Origins: Shou Shi Bao Yuan by Gong Ting-Xian, Eight Immortals Formula Ba Xian Chang Shou Wan Ming Dynasty, 1615

Eight Immortals Formula (Ba Xian Chang Shou Wan also known as Mai Wei Di Huang Wan ) is a Ming Dynasty formula first published inShou Shi Bao Yuan (Achieving Longevity by Guarding the Source). It is a modification of the famous 12th century formula, Rehmannia Six Formula (Liu Wei Di Huang Wan). General Signs/Symptoms Eight Immortals Formula (Ba Xian Chang Shou Wan) was designed to address chronic disorders and aging marked by significant yin deficiency in the lungs and kidneys. Signs and symptoms that distinguish the pattern include chronic dry, weak cough with possible blood-tinged expectoration, weak cough with scant sticky phlegm, shortness of breath, asthma or wheezing, chronic laryngitis from dryness, frequent urination, impotence or premature ejaculation, chronic nephritis, shortness of breath, asthma, or wheezing, diabetes. The primary pattern signs and symptoms will be accompanied by typical yin deficiency pattern signs and symptoms such as weakness in the lower body, tidal fever, dry mouth, dry skin, dizziness, night sweats, hot palms and soles, or tinnitus. Classical Applications 1.Supplements 2. Supplements 3. Astringes lung 4. Generates 5. Clears heat kidney qi and lung and qi and kidney fluids, moistens yin stomach yin essence dryness

Ingredients Pinyin Latin English Percent of Formula Sheng Di Huang (chief) Rehmanniae (radix) Rehmannia root, unprocessed 17.7% Mai Men Dong (co-chief) Ophiopogonis (radix) Ophiopogon tuber 11.0% You Gua Shi Hu (deputy) Dendrobii (herba) Chinese Orchid, Dendrobium 8.9% Shan Yao (deputy) Dioscoreae (rhizoma) Chinese Yam 8.9% Shan Zhu Yu (deputy) Corni (fructus) Asiatic Dogwood fruit, Cornelian Cherry 8.9% Yu Zhu (deputy) Polygonati odorati (rhizoma) Aromatic Solomon’s Seal 8.9% Bei Sha Shen (deputy) Glehniae (radix) Glehnia root 8.9% Wu Wei Zi (deputy) Schisandrae (fructus) Schisandra fruit 6.7% Ze Xie (assistant) Alismatis (rhizoma) Asian Water Plantain rhizome 6.7% Mu Dan Pi (assistant) Moutan (cortex) Tree Peony root bark 6.7% Fu ling (assistant) Poria Poria, Hoelen, Tuckahoe 6.7%

General Indications / Modern Applications • Appetite, lack of • Ejaculation, premature • Peri-menopausal syndrome • Asthma • Fatigue and generalized • Pulmonary tuberculosis • Atopic dermatitis weakness in elderly • Ringing in the ears • Complexion, lusterless • Fever, tidal • Seminal loss • Constipation, from dryness • Hoarseness, dry-type • Steaming bones • Cough, dry, weak, with scant, • Impotence • Tinnitus sticky phlegm • Incontinence, urinary • Tuberculosis, pulmonary • Coughing up blood • Laryngitis, from dryness • Urination, frequent • Diabetes mellitus • Nausea • Vertigo • Dizziness • Nephritis, chronic • Vision, blurred • Dry mouth and throat • Night sweats • Wheezing • Dry skin • Palms and soles of feet hot • Dyspnea/ shortness of breath • Palpitation

Eight Immortals Formula Monograph © January 2013, Herbal Medicine Press Eight Immortals Formula 2 three times daily. Standard dosage two is tablets, taken D Huang Wan) Scrophularia Formula deficiencyyin use deficiencyfire oflung without signs viral infection. In with yin cases or external cold or during an acute internalDo of notcases in use C positions. thein Fine and rapid, or large and empty P possibly geographic. small. scant Coat be or will absent, red, be will Body shiny, and maybe T • Clears heat • Generates fluids, moistens • Astringes lung qi and kidney • Supplements lung and stomach • Supplements kidney qi and yin F ongu ormula uls ontraindi osage dryness essence yin e cun e

