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Descargar Memoria Completa INDEX 6 1. Presentation 132 NEC.9 Brain Mapping 7 2. Structure 134 NEC.11 Neural Plasticity 10 3. Research Structure 135 NEC.12 Pharmacology on Neurosecretion (FARMASER) 15 4. Training Activites 137 NEC.13 Neurotransmission and Purinergic Signaling 21 5. Research grant proposals 139 NEC.14 DEDINUC. Degeneration and Differentiation 26 6. Active projects 2016 through Nucleotides 27 7. Human Resources: 140 NEC.17 Neurobiology of Hearing 29 8. Other scientifi c activity data 141 NEC.18 Research in Glaucoma, Retina 29 9. Technological transference activity and Visual Pathways 30 10. Scientifi c dissemination activities 149 NEC.20 Neurotransmission and Neuromodulation 31 11. Bibliometric analysis in the Central and Peripheral Nervous System 37 12. Economic Activity 152 NEC.21 Pharmaceutical Innovation in Ophthalmology 154 NEC.22 Pathophysiology and INA Neurological CARDIOVASCULAR AREA (CV) Therapeutics (NEURO-INA-IN) 41 CV.1 Technology Assessment and Therapeutic ONCOLOGY (ONC) Strategies in Coronary Arteriosclerosis 48 CV.2 Cardiovascular Imaging 159 ONC.1 Clinical and Translational Research in Oncology 51 CV.4 Arrhythmia 184 ONC.2 Cancer and Obesity 54 CV.6 Cardiovascular Research Unit 187 ONC.3 Pathological Anatomy 57 CV.7 ValvularPathology and Large Vessels 189 ONC.4 Cell Signaling Mechanisms during Development 60 CV.8 Translational Research in Acute Myocardial and Tumor Progression Syndromes (INTEGRA) 191 ONC.5 Cannabinoid Signaling in Tumor Cells 66 CV.10 Myocardial Regeneration Therapy 70 CV.11 Cardiovascular Risk OTHER LARGE SYSTEMS AREA (OGS) 73 CV.12 Vascular Biology 197 OGS.1 Brain Glucose Sensors, Control of Satiety, Obesity and Type 2 Diabetes INFLAMMATION, INFECTION, 199 OGS.5 Sports Medicine IMMUNITY AND ALLERGY AREA (IIIA) 201 OGS.6 Diabetes and Cardiovascular 79 IIIA.1 Allergy 203 OGS.9 Endocrinology of Metabolic Diseases 83 IIIA.2 Immunology 206 OGS.10 Obesity and Vascular Risk 86 IIIA.3 Musculoskeletal Pathology 209 OGS.12 Clinical Pharmacology 90 IIIA.6 Research on Sexually Transmitted Diseases 212 OGS.13 Technology, design and Surgical Innovation and HIV 214 OGS.14 Medical Physics 94 IIIA.7 Molecular and Epidemiological Study 216 OGS.15 Aging of Resistant Microorganisms of Clinical Interest 218 OGS.16 Diabetes Mellitus / Obesity 97 IIIA.08 Kidney transplant 220 OGS.17 Biomedical Imaging Research 101 IIIA.09 Infectious Diseases/HIV 222 OGS.18 Health Care Research 104 IIIA.10 Research on INA Infectious Disease 224 OGS.19 Epidemiology and Health Services 108 IIIA.11 Cell-biomaterial Interactions (BIO UCM) 228 OGS.20 Prevention of Occupational Hazards 230 OGS.21 Research in Urology. Cancer and New Therapies NEUROSCIENCE AREA (NEC) 232 OGS.22 Research in Physiotherapy 113 NEC.1 Clinical and Neurobiological Research 233 OGS.23 The Digestive System in Psychiatry and Mental Health 237 OGS.24 Hematology 115 NEC.2 Advanced Research in Personality Disorders, 240 OGS.25 Pathology of Emergency Aggression and Impulse Control 246 OGS.27 The Interdisciplinary Study Group 117 NEC.3 Psychoneuroendocrinology, Molecular of Diabetic Foot Neuroimaging and Genetics 248 OGS.29 Socioeconomic Health Determinants in Neuropsychiatric Diseases 250 OGS.30 AFUSAN 119 NEC.5 Applied Research in Neuroscience 252 OGS.31 Hematology: Megakaryopoiesis and Platelets (to: Neuromodulation and Neurorepair) 122 NEC.6 Neurological Diseases 254 Appendix I 130 NEC.7 Multiple Sclerosis 261 Appendix II Continuously pursuing for excellence in research oriented to a better patient care, the Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), aims to increase the impact and effi ciency of biomedical research. Through its structure and strategic plan, it is dedicated to identify and respond to health-related questions. This vision aligns with Spanish and European research policies and brings higher-quality scientifi c results. In 2016, the IdISSC hosted 724 scientists thriving to improve outcomes and to catalyze research across fi ve biomedical areas. They published 511 scientifi c articles with 18% of them in the fi rst deciles, and with an accumulated impact factor of 2455. Many of the IdISSC PIs work extensively with scientifi c colleagues both nationally (participating in different collaborative platforms, such as RETICs and CIBERs), and internationally with 11 EU projects. IdISSC teams conducted 585 clinical trials that push biomedical research towards a scenario where disease is treated in an individualized way. Equally important, the IdISSC investigators inspire talented young students to pursue research, and over one hundred doctoral theses were presented in 2016. The IdISSC is committed to the development and support of a research workforce that engages the ideas, creativity, and innovation from all diverse research