ANNUAL REPORT 2009 1

FACES OF DISCOVERY 2About the American Federation OUR VISION FOR SHAPING THE FUTURE 3 for Aging Research Cultivating the Champions of Discovery

THE CUTTING- FOCUS NOW AFAR EDGE OF ON AGING IS THE $ DISCOVERY RESEARCH TIME

FUNDING PROMISING AGING GERO- HEALTH PARTNERS SCIENTIST RESEARCH PHYSICIAN SPAN

AFAR’s Mission AFAR’s Research Focus AFAR’s Key Initiatives Aging research unravels the ways LOGICAL DIS RO ORD EU ER The American Federation for Aging AFAR provides financial support AFAR focuses its activities on these N in which we lose resilience and

Research (AFAR) is a non-profit to early and mid-career scientists major initiatives: become susceptible to disease as

organization whose mission is to whose research can increase

• Identifying and funding a broad we age. Understanding the underlying

support and advance healthy aging knowledge of the fundamental

range of cutting-edge research most

through biomedical research. mechanisms of aging. In turn, S C mechanisms of aging is the most E A likely to increase knowledge about T N E this unveils important insights into C B direct way of enabling researchers to healthy aging. E A the disease pathways involved I R D

tackle common diseases of old age,

in many of the chronic problems • Attracting more physicians to

AGING

associated with aging, such as specialize in geriatric medicine RESEARCH such as Alzheimer’s disease, heart

diabetes, heart disease, cancer, to meet the demands of an aging

disease and some forms of cancer. We

dementia and neurological dis- population with expert health care.

are not talking about a “cure” for aging.

orders. Strengthening its mission

• Creating opportunities for scientists

of scientific cultivation, AFAR is Rather, we are talking about finding ways

and clinicians to share knowledge and

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dedicated to training the next

A

D to promote healthier aging in old people.

exchange ideas to drive innovation in E

E S

M

generation of leaders in the field. I D

E

N

T

aging research. T

R If we are successful in doing this, people I

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Since its founding in 1981, AFAR, • Providing information to the public will be healthier longer, reducing the in partnership with foundations, on new medical findings that can help devastating toll of being old and sick. corporations, individuals and people live longer lives, and be less the National Institute on Aging, susceptible to disease and disability. has awarded approximately $124 million to nearly 2,600 talented researchers as part of a broad- based series of grant programs. Terrie Fox Wetle, PhD George M. Martin, MD Roger McCarter, PhD AFAR President and AFAR Scientific Director and Professor of Biobehavioral Health Associate Dean of Medicine for Professor of Pathology, Adjunct Pennsylvania State University For more information on AFAR, Public Health, and Public Policy Professor of Genetics; Emeritus please visit www.afar.org Brown University Director, Alzheimer ’s Disease Research Center University of Washington This annual report is dedicated to Diana Jacobs Kalman. SEE PAGE 19. School of Medicine 4SUPPORTING THE INNOVATORS THE 2009 AFAR GRANT PROGRAMS 5 Building the Aging Research Field

Grants Programs

Since 1981, AFAR has striven to fulfill its mission of supporting and AFAR Research Grants “A cornerstone of our medicine programming is the advancing healthy aging through biomedical research. We are proud of AFAR provided 16 awards of Centers of Excellence in Geriatric Medicine and Training what has been accomplished through the efforts of the more than 2,600 $75,000 for one to two years to researchers whose work AFAR has helped advance. The collective results of initiative, created to address the critical shortage of geriatric junior faculty (MDs and PhDs) to these gifted individuals’ discoveries will lead to healthier, more productive and faculty members in the nation’s medical schools. Operating conduct research that serves as more independent lives for untold numbers of people throughout the world. the basis for longer term research since 1988, and currently at 28 institutions across the The theme of this annual report is “The Faces of Discovery”. We want efforts. AFAR-supported investigators Diana Jacobs Kalman country, this program has produced hundreds of geriatric- to honor those who made, and continue to make, important scientific Chair, AFAR Board of Directors study a broad range of biomedical ally knowledgeable scientists, teachers and clinicians. We discoveries. Their research is the cornerstone of our future. Five of these topics. In 2009, research topics individuals, scientists who have received AFAR awards, and several of whom included the genetic control of are proud to partner with AFAR on this key effort as they are now key contributors to AFAR’s Review Committees, are highlighted longevity, mechanisms of cartilage take on the responsibility of the Program Office to manage in this report. cell degradation, to the effects of the Centers of Excellence. We know that the AFAR staff will aging on functional and structural There are many others affiliated with AFAR whom we gratefully acknow- organization of associative memory. manage this effort efficiently and with cost-effectiveness.” ledge as we write this report. First amongst them is AFAR’s founder, Irving

