11Th North American FT MS Conference Program

Total Page:16

File Type:pdf, Size:1020Kb

11Th North American FT MS Conference Program Florida State University 1800 East Paul Dirac Drive Tallahassee, Florida 32310 nationalmaglab.org 12 April 2017 Colleagues, On behalf of the National High Magnetic Field Laboratory and Florida State University, we welcome you to the 11th North American FT MS Conference! We hope that your stay in Key West will be personally and professionally rewarding. Topics span a broad range of techniques and applications. Posters will remain up throughout the meeting, to encourage discussions. The primary effort for organizing this conference has been provided by the conference coordinator, Karol Bickett. She has done an excellent job with the many required logistical and personal arrangements. Your registration fee covers only part of the expenses of this conference. The generous contributions of our sponsors have kept the meeting costs affordable for participants, and made it possible for us to assist with the expenses of the invited speakers and the numerous graduate student poster presenters. Please take an opportunity to thank our participating sponsors at their display tables. Thank you for joining us, and we look forward to a splendid conference! Sincerely, Christopher Hendrickson Director, Ion Cyclotron Resonance Program, NHMFL Christopher Hendrickson, Director, ICR Program 850.644.0711 | [email protected] Operated by Florida State University, University of Florida, and Los Alamos National Laboratory Supported by the U.S. National Science Foundation and the State of Florida 11th North American FT MS Conference Table of Contents Page # Welcome Letter 1 Table of Contents 2 Sponsors 3 General Information 4 Plenary Speaker Bio 5 Conference Schedule 6 Speaker Abstracts 11 Vendor Talk Abstracts 39 Student Award Abstracts 41 Poster Abstracts 56 Participant List 70 Notes 77 Author List 80 2 11th North American FT MS Conference THANKS TO OUR SPONSORS Platinum Sponsors National High Magnetic Field Laboratory https://nationalmaglab.org ExxonMobil www.exxonmobil.com ThermoFisher Scientific www.thermoscientific.com Bruker Corporation www.bruker.com Silver Sponsor Advion, Inc. www.advion.com 3 11th North American FT MS Conference General Information • Name tags must be worn at all times during the conference, including the oral sessions, the poster sessions, all mixers, all breaks and all meals. • Paid accompany guests are welcome to the opening mixer, the dinner Monday night and the banquet dinner Wednesday night. Name tags must be worn at these events. • Oral and poster sessions will be held in the Flagler Ballroom. • Please see conference program agenda for location of meals and breaks. • This is a non-smoking facility. Smoking is not permitted inside the buildings. • Photography is not permitted at the oral or poster sessions. • All cell phones must be turned off or set to vibrate during all oral sessions. Courtesy is expected. • A message board is located by the conference registration table. • Posters may be set up beginning on Sunday, April 23rd between 5:00 p.m. and 10:30 p.m. All posters should be in place by Monday, April 24th at 5:00 p.m. Posters must be removed no later than Wednesday, April 26th at 1:00 p.m. Please see the conference program for the appropriate poster number. Any posters remaining after 5:00 p.m. on Wednesday, April 26th will be discarded. • Speakers may review talks prior to sessions. Please see Greg Blakney as early as possible but, no later than, one session break prior to your scheduled talk. If you are the first talk in the morning, please see Greg the evening prior. • There is wireless available in the hotel. No password is required. Additionally, there is hard wired internet in the lodging rooms. • Those leaving early from the conference, but after hotel check out, may store their luggage with hotel bell staff. • Downtown