The Vestibulo-Cochlear Nerve (Cranial Nerve 8) (Vestibular & Auditory Pathways)
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Pathophysiological Mechanisms and Functional Hearing Consequences of Auditory Neuropathy
doi:10.1093/brain/awv270 BRAIN 2015: 138; 3141–3158 | 3141 REVIEW ARTICLE Pathophysiological mechanisms and functional hearing consequences of auditory neuropathy Gary Rance1 and Arnold Starr2 The effects of inner ear abnormality on audibility have been explored since the early 20th century when sound detection measures were first used to define and quantify ‘hearing loss’. The development in the 1970s of objective measures of cochlear hair cell Downloaded from function (cochlear microphonics, otoacoustic emissions, summating potentials) and auditory nerve/brainstem activity (auditory brainstem responses) have made it possible to distinguish both synaptic and auditory nerve disorders from sensory receptor loss. This distinction is critically important when considering aetiology and management. In this review we address the clinical and pathophysiological features of auditory neuropathy that distinguish site(s) of dysfunction. We describe the diagnostic criteria for: (i) presynaptic disorders affecting inner hair cells and ribbon synapses; (ii) postsynaptic disorders affecting unmyelinated auditory http://brain.oxfordjournals.org/ nerve dendrites; (iii) postsynaptic disorders affecting auditory ganglion cells and their myelinated axons and dendrites; and (iv) central neural pathway disorders affecting the auditory brainstem. We review data and principles to identify treatment options for affected patients and explore their benefits as a function of site of lesion. 1 Department of Audiology and Speech Pathology, The University of Melbourne, -
Common Vestibular Function Tests
Common Vestibular Function Tests Authors: Barbara Susan Robinson, PT, DPT; Lisa Heusel-Gillig PT DPT NCS Fact Sheet The purpose of Vestibular Function Tests (VFTs) is to determine the health of the vestibular portion of the inner ear. These tests are commonly performed by ENTs, Audiologists, and Otolaryngologists Electronystagmography or Videonystagmography Electronystagmography (ENG test) or Videonystagmography (VNG test) evaluate the inner ear. Both record eye movements during a group of tests in light and dark rooms. During the ENG test, small electrodes are placed on the skin near the eyes to record eye movements. For the VNG test, eye movements are recorded by a video camera mounted inside of goggles that are worn during testing. ENG and VNG tests evaluate eye movements while following a visual target (tracking Produced by test) or during body and head position changes (positional test). The caloric test evaluates eye movements in response to cool or warm air (or water) placed in the ear canal. If there is no response to warm or cool air or water, ice water may be used in order to try to produce a response. The caloric test determines the difference between the function of the left and right inner ear. During this test, you may experience dizziness or nausea. You may be asked questions (math questions, city names, alphabet tasks) to distract you in order to get the best results. A Special Interest Group of Contact us: ANPT Other Common Vestibular Function Tests 5841 Cedar Lake Rd S. The rotary chair test is used along with the VNG to confirm the diagnosis and assess Ste 204 compensation of the vestibular system. -
Vestibular Neuritis, Labyrinthitis, and a Few Comments Regarding Sudden Sensorineural Hearing Loss Marcello Cherchi
Vestibular neuritis, labyrinthitis, and a few comments regarding sudden sensorineural hearing loss Marcello Cherchi §1: What are these diseases, how are they related, and what is their cause? §1.1: What is vestibular neuritis? Vestibular neuritis, also called vestibular neuronitis, was originally described by Margaret Ruth Dix and Charles Skinner Hallpike in 1952 (Dix and Hallpike 1952). It is currently suspected to be an inflammatory-mediated insult (damage) to the balance-related nerve (vestibular nerve) between the ear and the brain that manifests with abrupt-onset, severe dizziness that lasts days to weeks, and occasionally recurs. Although vestibular neuritis is usually regarded as a process affecting