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Mir-125 in Normal and Malignant Hematopoiesis
Leukemia (2012) 26, 2011–2018 & 2012 Macmillan Publishers Limited All rights reserved 0887-6924/12 www.nature.com/leu SPOTLIGHT REVIEW MiR-125 in normal and malignant hematopoiesis L Shaham1,2, V Binder3,4,NGefen1,5, A Borkhardt3 and S Izraeli1,5 MiR-125 is a highly conserved microRNA throughout many different species from nematode to humans. In humans, there are three homologs (hsa-miR-125b-1, hsa-miR-125b-2 and hsa-miR-125a). Here we review a recent research on the role of miR-125 in normal and malignant hematopoietic cells. Its high expression in hematopoietic stem cells (HSCs) enhances self-renewal and survival. Its expression in specific subtypes of myeloid and lymphoid leukemias provides resistance to apoptosis and blocks further differentiation. A direct oncogenic role in the hematopoietic system has recently been demonstrated by several mouse models. Targets of miR-125b include key proteins regulating apoptosis, innate immunity, inflammation and hematopoietic differentiation. Leukemia (2012) 26, 2011–2018; doi:10.1038/leu.2012.90 Keywords: microRNA; hematopoiesis; hematological malignancies; acute myeloid leukemia; acute lymphoblastic leukemia MicroRNAs (miRNAs) are 21–23-nucleotide non-coding RNAs that nucleotides with the seed region of miR-125b (ebv-miR-BART21-5p, have crucial roles in fundamental biological processes by ebv-miR-BART8 and rlcv-miR-rL1-25). In humans, as in most of the regulating the levels of multiple proteins. They are transcribed genomes, there are two paralogs (hsa-miR-125b-1 on chromosome as primary miRNAs and processed in the nucleus by the RNase III 11 and hsa-miR-125b-2 on chromosome 21), coding for the same endonuclease DROSHA to liberate 70-nucleotide stem loops, the mature sequence. -
Exploration of the Moon
Exploration of the Moon The physical exploration of the Moon began when Luna 2, a space probe launched by the Soviet Union, made an impact on the surface of the Moon on September 14, 1959. Prior to that the only available means of exploration had been observation from Earth. The invention of the optical telescope brought about the first leap in the quality of lunar observations. Galileo Galilei is generally credited as the first person to use a telescope for astronomical purposes; having made his own telescope in 1609, the mountains and craters on the lunar surface were among his first observations using it. NASA's Apollo program was the first, and to date only, mission to successfully land humans on the Moon, which it did six times. The first landing took place in 1969, when astronauts placed scientific instruments and returnedlunar samples to Earth. Apollo 12 Lunar Module Intrepid prepares to descend towards the surface of the Moon. NASA photo. Contents Early history Space race Recent exploration Plans Past and future lunar missions See also References External links Early history The ancient Greek philosopher Anaxagoras (d. 428 BC) reasoned that the Sun and Moon were both giant spherical rocks, and that the latter reflected the light of the former. His non-religious view of the heavens was one cause for his imprisonment and eventual exile.[1] In his little book On the Face in the Moon's Orb, Plutarch suggested that the Moon had deep recesses in which the light of the Sun did not reach and that the spots are nothing but the shadows of rivers or deep chasms. -
Outer Space in Russia's Security Strategy
Outer Space in Russia’s Security Strategy Nicole J. Jackson Simons Papers in Security and Development No. 64/2018 | August 2018 Simons Papers in Security and Development No. 64/2018 2 The Simons Papers in Security and Development are edited and published at the School for International Studies, Simon Fraser University. The papers serve to disseminate research work in progress by the School’s faculty and associated and visiting scholars. Our aim is to encourage the exchange of ideas and academic debate. Inclusion of a paper in the series should not limit subsequent publication in any other venue. All papers can be downloaded free of charge from our