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I HIGH MASS ACCURACY COUPLED to SPATIALLY-DIRECTED
HIGH MASS ACCURACY COUPLED TO SPATIALLY-DIRECTED PROTEOMICS FOR IMPROVED PROTEIN IDENTIFICATIONS IN IMAGING MASS SPECTROMETRY EXPERIMENTS By David Geoffrey Rizzo Dissertation Submitted to the Faculty of the Graduate School of Vanderbilt University in partial fulfillment of the requirements for the degree of DOCTOR OF PHILOSOPHY in Chemistry August, 2016 Nashville, Tennessee Approved: Richard M. Caprioli, Ph.D. Kevin L. Schey, Ph.D. John A. McLean, Ph.D. Michael P. Stone, Ph.D. i Copyright © 2016 by David Geoffrey Rizzo All Rights Reserved ii This work is dedicated to my family and friends, who have shown nothing but support for me in all of life’s endeavors. iii ACKNOWLEDGEMENTS “As we express our gratitude, we must never forget that the highest appreciation is not to utter words, but to live by them.” - John F. Kennedy – There are many people I must thank for showing kindness, encouragement, and support for me during my tenure as a graduate student. First and foremost, I would like to thank my research advisor, Richard Caprioli, for providing both ample resources and guidance that allowed me to grow as a scientist. Our discussions about my research and science in general have helped me become a much more focused and discerning analytical chemist. I must also thank my Ph.D. committee members, Drs. Kevin Schey, John McLean, and Michael Stone, who have brought valuable insight into my research and provided direction along the way. My undergraduate advisor, Dr. Facundo Fernández, encouraged me to begin research in his lab and introduced me to the world of mass spectrometry. -
Volcanic History of the Imbrium Basin: a Close-Up View from the Lunar Rover Yutu
Volcanic history of the Imbrium basin: A close-up view from the lunar rover Yutu Jinhai Zhanga, Wei Yanga, Sen Hua, Yangting Lina,1, Guangyou Fangb, Chunlai Lic, Wenxi Pengd, Sanyuan Zhue, Zhiping Hef, Bin Zhoub, Hongyu Ling, Jianfeng Yangh, Enhai Liui, Yuchen Xua, Jianyu Wangf, Zhenxing Yaoa, Yongliao Zouc, Jun Yanc, and Ziyuan Ouyangj aKey Laboratory of Earth and Planetary Physics, Institute of Geology and Geophysics, Chinese Academy of Sciences, Beijing 100029, China; bInstitute of Electronics, Chinese Academy of Sciences, Beijing 100190, China; cNational Astronomical Observatories, Chinese Academy of Sciences, Beijing 100012, China; dInstitute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China; eKey Laboratory of Mineralogy and Metallogeny, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou 510640, China; fKey Laboratory of Space Active Opto-Electronics Technology, Shanghai Institute of Technical Physics, Chinese Academy of Sciences, Shanghai 200083, China; gThe Fifth Laboratory, Beijing Institute of Space Mechanics & Electricity, Beijing 100076, China; hXi’an Institute of Optics and Precision Mechanics, Chinese Academy of Sciences, Xi’an 710119, China; iInstitute of Optics and Electronics, Chinese Academy of Sciences, Chengdu 610209, China; and jInstitute of Geochemistry, Chinese Academy of Science, Guiyang 550002, China Edited by Mark H. Thiemens, University of California, San Diego, La Jolla, CA, and approved March 24, 2015 (received for review February 13, 2015) We report the surface exploration by the lunar rover Yutu that flows in Mare Imbrium was obtained only by remote sensing from landed on the young lava flow in the northeastern part of the orbit. On December 14, 2013, Chang’e-3 successfully landed on the Mare Imbrium, which is the largest basin on the nearside of the young and high-Ti lava flow in the northeastern Mare Imbrium, Moon and is filled with several basalt units estimated to date from about 10 km south from the old low-Ti basalt unit (Fig. -
Of Vertebrate Fossils from the Middle Eocene Oil Shale of Messel, Germany: Implications for Their Taphonomy and Palaeoenvironment