Wright, whose vision we still follow today. We must also pay tribute to Corinne H. Reider, EdD others who significantly contribute to AFAR, including the members of Medical Student Executive Director, The John A. Hartford Foundation AFAR’s Board, National Scientific Advisory Council, Research Committee Training in Aging Stephanie Lederman and the dedicated members of AFAR’s staff. All, in various important Research (MSTAR) Executive Director, AFAR ways, contribute to the cause of supporting and advancing healthier aging Program through biomedical research. Julie Martin Mid- The Rosalinde and The partnership program among AFAR continues to dedicate tremendous energy and financial resources to Career Awards Arthur Gilbert the National Institute on Aging, supporting researchers—it is our priority. However, we implement numerous in Aging Research Foundation/ AFAR New the American Federation for Aging other important initiatives as well in support of our mission, as detailed in Investigator Awards Research, MetLife Foundation, The program, sponsored by this report. in Alzheimer’s Disease the John A. Hartford Foundation The Ellison Medical Foundation, One of AFAR’s greatest strengths has always been our partnerships, and and several other funders, provides awarded two four-year awards In the third year of the program, we thank our numerous partners whose generosity has helped make us medical students with an enriching of $550,000 each in support of two The Gilbert Foundation and AFAR, a success. We sustain many long-term, solid relationships with foundations, experience in aging-related research outstanding mid-career scientists with additional support from an industry and our individual contributors. We are proud to state that this year and geriatrics, under the mentorship who are pursuing novel research anonymous donor, awarded five we launched three new significant partnerships with MetLife, sanofi-aventis of top experts in the field. Early in that has the potential for high payoff $75,000 grants to junior faculty and AARP. their training, students participate in in advancing our understanding of in the U.S. and Israel. These an eight- to twelve-week structured basic aging. In 2009, The Ellison investigators study the biological, research, clinical and didactic Medical Foundation renewed their genetic and environmental causes program in geriatrics. One hundred commitment to the program for of Alzheimer’s disease. By studying and thirty six medical students an additional five years. the early changes associated received scholarships in 2009. with Alzheimer’s from different The MetLife Foundation joined the but complementary angles, the partnership in 2009 and the John awards seek to accelerate devel- A. Hartford Foundation renewed its opment of diagnostic, preventative commitment to the program for an interventions and treatments. additional three years. 6 7

Grants Programs SPONSORS OF THE 2009 AFAR GRANT PROGRAMS

Paul Beeson Career Development Awards “As part of our commitment AFAR Research Grants Paul Beeson Career Development in Aging Research Awards in Aging Research to aging, we are pleased to Anonymous The Beeson Award is aimed at bolstering the current and severe shortage Anonymous partner with AFAR on the The AFAR Board of Directors of academic physicians who have the combination of medical, academic, National Institute on Aging and scientific training relative to caring for older people. Eight Scholars in Medical Student Training in Dorothy Dillon Eweson Endowment the U.S. were selected, each receiving a grant between $600,000 and Aging Research (MSTAR) National Institute of Mental Health The Glenn Foundation for Medical Research $800,000. The program is a public-private partnership among the National Program. AFAR is an ideal National Institute of Neurologic Disorders and Stroke Institute on Aging, the American Federation for Aging Research, The Atlantic The Partners of Goldman Sachs & Company Philanthropies, the John A. Hartford Foundation, the NIH Office of Dietary partner due to their long The Atlantic Philanthropies David W. Gore Supplements, The Starr Foundation and an anonymous donor. In 2009, the standing commitment in The John A. Hartford Foundation National Institute of Mental Health and the National Institute of Neurological supporting the science F. M. Kirby Foundation, Inc. Disorders and Stroke joined the partnership. The John A. Hartford Foundation The Starr Foundation of aging. I am certain that Neurosciences Education and Research Foundation renewed its commitment to the program in support of an additional three The NIH Office of Dietary Supplements cohorts of Scholars. MSTAR will continue its Diane Nixon stellar work in the coming Pfizer Inc Ellison Medical Foundation/AFAR Paul Beeson Career John A. Hartford decade and introduce more The Richard and Hinda Rosenthal Foundation Postdoctoral Fellows in Aging Development Awards Foundation’s Centers of the best-and-brightest in Aging Research of Excellence National Joseph L. K. Snyder Trust Research Program physicians-in-training to the Program for the Island Program Office The Starr Foundation The Ellison Medical Foundation of Ireland field of geriatric medicine.” The new Centers of Excellence The Irving S. Wright Endowment In 2007, the Beeson Program was (CoE) National Program Office, extended to Ireland to support established at AFAR, is assuming Dennis White, President and CEO, Medical Student Training in outstanding junior physician faculty a set of responsibilities resulting MetLife Foundation The Rosalinde and Arthur Gilbert Aging Research (MSTAR) Program committed to pursuing academic in a restructuring of the existing Foundation/ AFAR New Investigator National Institute on Aging careers in aging-related research, John A. Hartford Foundation’s Awards in Alzheimer’s Disease teaching and practice. Two Scholars CoE Program to a more central- Glenn/AFAR Break- The John A. Hartford Foundation throughs in Gerontology The Rosalinde and Arthur Gilbert Foundation were selected in 2009, receiving ized, streamlined operation, and MetLife Foundation awards of €339,390 and £228,000. with a more flexible annual (BIG) Award budgeting process. Lillian R. Gleitsman Foundation The goal of the Glenn/AFAR BIG Julie Martin Mid-Career Community Health Foundation program is to provide timely support Awards in Aging Research to a pilot research program that may of Western & Central New York Ellison Medical Foundation/AFAR Postdoctoral be of relatively high risk but which The Ellison Medical Foundation Henry Adelman Fund for Medical Student Education Fellows in Aging Research Program offers significant promise of yielding (Division of Geriatrics and Gerontology at Weill transforming discoveries in the This program addresses the current concerns about an adequate funding Cornell Medical College) base for postdoctoral fellows (both MDs and PhDs) who conduct research fundamental biology of aging. Two Glenn/AFAR Breakthroughs Carmen Pettapiece DO Student Research Fund in the fundamental mechanisms of aging. two-year grants of $200,000 each in Gerontology Awards were awarded in 2009. Fourteen postdoctoral fellows at all levels of training were funded in 2009. The Glenn Foundation for Medical Research Their awards range from $45,218 to $59,402.

