Cracking the Code: the Economic Impact of San Diego's Genomics

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HOW SAN DIEGO STACKS UP UNDERWRITTEN BY The genomics scorecard uses innovation, talent and growth metrics to compare the top ten life sciences U.S. metros with illumina populations over one million. San Diego’s composite score ranks it as the number two genomics market in the nation. RESEARCH SUPPORT BY

#9 Minneapolis Boston SPONSORED BY CRACKING #1

#10 Chicago #6 Philadelphia #5 Salt Lake City #8 Indianapolis THE CODE: #3 San Francisco THE ECONOMIC IMPACT OF Raleigh #4 San Jose #7 SAN DIEGO’S #2 SAN DIEGO GENOMICS INDUSTRY

SAN DIEGO RANKS INNOVATION TALENT GROWTH #2 #2 #4 INNOVATION TALENT GROWTH PATENT INTENSITY, GRADUATE PIPELINE, UNIQUE JOB FEDERAL FUNDING, TRANSFERABLE POSTINGS, FIVE-YEAR VENTURE CAPITAL SKILLS, OCCUPATIONAL INVESTMENT OCCUPATIONAL GROWTH, PROJECTED CONCENTRATION OCCUPATIONAL GROWTH

INDUSTRY VOICES

One thing you immediately discover when you come to San Diego is this collaboration not seen anywhere else; it’s“ collaboration to combine the parts and pieces across industries, make sense of the data and apply it to solve problems.” Dawn Barry, Vice President, Applied Genomics, Illumina For a copy of the complete study, visit Boston has the pharmaceutical industry and the Bay Area sandiegobusiness.org/research PRODUCED BY has Silicon Valley, but San Diego is where the fundamental For an expanded, interactive version of the timeline, research that drives precision medicine is happening. “ visit GenomicsSD.org Here, genomics has its own identity.” Dr. Jorge Garces, President & CEO, AltheaDx Released in June 2017 EXECUTIVE SUMMARY

GenomicsSD.org

For the full version, visit version, full the For

Sequencing (NGS) increases output 70x output increases (NGS) Sequencing method shotgun using genome launched is Foundation Research testing prenatal DNA-based $120M grant for large-scale genomics study study genomics large-scale for grant $120M Scientific Fisher Thermo by

Introduction of Next Generation Generation Next of Introduction sequences Venter Craig Novartis the of Institute Genomics pioneering founded, is Sequenom awarded is Institute Research Scripps The acquired is Technologies Life

1999 1994 2016 2013 2007 2003

Michael Heltzen Michael

CEO, BlueSEQ CEO, ,

and wellness.” wellness.” and

health drive to data genetic

“

how we are using our personal personal our using are we how

milestone won’t just be about genomics, but but genomics, about be just won’t

Orange indicates a San Diego Diego San a indicates

technologies sequencing gene of era analysis technology into the cloud the into technology analysis $1K below falls genome Technologies Life form to combine Genomics Synthetic completed is Project

Five years from now the discussion discussion the now from years Five

GENOMICS

new a launching founded, is Illumina Edico Genome takes rapid genome genome rapid takes Genome Edico a sequence to Cost Biosystems Applied and Invitrogen co-founds Venter Craig Genome Human The

2005 2003 1998 THE FUTURE THE 2017 2014 2008 A HISTORY OF OF HISTORY A

INSTITUTES WITHIN INDUSTRY WITHIN

IT DEPENDS IT IMPORTANT ALL AT NOT

RESEARCH FIRMS OTHER

IMPORTANT SOMEWHAT IMPORTANT VERY

DATA-DRIVEN HEALTH SOLUTIONS HEALTH DATA-DRIVEN

MFG

100 80 60 40 20 0

OF IMPORTANCE INCREASED THE PHARMACEUTICAL

DATA ANALYTICS; AN INDICATOR OF OF INDICATOR AN ANALYTICS; DATA

78% 80%

54%

DO BUSINESS DO SKILLS SUCH AS PROGRAMMING AND AND PROGRAMMING AS SUCH SKILLS

industries.