Palaeogeography, Palaeoclimatology, Palaeoecology 416 (2014) 92–109 Contents lists available at ScienceDirect Palaeogeography, Palaeoclimatology, Palaeoecology journal homepage: www.elsevier.com/locate/palaeo Isotope compositions (C, O, Sr, Nd) of vertebrate fossils from the Middle Eocene oil shale of Messel, Germany: Implications for their taphonomy and palaeoenvironment Thomas Tütken ⁎ Steinmann-Institut für Geologie, Mineralogie und Paläontologie, Universität Bonn, Poppelsdorfer Schloss, 53115 Bonn, Germany article info abstract Article history: The Middle Eocene oil shale deposits of Messel are famous for their exceptionally well-preserved, articulated 47- Received 15 April 2014 Myr-old vertebrate fossils that often still display soft tissue preservation. The isotopic compositions (O, C, Sr, Nd) Received in revised form 30 July 2014 were analysed from skeletal remains of Messel's terrestrial and aquatic vertebrates to determine the condition of Accepted 5 August 2014 geochemical preservation. Authigenic phosphate minerals and siderite were also analysed to characterise the iso- Available online 17 August 2014 tope compositions of diagenetic phases. In Messel, diagenetic end member values of the volcanically-influenced 12 Keywords: and (due to methanogenesis) C-depleted anoxic bottom water of the meromictic Eocene maar lake are isoto- Strontium isotopes pically very distinct from in vivo bioapatite values of terrestrial vertebrates. This unique taphonomic setting al- Oxygen isotopes lows the assessment of the geochemical preservation of the vertebrate fossils. A combined multi-isotope Diagenesis approach demonstrates that enamel of fossil vertebrates from Messel is geochemically exceptionally well- Enamel preserved and still contains near-in vivo C, O, Sr and possibly even Nd isotope compositions while bone and den- Messel tine are diagenetically altered. -
Alaska Regional Directors Offices Director Email Address Contact Numbers Supt
Alaska Regional Directors Offices Director Email Address Contact Numbers Supt. Phone Fax Code ABLI RegionType Unit U.S Fish and Wildlife Service (FWS) Alaska Region (FWS) HASKETT,GEOFFREY [email protected] 1011 East Tudor Road Phone: 907‐ 786‐3309 Anchorage, AK 99503 Fax: 907‐ 786‐3495 Naitonal Park Service(NPS) Alaska Region (NPS) MASICA,SUE [email protected] 240 West 5th Avenue,Suite 114 Phone:907‐644‐3510 Anchoorage,AK 99501 Bureau of Indian Affairs(BIA) Alaska Region (BIA) VIRDEN,EUGENE [email protected] Bureau of Indian Affairs Phone: 907‐586‐7177 PO Box 25520 Telefax: 907‐586‐7252 709 West 9th Street Juneau, AK 99802 Anchorage Agency Phone: 1‐800‐645‐8465 Bureau of Indian Affairs Telefax:907 271‐4477 3601 C Street Suite 1100 Anchorage, AK 99503‐5947 Telephone: 1‐800‐645‐8465 Bureau of Land Manangement (BLM) Alaska State Office (BLM) CRIBLEY,BUD [email protected] Alaska State Office Phone: 907‐271‐5960 222 W 7th Avenue #13 FAX: 907‐271‐3684 Anchorage, AK 99513 United States Geological Survey(USGS) Alaska Area (USGS) BARTELS,LESLIE lholland‐[email protected] 4210 University Dr., Anchorage, AK 99508‐4626 Phone:907‐786‐7055 Fax: 907‐ 786‐7040 Bureau of Ocean Energy Management(BOEM) Alaska Region (BOEM) KENDALL,JAMES [email protected] 3801 Centerpoint Drive Phone: 907‐ 334‐5208 Suite 500 Anchorage, AK 99503 Ralph Moore [email protected] c/o Katmai NP&P (907) 246‐2116 ANIA ANTI AKR NPRES ANIAKCHAK P.O. Box 7 King Salmon, AK 99613 (907) 246‐3305 (907) 246‐2120 Jeanette Pomrenke [email protected] P.O. -
Issue 189.Pmd
email: [email protected] NIGHTSHIFTwebsite: nightshift.oxfordmusic.net Free every Oxford’s Music Magazine month. Issue 189 April 2011 YYYYYYoungoungoungoung KnivesKnivesKnivesKnives Go Pop! Out on their own and back with a brilliant new album photo: Cat Stevens NIGHTSHIFT: PO Box 312, Kidlington, OX5 1ZU. Phone: 01865 372255 NEWNEWSS Nightshift: PO Box 312, Kidlington, OX5 1ZU Phone: 01865 372255 email: [email protected] Online: nightshift.oxfordmusic.net WILCO JOHNSON AND listings for the weekend, plus ticket DEACON BLUE are the latest details, are online at names added to this year’s www.oxfordjazzfestival.co.uk Cornbury Festival bill. The pair join already-announced headliners WITNEY MUSIC FESTIVAL returns James Blunt, The Faces and for its fifth annual run this month. Status Quo on a big-name bill that The festival runs from 24th April also includes Ray Davies, Cyndi