The Physiologist
Total Page:16
File Type:pdf, Size:1020Kb
Load more
Recommended publications
-
The Use of Non-Human Primates in Research in Primates Non-Human of Use The
The use of non-human primates in research The use of non-human primates in research A working group report chaired by Sir David Weatherall FRS FMedSci Report sponsored by: Academy of Medical Sciences Medical Research Council The Royal Society Wellcome Trust 10 Carlton House Terrace 20 Park Crescent 6-9 Carlton House Terrace 215 Euston Road London, SW1Y 5AH London, W1B 1AL London, SW1Y 5AG London, NW1 2BE December 2006 December Tel: +44(0)20 7969 5288 Tel: +44(0)20 7636 5422 Tel: +44(0)20 7451 2590 Tel: +44(0)20 7611 8888 Fax: +44(0)20 7969 5298 Fax: +44(0)20 7436 6179 Fax: +44(0)20 7451 2692 Fax: +44(0)20 7611 8545 Email: E-mail: E-mail: E-mail: [email protected] [email protected] [email protected] [email protected] Web: www.acmedsci.ac.uk Web: www.mrc.ac.uk Web: www.royalsoc.ac.uk Web: www.wellcome.ac.uk December 2006 The use of non-human primates in research A working group report chaired by Sir David Weatheall FRS FMedSci December 2006 Sponsors’ statement The use of non-human primates continues to be one the most contentious areas of biological and medical research. The publication of this independent report into the scientific basis for the past, current and future role of non-human primates in research is both a necessary and timely contribution to the debate. We emphasise that members of the working group have worked independently of the four sponsoring organisations. Our organisations did not provide input into the report’s content, conclusions or recommendations. -
August and Marie Krogh August and Marie Krogh
August and Marie Krogh August and Marie Krogh LIVES IN SCIENCE Bodil Schmidt-Nielsen, Dr. Odont, Dr. phil. Professor Emeritus and Aqjunct Professor, Department of Physiology, University of Florida SPRINGER NEW YORK 1995 Oxford University Press Oxford New York Toronto Delhi Bombay Calcutta Madras Karachi Kuala Lumpur Singapore Hong Kong Tokyo Nairobi Dar es Salaam Cape Town Melbourne Auckland Madrid and associated companies in Berlin lbadan Copyright © 1995 by the American Physiological Society Originally published by American Physiological Society in 1995 Softcover reprint of the hardcover 1st edition 1995 Oxford is a registered trademark of Oxford University Press AII rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted, in any form or by any means, electronic, mechanical, photocopying, recording, or otherwise, without the prior permission of Oxford University Press. Library of Congress Cataloging-in-Publication Data Schmidt-Nielsen, Bodil. August and Marie Krogh : lives in science by Bodil Schmidt-Nielsen. p. cm. Includes index. ISBN 978-1-4614-7530-9 (eBook) DOI 10.1007/978-1-4614-7530-9 1. Krogh, August, 1874-1949. 2. Krogh, Marie, 1874-1943. 3. Physiologists-Denmark-Biography. I. Title. QP26.K76S35 1995 591.1'092-dc20 [B] 94-20655 9 8 7 6 5 4 3 2 1 Printed in the United States of America on acid-free paper Preface When my father August Krogh died in 1949, 1 was with him in Den mark. My stay in Denmark was prolonged for another two months due to a concussion 1 sustained in an automobile accident, which occurred shortly after his death. -
Animal Research Essay Resources 2013
Animal research essay resources 2013 Animal Research Essay Resources (Manage) and AO2 (Use Resources) assessment objectives of their EPQ. Click on one of the links below for resources on the specific area of interest surrounding the AO1 requires students to identify their topic and issue of animal testing: the project’s aims and objectives. They must then produce a project plan and complete their History of animal research work, applying organisational skills and Ethics of animal experiments strategies to meet stated objectives. This page Costs and benefits of research aims to help students get a handle on the topic Regulatory systems and the 3Rs of animal research and provide some inspiration Animal rights activism and extremism for possible areas of further study. General Websites AO2 requires students to obtain, and select Many students, from primary school to from, a variety of resources, analyse and apply university, write assignments that relate to the this data in a relevant