Molecular and Cellular Biology

MOLECULAR AND CELLULAR BIOLOGY

VOLUME 6 0 JUNE 1986 0 NUMBER 6

Aaron J. Shatkin, Editor in Chief(1990) David J. L. Luck, Editor (1987) Paul S. Sypherd, Editor (1990) Roche Institute ofMolecular Biology Rockefeller University University of California Nutley, N.J. New York, N.Y. Irvine Harvey F. Lodish, Editor (1986) Louis Siminovitch, Editor (1990) Harold E. Varmus, Editor (1989) Whitehead Institute for Biomedical Mount Sinai Hospital University of California Research Toronto, Canada San Francisco Cambridge, Mass. Joan A. Steitz, Editor (1990) Yale University New Haven, Conn.

EDITORIAL BOARD Frederick W. Alt (1987) Jack F. Greenblatt (1988) Steven McKnight (1986) Milton J. Schlesinger (1986) Arnold J. Berk (1988) Leonard P. Guarente (1988) Janet E. Mertz (1987) Fred Sherman (1988) Alan Bernstein (1987) James E. Haber (1987) Robert L. Metzenberg (1988) Anna Marie Skalka (1986) Barbara K. Birshtein (1987) Hidesaburo Hanafusa (1986) Robert K. Mortimer (1988) Arthur Skoultchi (1988) J. Michael Bishop (1987) Ari Helenius (1987) Paul Neiman (1986) Frank Solomon (1988) Michael R. Botchan (1987) Ira Herskowitz (1987) Joseph R. Nevins (1987) Pamela Stanley (1988) David Botstein (1987) James B. Hicks (1986) Carol Newlon (1988) Bruce Stillman (1988) Bruce P. Brandhorst (1987) Alan Hinnebusch (1988) Harvey L. Ozer (1988) Bill Sugden (1988) James R. Broach (1988) Michael J. Holland (1987) Mary Lou Pardue (1988) Jack Szostak (1987) Joan Brugge (1988) Greg Hollis (1987) Carl S. Parker (1987) Lawrence H. Thompson (1988) Mario R. Capecchi (1987) Anita K. Hopper (1988) Ira H. Pastan (1988) Shirley M. Tilghman (1987) John A. Carbon (1987) Peter M. Howley (1988) David Patterson (1988) Robert Tjian (1987) Lawrence A. Chasin (1988) Tony Hunter (1986) Gianni Piperno (1988) Jonathan R. Warner (1987) Nam-Hai Chua (1988) Larry Kedes (1988) John R. Pringle (1988) Alan M. Weiner (1987) Don W. Cleveland (1987) Robert S. Kerbel (1988) Jean-Paul Revel (1988) Harold Weintraub (1988) Christopher Coleclough 1987) Barbara Knowles (1986) Daniel B. Rifkin (1988) Reed B. Wickner (1988) Terrance G. Cooper (1987) Marilyn Kozak (1988) G. S. Roeder (1988) Fred Winston (1988) Elizabeth A. Craig (1988) Monty Krieger (1986) Robert G. Roeder (1988) Owen Witte (1988) James E. Dahlberg (1987) Arnold J. Levine (1987) Naomi E. Rosenberg (1988) Elton T. Young (1987) James E. Darnell, Jr. (1988) Susan Lindquist (1987) Norman P. Salzman (1988) Michael Young (1988) G. N. Godson (1987) Paul T. Magee (1988) Paul Schedl (1987) Edward Ziff (1988) Michael Green (1988) James Manley (1986) Randy W. Schekman (1988)