TO PLACE EXCELLENT OR GOOD A FOR CANDIDATES TO HAVE SOFTWARE SOFTWARE HAVE TO CANDIDATES FOR A graduate degree graduate A

drawing from multiple multiple from drawing

EITHER AS DIEGO SAN RATE FIRMS OF OF FIRMS SAY IT IS VERY IMPORTANT IMPORTANT VERY IS IT SAY FIRMS OF

interdisciplinary field field interdisciplinary MFG

61%

instructions, is an an is instructions, 88% 55%

DEVICE HEALTH IT HEALTH

complete set of genetic genetic of set complete SUPPLIERS

CUSTOMERS BIOMEDICAL 1+ year of industry experience industry of year 1+

of genomes, an organism’s organism’s an genomes, of

The study of the function function the of study The

78%

GENOMICS

to recruit advanced degree holders. degree advanced recruit to

A four-year degree four-year A

Chrisa Mott Chrisa , Head of Human Resources, Human Longevity, Inc. Longevity, Human Resources, Human of Head ,

84% 74%

likely more are industry genomics the

86%

“

San Diego’s genomics industry is amazing.” amazing.” is industry genomics Diego’s San

R&D in employers Additionally, experience.

Technical training Technical

BIOTECHNOLOGY we all succeed; the collaboration within collaboration the succeed; all we

technical training and work-related work-related and training technical

EDUCATION AND EXPERIENCE MATTER EXPERIENCE AND EDUCATION

There’s a mindset here that if one of us succeeds, us of one if that here mindset a There’s

with candidates value Companies

SAYS: SURVEY SATISFIED WITH ACCESS TO... ACCESS WITH SATISFIED

ARE FIRMS LOCAL

A COLLABORATIVE BUSINESS CLIMATE BUSINESS COLLABORATIVE A EMPLOYERS SEEK SPECIALIZED SKILLS AND TRAINING AND SKILLS SPECIALIZED SEEK EMPLOYERS

MAPPING THE GENOMICS INDUSTRY GENOMICS THE MAPPING SAYS: SURVEY

SUPPORTED ELSEWHERE IN THE ECONOMY THE IN ELSEWHERE SUPPORTED

GENOMICS MARKET IN THE U.S. U.S. THE IN MARKET GENOMICS

THE GENOMICS INDUSTRY, ANOTHER 2.5 ARE ARE 2.5 ANOTHER INDUSTRY, GENOMICS THE

* MEASURED PER 10K JOBS 10K PER MEASURED *

INTENSIVE PATENT MOST THE IS DIEGO SAN 1

Epigenomics at UC San Diego San UC at Epigenomics

FOR EVERY DIRECT JOB IN IN JOB DIRECT EVERY FOR MULTIPLIER: JOB

REGION* U.S. OTHER ANY THAN TALENT

. Bing Ren Bing . Dr Center for for Center Director, , 3.5

SAN DIEGO UNIVERSITIES GRADUATE MORE GENOMICS MORE GRADUATE UNIVERSITIES DIEGO SAN

inventiveness of entrepreneurs.” of inventiveness

2014–2016

2016

work of researchers and the the and researchers of work

PATENTS IN GENOMICS IN PATENTS VC RECEIVED VC

interdisciplinary field of genomics. of field interdisciplinary of government, the hard hard the government, of

JOBS 371

$292M

because of the initial investment investment initial the of because GENOMICS OCCUPATIONS GENOMICS CONFERRED DEGREES IN 2016 IN pioneer discoveries across the the across discoveries pioneer DIRECT

10K+ genomics ecosystem is successful successful is ecosystem genomics

KEY IN U.S. THAN GENOMICS-RELATED POSTINGS JOB

and universities will continue to to continue will universities and

impacts are huge. San Diego’s Diego’s San huge. are impacts CONCENTRATED MORE GENOMICS-RELATED UNIQUE ANNUAL AVERAGE

companies, research institutes institutes research companies,

3.1X 2,939 1,968

IMPACT projects succeed, the economic economic the succeed, projects

“

Diego’s San technology,

ECONOMIC Even if only a fraction of of fraction a only if Even

$5.6B

personalized medicine and and medicine personalized of stimulating new discoveries. discoveries. new stimulating of

