DOCSLIB.ORG

(12) United States Patent (10) Patent No.: US 7.534455 B2 Cheng Et Al

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
(12) United States Patent (10) Patent No.: US 7.534455 B2 Cheng Et Al USOO7534455B2 (12) United States Patent (10) Patent No.: US 7.534455 B2 Cheng et al. (45) Date of Patent: *May 19, 2009 (54) HERBAL COMPOSITION PHY906 AND ITS (56) References Cited USE IN CHEMOTHERAPY U.S. PATENT DOCUMENTS (75) Inventors: Yung-Chi Cheng, Woodbridge, CT 4,618,495 A * 10/1986 Okuda et al. ................ 424,728 (US): Shwu-Huey Liu, Madison, CT 5,595,756 A * 1/1997 Bally et al. ................. 424/450 (US) 5,665,393 A * 9/1997 Chen et al. ........ ... 424/489 6,048,847 A * 4/2000 Ramadoss et al. ........... 514,169 (73) Assignee: Yale University, New Haven, CT (US) 6,630,176 B2 * 10/2003 Li et al. ...................... 424,728 (*) Notice: Subject to any disclaimer, the term of this 2003/0180395 A1 9, 2003 Bueter ........................ 424,725 patent is extended or adjusted under 35 U.S.C. 154(b) by 376 days. OTHER PUBLICATIONS This patent is Subject to a terminal dis Suzuki et al. Supressor Macrophages: A Role on the Growth of claimer. Transplanted Tumors and Regulation by an Extract of Licorice, Glycyrrhizin; Oncologia (Tokyo), 1987, 20(5), pp. 124-133; one (21) Appl. No.: 11/100,433 page Abstract from STN database only provided.* Raskin et al. Can an Apple a Day Keep the Doctor Away? Current (22) Filed: Apr. 7, 2005 Pharmaceutical Design, 2004, 10, pp. 3419-3429.* H.B. MacPhillamy: Plant Science Bulletin, Apr. 1963, vol. 9, Issue 2. (65) Prior Publication Data pp. 1-15.* US 2005/O196473 A1 Sep. 8, 2005 * cited by examiner Related U.S. Application Data Primary Examiner Patricia Leith (63) Continuation-in-part of application No. 10/220,876, (74) Attorney, Agent, or Firm—Cooley Godward Kronish filed as application No. PCT/US01/07353 on Mar. 8, LLP 2001, now Pat. No. 7,025,993, which is a continuation in-part of application No. 09/522,055, filed on Mar. 9, (57) ABSTRACT 2000, now abandoned. (60) Provisional application No. 60/625,943, filed on Nov. This invention provides herbal compositions useful for 9, 2004. increasing the therapeutic index of drugs, including those used in the treatment of disease, especially viral infections (51) Int. C. and neoplasms of cancer. This invention provides methods A6 IK 36/484 (2006.01) useful for improving the quality of life of an individual under A6 IK 36/725 (2006.01) going chemotherapy. Furthermore, this invention improves A6 IK 36/539 (2006.01) the treatment of disease by increasing the therapeutic index of A6 IK 36/65 (2006.01) chemotherapy drugs by administering the herbal composition (52) U.S. Cl. ...................................................... 