Fig. S1. Related to Figure 1

20 ● ● Heat map of sample distances PCA Analysis A 20B ● ● ●

20 ● ● ● Stage 10 Genotype 300 Stage ● Stage2D Stage 250 4D OPC 10 Genotype200 ● 2D Genotype 10 150 300 Stage A Stage4D 100 B 2D Stage ● 2D 50 250 4D0 ● OPCOPC2D 0 OPC DIV24D 200 0 DIV4OPC Genotype0 Genotype 150 Thap1A +/+ ● Thap1A +/+ PC2: 14% variance Genotype B -/- ● Thap1 Genotype●● A -/- 100 PC2: 14% variance Thap1B −10 ● ●● AB PC2: 14% variance −10 50 ● −10 ● ● B ● 0 ●

mouse_Library_13_D7T34D mouse_Library_14_D3T34D mouse_Library_15_E8T34D mouse_Library_8_D3T32D mouse_Library_7_D7T32D mouse_Library_9_E8T32D mouse_Library_17_D6T34D mouse_Library_16_3FT34D mouse_Library_18_7FT34D mouse_Library_11_D6T32D mouse_Library_10_3FT32D mouse_Library_12_7FT32D mouse_Library_3_E8OPC mouse_Library_1_D7OPC mouse_Library_2_D3OPC mouse_Library_4_3FOPC mouse_Library_5_D6OPC mouse_Library_6_7FOPC ●

−20 −20 ●

−40 −20 0 20 −20 −40 −20 PC1: 49%0 variance20 PC1: 49% variance −40 −20 0 20 PC1: 49% variance

C Overrepresentation of THAP1-dependent pathways - GO Analysis Terms

DIV2

heparan sulfate proteoglycan metabolic process DNA damage response mouse_Library_13_D7T34D mouse_Library_14_D3T34D mouse_Library_15_E8T34D mouse_Library_8_D3T32D mouse_Library_7_D7T32D mouse_Library_9_E8T32D mouse_Library_17_D6T34D mouse_Library_16_3FT34D mouse_Library_18_7FT34D mouse_Library_11_D6T32D mouse_Library_10_3FT32D mouse_Library_12_7FT32D mouse_Library_3_E8OPC mouse_Library_1_D7OPC mouse_Library_2_D3OPC mouse_Library_4_3FOPC mouse_Library_5_D6OPC mouse_Library_6_7FOPC membrane biogenesis extracellular matrix organization

myelination GO Analysis - negative regulation of supramolecular fiber organization Biological Process (p<0.001) 0 2 4 6 8 10 Fold Enrichment DIV2 & DIV4

cell adhesion

biological adhesion

anatomical structure development GO Analysis - developmental process

0 2 4 6 8 Biological Process (p<0.001) Fold Enrichment Figure S2 - related to Figure 2

A Thap1 +/+ Thap1 -/- B Carbazole Assay 0.15 Thap1+/+ -/-

(AU) (AU) Thap1 **

DAPI 0.10

/ 525nm

O4 * / 0.05

HABP Absorbance Absorbance 0.00 OPC OL

C Secreted GAG / Media (µg/mg) D GAG / Homogenate (µg/mg)

OPC OL OPC OL

Thap1+/+ Thap1-/- Thap1+/+ Thap1-/- Thap1+/+ Thap1-/- Thap1+/+ Thap1-/-

CS 73.53 134.07 9.40 23.56 CS 151.64 405.42 169.35 550.80

HS 3.67 7.55 0.44 1.01 HS 46.85 171.20 79.74 121.03

HA 1.40 2.61 0.86 2.42 HA 161.77 186.62 290.16 448.82

F E Secreted Chondroitin Sulfate GAG / Media (µg/mg) Chondroitin Sulfate GAG / Homogenate (µg/mg)

OPC OL OPC OL Thap1+/+ Thap1-/- Thap1+/+ Thap1-/- Thap1+/+ Thap1-/- Thap1+/+ Thap1-/- C-4S 63.15 123.88 7.77 19.76 C-4S 134.74 376.49 150.48 472.26 C-6S 7.44 6.34 1.00 2.48 C-6S 13.62 13.40 15.21 48.29 C-2,6S 0.82 1.17 0.13 0.44 C-2,6S 0.25 1.72 0.28 10.14 C-4,6S 0.79 1.05 0.09 0.15 C-4,6S 2.09 5.00 2.33 5.22 Figure S3 - related to Figure 3 Figure S4 - related to Figure 4

β-glucuronidase activity in OPC & OL C β-glucuronidase activity in CNS *** A B *** ns 15 1×10-1 *** *** 10 +/flx 10 Thap1 1×10-2 OPC N-CKO OPC 1×10-3 5 OL OL

-4 -Glucuronidase

1×10 β -Glucuronidase 1 (Units / mg lysate)

β 0

0 2 4 6 8 (Units / mg lysate)

-Glucuronidae (units/Hr) Lysate (mg) CC β Cortex Striatum

D Cerebellum Pearson Correlation = 0.9407 ± 0.009 LAMP1Intensity

CS56 Intensity Figure S5- related to Figure 5

10000 *** *** *** *** 1000 +/flx 100 Thap1 Thap1+/flx;GusTg 10

(Units / mg lysate) 1 -Glucuronidase activity β CC Cortex Striatum Cerebellum SUPPLEMENTAL FIGURE LEGENDS Figure S1 related figure 1. THAP1 loss disrupts the extracellular matrix transcriptome (A) Heatmap for sample distances and (B) principal component analysis (PCA) showing the variance in the samples used for RNAseq analysis: 3 clonal lines for each genotype (Thap1+/+ and Thap1-/-) from 3 stages of OL cultures: OPC, DIV2 & DIV4. (C) Thap1+/+ vs Thap1-/- differentially expressed genes (DEG) selective for either DIV2 (703) or present at both DIV2 & DIV4 (277) used for enrichment analysis of GO (Gene Ontology) terms to identify overrepresented biological pathways. Graphs show the most significantly overrepresented GO terms (p<0.001, sorted as fold overrepresented) in OL from DIV2 (GENEONTOLOGY, GO - Biological Process), and from the DIV2 & DIV4 overlapping group (DAVID, GO - GO - Biological process)

Figure S2 related figure 2. Thap1 null oligodendrocytes accumulate and secrete excess glycosaminoglycans (A) Representative images demonstrating accumulation of HA-GAG (stained using hyaluronan binding protein, HABP; red) in Thap1-/- OL cultures (+T3-DIV4). Arrows indicate surrounding regions of select OL with HA-GAG accumulation. (B) Carbazole assay (demonstrating GAG content) of total cell homogenate extracted from Thap1+/+ and Thap1-/- OPC and OL (+T3-DIV4). Absorbance at 525 nm for OPC; Thap1+/+ = 0.066 AU ± 0.0006; Thap1-/- = 0.094 AU ± 0.0022; t-test: t(2) = 12.70; p = 0.006 & OL - Thap1+/+ = 0.036 AU ± 0.0023; Thap1-/- = 0.059 AU ± 0.0019; t-test: t(2) = 7.96; p = 0.015. Table displaying the estimated amount of (C-D) CS, HS and HA GAGs (�g/mg) and (E- F) composition of mono (C-4S, C-6S) and bi-sulfated (C-2,6S and C-4,6S) CS-GAGs (�g/mg) (C,E) secreted in the media or (D,F) from cell homogenate from Thap1+/+ and Thap1-/- OPC and OL (+T3-DIV4) using GRIL LC/MS analysis.

Figure S3 related figure 3. Excess glycosaminoglycan secretion by Thap1 null cells impairs oligodendroglial maturation via a non-cell autonomous mechanism Schematic illustrating co-culture experimental paradigm to test for paracrine effects of GAGs secreted by the OL lineage. Thap1 null (Thap1-/-) OL were co-cultured with LV- GFP labelled control (Thap1+/+; GFP) OPC at 10:1 ratio in differentiation media for four days (+T3). The two possible outcomes from this experimental paradigm are depicted in the illustration.

Figure S4 related figure 4. β-glucuronidase activity during oligodendrocyte differentiation. (A) β-glucuronidase activity (Units / Hr) for Thap1+/+ OPC and OL (+T3-DIV4) lysate (0 - 8 μg; x-axis; STAR Methods). (B) Normalized β-glucuronidase activity (Units/mg Lysate) for OPC = 8.71 U / mg ± 0.27 and OL = 7.97 U / mg ± 0.18; t-test: t(2) = 2.18; p = 0.16). (C) β-glucuronidase activity in multiple brain regions (cerebral cortex, corpus callosum, striatum and cerebellum) of P21 THAP1 N-CKO (Thap1flx/-; nestin-Cre+) and control (Thap1+/flx) mice. Bar graph shows mean ± SEM values of normalized β-glucuronidase activity Units/Lysate (mg). Cerebral cortex - Thap1+/flx = 10.32 U / mg ± 0.43 ; N-CKO = 4.76 U / mg ± 0.106; t-test: p < 0.0001; corpus callosum - Thap1+/flx = 13.49 U / mg ± 0.33 ; N-CKO = 5.38 U / mg ± 0.129; t-test: p < 0.0001; striatum - Thap1+/flx = 9.98 U / mg ± 0.183 ; N-CKO = 5.10 U / mg ± 0.10; t-test: p < 0.0001 and cerebellum - Thap1+/flx = 14.97 U / mg ± 0.552 ; N-CKO = 5.58 U / mg ± 0.117; t-test: p < 0.0001) from P21 mice. (D) Pearson’s coefficient value shows ~ 95% colocalization (R = 0.94 ± 0.009; multiple region of interest (ROI) for N=50 cells) for CS-GAG (CS-56) and lysosomes (LAMP1) in OL (DIV4). Graph demonstrating co-localization of CS-56 and LAMP1 pixels for the image represented in FIg. 5N calculated using Image J.