shuttle from the hotel begins at 8:00 a.m. and every hour on the hour and drops off at Margaritaville and at the Butterfly Conservatory. Return from Margaritaville to the hotel at 20 past every hour. Last shuttle return from Margaritaville is at 11:20 p.m. 4 11th North American FT MS Conference Plenary Speaker Donald F. Hunt Donald F. Hunt is a University Professor of Chemistry and Pathology at the University of Virginia and pioneered efforts to develop methods and mass spectrometry instrumentation that set the standard for ultrasensitive detection and characterization of proteins and peptides. These contributions continue to underpin the whole field of proteomics and have had a dramatic impact on research in immunology, cell signaling, cell migration, chromatin biology and immunotherapy of cancer. He is a Fellow of the American Academy of Arts and Sciences and a consultant to Thermo-Fisher Inc. He has a Google Scholar h-index of 106 and an i10-index of 320. Don obtained his B.S. in Chemistry at the University of Massachusetts and, earned his Ph.D. in Organic Chemistry from the University of Massachusetts. He joined the University of Virginia in 1968 and has been a Visiting Professor at Cambridge University and at Imperial College of Science and Technology in England. 5 11th North American FT MS Conference KEY WEST MARRIOTT BEACHSIDE HOTEL Key West, Florida April 23 – 27, 2017 Conference Program Sunday 5:00 p.m.-10:30 p.m. Registration – Flagler Foyer April 23 Session I. Flagler Ballroom 7:25 p.m. Welcome: Alan Marshall National High Magnetic Field Laboratory/Florida State University 7:30 p.m. Don Hunt University of Virginia “Instrumentation and Methods for the Identification and Sequence Analysis of (1) Intact Proteins and Large Fragments on a Chromatographic Time-Scale and (2) Tumor Specific Post- Translationally Modified MHC Peptides for Immunotherapy of Cancer” (There will be a mixer following in the Flagler Terrace/Foyer) Monday 8:00 a.m. - 8:55 a.m. Breakfast – Flagler Terrace/Ballroom April 24 Registration Open – Flagler Foyer Session II. Flagler Ballroom 9:00 a.m. Richard Caprioli Vanderbilt University “Imaging Mass Spectrometry: Molecular Microscopy for Biology and Medicine” 9:30 a.m. Michael Gross Washington University “Chemical Footprinting and FTMS Bottom-Up Analysis for Membrane Protein Analysis” 10:00 a.m. Caroline DeHart Northwestern University "A Multi-Modal Proteomics Strategy for P53 Modform Characterization" 10:30 a.m. Break – Flagler Foyer/Terrace 6 Session III. Flagler Ballroom 11:00 a.m. Evan Williams University of California, Berkeley “Mass, Mobility and MSN Measurements of Individual Ions Using Charge Detection Mass Spectrometry” 11:30 a.m. Jon Amster University of Georgia “Nadel-Cell Behaviors Studied Using Particle-In-Cell Simulations” 12:00 p.m. Nathalie Agar Harvard Medical School “Mass Spectrometry for Image Guided Neurosurgery and Drug Development” 12:30-1:30 p.m. Lunch – Flagler Terrace/Ballroom Session IV. Flagler Ballroom 1:30 p.m. Lissa Anderson National High Magnetic Field Laboratory “Advancing Intact Protein Analysis Through Instrumentation and Data Acquisition Method Development” 2:00 p.m. David Goodlett University of Maryland, Baltimore “Lipid A as a Therapeutic and Diagnostic Target” 2:30 p.m. Thomas Oldenburg University of Calgary “Fuzzy Logic Assisted Compound Assignment Aids in Unravelling the FTMS Spectra of Complex Organic Mixtures from Petroleum Systems and Oceanic Dissolved Organ Matter. Towards Functional Applications of FTMS as a Routine Part of Organic Chemistry” 3:00 p.m. Break – Flagler Terrace 3:30 p.m. Ron Heeren Maastricht University “FTMS and Imaging: Resolving Hidden Features, Isomeric Structures and Disease Dynamics” 4:00 p.m. Jarrod Marto Harvard Medical School “Novel Chemoproteomic Approaches for Proteome-Wide Identification of Covalent Drug Targets” 4:30 p.m. Ashley Wittrig ExxonMobil Research and