the vestibular nerve itself, damage restricted to the vestibule (balance components of the inner ear) would manifest clinically in a similar way, and might be termed “vestibulitis,” although that term is seldom applied (Izraeli, Rachmel et al. 1989). Thus, distinguishing between “vestibular neuritis” (inflammation of the vestibular nerve) and “vestibulitis” (inflammation of the balance-related components of the inner ear) would be difficult. §1.2: What is labyrinthitis? Labyrinthitis is currently suspected to be due to an inflammatory-mediated insult (damage) to both the “hearing component” (the cochlea) and the “balance component” (the semicircular canals and otolith organs) of the inner ear (labyrinth) itself. Labyrinthitis is sometimes also termed “vertigo with sudden hearing loss” (Pogson, Taylor et al. 2016, Kim, Choi et al. 2018) – and we will discuss sudden hearing loss further in a moment. Labyrinthitis usually manifests with severe dizziness (similar to vestibular neuritis) accompanied by ear symptoms on one side (typically hearing loss and tinnitus). -
Diseases of the Brainstem and Cranial Nerves of the Horse: Relevant Examination Techniques and Illustrative Video Segments
IN-DEPTH: NEUROLOGY Diseases of the Brainstem and Cranial Nerves of the Horse: Relevant Examination Techniques and Illustrative Video Segments Robert J. MacKay, BVSc (Dist), PhD, Diplomate ACVIM Author’s address: Alec P. and Louise H. Courtelis Equine Teaching Hospital, College of Veterinary Medicine, University of Florida, Gainesville, FL 32610; e-mail: mackayr@ufl.edu. © 2011 AAEP. 1. Introduction (pons and cerebellum) and myelencephalon (me- This lecture focuses on the functions of the portions dulla oblongata). Because the diencephalon was of the brainstem caudal to the diencephalon. In discussed in the previous lecture under Forebrain addition to regulation of many of the homeostatic Diseases, it will not be covered here. mechanisms of the body, this part of the brainstem controls consciousness, pupillary diameter, eye 3. Functions (Location) movement, facial expression, balance, prehension, mastication and swallowing of food, and movement Pupillary Light Response, Pupil Size (Midbrain, Cranial and coordination of the trunk and limbs. Dysfunc- Nerves II, III) tion of the brainstem and/or cranial nerves therefore In the normal horse, pupil size reflects the balance of manifests in a great variety of ways including re- sympathetic (dilator) and parasympathetic (con- duced consciousness, ataxia, limb weakness, dys- strictor) influences on the smooth muscle of the phagia, facial paralysis, jaw weakness, nystagmus, iris.2–4 Preganglionic neurons for sympathetic and strabismus. Careful neurologic examination supply to the head arise in the gray matter of the in the field can provide accurate localization of first four thoracic segments of the spinal cord and brainstem and cranial nerve lesions. Recognition subsequently course rostrally in the cervical sympa- of brainstem/cranial nerve dysfunction is an impor- thetic nerve within the vagosympathetic trunk. -
Use of Calcium-Binding Proteins to Map Inputs in Vestibular Nuclei of the Gerbil
THE JOURNAL OF COMPARATIVE NEUROLOGY 386:317–327 (1997) Use of Calcium-Binding Proteins to Map Inputs in Vestibular Nuclei of the Gerbil GOLDA ANNE KEVETTER* AND ROBERT B. LEONARD Departments of Otolaryngology, Anatomy and Neurosciences, and Physiology and Biophysics, University of Texas Medical Branch, Galveston, Texas 77555 ABSTRACT We wished to determine whether calbindin and/or calretinin are appropriate markers for vestibular afferents, a population of neurons in the vestibular nuclear complex, or cerebellar Purkinje inputs. To accomplish this goal, immunocytochemical staining was observed in gerbils after lesions of the vestibular nerve central to the ganglion, the cerebellum, or both. Eleven to fourteen days after recovery, the brain was processed for immunocytochemical identification of calretinin and calbindin. After lesion of the vestibular nerve, no calretinin staining was seen in any of the vestibular nuclei except for a population of intrinsic neurons, which showed no obvious change in number or staining pattern. Calbindin staining was reduced in all nuclei except the dorsal part of the lateral vestibular