Helen R. Whiteley, Chairman, Publications Board Kirk Jensen, Director ofPublications Linda M. Illig, Managing Editor, Journals Linda M. Illig, Production Editor Molecular and Cellular Biology (ISSN 0270-7306) is devoted to the advancement and dissemination offundamental knowledge concerning the molecular biology of eucaryotic cells, of both microbial and higher organisms. Instructions to authors are published in the January issue each year; reprints are available from the editors and the Publications Department. The journal is published monthly, one volume per year. The nonmember subscription price is $150 per year; single copies are $21. The member subscription price is $41 (foreign $54 [surface rate]) per year; single copies are $7. Correspondence relating to subscriptions, reprints, defective copies, availability of back issues, lost or late proofs, disposition of submitted manuscripts, and general editorial matters should be directed to the ASM Publications Department, 1913 I St., NW, Washington, DC 20006 (area 202 833-9680). Claims for missing issues from residents of the United States, Canada, and Mexico must be submitted within 3 months after publication of the issues; residents of all other countries must submit claims within 6 months of publication of the issues. Claims for issues missing because offailure to report an address change or for issues "missing from files" will not be allowed. Second-class postage paid at Washington, DC 20006, and at additional mailing offices. POSTMASTER: Send address changes to Molecular and Cellular Biology, ASM, 1913 I St., NW, Washington, DC 20006. Made in the United States of America. Copyright C) 1986, American Society for Microbiology. .± 11! All Rights Reserved. The code at the top of the first page of an article in this journal indicates the copyright owner's consent that copies of the article may be made for personal use or for personal use of specific clients. This consent is given on the condition, however, that the copier pay the stated per-copy fee through the Copyright Clearance Center Inc., 21 Congress St., Salem, MA 01970, for copying beyond that permitted by Sections 107 and 108 of the U.S. Copyright Law. This consent does not extend to other kinds of copying, such as copying for general distribution, for advertising or promotional purposes, for creating new collective works, or for resale. Author Index