Engineering Company “Structural Elucidation of Petroleum Ions by CID on a 15T FT-ICR Mass Spectrometer” 6:00-7:15 p.m. Dinner- Flagler Ballroom 7 Sponsor Presentations. Flagler Ballroom 7:15-7:30 p.m. Announcements 7:30-7:45 p.m. ThermoFisher Scientific – Shannon Eliuk “A Simplified Approach to Fast and Accurate, High Throughput Targeted MS2 Quantitation Using Internal Standards” 7:45-11:00 p.m. Poster Presentations Tuesday 8:00 a.m. - 8:55 a.m. Breakfast – Flagler Terrace/Ballroom April 25 Registration Open – Flagler Foyer Session V. Flagler Ballroom 9:00 a.m. Helen Cooper University of Birmingham, UK “In Situ Protein Analysis: Latest Developments in Lesa Mass Spectrometry” 9:30 a.m. Scott McLuckey Purdue University “The Development of Electrostatic Linear Ion Traps as General Purpose Tandem Mass Spectrometers” 10:00 a.m. Jim Bruce University of Washington “Systems Structural Biology and Demands on Mass Measurement Accuracy” 10:30 a.m. Break – Flagler Foyer/Terrace Session VI. 11:00 a.m Chad Weisbrod National High Magnetic Field Laboratory “Mass Spectrometry at 21 T: What We’ve Learned So Far…” 11:30 a.m. Yury Tsybin Spectroswiss “On the Perspectives of FT-ICR MS at the Cyclotron Frequency” 12:00 p.m. Conference Photo on the beach Open afternoon to explore Key West 8 Wednesday 8:30 a.m.-9:25 a.m. Breakfast – Flagler Terrace/Ballroom April 26 Registration Open – Flagler Foyer Session VII. Flagler Ballroom 9:30 a.m. Roman Zubarev Karolinska Institutet “FTMS-Based Proteomics Goes Isotopic” 10:00 a.m. Kristina Håkansson University of Michigan “Tandem Mass Spectrometry Approaches to the Elucidation of Sulfur-Associated Protein Modifications” 10:30 a.m. Francisco Fernandez-Lima Florida International University “On the Coupling of Trapped Ion Mobility Spectrometry and Ultrahigh Resolution of FT-ICR MS” 11 a.m. Break – Flagler Foyer/Terrace 11:30 a.m. student (selected from poster presentations) 11:50 a.m. student (selected from poster presentations) 12:10 a.m. student (selected from poster presentations) 12:30-1:30 p.m. Lunch – Flagler Terrace/Ballroom Session VIII. Flagler Ballroom 1:30 p.m. Ying Ge University of Wisconsin-Madison “Novel Strategies in High-Resolution Mass Spectrometry-Based Top-Down Proteomics” 2:00 p.m.
Recommended publications
  • I HIGH MASS ACCURACY COUPLED to SPATIALLY-DIRECTED
    HIGH MASS ACCURACY COUPLED TO SPATIALLY-DIRECTED PROTEOMICS FOR IMPROVED PROTEIN IDENTIFICATIONS IN IMAGING MASS SPECTROMETRY EXPERIMENTS By David Geoffrey Rizzo Dissertation Submitted to the Faculty of the Graduate School of Vanderbilt University in partial fulfillment of the requirements for the degree of DOCTOR OF PHILOSOPHY in Chemistry August, 2016 Nashville, Tennessee Approved: Richard M. Caprioli, Ph.D. Kevin L. Schey, Ph.D. John A. McLean, Ph.D. Michael P. Stone, Ph.D. i Copyright © 2016 by David Geoffrey Rizzo All Rights Reserved ii This work is dedicated to my family and friends, who have shown nothing but support for me in all of life’s endeavors. iii ACKNOWLEDGEMENTS “As we express our gratitude, we must never forget that the highest appreciation is not to utter words, but to live by them.” - John F. Kennedy – There are many people I must thank for showing kindness, encouragement, and support for me during my tenure as a graduate student. First and foremost, I would like to thank my research advisor, Richard Caprioli, for providing both ample resources and guidance that allowed me to grow as a scientist. Our discussions about my research and science in general have helped me become a much more focused and discerning analytical chemist. I must also thank my Ph.D. committee members, Drs. Kevin Schey, John McLean, and Michael Stone, who have brought valuable insight into my research and provided direction along the way. My undergraduate advisor, Dr. Facundo Fernández, encouraged me to begin research in his lab and introduced me to the world of mass spectrometry.
