1 Monovalent antibody-conjugated lipid-polymer nanohybrids for active 2 targeting to desmoglein 3 of keratinocytes to attenuate psoriasiform 3 inflammation 4 5 Zih-Chan Lina, Tsong-Long Hwangb,c,d,e,f, Tse-Hung Huangd,g,h,i, Kohei Taharaj, Jiří 6 Trousilk, Jia-You Fangb,c,d,f,* 7 a Graduate Institute of Biomedical Sciences, Chang Gung University, Kweishan, 8 Taoyuan, Taiwan 9 b Graduate Institute of Natural Products, Chang Gung University, Kweishan, Taoyuan, 10 Taiwan 11 c Chinese Herbal Medicine Research Team, Healthy Aging Research Center, Chang 12 Gung University, Kweishan, Taoyuan, Taiwan 13 d Research Center for Food and Cosmetic Safety and Research Center for Chinese 14 Herbal Medicine, Chang Gung University of Science and Technology, Kweishan, 15 Taoyuan, Taiwan 16 e Department of Chemical Engineering, Ming Chi University of Technology, New 17 Taipei City, Taiwan 18 f Department of Anesthesiology, Chang Gung Memorial Hospital, Kweishan, Taoyuan, 19 Taiwan 20 g Department of Traditional Chinese Medicine, Chang Gung Memorial Hospital, 21 Keelung, Taiwan 22 h School of Traditional Chinese Medicine, Chang Gung University, Kweishan, 23 Taoyuan, Taiwan 24 i School of Nursing, National Taipei University of Nursing and Health Sciences, 25 Taipei, Taiwan 26 j Laboratory of Pharmaceutical Engineering, Gifu Pharmaceutical University, Gifu, 27 Japan 28 k Institute of Macromolecular Chemistry, Czech Academy of Sciences, Prague, Czech 29 Republic 30 31 Correspondence: Jia-You Fang, Pharmaceutics Laboratory, Graduate Institute of 32 Natural Products, Chang Gung University, 259 Wen-Hwa 1st Road, Kweishan, 33 Taoyuan 333, Taiwan, Tel: +886-3-2118800, Fax:+886-3-2118236 E-mail: 34
[email protected].