Acoustically Responsive Fibers in the Vestibular Nerve of the Cat
Total Page:16
File Type:pdf, Size:1020Kb
Load more
Recommended publications
-
Pathophysiological Mechanisms and Functional Hearing Consequences of Auditory Neuropathy
doi:10.1093/brain/awv270 BRAIN 2015: 138; 3141–3158 | 3141 REVIEW ARTICLE Pathophysiological mechanisms and functional hearing consequences of auditory neuropathy Gary Rance1 and Arnold Starr2 The effects of inner ear abnormality on audibility have been explored since the early 20th century when sound detection measures were first used to define and quantify ‘hearing loss’. The development in the 1970s of objective measures of cochlear hair cell Downloaded from function (cochlear microphonics, otoacoustic emissions, summating potentials) and auditory nerve/brainstem activity (auditory brainstem responses) have made it possible to distinguish both synaptic and auditory nerve disorders from sensory receptor loss. This distinction is critically important when considering aetiology and management. In this review we address the clinical and pathophysiological features of auditory neuropathy that distinguish site(s) of dysfunction. We describe the diagnostic criteria for: (i) presynaptic disorders affecting inner hair cells and ribbon synapses; (ii) postsynaptic disorders affecting unmyelinated auditory http://brain.oxfordjournals.org/ nerve dendrites; (iii) postsynaptic disorders affecting auditory ganglion cells and their myelinated axons and dendrites; and (iv) central neural pathway disorders affecting the auditory brainstem. We review data and principles to identify treatment options for affected patients and explore their benefits as a function of site of lesion. 1 Department of Audiology and Speech Pathology, The University of Melbourne, -
Projections from the Trigeminal Nuclear Complex to the Cochlear Nuclei: a Retrograde and Anterograde Tracing Study in the Guinea Pig
Journal of Neuroscience Research 78:901–907 (2004) Projections From the Trigeminal Nuclear Complex to the Cochlear Nuclei: a Retrograde and Anterograde Tracing Study in the Guinea Pig Jianxun Zhou and Susan Shore* Department of Otolaryngology and Kresge Hearing Research Institute, University of Michigan, Ann Arbor, Michigan In addition to input from auditory centers, the cochlear cuneate nucleus innervation of cochlear nucleus has been nucleus (CN) receives inputs from nonauditory centers, hypothesized to convey information about head and pinna including the trigeminal sensory complex. The detailed position for the purpose of localizing a sound source in anatomy, however, and the functional implications of the space (Young et al., 1995). In addition, interactions be- nonauditory innervation of the auditory system are not tween somatosensory and auditory systems have been fully understood. We demonstrated previously that the linked increasingly to phantom sound perception, also trigeminal ganglion projects to CN, with terminal labeling known as tinnitus. This is demonstrated in the observa- most dense in the marginal cell area and secondarily in tions that injuries of the head and neck region can lead to the magnocellular area of the ventral cochlear nucleus the onset of tinnitus in patients with no hearing loss (VCN). We continue this line of study by investigating the (Lockwood et al., 1998). projection from the spinal trigeminal nucleus to CN in We demonstrated previously projections from the guinea pig. After injections of the retrograde tracers Flu- trigeminal ganglion to CN in guinea pigs (Shore et al., oroGold or biotinylated dextran amine (BDA) in VCN, 2000). Terminal labeling of trigeminal ganglion projec- labeled cells were found in the spinal trigeminal nuclei, tions to the CN was found to be most dense in the most densely in the pars interpolaris and pars caudalis marginal cell area and secondarily in the magnocellular with ipsilateral dominance. -
Thresholds of Audibility for Bone-Conduction Headsets