A (inch) and/or c c tions ations instead. Rehmannia & /C autions

(Zhi Bai Di Bai Di (Zhi chi chi (cubit) of the kidney andof lung, fresh rehmannia ( sence) from the lungs and kidneys. Since this formula treats adual deficiency yin on nourishing lung and stomach yin, and preventing further qiand es leakage (of The five additions to form when treating damage to the lungs or kidneys from chronic fire. yin differences action makefresh of rehmannia more appropriate than its prepared fresh rehmannia ( and yin primarily fluid; body of and though it does not really supplement blood, fresh rehmannia ( fresh rehmannia ( heat. It commonly is combined with herb, the chief fresh rehmannia ( and stomach, generates fluids, supports kidney essence, anddrains deficiency dendrobiumis ( finalThe of substance sinews to facilitate the heat expulsion and pathogens. of stomach, but the in sinews. It the has ability to nourish the interstitial the fluid of lygonatum ( the lungs, and can therefore venting assistin lingering pathogens the in lung. Po ophiopogon ( ate fluids, by which actions they as seendeputiesbe can serve to to the co-chief, and polygonatum ( substances from Glehnia and Ophiopogon Decoction, glehnia root ( dong external dryness the in autumn. We have already ophiopogon discussed ( Dong Tang menting substances Glehnia and Ophiopogon of Decoction ( here,discussion along with ophiopogon ( Two the other of three substances included the in version the formula of under deputy in relation to both the chief and co-chief. to restrain and astringe outweigh its ability to supplement, it takes the position of lung and kidney to supplement the deficiencies theof pattern. But since its ability might be considered the sole chief, since it is the only substance that enters both the nature schisandra of ( sweetness and warmth, the prevailing sour flavorastringes and restrains. This is the yin organs to supplement and harmonize, but after penetrating the zang with ing action is supplementing and restraining. Being also sweet and warm, it enters fluence on the kidney, heart, and lung. The prevailing flavor is sour and itsprevail this is not really the case. Though able to enter all five believe that schisandra ( theof mulation. It is notable for possessing five flavors One the of deputies, schisandra fruit ( can cool the upper warmer, calm irritability, and clear heat. moisteninghas actions for the heart and the intestines and, being cold-natured, primarily moistens lung and stomach and yin generates fluids, body but it also this fills role by adding ophiopogon ( because it not does enter the lung channel. required, is A co-chief and Gong ful ( nia substitution ingredient the chief acommon of is one. Whereas prepared rehman ( GongTing-Xian’s “eight” three additional substances: aromatic solomon’s seal dongmen the number eight included the the in formula): name of ophiopogon root ( Wan the tonics, yin most famous of Eight Immo Synergy of Ingredients yu zhu yu shu di huang ). In ). The original modification added two substances (which accounts for zang ), dendrobium ( ) and schisandra fruit ( Eight Immortals Formula ), aformula designed to expel, protect against, and repair damage from organs, plus the stomach yu zhu yu rtals Formula mai dong men shi hu ) supplements both and yin blood, slightly it is warming. While sheng di huangsheng di huangsheng di huangsheng ) supplements and yin generate fluids, not onlyin the lung and yu zhu yu Liu Wei Huang Di Wan ). Dendrobium ( Eight Immortals Formula shi hu wu wei zi wu wei zi ), enter the lung and stomach, nourish and yin gener

