variability through services irrespective of batch size simultaneous measurements

Multiplexing at scale Data management at scale Production at scale Easily manage your data and collaborate with partners Get the most out of your preciousac samplesross a spectrum of platforms with secure, cloud-based Drive performance and achieve optimal Multiplexing at scale instrumentation and software Productionbiop ratocessing scale outcomes with our custom Get the most out of your precious samplesaccu racy and reduced variability through Drive performance and achievese optimalrvices irr espective of batch size simultaneous measurements bioprocessing outcomes with our custom accuracy and reduced variability through services irrespective of batch size simultaneous measurements Data management at scale Easily manage your data and collaborate with partners across a spectrum of platforms with secure, cloud-based Data management at scaleinstrumentation and software Easily manage your data and collaborate with partners across a spectrum of platforms with secure, cloud-based instrumentation and software Accelerate your timelines by outsourcing research projects to Thermo Fisher Scientific We provide specialized, reliable, high-quality outsourcing solutions for customers who don’t have the capacity, time, or resources to handle a project in-house.

• Optimize your workflow with new technologies by accessing the expansive technological expertise of the R&D scientists who developed our kits.

• Expedite your research and development by accessing our robust global network of lab spaces engaged in cutting-edge innovation.

• Minimize risk in your pipeline by placing your projects with our team of dedicated scientific project managers that ensure quality and on-track delivery.

We can tailor workflows for all research projects, including: • Vaccines—gene to protein, cell line production, immunoassays, custom peptides, and custom Fast-track your timelines Our dedicated and focused antibody production project management team will help accelerate your time to discovery via a global network of R&D support. • Small molecules—assay and cellular assay

technologies, biochemical and cell-based profiling,

Leverage our loss-of-function screening, genome editing, experience in library screening, drug metabolism and drug safety, lab essentials as Decrease FTE a powerful resource hands-on time oligonucleotides, microarray analysis to augment your Free up your skilled R&D research team—from scientists (and lab space) routine experiments from routine everyday to the most recent tasks, allowing them to • Immunotherapy—immunoassays, custom antibody and innovative focus on strategically techniques. important initiatives. production, custom peptides

Access new • Gene therapy—loss-of-function screening, stem cell technologies and expertise services, genome editing Benefit from connections to unique skill sets and • Cell therapy—stem cell services, cell line specialized resources. Our R&D breakthroughs characterization, genome editing are translated into service offerings that will help you achieve your goals. • Biologics—gene to protein, cell line production, immunoassays, custom peptides, genome editing

• Biomarkers—loss-of-function screening, custom peptides, immunoassays, custom antibody production, transcriptome profiling, genotyping analysis

Find out more at thermofisher.com/customservices

12 Biotech

Enable commercialization with custom manufacturing and commercial supply services As the world’s leading supplier of reagents and instruments for molecular biology, cellular imaging, synthetic biology, and protein sciences, we also offer the most comprehensive technology and product portfolio for use by companies in developing next-generation molecular testing and immunodetection assays. Leverage our superior combination of quality, global distribution, and commercial services and support so you can maximize your efficiency and scale while minimizing risk, and bring your product to market faster.

Accelerate your assay development and kit manufacturing Creating a high-performing, competitively positioned assay is demanding and challenging. We understand this challenge from our work with leading biotech companies who face many of the same difficulties you do. By choosing us, you gain more than just a partner—you’ll have an experienced team committed to your success at every stage of the product development and commercialization process.

Commercial supply capabilities Customization Superior quality Robust security of supply From assay design to workflow Don’t cut corners when it comes to Partnering with us will help ensure the optimization—whatever your needs, quality. Bring your vision into being security of your raw material supply. our custom services team is there for in our state-of-the-art manufacturing We have strong safeguards in place you, including: sites. Your product will be subjected to help you reduce risk and avoid to rigorous testing to ensure lot-to-lot delays and setbacks in manufacturing, • Custom format and formulation with consistency and reproducibility with including: in-process testing the following compliance: • Advanced change control • Custom functional testing • Certified quality systems notifications (e.g., bridging studies, verification with ISO 9001, ISO 13485, testing, stability studies ) and ISO 14001 status • A global manufacturing footprint

• Packaging, labeling, and kit • Six Sigma and Lean • Comprehensive controls over raw production Manufacturing processes materials and processes