through to 2nd May, featuring a Lauper, Bellowhead, Olly Murs, selection of mostly local acts across a GRUFF RHYS AND BELLOWHEAD have been announced as headliners The Like and Sophie Ellis-Bextor. dozen venues in the town. Amongst a at this year’s TRUCK FESTIVAL. Other new names on the bill are host of acts confirmed are Johnson For the first time Truck will run over three full days, over the weekend of prog-folksters Stackridge, Ben Smith and the Cadillac Blues Jam, 22nd-24th July at Hill Farm in Steventon. The festival will also enjoy an Montague & Pete Lawrie, Toy Phousa, Alice Messenger, Black Hats, increased capacity and the entire site has been redesigned to accommodate Hearts, Saint Jude and Jack Deer Chicago, Prohibition Smokers new stages. -
Rules and Options
Rules and Options The author has attempted to draw as much as possible from the guidelines provided in the 5th edition Players Handbooks and Dungeon Master's Guide. Statistics for weapons listed in the Dungeon Master's Guide were used to develop the damage scales used in this book. Interestingly, these scales correspond fairly well with the values listed in the d20 Modern books. Game masters should feel free to modify any of the statistics or optional rules in this book as necessary. It is important to remember that Dungeons and Dragons abstracts combat to a degree, and does so more than many other game systems, in the name of playability. For this reason, the subtle differences that exist between many firearms will often drop below what might be called a "horizon of granularity." In D&D, for example, two pistols that real world shooters could spend hours discussing, debating how a few extra ounces of weight or different barrel lengths might affect accuracy, or how different kinds of ammunition (soft-nosed, armor-piercing, etc.) might affect damage, may be, in game terms, almost identical. This is neither good nor bad; it is just the way Dungeons and Dragons handles such things. Who can use firearms? Firearms are assumed to be martial ranged weapons. Characters from worlds where firearms are common and who can use martial ranged weapons will be proficient in them. Anyone else will have to train to gain proficiency— the specifics are left to individual game masters. Optionally, the game master may also allow characters with individual weapon proficiencies to trade one proficiency for an equivalent one at the time of character creation (e.g., monks can trade shortswords for one specific martial melee weapon like a war scythe, rogues can trade hand crossbows for one kind of firearm like a Glock 17 pistol, etc.). -
Obituary 1967
OBITUARY INDEX 1967 You can search by clicking on the binoculars on the adobe toolbar or by Pressing Shift-Control-F Request Form LAST NAME FIRST NAME DATE PAGE # Abbate Barbara F. 6/6/1967 p.1 Abbott William W. 9/22/1967 p.30 Abel Dean 11/27/1967 p.24 Abel Francis E. 9/25/1967 p.24 Abel Francis E. 9/27/1967 p.10 Abel Frederick B. 11/11/1967 p.26 Abel John Hawk 12/7/1967 p.42 Abel John Hawk 12/11/1967 p.26 Abel William E. 7/10/1967 p.28 Abel William E. 7/12/1967 p.12 Aber George W. 3/14/1967 p.24 Abert Esther F. 7/26/1967 p.14 Abrams Laura R. Hoffman 8/14/1967 p.28 Abrams Laura R. Hoffman 8/17/1967 p.28 Abrams Pearl E. 10/19/1967 p.28 Abrams Pearl E. 10/20/1967 p.10 Achenbach Helen S. 11/6/1967 p.36 Achenbach Helen S. 11/8/1967 p.15 Ackerman Calvin 5/22/1967 p.34 Ackerman Calvin 5/25/1967 p.38 Ackerman Fritz 11/27/1967 p.24 Ackerman Harold 10/27/1967 p.26 Ackerman Harold 10/28/1967 p.26 Ackerman Hattie Mann 4/14/1967 p.21 Ackerman Hattie Mann 4/19/1967 p.14 Adamczyk Bennie 5/3/1967 p.14 Adamo Margaret M. 3/15/1967 p.15 Adamo Margaret M. 3/20/1967 p.28 Adams Anna 6/17/1967 p.22 Adams Anna 6/20/1967 p.17 Adams Harriet C. -
Visualization of Chemical Space Using Principal Component Analysis