424/725 PHY906 to a person undergoing such chemotherapy. (58) Field of Classification Search ....................... None See application file for complete search history. 4 Claims, 38 Drawing Sheets 150 100 50 -o-CONTROL (VEHICLE) -ve PHY 906 -o-FU/LV - y PHY 906 - FU/LV O 2 3 4 5 6 7 8 9 O DAYS AFTER CPT-11 TREATMENT U.S. Patent May 19, 2009 Sheet 1 of 38 US 7.534455 B2 ??ºldOON 6×6u)000||NEWIVEH1(£AWG)(8AWG) ON |NHWIWEBH1 (£AWG) 0 0/ HSM MOOTWILINO 39WINOld U.S. Patent May 19, 2009 Sheet 3 of 38 US 7,534.455 B2 FIG, 3 1800 500 -o-CONTROL (VEHICLE) -v-PHY 906 -- CP-1 -O-PHY 906 CPT-11 1200 P 900 O 2 3 4. 5 6 7 8 9 DAYS AFTER CPT-11 TREATMENT t-TEST CPT-11 CONTROL h P YY AT GENESPHY 906 CPT-11 p.6 PHY906 osso- 0.0027 0.0001 CPT-11 0.0027 - 0.0007 CPT-1 0.0001 0.000 0.0007 WITH PHY 906 U.S. Patent May 19, 2009 Sheet 4 of 38 US 7.534455 B2 FIG. 4 200 WBC 60 120 NNNNN SNNNN 60 40 O SÈN 200 60 RBC 120 8 TOHINOOHOE??)WINEOHEId 40 (No. 160 PLT 120 8 `N9 RN RNNs) DAYS AFTER CPT-TREATMENT CONTROL (VEHICLE) PHY 906 ZCPT-1 OPHY 906 CPT-11 U.S. Patent May 19, 2009 Sheet 5 Of 38 US 7.534455 B2 150 FIG. 5 100 50 -o-CONTROL (VEHICLE) -Ve-PHY 906 -o-FU/LV -v-PHY 906 - FU/LV 0 1 2 3 4 5 6 7 8 9 O DAYS AFTER CPT-11 TREATMENT U.S. Patent May 19, 2009 Sheet 6 of 38 US 7.534455 B2 FIG, 6 800 -o-CONTROL (VEHICLE) -v-PHY 906 -o-FU/LV 600 yePHY 906 - FU/LV A 7 w 400 200 1 2 3 4 5 6 7 8 9 DAYS AFTER CPT-11 TREATMENT U.S. Patent May 19, 2009 Sheet 7 Of 38 US 7.534455 B2 250 FIG, 7 200 150 100 50 O ÈN), HTT 250 §Nº. 200O R 150 TOHINOOJOESOVINE|0}}3d 1 OO 50 H)| O HOE H()| |NCN)| §), ?!), 250 200 50 100 50 O DAYS AFTER CPT-11 TREATMENTRNNs) CONTROL (VEHICLE) PHY 906 OPHY 906 - FU/LV U.S. Patent May 19, 2009 Sheet 8 of 38 US 7.534455 B2 FG, 8 H is 3000 -o-CONTROL (VEHICLE) 2500 -v- PHY 906 O -0- CPT-11 - FU/LV 22 2000 -O-PHY 906+ CP-11/FU/LV - s 1500 2 f 1000 2. CDC 21O Hale1. 500 a. 51 2. f O us-X he 0. 2 4. 6 8 10 12 14 DAYS AFTER CPT-11 TREATMENT U.S. Patent May 19, 2009 Sheet 9 of 38 US 7,534.455 B2 3000 CD L is 2500 -o-CONTROL (VEHICLE) 5 -V-PHY 906 S2000 -0-CPT-11 - FU/LV C -O-PHY 906 CPT-11/FU/LV s 1500 5 too V 9. 