Proceedings of ICAD 05-Eleventh Meeting of the International Conference on Auditory Display, Limerick, Ireland, July 6-9, 2005 THRESHOLDS OF AUDIBILITY FOR BONE-CONDUCTION HEADSETS Bruce N. Walker and Raymond M. Stanley Sonification Lab, School of Psychology Georgia Institute of Technology 654 Cherry Street Atlanta, Georgia USA 30332. [email protected], [email protected] ABSTRACT input jack, these newer “bonephones” are now suitable for implementation in auditory displays. The transducers of the Despite advantages of using headphones, including privacy and bonephones rest on the mastoid, which is the raised portion of portability, headphones have one essential drawback: they cover the temporal bone located directly behind the ear. The mastoid the ears of the listener, thus deteriorating detection and is a preferable transducer location relative to the forehead or localization of ambient sounds. Bone-conduction headsets leave temple because it contains the inner ear, is relatively immune to the ears uncovered, yet maintain portability and privacy. An the interference associated with muscle tissue operating the jaw, initial step in establishing guidelines for using these and allows stereo presentation of sounds. “bonephones” is taken in the present research. The input into the bonephones necessary to reach a 71% detection threshold is measured at critical band centers ranging from 150 Hz to 13500 1.2. The Need For Bone-conduction Research Hz. These thresholds were measured with an open ear canal, a plugged ear canal, and a masking noise. Results were consistent Most of psychoacoustics research and all of the human factors with other bone-conduction threshold measurements. The utility research on auditory displays that the authors are aware of has of this information in the context of equalization for the audio focused on the conduction of sound through air, and thus has presented through the bonephones is discussed. -
Direct Projections from Cochlear Nuclear Complex to Auditory Thalamus in the Rat
The Journal of Neuroscience, December 15, 2002, 22(24):10891–10897 Direct Projections from Cochlear Nuclear Complex to Auditory Thalamus in the Rat Manuel S. Malmierca,1 Miguel A. Mercha´n,1 Craig K. Henkel,2 and Douglas L. Oliver3 1Laboratory for the Neurobiology of Hearing, Institute for Neuroscience of Castilla y Leo´ n and Faculty of Medicine, University of Salamanca, 37007 Salamanca, Spain, 2Wake Forest University School of Medicine, Department of Neurobiology and Anatomy, Winston-Salem, North Carolina 27157-1010, and 3University of Connecticut Health Center, Department of Neuroscience, Farmington, Connecticut 06030-3401 It is known that the dorsal cochlear nucleus and medial genic- inferior colliculus and are widely distributed within the medial ulate body in the auditory system receive significant inputs from division of the medial geniculate, suggesting that the projection somatosensory and visual–motor sources, but the purpose of is not topographic. As a nonlemniscal auditory pathway that such inputs is not totally understood. Moreover, a direct con- parallels the conventional auditory lemniscal pathway, its func- nection of these structures has not been demonstrated, be- tions may be distinct from the perception of sound. Because cause it is generally accepted that the inferior colliculus is an this pathway links the parts of the auditory system with prom- obligatory relay for all ascending input. In the present study, we inent nonauditory, multimodal inputs, it may form a neural have used auditory neurophysiology, double labeling with an- network through which nonauditory sensory and visual–motor terograde tracers, and retrograde tracers to investigate the systems may modulate auditory information processing. -
Use of High-Frequency and Muscle Vibration in the Treatment of Tinnitus
International Tinnitus Journal, Vol. 9, No.1, 32-36 (2003) Use of High-Frequency and Muscle Vibration in the Treatment of Tinnitus Martin L. Lenhardt,1,2 Barbara A. Goldstein,2,3 Abraham Shulman,2,3 and Robert Guinta2,3 IProgram in Biomedical Engineering, Virginia Commonwealth University, Richmond, VA; 2Sound Technique Systems, LLC; and 3Martha Entenmann Tinnitus Research Center, State University of New York, Brooklyn, NY Abstract: Although tinnitus is defined as an internal auditory sensation, external auditory stimuli can mask tinnitus under some circumstances. High-frequency vibration delivered as bone conduction stimulation is effective in masking high-pitched tinnitus. In this preliminary report, somatosensory stimulation in the form of low-frequency muscle vibration can also mask high-frequency tinnitus. Somatosensory stimulation provides fast, immediate relief, whereas high-frequency vibration provides longer-lasting benefit. Either modality can stand alone or can be used in conjunction for tinnitus treatment. A clinically feasible technique has been iden