manner and demonstrate issue of animal research. This page aims to an understanding of appropriate links. This page support this by providing links to useful will provide links to large amounts of relevant materials. It is especially useful to any students information that students can use for their carrying out the Extended Project Qualification project, however it remains up to students to (EPQ) alongside their A-levels or Extended Essay critically analyse and apply it to their specific as part of their International Baccalaureate project focus. studies. Those students should read the section below. History of animal research Beneath each link is a Harvard Reference for the The use of animals in scientific experiments in book, webpage or document in question which the UK can be traced back at least as far as the can be used in the footnotes or endnotes of 17th Century with Harvey’s experiments on your project paper. -
DMJ.1936.2.1.A02.Young.Pdf (3.644Mb)
DALHOUSIE MEDICAL JOURNAL 5 A Memorable Conference THE HARVARD TERCENTENARY 1636 - 1936 E. GORDON YOUNG, B.A., M.Sc., Ph.D., F.R.S.C. OMEONE has said that the most valuable and rarest thing in the world S is a new idea. It is the verdict or the intellectual world of science, of art and of music that progress centres largely about the thoughts ex pressed by the few great minds of the centuries. The work of the scientists of the world has been likened to a great canvas, the subject of which has been chosen by the few and the first bold lines inserted, but the great mass of colour and detail has been supplied by the many faithful apprentices. It was most fitting that the oldest and greatest of American Universities should celebrate its three hundredth birthday in an intellec tual feast and that it should invite to its table as leaders of conversation the greatest minds of the world in those subjects which were proposed for discussion. Harvard.!J.as a magnificent record of intellectual tolerance and its hospitality was open to individuals of all nationalities and all re- ligious and political creeds. To Cambridge thus in the early days of September, 1936, there came, by invitation, a group of about two thousand five hundred American and Canadian scholars to participate in a memorable series of symposia led by a special group of sixty-seven eminent scientists and men of letters from fifteen different countries. These included no fewer than eleven men who had the greatest single distinction in the realms of science and of letters, the Nobel Prize. -
100858 AVANCES 26 5Indd
avances en Diabetología Av Diabetol. 2010;26:373-82 Historical perspective From pancreatic extracts to artificial pancreas: history, science and controversies about the discovery of the pancreatic antidiabetic hormone V: The controversy. Who discovered insulin? A. de Leiva-Pérez1, E. Brugués-Brugués1,2, A. de Leiva-Hidalgo1,2,3,4 1Fundación DIABEM. 2Servicio de Endocrinología y Nutrición e Instituto de Investigación. Hospital de la Santa Creu i Sant Pau. Barcelona. 3Centro de Historia de la Ciencia. Universitat Autònoma de Barcelona. 4CIBER-BBN-ISCIII The Nobel Prize controversy were provided by two members of the objection was to making an award on “he- The 1923 Nobel Award Nobel Committee: John Sjöqvist, Profes- resy evidence” from unknown persons or of Physiology or Medicine sor of Chemistry and Pharmacy, and Hans on statements in the two appraisals, like In April 1923, a total of 57 nominations Christian Jacobaeus, Professor of Internal “it is beyond doubt”, or comments as with merits were reviewed by the Nobel Medicine. Sjökvist arrived to the same ”things that are thought as very possible”; Committee. The examiners concluded conclusion as A. Krogh: the prize should the Assembly should take only verifi able that the discovery of insulin was of funda- be divided between Banting and Macleod. facts. The Committee reconsidered and mental importance. The archives of the Professor Göran Liljstrand was the Secre- reconfirmed its previous recommenda- Karolinska Institute depict that Macleod tary of the Nobel Committee from 1918 to tion. August Krogh was identifi ed as the and Banting were nominated for the fi rst 1960. He was a great friend of August source of the “heresy evidence”; he time in 1923: Banting by G.W. -
Balcomk41251.Pdf (558.9Kb)