nuclei. The density of staining of each marker, measured in the magnocellular medial vestibular nucleus, was signifi- cantly reduced. After the cerebellar lesion, no differences in calretinin staining were noted. However, calbindin staining was greatly reduced in all nuclei. The density of staining, measured in the caudal medial vestibular nucleus, was significantly lower. After a combined lesion of the cerebellum and vestibular nerve, the distribution and density of calretinin staining resembled that after vestibular nerve section alone, whereas calbindin staining was no longer seen. This study demonstrates that calretinin and calbindin are effective markers for the identification of vestibular afferents. -
Cranial Nerves 1, 5, 7-12
Cranial Nerve I Olfactory Nerve Nerve fiber modality: Special sensory afferent Cranial Nerves 1, 5, 7-12 Function: Olfaction Remarkable features: – Peripheral processes act as sensory receptors (the other special sensory nerves have separate Warren L Felton III, MD receptors) Professor and Associate Chair of Clinical – Primary afferent neurons undergo continuous Activities, Department of Neurology replacement throughout life Associate Professor of Ophthalmology – Primary afferent neurons synapse with secondary neurons in the olfactory bulb without synapsing Chair, Division of Neuro-Ophthalmology first in the thalamus (as do all other sensory VCU School of Medicine neurons) – Pathways to cortical areas are entirely ipsilateral 1 2 Crania Nerve I Cranial Nerve I Clinical Testing Pathology Anosmia, hyposmia: loss of or impaired Frequently overlooked in neurologic olfaction examination – 1% of population, 50% of population >60 years Aromatic stimulus placed under each – Note: patients with bilateral anosmia often report nostril with the other nostril occluded, eg impaired taste (ageusia, hypogeusia), though coffee, cloves, or soap taste is normal when tested Note that noxious stimuli such as Dysosmia: disordered olfaction ammonia are not used due to concomitant – Parosmia: distorted olfaction stimulation of CN V – Olfactory hallucination: presence of perceived odor in the absence of odor Quantitative clinical tests are available: • Aura preceding complex partial seizures of eg, University of Pennsylvania Smell temporal lobe origin -
Cranial Nerve VIII
Cranial Nerve VIII Color Code Important (The Vestibulo-Cochlear Nerve) Doctors Notes Notes/Extra explanation Please view our Editing File before studying this lecture to check for any changes. Objectives At the end of the lecture, the students should be able to: ✓ List the nuclei related to vestibular and cochlear nerves in the brain stem. ✓ Describe the type and site of each nucleus. ✓ Describe the vestibular pathways and its main connections. ✓ Describe the auditory pathway and its main connections. Due to the difference of arrangement of the lecture between the girls and boys slides we will stick to the girls slides then summarize the pathway according to the boys slides. Ponto-medullary Sulcus (cerebello- pontine angle) Recall: both cranial nerves 8 and 7 emerge from the ventral surface of the brainstem at the ponto- medullary sulcus (cerebello-pontine angle) Brain – Ventral Surface Vestibulo-Cochlear (VIII) 8th Cranial Nerve o Type: Special sensory (SSA) o Conveys impulses from inner ear to nervous system. o Components: • Vestibular part: conveys impulses associated with body posture ,balance and coordination of head & eye movements. • Cochlear part: conveys impulses associated with hearing. o Vestibular & cochlear parts leave the ventral surface* of brain stem through the pontomedullary sulcus ‘at cerebellopontine angle*’ (lateral to facial nerve), run laterally in posterior cranial fossa and enter the internal acoustic meatus along with 7th (facial) nerve. *see the previous slide Auditory Pathway Only on the girls’ slides 04:14 Characteristics: o It is a multisynaptic pathway o There are several locations between medulla and the thalamus where axons may synapse and not all the fibers behave in the same manner. -
Auditory Nerve.Pdf