World Applied Sciences Journal 29 (Data Mining and Soft Computing Techniques): 53-59, 2014 ISSN 1818-4952 © IDOSI Publications, 2014 DOI: 10.5829/idosi.wasj.2014.29.dmsct.10 Visualization of Chemical Space Using Principal Component Analysis B. Firdaus Begam and J. Satheesh Kumar Department of Computer Applications, School of Computer Science and Engineering, Bharathiar University, Coimbatore, Tamilnadu, India Abstract: Principal component analysis is one of the most widely used multivariate methods to visualize chemical space in new dimension by the chemist for analysing data. In Multivariate data analysis, the relationship between two variables with more number of characteristics can be considered. PCA provides a compact view of variation in chemical data matrix which helps in creating better Quantitative Structure Activity Relationship (QSAR) model. It highlights the dominating pattern in the matrix through principal component and graphical representation. This paper focuses on mathematical aspects of principal components and role of PCA on Maybridge dataset to identify dominating hidden patterns of drug likeness based on Lipinski RO5. Key words: Principal Component Analysis Load p lot Score plot Biplot INTRODUCTION a new model of selected objects and variables with minimal loss of information. It can also be used for Principal Component Analysis (PCA) is a multivariate prediction model as PCA acts as exploratory tool for data statistical approach to analyze data in lower dimensional analysis by calculating the variance among the variables space. PCA used vector space transformation technique which are uncorrelated [8]. to view datasets from higher-dimensional space to lower Chemical space (drug space) is defined as dimensional space. PCA is an application of linear algebra number of descriptors calculated for each molecule [2] which was first coined by Karl Pearson during 1901 [1]. -
Developing Next Generation Technologies for Spatially Targeted
Developing Next Generation Technologies for Spatially Targeted Proteomics By Daniel Joseph Ryan Dissertation Submitted to the Faculty of the Graduate School of Vanderbilt University in partial fulfillment of the requirements for the degree of DOCTOR OF PHILOSOPHY in Chemistry June 30th, 2019 Nashville, Tennessee Approved: Richard M. Caprioli, Ph.D. Jeffrey M. Spraggins, Ph.D. John A. McLean, Ph.D. Lars Plate, Ph.D. Kevin L. Schey, Ph.D. Copyright © 2019 by Daniel Joseph Ryan All Rights Reserved ii ACKNOWLEDGEMENTS It is with the help of many people that I am afforded the unique privilege of being able to sit here and write out an acknowledgements section for my dissertation. First and foremost, I would like to thank both of advisors, Dr. Richard Caprioli and Dr. Jeff Spraggins. Richard, you have pushed me both scientifically and personally. You have led by example and I am very grateful to have had the opportunity to spend my graduate career in your laboratory, it is not something I take for granted. Jeff, you helped me gain traction upon entering the lab, gave me direction, and have been an integral part of my journey while at Vanderbilt. You went above and beyond what is expected of any advisor to help mold me into the scientist I am today, and I am grateful to call you a mentor and more importantly, a friend. To my entire committee, Kevin Schey, John McLean, and Lars Plate; I am forever thankful for the time you have taken to help push me towards excellence throughout this journey. I want to thank my lab mates, who are also my closest friends, for their support and friendship throughout this period of my life. -
Actual Problems Актуальные Проблемы
АКАДЕМИЯ НАУК АВИАЦИИ И ВОЗДУХОПЛАВАНИЯ РОССИЙСКАЯ АКАДЕМИЯ КОСМОНАВТИКИ ИМ. К.Э.ЦИОЛКОВСКОГО ACADEMY OF AVIATION AND AERONAUTICS SCIENCES RUSSIAN ASTRONAUTICS ACADEMY OF K.E.TSIOLKOVSKY'S NAME СССР 7 195 ISSN 1727-6853 12.04.1961 АКТУАЛЬНЫЕ ПРОБЛЕМЫ АВИАЦИОННЫХ И АЭРОКОСМИЧЕСКИХ СИСТЕМ процессы, модели, эксперимент 2(39) 2014 RUSSIAN-AMERICAN SCIENTIFIC JOURNAL ACTUAL PROBLEMS OF AVIATION AND AEROSPACE SYSTEMS processes, models, experiment УРНАЛ УЧНЫЙ Ж О-АМЕРИКАНСКИЙ НА ОССИЙСК Р Казань Daytona Beach А К Т УА Л Ь Н Ы Е П Р О Б Л Е М Ы А В И А Ц И О Н Н Ы Х И А Э Р О К О С М И Ч Е С К И Х С И С Т Е М Казань, Дайтона Бич Вып. 2 (39), том 19, 1-206, 2014 СОДЕРЖАНИЕ CONTENTS Г.В.Новожилов 1 G.V.Novozhilov К 120-летию авиаконструктора To the 120-th Anniversary of Сергея Владимировича Ильюшина Sergey Vladimirovich Ilyushin А.