Program guidelines and applications can be obtained from www.afar.org. Complete information about AFAR grant programs, recipients, and sponsors can be found at www.afar.org/grants.html 8 THE FACES OF DISCOVERY 9

The AFAR Grant Review Process AFAR is proud to highlight the ground-breaking research of five extraordinary awardees. Scientists each, with a critical, yet different focus on the aging process, they endeavor to ensure that we live healthier, longer lives, less susceptible to disease and disability.

Steven Austad, PhD

AFAR receives five to seven Steven Austad, PhD, professor “We are very proud to partner Professor, Barshop Institute for Longevity and Aging Studies times as many qualified research of Cellular and Structural Biology with AFAR in supporting and Department of Cellular and Structural Biology proposals as can be funded each at the University of Texas Health University of Texas Health Science Center, San Antonio year for its broad-based series of Science Center, will assume the role researchers whose efforts 2010 Chair, AFAR Research Committee grants programs. Using a rigorous of Research Committee Chair. (*) For will make significant trans- review process, we ultimately fund the past two years Dr. Austad served formational contributions a small percentage of these high- as the chair of the Ellison/AFAR Post- quality proposals. doctoral Fellowship Program and towards the improvement Comparative Gerontology will be succeeded by Holly Brown- The AFAR National Scientific Advisory of healthcare. AFAR has the Borg, PhD, associate professor Council, consisting of more than 350 ability to identify some of the of Pharmacology at the University Much of our knowledge of the aging lived species, we hope to get a hint Translating comparative research of the nation’s leading researchers in of North Dakota in 2010. best and the brightest and process comes from a menagerie about what an animal has to do to be across species to therapies is aging and age-related fields, carefully of creatures that would seem, at first really long-lived. It strikes me that we important for the course of aging considers each proposal’s scientific AFAR’s high-quality administrative then support those whose glance, incapable of shedding any need at least a few animals that are research and will be the most merit. These leading physicians skills and review processes are ingenuity and curiosity will light on the subject of humans. And already successful at aging. If they’re beneficial, suggests Dr. Austad. and scientists in aging research well-known. Because of this, many drive the science forward yet most of what scientists know doing some things already that are I will predict that the biggest volunteer their time and expertise to foundations, individuals and cor- about the genetics and bio-chemistry better than what humans are doing, breakthrough in the next five conduct the initial scientific review porations turn to AFAR to manage to discover new information of human aging comes from a then that might provide a new type years of aging research will be of the applications for the biology their research grant programs. which will ultimately provide relatively small number of laboratory of approach to finding therapies that the discovery that improvement of aging programs. Applications are These grant programs have their better healthcare for our animals. Enter Dr. Steven Austad, slow aging. and extension of health can be then presented to AFAR’s Research own committees, drawn from who uses nontraditional animal best achieved through the use of Committee, which was chaired for the the large pool of superb scientists aging population.” species to study the causes of aging. One current project for Dr. Austad combination drugs, each with past three years by Roger McCarter, committed to AFAR’s important His work focuses on what the natural is studying the development of a its small beneficial effect but PhD, professor of Biobehavioral work. AFAR’s excellent reputation David Y. Norton, world can teach us about improving rat-sized, short-lived monkey, the with these small effects working Health and a faculty member of the is due in large part to the efforts Company Group Chairman, health and extending life. marmoset, for health and longevity. multiplicatively. This is exactly Center for Developmental and Health of the senior researchers in Pharmaceuticals, This kind of research opens the door what happened in the treatment Genetics at Pennsylvania State our network. Johnson & Johnson By examining the mechanisms for potential drug trials in the near of HIV and cancer. Combination University. Beginning in 2010, of health and aging in a wide variety future, with important implications therapies instead of individual drugs of species outside typical lab rats, for human healthspan: Within five revolutionized these fields. Dr. Austad is able to compare how years I hope the marmoset will be biological processes operate to affect used in pre-clinical trials to test (*) To see a listing of the AFAR National Scientific Advisory Council (NSAC) members and the AFAR Research lifespan. By comparing what goes pharmaceuticals that promise to Committee, go to www.afar.org on in young adults in long- and short- improve and extend human health. 10 11