• Lyophilization • Manufacturing and filling within • Confidentiality facilities that meet 100,000 (class D) clean room standards

Find out more at thermofisher.com/oem

Research solutions for biotech companies 13

Therapeutics development

Your partner for every step in your therapeutics development journey No other partner to the biotech industry can support the rapid, end-to-end development of a therapeutic like Thermo Fisher Scientific can. From discovery to commercialization, our innovative and flexible tools, scalable solutions, and custom services help accelerate your success.

thermofisher.com/biotechtherapeutics

15 Cell therapy development Your work holds the potential to deliver life-changing treatments. Our mission is to help you succeed by providing high-quality materials, services, and support to help you translate your cell therapy from discovery to clinical research and commercial manufacturing.

Solutions to support gene-modified cell therapy development, every step of the way

Cell culture and Profiling and Wash, fill, finish Cell isolation Cell engineering expansion selection

• Sample prep and • Genome editing • Media, serum, and • Functional analysis • Wash buffers cell isolation supplements • Transfection • Genomic stability • Cryopreservation • Cell activation • Automated cell and safety • Validation • Cryogenic storage (if applicable) counting of genome and logistics Solutions • Evaluation of editing (Sanger • Endotoxin-free, activation sequencing, high-quality and qPCR, dPCR) -yield plasmid purification • RNAi

• Regulatory path • High editing • Higher cell survival • High throughput, • High reliability efficiency, rates speed, and • Processing • Flexibility by accuracy, and automation samples easily, • Flexible culture customization specificity quickly, and conditions • Accuracy accurately with • High transfection • Compatibility walk-away efficiency and We enable with regulatory automation throughput guidelines • ISO manufacturing • High potency standards • Validated protocols

See the full range of CTS solutions at thermofisher.com/celltherapy

16 Therapeutics development

See the full range of CTS products at thermofisher.com/cts

Cell Therapy Systems products: a proven choice for clinical cell therapy manufacturing As you move your research toward the clinic, high-quality products and proper documentation are essential to getting it right the first time. We offer a broad array of high-quality Gibco Cell Therapy Systems (CTS) products designed for use in cell therapy research applications, including media, reagents, enzymes, selection beads, and devices, which are manufactured in conformity with GMP for medical devices, 21 CFR Part 820, following USP<1043> and Ph Eur 5.2.12, at sites that are FDA-registered and ISO 13485–certified and regularly audited.

When you choose CTS products, you can expect:

cGMP-compliant documentation Seamless transition Expert consultation • Traceability documentation from research to clinic • Regional technical support for including Certificates of Analysis, • Defined formulations minimize all CTS products Certificates of Origin, Drug Master lot-to-lot variability Files (DMF), and/or Regulatory • Experienced professionals Support Files (RSF) • Manufactured under scalable to help navigate regulatory cGMP conditions processes from research to • Helps reduce time in preparing commercial phase investigational new drug (IND) • Complementary RUO products submission • Cell therapy expertise to help • Extensive QA testing for sterility, answer all of your questions • All products are ready to be used endotoxins, adventitious agents, as part of your IND (CMC-ready) and mycoplasmas on media and • Backed by more than 50 years • CTS product labeling and intended reagents of Gibco™ media experience use statements

Research solutions for biotech companies 17 Gene therapy development Gene therapy research holds great promise for treating a wide range of diseases that were once thought untreatable. Explore our portfolio of high-quality gene therapy products and services to discover the tools you need to move your project from research to clinical trials and commercial gene therapy manufacturing.

Solutions to support gene therapy development

Vector Vector Vector Profiling and construction production purification selection

• Gene synthesis • Viral vector production* • Chromatography • Immunoassays and services • Cloning and assembly • Host-cell residual DNA • Flow cytometry • Flow cytometry for quantitation • Large-scale • Imaging titer check plasmid purification • Contamination testing Solutions • High-content analysis • Single-use • Nucleic acid and assays technologies and quantification bioreactors for scaled- • Mass spectrometry • Vector verification, up production and assays Sanger sequencing • Specialized laboratory • Western blot analysis equipment • Next-generation • Cell culture plastics sequencing • Automated cell • Microarray analysis counting • Genomic stability and * CTS products and RUO safety testing, qPCR version available.