Adachi, Yasuhisa, 2168 Futcher, Bruce, 2213 Lewis, John A., 1998, 2262 Sen, Ganes C., 2062 Fyrberg, Eric A., 1965 Liboi, Elio, 2275 Shen, Che-Kun James, 2041 Beaudet, Arthur L., 2257 Loeken, Mary R., 2020 Shenk, Thomas, 2207 Bernstein, Julie A., 2115 Garcia, Irene, 1974 Shilo, Ben-Zion, 2241 Blau, Helen, 2137 Gehring, Walter J., 2011 MacKay, Vivian L., 2106 Shuster, Jeffrey, 1894 Bond, Beverley J., 2080 Gillespie, Frances P., 1951 Maryon, Edward B., 2053 Smith, Michael, 1894 Borde, Janine, 1875 Gordon, Jon W., 2158 Matkovich, Diana A., 2262 Sordat, Bernard, 1974 Bostian, K. A., 1855 Gottlin-Ninfa, Elizabeth, 2185 Matthes, Hans, 2098 Swimmer, Candace, 2207 Bostian, S. J., 1855 Gregor, Polly D., 1903 May, Evelyne, 1875 Boyd, Patricia A., 2223 Grundstrom, Thomas, 2098 Minty, Adrian, 2125, 2137 Tait-Kamradt, A. G., 1855 Brady, John, 2020 Grzesiuk, Elzbieta, 2053 Mitchell, Arthur, 2223 Takahashi, Keikichi, 2098 Bryan, Philip N., 2249 Guarente, Leonard, 1936 Mitchell, Pamela J., 1926 Takeuchi, Tomio, 2198 Burch, John B. E., 1886 Moon, Anne M., 1991 Testa, Ugo, 2275 Hallberg, Richard L., 2267 Morgenstern, Jay P., 1917 Thill, G. P., 1855 Campbell, Bruce A., 2068 Hartig, Andreas, 2106 Morrison, Sherie L., 1903 Toda, Takashi, 2168 Carbon, John, 2213 Haseltine, William A., 1983 Morten, John E. N., 2223 Turner, K. J., 1855 Carbone, Arlene, 1866 Hastie, Nicholas D., 2223 Mosca, J. D., 2279 Carroll, Dana, 2053 Haug, Martina, 2233 Uehara, Yoshimasa, 2198 Challberg, Mark D., 2115 Heguy, Adriana, 2149 Nishimoto, Takeharu, 2027 Umezawa, Hamao, 2198 Chambon, Pierre, 2098 Helland, Dag E., 1983 Niwa, Osami, 2168 Urlaub, Gail, 1926 Chan, R. V. L., 1894 Holly, Julie, 2106 Chasin, Lawrence, 1926 Hong, Tsai-Hsia, 1951 O'Brien, William E., 2257 Van Der Ploeg, Lex H. T., Chen, Anne C., 1917 Hori, Makoto, 2198 Ohtsubo, Motoaki, 2027 1991 Cocke, Thomas, 2207 Hsiao, W.-L. W., 1943 Omilli, Francis, 1875 van Heyningen, Veronica, Corces, Victor G., 2271 Hwu, Patrick, 2253 2223 Cox, David, 1894 Parada, Luis F., 1917 Varesio, Luigi, 2253 Cranston, Gwen, 2223 Jackson, Marian J., 2257 Parkhurst, Susan M., 2271 Villarreal, Luis P., 2068 Pelosi, Elvira, 2275 Davidson, Norman, 2080 Kaback, David B., 2185 Perez-Stable, Carlos, 2041 Walter, Gernot, 1866 Deppert, Wolfgang, 2233 Kai, Ryosuke, 2027 Peschle, Cesare, 2275 Warner, Jonathan R., 2089 Diggelmann, Heidi, 1974 Kaplan, David R., 2033 Pitha, P. M., 2279 Weinberg, Robert A., 1917 Doetsch, Paul W., 1983 Karin, Michael, 2149 Piwnica-Worms, Helen, 2033 Weinstein, I. B., 1943 Donelson, John E., 1991 Karlik, Christine C., 1965 Porteous, David J., 2223 Welsh, J. Douglas, 2207 Dunand, Monique, 1974 2115 West, Adrian, 2149 Kedes, Larry, 2125, 2137 Porter, Jane M., Whitman, Malcolm, 2033 Khoury, George, 2020 Wildeman, Alan G., 2098 Eisenstadt, Jerome M., 1951 Kim, Kwang-Soo, 1936 Rauccio-Farinon, Eugenia, Williams, Trevor J., 2179 Elion, Elaine A., 2089 Kleinberger, Tamar, 1958 1974 Wintzerith, Marguerite, 2098 Elliott, Q. D., 1855 Klemenz, Roman, 2011 Richards, Robert I., 2149 Wolff, Roger K., 2053 Ernoult-Lange, Michele, 1875 Koch, Werner, 1866 Roberts, Thomas M., 2033 Wright, Scott H., 2053 Esser, Klaus M., 1991 Kraehenbuhl, Jean-Pierre, Rogers, D. T., 1855 Wu, T., 1943 Etkin, Sara, 1958 1974 Rosenkrantz, Mark S., 1936 Evans, Marilyn I., 1886 Kramer, R. A., 1855 Rossi, Giovanni Battista, 2275 Yanagida, Mitsuhiro, 2168 Kusari, Jyotirmoy, 2062 Young, Elton, 1894 Fantes, Judy A., 2223 Saari, Gena, 2106 Young, Howard A., 2253 Fletcher, Judy M., 2223 Land, Hartmut, 1917 Schatz, Christian, 2098 Yu, Josephine, 1894 Folk, William R., 2249 Lavi, Sara, 1958 Segal, Daniel, 2241 Fried, Mike, 2179 Lenardo, Michael J., 1991 Sekiguchi, Mutsuo, 2027 Zenke, Martin, 2098 If you are working in the area of eucaryotic cell biology, then you need EDITOR IN CHIEF: Aaron J. Shatkin EDITORS: Harvey F. Lodish, David J. L. Luck. Louis Siminovitch, Joan A. Steitz. Paul S. Sypherd. Harold E. Varmus

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