Annual Report 2008 Table of Contents
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Genetic and Epigenetic Mechanisms of the Regulation of Mouse Embryonic Stem Cells Self-Renewal by the Pluripotency Transcription Factor Nanog
Genetic and epigenetic mechanisms of the regulation of mouse embryonic stem cells self-renewal by the pluripotency transcription factor Nanog Victor HEURTIER Thèse de doctorat de Biologie Dirigée par Pablo NAVARRO GIL Laboratoire Epigénétique des cellules souches – Institut Pasteur Sorbonne Université Ecole doctorale Complexité du Vivant (ED 515) Présentée et soutenue publiquement le 18/09/2018 Devant un jury composé de : Président : Pr MOUCHEL-VIELH Emmanuèle, Professeur Rapporteur : Dr SAVATIER Pierre, Directeur de Recherche Rapporteur : Dr RADA-IGLESIAS Alvaro, Chef d’équipe Examinateur : Dr AZUARA Veronique, Maître de conférences Examinateur : Dr PINSKAYA Marina, Maître de conférences Directeur de thèse : Dr NAVARRO GIL Pablo, Chef d’équipe Abstract Mouse embryonic stem (ES) cells are derived from the pre-implantation blastocyst and are able to maintain their pluripotent state through virtually limitless cell divisions in vitro. The study of the mechanisms regulating the specific features of ES cells led to the discovery of the transcription factors (TFs) governing their unique transcriptome. Among those TFs, Nanog plays a central role in the gene regulatory network that supports ES cells self-renewal. However, the molecular mechanisms by which Nanog exerts its functions are not fully elucidated. We adapted an inducible CRISPR activation (CRISPRa) system in mouse ES cells and demonstrated its functionality to stimulate transcription at endogenous loci. We then accurately determined the list of Nanog responsive genes using gain (CRISPRa cell line) and loss of function experiments and total RNA sequencing. Moreover, the DNA binding profiles of distinct pluripotency TFs were assessed genome-wide by chromatin immunoprecipitation (ChIP) and sequencing upon Nanog depletion and revealed the importance of the latter in the regulation of the pluripotency network activity at thousands of loci. -
Which Canadian Charities Had the Largest Assets in 2014?
www.canadiancharitylaw.ca Which Canadian charities had the largest assets in 2014? By Mark Blumberg (March 23, 2016) We recently reviewed the T3010 information for 2014. It covers about 84,370 of the 86,000 registered charities that have so far filed their return and that have been entered into the CRA’s database. Canadian registered charities are currently required to disclose on the T3010 their assets. The total assets of all the 84,370 registered charities were about $373,050,327,255.00. Below we have a table of Canadian charities and how much they spent as reported for the 2014 fiscal year. Thank you to Celeste Bonas, an intern at Blumbergs, for helping with this project. The Sean Blumberg Transparency Project is in memory of my youngest brother Sean Blumberg. Sean was a sweet, kind person, a great brother who helped me on a number of occasions with many tasks including the time consuming and arduous task of reviewing T3010 databases and making them into something useful. As part of the Sean Blumberg Transparency Project, Blumbergs has been releasing information on the Canadian charity sector to provide a better understanding of the size, scope, complexity and challenges of the sector. Please review my caveats at the end about the reliability and usage of T3010 information. 1 www.canadiancharitylaw.ca List of Canadian charities with the largest assets in 2014 Line 4200 Name of Canadian Registered Charity largest assets 1. ALBERTA HEALTH SERVICES $9,984,222,000.00 2. THE MASTERCARD FOUNDATION $9,579,790,532.00 3. THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO $7,681,040,000.00 4. -
2015 Annual Report