website, www.sfu.ca/internationalstudies. The series is supported by the Simons Foundation. Series editor: Jeffrey T. Checkel Managing editor: Martha Snodgrass Jackson, Nicole J., Outer Space in Russia’s Security Strategy, Simons Papers in Security and Development, No. 64/2018, School for International Studies, Simon Fraser University, Vancouver, August 2018. ISSN 1922-5725 Copyright remains with the author. Reproduction for other purposes than personal research, whether in hard copy or electronically, requires the consent of the author(s). If cited or quoted, reference should be made to the full name of the author(s), the title, the working paper number and year, and the publisher. Copyright for this issue: Nicole J. Jackson, nicole_jackson(at)sfu.ca. School for International Studies Simon Fraser University Suite 7200 - 515 West Hastings Street Vancouver, BC Canada V6B 5K3 Outer Space in Russia’s Security Strategy 3 Outer Space in Russia’s Security Strategy Simons Papers in Security and Development No. -
Conference Program
Conference Program 24th WRMISS Conference Program: Tuesday 3rd September 2019 08.30 – 09:00 Registration 09.00 – 10:00 Opening 10.00 – 10:30 Scientific Session 1 10.30 – 11.30 Coffee/Tea Break 11.30 – 13:00 Scientific Session 2 13:00 – 14:00 Lunch 14.00 – 15:30 Scientific Session 3 15.30 – 16:30 Coffee/Tea Break 16:30 – 18.15 Scientific Session 4 Major of Athens, Ministry of Ministry of digital policy Ministry of Ministry of Development and Investment Opening speeches President of Hellenic Space Center Greek ESA‐ representative NASA Radiation Health Officer: Edward Semones Guenther Reitz, Marianthi Fragopoulou Welcome and Organisational Issues Scientific Session 1 Reviewing ISS‐member cancer and non‐cancer risk models and their Samy El‐Jaby differences for exploration class missions Scientific Session 2 Xiaojing Xu Validation of Trapped Proton Environments with EFT‐1 Measurements Solar Modulation, Forbush decreases and Solar Particle Events by AMS Claudio Cordi onboard ISS Validation of NASA’s Radiation Analysis Tools with ISS Radiation Martha Clowdsley Environment (REM) Measurements Scientific Session 3 Pawel Bilski Fluorescent Nuclear Track detectors based on LiF single crystals Lawrence Pinsky The Timepix 2 from the Medipix 2 Collaboration – First results The AMS‐02 experiment as a cosmic ray flux and radiation monitor on the Valerie Formato ISS Scientific Session 4 GCR flux and dose rates variations observed experimentally by 13 Liulin Tsvetan Dachev Type instruments between 1991 and 2019 Attila Hirn Pille Measurements on ISS (February -
Highlights in Space 2010
International Astronautical Federation Committee on Space Research International Institute of Space Law 94 bis, Avenue de Suffren c/o CNES 94 bis, Avenue de Suffren UNITED NATIONS 75015 Paris, France 2 place Maurice Quentin 75015 Paris, France Tel: +33 1 45 67 42 60 Fax: +33 1 42 73 21 20 Tel. + 33 1 44 76 75 10 E-mail: : [email protected] E-mail: [email protected] Fax. + 33 1 44 76 74 37 URL: www.iislweb.com OFFICE FOR OUTER SPACE AFFAIRS URL: www.iafastro.com E-mail: [email protected] URL : http://cosparhq.cnes.fr Highlights in Space 2010 Prepared in cooperation with the International Astronautical Federation, the Committee on Space Research and the International Institute of Space Law The United Nations Office for Outer Space Affairs is responsible for promoting international cooperation in the peaceful uses of outer space and assisting developing countries in using space science and technology. United Nations Office for Outer Space Affairs P. O. Box 500, 1400 Vienna, Austria Tel: (+43-1) 26060-4950 Fax: (+43-1) 26060-5830 E-mail: [email protected] URL: www.unoosa.org United Nations publication Printed in Austria USD 15 Sales No. E.11.I.3 ISBN 978-92-1-101236-1 ST/SPACE/57 *1180239* V.11-80239—January 2011—775 UNITED NATIONS OFFICE FOR OUTER SPACE AFFAIRS UNITED NATIONS OFFICE AT VIENNA Highlights in Space 2010 Prepared in cooperation with the International Astronautical Federation, the Committee on Space Research and the International Institute of Space Law Progress in space science, technology and applications, international cooperation and space law UNITED NATIONS New York, 2011 UniTEd NationS PUblication Sales no. -