As we enter into an era of of era an into enter we As Government is in the business business the in is Government

2016 FIRMS

received nearly a quarter of all genomics VC in the U.S. the in VC genomics all of quarter a nearly received 115+ FEDERAL FUNDING FEDERAL

discovery across the globe. the across discovery

$38M genomics-related venture capital. In 2016, San Diego San 2016, In capital. venture genomics-related

that has galvanized scientific scientific galvanized has that

which allows the region to command a large share of of share large a command to region the allows which a fundamental ingredient for a healthy ecosystem. healthy a for ingredient fundamental a

fundamental genomic research research genomic fundamental

intellectual property and strong life sciences companies, companies, sciences life strong and property intellectual reasons the region has a higher-than-average concentration of genomics talent; genomics of concentration higher-than-average a has region the reasons

The region has provided the the provided has region The

San Diego has an exceptional track record for creating creating for record track exceptional an has Diego San

institutions. San Diego’s quality of life and abundant job opportunities are among the top top the among are opportunities job abundant and life of quality Diego’s San institutions. EPICENTER OF GENOMICS GENOMICS OF EPICENTER

The genomics industry benefits from the talent graduating from the region’s top academic academic top region’s the from graduating talent the from benefits industry genomics The FUNDING THE FUTURE THE FUNDING

WHY SAN DIEGO? SAN WHY LIFE CHANGING TALENT CHANGING LIFE SAN DIEGO IS THE THE IS DIEGO SAN

GenomicsSD.org

For the full version, visit version, full the For

1999 1994 2016 2013 2007 2003

Michael Heltzen Michael

CEO, BlueSEQ CEO, ,

and wellness.” wellness.” and

health drive to data genetic

“

how we are using our personal personal our using are we how

milestone won’t just be about genomics, but but genomics, about be just won’t

Orange indicates a San Diego Diego San a indicates

technologies sequencing gene of era analysis technology into the cloud the into technology analysis $1K below falls genome Technologies Life form to combine Genomics Synthetic completed is Project

Five years from now the discussion discussion the now from years Five

GENOMICS

new a launching founded, is Illumina Edico Genome takes rapid genome genome rapid takes Genome Edico a sequence to Cost Biosystems Applied and Invitrogen co-founds Venter Craig Genome Human The

2005 2003 1998 THE FUTURE THE 2017 2014 2008 A HISTORY OF OF HISTORY A

INSTITUTES WITHIN INDUSTRY WITHIN

IT DEPENDS IT IMPORTANT ALL AT NOT

RESEARCH FIRMS OTHER

IMPORTANT SOMEWHAT IMPORTANT VERY

DATA-DRIVEN HEALTH SOLUTIONS HEALTH DATA-DRIVEN

MFG

100 80 60 40 20 0

OF IMPORTANCE INCREASED THE PHARMACEUTICAL

DATA ANALYTICS; AN INDICATOR OF OF INDICATOR AN ANALYTICS; DATA

78% 80%

54%

DO BUSINESS DO SKILLS SUCH AS PROGRAMMING AND AND PROGRAMMING AS SUCH SKILLS

industries.

TO PLACE EXCELLENT OR GOOD A FOR CANDIDATES TO HAVE SOFTWARE SOFTWARE HAVE TO CANDIDATES FOR A graduate degree graduate A

drawing from multiple multiple from drawing

EITHER AS DIEGO SAN RATE FIRMS OF OF FIRMS SAY IT IS VERY IMPORTANT IMPORTANT VERY IS IT SAY FIRMS OF

interdisciplinary field field interdisciplinary MFG

61%

instructions, is an an is instructions, 88% 55%

DEVICE HEALTH IT HEALTH

complete set of genetic genetic of set complete SUPPLIERS

CUSTOMERS BIOMEDICAL 1+ year of industry experience industry of year 1+

of genomes, an organism’s organism’s an genomes, of

The study of the function function the of study The

78%

GENOMICS

to recruit advanced degree holders. degree advanced recruit to

A four-year degree four-year A

Chrisa Mott Chrisa , Head of Human Resources, Human Longevity, Inc. Longevity, Human Resources, Human of Head ,

84% 74%

likely more are industry genomics the

86%

“

San Diego’s genomics industry is amazing.” amazing.” is industry genomics Diego’s San

R&D in employers Additionally, experience.