75 500 y L2 OQx: is: 0 E4XX DAYS AFTER CPT-11 TREATMENT U.S. Patent May 19, 2009 Sheet 10 of 38 US 7,534.455 B2 FG, 10 110 E > Y.Ni h 292Hi C o Y sH 4. ( R Z O s -o-CONTROL (VEHICLE) 1. -V-PHY 906 2 -0- CPT-11/FU/LV -O-PHY 906 CPT-11AFU/LV 80 O 2 4 6 8 10 12 DAYS AFTER CPT-11 TREATMENT U.S. Patent May 19, 2009 Sheet 11 of 38 US 7.534455 B2 FIG 11 S'EE -o-CONTROL (VEHICLE) st 700 -v- PHY 906 5 -0- 6PT-11 600E -- CPT-11+ PHY 906 l % 5 C X7 g 500400 ;A. 5300 O 3. 200 Y 5.E-2y 100e2 0 a 0 1 2 3 4 5 6 7 8 9 10 11121314 DAYS AFTER CPT-11 TREATMENT t-tist (PVALUE) CONTROL ATDAY 14 (VEHICLE) PHY 906 CPT-11 PHY 906 U.S. Patent May 19, 2009 Sheet 12 of 38 US 7,534.455 B2 10 FIG, 12 100 a 90 80 -o-CONTROL (VEHICLE) -v-PHY 906 -0- CPT-11 -O-CPT-11+ PHY 906 70 0 1 2 3 4 5 6 7 8 9 101112 1314 DAYS AFTER CPT-11 TREATMENT U.S. Patent May 19, 2009 Sheet 13 of 38 US 7.534455 B2 Hot - HQ - H- N M N H-SS H-H-(D- to bi-h-i- to E ----toW O a E Y. V H-Q- KH-t- - rt H&- - - - - 3. y V ?a He-H+ Hv Y O O S S o s () V GN few Jouni eugo effeueled U.S. Patent May 19, 2009 Sheet 14 of 38 US 7.534455 B2 ON-g?uðurgeºuL 000), 009 uffleMoun Ieugo effieueoled U.S. Patent May 19, 2009 Sheet 15 of 38 US 7.534455 B2 HQ - H Queu?eeuLON,c,… 002), 000), 008 009 ufeWJouneyulo effeueoled U.S. Patent May 19, 2009 Sheet 16 of 38 US 7.534455 B2 HO- N N N s H-S- te ' T 3 H-e- to s C s 5As O A. s g y o C. o r (e) s O U) E 9.G S SP>e H-6- aE O E y in 5 H. C. D. GN 5> 2O St O O O O C O O tS queS S. s ufew Jouni eugo effeueoled U.S. Patent May 19, 2009 Sheet 17 Of 38 US 7.534455 B2 819Gy£.Z ?uðu?eau,le???u?J???esÁed 00:21, 000), 008 009 007 00:2 ufem Oun Ieu Jo effeueoue U.S. Patent May 19, 2009 Sheet 18 of 38 US 7,534.455 B2 FG, 18 300 --CPT-11/FU/LV -O-PHY-906-6 0 so --too."" ceterre 20 B --CPT-1/FU/LV -O-PHY-906-6 s 2. 3 10 Z 92. 0 re- rto 12o so to go 2000 C --CPT-FU/LV d -o-PHY906-6-CPT-11/FU/LV D D 1000 C O - D . o, to TIME AFTER CPT-11/FUADMINISTRATION U.S. Patent May 19, 2009 Sheet 19 of 38 US 7,534.455 B2 FIG. 19 --CPT-1/FU/LV -o- PHY-906-6-CPT-11/FU/LV 0 600 1200 1800 2400 3000 (min) B --CPT-1/FU/LV -o- PHY-906-6-CPT-1/FU/LV O 600 1200 800 2400 3000 (min) C --CPT-1/FU/LV -O-PHY-906-6-CPT-111FU/LV Y O O 600 1200 1800 2400 3000 TIME AFTER Fuct ADMINISTRATION min) U.S. Patent May 19, 2009 Sheet 20 of 38 US 7.534455 B2 FIG. 20 --CPT-1/FU/LV -O-PHY-906-6+ CPT-11/FU/LV O 600 1200 800 2400 3000 (min) --CPT-1/FU/LV -O-PHY-906-6 CP-1/FU/LV O 600 1200 1800 2400 3000 TIME AFTER Fuca ADMINISTRATION U.S. Patent May 19, 2009 Sheet 21 of 38 US 7.534455 B2 600 400 ir control (vehicle de PHYoscomys -- Gemcitabine 150 mg/kg 200 - PHY-08500 mg/kg+ Gemcitabine songkg 1 2 3 4 5 6 7 8 9 10 11 12 Days After initial Treatment PHYgos N n Geractabine ? ? FIG.