    [Show full text]
  • Developing Next Generation Technologies for Spatially Targeted
    Developing Next Generation Technologies for Spatially Targeted Proteomics By Daniel Joseph Ryan Dissertation Submitted to the Faculty of the Graduate School of Vanderbilt University in partial fulfillment of the requirements for the degree of DOCTOR OF PHILOSOPHY in Chemistry June 30th, 2019 Nashville, Tennessee Approved: Richard M. Caprioli, Ph.D. Jeffrey M. Spraggins, Ph.D. John A. McLean, Ph.D. Lars Plate, Ph.D. Kevin L. Schey, Ph.D. Copyright © 2019 by Daniel Joseph Ryan All Rights Reserved ii ACKNOWLEDGEMENTS It is with the help of many people that I am afforded the unique privilege of being able to sit here and write out an acknowledgements section for my dissertation. First and foremost, I would like to thank both of advisors, Dr. Richard Caprioli and Dr. Jeff Spraggins. Richard, you have pushed me both scientifically and personally. You have led by example and I am very grateful to have had the opportunity to spend my graduate career in your laboratory, it is not something I take for granted. Jeff, you helped me gain traction upon entering the lab, gave me direction, and have been an integral part of my journey while at Vanderbilt. You went above and beyond what is expected of any advisor to help mold me into the scientist I am today, and I am grateful to call you a mentor and more importantly, a friend. To my entire committee, Kevin Schey, John McLean, and Lars Plate; I am forever thankful for the time you have taken to help push me towards excellence throughout this journey. I want to thank my lab mates, who are also my closest friends, for their support and friendship throughout this period of my life.
    [Show full text]
  • Molecular Fingerprints the Search for Individualized Medicine
    WINTER03 p.8 The Power of Proteins p.22 One protein’s story p.16 Discovery science p.26 The future of proteomics LensA New Way of Looking at Science Molecular fingerprints The search for individualized medicine. A PUBLICATION OF VANDERBILT UNIVERSITY MEDICAL CENTER Lens – A New Way of Looking at Science WINTER 2003 VOLUME 1, NUMBER 1 Lens is published by Vanderbilt University Medical Center in cooperation with the VUMC Office of News and Public Affairs and the Office of Research. © Vanderbilt University EDITOR Bill Snyder DIRECTOR OF PUBLICATIONS MEDICAL CENTER NEWS AND PUBLIC AFFAIRS Wayne Wood CONTRIBUTING WRITERS Mary Beth Gardiner Leigh MacMillan Bill Snyder PHOTOGRAPHY/ILLUSTRATION Dean Dixon Dominic Doyle The voyage of Dana Johnson Anne Rayner Pollo Brian Smale discovery consists DESIGN Diana Duren/Corporate Design, Nashville not in seeking new COVER ILLUSTRATION Dean Dixon landscapes, but in EDITORIAL OFFICE Office of News and Public Affairs having new eyes. CCC-3312 Medical Center North Vanderbilt University Nashville, Tennessee 37232-2390 615-322-4747 – MARCEL PROUST About the cover: Need help deciphering the fingerprint 'code?' Please turn to the back inside cover. Lens TABLE OF contents WINTER03 2 PUBLICATION OVERVIEW 3 EDITOR’S LETTER 4 MOLECULAR FINGERPRINTS The search for patterns of proteins in blood and tissue one day may help doctors diagnose diseases like cancer earlier and more accurately than ever before. These “molecular fingerprints” also may lead to new, more effective medicines and the ability to tailor treatments to individual patients. The ultimate aim: a more thor- ough understanding of disease and how to prevent it.
    [Show full text]
  • MASS SPECTROMETRY by Michal Kliman Dissertation Submi
    ADVANCED STRUCTURAL AND SPATIAL ANALYSIS OF LIPIDS USING ION MOBILITY – MASS SPECTROMETRY By Michal Kliman Dissertation Submitted to the Faculty of the Graduate School of Vanderbilt University in partial fulfillment of the requirements for the degree of DOCTOR OF PHILOSOPHY in Chemistry August, 2011 Nashville, Tennessee Approved: Professor John A. McLean Professor Terry P. Lybrand Professor H. Alex Brown Professor Christopher J. Janetopoulos Dedicated to Viera, my loving wife, my companion and best friend, our loves Peter, Agatha and Esther, Dad Cyril, Mom Marianna, Sister Mariana, and the Brothers and Sisters in Faith. ii ACKNOWLEDGEMENTS I would like to first thank my advisor, Dr. John A. McLean, for unwavering encouragement, superb advice and for exemplifying and leading in the art of telling a good story. I was fortunate to join Dr. McLean’s laboratory when it first formed, and helped to set up and christen by work the first instruments and optics with and alongside great coworkers Larissa Fenn, Whitney Ridenour, Randi Gant-Branum, Sophie Zhao, Josh Kerr, Sevugarajan Sundarapandian, Ablatt Mahsut, Jeff Enders, Cody Goodwin, Jody May, Jay Forsythe, Seth Byers, Kelly Hines, and Alyssa Granger. I have since witnessed the growth and success of this group, and savored every fruitful conversation and collaboration within and without the laboratory. My academic journey was greatly enriched through training with Eric Dawson, Jarrod Smith, and Jonathan Sheehan, through collaborative work with Niranjana Vijayakrishnan, Dr. Kendal Broadie, Gus Wright, Libin Xu, Keri Tallman, Dr. Ned Porter, Dr. David Hercules, Dr. Zeljka Korade, and Dr. Brian Bachmann. Colleagues from outside of Vanderbilt campus, including Misha Ugarov, Tom Egan, Dr.