Copyright by Karen Suzanne Balcom 2005 The Dissertation Committee for Karen Suzanne Balcom Certifies that this is the approved version of the following dissertation: Discovery and Information Use Patterns of Nobel Laureates in Physiology or Medicine Committee: E. Glynn Harmon, Supervisor Julie Hallmark Billie Grace Herring James D. Legler Brooke E. Sheldon Discovery and Information Use Patterns of Nobel Laureates in Physiology or Medicine by Karen Suzanne Balcom, B.A., M.L.S. Dissertation Presented to the Faculty of the Graduate School of The University of Texas at Austin in Partial Fulfillment of the Requirements for the Degree of Doctor of Philosophy The University of Texas at Austin August, 2005 Dedication I dedicate this dissertation to my first teachers: my father, George Sheldon Balcom, who passed away before this task was begun, and to my mother, Marian Dyer Balcom, who passed away before it was completed. I also dedicate it to my dissertation committee members: Drs. Billie Grace Herring, Brooke Sheldon, Julie Hallmark and to my supervisor, Dr. Glynn Harmon. They were all teachers, mentors, and friends who lifted me up when I was down. Acknowledgements I would first like to thank my committee: Julie Hallmark, Billie Grace Herring, Jim Legler, M.D., Brooke E. Sheldon, and Glynn Harmon for their encouragement, patience and support during the nine years that this investigation was a work in progress. I could not have had a better committee. They are my enduring friends and I hope I prove worthy of the faith they have always showed in me. I am grateful to Dr. -
Krogh's Principle for Musculoskeletal Physiology and Pathology
Journal of Musculoskeletal J Musculoskelet Neuronal Interact 2018; 18(3):284-291 and Neuronal Interactions Perspective Article Krogh’s principle for musculoskeletal physiology and pathology Seth W. Donahue Department of Biomedical Engineering, University of Massachusetts, USA Abstract August Krogh was a comparative physiologist who used frogs, guinea pigs, cats, dogs, and horses in his research that led to his Nobel Prize on muscle physiology. His idea to choose the most relevant organism to study problems in physiology has become known as Krogh’s principle. Indeed, many important discoveries in physiology have been made using naturally occurring animal models. However, the majority of research today utilizes laboratory mouse and rat models to study problems in physiology. This paper discusses how Krogh’s principle can be invoked in musculoskeletal research as a complementary approach to using standard laboratory rodent models for solving problems in musculoskeletal physiology. This approach may increase our ability to treat musculoskeletal diseases clinically. For example, it has been noted that progress in osteogenesis imperfecta research has been limited by the absence of a naturally occurring animal model. Several examples of naturally occurring animal models are discussed including osteoarthritis and osteosarcoma in dogs, resistance to disuse induced bone and skeletal muscle loss in mammalian hibernators, and bone phenotypic plasticity in fish lacking osteocytes. Many musculoskeletal diseases (e.g., osteoarthritis) occur naturally in companion animals, which may provide clues on etiology and progression of musculoskeletal diseases and accelerate the development of pharmaceutical therapies for humans. Keywords: Animal Models, Comparative Physiology, Companion Animals, Evolutionary Physiology, Musculoskeletal August Krogh: his research and his principle plant, insect, amphibian, bird, mammal) to study problems in physiology. -
Banting and Best: the Extraordinary Discovery of Insulin