). Glehnia root ( (Ba Xian(Ba Shou Wan) Chang ), and glehnia root ( Rehmannia Six Formula ) can enter the blood level to drain heat. These ), contrast, in is cold,”“very its supplementation is ) for the prepared rehmannia ( wu wei zi wei wu ) has an unusually broad scope actions, of but ). In the present formula, schisandra ( fu (Ba Xian(Ba Shou Wan) Chang mai dong men wu wei zi . The variety theof flavors may lead one to shi hu mai dong men ). The present formulation adds to sheng di huangsheng bei shashen bei ) supplements the the kidney of yin concentrate the formula’s actions ), is also from Gong’s original for (wu wei) bei shashen bei ( ). Ophiopogon ( Ba XianBa Shou Wan Chang zang ) are the supple mainyin ) has an action) has to dredge is aformula is built upon ) cannot rule by itself, and said to enter all five ( , it has the strongest in Liu Wei Huang Di ). It substitutes also Sha Shen Mai Shen Sha Men shu di huang , the other two mai dong men bei shashen bei sheng di sheng wu wei zi mai men mai ). This ) - - - - - ) - - - ) - ) Eight Immortals Formula 3 ------Eight Eight Liu Wei Di Wei Liu may be an may . This qi acts qi This . ), was found to to was found ),

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More details of this relationship are required in required are details of relationship this More it. grasp to able is this accomplished. how appreciate to order store the qi from heaven if the lung cannot descend it. For the the For it. descend if cannot lung heaven the qi from the store lung the kidney, and lung the between work to qi mechanism be to needs kidney the and qi the descend to be able to needs ceives the breath” as well as “stores the qi from heaven.” The lung lung The heaven.” qi from the “stores as as well breath” the ceives the from support without govern to strength the will have not yuan The lung-kidney relationship is defined by yin and qi. In the qi In and qi. by yin defined is relationship lung-kidney The of qi” the governor “the is lung the aspectof relationship, this “re of root qi,” “the is kidney the but breath,” the “controls and as thirst, dry mouth, hoarse voice, weakness in the lower body, body, lower in the weakness voice, hoarse dry mouth, as thirst, dry skin, dry mouth, bones, steaming fever, tidal sweats, night soles. palms and hot or dizziness, When When will present patient the conditions, these treat to is indicated such symptoms signs and with constitution a yin deficient with tidal fever or night sweats, symptoms of diabetes mellitus with of with mellitus diabetes symptoms sweats, night or fever tidal fatigue or weakness generalized yin consumption, warmer upper semen. retain to inability and impotence intake, food low with Formula Discussion Formula Formula Immortals Eight chronic asthma, or cough chronic treat to used today primarily disease, and with glehnia ( glehnia with and disease, dong huang Eight Immortals Formula 4 nourish lung qi, lung yin, stomach yin and moisten dryness. There These two formulas have a few actions in common: the ability to Eight Immortals Formula and Sheng Mai Formula Immortals Formula Preserve Metal Formula dryness. Transformation addressed phlegm is the of in thick and difficult to expectorate due to yinthe deficiency causing sputum and wheezing cough. The sputumis probably that are primarily lung related unresolved but has also phlegm Hu Gu Jin Tang) The patient for whom the glossy, with no coat and may dryness and show cracks. of signs and may include five palm heat. The patient’s tongue bemay red, dryness. The tidal fever symptoms maybe more pronounced throat and skin, stool, dry bronchial or laryngeal condition from dry, raspy cough, coughing up blood from dryness, mouth, dry symptomshas dryness and heat of from deficiency yin suchas: dryness. The patient that would mostbenefit fromthis formula thehas ability to nourish stomach deficiency yin and moisten each. andyin stop cough. There aresome differences of in theactions twoThese formulas have the ability to nourish lung and kidney Eight Immortals Formula and Lily Preserve Metal Formula Formula Comparisons Shou Wan and qideficiency, ficiency,liver qi stagnation thatoccasionally resultsliverin fire, making decisions. When the TCM kidney de yin is diagnosis ache, tiredness, concentration, insomnia, lack of and difficulty primary symptoms are: depression, tearfulness, irritability, head women,by middle-aged prior menopause. to the of onset The nese term referring symptoms to of aset sometimes experienced “Autumn Flower Syndrome” the is English translation aChi of Peri-Menopausal Syndrome pattern. thement disease of tals Formula lung and kidney deficiency, yin with qi deficiency, cough and bronchitis. When the primary symptoms indicate COPD (chronic obstructive pulmonary disease), chronic asthma, iv iii ii E v improvement resistance insulin of fructose-rich in chow-fed rats, 2113, 2008. atopic dermatitis- like skin lesions induced by mite antigen NC/Jic in Mice, i Hsu, J., Wu, Y., Liu, I., Cheng, J., Dioscorea the as principal Die-Huang-Wan, herb of awidely herbal used mixture for China, in ndnot