Figure S5 related figure 5. β-glucuronidase overexpression in CNS tissue. β-glucuronidase activity in multiple brain regions (cerebral cortex, corpus callosum, striatum and cerebellum) of P21 Thap1+/flx and Thap1+/flx;TgGUS mice. Bar graph shows mean ± SEM values of normalized β-glucuronidase activity Units/Lysate (mg). Cerebral cortex - Thap1+/flx = 10.32 U / mg ± 0.43 ; Thap1+/flx;TgGUS = 2402 U / mg ± 120.6; t-test: p < 0.0001; corpus callosum - Thap1+/flx = 13.49 U / mg ± 0.33 ; Thap1+/flx;TgGUS = 2208 U / mg ± 140.2; t-test: p < 0.0001; striatum - Thap1+/flx = 9.98 U / mg ± 0.183 ; Thap1+/ flx;TgGUS = 2056 U / mg ± 110.3; t-test: p < 0.0001 and cerebellum - Thap1+/flx = 14.97 U / mg ± 0.552 ; Thap1+/flx;TgGUS = 2078 U / mg ± 724.9; t-test: p < 0.0001. Table S1: Thap1 +/+ Vs Thap1 -/- DEG - OPC Symbol Entrez Gene IDMGI Gene/Markerlog2FoldChange.OPC ID Gm13841 665032 MGI:3650890 6.23655312 Anxa6 11749 MGI:88255 5.53098858 Pttg1 30939 MGI:1353578 5.10951903 Gls 14660 MGI:95752 5.07292798 Cyb5 109672 MGI:1926952 4.71999895 Becn1 56208 MGI:1891828 4.65986585 Rnu3a 19850 MGI:97977 4.60437764 BC002163 170658 MGI:3612445 4.58577533 Gm24119 MGI:5453896 4.54253579 Cast 12380 MGI:1098236 4.5420729 Grb10 14783 MGI:103232 4.34730574 Mtx2 53375 MGI:1859652 4.3130571 Mpg 268395 MGI:97073 4.30652836 Chek1 12649 MGI:1202065 4.26920775 Zmym3 56364 MGI:1927231 4.19365533 Gm23946 MGI:5453723 4.17892506 Ikbkg 16151 MGI:1338074 4.14781631 Gm26316 MGI:5456093 4.00594565 Mob1b 68473 MGI:1915723 3.99843807 Gm9923 100040505 MGI:3704365 3.98440042 Ddx5 13207 MGI:105037 3.93903572 4933434E20Rik 99650 MGI:1914027 3.80517724 Gm24407 MGI:5454184 3.79625284 Igsf1 209268 MGI:2147913 3.76136572 Wnk1 232341 MGI:2442092 3.76009824 Gm22973 MGI:5452750 3.75193685 Gm12663 105274305 MGI:3652168 3.73161149 Urm1 68205 MGI:1915455 3.6503159 Gm15093 100039890 MGI:3712496 3.64071013 Gm10439 382243 MGI:3710525 3.63068496 Vax1 22326 MGI:1277163 3.61313008 Ift20 55978 MGI:1915585 3.61197371 Tuba1c 22146 MGI:1095409 3.60134524 Mtch2 56428 MGI:1929260 3.59670124 Gm22614 MGI:5452391 3.57908954 Fndc3c1 333564 MGI:2685630 3.57634117 Snora23 100379145 MGI:3819494 3.57421696 Snrpb2 20639 MGI:104805 3.55768887 Abca6 76184 MGI:1923434 3.55346446 Gm21738 MGI:5433902 3.54830341 A730017C20Rik 225583 MGI:2442934 3.52225805 Luzp4 434865 MGI:3708816 3.50201774 Gm25890 MGI:5455667 3.46201989 Terc 21748 MGI:109558 3.44328045 Kdm5a 214899 MGI:2136980 3.43607442 ACEA_U3 No associated gene3.41644978 Gm9732 108168154 MGI:3796514 3.41141408 Fuca2 66848 MGI:1914098 3.40516829 Epc1 13831 MGI:1278322 3.38390407 Rnu2-10 19848 MGI:97976 3.37608496 Gm24265 MGI:5454042 3.36935071 Hnrnpm 76936 MGI:1926465 3.35695877 Scara3 219151 MGI:2444418 3.3560733 Gm23971 MGI:5453748 3.34900404 Efcab1 66793 MGI:1914043 3.34831829 Eftud2 20624 MGI:1336880 3.34034714 Gm10719 MGI:3641690 3.33575597 Ube2q2 109161 MGI:2388672 3.33181713 Ddx26b 236790 MGI:2442593 3.31525822 Slc25a39 68066 MGI:1196386 3.31273133 Ott 18422 MGI:107573 3.30641047 Gm15085 100039934 MGI:3712210 3.27382469 Gm15526 108169144 MGI:3782973 3.27382469 Atrx 22589 MGI:103067 3.27382469 Gm12338 654359 MGI:3650622 3.27382469 Prkrip1 66801 MGI:1914051 3.27051169 Gnb2 14693 MGI:95784 3.25047511 Akr1b3 11677 MGI:1353494 3.24063414 U3 No associated gene3.23936619 Rpl3-ps1 100043000 MGI:3644217 3.23868048 Rsad2 58185 MGI:1929628 3.2370975 Ubxn6 66530 MGI:1913780 3.23434156 Ccnl1 56706 MGI:1922664 3.20455617 2810008D09Rik 76972 MGI:1924222 3.20455617 Mum1l1 245631 MGI:2445062 3.20290589 Thap1 73754 MGI:1921004 3.18936273 Gpr176 381413 MGI:2685858 3.18811299 Aard 239435 MGI:2181621 3.1854062 Atp5f1 11950 MGI:1100495 3.18324937 Tph2 216343 MGI:2651811 3.18187995 Sptlc2 20773 MGI:108074 3.17126781 Atad5 237877 MGI:2442925 3.14704415 Copa 12847 MGI:1334462 3.13575688 Sun1 77053 MGI:1924303 3.13180475 Clk1 12747 MGI:107403 3.12884903 Ptbp1 19205 MGI:97791 3.12665023 Chst5 56773 MGI:1931825 3.11300141 Gm14150 100043840 MGI:3651006 3.11210595 Osgep 66246 MGI:1913496 3.10060019 Sh3d19 27059 MGI:1350923 3.09521736 Smarca5 93762 MGI:1935129 3.09162049 Inip 66209 MGI:1913459 3.08433244 Rps27l 67941 MGI:1915191 3.08339438 1810058I24Rik 67705 MGI:1914955 3.07398651 Ncapg 54392 MGI:1930197 3.06404101 Sap18 20220 MGI:1277978 3.05419267 1600020E01Rik 72012 MGI:1919262 3.04840365 Eya4 14051 MGI:1337104 3.04159952 Gm11868 667251 MGI:3650507 3.02963396 Xpr1 19775 MGI:97932 3.02920609 Gm11520 102640811 MGI:3650534 3.02048148 Srsf10 14105 MGI:1333805 3.01750427 Sec11a 56529 MGI:1929464 3.00659276 Meis1 17268 MGI:104717 3.00391436 Gm15109 100039545 MGI:3705842 3.00384331 Lias 79464 MGI:1934604 3.00371191 Zfp429 72807 MGI:1920057 2.99797602 Msl3 17692 MGI:1341851 2.99703925 Gm15080 666184 MGI:3712217 2.99324773 Sema3e 20349 MGI:1340034 2.99205784 Echdc2 52430 MGI:1289238 2.98798998 Zc3h7a 106205 MGI:2445044 2.98029088 Eif4a2 13682 MGI:106906 2.97988114 Pop5 117109 MGI:2151221 2.97132392 Shisa7 232813 MGI:3605641 2.9694143 Supt6 20926 MGI:107726 2.96026853 Ganc 76051 MGI:1923301 2.95597992 Srsf5 20384 MGI:98287 2.95012517 Afap1l1 106877 MGI:2147199 2.94689716 Tmx2 66958 MGI:1914208 2.9451896 Gm24950 MGI:5454727 2.94350406 Zcchc7 319885 MGI:2442912 2.94148199 Gm23849 MGI:5453626 2.94050632 Cgrrf1 68755 MGI:1916368 2.93724783 Gm15091 382244 MGI:3712222 2.93644633 Fcf1 73736 MGI:1920986 2.92937838 Ercc8 71991 MGI:1919241 2.91612052 Mrps24 64660 MGI:1928142 2.91605099 Tusc3 80286 MGI:1933134 2.91513105 Rnf6 74132 MGI:1921382 2.9131746 Gm24497 MGI:5454274 2.90831311 Gm15051 105242658 MGI:3705155 2.90751548 Cox4i1 12857 MGI:88473 2.90678602 Stxbp1 20910 MGI:107363 2.90326143 Eps8 13860 MGI:104684 2.90018258 Dcc 13176 MGI:94869 2.89737093 Slc35f2 72022 MGI:1919272 2.89292508 Cbx3 12417 MGI:108515 2.89251615 Lyrm5 67636 MGI:1914886 2.89219202 Gm22317 MGI:5452094 2.88895145 Clk4 12750 MGI:1098551 2.88709283 Sec61g 20335 MGI:1202066 2.88702575 Ppia 268373 MGI:97749 2.87851054 Fxr2 23879 MGI:1346074 2.87619288 Taf9 108143 MGI:1888697 2.8732904 Gm15097 434869 MGI:3710639 2.86471566 Mib1 225164 MGI:2443157 2.86295142 Abhd1 57742 MGI:1931013 2.85610148 Alcam 11658 MGI:1313266 2.85216468 Kcnk2 16526 MGI:109366 2.85197097 Rnasek 52898 MGI:106369 2.84132233 Jtb 23922 MGI:1346082 2.83978103 Hemk1 69536 MGI:1916786 2.83871709 Mkln1 27418 MGI:1351638 2.83554709 Vrk2 69922 MGI:1917172 2.82982174 Scp2 20280 MGI:98254 2.82844564 Ggnbp2 217039 MGI:2387356 2.78279091 Fam115c 232748 MGI:2385258 2.78230475 Gm14303 629957 MGI:3651379 2.77693135 Clint1 216705 MGI:2144243 2.77648392 Gpcpd1 74182 MGI:104898 2.76569829 Dirc2 224132 MGI:2387188 2.7555652 Gm25679 MGI:5455456 2.75497029 Rad23a 19358 MGI:105126 2.74489584 Phf20 228829 MGI:2444148 2.73303449 Rasef 242505 MGI:2448565 2.73184672 Cntn4 269784 MGI:1095737 2.73081439 Gm25360 MGI:5455137 2.73052964 Serhl 68607 MGI:1890404 2.73017451 Rbm39 170791 MGI:2157953 2.73014335 Mapk6 50772 MGI:1354946 2.7211612 Tmem245 242474 MGI:2445107 2.71631823 Zfp536 243937 MGI:1926102 2.71219176 2700094K13Rik 72657 MGI:1919907 2.6993178 Rnf112 22671 MGI:106611 2.69784118 Sub1 20024 MGI:104811 2.69646855 Gm25939 MGI:5455716 2.68966377 Sytl2 83671 MGI:1933366 2.68150595 Luc7l2 192196 MGI:2183260 2.67104379 Tarbp2 21357 MGI:103027 2.66885214 Rbm25 67039 MGI:1914289 2.66859107 Rab2b 76338 MGI:1923588 2.66821177 Cox18 231430 MGI:2448532 2.66061933 Flad1 319945 MGI:2443030 2.6582921 Commd1 17846 MGI:109474 2.65374891 Ifrd1 15982 MGI:1316717 2.65208899 Gemin8 237221 MGI:2384300 2.65082934 Fen1 14156 MGI:102779 2.64081435 Gm23472 MGI:5453249 2.63647069 Ccnc 51813 MGI:1858199 2.63328006 Mical1 171580 MGI:2385847 2.63284565 Itgb3 16416 MGI:96612 2.63276514 Mrps34 79044 MGI:1930188 2.62667746 Zfp800 627049 MGI:1889334 2.6134608 Ttll7 70892 MGI:1918142 2.60046419 Tomm5 68512 MGI:1915762 2.5996091 Nxt2 237082 MGI:2147914 2.59651237 Pdp1 381511 MGI:2685870 2.59032029 Arfgap1 228998 MGI:2183559 2.5781866 Socs6 54607 MGI:1924885 2.56091545 Mtm1 17772 MGI:1099452 2.55319775 Zwint 52696 MGI:1289227 2.54862146 Sparc 20692 MGI:98373 2.54420355 Eif3s6-ps2 16343 MGI:103204 2.53658293 Commd6 66200 MGI:1913450 2.53047388 Cyth2 19158 MGI:1334255 2.51107871 Zfp61 22719 MGI:99663 2.50399933 Atp5b 11947 MGI:107801 2.48553007 Gm20633 MGI:5313080 2.4822565 Gas5 14455 MGI:95659 2.47834495 Fance 72775 MGI:1920025 2.47408421 Hsd3b7 101502 MGI:2141879 2.47102712 Bdh1 71911 MGI:1919161 2.45606526 Ehmt1 77683 MGI:1924933 2.44231271 Rpl10a 19896 MGI:1343877 2.43795555 Cd302 66205 MGI:1913455 2.43420773 Kcnq3 110862 MGI:1336181 2.41760436 Zfyve27 319740 MGI:1919602 2.41239026 Wsb1 78889 MGI:1926139 2.40850903 Amt 434437 MGI:3646700 2.4084006 Plin2 11520 MGI:87920 2.39960199 Prrc2c 226562 MGI:1913754 2.39760358 Fam89b 17826 MGI:106595 2.38749576 Rpl9 20005 MGI:1298373 2.38182093 Heatr3 234549 MGI:2444491 2.36913069 Exoc4 20336 MGI:1096376 2.36307288 Thrap3 230753 MGI:2442637 2.36080242 Hist1h2ad 319165 MGI:2448289 2.34579194 Ttpal 76080 MGI:1923330 2.33163827 Rtn4 68585 MGI:1915835 2.32557717 Prickle1 106042 MGI:1916034 2.3078399 Thoc2 331401 MGI:2442413 2.30024035 Mrps10 64657 MGI:1928139 2.29134717 Gm24305 MGI:5454082 2.28918261 Snx16 74718 MGI:1921968 2.27529415 Gm22513 MGI:5452290 2.22609285 Npepl1 228961 MGI:2448523 2.22464456 Mapk9 26420 MGI:1346862 2.22033877 Tmlhe 192289 MGI:2180203 2.21591813 Tmem55b 219024 MGI:2448501 2.20827083 Gm25835 MGI:5455612 2.20333099 Gan 209239 MGI:1890619 2.20330987 Pter 19212 MGI:107372 2.19863613 Pik3r3 18710 MGI:109277 2.19333449 Hexim2 71059 MGI:1918309 2.19016826 Rpl39 67248 MGI:1914498 2.17961744 Ndufa7 66416 MGI:1913666 2.17678952 Serpinb6a 20719 MGI:103123 2.16994677 Mgat1 17308 MGI:96973 2.15769159 Mrpl51 66493 MGI:1913743 2.12584845 Ppap2c 50784 MGI:1354945 2.12246312 Setd1a 233904 MGI:2446244 2.11428744 Prpf38b 66921 MGI:1914171 2.1086207 Ubap2l 74383 MGI:1921633 2.10479689 Opa1 74143 MGI:1921393 2.08951128 Hnrnpab 15384 MGI:1330294 2.0671127 Fbxw9 68628 MGI:1915878 2.06344381 Kdm4b 193796 MGI:2442355 2.05985812 Cdk4 12567 MGI:88357 2.04758892 Tmem98 103743 MGI:1923457 2.04303464 Fuom 69064 MGI:1916314 2.03706285 Nme1 18102 MGI:97355 2.02605812 5730508B09Rik 70617 MGI:1917867 2.01168418 Dera 232449 MGI:1913762 2.01048538 Def8 23854 MGI:1346331 2.00979791 Wdr45 54636 MGI:1859606 2.00652976 Fancb 237211 MGI:2448558 1.99728234 Nudt9 74167 MGI:1921417 1.98884934 Snord17 100313519 MGI:3819523 1.98639939 Cpeb4 67579 MGI:1914829 1.98523199 Eif4a1 13681 MGI:95303 1.97628498 6720427I07Rik 109186 MGI:1924398 1.97237629 Sfi1 78887 MGI:1926137 1.96891576 Gm26244 MGI:5456021 1.96401822 Tpm1 22003 MGI:98809 1.9605947 Usp34 17847 MGI:109473 1.94731303 Arid4b 94246 MGI:2137512 1.93242948 Rps28 54127 MGI:1859516 1.92705815 Gt(ROSA)26Sor 14910 MGI:104735 1.92461838 Lurap1l 52829 MGI:106510 1.92460047 Map3k15 270672 MGI:2448588 1.92361156 Col9a3 12841 MGI:894686 1.91979473 Bche 12038 MGI:894278 1.91679683 Capn7 12339 MGI:1338030 1.91672419 Anks1b 77531 MGI:1924781 1.91181979 Bace1 23821 MGI:1346542 1.88648989 Fam58b 69109 MGI:1916359 1.88192925 Aars2 224805 MGI:2681839 1.87059139 Kcnk1 16525 MGI:109322 1.86551899 Slc39a11 69806 MGI:1917056 1.85757558 Hecw2 329152 MGI:2685817 1.85014039 Ciapin1 109006 MGI:1922083 1.82739504 Rpl36al 66483 MGI:1913733 1.82050502 