tified for more wide-scale evaluation. Key Words: hallucinations; high-frequency vibration; somatosensory; tinnitus; tinnitus model n a we\l-known experiment, von Bekesy [1] can only partially overlap with their tinnitus pitch , appar I celed the perception of an air-conducted pure tone ently masking can be effective regardless of whether with a second tone of the same frequency pre the masker contains the tinnitus frequencies [9]. sented simultaneously to the ear by bone conduction. This outcome is just the opposite in cochlear mask The trick was to alter the phase, canceling the stimula ing. The more a masker is frequency-separated from tion in the cochlea. -
Common Vestibular Function Tests
Common Vestibular Function Tests Authors: Barbara Susan Robinson, PT, DPT; Lisa Heusel-Gillig PT DPT NCS Fact Sheet The purpose of Vestibular Function Tests (VFTs) is to determine the health of the vestibular portion of the inner ear. These tests are commonly performed by ENTs, Audiologists, and Otolaryngologists Electronystagmography or Videonystagmography Electronystagmography (ENG test) or Videonystagmography (VNG test) evaluate the inner ear. Both record eye movements during a group of tests in light and dark rooms. During the ENG test, small electrodes are placed on the skin near the eyes to record eye movements. For the VNG test, eye movements are recorded by a video camera mounted inside of goggles that are worn during testing. ENG and VNG tests evaluate eye movements while following a visual target (tracking Produced by test) or during body and head position changes (positional test). The caloric test evaluates eye movements in response to cool or warm air (or water) placed in the ear canal. If there is no response to warm or cool air or water, ice water may be used in order to try to produce a response. The caloric test determines the difference between the function of the left and right inner ear. During this test, you may experience dizziness or nausea. You may be asked questions (math questions, city names, alphabet tasks) to distract you in order to get the best results. A Special Interest Group of Contact us: ANPT Other Common Vestibular Function Tests 5841 Cedar Lake Rd S. The rotary chair test is used along with the VNG to confirm the diagnosis and assess Ste 204 compensation of the vestibular system. -
Bone Conduction Hearing: a Natural Pathway to Hearing
BoneBone ConductionConduction Hearing:Hearing: A Natural Pathway to Hearing George Cire, Au.D [email protected] Donna Sorkin, M.A. [email protected] GeorgeGeorge Cire,Cire, Au.D.Au.D. • Fellow, American Academy of Audiology • Member and CCC/A, ASHA • Clinical Manager, Bone Anchored Solutions, Cochlear Americas • Award for Continuing Education, ASHA • Previously, Member of TX Board of Examiners in Speech Pathology & Audiology • Thirty years serving as an Audiologist in both private practice and industry DonnaDonna Sorkin,Sorkin, M.A.M.A. • Vice President, Consumer Affairs, Cochlear Americas • Manage Cochlear Americas HOPE program • Address public policy issues impacting our recipient community • Previously, Executive Director of HLAA and AG Bell • Advocate for consumers and families PresentationPresentation topicstopics z How the Ear works z Types of Hearing Loss z Audiogram Patterns z Possible causes for each type of Hearing loss z Treatment Options z Bone Conduction Hearing Devices z Case Studies z How Early Intervention can help a child who may be a candidate for bone conduction hearing MajorMajor DivisionsDivisions ofof thethe EarEar z Outer Ear (Pinna and Ear Canal) z Middle Ear (Eardrum, Ossicular Chain) z Inner Ear (Cochlea) TheThe EarEar TypesTypes ofof HearingHearing lossloss z Conductive z Sensorineural z Mixed TheThe EarEar TheThe HearingHearing EvaluationEvaluation z A primary goal of the clinical evaluation of hearing is to identify the type and severity of the hearing loss z Done by testing both the air conduction and -
Vestibular Neuritis, Labyrinthitis, and a Few Comments Regarding Sudden Sensorineural Hearing Loss Marcello Cherchi