• Save time and overhead • High yields and • Flexibility of multiple • High throughput, speed, with outsourced specificity purification options to and automation meet specific needs services • Regulatory path • Accuracy We enable • High cloning efficiency • Efficient scale-up • High-yield purification solutions

18 Therapeutics development

Innovations designed to accelerate your development of gene-modified gene therapies

Adeno-associated virus Lentivirus RNA and DNA Our industry-leading and scalable Cost-effective lentiviral vector (LV) therapeutics development solutions for adeno-associated production is critical to meeting Accelerate your nucleic acid– virus (AAV) vector development commercial demand, and a smooth based therapeutic drug discovery, can help you throughout your AAV scale-up to clinical production is development, and commercialization manufacturing process, whether essential. To address these needs, when you partner with the you need equipment, consumables, we have optimized solutions to Thermo Fisher RNA therapeutics CDMO services, or field applications help reduce production costs and supply team. You’ll gain access to support. Additionally, we take great streamline your transition from gene innovative platform technologies, measures to provide assurance of therapy research to clinical scale. technical expertise for RNA supply for our products, to help you therapeutics, manufacturing scale, advance your program from the lab and customized solutions for your through commercial manufacturing. entire workflow from compound synthesis, purification, and analysis to formulation and delivery.

Discover the full range of solutions at thermofisher.com/genetherapy

Research solutions for biotech companies 19 Immunotherapy development With the recent surge of T cell–based immunotherapies, more researchers are taking an interest in these specialized immune cells, particularly with respect to the development of chimeric antigen receptor T cell (CAR T) therapies.

Our solutions are for development research for cell therapy, gene therapy, immune checkpoint inhibitor therapy, and cancer vaccine development.

To find out more, go to thermofisher.com/biotechimmunotx

20 Therapeutics development

Cell-based immunotherapy Whether you’re developing a CAR T therapy, another type of T cell immunotherapy, or working with other immune cell types, we can help you move from research to the clinic and beyond.

Immunotherapy workflow from isolation to characterization We have an extensive selection of high-quality research use products to support your early cell therapy development. As you move toward clinical and commercial applications, our GMP-manufactured Cell Therapy Systems (CTS) products offer specific cell and gene therapy use statements, extensive safety testing, and proactive regulatory documentation.

Cell isolation Cell engineering Cell culture Wash, fill, and finish Characterization and activation and gene transfer Gibco™ CTS™ GMP- Critical-environment and release testing Gibco™ magnetic Plasmid purification, manufactured media containers and fluid Assays for flow beads for clinical transfection reagents, and reagents and transfer solutions cytometry, real-time applications lentiviral transduction, PCR, Luminex® and Invitrogen™ electroporation, and instruments, NGS, Dynabeads™ gene editing tools and more magnetic beads for Research Use Only experiments* Discover the full range of solutions at thermofisher.com/immunotherapy

*The different antibody ratios and clones of the strictly RUO beads vs. beads meant for translational and clinical use can give different activation profiles. Thus, customers using the strictly RUO products should only have a research focus, while customers who want to take their procedure to clinical trials need to use the translational/clinical products to avoid revalidation of all of their assays when going to clinical use.

Research solutions for biotech companies 21 Small molecule development Small molecules are powerful therapeutic weapons that deliver tremendous health outcomes.

Solutions to support small molecule development

Target Assay development Primary Lead Lead Toxicity studies/ discovery and optimization screening generation optimization safety pharmacology

• Genome editing • Genome editing • Fluorescence- • Fluorescence- • In vivo studies • Fluorescence- based assays based assays based assays • SelectScreen™ • RNAi • ADME services • High-content • High-content • High-content • Plasmid • In vitro off-target analysis analysis analysis • Biochemical purification studies Solutions analysis • Flow cytometry • Flow cytometry • Flow cytometry • Transfection • SelectScreen • Nucleic acid • Plate-based • Plate-based services • qPCR gene • Nucleic acid extraction assays assays expression and analysis • Microarray genotyping • Knockout/ • SelectScreen • SelectScreen analysis • High-content assays knockdown services services analysis • Media, sera, • Microarray • Media, sera, • Media, sera, • Microarray supplements, • Flow cytometry analysis supplements, supplements, analysis and plastics and plastics • Plate-based and plastics • Media, sera, • Media, sera, assays supplements, • High-content supplements, and plastics analysis • Microarray and plastics analysis • Flow cytometry • Plate-based assays • Microarray analysis