Hs6st2 50786 MGI:1354959 1.8198048 Dhx32 101437 MGI:2141813 1.81968805 Map4k5 399510 MGI:1925503 1.8165365 G6pc3 68401 MGI:1915651 1.78733173 Hist1h2bj 319183 MGI:2448388 1.78636096 Dst 13518 MGI:104627 1.76572824 Snora73b 100306945 MGI:4360049 1.75357937 9930021J03Rik 240613 MGI:2444398 1.74805736 Tyw5 68736 MGI:1915986 1.73298222 Nol3 78688 MGI:1925938 1.72902071 Dlg1 13383 MGI:107231 1.72859372 Inpp5k 19062 MGI:1194899 1.7285083 Slirp 380773 MGI:1916394 1.70352452 Sdf2 20316 MGI:108019 1.69529939 Med30 69790 MGI:1917040 1.69234673 Snrnp35 76167 MGI:1923417 1.68801238 Mia3 338366 MGI:2443183 1.67864762 Exosc8 69639 MGI:1916889 1.67310964 Crbn 58799 MGI:1913277 1.66329711 Gadd45gip1 102060 MGI:1914947 1.66155449 Mrps14 64659 MGI:1928141 1.65907569 Rpl30 19946 MGI:98037 1.6586925 Anxa2 12306 MGI:88246 1.6334521 Eral1 57837 MGI:1889295 1.6192406 Gm20900 105243593 MGI:5434256 1.60841559 Nup37 69736 MGI:1919964 1.60227366 Hist1h2bm 319186 MGI:2448404 1.58952853 Hist1h2ae 319166 MGI:2448290 1.58052275 Txn1 22166 MGI:98874 1.57994808 Psma3 19167 MGI:104883 1.57124226 Tbc1d7 67046 MGI:1914296 1.57087358 Cnep1r1 382030 MGI:1921981 1.56827461 Gm26917 MGI:5504032 1.55904383 Atp5j 11957 MGI:107777 1.55877729 Irgm1 15944 MGI:107567 1.54780647 Inpp5a 212111 MGI:2686961 1.54372451 Uqcrq 22272 MGI:107807 1.54217649 Tmem199 195040 MGI:2144113 1.53248286 Ap2b1 71770 MGI:1919020 1.52247136 Hist1h4k 319160 MGI:2448439 1.52009843 Tcp1 21454 MGI:98535 1.51032954 Sqstm1 18412 MGI:107931 1.50000149 L2hgdh 217666 MGI:2384968 1.494838 Hist1h2bb 319178 MGI:2448377 1.49458754 Hist1h2bk 319184 MGI:2448399 1.4928497 Uqcr10 66152 MGI:1913402 1.49068747 Nme2 18103 MGI:97356 1.47882672 Dhrs13 70451 MGI:1917701 1.46205981 Ndufb2 68198 MGI:1915448 1.46194206 Mrpl55 67212 MGI:1914462 1.45711222 Chd9 109151 MGI:1924001 1.45231099 Wdr36 225348 MGI:1917819 1.4519157 Rpl35a 57808 MGI:1928894 1.44922459 Utp14b 195434 MGI:2445092 1.44246386 Tpi1 21991 MGI:98797 1.43948374 Hist1h3i 319153 MGI:2448350 1.43403339 Mtmr7 54384 MGI:1891693 1.42979954 Crk 12928 MGI:88508 1.42060043 Cenpw 66311 MGI:1913561 1.41610874 Nhlrc3 212114 MGI:2444520 1.41369119 Rps29 20090 MGI:107681 1.41012923 Mif 17319 MGI:96982 1.40344115 Klhdc4 234825 MGI:2384569 1.40193572 Rpl23a 268449 MGI:3040672 1.39531734 Dut 110074 MGI:1346051 1.39047017 Sap30l 50724 MGI:1354709 1.37520299 Mrpl14 68463 MGI:1333864 1.37115345 Hist2h2bb 319189 MGI:2448413 1.37075811 Mrps17 66258 MGI:1913508 1.37065533 Rnf113a2 66381 MGI:1913631 1.36697709 Hist4h4 320332 MGI:2448443 1.36615688 Rpl38 67671 MGI:1914921 1.36522622 Grb14 50915 MGI:1355324 1.36436067 Hint1 15254 MGI:1321133 1.36417911 Pigs 276846 MGI:2687325 1.36387119 Cd63 12512 MGI:99529 1.36032254 Dnajc19 67713 MGI:1914963 1.35094199 Prmt6 99890 MGI:2139971 1.34411051 Ppfibp1 67533 MGI:1914783 1.33802226 Ivns1abp 117198 MGI:2152389 1.32649143 Dzip3 224170 MGI:1917433 1.32645997 Hist1h2bg 319181 MGI:2448386 1.31275014 Gnb2l1 14694 MGI:101849 1.3056247 Rsrc2 208606 MGI:1913489 1.30134123 Mfn1 67414 MGI:1914664 1.29496286 Aurkaip1 66077 MGI:1913327 1.29243707 Prdx4 53381 MGI:1859815 1.2766448 Tamm41 68971 MGI:1916221 1.27043574 Ppp2r3c 59032 MGI:1930009 1.26595732 Rnmtl1 67390 MGI:1914640 1.2550376 Rpl26 19941 MGI:106022 1.24563072 Rpl27 19942 MGI:98036 1.23570422 Tvp23b 67510 MGI:1914760 1.23193363 Rps20 67427 MGI:1914677 1.22856069 Map3k10 269881 MGI:1346879 1.22065627 Blmh 104184 MGI:1345186 1.21521274 Fam117a 215512 MGI:2144564 1.21312723 Ebpl 68177 MGI:1915427 1.20694371 Ndufb4 68194 MGI:1915444 1.19871314 Cenpv 73139 MGI:1920389 1.19729066 Dcun1d2 102323 MGI:2142792 1.18924851 Magt1 67075 MGI:1914325 1.18797045 Otud6b 72201 MGI:1919451 1.17935774 Lrrn1 16979 MGI:106038 1.17798656 Paip1 218693 MGI:2384993 1.17010324 Arl6 56297 MGI:1927136 1.16762659 Skap2 54353 MGI:1889206 1.15816382 Ndufb11 104130 MGI:1349919 1.15786468 Snhg4 100503380 MGI:4937091 1.15540884 Mrpl53 68499 MGI:1915749 1.14973053 Gsr 14782 MGI:95804 1.14914136 Arf6 11845 MGI:99435 1.14551992 Snhg5 72655 MGI:1919905 1.14448074 1810043H04Rik 208501 MGI:1913676 1.13706366 1110004E09Rik 68001 MGI:1915251 1.13600925 Slc35b1 110172 MGI:1343133 1.13547872 Mrpl33 66845 MGI:2137225 1.11820746 Rps27a 78294 MGI:1925544 1.11783562 Cnot6 104625 MGI:2144529 1.11084447 Fkbp9 27055 MGI:1350921 1.10779334 Dctpp1 66422 MGI:1913672 1.10246658 2810428I15Rik 66462 MGI:1913712 1.0992855 Nenf 66208 MGI:1913458 1.09408551 Nsmce4a 67872 MGI:1915122 1.08365677 Cox16 66272 MGI:1913522 1.07325405 C1ql3 227580 MGI:2387350 1.07222498 Tsr1 104662 MGI:2144566 1.06995978 Robo1 19876 MGI:1274781 1.06989847 Dusp3 72349 MGI:1919599 1.06708195 Galk1 14635 MGI:95730 1.06652899 Dhps 330817 MGI:2683592 1.06377739 Tecr 106529 MGI:1915408 1.06142414 Grwd1 101612 MGI:2141989 1.05237546 Psmb3 26446 MGI:1347014 1.05177258 mt-Co2 17709 MGI:102503 1.05121134 Tmbim4 68212 MGI:1915462 1.04474572 Vdac1 22333 MGI:106919 1.03970454 Ccdc43 52715 MGI:1289318 1.03784107 Acadvl 11370 MGI:895149 1.035533 Dtnbp1 94245 MGI:2137586 1.03372592 Anapc13 69010 MGI:1916260 1.03310596 Haus3 231123 MGI:2387633 1.03247944 Sf3b5 66125 MGI:1913375 1.03142473 Gm10020 100039748 MGI:3642192 1.03065223 Ndufc1 66377 MGI:1913627 1.02809321 Mrpl3 94062 MGI:2137204 1.02474756 Sec61b 66212 MGI:1913462 1.02422865 Bpgm 12183 MGI:1098242 1.01939565 Emc6 66048 MGI:1913298 1.01907378 Dnajc2 22791 MGI:99470 1.01903705 Gins4 109145 MGI:1923847 1.01871589 Col16a1 107581 MGI:1095396 1.01816387 Pnrc1 108767 MGI:1917838 1.01071644 Blvra 109778 MGI:88170 0.99292261 Serinc5 218442 MGI:2444223 0.99113187 Bex1 19716 MGI:1328321 0.98761001 Ano10 102566 MGI:2143103 0.984342 Ptges3 56351 MGI:1929282 0.98354012 Nhp2 52530 MGI:1098547 0.98245476 Abhd17b 226016 MGI:1917816 0.98141536 Stk24 223255 MGI:2385007 0.97970486 Pfkl 18641 MGI:97547 0.97602458 Bod1 69556 MGI:1916806 0.97554358 Crebzf 233490 MGI:2675296 0.97000113 Cox7a2 12866 MGI:1316715 0.96619496 Aprt 11821 MGI:88061 0.95154752 Rpl19 19921 MGI:98020 0.9476035 Atp5k 11958 MGI:106636 0.94570152 Aarsd1 69684 MGI:1916934 0.94414942 P4hb 18453 MGI:97464 0.93916692 H2-Ke2 14976 MGI:95908 0.93325466 Gm22009 MGI:5451786 0.93022785 Dhx40 67487 MGI:1914737 0.92957671 Uqcrfs1 66694 MGI:1913944 0.92631657 Hnrnpa2b1 53379 MGI:104819 0.91980661 Zfp292 30046 MGI:1353423 0.91801743 Naa50 72117 MGI:1919367 0.91333322 Esd 13885 MGI:95421 0.91290964 Ndufs6 407785 MGI:107932 0.91256545 Mrpl46 67308 MGI:1914558 0.91152539 Cox8a 12868 MGI:105959 0.91043718 Ap3m1 55946 MGI:1929212 0.90770878 Npm1 18148 MGI:106184 0.90753658 Hspe1 15528 MGI:104680 0.90323975 Guk1 14923 MGI:95871 0.90138856 H2afz 51788 MGI:1888388 0.8975291 Tmed5 73130 MGI:1921586 0.89187635 Rabep1 54189 MGI:1860236 0.88992004 Rpl23 27546 MGI:1196611 0.88960559 Abce1 24015 MGI:1195458 0.88212086 Cstf3 228410 MGI:1351825 0.88175805 Mpdu1 24070 MGI:1346040 0.87787224 Fam92a 68099 MGI:1915349 0.86911839 Sod1 20655 MGI:98351 0.86900616 Atp5c1 11949 MGI:1261437 0.86644227 Pphln1 223828 MGI:1917029 0.86312906 Xpnpep1 170750 MGI:2180003 0.86273489 Sec23a 20334 MGI:1349635 0.86037935 Naa38 76522 MGI:1923772 0.85699329 Dazap1 70248 MGI:1917498 0.84917526 Nop10 66181 MGI:1913431 0.84250358 Hspd1 15510 MGI:96242 0.84068165 Coq2 71883 MGI:1919133 0.8406205 U2surp 67958 MGI:1915208 0.84006005 Srp68 217337 MGI:1917447 0.83888557 Ofd1 237222 MGI:1350328 0.83278333 Sucla2 20916 MGI:1306775 0.83118943 Lsm4 50783 MGI:1354692 0.82067242 Mzt1 76789 MGI:1924039 0.81681325 Gm13456 666531 MGI:3651389 0.81664503 Sptan1 20740 MGI:98386 0.81206173 2410127L17Rik 67383 MGI:1914633 0.80405944 Trappc4 60409 MGI:1926211 0.80257399 Omg 18377 MGI:106586 0.79864204 Aatf 56321 MGI:1929608 0.79427171 Dcaf7 71833 MGI:1919083 0.79183381 Aldoa 11674 MGI:87994 0.79114132 Uba5 66663 MGI:1913913 0.79097484 Pithd1 66193 MGI:1913443 0.78858047 Hgsnat 52120 MGI:1196297 0.786794 Gsn 227753 MGI:95851 0.7860208 Sord 20322 MGI:98266 0.78349911 Impact 16210 MGI:1098233 0.78082696 Ptcd3 69956 MGI:1917206 0.77947065 Sec31a 69162 MGI:1916412 0.77794593 mt-Nd4 17719 MGI:102498 0.77671518 Psmd13 23997 MGI:1345192 0.7693399 Ube2j1 56228 MGI:1926245 0.76893992 Prdx1 18477 MGI:99523 0.76492365 Gpsm2 76123 MGI:1923373 0.76059137 Tnpo1 238799 MGI:2681523 0.7561932 Kdelr2 66913 MGI:1914163 0.75595192 Copb1 70349 MGI:1917599 0.75399822 Ybx1 22608 MGI:99146 0.75062189 Gatad1 67210 MGI:1914460 0.74962824 Psip1 101739 MGI:2142116 0.72571394 Derl1 67819 MGI:1915069 0.71652049 Tmem147 69804 MGI:1915011 0.70393512 Smc6 67241 MGI:1914491 0.70183357 Zmpste24 230709 MGI:1890508 0.69450002 1110037F02Rik 66185 MGI:1913435 0.69374242 Tmem168 101118 MGI:1921794 0.68802626 Tsen34 66078 MGI:1913328 0.68713001 Srp9 27058 MGI:1350930 0.67584172 Srsf6 67996 MGI:1915246 0.66917777 Surf4 20932 MGI:98445 0.6675297 Tgoln1 22134 MGI:105080 0.66644431 Cdc16 69957 MGI:1917207 0.65841289 Dnajc10 66861 MGI:1914111 0.65153005 Tomm70a 28185 MGI:106295 0.62954639 Efr3a 76740 MGI:1923990 0.62603478 Impad1 242291 MGI:1915720 0.61103319 Clptm1 56457 MGI:1927155 0.60750599 Zfp251 71591 MGI:1918841 0.59531902 Zfr 22763 MGI:1341890 0.58444468 Zyg11b 414872 MGI:2685277 0.58213566 Fem1b 14155 MGI:1335087 0.57934586 Ccar2 219158 MGI:2444228 0.57925698 Strip1 229707 MGI:2443884 0.57489235 Fbxl19 233902 MGI:3039600 0.57303354 Stat3 20848 MGI:103038 0.5451765 Zfp507 668501 MGI:1916378 0.53891085 Pcif1 20747 MGI:1343085 0.53578374 Zfp397 69256 MGI:1916506 0.52955635 Dgkd 110524 MGI:102918 0.52493089 Aph1b 68318 MGI:1915568 0.51820473 Fbxo21 231670 MGI:1924223 0.4931736 Mief1 239555 MGI:2146020 0.46860915 Slc12a9 83704 MGI:1933532 0.45040482 Smarcd1 83797 MGI:1933623 0.4273829 Ncam1 17967 MGI:97281 0.41490316 Glyr1 74022 MGI:1921272 -0.3701031 Ppp1r9b 217124 MGI:2387581 -0.3850932 Ndrg3 29812 MGI:1352499 -0.4028579 Smarcc2 68094 MGI:1915344 -0.4154284 Csnk1g2 103236 MGI:1920014 -0.4187799 Morc3 338467 MGI:2136841 -0.429207 Zc3h7b 20286 MGI:1328310 -0.4826785 Psenen 66340 MGI:1913590 -0.4826793 Ppp2r5b 225849 MGI:2388480 -0.4904911 Rasa3 19414 MGI:1197013 -0.4932761 Uba1 22201 MGI:98890 -0.5119883 Clstn1 65945 MGI:1929895 -0.5175257 Zbed4 223773 MGI:2682302 -0.5388481 Pigt 78928 MGI:1926178 -0.5398718 Isg20l2 229504 MGI:2140076 -0.5452989 Scap 235623 MGI:2135958 -0.5559367 Ufc1 66155 MGI:1913405 -0.5631484 Ndst1 15531 MGI:104719 -0.5684692 Ddx39b 53817 MGI:99240 -0.5689468 Nelfb 58202 MGI:1931035 -0.5749906 Rnf216 108086 MGI:1344349 -0.5755504 Zfp740 68744 MGI:1915994 -0.57826 2610008E11Rik 72128 MGI:1919378 -0.5796226 Tmem43 74122 MGI:1921372 -0.5827396 Gdi1 14567 MGI:99846 -0.5867463 Rapgef2 76089 MGI:2659071 -0.5995289 Zfp646 233905 MGI:3665412 -0.6077243 Dus3l 224907 MGI:2147092 -0.6188657 Zfp282 101095 MGI:2141413 -0.6216216 Cyb5r4 266690 MGI:2386848 -0.6224783 Usp11 236733 MGI:2384312 -0.6233661 Zfp84 74352 MGI:107780 -0.6316447 Rnf41 67588 MGI:1914838 -0.6337599 9030025P20Rik 100041574 MGI:3583895 -0.6410081 Zfp334 74614 MGI:1921864 -0.6441608 Klhl17 231003 MGI:2678948 -0.648146 Mpi 110119 MGI:97075 -0.6505393 Zbtb9 474156 MGI:1918022 -0.6521818 Cbx6 494448 MGI:3512628 -0.6566423 Snrk 20623 MGI:108104 -0.6643931 Zfp68 24135 MGI:1344427 -0.6658638 Taf8 63856 MGI:1926879 -0.667481 Cd99l2 171486 MGI:2177151 -0.671001 Fibp 58249 MGI:1926233 -0.6727665 Clcn6 26372 