106 Rev Port Endocrinol Diabetes Metab. 2017;12(1):106-115 Revista Portuguesa de Endocrinologia, Diabetes e Metabolismo www.spedmjournal.com Artigo de Revisão Banting and Best: The Extraordinary Discovery of Insulin Luís Cardosoa,b, Dírcea Rodriguesa,b, Leonor Gomesa,b, Francisco Carrilhoa a Department of Endocrinology, Diabetes, and Metabolism, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal b Faculty of Medicine of the University of Coimbra, Coimbra, Portugal INFORMAÇÃO SOBRE O ARTIGO ABSTRACT Historial do artigo: Diabetes was a feared disease that most certainly led to death before insulin discovery. During the first Recebido a XX de XXXX de 201X two decades of the 20th century, several researchers tested pancreatic extracts, but most of them caused Aceite a XX de XXXX de 201X Online a 30 de junho de 2017 toxic reactions impeding human use. On May 1921, Banting, a young surgeon, and Best, a master’s student, started testing the hypothesis that, by ligating the pancreatic ducts to induce atrophy of the exocrine pancreas and minimizing the effect of digestive enzymes, it would be possible to isolate the Keywords: internal secretion of the pancreas. The research took place at the Department of Physiology of the Diabetes Mellitus University of Toronto under supervision of the notorious physiologist John MacLeod. Banting and Insulin/history Best felt several difficulties depancreatising dogs and a couple of weeks after the experiments had Pancreatic Extracts/history begun most of the dogs initially allocated to the project had succumbed to perioperative complications. When they had depancreatised dogs available, they moved to the next phase of the project and prepared pancreatic extracts from ligated atrophied pancreas. -
Animal Use in Major Depressive Disorder: a Necessary Evil? Assessing the Past to Improve the Future
UNIVERSIDADE DE LISBOA FACULDADE DE CIÊNCIAS Animal use in Major Depressive Disorder: a necessary evil? Assessing the past to improve the future “Documento Definitivo” Doutoramento em Biologia Especialidade Biotecnologia Maria Constança Dias Pinheiro de Oliveira Carvalho Tese orientada por: Professor Doutor Andrew David Knight Professor Doutor Luís António de Matos Vicente Professor Doutor Tiago André Lamas Oliveira Marques Documento especialmente elaborado para a obtenção do grau de doutor 2020 UNIVERSIDADE DE LISBOA FACULDADE DE CIÊNCIAS Animal use in Major Depressive Disorder: a necessary evil? Assessing the past to improve the future Doutoramento em Biologia Especialidade de Biotecnologia Maria Constança Dias Pinheiro de Oliveira Carvalho Tese orientada por: Professor Doutor Andrew David Knight Professor Doutor Luís António de Matos Vicente Professor Doutor Tiago André Lamas Oliveira Marques Júri: Presidente: ● Doutora Sólveig Thorsteinsdottir, Professora Associada com Agregação da Faculdade de Ciências da Universidade de Lisboa Vogais: ● Doutor Andrew Knight, Professor na Faculty of Health and Wellbeing da University of Winchester (Reino Unido) (Orientador) ● Doutora Paula Maria Marques Leal Sanches Alves, Investigadora Principal do Instituto de Tecnologia Química e Biológica António Xavier (ITQB) da Universidade Nova de Lisboa ● Doutor Rui Filipe Nunes Pais de Oliveira, Professor Catedrático do ISPA - Instituto Universitário de Ciências Psicológicas, Sociais e da Vida ● Doutor Davide Vecchi, Investigador Júnior do Centro de Filosofia das Ciências da Universidade de Lisboa ● Doutor Rui Miguel Borges Sampaio e Rebelo, Professor Auxiliar da Faculdade de Ciências da Universidade de Lisboa Documento especialmente elaborado para a obtenção do grau de doutor AnimalFreeResearch/Switzerland John Hopkins University Center for Alternatives to Animal Testing 2020 I This research was funded by AnimalFreeResearch/Switzerland and, partially, by the John Hopkins University Center for Alternatives to Animal Testing. -
THE ETHICAL DILEMMA of SCIENCE and OTHER WRITINGS the Rockefeller Institute Press
THE ETHICAL DILEMMA OF SCIENCE AND OTHER WRITINGS The Rockefeller Institute Press IN ASSOCIATION WITH OXFORD UNIVERSITY PRESS NEW YORK 1960 @ 1960 BY THE ROCKEFELLER INSTITUTE PRESS ALL RIGHTS RESERVED BY THE ROCKEFELLER INSTITUTE PRESS IN ASSOCIATION WITH OXFORD UNIVERSITY PRESS Library of Congress Catalogue Card Number 60-13207 PRINTED IN THE UNITED STATES OF AMERICA CONTENTS CHAPTER ONE The Ethical Dilemma of Science Living mechanism 5 The present tendencies and the future compass of physiological science 7 Experiments on frogs and men 24 Scepticism and faith 39 Science, national and international, and the basis of co-operation 45 The use and misuse of science in government 57 Science in Parliament 67 The ethical dilemma of science 72 Science and witchcraft, or, the nature of a university 90 CHAPTER TWO Trailing One's Coat Enemies of knowledge 105 The University of London Council for Psychical Investigation 118 "Hypothecate" versus "Assume" 120 Pharmacy and