Technical training Technical

BIOTECHNOLOGY we all succeed; the collaboration within collaboration the succeed; all we

technical training and work-related work-related and training technical

EDUCATION AND EXPERIENCE MATTER EXPERIENCE AND EDUCATION

There’s a mindset here that if one of us succeeds, us of one if that here mindset a There’s

with candidates value Companies

SAYS: SURVEY SATISFIED WITH ACCESS TO... ACCESS WITH SATISFIED

ARE FIRMS LOCAL

A COLLABORATIVE BUSINESS CLIMATE BUSINESS COLLABORATIVE A EMPLOYERS SEEK SPECIALIZED SKILLS AND TRAINING AND SKILLS SPECIALIZED SEEK EMPLOYERS

MAPPING THE GENOMICS INDUSTRY GENOMICS THE MAPPING SAYS: SURVEY

SUPPORTED ELSEWHERE IN THE ECONOMY THE IN ELSEWHERE SUPPORTED

GENOMICS MARKET IN THE U.S. U.S. THE IN MARKET GENOMICS

THE GENOMICS INDUSTRY, ANOTHER 2.5 ARE ARE 2.5 ANOTHER INDUSTRY, GENOMICS THE

* MEASURED PER 10K JOBS 10K PER MEASURED *

INTENSIVE PATENT MOST THE IS DIEGO SAN 1

Epigenomics at UC San Diego San UC at Epigenomics

FOR EVERY DIRECT JOB IN IN JOB DIRECT EVERY FOR MULTIPLIER: JOB

REGION* U.S. OTHER ANY THAN TALENT

. Bing Ren Bing . Dr Center for for Center Director, , 3.5

SAN DIEGO UNIVERSITIES GRADUATE MORE GENOMICS MORE GRADUATE UNIVERSITIES DIEGO SAN

inventiveness of entrepreneurs.” of inventiveness

2014–2016

2016

work of researchers and the the and researchers of work

PATENTS IN GENOMICS IN PATENTS VC RECEIVED VC

interdisciplinary field of genomics. of field interdisciplinary of government, the hard hard the government, of

JOBS 371

$292M

because of the initial investment investment initial the of because GENOMICS OCCUPATIONS GENOMICS CONFERRED DEGREES IN 2016 IN pioneer discoveries across the the across discoveries pioneer DIRECT

10K+ genomics ecosystem is successful successful is ecosystem genomics

KEY IN U.S. THAN GENOMICS-RELATED POSTINGS JOB

and universities will continue to to continue will universities and

impacts are huge. San Diego’s Diego’s San huge. are impacts CONCENTRATED MORE GENOMICS-RELATED UNIQUE ANNUAL AVERAGE

companies, research institutes institutes research companies,

3.1X 2,939 1,968

IMPACT projects succeed, the economic economic the succeed, projects

“

Diego’s San technology,

ECONOMIC Even if only a fraction of of fraction a only if Even

$5.6B

personalized medicine and and medicine personalized of stimulating new discoveries. discoveries. new stimulating of

As we enter into an era of of era an into enter we As Government is in the business business the in is Government

2016 FIRMS

received nearly a quarter of all genomics VC in the U.S. the in VC genomics all of quarter a nearly received 115+ FEDERAL FUNDING FEDERAL

discovery across the globe. the across discovery

$38M

genomics-related venture capital. In 2016, San Diego San 2016, In capital. venture genomics-related

that has galvanized scientific scientific galvanized has that

which allows the region to command a large share of of share large a command to region the allows which a fundamental ingredient for a healthy ecosystem. healthy a for ingredient fundamental a

fundamental genomic research research genomic fundamental

The region has provided the the provided has region The

San Diego has an exceptional track record for creating creating for record track exceptional an has Diego San