MGI:1347049 -0.6802038 Ss18l1 269397 MGI:2444061 -0.6862934 Adcy5 224129 MGI:99673 -0.689292 Sec14l1 74136 MGI:1921386 -0.6934578 Fbxo46 243867 MGI:2444918 -0.69898 Trim27 19720 MGI:97904 -0.7006383 Cdk10 234854 MGI:2448549 -0.7071591 Zfp866 330788 MGI:3584369 -0.7120329 Myh9 17886 MGI:107717 -0.7131523 Vps37c 107305 MGI:2147661 -0.7163983 Pcnp 76302 MGI:1923552 -0.7224557 Evi5l 213027 MGI:2442167 -0.7274767 Zfp763 73451 MGI:1920701 -0.7309804 Oxa1l 69089 MGI:1916339 -0.7378588 Jrkl 77532 MGI:1924782 -0.7424533 Pum1 80912 MGI:1931749 -0.74298 Poldip3 73826 MGI:1921076 -0.7440746 2610021A01Rik 668572 MGI:1922662 -0.7480472 Ppm1l 242083 MGI:2139740 -0.7582897 Mus81 71711 MGI:1918961 -0.7670493 Cry1 12952 MGI:1270841 -0.7699777 Itch 16396 MGI:1202301 -0.773411 Psmb5 19173 MGI:1194513 -0.7868827 Pik3r2 18709 MGI:1098772 -0.7872428 1110051M20Rik 228356 MGI:1915079 -0.7914304 Ppm1e 320472 MGI:2444096 -0.7968213 Eef1a1 13627 MGI:1096881 -0.7997194 Zfp532 328977 MGI:3036282 -0.8055852 Btbd7 238386 MGI:1917858 -0.8096305 Nat8l 269642 MGI:2447776 -0.8176364 Zfp53 24132 MGI:99200 -0.8181796 Tsc22d4 78829 MGI:1926079 -0.8262231 Cdkn1b 12576 MGI:104565 -0.8263503 Gm3435 100041621 MGI:3810125 -0.8266414 Foxo3 56484 MGI:1890081 -0.83232 Zfp329 67230 MGI:1921283 -0.8326047 Zfp141 434178 MGI:3584269 -0.8417763 Tceanc2 66526 MGI:1913776 -0.8496217 Mllt1 64144 MGI:1927238 -0.8571138 Zfp955a 77652 MGI:4834570 -0.8580846 3-Sep No associated gene-0.8658716 Zfp958 233987 MGI:2385298 -0.8748932 Vta1 66201 MGI:1913451 -0.8819629 Dnmt3a 13435 MGI:1261827 -0.8857676 Ppil2 106369 MGI:1913303 -0.8876559 Zfp229 381067 MGI:2679295 -0.8915501 Mvb12b 72543 MGI:1919793 -0.8943496 Rnf169 108937 MGI:1920257 -0.8948961 Csrnp3 77771 MGI:1925021 -0.9028071 Zfp37 22696 MGI:99181 -0.9102777 Zbtb8os 67106 MGI:1914356 -0.9104964 Trim28 21849 MGI:109274 -0.9201045 Emc10 69683 MGI:1916933 -0.9211535 Prkcb 18751 MGI:97596 -0.9243015 Zfp235 56525 MGI:1929117 -0.9320772 Igsf11 207683 MGI:2388477 -0.9359047 Klf10 21847 MGI:1101353 -0.9411316 Kif3c 16570 MGI:107979 -0.9437486 Zfp799 240064 MGI:2443934 -0.9456162 Lrp3 435965 MGI:3584516 -0.9481446 Mcu 215999 MGI:3026965 -0.9628098 Mlst8 56716 MGI:1929514 -0.9636864 Spata2 263876 MGI:2146885 -0.9640324 Actb 11461 MGI:87904 -0.9657382 Safb 224903 MGI:2146974 -0.9694096 Tmem198 319998 MGI:2443133 -0.9724585 Dynll1 56455 MGI:1861457 -0.9731846 Zbtb40 230848 MGI:2682254 -0.9787595 N4bp2l2 381695 MGI:2687207 -0.9828318 Zfp592 233410 MGI:2443541 -0.9828426 1700021K19Rik 100502698 MGI:1915160 -0.9847144 Cpt1c 78070 MGI:2446526 -1.0032272 Bag6 224727 MGI:1919439 -1.0053085 Gprasp1 67298 MGI:1917418 -1.010021 Hspa8 15481 MGI:105384 -1.0108576 Cnnm4 94220 MGI:2151060 -1.0133738 Csnk1e 27373 MGI:1351660 -1.0163847 Zfx 22764 MGI:99211 -1.0167132 Polk 27015 MGI:1349767 -1.0174453 Zfp266 77519 MGI:1924769 -1.020329 Dpf2 19708 MGI:109529 -1.0220231 Purg 75029 MGI:1922279 -1.029226 Cul2 71745 MGI:1918995 -1.0306211 Trmt44 78890 MGI:1926140 -1.0309857 Bahd1 228536 MGI:2139371 -1.041082 Zbtb46 72147 MGI:1919397 -1.0418964 Zswim5 74464 MGI:1921714 -1.0448187 Zfp236 329002 MGI:1926950 -1.047709 Zfyve28 231125 MGI:2684992 -1.0530468 Ube2i 22196 MGI:107365 -1.0571148 Sphk2 56632 MGI:1861380 -1.0577061 Tmod2 50876 MGI:1355335 -1.0594815 Evl 14026 MGI:1194884 -1.0722289 Mta1 116870 MGI:2150037 -1.0810468 Lrp4 53419 MGI:1349451 -1.0991216 Ncoa3 17979 MGI:1276535 -1.1032045 Ehmt2 110147 MGI:2148922 -1.1061702 Galnt1 14423 MGI:894693 -1.1089574 Rbm5 83486 MGI:1933204 -1.1136406 Hspbap1 66667 MGI:1913917 -1.1257039 Hip1 215114 MGI:1099804 -1.1261763 Map3k12 26404 MGI:1346881 -1.1347243 A830010M20Rik231570 MGI:2445097 -1.1472932 Iqce 74239 MGI:1921489 -1.149575 Dbndd2 52840 MGI:106562 -1.1522971 Scg3 20255 MGI:103032 -1.156436 Ldoc1l 223732 MGI:2675858 -1.1579517 Nat6 56441 MGI:1888902 -1.1621843 Pou6f1 19009 MGI:102935 -1.1627182 Fam102b 329739 MGI:3036259 -1.1631187 Akt2 11652 MGI:104874 -1.1638089 Mapk8ip3 30957 MGI:1353598 -1.1800719 Smox 228608 MGI:2445356 -1.1823199 Dyrk1a 13548 MGI:1330299 -1.1869113 Gria2 14800 MGI:95809 -1.1908927 Spats2l 67198 MGI:1914448 -1.1957827 Zfp758 224598 MGI:2385044 -1.1957877 Dpagt1 13478 MGI:1196396 -1.2014845 Tnk2 51789 MGI:1858308 -1.2032109 Syt11 229521 MGI:1859547 -1.2037967 Cnot3 232791 MGI:2385261 -1.2055052 Dennd4c 329877 MGI:1914769 -1.2184771 Tecpr2 104859 MGI:2144865 -1.2270205 Pgpep1 66522 MGI:1913772 -1.2298686 Cdk2ap1 13445 MGI:1202069 -1.2313051 Rcc2 108911 MGI:1919784 -1.2322525 Trp53inp1 60599 MGI:1926609 -1.2354572 Hist2h2be 319190 MGI:2448415 -1.2377726 Ntrk2 18212 MGI:97384 -1.2417467 Bhlhe40 20893 MGI:1097714 -1.257773 Tgds 76355 MGI:1923605 -1.2617863 Ampd2 109674 MGI:88016 -1.2773835 Klc1 16593 MGI:107978 -1.2900515 Anks1 224650 MGI:2446180 -1.2926441 Dpysl4 26757 MGI:1349764 -1.3004057 BC004004 80748 MGI:2136782 -1.3033638 Rps2 16898 MGI:105110 -1.3102283 Ccng1 12450 MGI:102890 -1.3284296 Klhl29 208439 MGI:2683857 -1.3428885 Rab6b 270192 MGI:107283 -1.3465743 Grik3 14807 MGI:95816 -1.3481915 Apba2 11784 MGI:1261791 -1.3572455 Tdrd3 219249 MGI:2444023 -1.3577412 Tmem178b 434008 MGI:3647581 -1.3668008 Eif4g1 208643 MGI:2384784 -1.3710116 Spef1 70997 MGI:3513546 -1.375754 Lphn1 330814 MGI:1929461 -1.3815415 Src 20779 MGI:98397 -1.394131 Rsbn1 229675 MGI:2444993 -1.4025368 Ralgds 19730 MGI:107485 -1.4040088 Cdan1 68968 MGI:1916218 -1.4048249 Stk11 20869 MGI:1341870 -1.4060847 Fam213b 66469 MGI:1913719 -1.4119976 Gm15459 727711 MGI:3705702 -1.4123432 Pcdhb2 93873 MGI:2136735 -1.4139409 Clca1 12722 MGI:1316732 -1.4234444 Rab6a 19346 MGI:894313 -1.4410169 Inppl1 16332 MGI:1333787 -1.4419688 Rps6ka5 73086 MGI:1920336 -1.4455651 Tagap1 380608 MGI:1919786 -1.4503232 Cic 71722 MGI:1918972 -1.4509272 Chst2 54371 MGI:1891160 -1.4643947 Rgl1 19731 MGI:107484 -1.4668189 Araf 11836 MGI:88065 -1.4680906 Haghl 68977 MGI:1919877 -1.4764608 Casp7 12369 MGI:109383 -1.4803207 Csmd1 94109 MGI:2137383 -1.4809864 Gnptg 214505 MGI:2147006 -1.4811783 Prepl 213760 MGI:2441932 -1.4839478 Atat1 73242 MGI:1913869 -1.4849477 Ppig 228005 MGI:2445173 -1.4890885 Exog 208194 MGI:2143333 -1.4910843 3110035E14Rik 76982 MGI:1924232 -1.4971902 Lpin1 14245 MGI:1891340 -1.4983875 Katnal1 231912 MGI:2387638 -1.4999215 Ubtd1 226122 MGI:2385092 -1.4999224 Kdm5b 75605 MGI:1922855 -1.5096914 Lsm14b 241846 MGI:3040677 -1.5226115 Zfp523 224656 MGI:2687278 -1.5269835 Cdc23 52563 MGI:1098815 -1.5337682 Poglut1 224143 MGI:2444232 -1.538023 Gdpd5 233552 MGI:2686926 -1.5393684 Chd3 216848 MGI:1344395 -1.547174 1700012B15Rik 74173 MGI:1921423 -1.5512558 Actg1 11465 MGI:87906 -1.5546795 Gpaa1 14731 MGI:1202392 -1.5591747 Zfp644 52397 MGI:1277212 -1.564931 Trp53i11 277414 MGI:2670995 -1.5698756 Slc19a2 116914 MGI:1928761 -1.5878132 Fgfr1op2 67529 MGI:1914779 -1.6049042 Sema4g 26456 MGI:1347047 -1.6092844 Nxph1 18231 MGI:107492 -1.6113926 Aen 68048 MGI:1915298 -1.617075 Gm14306 545490 MGI:3615331 -1.6258449 Stat2 20847 MGI:103039 -1.6330905 Brd1 223770 MGI:1924161 -1.6347466 Tubgcp3 259279 MGI:2183752 -1.6353503 Spry2 24064 MGI:1345138 -1.6530091 Tshz1 110796 MGI:1346031 -1.6722997 Dlg3 53310 MGI:1888986 -1.6736079 Slc6a8 102857 MGI:2147834 -1.6806181 Kdm4c 76804 MGI:1924054 -1.6927639 Cd81 12520 MGI:1096398 -1.6930991 Glis2 83396 MGI:1932535 -1.7128678 2310058D17Rik 75694 MGI:1922944 -1.7333398 Ash2l 23808 MGI:1344416 -1.7364082 Dbn1 56320 MGI:1931838 -1.7388524 Med14 26896 MGI:1349442 -1.7434282 Elmo1 140580 MGI:2153044 -1.7545925 Ano3 228432 MGI:3613666 -1.7567277 Col4a1 12826 MGI:88454 -1.7599135 Arfrp1 76688 MGI:1923938 -1.7669951 Mbp 17196 MGI:96925 -1.7709371 Miat 330166 MGI:2444886 -1.7788165 Ing4 28019 MGI:107307 -1.7794569 Pus3 67049 MGI:1914299 -1.7930074 Pdcl 67466 MGI:1914716 -1.7930474 Nol9 74035 MGI:1921285 -1.8137766 Banp 53325 MGI:1889023 -1.8165848 Ptprn2 19276 MGI:107418 -1.8274139 Rnf10 50849 MGI:1859162 -1.8274755 Fam134c 67998 MGI:1915248 -1.8385567 Asic1 11419 MGI:1194915 -1.8397088 Slc2a6 227659 MGI:2443286 -1.846947 Btbd2 208198 MGI:1933831 -1.8483476 Carkd 69225 MGI:1913353 -1.8514518 Fam73b 108958 MGI:1922035 -1.8550142 Dbi 13167 MGI:94865 -1.8618991 Npdc1 18146 MGI:1099802 -1.8788326 Smarca4 20586 MGI:88192 -1.8805955 Napg 108123 MGI:104561 -1.8862909 Meis2 17536 MGI:108564 -1.8979544 Pacs2 217893 MGI:1924399 -1.9087553 Slitrk2 245450 MGI:2679449 -1.9146461 Ehd3 57440 MGI:1928900 -1.9198333 Zkscan5 22757 MGI:107533 -1.9236587 Psmd8 57296 MGI:1888669 -1.9264655 Pisd 320951 MGI:2445114 -1.9318771 AA986860 212439 MGI:2138143 -1.9329153 Slc25a29 214663 MGI:2444911 -1.9503239 Cep170b 217882 MGI:2145043 -1.9665922 Pcdh1 75599 MGI:104692 -1.969526 Tab2 68652 MGI:1915902 -1.975657 Sesn2 230784 MGI:2651874 -1.9759369 Tcf12 21406 MGI:101877 -1.9815095 6530402F18Rik 76220 MGI:1923470 -1.9978612 Zer1 227693 MGI:2442511 -2.0025289 Furin 18550 MGI:97513 -2.0071892 Brsk2 75770 MGI:1923020 -2.0117907 Mars 216443 MGI:1345633 -2.0198957 Hspa5 14828 MGI:95835 -2.0288939 Gnb1 14688 MGI:95781 -2.0328207 Hnrnph1 59013 MGI:1891925 -2.0336514 Creg2 263764 MGI:1928333 -2.0420528 Grm5 108071 MGI:1351342 -2.0475606 Fahd2a 68126 MGI:1915376 -2.0504214 Arl14ep 212772 MGI:1926020 -2.0576279 Traf3 22031 MGI:108041 -2.065124 Gpr153 100129 MGI:1916157 -2.0799453 Prpf40b 54614 MGI:1925583 -2.1347072 Cdkn1a 12575 MGI:104556 -2.138118 Gpr123 52389 MGI:1277167 -2.1418272 Rbak 57782 MGI:1927369 -2.1551215 Zbtb7b 22724 MGI:102755 -2.1570082 Hnrnpl 15388 MGI:104816 -2.1629209 Jmjd8 72106 MGI:1919356 -2.1751632 Zfp563 240068 MGI:2677168 -2.1809356 Zfp747 269997 MGI:2443581 -2.1915416 Mdm2 17246 MGI:96952 -2.1952575 Usp2 53376 MGI:1858178 -2.1976509 Sorcs2 81840 MGI:1932289 -2.2001579 Cars 27267 MGI:1351477 -2.2013235 Gak 231580 MGI:2442153 -2.2093276 Ube2l3 22195 MGI:109240 -2.2191008 Nfib 18028 MGI:103188 -2.2270088 N4bp2l1 100637 MGI:2140872 -2.2281174 Tsc22d3 14605 MGI:1196284 -2.2440245 Slc25a4 11739 MGI:1353495 -2.2447269 Eif4g3 230861 MGI:1923935 -2.2539998 Gpsm1 67839 MGI:1915089 -2.2543201 Mthfr 17769 MGI:106639 -2.2607939 Rad52 19365 MGI:101949 -2.269034 Spag9 70834 MGI:1918084 -2.2706712 Prmt1 15469 MGI:107846 -2.2726401 Lrig1 16206 MGI:107935 -2.2825419 Tacc1 320165 MGI:2443510 -2.2894847 Tmsb4x 19241 MGI:99510 -2.3092408 Smarcal1 54380 MGI:1859183 -2.3152064 Vangl2 93840 MGI:2135272 -2.3155173 Sfpq 71514 MGI:1918764 -2.3155281 C1qtnf1 56745 MGI:1919254 -2.3162984 Nkain4 58237 MGI:1915372 -2.3204761 2700012I20Rik 72588 MGI:1919838 -2.3257382 Gm10259 100039592 MGI:3704211 -2.3292066 Cnot2 72068 MGI:1919318 -2.3350898 Azi2 27215 MGI:1351332 -2.34695 Gorasp2 70231 MGI:2135962 -2.3552114 Tspyl5 239364 MGI:2442458 -2.3560857 Tmem180 75146 MGI:1922396 -2.3722864 Celsr3 107934 MGI:1858236 -2.3745143 Rab3b 69908 MGI:1917158 -2.3882651 Rnf208 68846 MGI:1916096 -2.3903181 Hnrnpf 98758 MGI:2138741 -2.4114091 Sirt7 209011 MGI:2385849 -2.4221101 Fam102a 98952 MGI:2138935 -2.4241004 Gabpb1 14391 MGI:95611 -2.4271543 Txndc15 69672 MGI:1916922 -2.4294252 Tmem223 66836 MGI:1914086 -2.4325994 Socs2 216233 MGI:1201787 -2.4332654 Man2c1 73744 MGI:1920994 -2.4338237 Bcas1 76960 MGI:1924210 -2.437525 Lage3 66192 MGI:1913442 -2.441607 Dfna5 54722 MGI:1889850 -2.4585403 Stard10 56018 MGI:1860093 -2.4630813 Aars 234734 MGI:2384560 -2.4675283 Dpf1 29861 