1 TABLE OF CONTENTS TABLE OF CONTENTS ............................................................................................................................. 2 HISTORY OF THE GAIRDNER FOUNDATION .................................................................................... 3 MISSION ...................................................................................................................................................... 3 NATIONAL AND STUDENT OUTREACH PROGRAMS ....................................................................... 4 MESSAGE FROM THE CHAIR ............................................................................................................... 5 MESSAGE FROM THE PRESIDENT/SCIENTIFIC DIRECTOR ......................................................... 6 2015 YEAR IN REVIEW ............................................................................................................................. 7 REPORT ON 2015 OBJECTIVES ............................................................................................................ 14 THE YEAR AHEAD: OBJECTIVES FOR 2016 ..................................................................................... 16 THE GAIRDNER FOUNDATION VALUES OUR 2015 SPONSORS ................................................... 18 GOVERNANCE ......................................................................................................................................... 20 MEDICAL REVIEW PANEL 2015 ......................................................................................................... -
2015 Annual Summary Corporate Plan
The Gairdner Foundation Corporate Plan 2015 1 TABLE OF CONTENTS PAGE Section I About the Gairdner Foundation 2 Objectives and Achievements to Date 5 Benefits 7 Section II Performance Results for 2014 Activities 7-8 Detailed 2014 Evaluations 9-10 Planned Activities and Anticipated Results 2015 11 Section III Financial Summary 12 Planned Receipts and Disbursements 2015 13-15 Section IV Risk Management 16 Section V Performance Monitoring 17-19 2 THE GAIRDNER FOUNDATION CORPORATE PLAN EXECUTIVE SUMMARY HISTORY The Gairdner Foundation was created by James A. Gairdner to recognize and reward the achievements of medical researchers whose work “contributes significantly to improving the quality of human life”. The Foundation is a Canadian organization that has never lost sight of its primary mission – the recognition of scientists it deemed to have made the most important breakthrough discoveries in biomedical science. It’s recipients are responsible for the discovery of the structure of DNA, the eradication of smallpox, CT scans, MRI machines, the human genome, the cure for ulcers, and the vaccine against HPV, to name a few. Since the first awards were granted in 1959, the Canada Gairdner Awards have become Canada's foremost international award- and one of the most prestigious awards in medical science. Our track record of consistent high quality adjudication and selection by the independent adjudication committees have resulted in global recognition and esteem. The Gairdner was incorporated in December 1957 as a charitable corporation under the laws of the Province of Ontario, Canada. During 2013, the Foundation was continued as a federal corporation under the Canada Not-For-Profit Corporations Act. -
The Complex Life of the Complex Life Of
The Complex Life of mRNA EMBO|EMBL Symposium 5–8 October 2016 Heidelberg | Germany EMBL Advanced Training Centre KEYNOTE SPEAKERS Thomas Cech Patrick Cramer Jennifer Doudna University of Colorado Boulder, USA MPI for Biophysical Chemistry, Germany University of California, Berkley, USA ABSTRACT SUBMISSION DEADLINE CONFIRMED SPEAKERS 13 JULY 2016 Maria Barna Rachel Green Shona Murphy Stanford University, USA Johns Hopkins University Sir William Dunn School of Pathology, UK School of Medicine, USA REGISTRATION DEADLINE Simon Bullock Karla Neugebauer 24 AUGUST 2016 MRC Laboratory of Molecular Biology, UK Chuan He Yale University, USA The University of Chicago, USA Emmanuelle Charpentier Uwe Ohler MPI for Infection Biology, Germany Alan Hinnebusch Max Delbrueck Center, Berlin, Germany ORGANISERS NIH, USA Anne Ephrussi Jeffrey Chao Laura Ranum EMBL Heidelberg, Germany Friedrich Miescher Institute for Elisa Izaurralde University of Florida, USA Biomedical Research, Switzerland MPI for Developmental Biology, Germany Nahum Sonenberg Erin Schuman McGill University, Canada Elena Conti Jeff Kieft MPI for Brain Research, Germany MPI of Biochemistry, Germany University of Colorado, USA Joan Steitz Yukihide Tomari Yale University, USA Victoria D'Souza Iain MacRae The University of Tokyo, Japan Harvard University, USA The Scripps Research Institute, USA David Tollervey Jonathan Weissman Wellcome Trust Centre for Cell Biology, UK Caroline Dean James Manley University of California, John Innes Centre, UK Columbia University, USA San Francisco, USA Additional speakers will be Gideon Dreyfuss Christine Mayr Marat Yusupov selected from abstracts. Perelman School of Medicine at the Memorial Sloan Kettering Cancer Institute of Genetics and Molecular University of Pennsylvania, USA Center, USA and Cellular Biology (IGBMC), France CONTACT www.embo-embl-symposia.org [email protected]. -