Болонкин 14 A.Bolonkin Использование энергии ветра Utilization of wind energy at high больших высот altitude Эмилио Спедикато 46 Emilio Spedicato О моделировании взаимодействия About modelling interaction of Earth Земли с крупным космическим with large space object: the script with объектом: сценарий взрыва Фаэтона explosion of Phaeton and the sub- и последующей эволюции sequent evolution of Mankind (part II) Человечества (часть II) М.В.Левский 76 M.V.Levskii Оптимальное по времени The time-optimal control of motion of a управление движением spacecraft with inertial executive космического аппарата с devices инерционными исполнительными органами В.А.Афанасьев, А.С.Мещанов, 99 V.A.Afanasyev, A.S.Meshchanov, Е.Ю.Самышева -
Application of Tetraether Membrane Lipids As Proxies for Continental Climate
Institut de Ciència i Tecnologia Ambientals Universitat Autònoma de Barcelona Application of tetraether membrane lipids as proxies for continental climate reconstruction in Iberian and Siberian lakes Marina Escala Pascual Tesi doctoral Institut de Ciència i Tecnologia Ambientals Universitat Autònoma de Barcelona Application of tetraether membrane lipids as proxies for continental climate reconstruction in Iberian and Siberian lakes Memòria presentada per Marina Escala Pascual per optar al títol de Doctor per la Universitat Autònoma de Barcelona, sota la direcció del doctor Antoni Rosell Melé. Marina Escala Pascual Abril 2009 Cover photograph: Lake Baikal (Jens Klump, Continent Project) Als meus pares i al meu germà. INDEX Acknowledgements .................................................................................i Abstract .................................................................................................iii Resum ....................................................................................................iv Chapter 1 Introduction 1.1. Paleoclimate and biomarker proxies ....................................................3 1.2. Distribution of Archaea in freshwater environments ........................5 1.3. Origin and significance of GDGTs .......................................................9 1.4. Calibration of GDGT-based proxies ..................................................14 1.5. Objective and outline of this thesis ....................................................19 Chapter 2 Methodology 2.1. -
Exploring Chemical Space
Frontier of Chemistry Exploring Chemical Space Shuli Mao 04/12/2008 Shuli Mao @ Wipf Group Page 1 of 40 4/15/2008 What is chemical space? Chemical space is the space spanned by all possible (i.e. energetically stable) stoichiometrical combinations of electrons and atomic nuclei and topologies (isomers) in molecules and compounds in general. -----wilkipedia Chemical space is defined as the total descriptor space that encompasses all the small carbon-based molecules that could in principle be created. (Descriptors: molecular mass, liphophilicity and topological features, etc.) -----Dobson, C. M. Chemical space and biology Nature 2004, 432, 824. Shuli Mao @ Wipf Group Page 2 of 40 4/15/2008 Why we need to explore chemical space? The estimated number of small carbon-based compounds is on the order of 1060. However, only a minute fraction of this chemical space has been explored. Given the vastness of chemical space, we need to explore chemical space efficiently to find biologically relevant chemical space (space in which biologically active compounds reside). Dobson, C. M. Chemical space and biology Nature 2004, 432, 824. • To understand biological systems especially in unknown area • To develop potential drugs From 1994 to 2001, only 22 drugs that modulate new targets were approved. So far, less than 500 human proteins have been targeted by current drugs, which is a small portion of human proteins. Lipinski, C; Hopkins, A. Navigating chemical space for biology and medicine Nature 2004, 432, 855. Shuli Mao @ Wipf Group Page 3 of 40 4/15/2008 How to explore chemical space? Three approaches: (A) Target-Oriented Synthesis (B) Focused Synthesis (Medicinal Chemistry/ Combinatorial Chemistry) (C) Diversity-Oriented Synthesis Burke, M.