Medicines Bill (House of Commons) 121 The social sciences 12 5 The useful guinea-pig 127 The Pure Politician 129 Mugwumps 131 The Communists' new weapon- germ warfare 132 Independence in publication 135 ~ CONTENTS CHAPTER THREE About People Bertram Hopkinson 1 39 Hartley Lupton 142 Willem Einthoven 144 The Donnan-Hill Effect (The Mystery of Life) 148 F. W. Lamb 156 Another Englishman's "Thank you" 159 Ivan P. Pavlov 160 E. D. Adrian in the Chair of Physiology at Cambridge 165 Louis Lapicque 168 E. J. Allen 171 William Hartree 173 R. H. Fowler 179 Joseph Barcroft 180 Sir Henry Dale, the Chairman of the Science Committee of the British Council 184 August Krogh 187 Otto Meyerhof 192 Hans Sloane 195 On A. -
Accountability
ACCOUNTABILITY animal experiments & freedom of information The assessment of projects under the Animals (Scientific Procedures) Act 1986 The licensing process The Animal Procedures Committee The application of Nolan principles ACCOUNTABILITY animal experiments & freedom of information - a parliamentary briefing CONTENTS 1. Introduction 1 2. Background 2 3. Secrecy vs Transparency 5 4. Put it to the test 9 5. The Animal Procedures Committee 13 6. Reform of the APC 16 7. Local Ethics Committees 21 8. Conclusions 25 Appendix: Profile of current members of the APC 261 Goldhawk Road, London W12 9PE. Tel. 0181 846 9777 Fax. 0181 846 9712 e-mail: [email protected] Web: http://www.cygnet.co.uk/navs ©NAVS 1997 ACCOUNTABILITY 1. Introduction There is undoubtedly considerable public disquiet that cruel, unnecessary or repetitive research continues on animals in British laboratories. Bland government assurances that our legislation is the ‘best in the world’ do not convince a public now familiar with video and photographic evidence of the reality of animal experimentation. The secrecy with which the law is administered only hardens the conviction that there is something to hide. Well documented evidence from the NAVS and others has shown that government guidelines and the ‘Code of Practice for the Housing and Care of Laboratory Animals’ are not diligently enforced and that the Home Office leans towards protection of vivisection industry interests rather than towards serving the public will. It has taken undercover investigations to expose serious abuses within the system. In March 1997 a Channel 4 investigation led to the threat of the revocation of the Certificate of Designation for Huntingdon Life Sciences and the prosecution of former staff members. -
Perspectives
PERSPECTIVES several organizations that were set up to SCIENCE AND SOCIETY continue the campaign. In both the United States and Europe, the debate about animal experimentation waned Animal experimentation: with the advent of the First World War, only to re-emerge during the 1970s, when anti- the continuing debate vivisection and animal-welfare organizations joined forces to campaign for new legislation to regulate animal research and testing. In the Mark Matfield United States, the public debate re-emerged in a more dramatic fashion in 1980, when an The use of animals in research and there was considerable protest from some activist infiltrated the laboratory of Dr Edward development has remained a subject of members of the audience and that, after one Taub of the Institute of Behavioural Research public debate for over a century. Although animal had been injected, an eminent med- at Silver Spring, Maryland (BOX 1). This attack there is good evidence from opinion surveys ical figure summoned the magistrates to on Taub’s research was organized by a tiny that the public accepts the use of animals in prevent the demonstration from continuing. animal-rights group called People for the research, they are poorly informed about the The Royal Society for the Prevention of Ethical Treatment of Animals (PETA), which way in which it is regulated, and are Cruelty to Animals (RSPCA) brought a pros- has since grown to dominate the campaign in increasingly concerned about laboratory- ecution for cruelty, and several of the doctors the United States. animal welfare. This article will review how present at the demonstration gave evidence public concerns about animal against Magnan, who returned to France to The anatomy of the campaign experimentation developed, the recent avoid answering the charges.