• Find therapeutic • Accurate and • High throughput, • Assay robust • Assay robust • Compound safe targets biologically automation enough to enough to enough to move relevant determine determine to Phase 1 • Confirm • Assay sensitivity screening model accurate accurate clinical trials therapeutic pharmacology toxicology and targets • Assay is pharmacology We enable discovered automatable by others for efficiency • 21 CFR for GLP compliance 22 Therapeutics development

Hit milestones faster by getting to the data more quickly and easily Rapidly discover and validate Simplify compound hit Confidently validate compound safety new therapeutic targets characterization • Get more physiologically relevant results • Minimize the trial-and-error phase and • Put an end to the slow and complex with Gibco™ 2D and 3D hepatic systems, get to answers faster and with less effort quantitative analysis of cell populations subcellular fractions, and transport systems. with Invitrogen™ Genome Editing Technology and obtain cutting-edge images and data Our team of product specialists is on hand Systems. Designed to work together, these quickly and easily. Thermo Scientific™ to offer support and application knowledge optimized and validated systems are the only high-content screening platforms combine relating to your compound and any DMPK, complete toolset for every step in your cell fluorescence imaging, image processing, ADME, and induction research. engineering workflow. and automated cellular measurements to • Streamline toxicity studies with Applied provide exceptional resolution for high- • Rapidly perform deep and broad Biosystems™ TaqMan ® Assays. Our technology throughput analysis. transcriptome analysis, including coverage is the gold standard of performance, quality, of novel noncoding transcripts and splice • Reduce compound interference by and content for gene expression analysis isoforms, with Applied Biosystems™ applying TR-FRET technology with by real-time PCR, developed using long- Clariom™ D Assays. Even working with Invitrogen™ LanthaScreen™ kinase activity standing bioinformatic expertise in primer and low input RNA from precious or challenging assays. This toolbox of “mix and match” probe design and stringent testing across samples such as FFPE tissue, you save time reagents is designed to enable rapid assay applications and integrated platforms. by moving quickly and confidently from configuration on multiple target classes and • Drive deeper scientific insights into sample to answer. instrument platforms. complex disease susceptibility, • Simplify your sequencing on a broad • Generate expression data for secondary pharmacogenomics, and genetic factors in range of applications with Ion Torrent™ compound library screening and hit diverse populations to advance population next-generation sequencing systems and profiling more quickly and economically genomics studies. The Applied Biosystems™ consumables. The flexible systems allow you to with the Applied Biosystems™ Clariom™ Axiom™ Precision Medicine Diversity Research scale, automate, and operate at a broad range GO Screen Assay. Developed in partnership Array is a comprehensive, imputation-aware of throughput capacities alongside a broad with pharmaceutical industry leaders, genotyping resource with >850,000 markers range of plug-and-play consumables. the 384 format microarray solution selected for high genomic coverage. provides a high-throughput, low-cost method to directly measure the expression of ~20,000 genes.

Discover the full range of solutions at thermofisher.com/biotechmolecules

Research solutions for biotech companies 23 Biologics The expansion of personalized medicine has also had an impact on drugs’ evolutionary timelines. Biologics are advancing swiftly. Partner with us for access to tools that enhance your innovation.

Solutions to support biologics development

Synthesizing Candidate testing Process and analytical Clinical Commercial antibodies and optimization development studies/trials production

• Starting materials • Immunoassays • Bioreactors • Essential • MS-certified vial of antibody plasticware, kits (vials and • Immuno-PCR • Chromatography components, and caps) • Nucleic acid and purification • Mass spectrometry equipment extraction solutions • Sample • Multiplex • Kitting, packaging, preparation Solutions • Protein expression • Bioprocessing immunoassays and private labeling impurity and • HPLC and UHPLC • Stable cell lines • qPCR analysis contamination columns • Western blot testing • Flow cytometry • Reversed-phase analysis • NGS • qPCR analysis HPLC • Cell counting • High-content • Microbial testing • Size exclusion • Imaging chromatography analysis • Mycoplasma • Chromatography • Western blot testing • LC-MS and purification analysis • Adventitious virus • Columns for solutions • Imaging testing mRNA vaccine • Capillary characterization • Endotoxin testing electrophoresis– based human cell • Host-cell residual line authentication DNA quantitation • Phage display • NGS instruments and consumables