1 Sound waves from the auditory environment all combine in the ear canal to form a complex waveform. This waveform is deconstructed by the cochlea with respect to time, loudness, and frequency and neural signals representing these features are carried into the brain by the auditory nerve. It is thought that features of the sounds are processed centrally along parallel and hierarchical pathways where eventually percepts of the sounds are organized. 2 In mammals, the neural representation of acoustic information enters the brain by way of the auditory nerve. The auditory nerve terminates in the cochlear nucleus, and the cochlear nucleus in turn gives rise to multiple output projections that form separate but parallel limbs of the ascending auditory pathways. How the brain normally processes acoustic information will be heavily dependent upon the organization of auditory nerve input to the cochlear nucleus and on the nature of the different neural circuits that are established at this early stage. 3 This histology slide of a cat cochlea (right) illustrates the sensory receptors, the auditory nerve, and its target the cochlear nucleus. The orientation of the cut is illustrated by the pink line in the drawing of the cat head (left). We learned about the relationship between these structures by inserting a dye-filled micropipette into the auditory nerve and making small injections of the dye. After histological processing, stained single fibers were reconstruct back to their origin, and traced centrally to determine how they terminated in the brain. We will review the components of the nerve with respect to composition, innervation of the receptors, cell body morphology, myelination, and central terminations. -
Imaging Features Differentiating Vestibular Ganglion From
Click HERE for more articles at Annals, Academy of Medicine, Singapore homepage Differentiating Ganglion from Schwannoma—Yi-Wei Wu et al 65 Original Article Imaging Features Differentiating Vestibular Ganglion from Intracanalicular Schwannoma on Single-Sequence Non-Contrast Magnetic Resonance Imaging Study 1 1 1 2 Yi-Wei Wu, MD, MMed, FRCR, Amit Karandikar, MBBS, FRCR, FAMS, Julian PN Goh, MBBS, FRCR, Tiong Yong Tan, MBBS, FRCR, FAMS Abstract Introduction: This study aimed to identify imaging features on single-sequence non- contrast magnetic resonance imaging (MRI) that differentiate the vestibular ganglion from small intracanalicular schwannomas. Materials and Methods: Ninety patients (42 men and 48 women; age: 24‒87 years old) with 102 internal auditory canal (IAC) nodules (59 vestibular ganglia and 43 intracanalicular schwannoma) who underwent both single- sequence T2-weighted (T2W) non-contrast enhanced MRI studies and contrast-enhanced T1-weighted (T1W) MRI studies between May 2012 and April 2017 were evaluated. The length, width, distance to the IAC fundus and length/width ratios for all lesions were obtained and compared among groups. Diagnostic performance and cutoff values of the parameters were evaluated with receiver operating characteristics curve analysis. Area under the curve (AUC) value was calculated. Results: Vestibular ganglia have significantly smaller lengths and widths compared to intracanalicular vestibular schwannomas (1.7 ± 0.4 mm and 1.0 ± 0.2 mm versus 5.6 ± 3.0 mm and 3.7 ± 1.5 mm). They are more fusiform in shape compared to vestibular schwannomas (length/width ratio: 1.8 ± 0.4 versus 1.5 ± 0.4). The lesion width demonstrated the highest diagnostic performance (AUC: 0.998). -
Anatomy of the Ear ANATOMY & Glossary of Terms
Anatomy of the Ear ANATOMY & Glossary of Terms By Vestibular Disorders Association HEARING & ANATOMY BALANCE The human inner ear contains two divisions: the hearing (auditory) The human ear contains component—the cochlea, and a balance (vestibular) component—the two components: auditory peripheral vestibular system. Peripheral in this context refers to (cochlea) & balance a system that is outside of the central nervous system (brain and (vestibular). brainstem). The peripheral vestibular system sends information to the brain and brainstem. The vestibular system in each ear consists of a complex series of passageways and chambers within the bony skull. Within these ARTICLE passageways are tubes (semicircular canals), and sacs (a utricle and saccule), filled with a fluid called endolymph. Around the outside of the tubes and sacs is a different fluid called perilymph. Both of these fluids are of precise chemical compositions, and