Brian K. Kennedy, PhD Nir Barzilai, MD

Associate Professor, Department of Biochemistry Director, Institute for Aging Research, and Professor of University of Washington Medicine and Molecular Genetics Albert Einstein College of Medicine 2003 AFAR Research Grant 1994 AFAR Research Grant 2008 Julie M. Martin Mid-Career Award in Aging Research 1997 Paul B. Beeson Career Development Award in Aging Research 2009 Vincent Cristofalo Rising Star in Aging Research Award

TOR Signaling and Lifespan Genetics of Longevity

Dr. Brian Kennedy has always had A pathway linking nutrient levels Dr. Kennedy highlights the great Dr. Nir Barzilai sees his career in Dr. Barzilai, along with Joe Verghese, Dr. Barzilai believes that future an interest in scientific research, to activation of the TOR kinase and impact that aging research can aging research as a journey. When MD, (2004 Beeson Scholar), worked aging research must focus on the beginning in high school, when protein translation has recently been have on human health and wellness I began my quest to understand on a study that builds translational rate of aging and extending human molecular biology was always new identified as a major conserved in the future. It has long been aging, there were few experts in bridges between genetic and lifespan to impact human health and exciting. As an undergraduate modifier of longevity. Dr. Kennedy’s said that aging is the biggest risk the field and certainly few mentors. clinical sciences targeted at frailty. and wellness. First, I predict that no student at Northwestern University, lab demonstrated that reduced factor for a range of diseases AFAR helped me transit from an The concept of “frailty” is used major advance will occur in specific he was introduced to yeast in the TOR signaling extends lifespan in that affect the elderly, but recent ‘orphan’ entering this field, to a to identify older adults with low disease without modulating the rate lab and has studied it ever since. yeast and recent evidence from findings have shown that delaying successful investigator. physiological reserves who are of aging, because it is the main risk Although I did research in other other investigators has shown that aging in mouse models really does at increased risk for disability and for those diseases. Furthermore, our areas, I came back to yeast studies rapamycin, a drug that inhibits provide protection from many of His AFAR-supported research mortality. While frailty is common effort to determine ways to extended during my years at MIT, which helped the TOR pathway, significantly these diseases. The translational has spanned many areas, including with advancing age, the age of human lifespan will be a Pyrrhic identify SIR2 as an aging gene. extends lifespan in mice. Research possibilities that may come out of Dr. a focus on the genetics of longevity. onset and speed of progression are victory if the extended lifespan is not Most importantly, I believe exciting on this pathway opens the door Kennedy’s lab and TOR research are Dr. Barzilai’s recent studies have quite variable. Frailty results from a one that includes good quality of discoveries are still out there, and for pharmacological intervention exciting—he is working on molecular- centered on how a group of combination of genetic and biological life, less age-related diseases and I plan to pursue them. in aging and age-related diseases. level genetic science that can lead to centenarians are protected from factors. Unlike biological changes that meaningful cognitive function. Dr. Approaches in Dr. Kennedy’s lab real therapies down the road. a variety of age-related diseases. may result in frailty at all ages, geno- Barzilai emphasizes that quality of Dr. Kennedy’s current work focuses are directed at identifying the His main hypothesis is that those types causative for frailty are less life is his paramount goal and that on identifying the genes and cellular correct pathways to target with subjects have protective changes likely to manifest only at extremes his fondest wish is to extend life- pathways that modulate aging. While drugs, and understanding how in their genes. These studies impli- of age. Dr. Barzilai hypothesized span while staving off disease. studies in yeast, worms and flies have these pathways control the aging cated several single-nucleotide that some centenarians may escape shown that altering the activity of a process. The more detailed infor- polymorphisms in longevity. Most frailty because they have protective gene can dramatically extend lifespan, mation we know about these notably, the CETP codon 405 is genotypes. His research can identify those organisms differ dramatically pathways, the better our chances associated with a lower rate of genes and polymorphic alleles that from mammals. His lab therefore will be to develop appropriate memory decline and lower risk protect from diseases. Therefore, explores comparative approaches therapeutic interventions in this of incident dementia, including Dr. Barzilai explains, Associating that will apply in mammals. relatively unexploited realm of dis- Alzheimer’s disease and frailty. these genotypes with phenotype ease medicine. and implicating them in longevity may lead to a fundamental under- standing of the molecular basis of several important diseases. 12 13