    [Show full text]
  • Nature Milestones Mass Spectrometry October 2015
    October 2015 www.nature.com/milestones/mass-spec MILESTONES Mass Spectrometry Produced with support from: Produced by: Nature Methods, Nature, Nature Biotechnology, Nature Chemical Biology and Nature Protocols MILESTONES Mass Spectrometry MILESTONES COLLECTION 4 Timeline 5 Discovering the power of mass-to-charge (1910 ) NATURE METHODS: COMMENTARY 23 Mass spectrometry in high-throughput 6 Development of ionization methods (1929) proteomics: ready for the big time 7 Isotopes and ancient environments (1939) Tommy Nilsson, Matthias Mann, Ruedi Aebersold, John R Yates III, Amos Bairoch & John J M Bergeron 8 When a velocitron meets a reflectron (1946) 8 Spinning ion trajectories (1949) NATURE: REVIEW Fly out of the traps (1953) 9 28 The biological impact of mass-spectrometry- 10 Breaking down problems (1956) based proteomics 10 Amicable separations (1959) Benjamin F. Cravatt, Gabriel M. Simon & John R. Yates III 11 Solving the primary structure of peptides (1959) 12 A technique to carry a torch for (1961) NATURE: REVIEW 12 The pixelation of mass spectrometry (1962) 38 Metabolic phenotyping in clinical and surgical 13 Conquering carbohydrate complexity (1963) environments Jeremy K. Nicholson, Elaine Holmes, 14 Forming fragments (1966) James M. Kinross, Ara W. Darzi, Zoltan Takats & 14 Seeing the full picture of metabolism (1966) John C. Lindon 15 Electrospray makes molecular elephants fly (1968) 16 Signatures of disease (1975) 16 Reduce complexity by choosing your reactions (1978) 17 Enter the matrix (1985) 18 Dynamic protein structures (1991) 19 Protein discovery goes global (1993) 20 In pursuit of PTMs (1995) 21 Putting the pieces together (1999) CITING THE MILESTONES CONTRIBUTING JOURNALS UK/Europe/ROW (excluding Japan): The Nature Milestones: Mass Spectroscopy supplement has been published as Nature Methods, Nature, Nature Biotechnology, Nature Publishing Group, Subscriptions, a joint project between Nature Methods, Nature, Nature Biotechnology, Nature Chemical Biology and Nature Protocols.
    [Show full text]
  • Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging of ZP1609 and Amyloid Beta
    Western University Scholarship@Western Electronic Thesis and Dissertation Repository 9-11-2018 2:00 PM Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging of ZP1609 and Amyloid Beta Jasmine S. H. Wang The University of Western Ontario Supervisor Yeung, Ken K.-C. The University of Western Ontario Co-Supervisor Whitehead, Shawn N. The University of Western Ontario Graduate Program in Chemistry A thesis submitted in partial fulfillment of the equirr ements for the degree in Doctor of Philosophy © Jasmine S. H. Wang 2018 Follow this and additional works at: https://ir.lib.uwo.ca/etd Part of the Analytical Chemistry Commons Recommended Citation Wang, Jasmine S. H., "Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging of ZP1609 and Amyloid Beta" (2018). Electronic Thesis and Dissertation Repository. 5744. https://ir.lib.uwo.ca/etd/5744 This Dissertation/Thesis is brought to you for free and open access by Scholarship@Western. It has been accepted for inclusion in Electronic Thesis and Dissertation Repository by an authorized administrator of Scholarship@Western. For more information, please contact [email protected]. Abstract The revolutionary development of soft ionization techniques like matrix-assisted laser desorption/ionization (MALDI) has opened up the possibilities for mass spectrometry (MS) in protein detection, identification, and sequencing. The ability of MALDI MS to acquire images of intact tissue sections offer an additional dimension of analysis where location information can be attained. Visualization of biological systems help to unravel the complexities of cells, drug pathways, and disease pathology. However, the capabilities of MALDI MS imaging are often being questioned, as signals are typically biased towards the most abundant component within a complex sample.