Kibo HANDBOOK
Kibo HANDBOOK September 2007 Japan Aerospace Exploration Agency (JAXA) Human Space Systems and Utilization Program Group Kibo HANDBOOK Contents 1. Background on Development of Kibo ............................................1-1 1.1 Summary ........................................................................................................................... 1-2 1.2 International Space Station (ISS) Program ........................................................................ 1-2 1.2.1 Outline.........................................................................................................................1-2 1.3 Background of Kibo Development...................................................................................... 1-4 2. Kibo Elements...................................................................................2-1 2.1 Kibo Elements.................................................................................................................... 2-2 2.1.1 Pressurized Module (PM)............................................................................................ 2-3 2.1.2 Experiment Logistics Module - Pressurized Section (ELM-PS)................................... 2-4 2.1.3 Exposed Facility (EF) .................................................................................................. 2-5 2.1.4 Experiment Logistics Module - Exposed Section (ELM-ES)........................................ 2-6 2.1.5 JEM Remote Manipulator System (JEMRMS)............................................................ -
Molds Aboard the International Space Station
Mold Species in Dust from the International Space Station Identified and Quantified by Mold Specific Quantitative PCR Stephen J. Vesper a*, Wing Wongb C. Mike Kuoc, Duane L. Piersond a National Exposure Research Laboratory (NERL), United States (US) Environmental Protection Agency, Cincinnati, OH; b Enterprise Advisory Services Inc., Houston, TX c WYLE Laboratories Inc., Houston, TX d Johnson Space Center, National Aeronautics and Space Administration, Houston, TX *Corresponding Author: Stephen Vesper, US EPA, 26 West M.L. King Ave., M.L. 314, Cincinnati, Ohio 45268. Phone: 513-569-7367; email: [email protected] Abstract Dust was collected over a period of several weeks in 2007 from HEPA filters in the U.S. Laboratory Module of the International Space Station (ISS). The dust was returned on the Space Shuttle Atlantis, mixed, sieved, and the DNA was extracted. Using a DNA- based method called mold specific quantitative PCR (MSQPCR), 39 molds were measured in the dust. Potential opportunistic pathogens Aspergillus flavus and A. niger and potential moderate toxin producers Penicillium chrysogenum and P. brevicompactum were noteworthy. No cells of the potential opportunistic pathogens A. fumigatus, A. terreus, Fusarium solani or Candida albicans were detected. Keywords: International Space Station, mold specific quantitative PCR, Aspergillus 1 1. Introduction Since human space exploration began, microbes have traveled with us and are ubiquitous throughout the spacecraft. Previous studies have demonstrated that bacteria, including potential pathogens, were commonly isolated in the air, water, and on surfaces aboard the Mir Space Station [12] and the International Space Station (ISS) [1,6]. Biofilms were found in the water distribution lines on the Space Shuttle Discovery [5]. -
The European Launchers Between Commerce and Geopolitics