Load more

Recommended publications
  • Cally Plant List a ACIPHYLLA Horrida
    Cally Plant List A ACIPHYLLA horrida ACONITUM albo-violaceum albiflorum ABELIOPHYLLUM distichum ACONITUM cultivar ABUTILON vitifolium ‘Album’ ACONITUM pubiceps ‘Blue Form’ ACAENA magellanica ACONITUM pubiceps ‘White Form’ ACAENA species ACONITUM ‘Spark’s Variety’ ACAENA microphylla ‘Kupferteppich’ ACONITUM cammarum ‘Bicolor’ ACANTHUS mollis Latifolius ACONITUM cammarum ‘Franz Marc’ ACANTHUS spinosus Spinosissimus ACONITUM lycoctonum vulparia ACANTHUS ‘Summer Beauty’ ACONITUM variegatum ACANTHUS dioscoridis perringii ACONITUM alboviolaceum ACANTHUS dioscoridis ACONITUM lycoctonum neapolitanum ACANTHUS spinosus ACONITUM paniculatum ACANTHUS hungaricus ACONITUM species ex. China (Ron 291) ACANTHUS mollis ‘Long Spike’ ACONITUM japonicum ACANTHUS mollis free-flowering ACONITUM species Ex. Japan ACANTHUS mollis ‘Turkish Form’ ACONITUM episcopale ACANTHUS mollis ‘Hollard’s Gold’ ACONITUM ex. Russia ACANTHUS syriacus ACONITUM carmichaelii ‘Spätlese’ ACER japonicum ‘Aconitifolium’ ACONITUM yezoense ACER palmatum ‘Filigree’ ACONITUM carmichaelii ‘Barker’s Variety’ ACHILLEA grandifolia ACONITUM ‘Newry Blue’ ACHILLEA ptarmica ‘Perry’s White’ ACONITUM napellus ‘Bergfürst’ ACHILLEA clypeolata ACONITUM unciniatum ACIPHYLLA monroi ACONITUM napellus ‘Blue Valley’ ACIPHYLLA squarrosa ACONITUM lycoctonum ‘Russian Yellow’ ACIPHYLLA subflabellata ACONITUM japonicum subcuneatum ACONITUM meta-japonicum ADENOPHORA aurita ACONITUM napellus ‘Carneum’ ADIANTUM aleuticum ‘Japonicum’ ACONITUM arcuatum B&SWJ 774 ADIANTUM aleuticum ‘Miss Sharples’ ACORUS calamus ‘Argenteostriatus’
    [Show full text]
  • AGS Seed List No 69 2020
    Seed list No 69 2020-21 Garden Collected Seed 1001 Abelia floribunda 1057 Agrostemma githago 1002 Abies koreana 1058 Albuca canadensis (L.
    [Show full text]
  • 2020 Spring Distribution
    2020 Spring Distribution The staff, Board, and volunteers of the Rhododendron Species Botanical Garden (RSBG) are pleased to present our latest selection of Rhododendron species and companion plants. We provide the finest and largest selection of documented and verified as true to name clones of Rhododendron species in North America. We also offer a large selection of species grown from seed, the majority of these from wild populations. Seedlings provide an exciting opportunity to acquire taxa new to cultivation. They also provide the collector with the opportunity to grow those desirable species not readily produced through asexual propagation. Our ever-expanding collection of non-rhododendrons or “companion plants” provides the opportunity to acquire an outstanding range of rare and hard to find treasures selected from around the world. Your purchases directly fund the mission of the RSF. In addition to your own selections, don’t forget your neighbors, relatives, and friends - our plants make great and unusual gifts. RSF plants also make great door prizes and auction items at American Rhododendron Society and other garden club meetings. We hope you enjoy the catalog and are happy with the plants you receive. Thank you for your support! Steve Hootman Executive Director & Curator HOW TO ORDER PLANTS: Mail Orders: Please mail your order to RSF, P. O. Box 3798, Federal Way, Washington 98063-3798 USA Fax Orders: You may also fax your order to 253-838-4686 E-mail Orders: You may submit your order via [email protected] but please do not e-mail your credit card information. Call 253-838-4646 to submit your credit card information.