Sordyl, A., How to treat lower respiratory with tract the disease KISSprinciple, deficiency withdamage to thezangfu. deficiency forgetfulness andamnesiadueto marrow andessence This isausefulcombination to treat brain atrophy, For yinandyang deficiency impotence withbothkidney Tang, S.L., Autumn Flower Syndrome, Makino, T., Hamanaka, M., Yamashita, H., Mizukami, H., Effort Bakumijiogan, of an herbal formulain traditionalChinese medicine, on Liu, C., Tseng, A., Yang, S., Herbal Chinese Medicine Modern Applications of Traditional Formulas, CRC Press, p. 541, 2004. Eight Immortals Formula es ) may the be most appropriate formula. ( Ba XianBa Shou Wan Chang would most be appropriate symptoms has Eight Immortals Formula ( Ba XianBa Shou Wan Chang

(Bai Hu(Bai Gu Jin Tang) Lily Preserve Metal Formula 3

( Ba XianBa Shou Wan Chang Journal Association ofthe ofTraditional Chinese Medicine ) is suggested) is for treat v ( Ba XianBa Chang ). but not in Eight Immor 4

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(Bai (Bai Eight ) also ) also Journal ofEthnopharmacology, - - - - - Use with Use with resulting from stress and overwork, and nourish liver yin. A FormulaQi depleted through excessive work, stress, or sexual activity. Jing Pian) Qi ( As the name indicates, the primary of focus yin, though the other the formulas actions of are quite different. These formulasboth support nourishment kidney qi and of Eight Immortals Formula wei leading to significant overall weakness and fatigue and weakened depletes the bodily fluids and saps the strength the of heart, weak leading to profuse, spontaneous sweating. This further congestive heart failure. The patient’s sputum. This pattern may also involve the heart organ,as in dry and weak or there may be very dry, difficult to expectorate productive cough in order to clear their lungs, so the cough is very is most appropriate, is very likely too weak to even mount a “Generate the Pulse Powder”. The person for which this formula be quite weak, thus the English translation of theof lungs, and is in a very weakened state. The pulse would patient, one who has exhausted the bodily fluids, the yin and qi Mai(Sheng San) are a number significant of differences. Shou Wan directly,yin does as cystitis due to inflammation. This formuladoes not addresslung fire, anddry sore throat, andpossibly urinarydifficulty, UTI or tidal fever, hot flashes, restlessness, toothachefrom deficiencyyin dizziness or vertigo due to fire, red face, lowgrade afternoon or patient presents with deficiency yin fire symptoms such as ( their similarity ends. twoThese formulasboth nourish kidney yin, but is wherethis Formula Eight Immortals Formula and Rehmannia &Scrophularia Shou WanChang dryness are present, then and presentation pulse deficiency heat butsymptoms if and patient may present with similarindications and asimilartongue Zhi Bai Di Huang Bai Di Zhi Wan) Biological Bulletin Pharmaceuticals qi defenses. Journal ofChinese Medicine Restore Kidney theLeft Pill Vital Treasure Formula ). Jing Pian) Qi ( is to is support kidney

is intended for use with a much more deficient ) is more) is appropriate. Vol. 112, pp. 577-584, 2007. Eight Immortals Formula , Vol. 16, Issue 1, March 2009. Rehmannia and Scrophularia Formula Eight Immortals Formula would the be ideal formula the if can move also liver qistagnation,

and Jing Formula Qi , Vol. 77, pp. 46-52, 2005. , Vol. 31, Issue 11, pp. 2108- (Zhen BaoFang) jing wei ( (essence) that been has Sheng Mai Formula Zuo GuiWan qi may be excessively Jing Formula Qi Sheng Mai San ( Ba XianBa Chang . ). ( Ba XianBa Jing

is