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The Diverse Applications of Mass Spectrometry THE DIVERSE APPLICATIONS OF MASS Brought to you by SPECTROMETRY See what you’ve been missing MAM WORKFLOW BV Track Quantify Purity New Peaks Report Streamlined and The powerful yet straightforward SCIEX Workow for MAM in Complete Workow the BioPharmaView™ Software 3.0 offers a single software solution for simplied PQA denition, monitoring, quantitation, for Multiple Attribute impurity testing and reporting. Methodology (MAM) • Directly detect and measure biologically relevant attributes using LC-MS with high-resolution LC-MS • Easily create customized calculations and attribute Learn More > acceptance criteria for accelerated data review • Track known variants or impurities Detect and ag the presence of unspecied impurities Biologics Analysis by CESI-MS Learn More > CESI-MS is used by BioPharma Leaders for the analysis of intact biologics such as monoclonal antibodies (mAbs) and Erythropoietin (EPO), peptide mapping, disulfide mapping, identification of post-translational modifications and antibody drug conjugates (ADCs). • Intact proteins: accurately characterized for product quality and purity • Peptide mapping: 100% coverage and PTMs from one digest and one analysis AB Sciex is doing business as SCIEX. © 2018 AB Sciex. For research use only. Not for use in diagnostic procedures. The trademarks mentioned herein are the property of the AB Sciex Pte. Ltd. or their respective owners. AB SCIEX™ is being used under license. Related to RUO-MKT-03-7587-A and RUO-MKT-13-7803-A The Diverse Applications of Mass Spectrometry Foreword In today’s world, the diversity of mass spectrometry instrumentation and applications thereof is simply mind-boggling. The mid to late 19th century heralded the emergence of the concept that later led to the development of mass spectrometers that could physically ‘weigh’ the mass of a molecule. Over the last 150 years, this analytical instrumentation has developed into Contents the fascinating and remarkably diverse field of mass spectrometry (MS) with practical, modern- day applications covering a myriad of topics. MS is used in forensics and anti-terrorism to How Mass Spectrometry Has Changed analyze chemical warfare agents and explosives. the Cancer Diagnostics Game 4 These not only pose immediate danger to the safety and well-being of people; but can How to Test for Heavy Metals in Cannabis 6 have long-term hazardous implications for humankind, wildlife and the ecosystem. MS Steve Pennington on 10 Years of also aids in monitoring drug abuse by assisting Proteomic Progress 8 law enforcement in the rapid detection and identification of designer drugs and narcotics; Rapid Detection of Designer Drugs and plays a key role in maintaining societal Presents Challenges for Law Enforcement health by evaluating and ensuring the safety of food and beverages. Similarly, in the medicinal and Forensic Toxicology 10 plant industry, heavy metal levels in cannabis are monitored by MS to guarantee the continued How Advances in Mass Spectrometry Are well-being of patients. Helping the Food and Beverage Industry 12 MS furthers our access to new, innovative Measuring How the Brain Metabolizes therapeutic approaches to diagnose, monitor and treat disease. Applications include real-time in Real-time 15 monitoring of brain cell metabolism in animals for toxicological profiling and drug discovery. Other Mass Spectrometry’s Important Role in advances in MS not only provide information on Identifying Explosives in the Environment 17 higher-order protein structure, contaminating proteins and the in vivo behavior of emerging Mass Spectrometry in biotherapeutics; but also, on the efficacy and Biopharmaceutical Discovery 20 safety of these drugs. Furthermore, MS is used to understand aberrant signaling pathways Helping Analytical Chemistry Embrace Big for drug development, or to identify molecular Data 23 signatures from the circulating proteome of a patient that can be exploited to overcome Developing FTICR Mass Spectrometry treatment resistance and relapse. Indeed, MS Instruments with Unique Capabilities 25 can now even guide surgeons in real-time to precisely resect cancerous tissue. This eBook highlights the broad spectrum of applications that integrally utilize mass spectrometry. Such a powerful technique now spans diverse fields and has an extensive and far-reaching impact on society. The Diverse Applications of Mass Spectrometry MasSpec Pen Detects Cancer in Seconds and How Mass One-ups the iKnife A hand-held device that connects to a mass spectrometer and Spectrometry identifies cancerous tissue during surgery hit the headlines last year, claiming to deliver results in ten seconds. Termed MasSpec Pen, the device contains a probe that can soak up molecules Has Changed from human tissue and