    [Show full text]
  • Climatic Refugia and Geographical Isolation Contribute to the Speciation and Genetic Divergence in Himalayan-Hengduan Tree Peoni
    ORIGINAL RESEARCH published: 27 January 2021 doi: 10.3389/fgene.2020.595334 Climatic Refugia and Geographical Isolation Contribute to the Speciation and Genetic Divergence in Himalayan-Hengduan Tree Peonies (Paeonia delavayi and Paeonia ludlowii) Yu-Juan Zhao 1,2, Gen-Shen Yin 3, Yue-Zhi Pan 2, Bo Tian 4 and Xun Gong 1,2* 1 Key Laboratory for Plant Diversity and Biogeography of East Asia, Kunming Institute of Botany, Chinese Academy of Sciences (CAS), Kunming, China, 2 Key Laboratory of Economic Plants and Biotechnology, Kunming Institute of Botany, Chinese Academy of Sciences (CAS), Kunming, China, 3 College of Agriculture and Life Sciences, Kunming University, Chinese Academy of Sciences (CAS), Kunming, China, 4 Key Laboratory of Tropical Plant Resource and Sustainable Use, Xishuangbanna Tropical Botanical Garden, Chinese Academy of Sciences, Mengla, China Himalaya and Hengduan Mountains (HHM) is a biodiversity hotspot, and very rich in endemic species. Previous phylogeographical studies proposed different hypotheses Edited by: (vicariance and climate-driven speciation) in explaining diversification and the observed Genlou Sun, pattern of extant biodiversity, but it is likely that taxa are forming in this area in Saint Mary’s University, Canada species-specific ways. Here, we reexplored the phylogenetic relationship and tested Reviewed by: Guifang Zhao, the corresponding hypotheses within Paeonia subsect. Delavayanae composed of Northwest University, China one widespread species (Paeonia delavayi) and the other geographically confined Yong Li, species (Paeonia ludlowii). We gathered genetic variation data at three chloroplast Henan Agricultural University, China DNA fragments and one nuclear gene from 335 individuals of 34 populations *Correspondence: Xun Gong sampled from HHM.
    [Show full text]
  • Pollen Morphology of Herbaceous Peonies with Different Ploidy Levels
    J. AMER.SOC.HORT.SCI. 141(3):275–284. 2016. Pollen Morphology of Herbaceous Peonies with Different Ploidy Levels Lihong Hao and Hui Ma College of Landscape Architecture, Beijing Forestry University, Beijing, 100083, P.R. China Jaime A. Teixeira da Silva P.O. Box 7, Miki-cho post office, Ikenobe 3011-2, Kagawa-ken, 761-0799, Japan XiaoNan Yu1 College of Landscape Architecture, Beijing Forestry University, Beijing, 100083, P.R. China; and Beijing Key Laboratory of Ornamental Plants Germplasm Innovation and Molecular Breeding, National Engineering Research Center for Floriculture, Beijing, 100083, P.R. China ADDITIONAL INDEX WORDS. Paeonia ABSTRACT. The pollen morphology of 26 cultivars of herbaceous peony (Paeonia L.) was examined by scanning electron microscopy (SEM). Pollen grains of the cultivars were mostly subprolate to perprolate, tricolporate, or ellipsoidal in equatorial view, but rounded-trifid in polar view. The poles of pollen grains were mainly flat when viewed in cross-section and only a few appeared to have a circular or arc shape. In addition, the surface of the pollen grains was psilate, and the muri were partly or fully protuberant with a reticulate surface sculpture. However, the shapes and sizes of pollen grains as well as surface ornamentation varied significantly among cultivars with different chromosome numbers. The pollen grains from diploid cultivars were regular and full, and the reticulation holes were evenly distributed, while most of the pollen grains from triploid cultivars were empty flat shells with some heteromorphic pollen whose surface ornamentation was mostly rugulate-reticulate exine. The pollen grains from tetraploid cultivars were the largest although pollen morphology and surface ornamentation differed between Athena and Cream Delight.
    [Show full text]
  • INDEX SEMINUM 2018 Gothenburg Botanical Garden, Sweden
    INDEX SEMINUM GOTHENBURG BOTANICAL GARDEN SWEDEN 2018 Eryngium maritimum L. INDEX SEMINUM 2018 Gothenburg Botanical Garden, Sweden Seeds from the Index Seminum are not for sale, but are available on an exchange basis exclusively for scientific, educational and nature conservation purposes. Orders can be placed until March 31, 2018. We prefer orders to be posted online, but the desiderata found in the end of this catalogue can also be used and sent by e-mail or mail (reaching us by March 31 at the latest). The orders will be dispatched according to the availability of seeds. Index Seminum online: gotbot.indexseminum.org Contact: [email protected] The seed catalogue • The family classification follows APGIII. • All seeds were collected in 2017. • Indicated provenance is for seeds. • Index of collectors’ initials can be found in the end of the catalogue. The garden • Latitude/longitude: 57.6805/11.9549 • Altitude: 27–120 m a.s.l. • Mean temperature (past 10 years): 9.0 °C (0.6 °C for February, 18.4 °C for July) • Mean annual precipitation (past 10 years): 948 mm Amaryllidaceae 1 Allium acuminatum Coll.no: J.NIL 16-2, USA: Colorado, Elk River Road, Steamboat, Routt Count!. "rov: #arden - $ild ori%in. 2 Allium anceps USA: Nevada. "rov: #arden - $ild ori%in. 3 Allium bisceptrum USA: Nevada, L!on Co. S of Como, 1'() m. "rov: #arden - $ild origin. 4 Allium caesium U*+: S. ,lope of . ramin /t. range, near v. Re0ok,ai on Rd. .okand-1a,23kent, 1()) m. "rov: #arden - $ild ori%in. 5 Allium caesium 'Wijnrode Selektion' "rov: #arden.