    [Show full text]
  • 8:00 Pm on Monday. Authors of Odd Numbered Posters Edgewood Chemical Biological Center, Aberdeen Proving (I.E., 001, 003, 005) Present 8:45 – 10:15 Am on Monday
    22S 52nd ASMS Conference on Mass Spectrometry MONDAY POSTERS Centers, INC., Aberdeen Proving Ground, MD; 2Science Monday posters should be set up 7:30 – 8:00 am on Monday and and Technology Corporation, Edgewood, MD; 3U.S. Army, removed 7:30 – 8:00 pm on Monday. Authors of odd numbered posters Edgewood Chemical Biological Center, Aberdeen Proving (i.e., 001, 003, 005) present 8:45 – 10:15 am on Monday. Authors of Ground, MD even numbered posters (i.e., 002, 004, 006) present 1:30 – 3:00 pm on MPA 012 Detection of Pathogenic Bacteria in Mixtures Using Monday. Bacteriophage Amplification Coupled with MALDI- 1 1 1 These special posters will be displayed Monday – Thursday MS; Jon C. Rees ; Leah Doan ; Kent J. Voorhees ; Robert Crawford2; 1Colorado School of Mines, Golden, CO; Updating the List of Terms and Definitions for Mass 2 Spectrometry; Damien A. Narcisse; Kermit K. Murray; Armed Forces Institute of Pathology, Washington, D.C. Louisiana State University, Baton Rouge, LA MPA 013 Exploring AP/MALDI/MS and AP/MALDI/FAIMS/MS XML Standard for Analytical Information as Novel Instrumental Approaches for Biological Agent 17TH International Mass Spectrometry Conference Analysis; Alisha C Mitchell-Roberts; Richard A Yost; University of Florida, Gainesville, FL ANTITERRORISM MS: BACTERIAL MPA 014 Novel Online MALDI Techniques for Improved Signal MPA 002 Atmospheric Pressure MALDI Facilitates Proteomics- of Biomarkers in an Aerosol Mass Spectrometer; Gregg Based Analysis of Bacillus Spore Mixtures; Patrick A. 1 1 2 1 2 1 A Czerwieniec ; Scott C
    [Show full text]
  • Multimodal FTIR Microscopy-Guided Acquisition and Interpretation of MALDI Mass Spectrometry Imaging Data
    Aus dem Institut für Medizintechnologie der Universität Heidelberg und der Hochschule Mannheim (Geschäftsführender Direktor: Prof. Dr. med. Norbert Gretz) Multimodal FTIR Microscopy-guided Acquisition and Interpretation of MALDI Mass Spectrometry Imaging Data Inauguraldissertation zur Erlangung des akademischen Grades Doctor scientiarum humanarum (Dr. sc. hum.) der Medizinischen Fakultät Mannheim der Ruprecht-Karls-Universität zu Heidelberg vorgelegt von Jan-Hinrich Rabe aus Holzminden 2017 Dekan: Prof. Dr. med. Sergij Goerdt Referent: Prof. Dr. rer. nat. Carsten Hopf Abbreviations ABBREVIATIONS ABA Allen Mouse Brain Reference Atlas ACN Acetonitrile AUC Area Under the Curve CCD Charge-Coupled Device CMC Carboxymethyl Cellulose CPU Central Processing Unit CT Computed Tomography DESI Desorption Electrospray Ionization ddH2O Ultra-Pure Water DMSO Dimethyl sulfoxide DSC Dice Similarity Coefficient EPD Edge-Preserving Denoising ESI Electrospray Ionization EtOH Ethanol FTICR Fourier Transform Ion Cyclotron Resonance FTIR Fourier Transform Infrared Spectroscopy GIST Gastrointestinal Stromal Tumors H&E Hematoxylin & Eosin ITO Indium Tin Oxide LCMD Laser Capture Microdissection LC-MS/MS Liquid Chromatography – Tandem Mass Spectrometry m/z Mass-to-Charge Ratio MALDI-TOF-MS Matrix Assisted Laser Desorption/ Ionization-Time of Flight Mass Spectrometry MeOH Methanol MIR Mid-Infrared MRI Magnetic Resonance Imaging MS Mass Spectrometry MSI Mass Spectrometry Imaging Nd:YAG Neodymium-Doped Yttrium Aluminium Garnet NIR Near-Infrared PCA Principal Component Analysis PET Positron Emission Tomography PhCCAA Phenyl-α-Cyanocinnamic Acid Amide REIMS Rapid Evaporation Ionization Mass Spectrometry ROI Region of Interest RT Room temperature S/N Signal-to-Noise Ratio SNV Standard Normal Variate SPECT Single-Photon Emission Computed Tomography TFA Trifluoroacetic acid TIC Total Ion Current t-SNE t-Distributed Stochastic Neighbor Embedding U.S.