they are different. The mechanism that regulates the amount and composition of these fluids is 04 important to the proper functioning of the inner ear. Each of the semicircular canals is located in a different spatial plane. They are located at right angles to each other and to those in the ear on the opposite side of the head. At the base of each canal is a swelling DID THIS ARTICLE (ampulla) and within each ampulla is a sensory receptor (cupula). HELP YOU? MOVEMENT AND BALANCE SUPPORT VEDA @ VESTIBULAR.ORG With head movement in the plane or angle in which a canal is positioned, the endo-lymphatic fluid within that canal, because of inertia, lags behind. When this fluid lags behind, the sensory receptor within the canal is bent. -
M. Dauzvardis, Phd. 7/10/12 NERVES LISTED ACCORDING to FUNCTIONAL COMPONENTS
M. Dauzvardis, PhD. 7/10/12 NERVES LISTED ACCORDING TO FUNCTIONAL COMPONENTS SPECIAL SOMATIC AFFERENT (SSA) II. Optic: Optic stimuli are received by the rods and cones, relayed to second and third order neurons which comprise the optic nerve. (About half the fibers decussate in the optic chiasma). Impulses are along the optic nerve and optic tract to the lateral geniculate bodies of the diecephalon. Relay is then from the lateral geniculate bodies to the calcarine fissure area of the occipital lobes. VIII. Auditory (Acoustic) (Vestibulocochlear) A. Sound stimulates hair cells (receptors) of the Organ of Corti in the cochlea and impulses are carried along bipolar neurons with their cell bodies in the spiral ganglion to the dorsal and ventral cochlear nuclei of the medulla (hearing). B. Motion of the endolymph stimulates receptors in the sacculus and utriculus and the ampullae of the three semicircular canals. These impulses are carried along bipolar neurons whose cell bodies are in the vestibular ganglion and terminate in the medial, lateral, superior and spinal vestibular nuclei of the medulla (equilibrium). GENERAL SOMATIC AFFERENT (GSA) V. Trigeminal Ophthalmic branch: from cornea, conjunctiva, eyelid, forehead and nose. Maxillary branch: from skin of cheek, lower lid, side of nose and upper jaw, upper teeth, mucosa of mouth and maxillary sinuses. Mandibular branch: from skin of ear pinna, ear canal, temporal area, lower jaw and teeth, mucosa of mouth, gums and general sensation from anterior two‐thirds of the tongue. All of the above neurons have their cell bodies in the trigeminal ganglion and terminate in the sensory nuclei of the 5th nerve. -
Auditory & Vestibular Systems Steven Mcloon Department of Neuroscience University of Minnesota
Auditory & Vestibular Systems Steven McLoon Department of Neuroscience University of Minnesota 1 The auditory & vestibular systems have many similarities. • The sensory apparatus for both are in canals embedded in the bone of the inner ear. • Receptor cells (hair cells) for both are mechanosensory cells with fine stereocilia. • Information for both is carried into the brain via the vestibulochoclear nerve (cranial nerve VIII). 2 Auditory System • The auditory system detects and interprets sound. • Sound is the vibration of air molecules similar to ripples in water that propagate from a thrown rock. • The sound waves have an amplitude (loudness) and frequency (pitch). 3 Auditory System • Humans can typically hear 20 – 20,000 hertz (cycles per second). 4 Auditory System • Humans can typically hear 20 – 20,000 hertz (cycles per second). http://en.wikipedia.org/wiki/Audio_frequency 5 Auditory System • As a person ages, he/she loses the ability to hear high and low frequencies. 6 Auditory System External ear: • includes the pinna, external auditory meatus (ear canal) and tympanic membrane (ear drum). • The pinna and canal collect sound and guide it to the tympanic membrane. • The tympanic membrane vibrates in response to sound. 7 Auditory System Middle ear: • It is an air filled chamber. • The eustachian tube (auditory tube) connects the middle ear chamber with the pharynx (throat). • Three tiny bones in the chamber transfer the vibration of the tympanic membrane to the oval window of the inner ear. • Two tiny muscles can dampen the movement of the tympanic membrane and bones to protect against a loud sound. 8 Auditory System Inner ear: • The cochlea is a snail shaped tube incased in bone.