    [Show full text]
  • Polly Hill Arboretum Plant Collection Inventory March 14, 2011 *See
    Polly Hill Arboretum Plant Collection Inventory March 14, 2011 Accession # Name COMMON_NAME Received As Location* Source 2006-21*C Abies concolor White Fir Plant LMB WEST Fragosa Landscape 93-017*A Abies concolor White Fir Seedling ARB-CTR Wavecrest Nursery 93-017*C Abies concolor White Fir Seedling WFW,N1/2 Wavecrest Nursery 2003-135*A Abies fargesii Farges Fir Plant N Morris Arboretum 92-023-02*B Abies firma Japanese Fir Seed CR5 American Conifer Soc. 82-097*A Abies holophylla Manchurian Fir Seedling NORTHFLDW Morris Arboretum 73-095*A Abies koreana Korean Fir Plant CR4 US Dept. of Agriculture 73-095*B Abies koreana Korean Fir Plant ARB-W US Dept. of Agriculture 97-020*A Abies koreana Korean Fir Rooted Cutting CR2 Jane Platt 2004-289*A Abies koreana 'Silberlocke' Korean Fir Plant CR1 Maggie Sibert 59-040-01*A Abies lasiocarpa 'Martha's Vineyard' Arizona Fir Seed ARB-E Longwood Gardens 59-040-01*B Abies lasiocarpa 'Martha's Vineyard' Arizona Fir Seed WFN,S.SIDE Longwood Gardens 64-024*E Abies lasiocarpa var. arizonica Subalpine Fir Seedling NORTHFLDE C. E. Heit 2006-275*A Abies mariesii Maries Fir Seedling LNNE6 Morris Arboretum 2004-226*A Abies nephrolepis Khingan Fir Plant CR4 Morris Arboretum 2009-34*B Abies nordmanniana Nordmann Fir Plant LNNE8 Morris Arboretum 62-019*A Abies nordmanniana Nordmann Fir Graft CR3 Hess Nursery 62-019*B Abies nordmanniana Nordmann Fir Graft ARB-CTR Hess Nursery 62-019*C Abies nordmanniana Nordmann Fir Graft CR3 Hess Nursery 62-028*A Abies nordmanniana Nordmann Fir Plant ARB-W Critchfield Tree Fm 95-029*A Abies nordmanniana Nordmann Fir Seedling NORTHFLDN Polly Hill Arboretum 86-046*A Abies nordmanniana ssp.
    [Show full text]
  • NEW PLANTINGS in the Arboretum T E X T B Y R a Y L a R S O N | P H O T O S B Y N I a Ll D U N N E
    NEW PLANTINGS in the Arboretum T EX T BY R AY L A R SON | P HO T OS BY N IA ll D UNNE Thinning the canopy in Rhododendron Glen is helping historic collections thrive and new understory plantings to become established. THE YEAR or most folks, this past year has presented challenges like no other in IN living memory. Not surprisingly, the resilience of the natural world and REVIEW the serenity of gardens have provided us with welcome solace. It has Fbeen gratifying to see so many visitors to the Arboretum throughout the pan- demic, experiencing what most of us have always valued about this special place: the beautiful landscapes, and the calming influence of seasonal change and the rhythms of nature. The Arboretum has not been immune from the difficulties caused by the pandemic. Reductions in staff hours, especially during the early days of the shutdown, caused the delay and rethinking of many planting and maintenance projects. The restriction of volunteer activities also has been acutely felt. Even in the best of times, our limited staff rely on our tremendous volunteers to help keep the collections and planting beds looking good. The need for social distancing and other new safety measures has led to changes and adaptations in nearly all aspects of our work. Winter 2021 v 3 However, nature doesn’t wait, and plants remove the invasives. Mature examples of and weeds continue to grow. Despite all the mountain hemlock (Tsuga mertensiana) and challenges, we’ve tried to maintain forward magnolia species were suddenly visible and momentum and keep things looking as present- enjoying the added light.