Bulletin the Canadian Society for Molecular Biosciences La Société Canadienne Pour Les Biosciences Moléculaires
Bulletin The Canadian Society for Molecular Biosciences La Société Canadienne pour les Biosciences Moléculaires 2013 www.csmb-scbm.ca Bulletin The Canadian Society for Molecular Biosciences La Société Canadienne pour les Biosciences Moléculaires 2013 www.csmb-scbm.ca Cover images were provided by Dr. Benoit Chabot (see article standing on p32). 2 CSMB | SCBM Bulletin 2013 CSMB Board for 2013 ...............................................................................................................................................................5 President’s Report 2013 .........................................................................................................................................................7 Incoming Member of the Executive Board Martin Bisaillon, Councillor ...............................................................................................................................................9 Minutes of the 56th Annual General Meeting 2013 ...................................................................................................10 Financial Statement 2013 ....................................................................................................................................................12 56th Annual Meeting, Niagara-on-the Lake Meeting Schedule ..............................................................................................................................................................17 Scenes from the Meeting .................................................................................................................................................25 -
Dr. Adolfo J. De BOLD
Dr. Adolfo J. de BOLD September 2015 Page 1 of 40 HOME ADDRESS: OFFICE ADDRESS: 5503 South Island Park Drive Department of Pathology and Laboratory Manotick, Ontario K4M 1J2 Medicine Phone: (613) 692-6194 University of Ottawa, Faculty of Medicine 4155-451 Smyth Road Ottawa, Ontario K1H 8M5 Phone: (613) 562-5422 [email protected] EDUCATION 1961 - 1967 National University of Córdoba, Argentina 1968 Professional Degree: Clinical Biochemist 1968 - 1973 School of Graduate Studies, Queens University, Kingston, Ontario, Canada 1971 M.Sc. (Experimental Pathology) "Studies on the Relationship between the Catecholamine Distribution in the Atrium and the Specific Granules Present in Atrial Muscle Cells" 1973 Ph.D. (Experimental Pathology) "The Relationship Between Morphology and Function in the Atrial Cardiocyte. A study With Emphasis on the Secretory Characteristics of the Mammalian Atrium" PROFESSIONAL APPOINTMENTS 1974 Laboratory Scientist, Pathology Laboratory, Hotel Dieu Hospital, Kingston, Ontario, Canada. 1974 Assistant Professor of Pathology, Department of Pathology, Faculty of Medicine, Queen's University, Kingston, Ontario, Canada (Tenured, 1981). 1982 Associate Professor of Pathology, Faculty of Medicine, Queen's University, Kingston, Ontario, Canada. 1985 Professor of Pathology, Faculty of Medicine, Queen's University, Kingston, Ontario, Canada. 1986-1993 Director of Research, University of Ottawa Heart Institute Research Centre, Ottawa Civic Hospital. 1989-1995 Distinguished Research Professor, Heart and Stroke Foundation of Ontario. 1986-1995 Adjunct Professor of Pathology, Queen's University, Kingston, Ontario, Canada. 1986-2013 Professor of Pathology and Laboratory Medicine Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada 1986-2013 Cross-appointment, Department of Cellular and Molecular Medicine, Faculty of Dr. Adolfo J. -
NCI Budget Fact Book for Fiscal Year 1996