send to a mass spectrometer wheeled into the surgery room. Within a matter of seconds, molecular the Cancer analysis by an ambient ionization MS technique indicates which areas of tissue are cancerous and should be removed by surgery. Diagnostics The device can also sample tissue non-destructively, offering an advantage over a similar device called iKnife that causes tissue Game damage due to electrocauterization. Charya Wickremasinghe, PhD In a test of 253 patients with lung, breast, thyroid or ovarian cancer, the MasSpec Pen was able to provide a tissue diagnosis with over 96 percent accuracy. Even in marginal regions that ith a history that spans one hundred years, mass contained mixed tissue and cellular compositions, the device was spectrometry (MS) is one of the most widely used able to detect cancer. Wanalytical techniques in bioscience and medical research. Since the development of the first modern mass During development, researchers used a benchtop liquid spectrometer in 19181, the technique has advanced steadily over chromatography-tandem mass spectrometry (LC-MS/MS) time and found its way into a range of applications from forensic system with quadruple precursor ion selection, and high- toxicology to cancer diagnostics. Bulky, expensive equipment resolution, accurate-mass (HRAM) Orbitrap detection.2 Since that defined historical mass spectrometers are less common this is a large instrument that takes up considerable space in now, and have been replaced by faster, more sensitive, and the surgery room, developers are already looking into getting cost-effective workflows. Newer spectrometers are also largely reliable data from a more compact spectrometer. automated and user-friendly, making them more adaptable for clinical use. Using Quantitative MS to Help Guide Lung Cancer Therapy Although histopathology is still the gold standard for diagnosing cancer, molecular analysis using MS has gained traction in the A team of researchers at the Virginia Commonwealth recent years for detecting tumors, monitoring progression, and University lead by Professors Adam Hawkridge (Department even predicting treatment response. of Pharmaceutics, School of Pharmacy) and David Gewirtz (Department of Pharmacology and Toxicology, School of Technology Networks 2018 4 TechnologyNetworks.com The Diverse Applications of Mass Spectrometry Medicine) are utilizing quantitative mass spectrometry to Scientists at Biodesix input data acquired from Matrix Assisted uncover clues related to treatment resistance and relapse of non- Laser Desorption/Ionization Time-of-Flight (MALDI-ToF) small cell lung cancer (NSCLC). mass spectrometry into a machine learning platform for multivariate test design.4 “MALDI allows us to take a real-time “Mass spectrometry can be used on a number of levels to better snapshot of a patient’s circulating proteome, which is derived understand NSCLC signaling pathways for drug development, from the tumor, tumor microenvironment, and normal host or to identify molecular signatures that can be exploited to tissue. These proteins have direct regulatory effects on the overcome NSCLC treatment resistance,” says Hawkridge. “For immune system, especially the interplay of the innate and example, in our most recent LC-MS/MS study of treatment adaptive system,” Röder explains. “We do not need to choose resistance, we found that senescence – rather than autophagy proteins based on pre-conceived notions of relevance, as one has – associated proteins were more prominently secreted in the to do in fixed panel approaches, and hence can observe effects treatment resistant-cells in response to ionizing radiation.” that are often missed.” In a previous study by Hawkridge’s team, LC-MS/MS analysis Biodesix uses a special MALDI-ToF method for protein analysis, allowed the identification of 364 secreted proteins that could be termed Deep MALDI™, which is aimed at reducing the noise further studied for their potential diagnostic value as a function in mass spectral data by increasing the number of laser shots. of p53 expression, irradiation, and functional autophagy status “With this method, we can measure more proteins in a robust in the context of NSCLC.3 The lead author of the study, Dr. and reproducible way with a high sample throughput and small Emmanuel Cudjoe, explained that cancer cells respond to stress sample volume,” says Röder. “We also experience a much wider by activating a process called autophagy in which organelles are coverage of reliably detectable proteins and peptides compared recycled and energy production is maintained, leading to tumor to traditional MALDI-ToF.” growth, therapeutic resistance and relapse. Although Deep MALDI can function across an abundance “Where autophagy contributes to treatment resistance, inhibition range of
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