    [Show full text]
  • June 15 - 19, 2014 • Baltimore, Maryland
    62ND ASMS CONFERENCE ON MASS SPECTROMETRY AND ALLIED TOPICS June 15 - 19, 2014 • Baltimore, maryland Welcome to the 62nd ASMS Conference on Mass Spectrometry and Allied Topics. Conference program activities and exhibit booths are in the Baltimore Convention Center. Corporate Member hospitality suites are located in the Hilton Hotel. SPONSORS ASMS gratefully acknowledges the support TABLE OF CONTENTS of these companies. GENERAL INFORMATION ....................................... 2 HOTELS AND TRANSPORTATION ........................... 5 ASMS BOARD OF DIRECTORS ............................ 6 INTEREST GROUPS AND COMMITTEES .................. 7 AWARDS.............................................................. 8 Mobile App and WiFi CONVENTION CENTER FLOOR PLANS ................ 10 POSTER / EXHIBIT HALL FLOOR PLAN ...............11 CORPORATE HOSPITALITY SUITES ..................... 12 Closing Event ASMS CORPORATE MEMBERS ......................... 13 PROGRAM ACKNOWLEDGEMENTS ....................... 17 CONFERENCE SPONSORS PROGRAM OVERVIEW ........................................ 18 WORKSHOPS ..................................................... 23 Titles in the following sections are provided by authors. The complete abstracts are available online: www.asms.org The PDF document of proceedings submissions for orals and posters may be viewed online one day after presentation at the conference. SUNDAY ............................................................ 28 MONDAY ORAL SESSIONS ................................. 28 TUESDAY ORAL SESSIONS
    [Show full text]
  • CHEMICAL HERITAGE FOUNDATION FRANZ HILLENKAMP Transcript Of
    CHEMICAL HERITAGE FOUNDATION FRANZ HILLENKAMP Transcript of Interviews Conducted by Michael A. Grayson at University of Münster Münster, Germany on 20 August 2012 (With Subsequent Corrections and Additions) ACKNOWLEDGMENT This oral history is one in a series initiated by the Chemical Heritage Foundation on behalf of the American Society for Mass Spectrometry. The series documents the personal perspectives of individuals related to the advancement of mass spectrometric instrumentation, and records the human dimensions of the growth of mass spectrometry in academic, industrial, and governmental laboratories during the twentieth century. This project is made possible through the generous support of the American Society for Mass Spectrometry. CHEMICAL HERITAGE FOUNDATION Center for Oral History FINAL RELEASE FORM This document contains my understanding and agreement with the Chemical Heritage Foundation and the American Society for Mass Spectrometry with respect to my participation in the audio- and/or video- recorded interview conducted by Michael Grayson on 20 August 2012. I have read the transcript supplied by the Chemical Heritage Foundation. 1. The recordings, transcripts, photographs, research materials, and memorabilia (collectively called the “Work”) will be maintained by the Chemical Heritage Foundation and the American Society for Mass Spectrometry and made available in accordance with general policies for research and other scholarly purposes. 2. I hereby grant, assign, and transfer to the Chemical Heritage Foundation and the American Society for Mass Spectrometry all right, title, and interest in the Work, including the literary rights and the copyright, except that I shall retain the right to copy, use, and publish the Work in part or in full until my death.