NCI FACT BOOK National Cancer Institute 1996 U.S. DEPARTMENT NATIONAL INSTITUTES OF HEALTH AND OF HEALTH HUMAN SERVICES The information set forth in this publication is compiled and amended annually by the financial management staff of the National Cancer Institute and is intended primarily for use by members of the Institute, principal advisory groups to the Institute and others involved in the administration and management of the National Cancer Program. Questions regarding any of the information contained herein may be directed to the Financial Management Branch, National Cancer Institute, 9000 Rockville Pike, Bethesda, Maryland, 20892. TABLE OF CONTENTS Page Organization Director's Biography ........................................ 1 Former Directors of the NCI .................................. 2 National Cancer Advisory Board .............................. 3 Division Boards of Scientific Counselors ........................ 4 President's Cancer Panel .................................... 5 Executive Committee Members ............................... 5 Organization Charts: National Cancer Institute ................................... 6 Office of the Director ...................................... 7 Division of Basic Sciences .................................. 8 Division of Clinical Sciences ................................ 9 Division of Cancer Epidemiology and Genetics ................. 10 Division of Cancer Prevention and Control .................... 11 Division of Cancer Treatment, Diagnosis and Centers ............ 12 Division of -
Ed 376 019 Title Institution Pub Date Note Available From
DOCUMENT RESUME ED 376 019 SE 053 531 TITLE Grants for Science Education, 1992-1993. INSTITUTION Howard Hughes Medical Inst., Chevy Chase, MD. Office of Grants and Special Programs. PUB DATE 93 NOTE 141p. AVAILABLE FROMHoward Hughes Medical Institute, Office of Grants and Special Programs, 4000 Jones Bridge Road, Chevy Chase, MD 20815-6789. PUB TYPE Guides Non-Classroom Use (055) EDRS PRICE MF01/PC06 Plus Postage. DESCRIPTORS *Biomedicine; *Grants; Higher Education; *Research; *Science Education; Secondary Education ABSTRACT To help strengthen education in medicine, biology, and related sciences, the Howard Hughes Medical Institute (HHMI) launched a grants program in these areas in 1987. The grants support graduate, undergraduate, precollege and public science education, and fundamental biomedical research abroad. This document provides summaries of all projects receiving grants in 1992 and is also, in effect, a 1992 annual report for each Programmatic Area supported by HHMI. (ZWH) *********************************************************************** * Reproductions supplied by EDRS are the best that can be made from the original document. *********************************************************************** 9- -.I I, .10 It vr .. * ie Ar -4",_ -7 \---(_,- 1 a Si It I 1 a a I tIt "PERMISSION TO REPRODUCETHIS U S DEPARTMENT OF EDUCATION GRANTED BY Orrice of Educahona, Research and irnomvernent MATERIAL HAS BEEN EDUCATIONAL RESOURCES INFORMATION CENTER (EPICI U ER-P,C This document has been reproduced as owed Iron the person or Organitation originating it C.1 Minor changes name been made to improve reproduction quality TO THE EDUCATIONALRESOURCES Ponis of vev, o ot),n(Ons staled .nlh'S doc 0 meal do not necessarily represent othc,a1 INFORMATION CENTER (ERIC) OE RI pc on or policy I I I a I -SET COPYAWAt'tMI 2 Copyright ©1993 by the Howard Hughes Medical Institute Office of Grants and Special Programs. -
Profile of Nahum Sonenberg PROFILE Ann Griswold, Science Writer
PROFILE Profile of Nahum Sonenberg PROFILE Ann Griswold, Science Writer Five years after the final shots of World War II rang out, a child and his father stood on the coast of the Mediterranean Sea. From their vantage point in a cemetery in the town of Jaffa, Israel, the boy gazed across the sea and envisioned stepping onto the sands of a distant shore. He pointed to the horizon and asked his father what lay beyond. “I remember my father said, ‘There is America, the country where everything is possible,’” says Nahum Sonenberg, the Gilman Cheney Professor of Biochem- istry at McGill University in Montreal. Sonenberg, elected as a foreign associate to the National Academy of Sciences in 2015, has spent nearly five decades looking beyond the horizon to map un- explored territory in molecular biology. His research has uncovered