The European Launchers between Commerce and Geopolitics Report 56 March 2016 Marco Aliberti Matteo Tugnoli Short title: ESPI Report 56 ISSN: 2218-0931 (print), 2076-6688 (online) Published in March 2016 Editor and publisher: European Space Policy Institute, ESPI Schwarzenbergplatz 6 • 1030 Vienna • Austria http://www.espi.or.at Tel. +43 1 7181118-0; Fax -99 Rights reserved – No part of this report may be reproduced or transmitted in any form or for any purpose with- out permission from ESPI. Citations and extracts to be published by other means are subject to mentioning “Source: ESPI Report 56; March 2016. All rights reserved” and sample transmission to ESPI before publishing. ESPI is not responsible for any losses, injury or damage caused to any person or property (including under contract, by negligence, product liability or otherwise) whether they may be direct or indirect, special, inciden- tal or consequential, resulting from the information contained in this publication. Design: Panthera.cc ESPI Report 56 2 March 2016 The European Launchers between Commerce and Geopolitics Table of Contents Executive Summary 5 1. Introduction 10 1.1 Access to Space at the Nexus of Commerce and Geopolitics 10 1.2 Objectives of the Report 12 1.3 Methodology and Structure 12 2. Access to Space in Europe 14 2.1 European Launchers: from Political Autonomy to Market Dominance 14 2.1.1 The Quest for European Independent Access to Space 14 2.1.3 European Launchers: the Current Family 16 2.1.3 The Working System: Launcher Strategy, Development and Exploitation 19 2.2 Preparing for the Future: the 2014 ESA Ministerial Council 22 2.2.1 The Path to the Ministerial 22 2.2.2 A Look at Europe’s Future Launchers and Infrastructure 26 2.2.3 A Revolution in Governance 30 3. -
Commercialization of Russian Technology in Cooperation with American Companies
Stanford University CISAC Center for International Security and Cooperation The Center for International Security and Cooperation, part of Stanford University’s Institute for International Studies, is a multidisciplinary community dedicated to research and train- ing in the field of international security. The Center brings together scholars, policymakers, scientists, area specialists, members of the business community, and other experts to examine a wide range of international security issues. Center for International Security and Cooperation Stanford University Encina Hall Stanford, California 94305-6165 (415) 723-9625 http://www.stanford.edu/group/CISAC/ Commercialization of Russian Technology in Cooperation with American Companies David Bernstein June 1999 David Bernstein, an engineering research associate at Stanford University’s Center for Inter- national Security and Cooperation, participates in the Center’s Project on Industrial Restruc- turing and the Political Economy in Russia. The opinions expressed here are those of the author and do not represent positions of the Center, its supporters, or Stanford University. © 1999 by the Board of Trustees of the Leland Stanford Junior University ISBN 0-935371-53-2 i ii Contents I. Introduction 1 II. Background 5 III. Case Studies Introduction to Case Studies 17 Air Products & Chemicals, Incorporated 19 Boeing 21 Corning, Incorporated 27 Energia, Ltd. 29 NPO Energomash 33 FMC 37 General Electric 41 The State Scientific Research Institute of Aviation Systems (GosNIIAS) 43 Karpov Institute -
The Annual Compendium of Commercial Space Transportation: 2017
Federal Aviation Administration The Annual Compendium of Commercial Space Transportation: 2017 January 2017 Annual Compendium of Commercial Space Transportation: 2017 i Contents About the FAA Office of Commercial Space Transportation The Federal Aviation Administration’s Office of Commercial Space Transportation (FAA AST) licenses and regulates U.S. commercial space launch and reentry activity, as well as the operation of non-federal launch and reentry sites, as authorized by Executive Order 12465 and Title 51 United States Code, Subtitle V, Chapter 509 (formerly the Commercial Space Launch Act). FAA AST’s mission is to ensure public health and safety and the safety of property while protecting the national security and foreign policy interests of the United States during commercial launch and reentry operations. In addition, FAA AST is directed to encourage, facilitate, and promote commercial space launches and reentries. Additional information concerning commercial space transportation can be found on FAA AST’s website: http://www.faa.gov/go/ast Cover art: Phil Smith, The Tauri Group (2017) Publication produced for FAA AST by The Tauri Group under contract. NOTICE Use of trade names or names of manufacturers in this document does not constitute an official endorsement of such products or manufacturers, either expressed or implied, by the Federal Aviation Administration. ii Annual Compendium of Commercial Space Transportation: 2017 GENERAL CONTENTS Executive Summary 1 Introduction 5 Launch Vehicles 9 Launch and Reentry Sites 21 Payloads 35 2016 Launch Events 39 2017 Annual Commercial Space Transportation Forecast 45 Space Transportation Law and Policy 83 Appendices 89 Orbital Launch Vehicle Fact Sheets 100 iii Contents DETAILED CONTENTS EXECUTIVE SUMMARY . -