Vestibular neuritis, labyrinthitis, and a few comments regarding sudden sensorineural hearing loss Marcello Cherchi §1: What are these diseases, how are they related, and what is their cause? §1.1: What is vestibular neuritis? Vestibular neuritis, also called vestibular neuronitis, was originally described by Margaret Ruth Dix and Charles Skinner Hallpike in 1952 (Dix and Hallpike 1952). It is currently suspected to be an inflammatory-mediated insult (damage) to the balance-related nerve (vestibular nerve) between the ear and the brain that manifests with abrupt-onset, severe dizziness that lasts days to weeks, and occasionally recurs. Although vestibular neuritis is usually regarded as a process affecting the vestibular nerve itself, damage restricted to the vestibule (balance components of the inner ear) would manifest clinically in a similar way, and might be termed “vestibulitis,” although that term is seldom applied (Izraeli, Rachmel et al. 1989). Thus, distinguishing between “vestibular neuritis” (inflammation of the vestibular nerve) and “vestibulitis” (inflammation of the balance-related components of the inner ear) would be difficult. §1.2: What is labyrinthitis? Labyrinthitis is currently suspected to be due to an inflammatory-mediated insult (damage) to both the “hearing component” (the cochlea) and the “balance component” (the semicircular canals and otolith organs) of the inner ear (labyrinth) itself. Labyrinthitis is sometimes also termed “vertigo with sudden hearing loss” (Pogson, Taylor et al. 2016, Kim, Choi et al. 2018) – and we will discuss sudden hearing loss further in a moment. Labyrinthitis usually manifests with severe dizziness (similar to vestibular neuritis) accompanied by ear symptoms on one side (typically hearing loss and tinnitus). -
Diseases of the Brainstem and Cranial Nerves of the Horse: Relevant Examination Techniques and Illustrative Video Segments
IN-DEPTH: NEUROLOGY Diseases of the Brainstem and Cranial Nerves of the Horse: Relevant Examination Techniques and Illustrative Video Segments Robert J. MacKay, BVSc (Dist), PhD, Diplomate ACVIM Author’s address: Alec P. and Louise H. Courtelis Equine Teaching Hospital, College of Veterinary Medicine, University of Florida, Gainesville, FL 32610; e-mail: mackayr@ufl.edu. © 2011 AAEP. 1. Introduction (pons and cerebellum) and myelencephalon (me- This lecture focuses on the functions of the portions dulla oblongata). Because the diencephalon was of the brainstem caudal to the diencephalon. In discussed in the previous lecture under Forebrain addition to regulation of many of the homeostatic Diseases, it will not be covered here. mechanisms of the body, this part of the brainstem controls consciousness, pupillary diameter, eye 3. Functions (Location) movement, facial expression, balance, prehension, mastication and swallowing of food, and movement Pupillary Light Response, Pupil Size (Midbrain, Cranial and coordination of the trunk and limbs. Dysfunc- Nerves II, III) tion of the brainstem and/or cranial nerves therefore In the normal horse, pupil size reflects the balance of manifests in a great variety of ways including re- sympathetic (dilator) and parasympathetic (con- duced consciousness, ataxia, limb weakness, dys- strictor) influences on the smooth muscle of the phagia, facial paralysis, jaw weakness, nystagmus, iris.2–4 Preganglionic neurons for sympathetic and strabismus. Careful neurologic examination supply to the head arise in the gray matter of the in the field can provide accurate localization of first four thoracic segments of the spinal cord and brainstem and cranial nerve lesions. Recognition subsequently course rostrally in the cervical sympa- of brainstem/cranial nerve dysfunction is an impor- thetic nerve within the vagosympathetic trunk. -
Speech Reception Via Bone Conduction
Portland State University PDXScholar Dissertations and Theses Dissertations and Theses 1989 Speech reception via bone conduction Sherry G. Morris Portland State University Follow this and additional works at: https://pdxscholar.library.pdx.edu/open_access_etds Part of the Speech and Hearing Science Commons Let us know how access to this document benefits ou.y Recommended Citation Morris, Sherry G., "Speech reception via bone conduction" (1989). Dissertations and Theses. Paper 3908. https://doi.org/10.15760/etd.5792 This Thesis is brought to you for free and open access. It has been accepted for inclusion in Dissertations and Theses by an authorized administrator of PDXScholar. Please contact us if we can make this document more accessible: [email protected]. AN ABSTRACT OF THE THESIS OF Sherry G. Morris for the Master of Science in Speech Communication presented May 5, 1989. Title: Speech Reception via Bone Conduction. APPROVED BY THE MEMBERS OF THE THESIS COMMITTEE: Tb6mas