    [Show full text]
  • 6 Nbgcollections P to Q. 6 Feb 2018
    Index to the Living collections at the National Botanic Gardens, Glasnevin (P to Q) Pachycereus marginatus (2010.0076 - CC, CC), Pachyphragma macrophyllum (2005.0083 - Fam2), Pachypodium lamerei (2007.0584 - CC), Pachysandra terminalis (XX.013934 - CT-north; XX.013935 - CT-north; 1998.0887 - SL), Paederia scandens (XX.005907 - VB-w), Paederia scandens var. tomentosa (2002.3931 - Fam3), Paeonia 'Akashigata' (2004.0191 - VB-f), Paeonia 'Alice Harding' (2012.1939 - VB-f), Paeonia 'Anne Rosse' (1970.0252 - VB-f), Paeonia anomala (XX.006289 - VB-h; XX.006318 - VB-h), Paeonia arientina (XX.006295 - VB-h, VB-h, VB-h), Paeonia 'Artemis' (1972.1569 - VB-f, VB-f), Paeonia bakeri (XX.006316 - VB-h), Paeonia 'Banquet' (2008.2156 - VB-f), Paeonia 'Beatrice Kelway' (XX.006379 - VB-e), Paeonia cambessedesii (XX.005719 - RRA), Paeonia 'Cardinal Vaughan' (2004.0193 - VB-f), Paeonia 'Chinese Dragon' (2008.2157 - VB-f), Paeonia corallina (1975.0513 - Fam1), Paeonia 'Darius' (XX.006371 - VB-e), Paeonia 'Defender' (XX.006374 - VB-e), Paeonia delavayi (XX.000404 - CH; 1967.0387 - VB-f; XX.006352 - VB-f), Paeonia 'Dreadnought' (XX.006366 - VB-e), Paeonia 'Duchess of Marlborough' (2004.0195 - VB-f), Paeonia emodi (XX.006296 - VB-e; 2006.3516 - VB-h; XX.006296 - VB-h, VB-h; XX.006336 - VB-h, VB-h), Paeonia 'Fen Dan Bai' (2004.0196 - VB-f), Paeonia Gansu Group 'Bing Xin Ye Guang Bei' (2008.2176 - VB-f), Paeonia Gansu Group 'Guang Hui Li Cheng' (2008.2177 - VB-f), Paeonia Gansu Group 'Hei Feng Die' (2008.2178 - VB-f), Paeonia Gansu Group 'Mo Hai Yin Bo' (2008.2179
    [Show full text]
  • Paeonia (Pivoňka)
    Paeonia (Pivoňka) čeleď: Paeoniaceae Roste v podobě trvalky nebo keře. Pod zemí vytváří hlízovité kořeny. Větve jsou vzpřímené. Listy jsou velké, střídavé, peřeně až složeně členěné. Kvete samostatnými oboupohlavnými květy, mají 5 kališních lístků, 4 - 13 korunních mnohem větší velikosti v barvě červené, růžové, bílé nebo nažloutlé, na vrcholu vykousávané, mají až 230 tyčinek a 1 - 8 pestíků. Plodem je dřevnatý měchýřek obsahující kulaté až eliptické lesklé semeno o velikosti až 1cm. Nejznámějším druhem u nás je P. officinalis . Velkou sbírku pivoňek naleznete v Liberecké botanické zahradě, ale největší jsou v Průhonicích (dřevité i bylinné) a Tróji (bylinné). Existují např. tyto vnitrodruhové taxony: - 'Adriane' - květy 1/2plné, růžovooranžové - 'Alexander Fleming' - 'Alhambra' - květy 1/2plné, žluté - 'Anglet' - květy jednoduché, žluté a růžové - 'Anna Marie' - výška do 80cm; květy jednoduché, velké, korunní lístky růžovofialové s tmavšími odlesky - 'Artemis' - květy jednoduché, žluté - 'Aurora' - květy 1/2plné, žluté - 'Balliol' - 'Bartzella' - květy plnokvěté, žluté - 'Border Charm' - květy 1/2květé, žluté - 'Bowl of Beauty' - 'Brocade' - květy jednoduché, žluté - 'Bu-Te' - 'Bunker Hill' - 'Canary' - květy jednoduché, žluté - 'Cora Louise' - květy 1/2plné, bílé a růžovočervené - 'Coral Charm' - 'Coronal' - květy 1/2plné, bílé a růžové - 'Corsair' - květy jednoduché, červené - 'Court Jester' - květy jednoduché, žluté - 'Dare Devil' - květy jednoduché, červené - 'Doreen' - 'Edulis Superba' - 'Etienne Mechin' - 'Fancy Nancy' - 'Felix
    [Show full text]
  • The Peony Group