    [Show full text]
  • IMSC2018-PROGRAM.Pdf
    XXII International Mass Spectrometry Conference AUGUST 26-31, 2018 FLORENCE, ITALY www.imsc2018.it th SATURDAY, AUGUST 25th TUESDAY, AUGUST 28th THURSDAY, AUGUST 30 SHORT COURSE 1 SHORT COURSE 2 SHORT COURSE 3 SHORT COURSE 4 SHORT COURSE 5 Thomson Medal Award ceremony PLENARY LECTURE 5 - THOMSON MEDALIST PLENARY LECTURE 3 - THOMSON MEDALIST 8:30 John R. Yates, The Scripps Research Institute, La Jolla (USA) SPME: Comprehen- 8:30 Expanded Newborn Albert J. R. Heck, Netherlands Proteomics Centre, Utrecht University (The Netherlands) a.m. sive Overview of a.m. Driving Innovation - From a Protein Sequence to a Proteome Fundamentals of Foodomics & Mass Mass Spectrometry Screening by the Technology & Gaining weight in mass spectrometry. From analyzing electrons to intact molecular machineries 9:15 Mass Spectrometry Spectrometry Imaging Tandem Mass BREAK Applications to 9:15 a.m. 2:00 Spectrometry BREAK Analytical MS a.m. ThO1 - Glycomics, ThO2 - Probing ThO3 - Natural p.m. ThO4 - ThO5 - Safe & TU: Marialaura TO1 - Therapeutic TO4 - HRMS: Saccharides & Protein Structure & Substances & Their TU: Michele Suman, Dilillo, Manuel Galli, TU: Giancarlo la TU: Janusz TO3 - Noncovalent TO5 - MS Imaging: 9:30 Environmental MS Valuable Food 9:30 drug monitoring & TO2 - Single Cell Instrum., Methods Glycoconjugates Dynamics Complexes TU: Jürgen H. Gross, Laurent Debrauwer, Liam McDonnell, Marca, Marzia Pawliszyn, Barbara Interactions Instrumentation a.m. drug discovery & Applications KN: Isabelle KN: Thomas J. D. KN: Pierre-Marie KN: Susan KN: Laurent David Sparkman Fulvio Mattivi, Laura Andrew Smith, Pasquali, Hugo Bojko, Nikita Looby, a.m. Compagnon Jørgensen Allard Richardson Debrauwer Righetti Martina Marchetti- Rocha Tijana Vasiljevic KN: Rob Vreeken KN: Zhibo Yang KN: Carol Robinson KN: Alan Marshall KN: Ron Heeren COFFEE BREAK / POSTER SESSIONS Deschmann COFFEE BREAK / POSTER SESSIONS 11:30 11:30 ThPS-S01 - ThPS-S13 4:30 TPS-S01 - TPS-S10 a.m.
    [Show full text]
  • EAS Final 2014.Indd
    O O OH HO O NHMe HO O HO H N O N H Cl O H N HO O N H O O N O H NH2 2H CO 2014 Eastern Analytical Symposium & Exposition HN TheOH Art and Science of Analysis OH HO Final Program November 17–19, 2014 Garden State Exhibit Center Somerset, New Jersey EAS.org 000820-EAS_8.5x11_2014Cover-FinalProgram_PREP.indd 1 8/1/14 10:46 AM Owlstone Lonestar Owlstone ultraFAIMS Real-time VOC detection A new dimension in …within liquid, solid, & gas streams Mass Spectrometry Owlstone’s portable Lonestar analyzer can …add ion mobility to your be programmed to Agilent G6460 LCMS handle multiple VOC detection applica- tions and has been specifically designed so that non-technical Owlstone UltraFAIMS Agilent G6460CA LCMS personnel can obtain real-time quantitative results at the push of a button right at the source. ultraFAIMS Applications: Lonestar VOC Applications: • Improve mass accuracy • Residual Solvent Monitoring • Improve level of quantitation & dynamic range • Flavor Analysis • Improve detection limits for low abundance • Raw Material Contaminant Monitoring analytes in noisy backgrounds • In Process Reaction Monitoring • Provide additional separation within LC peaks • Mal Odor Analysis • Provide pre-selection prior to in-source CID • Cleaning Residues Detection • Separate structural isomers and conformers • Product Freshness • Separate charge states of proteins & peptides • Separate larger proteins from smaller proteins • Waste Water Analysis & peptides to support top-down proteomics • Oxidation Markers/Product Freshness • Provide rapid pre-separation to support direct • Product Packaging VOCs ionization methods Field Asymmetric Ion Mobility Spectrometry (UltraFAIMS) is a high speed, gas phase ion separation technique.
    [Show full text]