WHY SAN DIEGO? SAN WHY LIFE CHANGING TALENT CHANGING LIFE SAN DIEGO IS THE THE IS DIEGO SAN

GenomicsSD.org

For the full version, visit version, full the For

1999 1994 2016 2013 2007 2003

Michael Heltzen Michael

CEO, BlueSEQ CEO, ,

and wellness.” wellness.” and

health drive to data genetic

“

how we are using our personal personal our using are we how

milestone won’t just be about genomics, but but genomics, about be just won’t

Orange indicates a San Diego Diego San a indicates

technologies sequencing gene of era analysis technology into the cloud the into technology analysis $1K below falls genome Technologies Life form to combine Genomics Synthetic completed is Project

Five years from now the discussion discussion the now from years Five

GENOMICS

new a launching founded, is Illumina Edico Genome takes rapid genome genome rapid takes Genome Edico a sequence to Cost Biosystems Applied and Invitrogen co-founds Venter Craig Genome Human The

2005 2003 1998 THE FUTURE THE 2017 2014 2008 A HISTORY OF OF HISTORY A

INSTITUTES WITHIN INDUSTRY WITHIN

IT DEPENDS IT IMPORTANT ALL AT NOT

RESEARCH FIRMS OTHER

IMPORTANT SOMEWHAT IMPORTANT VERY

DATA-DRIVEN HEALTH SOLUTIONS HEALTH DATA-DRIVEN

MFG

100 80 60 40 20 0

OF IMPORTANCE INCREASED THE PHARMACEUTICAL

DATA ANALYTICS; AN INDICATOR OF OF INDICATOR AN ANALYTICS; DATA

78% 80%

54%

DO BUSINESS DO SKILLS SUCH AS PROGRAMMING AND AND PROGRAMMING AS SUCH SKILLS

industries.

TO PLACE EXCELLENT OR GOOD A FOR CANDIDATES TO HAVE SOFTWARE SOFTWARE HAVE TO CANDIDATES FOR A graduate degree graduate A

drawing from multiple multiple from drawing

EITHER AS DIEGO SAN RATE FIRMS OF OF FIRMS SAY IT IS VERY IMPORTANT IMPORTANT VERY IS IT SAY FIRMS OF

interdisciplinary field field interdisciplinary MFG

61%

instructions, is an an is instructions, 88% 55%

DEVICE HEALTH IT HEALTH

complete set of genetic genetic of set complete SUPPLIERS

CUSTOMERS BIOMEDICAL 1+ year of industry experience industry of year 1+

of genomes, an organism’s organism’s an genomes, of

The study of the function function the of study The

78%

GENOMICS

to recruit advanced degree holders. degree advanced recruit to

A four-year degree four-year A

Chrisa Mott Chrisa , Head of Human Resources, Human Longevity, Inc. Longevity, Human Resources, Human of Head ,

84% 74%

likely more are industry genomics the

86%

“

San Diego’s genomics industry is amazing.” amazing.” is industry genomics Diego’s San

R&D in employers Additionally, experience.

Technical training Technical

BIOTECHNOLOGY we all succeed; the collaboration within collaboration the succeed; all we

technical training and work-related work-related and training technical

EDUCATION AND EXPERIENCE MATTER EXPERIENCE AND EDUCATION

There’s a mindset here that if one of us succeeds, us of one if that here mindset a There’s

with candidates value Companies

SAYS: SURVEY SATISFIED WITH ACCESS TO... ACCESS WITH SATISFIED

ARE FIRMS LOCAL

A COLLABORATIVE BUSINESS CLIMATE BUSINESS COLLABORATIVE A EMPLOYERS SEEK SPECIALIZED SKILLS AND TRAINING AND SKILLS SPECIALIZED SEEK EMPLOYERS