MGI:1352748 -2.4717756 Hmgcr 15357 MGI:96159 -2.4723309 Set 56086 MGI:1860267 -2.4756733 Pank4 269614 MGI:2387466 -2.4817211 Bcl2l1 12048 MGI:88139 -2.4859991 Sgsm3 105835 MGI:1916329 -2.4961526 Neat1 66961 MGI:1914211 -2.4966241 Vezt 215008 MGI:2143698 -2.4966588 Celf3 78784 MGI:1926034 -2.5189379 BC029214 227622 MGI:2442831 -2.5279479 Epb4.1l3 13823 MGI:103008 -2.5596887 Plekha6 240753 MGI:2388662 -2.5657147 Fbrsl1 381668 MGI:1920907 -2.5841979 Armcx1 78248 MGI:1925498 -2.594974 Nfx1 74164 MGI:1921414 -2.634808 Amotl2 56332 MGI:1929286 -2.649228 Nckap5 210356 MGI:2686394 -2.6560833 Chac1 69065 MGI:1916315 -2.6788158 Odf2 18286 MGI:1098824 -2.6845706 Arhgap23 58996 MGI:3697726 -2.6846914 Gcn1l1 231659 MGI:2444248 -2.6894387 Abhd16a 193742 MGI:99476 -2.6975166 Ddr2 18214 MGI:1345277 -2.7198112 Dynlrb1 67068 MGI:1914318 -2.7309797 Bnip2 12175 MGI:109327 -2.7321126 Zfp709 236193 MGI:2384299 -2.7369704 2610507I01Rik 72203 MGI:1919453 -2.74577 Tle3 21887 MGI:104634 -2.7480713 RP24-390G17.1 No associated gene-2.7486309 Nfe2l1 18023 MGI:99421 -2.7526223 Hnrnpc 15381 MGI:107795 -2.7531106 Acot7 70025 MGI:1917275 -2.755122 Zfp287 170740 MGI:2176561 -2.7706512 Prrc2b 227723 MGI:1923304 -2.7727694 Spns2 216892 MGI:2384936 -2.776995 Abcc5 27416 MGI:1351644 -2.7790667 Gpd2 14571 MGI:99778 -2.7949838 Slc44a1 100434 MGI:2140592 -2.8088293 Mapkapk3 102626 MGI:2143163 -2.818282 Nkiras2 71966 MGI:1919216 -2.8200213 Clcn3 12725 MGI:103555 -2.8314188 Gm20482 102632136 MGI:5141947 -2.8378499 Pxk 218699 MGI:1289230 -2.8426559 Bfsp2 107993 MGI:1333828 -2.8443999 Gtf2h4 14885 MGI:1338799 -2.8544026 Lmtk3 381983 MGI:3039582 -2.859489 Gstk1 76263 MGI:1923513 -2.8659985 Cdc14a 229776 MGI:2442676 -2.8724378 Ankrd13c 433667 MGI:2139746 -2.8758042 Pdrg1 68559 MGI:1915809 -2.8764925 9130019O22Rik 78921 MGI:1926171 -2.8908705 Trf 22041 MGI:98821 -2.9017862 Zbtb25 109929 MGI:99197 -2.9036694 Ntng2 171171 MGI:2159341 -2.9048706 Cln3 12752 MGI:107537 -2.9062362 Enpp6 320981 MGI:2445171 -2.91808 Atp6v1g2 66237 MGI:1913487 -2.9226987 Hmgb1 15289 MGI:96113 -2.9302455 Trp53cor1 100504267 MGI:3801771 -2.9318826 Ncaph 215387 MGI:2444777 -2.9412959 Pih1d1 68845 MGI:1916095 -2.9629835 Usp21 30941 MGI:1353665 -2.9673142 Sumo2 170930 MGI:2158813 -2.9778552 Tfe3 209446 MGI:98511 -2.9820574 Gm9625 674597 MGI:3780033 -2.9824253 Dpysl5 65254 MGI:1929772 -2.9864387 Gm10263 100042864 MGI:3642825 -2.9920082 Pcdha2 353234 MGI:2681880 -2.9985891 Lrrfip1 16978 MGI:1342770 -3.0018651 Cacul1 78832 MGI:1926082 -3.0108583 Rian 75745 MGI:1922995 -3.0131396 Plce1 74055 MGI:1921305 -3.0131632 Gm8730 667618 MGI:3644565 -3.0571015 Abhd14a 68644 MGI:1915894 -3.0662317 Rpl29 19944 MGI:99687 -3.0670506 Ralgapb 228850 MGI:2444531 -3.0862428 Kcnc1 16502 MGI:96667 -3.0940933 5430405H02Rik 74487 MGI:1921737 -3.1079092 Tmem100 67888 MGI:1915138 -3.1142697 Fam212b 109050 MGI:1923497 -3.1201803 Eya3 14050 MGI:109339 -3.1211151 Otub1 107260 MGI:2147616 -3.1262779 A230056P14Rik 320845 MGI:2444856 -3.1504376 Wnk4 69847 MGI:1917097 -3.1506104 Cuedc2 67116 MGI:1914366 -3.1729398 C130071C03Rik 320203 MGI:2443574 -3.2005227 Tm9sf2 68059 MGI:1915309 -3.2190464 Fam53b 77938 MGI:1925188 -3.223421 Tbc1d1 57915 MGI:1889508 -3.23013 Trim11 94091 MGI:2137355 -3.2476734 Gm13835 100038973 MGI:3650921 -3.2512322 Ubc 22190 MGI:98889 -3.2644723 Ndufc2 68197 MGI:1344370 -3.2648852 Eda2r 245527 MGI:2442860 -3.2763617 Vstm2b 58188 MGI:1914525 -3.2814235 Gusb 110006 MGI:95872 -3.2904701 Ak1 11636 MGI:87977 -3.2994047 Fam73a 215708 MGI:1924567 -3.3039835 Rnf157 217340 MGI:2442484 -3.3097781 Hmces 232210 MGI:1914053 -3.3316658 Rpl34-ps1 619547 MGI:3704270 -3.3328074 Gdpd3 68616 MGI:1915866 -3.3525574 Tshz3 243931 MGI:2442819 -3.3528136 Igsf21 230868 MGI:2681842 -3.3568048 1110034G24Rik 73747 MGI:1920997 -3.3611368 Gm6166 101056162 MGI:3645893 -3.369352 Tuba1a 22142 MGI:98869 -3.3894447 Ech1 51798 MGI:1858208 -3.4160583 Zfp882 382019 MGI:3642748 -3.4256953 Csmd2 329942 MGI:2386401 -3.4315901 -3.4319065 Table S1: Thap1 +/+ Vs Thap1 -/- DEG - DIV 2 Symbol Entrez Gene ID MGI Gene/Marker ID log2FoldChange.2D Anxa6 11749 MGI:88255 5.98829443 Gm15093 100039890 MGI:3712496 5.5732323 Anxa6 11749 MGI:88255 5.326444457 Ott 18422 MGI:107573 5.243756427 Gm15085 100039934 MGI:3712210 5.243756427 Abca6 76184 MGI:1923434 5.235286897 Scarf1 380713 MGI:2449455 4.934619329 Stx3 20908 MGI:103077 4.795800678 Mgat1 17308 MGI:96973 4.717931074 Ramp2 54409 MGI:1859650 4.677798312 Pik3r5 320207 MGI:2443588 4.632978586 Fuca2 66848 MGI:1914098 4.581032841 Efcab1 66793 MGI:1914043 4.557905736 St3gal6 54613 MGI:1888707 4.540883149 Gm11520 102640811 MGI:3650534 4.432601059 Gm15109 100039545 MGI:3705842 4.415981715 Emp3 13732 MGI:1098729 4.323929856 Cast 12380 MGI:1098236 4.279032596 Chst5 56773 MGI:1931825 4.205738771 Il33 77125 MGI:1924375 4.169040781 Plin2 11520 MGI:87920 4.132706771 Ttc39aos1 102635290 MGI:3651956 4.070689349 Kcnip2 80906 MGI:2135916 3.986944765 Vamp5 53620 MGI:1858622 3.972793233 Slc38a6 625098 MGI:3648156 3.947943202 Scarf1 380713 MGI:2449455 3.910008199 Gm11868 667251 MGI:3650507 3.905669184 Gm10439 382243 MGI:3710525 3.903390542 St6gal1 20440 MGI:108470 3.900558701 Il6ra 16194 MGI:105304 3.858239744 Il33 77125 MGI:1924375 3.828458969 Zfp800 627049 MGI:1889334 3.818788374 A930017M01Rik239410 MGI:2685151 3.802057105 Mpg 268395 MGI:97073 3.801812336 Ddx4 13206 MGI:102670 3.78563512 Pyroxd2 74580 MGI:1921830 3.781551589 Adcy3 104111 MGI:99675 3.763235015 Fam114a1 68303 MGI:1915553 3.699514163 Prdm5 70779 MGI:1918029 3.686102167 Ramp2 54409 MGI:1859650 3.641226801 Hotairm1 105242658 MGI:3705155 3.621465651 Aebp1 11568 MGI:1197012 3.61672107 Luzp4 434865 MGI:3708816 3.610712361 Fndc3c1 333564 MGI:2685630 3.602198036 Car6 12353 MGI:1333786 3.598622345 Zmynd8 228880 MGI:1918025 3.594275899 Dzip1l 72507 MGI:1919757 3.580348235 Rsad2 58185 MGI:1929628 3.567242676 Mfge8 17304 MGI:102768 3.547556396 Pter 19212 MGI:107372 3.520055064 Anxa6 11749 MGI:88255 3.502093984 Pcolce2 76477 MGI:1923727 3.491095167 Plekha2 83436 MGI:1928144 3.475274468 Tspan11 68498 MGI:1915748 3.4527768 Tsr1 104662 MGI:2144566 3.43959904 Ddx4 13206 MGI:102670 3.421683258 B3galt5 93961 MGI:2136878 3.416301234 Mdm2 17246 MGI:96952 3.395327497 Gabrb2 14401 MGI:95620 3.373676566 Gdnf 14573 MGI:107430 3.336155314 Atp6v0a4 140494 MGI:2153480 3.331332392 Adamts14 237360 MGI:2179942 3.328911097 Syt4 20983 MGI:101759 3.295388182 Mmp11 17385 MGI:97008 3.26456963 Mmp11 17385 MGI:97008 3.251322464 Serpinb8 20725 MGI:894657 3.243044152 Pax9 18511 MGI:97493 3.239394752 Pter 19212 MGI:107372 3.22773547 Gm15091 382244 MGI:3712222 3.22125683 Aebp1 11568 MGI:1197012 3.184348914 Atp6v0a4 140494 MGI:2153480 3.165810753 Celf4 108013 MGI:1932407 3.161123599 Serhl 68607 MGI:1890404 3.15098215 Akt1s1 67605 MGI:1914855 3.117679106 Il10rb 16155 MGI:109380 3.112710399 Mical1 171580 MGI:2385847 3.108380885 Cyb5d2 192986 MGI:2684848 3.103831308 Zfp748 212276 MGI:1916455 3.101911117 Septin9 53860 MGI:1858222 3.099847363 Emp3 13732 MGI:1098729 3.086080244 Mapt 17762 MGI:97180 3.082017703 Depdc1a 76131 MGI:1923381 3.078196626 Gm15080 666184 MGI:3712217 3.075959424 Cpeb1 12877 MGI:108442 3.061332709 Fam174b 100038347 MGI:3698178 3.055313874 Pgbd5 209966 MGI:2429955 3.047151489 Cpeb1 12877 MGI:108442 3.044034623 Hs6st2 50786 MGI:1354959 3.043293495 Lmx1b 16917 MGI:1100513 3.026555163 Rasgef1a 70727 MGI:1917977 3.010227883 Ablim1 226251 MGI:1194500 3.00732636 Penk 18619 MGI:104629 2.956639454 Morc4 75746 MGI:1922996 2.952916269 Rnaseh2a 69724 MGI:1916974 2.94182639 Vdac2 22334 MGI:106915 2.926472344 Tgfbi 21810 MGI:99959 2.921214666 Cdc42ep5 58804 MGI:1929745 2.905226425 Sfmbt2 353282 MGI:2447794 2.902417884 Adcy3 104111 MGI:99675 2.896707176 Celf4 108013 MGI:1932407 2.896494247 Madd 228355 MGI:2444672 2.888892861 Mapt 17762 MGI:97180 2.881476719 Zfp429 72807 MGI:1920057 2.869113981 B3galt5 93961 MGI:2136878 2.867116635 Sparc 20692 MGI:98373 2.866056779 Morc4 75746 MGI:1922996 2.864812746 Ttc39a 230603 MGI:2444350 2.852627629 Rgcc 66214 MGI:1913464 2.850403081 Tenm2 23964 MGI:1345184 2.838078987 Flna 192176 MGI:95556 2.804003144 Lncpint 232685 MGI:2673128 2.789585936 Plch1 269437 MGI:2683547 2.789210116 Mxra8 74761 MGI:1922011 2.788426378 Npr3 18162 MGI:97373 2.787054484 Col16a1 107581 MGI:1095396 2.778831614 Ramp2 54409 MGI:1859650 2.778506824 Nid1 18073 MGI:97342 2.776450905 Col27a1 373864 MGI:2672118 2.772400214 Gm15950 100416121 MGI:3802178 2.770117187 Tnfrsf12a 27279 MGI:1351484 2.764018996 Ptgds 19215 MGI:99261 2.762126353 Abr 109934 MGI:107771 2.75548198 Sptb 20741 MGI:98387 2.747702686 Cdk1 12534 MGI:88351 2.7434996 B3galt5 93961 MGI:2136878 2.73455526 Vmp1 75909 MGI:1923159 2.733728706 Cdh18 320865 MGI:1344366 2.716220218 Eif3s6-ps2 16343 MGI:103204 2.699489495 Sparc 20692 MGI:98373 2.695028832 Sema7a 20361 MGI:1306826 2.691233143 No associated gene 2.681868067 Septin9 53860 MGI:1858222 2.646379094 Gm14150 100043840 MGI:3651006 2.644881713 Ppp1r9a 243725 MGI:2442401 2.64256962 Kcnip1 70357 MGI:1917607 2.641281663 Prokr1 58182 MGI:1929676 2.635248707 A930017M01Rik239410 MGI:2685151 2.622116434 Ddn 13199 MGI:108101 2.617529521 Gpbp1l1 77110 MGI:1924360 2.607591439 Hs6st2 50786 MGI:1354959 2.58621609 Grb10 14783 MGI:103232 2.5701944 Steap3 68428 MGI:1915678 2.564464112 Lrrc1 214345 MGI:2442313 2.563829623 Gm12534 MGI:3650303 2.551200369 Fggy 75578 MGI:1922828 2.550836481 Zfp991 666532 MGI:3701604 2.548368509 Mpg 268395 MGI:97073 2.546981797 Runx1t1 12395 MGI:104793 2.534037893 Slc39a14 213053 MGI:2384851 2.531507364 No associated gene 2.530226764 Tuba1c 22146 MGI:1095409 2.524189645 Stat5a 20850 MGI:103036 2.514026443 Tk1 21877 MGI:98763 2.493745917 Ucp2 22228 MGI:109354 2.486197713 Copz2 56358 MGI:1929008 2.478805363 Lrrc75a 192976 MGI:2682293 2.475178211 Zfp536 243937 MGI:1926102 2.449285706 Col18a1 12822 MGI:88451 2.44856275 Mapt 17762 MGI:97180 2.443751882 Gpd1 14555 MGI:95679 2.428464433 Tmod1 21916 MGI:98775 2.415042645 Cd302 66205 MGI:1913455 2.398986975 Cyp4f17 208285 MGI:3646233 2.391311477 Eps8 13860 MGI:104684 2.376118143 Pdzd2 68070 MGI:1922394 2.373099997 Lmcd1 30937 MGI:1353635 2.360310121 Gm20646 MGI:5313093 2.330985362 Ptgds 19215 MGI:99261 2.324019024 Hebp1 15199 MGI:1333880 2.312307714 Ralgps2 78255 MGI:1925505 2.307767807 Birc5 11799 MGI:1203517 2.291670685 Maf 17132 MGI:96909 2.283964238 Tpbg 21983 MGI:1341264 2.281429115 Pls1 102502 MGI:104809 2.280717403 BC051226 407803 MGI:3039585 2.249652289 Hexa 15211 MGI:96073 2.245931001 BC106179 320099 MGI:3702726 2.244011518 Itga8 241226 MGI:109442 2.243802402 St3gal6 54613 MGI:1888707 2.242855863 Glce 93683 MGI:2136405 2.23295874 C77080 97130 MGI:2140651 2.222100455 Gas5 14455 MGI:95659 2.20542405 Dnase2a 13423 MGI:1329019 2.199146668 Gbp11 634650 MGI:3646307 2.194374693 Polm 54125 MGI:1860191 2.182074973 Msn 17698 MGI:97167 2.178375383 Rflnb 76566 MGI:1923816 2.168193785 Hmmr 15366 MGI:104667 2.166635382 Erp27 69187 MGI:1916437 2.160433496 Gm9885 791275 MGI:3641726 2.154817904 Epb41l4b 54357 MGI:1859149 2.149366152 Gemin5 216766 MGI:2449311 2.140429367 Irx5 54352 MGI:1859086 2.110571001 Mmgt2 216829 MGI:2448491 2.093731518 Ptgds 19215 MGI:99261 2.087846373 Dct 13190 MGI:102563 2.086124329 Eps8 13860 MGI:104684 