groups. Two successful initiatives crystallized in Integrated Projects of Excellence funded by the Instituto de Salud Carlos III during 2016, one of them coordinating seven research teams from IdISSC and the other with extramural participation. Over the past year, the IdISSC aimed to accelerate the pace of discovery in biomedical research and it supported programs, featured a network of core services, and tried to generate resources to reach this objective, struggling to overcome the budgetary challenges that scientists have faced during the last decade. We all must congratulate for this common effort to leverage the intellectual capital oriented to benefi t the entire community, reduce patient suffering, and increase quality of life. Elena Urcelay Elena Urcelay García Antonio Portolés Pérez José Soto Bonel Scientic Director (IdISSC) Director (FIB HCSC) President (FIB HCSC) SCIENTIFIC REPORT 1. Presentation The Health Research Institute of the Hospital Clínico San Carlos in Madrid is an organization dedicated to promoting research, to the planning of the scientifi c activity in line with the areas defi ned in the strategic plan, to provide methodological support for conducting research projects and clinical trials, to manage people and their knowledge, to ensure the use of the infrastructure dedicated to research, to manage the resulting economic resources for research development, and to be the translating platform for research results into clinical practice. Its mission is to promote and consolidate the activities of biomedical research from groups within the Institute, building an organiza- tion of excellence for the generation of scientifi c knowledge, oriented to health care practice, and thus, improving the citizens health through the interrelation of basic and clinical research, integration of resources, the encouraging of innovation and internationali- zation, as well as the empowerment and recognition of researchers and support staff, all underpinned by a dynamic management, based on continuous improvement and learning. Its vision is to be an organization of scientifi c excellence with international visibility, conducting network research, and with a com- mitment to innovation and technological advance through the development of a sustainable research and the promotion of gender equality and internationalization. The values of the Health Research Institute of the Hospital Clínico are: accessibility, transparency, dedication to service and respect. To sum up, the research groups of interest of the Institute are: Citizens: the reason and ultimate research Researchers: basic actors for the achievement of results Participating institutions: researcher’s corporate matrix environment, without which the development of the mission would be im- possible Public and private funding agencies: essential for the development of the activity and regulators of performance standards Entities providing related services and business developers: elements able to support the fi nal application of research in the social sphere. The entities that constitute the Institute of Health Research in the Hospital Clínico San Carlos are: Hospital Clínico San Carlos (HCSC) The Hospital is the core of the Institute. Hospital Clínico San Carlos dates from 1787, being one of the oldest hospitals in Spain. At the beginning, it was located in a Madrilenian street named Atocha. Afterwards, the premises housing the Faculty of Medicine and the Hospital Clínico were built in the same location. In February 1969, the new hospital was offi cially inaugurated in the Moncloa Orchard, adapting all chairs, departments and units in order to accomplish its three goals: teaching, health care and research. In 1986, the Hospital was integrated in the Public Sector Hospital Network, and since January 1st, 2002 it belongs to the Department of Health and Consumption of the Community of Madrid. The goals of the HCSC include health care improvement, teaching and research. The center is adapted to the Madrilenian society requests, being a national and international referral hospital, due to the level of its health care facilities and professionals. Universidad Complutense de Madrid (UCM) Currently, the Universidad Complutense de Madrid has 26 Faculties, 7 Schools, 9 Associated Centers, 38 University Research Ins- titutes and 9 Professional Specialization Schools, apart from 18 Research Support Centers and ICTS; all of them mainly distributed on the Moncloa and Somosaguas campuses. Additionally, a total of 40 University Research Institutes have been created within the UCM, covering all areas of knowledge of the University (including university biomedical research institutes). 6 IdISSC Scientific Report 2016 SCIENTIFIC REPORT Fundación para la Investigación Biomédica del Hospital
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