MAPPING THE GENOMICS INDUSTRY GENOMICS THE MAPPING SAYS: SURVEY

SUPPORTED ELSEWHERE IN THE ECONOMY THE IN ELSEWHERE SUPPORTED

GENOMICS MARKET IN THE U.S. U.S. THE IN MARKET GENOMICS

THE GENOMICS INDUSTRY, ANOTHER 2.5 ARE ARE 2.5 ANOTHER INDUSTRY, GENOMICS THE

* MEASURED PER 10K JOBS 10K PER MEASURED *

INTENSIVE PATENT MOST THE IS DIEGO SAN 1

Epigenomics at UC San Diego San UC at Epigenomics

FOR EVERY DIRECT JOB IN IN JOB DIRECT EVERY FOR MULTIPLIER: JOB

REGION* U.S. OTHER ANY THAN TALENT

. Bing Ren Bing . Dr Center for for Center Director, , 3.5

SAN DIEGO UNIVERSITIES GRADUATE MORE GENOMICS MORE GRADUATE UNIVERSITIES DIEGO SAN

inventiveness of entrepreneurs.” of inventiveness

2014–2016

2016

work of researchers and the the and researchers of work

PATENTS IN GENOMICS IN PATENTS VC RECEIVED VC

interdisciplinary field of genomics. of field interdisciplinary of government, the hard hard the government, of

JOBS 371

$292M

because of the initial investment investment initial the of because GENOMICS OCCUPATIONS GENOMICS CONFERRED DEGREES IN 2016 IN pioneer discoveries across the the across discoveries pioneer DIRECT

10K+ genomics ecosystem is successful successful is ecosystem genomics

KEY IN U.S. THAN GENOMICS-RELATED POSTINGS JOB

and universities will continue to to continue will universities and

impacts are huge. San Diego’s Diego’s San huge. are impacts CONCENTRATED MORE GENOMICS-RELATED UNIQUE ANNUAL AVERAGE

companies, research institutes institutes research companies,

3.1X 2,939 1,968

IMPACT projects succeed, the economic economic the succeed, projects

“

Diego’s San technology,

ECONOMIC Even if only a fraction of of fraction a only if Even

$5.6B

personalized medicine and and medicine personalized of stimulating new discoveries. discoveries. new stimulating of

As we enter into an era of of era an into enter we As Government is in the business business the in is Government

2016 FIRMS

received nearly a quarter of all genomics VC in the U.S. the in VC genomics all of quarter a nearly received 115+ FEDERAL FUNDING FEDERAL

discovery across the globe. the across discovery

$38M

genomics-related venture capital. In 2016, San Diego San 2016, In capital. venture genomics-related

that has galvanized scientific scientific galvanized has that

which allows the region to command a large share of of share large a command to region the allows which a fundamental ingredient for a healthy ecosystem. healthy a for ingredient fundamental a

fundamental genomic research research genomic fundamental

The region has provided the the provided has region The

San Diego has an exceptional track record for creating creating for record track exceptional an has Diego San

WHY SAN DIEGO? SAN WHY LIFE CHANGING TALENT CHANGING LIFE SAN DIEGO IS THE THE IS DIEGO SAN HOW SAN DIEGO STACKS UP UNDERWRITTEN BY The genomics scorecard uses innovation, talent and growth metrics to compare the top ten life sciences U.S. metros with illumina populations over one million. San Diego’s composite score ranks it as the number two genomics market in the nation. RESEARCH SUPPORT BY

#9 Minneapolis Boston SPONSORED BY CRACKING #1

#10 Chicago #6 Philadelphia #5 Salt Lake City #8 Indianapolis THE CODE: #3 San Francisco THE ECONOMIC IMPACT OF Raleigh #4 San Jose #7 SAN DIEGO’S #2 SAN DIEGO GENOMICS INDUSTRY

INDUSTRY VOICES

#9 Minneapolis Boston SPONSORED BY CRACKING #1

#10 Chicago #6 Philadelphia #5 Salt Lake City #8 Indianapolis THE CODE: #3 San Francisco THE ECONOMIC IMPACT OF Raleigh #4 San Jose #7 SAN DIEGO’S #2 SAN DIEGO GENOMICS INDUSTRY

INDUSTRY VOICES