Matthew R. Kaeberlein, PhD Woodring E. Wright, MD, PhD

Assistant Professor, Department of Pathology Professor of Cell Biology University of Washington University of Texas Southwestern Medical Center 2006 AFAR Research Grant 2009 AFAR Irving S. Wright Award 2007 Glenn/AFAR Breakthroughs in Gerontology (BIG) Award

Mechanisms of Dietary Restriction Telomeres and Telomerase in Aging and Cancer

Lifespan extension from dietary Gaining an understanding of which Dr. Kaeberlein is a prolific author. Biology has been a keen interest Telomeres form the caps that Dr. Wright is an author of over restriction has been observed in genes are involved in lengthening From 2005-2009 he has published, for Dr. Woodring Wright for as long protect the ends of chromosomes 200 peer-reviewed scientific many different organisms, but the lifespan is a critical step in advancing many as first author, more than as he can remember, whether as a from being degraded or fused publications and is a recipient of details of this phenomenon remain our knowledge of the aging processes. 40 papers in prestigious scientific young child fascinated by animals on to each other. Every time a normal numerous awards, including the poorly understood. Dr. Matthew We will attempt to define the genes journals. He continues his exploration his travels through the Philippines and cell divides, its telomeres become AlliedSignal Award for Research Kaeberlein’s research is focused that are involved in lifespan extension into the implications of dietary Australia, or as a student in Kansas, shorter, creating a continuing on Aging, the Hayflick Award from on understanding the mechanisms from dietary restriction in C. elegans. restriction and the important role catching snakes to bring to his future mechanism that limits the ability the American Aging Association underlying how reduced food Dietary restriction increases lifespan that regulation of protein translation high school biology teacher, an of normal cells to divide. This and an Ellison Medical Foundation consumption slows aging and in organisms ranging from yeast plays in determining longevity in individual whom he counts as one process, called replicative aging, Senior Scholar Award. increases lifespan in the nematode to mice. It is critical to determine invertebrate organisms. of his scientific inspirations. This acts as a tumor suppressor C. elegans. The discoveries from whether the mechanism(s) of lifespan fascination with biology developed mechanism. Dr. Wright’s work these efforts will be used to guide extension in these different organ- Dr. Kaeberlein describes the into a long-standing interest in aging has demonstrated that restoring future studies in more complex isms is similar or different. If the excitement in the field of aging- research. The biology of aging is a telomerase to normal cells allowed organisms, including humans. mechanism(s) are conserved, then related research, as the results of fundamental area where we had so them to become immortal. Along there is a good chance these same basic biology are being translated little knowledge and where so much with his long-term collaborator, processes will apply to humans. into potential human therapies. knowledge was needed. It was an Dr. Jerry Shay, he has also shown Speaking broadly, he has hopes area calling for exploration. that most cancer cells express The implications of this research are for three promising areas of research telomerase, an enzyme that can add profound for age-related diseases to reach their potential in the near Dr. Wright’s current work involves DNA to the telomere to counteract and disorders. The pathways that future: TOR inhibitors, AMP kinase the structure of telomeres, the telomere shortening, supporting the link dietary restriction to increased life- activators and sirtuin activators. use of immortalized cells for idea that cells have to overcome span appear to be highly evolutionarily It is my hope that drugs targeting regenerative medicine and the the limits of replicative aging in conserved. By understanding the one or more of these enzymes comparative biology of telomeres order to become malignant. His details of these pathways, scientists will be shown to have beneficial and replicative aging. studies have also demonstrated that will be able to identify potential effects against multiple age-related inhibiting telomerase in tumor cells targets for therapies that potentially diseases in people in the next five results in reestablishing the counting can be beneficial for many different years. This would energize the field mechanism, so that the tumor cells age-associated diseases in humans. and (hopefully) provide the political become mortal and eventually die. incentive to begin funding studies of the basic biology of aging at a level commensurate with their potential for improving human health. 14ACCOMPLISHMENTS WITH IMPACT 15