the cellular control knobs of protein synthesis and revealed how this process drifts off-course in cancer, obesity, diabetes, and neurological diseases. His achievements have garnered numerous hon- ors. Sonenberg is a fellow of the Royal Society of London and Canada, Foreign Member of the Amer- ican Academy of Arts and Sciences and the American Association for the Advancement of Science, Asso- ciate Member of European Molecular Biology Orga- nization, and an Officer of the Order of Canada. He has received numerous prizes in the biological sciences, including the Lewis S. Rosenstiel Award for Distin- guished Work in Basic Medical Science, the Wolf Prize, and the Gairdner Foundation International Award. Nahum Sonenberg. Image courtesy of Howard Hughes Medical Institute. Life in Transition Sonenberg’s childhood unfolded in the aftermath of By the time Sonenberg turned 10, he and his family had World War II. -
The Magic Is the Protein.’’ Don’T Wait a Lifetime for a Decision
Vol. 19 / No. 4 / April 2020 THE MEMBER MAGAZINE OF THE AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY ‘‘ The magic isn’t the squid… The magic is the protein.’’ Don’t wait a lifetime for a decision. C. elegans daf-2 mutants can live up to 40 days. JBC takes only 17 days on average to reach a fi rst decision about your paper. Learn more about fast, rigorous review at jbc.org. www.jbc.org NEWS FEATURES PERSPECTIVES 2 22 37 EDITOR’S NOTE ‘THE MAGIC ISN’T THE SQUID ... USE THE MIC! Caution: Tchotchkes at work The magic is the protein.’ 38 3 28 WHAT CAN YOUR OMBUDS OFFICE MEMBER UPDATE ‘START SIMPLE. IT ALWAYS GETS DO FOR YOU? MORE COMPLICATED.’ 6 A conversation with Paul Dawson IN MEMORIAM 10 ANNUAL MEETING RETROSPECTIVE Marilyn Farquhar (1928 – 2019) 32 MOLECULAR & CELLULAR PROTEOMICS SESSION 13 LIPID NEWS 32 A deeper insight into phospholipid MCP TO HOST PROTEOMICS SESSION biosynthesis in Gram-positive bacteria 33 GINGRAS STUDIES PROTEOMICS’ IMPLICATIONS FOR RESEARCH 14 34 JOURNAL NEWS SELBACH SEEKS THE SCIENCE BEHIND THE MAGIC 14 Scrutinizing pigs’ biggest threat 35 15 Progesterone from an unexpected source GARCIA USES MASS SPECTRONOMY TO UNRAVEL THE HUMAN EPIGENOME may affect miscarriage risk 16 Finding neoantigens faster — advances in the study of the immunopeptidome Don’t wait a lifetime for a decision. 18 From the journals C. elegans daf-2 mutants can live up to 40 days. JBC takes only 17 days on average to reach a fi rst decision about your paper. Learn more about fast, rigorous review at jbc.org. -
“Global Health Research”?
32 International Health: Feature Article Volume 3 No. 1, 2006 INTERNATIONAL HEALTH: FEATURE ARTICLE What is Canada Doing About “Global Health Research”? Vic Neufeld, MD, FRCPC ABSTRACT The worldwide investment in health research is currently about US$100 billion. Of this amount, less than 10% is targeted on the problems of societies that bear 90% of the global burden of illness. This article addresses this unac- ceptable situation in three ways: • by describing the global problem in more detail, including what is currently being done about it; • by summarizing Canada’s contribution to resolving the problem, both through federal government agencies, and through a new non-government organization: the Canadian Coalition for Global Health Research (CCGHR); • by suggesting what Canadian university students might consider doing about it. This includes getting informed, getting involved, and considering “global health” as one component of their future careers. The article concludes with the conviction that this is a remarkable moment for Canadians to play a more active role in global health—and indeed in global citizenship more broadly. WHAT IS CANADA DOING ABOUT “GLOBAL about the fact that research efforts to address this burden HEALTH RESEARCH”? appeared to be too small and ineffective. A major 2-year study was undertaken by the Independent International Commission n 2002, the worldwide investment in health research was on Health Research for Development (CHRD). The about US$100 billion. It is a startling fact that of this Commission released what has become a landmark report in Iamount, less than 10% was directed to research on problems 1990.1 Among its findings, the CHRD reported that about 93% of societies that bear 90% of the global burden of illness.