    Officers of the Peony Group Chairperson Kath Carey The Peony Group St Annes Windmill Lane of the Hardy Plant Society Appleton Warrington LU7 9NL e-mail [email protected] Group Secretary Mrs Gail Harland Newsletter Spring 2011 The Owl House Coddenham Green Suffolk IP6 9UN e-mail [email protected] Treasurer Mr John Richey 55 Franklin Court Brook Road Wormley, Godalming Surrey GU8 5US e-mail [email protected] Newsletter editor John Hudson Deene Cottage Back Lane, East Langton Market Harborough Leicestershire LE16 7TB e-mail [email protected] DTP and newsletter distribution is by Irene Tibbenham, The Barn, Clay Street, Thornham Magna, Suffolk, IP23 8HE e-mail: [email protected] Seed distribution is by Judy Templar, 117 Wood Road, King's Cliffe, Northants. PE8 6XR, e-mail: [email protected] Other Committee Members are Peter Johnson (membership secretary) Membership of the Peony Group is available to all members of the Hardy Plant Society. If you are interested in joining, please contact the Secretary at the above address Copy deadlines are 31st March for the Spring Newsletter, and 30th September for the Autumn Newsletter. 16 Editorial John Hudson please contact me; details are on the back page. Thank you to those who put their HPS numbers on the subscription renewal form; our records are near to being com- Some of you will know that the late Jim Archibald, besides being the coun- plete from your efforts. try’s leading supplier of wild collected seeds and an authority on alpines, he It’s a slow cold year so far, with almost everything a month past due.
    [Show full text]
  • Comparative and Phylogenetic Analyses of the Chloroplast Genomes of Species of Paeoniaceae
    www.nature.com/scientificreports OPEN Comparative and phylogenetic analyses of the chloroplast genomes of species of Paeoniaceae Liwei Wu1,2, Liping Nie1,2, Qing Wang1,2, Zhichao Xu1,2, Yu Wang1, Chunnian He1, Jingyuan Song1,2 & Hui Yao1,2* Plants belonging to family Paeoniaceae are not only economically important ornamental plants but also medicinal plants used as an important source of traditional Chinese medicine. Owing to the complex network evolution and polyploidy evolution of this family, its systematics and taxonomy are controversial and require a detailed investigation. In this study, three complete chloroplast genomes of sect. Paeonia, one of the sections of Paeonia, were sequenced and then analysed together with 16 other published chloroplast genomes of Paeoniaceae species. The total lengths of the chloroplast genomes of these species were 152,153–154,405 bp. A total of 82–87 protein-coding genes, 31–40 tRNA genes and 8 rRNA genes were annotated. Bioinformatics analysis revealed 61–74 simple sequence repeats (SSRs) in the chloroplast genomes, most of which have A/T base preference. Codon usage analysis showed that A/U-ending codons were more positive than C/G-ending codons, and a slight bias in codon usage was observed in these species. A comparative analysis of these 19 species of Paeoniaceae was then conducted. Fourteen highly variable regions were selected for species relationship study. Phylogenetic analysis revealed that the species of sect. Paeonia gathered in one branch and then divided into diferent small branches. P. lactifora, P. anomala, P. anomala subsp. veitchii and P. mairei clustered together. P. intermedia was related to P.
    [Show full text]