Sharing Knowledge AFAR Grantee AFAR Scientific International Media Briefing: “TIME AFAR Affiliate Conference Conference: “The Longevity Center— ON OUR SIDE: IS LIVING TO Amplifies Impact As part of our core mission, AFAR Aging Heart: A “Age Boom Academy” 100 WITHIN OUR GRASP?” creates opportunities for scientists Forty-five AFAR grant recipients Florida Affiliate Roadmap to Cardiac and clinicians to share knowledge presented posters at the twenty- AFAR collaborated with the AFAR grantees David Sinclair, PhD, The AFAR Florida affiliate, launched Independence” and exchange ideas to drive inno- second annual AFAR Grantee International Longevity Center to professor of Pathology and director in 2008, marked this year with vation in aging research. We are also Conference, held in Santa Barbara, On October 6th, the day following host its “Age Boom Academy”, of the Paul F. Glenn Laboratories the creation of a board of directors committed to providing information California, September 13-15, 2009. the Awards Dinner, 75 prominent bringing together journalists for for the Biological Mechanisms of comprised of key leaders in the to the public on new medical For the first time this year, a well- scientists and industry leaders a week-long immersion program Aging at Harvard Medical School, research and lay communities. findings that can help people live received informal roundtable session attended the AFAR 2009 scientific focused on key longevity and aging and Dellara Terry, MD, formerly Other key 2009 achievements longer lives, less susceptible to was held and facilitated by senior conference at the Union Club topics. The seminar is designed to associate director of the New included the institution of the disease and disability. faculty. Additionally, a special in New York City. The conference deepen journalists’ understanding of England Centenarian Study and affiliate’s first named grant, the program for the recipients of the provided a forum for exploring the unprecedented increase in aver- associate professor at the Boston AvMed Health Plans AFAR Research We communicate news of Gilbert/AFAR New Investigators fundamental aspects of aging and age life expectancy and learn how University School of Medicine, as Grant. Additionally, as part of medical and scientific innovations Awards in Alzheimer’s Disease cardiovascular diseases. the aging of the world’s popu-lation is well as Christoph Westphal, CEO the ongoing effort to cultivate an to the public through our web was held prior to the start of the affecting health, politics, the economy of Sirtris, a GSK company (of which environment of exchange, AFAR site (www.afar.org) and our By discussing the basic science of Grantee Conference. and other aspects of their beats. David Sinclair is a co-founder), Florida has hosted a lecture series educational web site, Infoaging cardiovascular disease as well as were the featured speakers at for Florida residents, in Miami, Tampa (www.infoaging.com), which is emerging research and advanced this March 19 media briefing held and Fort Lauderdale featuring AFAR sponsored by Pfizer, Inc. AFAR Awards Dinner: therapies, speakers offered a AFAR-AARP Healthspan at the Yacht Club in NYC. They grantees as speakers on various “Investing in Futures” comprehensive examination of the Institute To share knowledge within the discussed the latest research on the topics related to aging and health. relationship between aging and scientific community, we sponsor The 2009 AFAR Awards Dinner A new partnership between AFAR genetic, environmental and lifestyle An annual award luncheon and heart disease as we look to the conferences and meetings, creating was held on October 5th at the and AARP, the Healthspan Institute factors that may extend healthy life. scientific symposium is planned for future. AFAR honored three young opportunities for scientists and Union Club in New York City. will be launched in 2010. The Insti- Numerous members of the media February 11, 2010, with the first researchers for their age-related clinicians to disseminate timely More than 160 leaders from tute will serve to increase public attended including reporters from AFAR Award of Distinction named research on the heart: Dao-Fu Dai, and accurate information and to the corporate, foundation and access to science based information The New York Times, Forbes, in memory of Mark Beers. MD, PhD, University of Washington, exchange ideas. Some of our 2009 scientific communities, as well and translate it to the general public Newsweek and CBS News. The Seattle; Jewell Jessup, PhD, activities are described in detail on as individual AFAR supporters, in an effort to facilitate positive health briefing was supported in part by Wake Forest University School of these pages. Additionally, we hold attended. Honorees included: improvement and the experience an anonymous donor and Sirtris. Medicine; and Guadalupe Villarreal, ad hoc seminars for the media Frederic B. Garonzik (posthumously), of healthier aging. Jr., Harvard Medical School. highlighting key breakthroughs that former AFAR board member; John These recipients of the AFAR-GE “We are pleased to have AFAR as the media can report to the public. C. Whitehead, former Goldman Healthcare Junior Investigator our partner in the new Healthspan Sachs & Co. co-chairman and Award presented their work in a Institute being launched this year. former deputy secretary of state; poster session at the meeting. Together, we will educate the lay John C. Erickson, Erickson public about healthy aging and Retirement Communities; Husseini Information about the conference, serve as an interdisciplinary ‘action K. Manji, Johnson and Johnson including the proceedings write- tank’. The Healthspan Institute will Pharmaceutical Research and up and conference video footage, bring together researchers, gather Development; and Robert N. Butler, can be found at www.afar.org/ the latest knowledge from leading International Longevity Center. agingheartconf.html. Various scientists in this country and around Woodring E. Wright of University speaker Powerpoint presentations the world and make cutting edge of Texas Southwestern Medical are available by request. knowledge more broadly accessible Center received the Irving S. Wright to older consumers, professionals in Award and Brian K. Kennedy of the the aging arena, and policymakers.” University of Washington received 2009 AFAR Awards Dinner: (l-r) Anne Garonzik; AFAR Scientific Director, George Martin, MD; the Vincent J. Cristofalo Rising Star John Rother, Executive Vice President, Board Chair, Diana Jacobs Kalman; Honoree Robert N. Butler, MD; AFAR Executive Director, Stephanie Lederman; AFAR President, Terrie Fox Wetle, PhD; Honorees Husseini Manji, MD, in Aging Research Award. Policy & Strategy, AARP Brian K. Kennedy, PhD, Woodring E. Wright, MD, PhD. (seated l-r) Honorary Board Chair, George E. Doty and Honoree John C. Whitehead. 16JOIN US AMERICAN FEDERATION FOR AGING RESEARCH 17 2009 SUPPORTERS LIST