2.073480493 Nek2 18005 MGI:109359 2.065719931 Wnk3 279561 MGI:2652875 2.062306276 Ube2e2 218793 MGI:2384997 2.061380889 Phka1 18679 MGI:97576 2.060219832 Gpr176 381413 MGI:2685858 2.043144906 Ttc17 74569 MGI:1921819 2.038071767 Anxa2 12306 MGI:88246 2.029494527 Ube2c 68612 MGI:1915862 2.007394323 Fn3k 63828 MGI:1926834 2.006104674 Jmjd6 107817 MGI:1858910 2.005154146 Slc39a11 69806 MGI:1917056 1.99823556 Erbb3 13867 MGI:95411 1.971821008 Phldb3 232970 MGI:3642959 1.964987196 Cmtm3 68119 MGI:2447162 1.961770852 St6gal1 20440 MGI:108470 1.960688453 Tph2 216343 MGI:2651811 1.959975119 Tmem117 320709 MGI:2444580 1.948414574 Dock2 94176 MGI:2149010 1.935281302 Pde10a 23984 MGI:1345143 1.932575511 Vav3 57257 MGI:1888518 1.927506215 Slc43a2 215113 MGI:2442746 1.925726478 Cela1 109901 MGI:95314 1.908520954 Chek2 50883 MGI:1355321 1.90520331 Tomm40l 641376 MGI:3589112 1.891896793 Septin9 53860 MGI:1858222 1.890544741 Plpp2 50784 MGI:1354945 1.878775318 Ccdc28a 215814 MGI:2443508 1.874608872 Fam117a 215512 MGI:2144564 1.864582381 Eno2 13807 MGI:95394 1.857641067 Mapk8ip3 30957 MGI:1353598 1.852228469 Pcdh8 18530 MGI:1306800 1.851916206 Haus4 219072 MGI:1261794 1.851508609 Afap1l1 106877 MGI:2147199 1.846924839 Car6 12353 MGI:1333786 1.846542535 Tmem268 230279 MGI:1913920 1.829165767 Slc39a11 69806 MGI:1917056 1.828348895 Sh3pxd2b 268396 MGI:2442062 1.823276645 Rnaseh2a 69724 MGI:1916974 1.815540063 Septin4 18952 MGI:1270156 1.808561623 Tpd52l1 21987 MGI:1298386 1.801227216 Trim11 94091 MGI:2137355 1.771555556 Npepl1 228961 MGI:2448523 1.764499821 Trim21 20821 MGI:106657 1.762345675 Commd1b MGI:5547784 1.755245687 Ubtf 21429 MGI:98512 1.746419653 Nav3 260315 MGI:2183703 1.725490148 Hlf 217082 MGI:96108 1.723559194 Fabp5 16592 MGI:101790 1.71944649 Zrsr1 22183 MGI:98885 1.71086003 Rab34 19376 MGI:104606 1.707641816 Sord 20322 MGI:98266 1.707045831 Gt(ROSA)26Sor14910 MGI:104735 1.700953836 Larp6 67557 MGI:1914807 1.694555721 Dhrs11 192970 MGI:2652816 1.691348815 Sptbn1 20742 MGI:98388 1.684899506 Snrnp35 76167 MGI:1923417 1.672756124 Arrb1 109689 MGI:99473 1.66948026 Sec14l5 665119 MGI:3616084 1.658226797 Gas5 14455 MGI:95659 1.640275473 Sgpl1 20397 MGI:1261415 1.639173025 Gm7887 666005 MGI:3648251 1.630286274 Chsy3 78923 MGI:1926173 1.629113261 Smoc1 64075 MGI:1929878 1.628932851 Sirpa 19261 MGI:108563 1.617169472 Pllp 67801 MGI:1915051 1.614954954 Ranbp17 66011 MGI:1929706 1.598778707 Rap2b 74012 MGI:1921262 1.5931414 Tmem200a 77220 MGI:1924470 1.587277914 Tgfb3 21809 MGI:98727 1.577689567 Aldh2 11669 MGI:99600 1.574688135 Aars2 224805 MGI:2681839 1.571077227 Rpl15-ps6 100039748 MGI:3642192 1.566105778 Ninj2 29862 MGI:1352751 1.564873367 Sh3tc2 225608 MGI:2444417 1.556612494 Gm10335 100039571 MGI:3641693 1.554957013 Rsph9 75564 MGI:1922814 1.539563617 Acads 11409 MGI:87868 1.538413355 Tex2 21763 MGI:102465 1.534239015 Kremen1 84035 MGI:1933988 1.531325095 Adgrg1 14766 MGI:1340051 1.528637843 Itgb3 16416 MGI:96612 1.51979653 Bche 12038 MGI:894278 1.512164835 Timp2 21858 MGI:98753 1.509806539 Cfap300 234912 MGI:3045346 1.505252575 Hemk1 69536 MGI:1916786 1.495268315 Capn7 12339 MGI:1338030 1.484755569 Ift20 55978 MGI:1915585 1.48392185 Gm13456 666531 MGI:3651389 1.478861787 Syngr1 20972 MGI:1328323 1.456317443 Ezh1 14055 MGI:1097695 1.449851867 Ppfibp1 67533 MGI:1914783 1.444959626 Oat 18242 MGI:97394 1.444838766 Dlc1 50768 MGI:1354949 1.441193318 Tbc1d8b 245638 MGI:1918101 1.432764629 Gdf11 14561 MGI:1338027 1.422511874 Amt 434437 MGI:3646700 1.417636284 Trmt1 212528 MGI:1289155 1.406142398 Crbn 58799 MGI:1913277 1.392159142 Uap1l1 227620 MGI:2443318 1.391608066 Pnpla7 241274 MGI:2385325 1.390048663 Rgs17 56533 MGI:1927469 1.374898443 Omg 18377 MGI:106586 1.363636001 Syngr1 20972 MGI:1328323 1.35151372 Nptx1 18164 MGI:107811 1.351364223 Wdr81 192652 MGI:2681828 1.339826492 Zfp820 75424 MGI:1922674 1.328949356 Kcnk1 16525 MGI:109322 1.326605772 2410006H16Rik69221 MGI:1916471 1.305908356 Ezh1 14055 MGI:1097695 1.305790599 Fmn1 14260 MGI:101815 1.302610146 Gaa 14387 MGI:95609 1.291512607 Irgm1 15944 MGI:107567 1.287926447 Gm2a 14667 MGI:95762 1.287254841 Pros1 19128 MGI:1095733 1.277498298 Tmsb15l 399591 MGI:3026988 1.276239747 Tmem35a 67564 MGI:1914814 1.26946047 Tvp23b 67510 MGI:1914760 1.268901926 Smad3 17127 MGI:1201674 1.267214949 Efs 13644 MGI:105311 1.239584807 Rragd 52187 MGI:1098604 1.224057918 Fam181b 58238 MGI:1930951 1.21961486 Sned1 208777 MGI:3045960 1.217852579 Slc26a2 13521 MGI:892977 1.217508748 Zfp286 192651 MGI:2384758 1.207496285 Pigs 276846 MGI:2687325 1.198684278 Nme4 56520 MGI:1931148 1.182958755 Rpl23a 268449 MGI:3040672 1.181751761 Rapgef1 107746 MGI:104580 1.174067778 Lta4h 16993 MGI:96836 1.169007367 Kcna1 16485 MGI:96654 1.166429598 Cntln 338349 MGI:2443104 1.154052056 Ppp2r3c 59032 MGI:1930009 1.148977503 Tom1l2 216810 MGI:2443306 1.145794165 Nuak1 77976 MGI:1925226 1.136735692 Tdrp 72148 MGI:1919398 1.124097148 Mkx 210719 MGI:2687286 1.1220897 Slc2a1 20525 MGI:95755 1.120531796 Mat2b 108645 MGI:1913667 1.10468948 Pet100 100503890 MGI:3615306 1.09750962 Cd63 12512 MGI:99529 1.095981166 Ano10 102566 MGI:2143103 1.090958169 Tsr1 104662 MGI:2144566 1.084515328 Lhpp 76429 MGI:1923679 1.084111537 Optn 71648 MGI:1918898 1.079847428 Abhd2 54608 MGI:1914344 1.069178374 Mif 17319 MGI:96982 1.068244948 Cfap410 67884 MGI:1915134 1.062665027 C1ql3 227580 MGI:2387350 1.059467991 Mprip 26936 MGI:1349438 1.03555544 Aars 234734 MGI:2384560 1.027755777 2900052L18Rik102640779 MGI:1924085 1.025035231 Robo1 19876 MGI:1274781 1.011930603 Clint1 216705 MGI:2144243 1.010290994 Rnft1 76892 MGI:1924142 1.003935111 Scamp2 24044 MGI:1346518 0.998993253 Zfp14 243906 MGI:99160 0.975429182 Rpl10-ps3 100043346 MGI:3704336 0.975407186 Zfp874a 238692 MGI:3040703 0.973666025 Hddc3 68695 MGI:1915945 0.968079161 Zbtb38 245007 MGI:2442866 0.954390818 Set 56086 MGI:1860267 0.951294431 Abcb6 74104 MGI:1921354 0.946438451 Rars 104458 MGI:1914297 0.940674478 Idh2 269951 MGI:96414 0.940483227 Sqstm1 18412 MGI:107931 0.938044921 Dhrs4 28200 MGI:90169 0.935010739 Uggt2 66435 MGI:1913685 0.921244064 Cnrip1 380686 MGI:1917505 0.919900689 Extl3 54616 MGI:1860765 0.917042337 Aatf 56321 MGI:1929608 0.912326048 Rplp0 11837 MGI:1927636 0.91032522 Rabep1 54189 MGI:1860236 0.904365199 Ipo4 75751 MGI:1923001 0.871824277 Ero1l 50527 MGI:1354385 0.862125111 Prpsap1 67763 MGI:1915013 0.856257336 Focad 230393 MGI:2676921 0.856170407 Cdk5rap3 80280 MGI:1933126 0.855819201 Trp53 22059 MGI:98834 0.845692579 Ncoa4-ps 627557 MGI:3648259 0.843220331 Trp53 22059 MGI:98834 0.842045096 Dhx40 67487 MGI:1914737 0.836759411 Pepd 18624 MGI:97542 0.8292397 Traf4 22032 MGI:1202880 0.82837859 Mpdu1 24070 MGI:1346040 0.819981886 Mettl2 52686 MGI:1289171 0.796875172 Arfgap3 66251 MGI:1913501 0.796190641 Rps2 16898 MGI:105110 0.789965239 Atp1b3 11933 MGI:107788 0.788461904 Gabrb3 14402 MGI:95621 0.775945705 Dvl2 13543 MGI:106613 0.771847345 Snap91 20616 MGI:109132 0.766204477 Man2a2 140481 MGI:2150656 0.765147495 Npm1 18148 MGI:106184 0.74912729 Mrpl12 56282 MGI:1926273 0.743760961 Xrcc5 22596 MGI:104517 0.733207207 P4hb 18453 MGI:97464 0.727121022 Tbc1d23 67581 MGI:1914831 0.714877929 Atic 108147 MGI:1351352 0.699221773 Stk24 223255 MGI:2385007 0.689470024 Eef1b2 55949 MGI:1929520 0.687194971 Gpsm2 76123 MGI:1923373 0.684954339 Tmed3 66111 MGI:1913361 0.654293498 Noc3l 57753 MGI:1932610 0.607432319 Tyw1 100929 MGI:2141161 0.604808593 Tbrg1 21376 MGI:1100877 0.603010812 Cpeb4 67579 MGI:1914829 0.602733483 Mzt1 76789 MGI:1924039 0.594513231 Mpi 110119 MGI:97075 0.555803074 Sod1 20655 MGI:98351 0.551582898 Spg11 214585 MGI:2444989 0.540031395 Tmem263 103266 MGI:2143652 0.51068675 Surf4 20932 MGI:98445 0.476170331 Elp3 74195 MGI:1921445 0.431021894 Coa5 76178 MGI:1923428 0.408532745 Ctnnb1 12387 MGI:88276 0.338714593 Zfp24 59057 MGI:1929704 -0.372175942 Tmem183a 57439 MGI:1914729 -0.411443937 Ro60 20822 MGI:106652 -0.42826572 Selenot 69227 MGI:1916477 -0.448600466 Zfp37 22696 MGI:99181 -0.472237012 Zfp397 69256 MGI:1916506 -0.483044951 Scd2 20250 MGI:98240 -0.493575844 Clstn1 65945 MGI:1929895 -0.522017689 Uba1 22201 MGI:98890 -0.561800107 Zfp799 240064 MGI:2443934 -0.579885086 Exoc4 20336 MGI:1096376 -0.586437249 Zfp157 72154 MGI:1919404 -0.606533899 Fem1b 14155 MGI:1335087 -0.638270179 Olig2 50913 MGI:1355331 -0.64295192 Lsm14b 241846 MGI:3040677 -0.651199612 Adcy5 224129 MGI:99673 -0.657876435 Cry1 12952 MGI:1270841 -0.667668791 Fibp 58249 MGI:1926233 -0.672188371 Hdac6 15185 MGI:1333752 -0.720824468 Emc10 69683 MGI:1916933 -0.724895862 Zfp87 170763 MGI:107768 -0.724979243 Pign 27392 MGI:1351629 -0.730026323 1600014C10Rik72244 MGI:1919494 -0.734246596 Tada2b 231151 MGI:3035274 -0.750867696 No associated gene -0.757083652 Tnik 665113 MGI:1916264 -0.760425516 Ppm1e 320472 MGI:2444096 -0.762633003 Pomgnt1 68273 MGI:1915523 -0.775360719 Pcdh10 18526 MGI:1338042 -0.782262022 Abcd1 11666 MGI:1349215 -0.807764978 Macroh2a2 404634 MGI:3037658 -0.814386228 Zfp780b 338354 MGI:2444764 -0.816505153 Pfkl 18641 MGI:97547 -0.817690069 Gdpd5 233552 MGI:2686926 -0.81887662 Gpr137 107173 MGI:2147529 -0.819011087 Fam49b 223601 MGI:1923520 -0.852378707 Zcchc3 67917 MGI:1915167 -0.853685625 No associated gene -0.857301003 Cdk2ap1 13445 MGI:1202069 -0.860198532 Hsd17b12 56348 MGI:1926967 -0.871993228 Evi5l 213027 MGI:2442167 -0.875575854 Fyn 14360 MGI:95602 -0.914800455 Scg3 20255 MGI:103032 -0.925936194 Dock9 105445 MGI:106321 -0.928531697 Cyb5r4 266690 MGI:2386848 -0.985621685 Fzd8 14370 MGI:108460 -0.999862406 Ufc1 66155 MGI:1913405 -1.006264457 Idh1 15926 MGI:96413 -1.010027922 Epb41l1 13821 MGI:103010 -1.017014907 Gfod1 328232 MGI:2145304 -1.032815282 4921524J17Rik66714 MGI:1913964 -1.033194563 Cdh2 12558 MGI:88355 -1.045510351 Msmo1 66234 MGI:1913484 -1.04924605 Gm15663 327812 MGI:3783105 -1.056931316 Lrig3 320398 MGI:2443955 -1.068035559 Pcdh7 54216 MGI:1860487 -1.074569831 Igsf3 78908 MGI:1926158 -1.074671155 Hmgcs1 208715 MGI:107592 -1.08140318 Chtop 66511 MGI:1913761 -1.081480183 Rap1gds1 229877 MGI:2385189 -1.094185205 No associated gene -1.096130021 Homer1 26556 MGI:1347345 -1.098062505 Tnk2 51789 MGI:1858308 -1.100474657 Snx18 170625 MGI:2137642 -1.102120104 No associated gene -1.122267287 Ippk 75678 MGI:1922928 -1.133349061 Klc1 16593 MGI:107978 -1.133468419 Ppp2r3a 235542 MGI:2442104 -1.137822481 Dpysl4 26757 MGI:1349764 -1.142818297 No associated gene -1.147903986 N4bp2l2 381695 MGI:2687207 -1.150551152 Zfyve28 231125 MGI:2684992 -1.15869594 Psmb5 19173 MGI:1194513 -1.177222474 Gm15459 727711 MGI:3705702 -1.200581548 Rtl6 223732 MGI:2675858 -1.213839256 Marveld1 277010 MGI:2147570 -1.215150576 Trim2 80890 MGI:1933163 -1.222028569 Adgrl2 99633 MGI:2139714 -1.22286004 Kcna5 16493 MGI:96662 -1.230578748 Crmp1 12933 MGI:107793 -1.231820246 Slain1 105439 MGI:2145578 -1.243399931 Cd81 12520 MGI:1096398 -1.260884771 Rbmx 19655 MGI:1343044 -1.263922685 Mlh1 17350 MGI:101938 -1.266810967 Golga5 27277 MGI:1351475 -1.272015657 Dll1 13388 MGI:104659 -1.283792136 Slc14a1 108052 MGI:1351654 -1.283809952 Ocel1 77090 MGI:1924340 -1.298364951 Cdk2ap1 13445 MGI:1202069 -1.312135761 Kbtbd11 74901 MGI:1922151 -1.312859128 Mapk8ip1 19099 MGI:1309464 -1.320870499 Dars2 226539 MGI:2442510 -1.329073221 Agrn 11603 MGI:87961 -1.331535595 Pcdh9 211712 MGI:1306801 -1.342763594 Mcam 84004 MGI:1933966 -1.343179637 Ell2 192657 MGI:2183438 -1.36194008 Adam22 11496 MGI:1340046 -1.364064265 B130055M24Rik654803 MGI:3590645 -1.369670983 Emc10 69683 MGI:1916933 -1.372634354 Acsl1 14081 MGI:102797 -1.391848976 Prdx1 18477 MGI:99523 -1.401333811 Dok7 231134 MGI:3584043 -1.40999611 Spef1 70997 MGI:3513546 -1.411790367 Hs6st1 50785 MGI:1354958 -1.412063892 Ccdc85c 668158 MGI:3644008 -1.417905472 Rps6ka5 73086 MGI:1920336 -1.441173754 Garem2 242915 MGI:2685290 -1.452257998 Wdr5b 69544 MGI:1916794 -1.465359607 Actb 11461 MGI:87904 -1.467574029 Rab10os 74173 MGI:1921423 -1.482535342 Zbtb14 22666 MGI:1195345 -1.489716139 Grik3 14807 MGI:95816 -1.498353595 No associated gene -1.50567074 Rims4 241770 MGI:2674366 -1.50675149 Secisbp2l 70354 MGI:1917604 -1.510174878 Klhl13 67455 MGI:1914705 -1.513033256 Sorcs1 58178 MGI:1929666 -1.525970852 Pcdh10 18526 MGI:1338042 -1.545432609 Nkain3 269513 MGI:2444830 -1.552955335 Tmod2 50876 MGI:1355335 -1.557008762 Poglut1 224143 MGI:2444232 -1.559235149 No associated gene -1.559474421 Tns1 21961 MGI:104552 -1.560187249 Pcdhb2 93873 MGI:2136735 -1.56064374 Ahcyl2 74340 MGI:1921590 -1.581080102 Zfp207 22680 MGI:1340045 -1.587981058 Tprn 97031 MGI:2139535 -1.628616999 Llgl1 16897 MGI:102682 -1.63636543 Dpagt1 13478 MGI:1196396 -1.664819761 Zfp563 240068 MGI:2677168 -1.676493844 Plcl2 224860 MGI:1352756 -1.679384055 Rnf38 73469 MGI:1920719 -1.700939596 Tmem163 72160 MGI:1919410 -1.711805597 6330403L08Rik70744 MGI:1917994 -1.723828188 Tssc4 56844 MGI:1861712 -1.736804995 Comt 12846 MGI:88470 -1.740036289 Casp7 12369 MGI:109383 -1.741738813 Slc8a1 20541 MGI:107956 -1.745539806 Tssc4 56844 MGI:1861712 -1.781504112 Itpr2 16439 MGI:99418 -1.781902888 Tmem163 72160 MGI:1919410 -1.821577897 Robo2 268902 MGI:1890110 -1.825644975 Ncor2 20602 MGI:1337080 -1.835107609 Cep170b 217882 MGI:2145043 -1.852535119 Stx2 13852 MGI:108059 -1.863131119 Pea15a 18611 MGI:104799 -1.895276183 Ephb1 270190 MGI:1096337 -1.895770329 Prepl 213760 MGI:2441932 -1.918815734 Akr1e1 56043 MGI:1914758 -1.928215253 Zfp276 57247 MGI:1888495 -1.950236562 Col4a1 12826 MGI:88454 -1.970771682 Tspan9 109246 MGI:1924558 -2.0140352 Adap1 231821 MGI:2442201 -2.067426354 Lyrm7 75530 MGI:1922780 -2.070051164 Rassf10 78748 MGI:1925998 -2.074934016 Tmem158 72309 MGI:1919559 -2.108122993 Map3k20 65964 MGI:2443258 -2.109642524 No associated gene -2.112068983 Zfp456 408065 MGI:3040694 -2.126507253 Fam107b 66540 MGI:1913790 -2.147572354 Ing4 28019 MGI:107307 -2.154541761 Dpysl5 65254 MGI:1929772 -2.172528199 6530402F18Rik76220 MGI:1923470 -2.219540203 Nrxn1 18189 MGI:1096391 -2.222618537 Map2 17756 MGI:97175 -2.238145925 Hs3st3b1 54710 MGI:1333853 -2.333106116 Gm13835 100038973 MGI:3650921 -2.334631268 Pttg1 30939 MGI:1353578 -2.351022847 Bend6 320705 MGI:2444572 -2.3639505 Fhl2 14200 MGI:1338762 -2.368599235 Gnb1 14688 MGI:95781 -2.438235271 Sgip1 73094 MGI:1920344 -2.464622997 Syk 20963 MGI:99515 -2.473612303 Nckap5 210356 MGI:2686394 -2.486165894 Cemip2 83921 MGI:1890373 -2.487262303 Tmx2 66958 MGI:1914208 -2.521839668 Slain1 105439 MGI:2145578 -2.533456567 Klhl20 226541 MGI:2444855 -2.535164483 Dnajb5 56323 MGI:1930018 -2.565444514 Dst 13518 MGI:104627 -2.574046794 Ppm1m 67905 MGI:1915155 -2.582550907 Pcdha11 12942 MGI:1298372 -2.613834234 Foxn3 71375 MGI:1918625 -2.623625748 Grm5 108071 MGI:1351342 -2.633967811 Dhdds 67422 MGI:1914672 -2.655836689 Abhd14a 68644 MGI:1915894 -2.692875792 Dph5 69740 MGI:1916990 -2.710543538 Grm5 108071 MGI:1351342 -2.725889505 Cuedc2 67116 MGI:1914366 -2.741971009 Cuedc2 67116 MGI:1914366 -2.772428698 Txndc15 69672 MGI:1916922 -2.775886734 Plch2 269615 MGI:2443078 -2.803370569 Ehd3 57440 MGI:1928900 -2.807777634 Neurl1a 18011 MGI:1334263 -2.827428658 Ing4 28019 MGI:107307 -2.861771511 Gm8730 667618 MGI:3644565 -2.866709646 Ing3 71777 MGI:1919027 -2.887032065 Usp54 78787 MGI:1926037 -2.9210508 Gm9625 674597 MGI:3780033 -2.923614303 Dmap1 66233 MGI:1913483 -2.957131649 Epb41l3 13823 MGI:103008 -2.964667257 Fancb 237211 MGI:2448558 -2.968537905 Igfbpl1 75426 MGI:1933198 -2.975043293 Man1a 17155 MGI:104677 -2.976308796 Zfp747 269997 MGI:2443581 -2.986442457 Tsc22d4 78829 MGI:1926079 -3.003411596 Tsc22d3 14605 MGI:1196284 -3.058707884 Armc9 78795 MGI:1926045 -3.081062056 Zfp709 236193 MGI:2384299 -3.091945597 S1pr5 94226 MGI:2150641 -3.097389802 Gm20482 102632136 MGI:5141947 -3.110642719 Rpl29 19944 MGI:99687 -3.117622394 Pcdhga3 93711 MGI:1935215 -3.1228456 Hipk1 15257 MGI:1314873 -3.137405476 Fance 72775 MGI:1920025 -3.149339745 Myo1e 71602 MGI:106621 -3.150237032 Mfsd13a 75146 MGI:1922396 -3.158564428 Bfsp2 107993 MGI:1333828 -3.16600231 Ntng2 171171 MGI:2159341 -3.175701961 Mia2 338320 MGI:2159614 -3.1765205 Nynrin 277154 MGI:2652872 -3.218343233 Sap18 20220 MGI:1277978 -3.2334992 Inka2 109050 MGI:1923497 -3.24947938 Gm6166 101056162 MGI:3645893 -3.270380443 Obscn 380698 MGI:2681862 -3.285497246 Thap1 73754 MGI:1921004 -3.297888691 Obscn 380698 MGI:2681862 -3.30211616 Tmsb15b2 100034363 MGI:3843061 -3.305964404 Tubg2 103768 MGI:2144208 -3.307820344 Sulf1 240725 MGI:2138563 -3.31420264 Dlg3 53310 MGI:1888986 -3.322511972 Gdpd3 68616 MGI:1915866 -3.361570108 Gsto1 14873 MGI:1342273 -3.363698735 Mtus2 77521 MGI:1915388 -3.371818068 Plch2 269615 MGI:2443078 -3.389374944 Mfsd13a 75146 MGI:1922396 -3.4326188 Cct3 12462 MGI:104708 -3.435861403 Dis3l 213550 MGI:2143272 -3.469974931 Kifbp 72320 MGI:1919570 -3.487660579 Rpl29 19944 MGI:99687 -3.512480656 Elp1 230233 MGI:1914544 -3.545300012 AW209491 105351 MGI:2145422 -3.553493425 Carmil1 68732 MGI:1915982 -3.564938241 Nrxn1 18189 MGI:1096391 -3.584313673 Gm5128 331529 MGI:3647038 -3.592083166 Gm7903 666040 MGI:3648697 -3.592083166 Cyb5a 109672 MGI:1926952 -3.642552881 Zfp882 382019 MGI:3642748 -3.723093706 Cln3 12752 MGI:107537 -3.850597353 Itga2 16398 MGI:96600 -3.866410843 Tmem223 66836 MGI:1914086 -3.939652566 Carmil1 68732 MGI:1915982 -3.947024621 9130019O22Rik78921 MGI:1926171 -4.026935162 A230056P14Rik320845 MGI:2444856 -4.029218535 Trf 22041 MGI:98821 -4.040998714 2610507I01Rik72203 MGI:1919453 -4.042823303 Hapln2 73940 MGI:2137300 -4.087049536 Rian 75745 MGI:1922995 -4.095449819 Cln3 12752 MGI:107537 -4.100201141 1500015A07Rik68982 MGI:1916232 -4.174062777 Carmil1 68732 MGI:1915982 -4.200718644 Cradd 12905 MGI:1336168 -4.2821966 Ppp1r17 19051 MGI:1333876 -4.388962915 Wnk1 232341 MGI:2442092 -4.397007074 Gusb 110006 MGI:95872 -4.460198831 Zfp563 240068 MGI:2677168 -4.606807718 Eda2r 245527 MGI:2442860 -4.725806985 E430018J23Rik101604 MGI:2141981 -4.786810681 Igsf21 230868 MGI:2681842 -4.838374755 Gstk1 76263 MGI:1923513 -5.175877146 Tshz3 243931 MGI:2442819 -5.580953596 Cln3 12752 MGI:107537 -5.638255456 Csmd2 329942 MGI:2386401 -5.641064871 Miga1 215708 MGI:1924567 -5.728369006 9130019O22Rik78921 MGI:1926171 -5.80053442 Shld1 73747 MGI:1920997 -5.870300369 Zfp882 382019 MGI:3642748 -7.277044048 Miga1 215708 MGI:1924567 -7.774550621 Ech1 51798 MGI:1858208 -7.973663718 Csmd2 329942 MGI:2386401 -8.111990119 Table S1: Thap1 +/+ Vs Thap1 -/- DEG - DIV 4 Official_Gene Entrez Gene IDMGI Gene/Marker ID log2FoldChange.4D Gm22988 MGI:5452765 5.688626 Pax9 18511 MGI:97493 5.570917 Anxa6 11749 MGI:88255 5.320343 Gm13841 665032 MGI:3650890 4.746741 Ott 18422 MGI:107573 4.65879 Gm15085 100039934 MGI:3712210 4.65879 Gm15093 100039890 MGI:3712496 4.575049 Gm12663 105274305 MGI:3652168 4.526139 Hus1 15574 MGI:1277962 4.507918 Gucy2f 245650 MGI:105119 4.311187 Cdh18 320865 MGI:1344366 4.175093 Btbd11 74007 MGI:1921257 3.966258 Gm10439 382243 MGI:3710525 3.957498 Chst5 56773 MGI:1931825 3.957334 Fxr2 23879 MGI:1346074 3.919779 Pyroxd2 74580 MGI:1921830 3.886407 Morf4l2 56397 MGI:1927167 3.880707 Mpg 268395 MGI:97073 3.866524 Tbc1d1 57915 MGI:1889508 3.854832 Sfmbt2 353282 MGI:2447794 3.78414 Hmgcs2 15360 MGI:101939 3.783179 Vax1 22326 MGI:1277163 3.779122 Cuedc1 103841 MGI:2144281 3.745636 Map7d2 78283 MGI:1917474 3.71528 Pde8b 218461 MGI:2443999 3.682511 Baiap2 108100 MGI:2137336 3.675352 St3gal6 54613 MGI:1888707 3.659861 Scarf1 380713 MGI:2449455 3.576333 Acan 11595 MGI:99602 3.53978 Abhd12 76192 MGI:1923442 3.520274 Rab34 19376 MGI:104606 3.511005 Nin 18080 MGI:105108 3.502557 Rbm10 236732 MGI:2384310 3.502016 Eif4a2 13682 MGI:106906 3.487461 Adam11 11488 MGI:1098667 3.460161 Gm23946 MGI:5453723 3.447079 Utp18 217109 MGI:1923402 3.440534 Tmem214 68796 MGI:1916046 3.39877 Abca6 76184 MGI:1923434 3.377984 Sphk1 20698 MGI:1316649 3.355146 Asph 65973 MGI:1914186 3.33883 Ramp2 54409 MGI:1859650 3.336063 Nme1 18102 MGI:97355 3.334586 Hyi 68180 MGI:1915430 3.270435 Camk2d 108058 MGI:1341265 3.262258 Gm11868 667251 MGI:3650507 3.249615 Gm10719 MGI:3641690 3.241006 Gas5 14455 MGI:95659 3.230095 Plcd1 18799 MGI:97614 3.224555 Gm11520 102640811 MGI:3650534 3.214099 Ankhd1 108857 MGI:1921733 3.209433 Luzp4 434865 MGI:3708816 3.204494 Tmem63b 224807 MGI:2387609 3.191454 Igsf1 209268 MGI:2147913 3.160407 Rhoj 80837 MGI:1931551 3.149134 Plin2 11520 MGI:87920 3.137133 Myh14 71960 MGI:1919210 3.132091 Col2a1 12824 MGI:88452 3.11895 Arhgap44 216831 MGI:2144423 3.100663 Bicd1 12121 MGI:1101760 3.095686 Zbtb20 56490 MGI:1929213 3.089551 Cast 12380 MGI:1098236 3.082706 Gdnf 14573 MGI:107430 3.053909 Rara 19401 MGI:97856 3.052051 Col18a1 12822 MGI:88451 3.05182 Farp2 227377 MGI:2385126 3.040605 Cobll1 319876 MGI:2442894 3.028024 Eif5a 276770 MGI:106248 3.016474 Cdc42ep5 58804 MGI:1929745 3.01357 Tomm22 223696 MGI:2450248 2.99508 Nid1 18073 MGI:97342 2.992271 Zbtb38 245007 MGI:2442866 2.977053 Fndc3c1 333564 MGI:2685630 2.976085 Eif2s2 67204 MGI:1914454 2.971466 Npepl1 228961 MGI:2448523 2.966064 Cdh8 12564 MGI:107434 2.961069 Cpne8 66871 MGI:1914121 2.937599 Hs6st2 50786 MGI:1354959 2.921493 Efcab1 66793 MGI:1914043 2.917655 Ucp2 22228 MGI:109354 2.882247 Wdsub1 72137 MGI:1919387 2.872887 Snora74a 436583 MGI:3646921 2.852439 Gm13337 637235 MGI:3650269 2.851385 Psmd3 22123 MGI:98858 2.845649 Scara5 71145 MGI:1918395 2.844951 Elf2 69257 MGI:1916507 2.844276 Plch1 269437 MGI:2683547 2.803556 Slc39a14 213053 MGI:2384851 2.800306 Dnhd1 77505 MGI:1924755 2.799415 Sparc 20692 MGI:98373 2.788615 Fggy 75578 MGI:1922828 2.786698 Rnaseh2a 69724 MGI:1916974 2.783183 Trpv4 63873 MGI:1926945 2.774687 Tbl3 213773 MGI:2384863 2.763544 Ift20 55978 MGI:1915585 2.755255 Rnf20 109331 MGI:1925927 2.728671 Ddn 13199 MGI:108101 2.715425 Col16a1 107581 MGI:1095396 2.692578 Akt1s1 67605 MGI:1914855 2.68122 Slc8b1 170756 MGI:2180781 2.657123 Gm12250 631323 MGI:3649299 2.656695 Rpl3-ps1 100043000 MGI:3644217 2.655623 Scube3 268935 MGI:3045253 2.651874 Cthrc1 68588 MGI:1915838 2.648614 Rasgef1a 70727 MGI:1917977 2.62425 C77080 97130 MGI:2140651 2.619101 Dtx2 74198 MGI:1921448 2.611218 Slc25a11 67863 MGI:1915113 2.592692 Rbfox1 268859 MGI:1926224 2.574494 Rnu2-10 19848 MGI:97976 2.573225 Gm24950 115487917 MGI:5454727 2.530609 Gm23849 MGI:5453626 2.52896 Alk 11682 MGI:103305 2.521576 Gm25360 115487690 MGI:5455137 2.518649 Gm23472 115487687 MGI:5453249 2.518013 Dock2 94176 MGI:2149010 2.505959 Arhgef6 73341 MGI:1920591 2.501224 Sptb 20741 MGI:98387 2.494927 Zfp429 72807 MGI:1920057 2.476225 Fam114a1 68303 