• Cost-effective and scalable solutions • Both standard and customizable solutions for a scalable and robust process • Speedily transition from research to the clinic and large-scale production We enable See the full range of solutions at thermofisher.com/biotechbiologics

24 Therapeutics development

Innovations designed to accelerate your development of antibody-based therapies

Cost-effective solutions to increase Reliable solutions to characterize Customizable and scalable solutions productivity and speed and optimize antibody candidates toward commercialization • Obtain customized DNA constructs with 100% • Multiplex up to 65 targets per sample • Scale up your process or product development sequence accuracy with Invitrogen™ GeneArt™ for faster time-to-data with lower sample pipeline with bulk quantities of high- quality Gene Synthesis. consumption with Invitrogen™ ProcartaPlex™ immunoassay reagents and biochemicals. Immunoassays. • Isolate advanced transfection-grade plasmid • Get ultimate flexibility for your most complex DNA in about half the time of current standard • Increase your flow cytometry efficiency processes with Gibco™ custom cell culture protocols with Invitrogen™ PureLink™ Expi and flexibility with the Invitrogen™ Attune™ media that is customized to your research and Endotoxin-Free Plasmid Purification Kits. NxT Flow Cytometer with CytKick™ Max production needs. Autosampler. It is up to 10 times faster, has • Rapidly produce high amounts of protein in • Help reduce risk and improve operational up to 14 colors, doesn’t clog with difficult less time and at a lower cost with Gibco™ efficiencies from lab/scale-up to cGMP samples, and offers walk-away automation. Transient Protein Expression Systems. production applications with Thermo Scientific™ HyPerforma™ Single-Use Bioreactors.

Research solutions for biotech companies 25 Vaccines Vaccines harness the power of the immune system to fight disease. Your vaccine research and development efforts can improve health outcomes and prevent pandemics. The world relies on you to rapidly develop and deploy safe and efficacious vaccines.

Solutions to support every step of your vaccine development journey Our team and products support vaccine research, regardless of approach, enabling the speed and accuracy needed to shorten your development timeline.

Antigen Process and Target Clinical Commercial identification analytical discovery studies/trials production and selection development

• DNase/RNase- Vaccine synthesis Functional • Bioreactors • Materials that free lab bench analysis are designed to • Gene synthesis • Chromatography preparation tools meet regulatory • ELISA and purification (see Molecular • Transient, stable requirements for Solutions solutions diagnostics on cell line for • Multiplex cGMP production page 30) protein-based bead-based • Bioprocessing and QA/QC vaccine immunoassay impurity and testing • Pathogen nucleic (Luminex® contamination acid isolation • In vitro • Logistical and technology) testing by PCR, transcription technical support • Pathogen/host qPCR, NGS and reagent, • Mass genetic analysis Sanger sequencing purification spectrometry by qPCR, Sanger for mRNA- • Microbial testing sequencing, and • Western blot based vaccine • Mycoplasma NGS ™ analysis (TheraPure testing • Pathogen protein reagents) • Flow cytometry • Adventitious structure analysis • High-content • Cell counting virus testing • Mass analysis • Chromatography spectrometry • Endotoxin testing and purification • Imaging (in vitro • Thermal cyclers solutions and in vivo) • Host-cell residual DNA quantitation • Nucleic acid • Nucleic acid • qPCR • Essential quantification extraction and • NGS quantification plasticware, components, • Capillary and equipment electrophoresis– based human • Kitting, packaging, cell line and private labeling authentication

• Speed, accuracy, • Cost-effective • Both standard • Rapid genotyping to stratify trial and support and scalable and customizable participants by immune response solutions solutions for a • Maximize • Provision of global clinical trial support, scalable and screening • Speedily including supply management, robust process throughput of transition from labeling, packaging, and storage, and We enable vaccine targets research to distribution and logistics the clinic and large-scale production