AN INVESTMENT IN AFAR. AN INVESTMENT IN INNOVATION. AFAR BOARD OF DIRECTORS George E. Doty Kaufmann Foundation Charles Beever Estate of Dorothy Dillon Eweson F. M. Kirby Foundation Marie A. Bernard Charles J. Fahey The Jan M. and Eugenia Richard W. Besdine James D. Gibbons Krol Charitable Foundation Rating charities: 88% Harvey J. Cohen Mark Monane Kronos Longevity Research Institute AFAR scores highest Research Grants Mark R. Collins James R. Rowen The Lucius N. Littauer Foundation Scholarship Ann M. Connolly Jesse Roth The Litwin Foundation, Inc. AFAR’s impact and low administrative Gaetano Crepaldi Donald Allen Snider MetLife Foundation expenses have secured a four-star 5% Helen K. Edelberg Hume R. Steyer The Ambrose Monell Foundation ranking—the highest possible— from Meetings + Charity Navigator, an independent Jay M. Edelberg William C. Stutt National Institute on Aging/ Publications National Institute of Health evaluator of the nation’s charities. Joseph M. Feczko Geoffrey A. Thompson AFAR has a track record of excellence Neurosciences Education and Research 4% Howard J. Federoff Patrick J. Waide, Jr. Foundation in Memory of Leon Thal demonstrating that donor dollars Management + Alexandra L. Gatje T. Franklin Williams go toward its mission of supporting Pfizer Inc General research on aging. Diana Jacobs Kalman Princeton Wealth Advisors of Mark S. Lachs CORPORATIONS/ FOUNDATIONS/ Raymond James and Associates 3% Kevin J. Lee EDUCATIONAL INSTITUTIONS The Rosenthal Family Foundation Fundraising William J. Lipton Anonymous sanofi-aventis Alexandra Foundation “Creating opportunities Stefania Maggi The Charles & Mildred The Atlantic Philanthropies Schnurmacher Foundation for scientists to exercise George M. Martin Roger J. McCarter Rose M. Badgeley Residuary The Sharonsteel Foundation their imaginations and Charitable Trust Allen W. Mead Sirtris Pharmaceuticals Bristol-Myers Squibb Company explore new directions Joan Murtagh Frankel Joseph L.K. Snyder Trust is critical to the advance- The James A. and Dorothy R. The Starr Foundation Diane A. Nixon Brunn Foundation ment of discovery. Our Clarence Pearson Strategic Communications The Carwill Foundation and Planning partnership with AFAR Joan L. Quinn Charina Foundation University of Washington— is an important part John B. Rhodes craigslist Charitable Fund Department of Biochemistry of our overall strategy AFAR Corinne H. Rieder The Ellison Medical Foundation The Isak & Rose Weinman to help sustain as many Richard L. Sprott GE Healthcare Foundation, Inc. Terrie T. Wetle developing investigators Genomic Health Inc. Joyce M. Yaeger in the field of aging The Gerontological PARTNERS OF GOLDMAN Gary L. Zwerling Society of America SACHS & COMPANY as possible.” The Rosalinde and Arthur Anonymous AFAR FORMER, HONORARY Gilbert Foundation George T. Boyer Richard L. Sprott, PhD, AND EMERITUS DIRECTORS Glenn Foundation for Medical Research Leon Cooperman Executive Director, John P. Blass The Ellison Medical Foundation The Glickenhaus Foundation John P. Curtin John M. Bonk The John A. Hartford Foundation George E. Doty Jacob A. Brody The Lowell F. Johnson Foundation Robert N. Downey Robert Butler Johnson and Johnson Pharmaceutical Robert A. Friedman Judith Campisi Research & Development, L.L.C. Richard L. Menschel Rose W. Dobrof The Marion Esser 18 19 BOARD BOARD OF DIRECTORS STAFF Irving S. Wright, MD Mark H. Beers, MD+ Stephanie Lederman Founder Immediate Past President Executive Director William J. Lipton, JD, LLM, CPA Charles Beever, MBA** Katherine Kelly Apple Chair, Board of Directors Communications and Development Marie A. Bernard, MD Gaetano J. Muzio Tina Fisher Robert Tober Program Associate Federal Liaison—ex-officio Suzanne M. Nora Johnson Reeva Friedman Debbie Turkowski Catherine Cullar BOARD OF DIRECTORS Harvey J. Cohen, MD Willard J. Overlock, Jr. Robert E. and Sandi F. Friedman Vincent Virga EXECUTIVE COMMITTEE Administrative Manager Michael Rantz Anne