D~n, Chair _/ ~ '!'he purpose of this investigation was to determine if the performance-intensity function for spondees deli- vere~ via bone conduction (using the Radioear E-72 and Pracitronic KH-70) differed from the performance-intensity function for air conduction (using TDH-39 earphones). A secondary consideration addressed in this study was the comparison ~= the discrimination sccrcs using the three transdu;::ers. Performance-intensity funC"tions for spondee thresho:ds were calculated on 12 normal hearing subjects 2 using two bone conduction vibrators, the Radioear B-72 and Pracitronic KH-70, and TDH-39 earphones. Results indicated that there was no significant difference between the performance-intensity function of speech via bone conduction as compared to speech via air conduction. -
Auditory and Vestibular Systems Objective • to Learn the Functional
Auditory and Vestibular Systems Objective • To learn the functional organization of the auditory and vestibular systems • To understand how one can use changes in auditory function following injury to localize the site of a lesion • To begin to learn the vestibular pathways, as a prelude to studying motor pathways controlling balance in a later lab. Ch 7 Key Figs: 7-1; 7-2; 7-4; 7-5 Clinical Case #2 Hearing loss and dizziness; CC4-1 Self evaluation • Be able to identify all structures listed in key terms and describe briefly their principal functions • Use neuroanatomy on the web to test your understanding ************************************************************************************** List of media F-5 Vestibular efferent connections The first order neurons of the vestibular system are bipolar cells whose cell bodies are located in the vestibular ganglion in the internal ear (NTA Fig. 7-3). The distal processes of these cells contact the receptor hair cells located within the ampulae of the semicircular canals and the utricle and saccule. The central processes of the bipolar cells constitute the vestibular portion of the vestibulocochlear (VIIIth cranial) nerve. Most of these primary vestibular afferents enter the ipsilateral brain stem inferior to the inferior cerebellar peduncle to terminate in the vestibular nuclear complex, which is located in the medulla and caudal pons. The vestibular nuclear complex (NTA Figs, 7-2, 7-3), which lies in the floor of the fourth ventricle, contains four nuclei: 1) the superior vestibular nucleus; 2) the inferior vestibular nucleus; 3) the lateral vestibular nucleus; and 4) the medial vestibular nucleus. Vestibular nuclei give rise to secondary fibers that project to the cerebellum, certain motor cranial nerve nuclei, the reticular formation, all spinal levels, and the thalamus. -
Anatomy of the Superior Olivary Complex.Pdf
Douglas Oliver University of Connecticut Health Center SUPERIOR OLIVE Auditory Pathways Auditory CORTEX GLUT Cortex GABA GLY Medial Geniculate MGB Body Inferior IC Colliculus DLL DLL COCHLEA VLL VLL DCN VCN SOC Auditory Pathways IC Organization of Superior Olivary Complex . Subdivisions and Cytoarchitecture . Neuron types . Inputs . Outputs . Synapses . Basic Circuit Cytoarchitecture of Superior Olivary Complex LSO LSO MSO MSO MNTB D MNTB M (somata & dendrites) (axons & endings) Tsuchitani, 1978, Fig. 10 Comparative anatomy of SOC Tetsufumi Ito & Shig Kuwada Binaural Basic Circuits 8 ‐ 9 Brodal Fig MSO: medial superior olive; LSO: lateral superior olive NTB: nucleus of trapezoid body; IC: inferior colliculus MSO Principle glutamate Cells . Fusiform . Bipolar . Disc‐shaped . Each dendrite innervated by a different side MSO‐In situ hybridization RPO MSO MNTB SPO LSO VGLUT1 VGLUT2 VIAAT NISSL MSO Inputs and Synapses H=high frequency EI - ILD L=low frequency EE - ITD LSO MSO L L B H B B H G LNTB TO LSO MNTB E=Excitation (glutamate) ‐‐‐ I=Inhibition (glycine) ITD CODING Unlike retinal targets, the cochlear nuclei contain maps of frequency, not location. So how does the auditory system know ‘where’ a sound is coming from? T + ITD T By comparing the interaural time differences (ITD) between the ears How is this accomplished?... LSO MSO Right Input A Right Input B C Time Code Time Code E E A A B B C C D D E E Output Output abcde Place Code abcde Place Code Excitation MSO creates a response to Left Input Left Input Inhibition interaural time differences I Time Code E Time Code DEMSO "peak" unit LSO "trough" unit ITD ITD Figure 14.2 Binaural Responses in MSO MSO Summary .