26 Therapeutics development

Progress through the first 3 phases of your journey with speed and accuracy Quickly and accurately identify Characterize and prepare high Build a scalable, robust, and highly antigens that elicit a strong yields of high-quality pathogen controlled process for vaccine immune response components for preclinical testing development for clinical trials Our extensive range of highly sensitive Our wide array of products can be used Our team can help identify materials, products and scalable solutions is to develop various types of vaccines, equipment, analytical methods, and process designed to support you from viral nucleic including live-attenuated, inactivated, conditions to support both standard and acid isolation to pathogen analysis and subunit, and genetic vaccines. Our scalable customizable solutions for a scalable and detection by qPCR, Sanger sequencing, solutions render high quality and high yields robust vaccine development process. and NGS. Our products enable speed of pathogen components needed to build your and accuracy while maximizing screening vaccine while helping you save time and money. thermofisher.com/processanddevelopment input of vaccine targets. thermofisher.com/ thermofisher.com/targetdiscovery antigenidentificationandselection

See the full range of solutions at thermofisher.com/biotechvaccines

Research solutions for biotech companies 27

Diagnostics development

Supporting your success in the development of new diagnostics Your work to develop innovative diagnostics that deliver answers as quickly and precisely as possible can lead to greatly improved health outcomes. Effective tests empower caregivers with the ability to assess risk and identify disease early, monitor the efficacy of treatments, and provide reliable prognoses. We have listened to your feedback, and we know you face myriad challenges on the journey from discovery to commercialization.

Our capabilities to help you navigate these challenges are unmatched. When you partner with Thermo Fisher to help enable development of new diagnostics, your success is our wholehearted purpose.

High-quality Cost-effective Innovative products solutions tools

Support across Scalability as the workflow you grow

thermofisher.com/biotechdiagnostics

29 Molecular diagnostics Take no chances in the effort to achieve your goals in molecular diagnostics. Partner with us for the quality, security of supply, customization, and expertise you can expect from Thermo Fisher Scientific.

Solutions to support molecular diagnostics development

Biomarker Clinical validation, Sample Nucleic acid Biomarker Test identification/ studies/trials, collection isolation verification development discovery production

• Whole-blood • Nuclease-free • Microarray analysis • qPCR • qPCR • qPCR collection tubes lab bench assays and instruments, instruments, instruments, preparation tools instruments assays, and assays, and assays, and • Fractionation, reagents reagents reagents Solutions stabilization, and • Nucleic acid • Cytogenetics kits

extraction kits isolation kits and and reagents • Branched • Cells-to-CT kits • NGS instruments, instrumentation DNA–based targeted • qPCR instruments, • QuantiGene gene expression sequencing • Magnets and assays, and gene expression analysis assays, kits, mixers reagents assays and reagents • Microarray • DNA, mRNA, and • NGS instruments, • NGS instruments, analysis assays, exosome isolation targeted targeted instruments, kits and reagents sequencing sequencing and services assays, kits, assays, kits, • Nucleic acid and reagents • NGS instruments, and reagents quantification targeted instruments • Sanger sequencing sequencing and assays systems assays, kits, and reagents • Cell model creation— Invitrogen™ ™ Cells-to-CT kits, gene synthesis, thermal cyclers, cell culture plastics, transfection reagent, and characterization assays • Cell based analysis— imaging, high-content analysis, and flow cytometry • Protein analysis— immunoassays and western blot analysis

• Compatibility with • Compatibility with • Comprehensive • Highly accurate, • A path to the • A path to the clinically relevant clinically relevant and accurate flexible, and fast clinic with clinic with samples samples coverage for singleplex and IVD-cleared IVD-cleared genomic and multiplex options instruments instruments • Safe, simple • High yields of gene expression sample collection high-quality • Customization of • Assay and analysis We enable nucleic acid solutions to meet instrument • Effective • Robust workflow your specific precision stabilization and • Simple for low-input needs preservation of automation for • Customization and challenging nucleic acid increased sample • A path for of gene panels samples throughput regulatory to meet your • Intuitive, actionable compliance specific test data analysis needs

Discover the full range of solutions at thermofisher.com/biotechdiagnostics

30 Diagnostics development

Business models supporting each step of your business evolution You will face challenges on your product development journey. Work with our commercial supply team and they will help you to overcome them so you can focus on your technology with confidence. With our four state-of-the-art technology platforms for next-generation sequencing (NGS) and Sanger sequencing, and PCR and real-time PCR, we’ve helped our partners launch tests in a wide range of molecular applications, such as infectious diseases, animal health, reproductive health, and oncology. No matter what your application, throughput, turnaround time, or cost-per-sample needs, you can count on us to help you access the best reagents and instruments for your focus area.