G. Garonzik Taylor Warnken Mark R. Collins Terrie T. Wetle, PhD Michelle Elliott Eric P. Sheinberg Mr. and Mrs. Neal S. Garonzik Sue Ann Weinberg President Gaetano Crepaldi, MD Accounting Assistant David Silfen Karen A. Goraleski Michael Weiner Roger J. McCarter, PhD Helen K. Edelberg, MD, MPH Stacey Harris, Communications* William C. Stutt David W. Gore Cheryl Yarboro President-Elect Ronald Tauber Paul L. Hertenstein Terence Zehrer Jay M. Edelberg, MD, PhD Hattie Herman Program Officer George M. Van Cleave Franklin W. Hobbs Diane A. Nixon Howard J. Federoff, MD, PhD Vice Chair Nancy O’Leary John L. Weinberg Jan Housinger AFAR ALUMNI FUND Joseph M. Feczko, MD* Sidney J. Weinberg, Jr. Keith Hull Anonymous George M. Martin, MD Director, Development Alexandra L. Gatje J. Fred Weintz Robert Kahn Itamar B. Abrass Scientific Director Jacalyn Schwartz John C. Whitehead Leib Katz Nir and Laura Barzilai Richard W. Besdine, MD Mikhail Y. Gurfinkel, JD Director, Finance Victor R. Wright Marilyn Katz Robert D. Blank AFAR Medical Officer Mark S. Lachs, MD, MPH Veronica Smith Program Associate Gary L. Zwerling Wayne Kuklinski Donna Z. Bliss Steven N. Austad, PhD Kevin J. Lee, PhD Roy J. Zuckerberg Larissa Lapteva Patsy Brannon and Wes Buchanan, Jr. Vice President Odette van der Willik Stefania Maggi, MD, PhD, MPH Judith and Edwin Leonard Douglas E. Brash Ann M. Connolly, MBA Director, Grant Programs INDIVIDUALS Henry A. and Eleanor G. Lowet Dennis E. Buetow Treasurer Rick A. Martinez, MD** Anonymous John B. McKitterick Mary Lou Caspers Clarence Pearson, MPH Joan L. Quinn, RN, MSN, FAAN *Term ends 12/31/09 Roger W. Ackerman James M. McLaughlin Barbara Clark Secretary Corinne H. Rieder, EdD Audrey S. Amdursky Helen Mitchell James R. Connor **Term begins 01/01/10 Joan Murtagh Frankel, JD Donald A. Snider, PhD* Vincent Barbetta Marilyn Morrissey Linda A. Dokas + Deceased Allen W. Mead, MD* Louis Barkovitz Richardson K. Noback Elizabeth Kensinger John T. Watters, MB, ChB** John Beilenson R.E. Nystrom Gary Kochersberger John B. Rhodes, MBA Alastair J.J. Wood, MB, ChB** Ronald and Carol Beyna Sarah Okada Kathy Magnusson Richard L. Sprott, PhD Gary L. Zwerling, MBA Leonard and Barbara Bornstein William J. Pierson Marcia Gordon and David Morgan Joyce M. Yaeger Nancy Burstein Catherine McDonnell Pietronuto Vincent and Adele Monnier Stephanie Lederman, EdM Roz Byrne Mitchell Pines Mervyn J. Monteiro Executive Director Robert L. Cahill, Jr. Gail Post Marcus and June Reidenberg DEDICATION Mario Calderon Frank and Diana Pucino Alec Rooke HONORARY AND Mary Ann Cotter Lorraine Reich Martin J. Sadowski EMERITI DIRECTORS This annual report is dedicated to Diana Jacobs Kalman, who has provided Margaret F. Cristofalo Joseph Reiter Neil Segal AFAR with fifteen years of exemplary service, support and leadership as chair, Gregory Daigle Sheila Shapira Wei Sun George E. Doty officer and member of the board of directors. Under her direction, AFAR has Honorary Chair Patricia Denney Lynn and Timothy Shea Janet Sunness grown into the vibrant, future-focused organization it is today, dedicated to Dianne Dexter Jeffrey Siegel Trygve Tollefsbol Hadley C. Ford, ScB, MBA nurturing the growth and advancement of early career scientists in the field Chair, Emeritus of aging research. Diana has been a true inspiration to both the staff and the Idalice Dickinson Frank Skerbetz Mitchell Tucker board of directors, driving the growth and development of AFAR forward into Linda Dokas Ivan and Rosalind Stern Jeremy D. Walston Diana Jacobs Kalman the twenty-first century. Her passion for advancing the landscape of geriatric Gerald P. and Lydia M. Esmer Nathan Strug Hoau-Yan Wang Chair, Emeritus medicine and aging research has enabled AFAR to position itself as a nation- Senator John H. Glenn ally recognized leader in the field. We salute her commitment, dedication and Honorary Director service to AFAR. 20

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