Russia Missile Chronology
Russia Missile Chronology 2007-2000 NPO MASHINOSTROYENIYA | KBM | MAKEYEV DESIGN BUREAU | MITT | ZLATOUST MACHINE-BUILDING PLANT KHRUNICHEV | STRELA PRODUCTION ASSOCIATION | AAK PROGRESS | DMZ | NOVATOR | TsSKB-PROGRESS MKB RADUGA | ENERGOMASH | ISAYEV KB KHIMMASH | PLESETSK TEST SITE | SVOBODNYY COSMODROME 1999-1996 KRASNOYARSK MACHINE-BUILDING PLANT | MAKEYEV DESIGN BUREAU | MITT | AAK PROGRESS NOVATOR | SVOBODNYY COSMODROME Last update: March 2009 This annotated chronology is based on the data sources that follow each entry. Public sources often provide conflicting information on classified military programs. In some cases we are unable to resolve these discrepancies, in others we have deliberately refrained from doing so to highlight the potential influence of false or misleading information as it appeared over time. In many cases, we are unable to independently verify claims. Hence in reviewing this chronology, readers should take into account the credibility of the sources employed here. Inclusion in this chronology does not necessarily indicate that a particular development is of direct or indirect proliferation significance. Some entries provide international or domestic context for technological development and national policymaking. Moreover, some entries may refer to developments with positive consequences for nonproliferation 2007-2000: NPO MASHINOSTROYENIYA 28 August 2007 NPO MASHINOSTROYENIYA TO FORM CORPORATION NPO Mashinostroyeniya is set to form a vertically-integrated corporation, combining producers and designers of various supply and support elements. The new holding will absorb OAO Strela Production Association (PO Strela), OAO Permsky Zavod Mashinostroitel, OAO NPO Elektromekhaniki, OAO NII Elektromekhaniki, OAO Avangard, OAO Uralskiy NII Kompositsionnykh Materialov, and OAO Kontsern Granit-Elektron. While these entities have acted in coordination for some time, formation of the new corporation has yet to be finalized. -
Of S.P. Korolev Rocket and Space Public Corporation Energia for 2013
OF S.P. KOROLEV ROCKET AND SPACE PUBLIC CORPORATION ENERGIA FOR 2013 This Annual Report of S.P. Korolev Rocket and Space Public Corporation Energia (also hereinafter called “OAO RSC Energia”, “RSC Energia”, “the Corporation”) by the 2013 performance is drawn up in accordance with the RF Government Decree No 1214 as of December 31, 2010 “On Improvement of the Procedure for Management of Open Joint-Stock Companies Whose Stock is in Federal Ownership and Federal State Unitary Enterprises” with due regard for the requirements set forth in the Order issued by the RF Federal Financial Markets Service No 11-46/pz-n as of October 4, 2011 “On Approval of the Provision on Information Disclosure of Issuers of Registered Securities”. This Annual Report was preliminarily approved by RSC Energia’s Board of Directors on April 29, 2014. Minutes No10 as of May 6, 2014. Accuracy of the data contained in this Annual Report was confirmed by RSC Energia’s Auditing Committee Report as of April 17, 2014. 2 TABLE OF CONTENTS KEY PERFORMANCE INDICATORS ........................................................................... 6 ON CORPORATION ACTIVITIES ................................................................................. 8 Corporation background ................................................................................................................................8 Corporation structure (its participation in subsidiary and affiliated companies) ...........................................9 Information about purchase and sale contracts for