Instrumentation Consumables Services • Instrument placements • OEM reagents and plastics for kits • Custom manufacturing or services • Reagent rentals • Lyophilization and kitting services • Bulk, custom, or private-label • Private labels • Assay development and optimization services components • Leverage our global install base • Licensing to exclusive IP of instruments

Research solutions for biotech companies 31

Solutions for service providers

Your ability to provide research, manufacturing, or testing services to your clients depends on your ability to meet their needs on time, in scope, and within budget. Your customer’s timeline is essentially your own; so with your contract as your promise, you need to be confident that you can deliver on every commitment, every day.

Thermo Fisher can add advantages like:

cGMP-compliant manufacturing facilities to meet your regulatory and safety needs

Flexible and cost-effective solutions designed to consistently deliver high-quality results, quickly

Scalable solutions that automate processes to save you time and resources

An unrivaled breadth of products and services to meet your needs

A legacy of experience and know-how to help build you the optimal workflow

Support, guidance, or help meeting any challenge you might face

No other industry partner can offer this full range of robust solutions. thermofisher.com/biotechservices

33 Contract research organizations Helping you meet your commitments every time The support you provide to the pharmaceutical, biotech, and medical device industries is invaluable. Whether you’re delivering preclinical, toxicology, laboratory analysis or biostatistics, clinical trials, dealer management systems, or quality assurance services, we have the unrivaled breadth of tools and expertise you need to confront any challenge head on.

Ultimate flexibility for your most complex processes Your needs are unique, so we have a range of custom solutions across your workflow, including: • Custom cell culture media • Custom NGS panels for targeted sequencing

• Custom real-time PCR assays and master mixes • Custom peptides

• Custom antibodies and immunoassays • Custom DNA oligos

• Custom gene synthesis

34 Solutions for service providers

Contract development and manufacturing organizations Enabling you to be a single source for your customers With your efforts to provide comprehensive services to pharmaceutical companies, from drug development through manufacturing, we understand you need to ensure regulatory compliance, efficiency, and quality in every process.

With Thermo Fisher as your partner, your customers can be confident that you’re leveraging the latest scientific insights, top-notch materials, trusted experts, and cutting-edge technology to ensure the safety and efficacy of their product.

Helping to ensure the availability and quality of your products From manufacturing to delivery, we are focused on ensuring assurance of supply. We do this by forecasting customer demand so manufacturing produces enough, protecting your products during shipping so they arrive as they should, and drawing on our extensive network of manufacturing and distribution sites so you receive your products when you need them.

Robust Reliable Consistent Supply chain network distribution product supply excellence We have multiple manufacturing We preserve product quality We do everything to permit We ensure our supply chain is a and distribution sites to help right up to your door. efficient forecasting and planning competitive advantage, which our ensure your product supply. to manage product availability. customers benefit from when they • Product held close to our select us as a business partner. • A network of 85 global customers to minimize traveling • Extensive customer manufacturing sites and distance demand forecasting defines • Continually strive to achieve 110 distribution locations manufacturing quantities to process efficiencies that • Products are securely packaged enable product availability positively impact our service • Extensive collaboration across to protect them when moving and exceed customer the network to help ensure we at speed • Collaborative planning expectations deliver on your requirements across the network to ensure • Specialist carriers used where availability • Use real-time data to monitor required our delivery to customers and • Availability to promise on • Expertise in cold chain logistics make improvements customer orders, both pre- and post-order • Use advanced analytics to determine the required inventory investment

Research solutions for biotech companies 35 Services and support for instruments

Because science can’t wait

There’s no time for downtime in your lab. Built on more than 35 years of service expertise, our superior services and support solutions and applications help keep your lab up and running. More than 1,400 trained professionals make up the industry’s largest network, ready to assist you when you need it. And smart features such as remote instrument services help keep you productive and focused on making the next discovery.

Learn more at thermofisher.com/instrumentservices

36 Services and support for instruments

Service plans Analytical validation Maximize system uptime, reduce repair costs and consulting services turnaround time, extend the life of your instrument, Inefficient or ineffective analytical validation (AV) can be and help keep it running at peak performance with one risky to a laboratory business, with substantial delays to of our comprehensive service plans. Instruments covered test enablement costing a loss of reimbursement revenue. by our on-site plans are prioritized in the repair queue, Our analytical validation consulting services use industry resulting in a 2x faster response time. Choose from standard practices to accelerate the process to testing a variety of service options that balance your budget, samples, reducing the overall cost burden of validation, productivity, uptime, and regulatory requirements. and providing objective evidence of the test performance Explore service plans for your instrument at for compliance. Let us handle the project management thermofisher.com/instrumentplans of your lab’s AV, and your lab will successfully implement a new test up to 75% faster than by doing it yourself. Get your instrument up and running 2x faster with our on-site service plans Get a complete list of assays and panels we support or contact an AV consulting services specialist at thermofisher.com/av

2x faster Save on Proactive Easier instrument response time repairs insrtrument care qualification Computer system validation Because there’s simply no time for instrument downtime Storing electronic records? Does your laboratory operate Our instrument service plans include digital innovations to GxP, CLIA, ISO, or other global regulations? If so, that help keep your instruments and your lab running you may need to validate your computerized systems. smoothly. With pioneering on-demand tools and capabilities Our computer system validation consulting service can such as remote support using mobile augmented-reality (AR) enable you to meet global regulatory requirements for technology, instrument-driven support, and on-demand data integrity and help you reduce your compliance risk. instrument training, we’re constantly looking ahead so your Our validation professionals—working closely with your lab never falls behind. staff as validation project managers—can help you get into production faster, at the same time also allowing you Learn more about our digital service innovations at to control validation costs and manage your compliance thermofisher.com/innovations risk with industry-accepted validation documentation.

Not sure about your instrument’s coverage status? Learn more about validating your systems when you visit Look up your instrument’s service history instantly thermofisher.com/csv when you visit thermofisher.com/manage

Instrument hardware Education services qualification services Help your team gain new skills or get up and running on Receive reliable, audit-style documentation to help you new instruments, faster. We offer a combination of virtual meet regulatory requirements and industry standards. and in-person classroom instruction, and hands-on learning Our manufacturer-trained and certified field service in your lab to match your schedule, budget, and learning engineers will conduct comprehensive testing of preferences. Whichever course style you choose, you’ll learn your instruments using verified tests, certified tools, from one of our 300 highly skilled applications scientists and developed standards to verify and document who are available to lead sessions online, at your location, instrument performance. or at one of our 12 global training centers.

Learn more or contact an instrument qualifications Explore courses at thermofisher.com/educationservices specialist at thermofisher.com/iqoqpq Research solutions for biotech companies 37 Jump Start for Biotech: New Lab Program Jump Start for Biotech is a free program created to get your new lab up and running with leading-edge products organized by therapeutic and diagnostic development workflows. Gain access to discounts and resources to leverage as you develop ground-breaking therapeutics and diagnostics.

Specialized products for end-to-end therapeutic and diagnostic development The program includes resources You are eligible for the free designed for biotech companies: program if you are: • Webinars • Opening a new lab within your institution or company • Brochures and checklists • Moving your lab to a new space • Learning centers • Starting a new company • Special discounts • Directed to the program by your sales representative

Find out more at thermofisher.com/biotechjumpstart

38 Resources

Resources

Biotech resources: Services including custom manufacturing, thermofisher.com/biotech consulting, and instrument services: thermofisher.com/services Jump Start for Biotech New Lab Program: thermofisher.com/biotechjumpstart Life in the Lab industry magazine: thermofisher.com/litl Laboratory essential products: thermofisher.com/biotechessentials Cancer research resources: thermofisher.com/cancerresearch Coronavirus SARS-CoV-2 (COVID-19) research solutions: Product documentation: thermofisher.com/coronavirus thermofisher.com/support

On-demand learning: thermofisher.com/connect2science

Research solutions for biotech companies 39 Find out more at thermofisher.com/biotech

For Research Use Only. Not for use in diagnostic procedures. © 2020 Thermo Fisher Scientific Inc. All rights reserved. All trademarks are the property of Thermo Fisher Scientific and its subsidiaries unless otherwise specified. Luminex is a trademark of Luminex Corp. TaqMan is a registered trademark of Roche Molecular Systems, Inc., used under permission and license. COL012879 1120