MGI:1915553 2.456512 Itgb3 16416 MGI:96612 2.440024 Pter 19212 MGI:107372 2.425797 Grb10 14783 MGI:103232 2.418998 Phtf2 68770 MGI:1916020 2.414767 Mfge8 17304 MGI:102768 2.37704 Ttyh2 117160 MGI:2157091 2.373928 Sf1 22668 MGI:1095403 2.367853 Mical1 171580 MGI:2385847 2.325745 Snora73b 100306945 MGI:4360049 2.316129 Gm7901 666036 MGI:3645047 2.308765 Eya4 14051 MGI:1337104 2.306763 Lrrtm4 243499 MGI:2389180 2.294211 Aqp1 11826 MGI:103201 2.293578 Gm25117 115487522 MGI:5454894 2.289004 Pycr1 209027 MGI:2384795 2.287358 Gpr176 381413 MGI:2685858 2.266111 Nptx1 18164 MGI:107811 2.259006 Col11a2 12815 MGI:88447 2.241605 Gm23971 115487918 MGI:5453748 2.239127 Gm25835 115487914 MGI:5455612 2.228574 Pcdh8 18530 MGI:1306800 2.221766 Mbtd1 103537 MGI:2143977 2.21203 Col9a3 12841 MGI:894686 2.20529 Prokr1 58182 MGI:1929676 2.196911 Tmem117 320709 MGI:2444580 2.180564 4632428C04Rik100043102 MGI:1921600 2.160016 Gm7887 666005 MGI:3648251 2.157091 Cbx1 12412 MGI:105369 2.150049 Herpud1 64209 MGI:1927406 2.149224 Tuba1c 22146 MGI:1095409 2.146997 Mxra8 74761 MGI:1922011 2.14203 Skiv2l 108077 MGI:1099835 2.126991 Gm24305 MGI:5454082 2.125112 Myo1c 17913 MGI:106612 2.124291 9930014A18Rik320469 MGI:2444091 2.1082 Aebp1 11568 MGI:1197012 2.103096 Scarna6 100217415 MGI:3819487 2.096727 Celf4 108013 MGI:1932407 2.092197 Gt(ROSA)26Sor14910 MGI:104735 2.090652 C1qtnf1 56745 MGI:1919254 2.089228 Gm22317 115488075 MGI:5452094 2.065191 Gm25679 115488073 MGI:5455456 2.063107 Irgm1 15944 MGI:107567 2.048575 Sh3tc2 225608 MGI:2444417 2.03447 Stk10 20868 MGI:1099439 2.024564 Rgmb 68799 MGI:1916049 1.99753 Gm14150 100043840 MGI:3651006 1.988725 Fam174b 100038347 MGI:3698178 1.96432 H6pd 100198 MGI:2140356 1.957742 Hey2 15214 MGI:1341884 1.950939 Mink1 50932 MGI:1355329 1.948685 Dct 13190 MGI:102563 1.940589 Gm22513 115488051 MGI:5452290 1.93414 Tbkbp1 73174 MGI:1920424 1.933694 Syt4 20983 MGI:101759 1.930665 Slc39a11 69806 MGI:1917056 1.919927 Erp27 69187 MGI:1916437 1.915317 Ankrd13b 268445 MGI:2144501 1.907699 Mrpl55 67212 MGI:1914462 1.905712 Fam117a 215512 MGI:2144564 1.904387 Tmem181b-ps 547127 MGI:3779544 1.877185 Snrnp35 76167 MGI:1923417 1.866903 Reln 19699 MGI:103022 1.848117 Ninj2 29862 MGI:1352751 1.847141 Pcolce2 76477 MGI:1923727 1.831512 Glce 93683 MGI:2136405 1.826279 Bcat1 12035 MGI:104861 1.809882 Hspg2 15530 MGI:96257 1.808783 Hspa8 15481 MGI:105384 1.803314 D630003M21Rik228846 MGI:3606579 1.770147 Snora73a 100306944 MGI:4360046 1.726905 Sema7a 20361 MGI:1306826 1.721797 Afap1l2 226250 MGI:2147658 1.720378 Rgcc 66214 MGI:1913464 1.682466 Gfpt2 14584 MGI:1338883 1.669842 Pxdn 69675 MGI:1916925 1.668795 Fam89a 69627 MGI:1916877 1.65109 Slc25a13 50799 MGI:1354721 1.649563 Tenm3 23965 MGI:1345183 1.646536 Aars2 224805 MGI:2681839 1.629968 Sh3bp5 24056 MGI:1344391 1.616477 Tfap4 83383 MGI:103239 1.600441 Smyd5 232187 MGI:108048 1.598652 Trmt1 212528 MGI:1289155 1.584562 Slc35b1 110172 MGI:1343133 1.581187 Galnt2 108148 MGI:894694 1.576817 Car11 12348 MGI:1336193 1.564862 Fbn1 14118 MGI:95489 1.559294 Arrb1 109689 MGI:99473 1.557874 Dnajc7 56354 MGI:1928373 1.555857 Kcnk1 16525 MGI:109322 1.555535 Bche 12038 MGI:894278 1.554682 Kat2a 14534 MGI:1343101 1.539508 Rbms1 56878 MGI:1861774 1.524671 Abhd1 57742 MGI:1931013 1.52358 Clvs1 74438 MGI:1921688 1.518873 Afap1l1 106877 MGI:2147199 1.518512 Tsr1 104662 MGI:2144566 1.512235 Sco1 52892 MGI:106362 1.509517 Fbxl2 72179 MGI:1919429 1.505069 Gm26448 115487256 MGI:5456225 1.499224 Gpatch4 66614 MGI:1913864 1.493834 Rptor 74370 MGI:1921620 1.484796 Cited1 12705 MGI:108023 1.477601 Myh10 77579 MGI:1930780 1.475572 Rab11fip4 268451 MGI:2442920 1.474152 Smoc1 64075 MGI:1929878 1.46344 Clint1 216705 MGI:2144243 1.446267 Prpf8 192159 MGI:2179381 1.441317 Eif1 20918 MGI:105125 1.435433 Rnd3 74194 MGI:1921444 1.435101 Phgdh 236539 MGI:1355330 1.429892 Gfra2 14586 MGI:1195462 1.429707 Tgfb3 21809 MGI:98727 1.425712 Pvt1 19296 MGI:97824 1.422585 Rars 104458 MGI:1914297 1.420659 Hemk1 69536 MGI:1916786 1.4049 Mapt 17762 MGI:97180 1.396277 Kremen1 84035 MGI:1933988 1.391313 Spata6 67946 MGI:1915196 1.386129 Ppfibp1 67533 MGI:1914783 1.376526 Cpd 12874 MGI:107265 1.374322 Cnot1 234594 MGI:2442402 1.359391 Tmem17 103765 MGI:2144205 1.33563 Lyrm9 66274 MGI:1913524 1.326472 Nradd 67169 MGI:1914419 1.324882 Efs 13644 MGI:105311 1.318711 Bptf 207165 MGI:2444008 1.316173 Rcor3 214742 MGI:2441920 1.308951 Slc45a4 106068 MGI:2146236 1.306164 Kcna1 16485 MGI:96654 1.301992 Tmtc4 70551 MGI:1921050 1.299117 Ano10 102566 MGI:2143103 1.294811 Hr 15460 MGI:96223 1.292437 Gbp3 55932 MGI:1926263 1.281647 Traf4 22032 MGI:1202880 1.269024 Snx22 382083 MGI:2685966 1.25193 Cmtm3 68119 MGI:2447162 1.246593 Mkx 210719 MGI:2687286 1.246133 Pigs 276846 MGI:2687325 1.239123 Mthfd1l 270685 MGI:1924836 1.236506 Slc26a2 13521 MGI:892977 1.217914 Bend3 331623 MGI:2677212 1.216506 Dag1 13138 MGI:101864 1.214174 St3gal4 20443 MGI:1316743 1.213367 A730017L22Rik613258 MGI:3584452 1.211484 Mb21d2 239796 MGI:1917028 1.209788 Scamp2 24044 MGI:1346518 1.209118 Shmt2 108037 MGI:1277989 1.205088 Tmem150a 232086 MGI:2385244 1.188347 Gaa 14387 MGI:95609 1.182443 Trp53 22059 MGI:98834 1.178999 Tpbg 21983 MGI:1341264 1.178848 Gm2a 14667 MGI:95762 1.178682 Ddit3 13198 MGI:109247 1.174814 Nfe2l1 18023 MGI:99421 1.173936 Flnb 286940 MGI:2446089 1.16275 Acsl6 216739 MGI:894291 1.156406 Rsph9 75564 MGI:1922814 1.156208 Tmprss5 80893 MGI:1933407 1.150221 Ears2 67417 MGI:1914667 1.147482 Gpr180 58245 MGI:1930949 1.132515 4930570G19Rik329782 MGI:1923158 1.126883 Igf2r 16004 MGI:96435 1.123237 Ezh1 14055 MGI:1097695 1.121644 Mapk9 26420 MGI:1346862 1.090748 Tex2 21763 MGI:102465 1.09055 Cnot11 52846 MGI:106580 1.089561 Smg6 103677 MGI:2144117 1.083208 Mef2a 17258 MGI:99532 1.081048 Ranbp17 66011 MGI:1929706 1.078068 Csnk1d 104318 MGI:1355272 1.062583 Rps6ka2 20112 MGI:1342290 1.06145 Slc2a1 20525 MGI:95755 1.061311 Chtf8 214987 MGI:2443370 1.059173 Sec31a 69162 MGI:1916412 1.059113 Ermp1 226090 MGI:106250 1.057724 Supt6 20926 MGI:107726 1.054791 Atic 108147 MGI:1351352 1.052739 Aatf 56321 MGI:1929608 1.04668 Arf6 11845 MGI:99435 1.046025 Aars 234734 MGI:2384560 1.028752 Srebf1 20787 MGI:107606 1.020135 Tbc1d10a 103724 MGI:2144164 1.012611 Naglu 27419 MGI:1351641 1.000462 Lrrc59 98238 MGI:2138133 0.998572 Cttnbp2nl 80281 MGI:1933137 0.995572 Ulk3 71742 MGI:1918992 0.992593 Grwd1 101612 MGI:2141989 0.988224 Sqstm1 18412 MGI:107931 0.979754 Gna13 14674 MGI:95768 0.977786 Golga2 99412 MGI:2139395 0.975384 Nudt16 75686 MGI:1922936 0.969696 Arrb2 216869 MGI:99474 0.966727 Rabep1 54189 MGI:1860236 0.961718 Armcx2 67416 MGI:1914666 0.953676 Zfp14 243906 MGI:99160 0.941811 Prpsap1 67763 MGI:1915013 0.940924 Irf1 16362 MGI:96590 0.939327 Dcaf15 212123 MGI:2684420 0.936803 Gid4 66771 MGI:1914021 0.936417 Hspa9 15526 MGI:96245 0.935824 Xpot 73192 MGI:1920442 0.932422 Mri1 67873 MGI:1915123 0.93089 Osbpl7 71240 MGI:1918490 0.928564 Gars 353172 MGI:2449057 0.927357 Nr2c1 22025 MGI:1352465 0.925835 Lhpp 76429 MGI:1923679 0.924841 Sars 20226 MGI:102809 0.922921 Mtmr3 74302 MGI:1921552 0.922386 Ppp2r3c 59032 MGI:1930009 0.920951 Kctd3 226823 MGI:2444629 0.915266 Klf10 21847 MGI:1101353 0.913618 Slc35g1 240660 MGI:2444789 0.912304 Cdk5rap3 80280 MGI:1933126 0.90909 Abl2 11352 MGI:87860 0.909086 Mpi 110119 MGI:97075 0.905934 Nop14 75416 MGI:1922666 0.905834 Gmeb1 56809 MGI:2135604 0.900482 Psmd7 17463 MGI:1351511 0.895131 Jmjd6 107817 MGI:1858910 0.883006 Mafg 17134 MGI:96911 0.877977 Gm13456 666531 MGI:3651389 0.875814 Uggt2 66435 MGI:1913685 0.875477 Srm 20810 MGI:102690 0.874776 Pdpr 319518 MGI:2442188 0.868253 Imp4 27993 MGI:106572 0.866722 Cmtr2 234728 MGI:2384580 0.858162 Foxj3 230700 MGI:2443432 0.853605 Abcb6 74104 MGI:1921354 0.851881 C1ql3 227580 MGI:2387350 0.843737 Dlg4 13385 MGI:1277959 0.838624 Urb2 382038 MGI:2681124 0.823574 Gpcpd1 74182 MGI:104898 0.822647 Nr2c2ap 75692 MGI:1922942 0.82239 Zfp3 193043 MGI:99177 0.819123 Nomo1 211548 MGI:2385850 0.817068 Dph5 69740 MGI:1916990 0.811622 Col11a1 12814 MGI:88446 0.795341 Tpm1 22003 MGI:98809 0.791413 Cbx4 12418 MGI:1195985 0.789249 Polr3e 26939 MGI:1349452 0.787476 Itfg2 101142 MGI:1915450 0.783378 Ftsj3 56095 MGI:1860295 0.782139 Got2 14719 MGI:95792 0.777767 Slc4a7 218756 MGI:2443878 0.771985 Thoc5 107829 MGI:1351333 0.771812 Rhou 69581 MGI:1916831 0.77122 Foxn2 14236 MGI:1347478 0.768206 Socs7 192157 MGI:2651588 0.756696 Dhx33 216877 MGI:2445102 0.751737 Man2a2 140481 MGI:2150656 0.741348 Npm1 18148 MGI:106184 0.739632 Ndufv3 78330 MGI:1890894 0.739354 Trim44 80985 MGI:1931835 0.737747 2810021J22Rik69944 MGI:1917194 0.725171 Ube2o 217342 MGI:2444266 0.71842 Atad3a 108888 MGI:1919214 0.708133 Dennd1b 329260 MGI:2447812 0.694207 Ddx18 66942 MGI:1914192 0.693375 Cep68 216543 MGI:2667663 0.692427 Caskin2 140721 MGI:2157062 0.690298 Atp1a1 11928 MGI:88105 0.683382 Eprs 107508 MGI:97838 0.677073 Klhl11 217194 MGI:2388648 0.675373 Polr1b 20017 MGI:108014 0.66786 Galnt16 108760 MGI:1917754 0.665251 Sugp1 70616 MGI:1917866 0.664995 Eefsec 65967 MGI:2137092 0.662718 Thumpd1 233802 MGI:2444479 0.66104 Zbtb17 22642 MGI:107410 0.648596 Prep 19072 MGI:1270863 0.647216 Polr1a 20019 MGI:1096397 0.646493 Xylt2 217119 MGI:2444797 0.646121 Nop56 67134 MGI:1914384 0.64257 Wdr46 57315 MGI:1931871 0.642211 Wdr3 269470 MGI:2443143 0.633514 Golga3 269682 MGI:96958 0.63068 Hipk3 15259 MGI:1314882 0.63065 Casp2 12366 MGI:97295 0.626212 Zc3h7a 106205 MGI:2445044 0.62546 Tbc1d23 67581 MGI:1914831 0.611515 Ncam1 17967 MGI:97281 0.603363 Vezf1 22344 MGI:1313291 0.601278 Gnl3 30877 MGI:1353651 0.599776 Efr3a 76740 MGI:1923990 0.586461 Nsun2 28114 MGI:107252 0.583306 Ap1b1 11764 MGI:1096368 0.582887 Rad23b 19359 MGI:105128 0.581331 Parn 74108 MGI:1921358 0.573099 Sart1 20227 MGI:1309453 0.549376 Fbxo45 268882 MGI:2447775 0.530658 Rcc2 108911 MGI:1919784 0.528536 Snx1 56440 MGI:1928395 0.527203 Tmed3 66111 MGI:1913361 0.524468 Slc25a39 68066 MGI:1196386 0.520121 Ctcf 13018 MGI:109447 0.513762 Hdac1 433759 MGI:108086 0.512287 Ganab 14376 MGI:1097667 0.509929 Mzt1 76789 MGI:1924039 0.506056 Tbrg1 21376 MGI:1100877 0.497562 Mcmbp 210711 MGI:1920977 0.48512 Hbs1l 56422 MGI:1891704 0.480281 Elp3 74195 MGI:1921445 0.473653 Ahi1 52906 MGI:87971 0.473102 Ankle2 71782 MGI:1261856 0.444438 Tomm34 67145 MGI:1914395 0.441181 Samd8 67630 MGI:1914880 0.403877 Atp13a1 170759 MGI:2180801 0.39625 Cpsf1 94230 MGI:2679722 0.383988 Scd2 20250 MGI:98240 -0.462138 Unc119b 106840 MGI:2147162 -0.470893 Zfp334 228876 MGI:2388656 -0.490463 Psenen 66340 MGI:1913590 -0.493251 Sike1 66641 MGI:1913891 -0.519136 Tmod3 50875 MGI:1355315 -0.528366 Abhd8 64296 MGI:1918946 -0.53467 Ensa 56205 MGI:1891189 -0.542898 Aph1b 208117 MGI:3522097 -0.544043 Rhoa 11848 MGI:1096342 -0.554044 Arpc4 68089 MGI:1915339 -0.572335 Mlf2 30853 MGI:1353554 -0.575257 Kras 16653 MGI:96680 -0.575343 Tada1 27878 MGI:1196415 -0.582858 Srsf7 225027 MGI:1926232 -0.592718 Ube2n 93765 MGI:1934835 -0.597057 Sh3gl1 20405 MGI:700010 -0.618353 Vrk3 101568 MGI:2182465 -0.619587 mt-Nd5 17721 MGI:102496 -0.634199 Acat1 110446 MGI:87870 -0.639902 Dnaja1 15502 MGI:1270129 -0.642393 Myl6 17904 MGI:109318 -0.649478 Cacybp 12301 MGI:1270839 -0.666019 Uqcrb 67530 MGI:1914780 -0.676816 Slc20a2 20516 MGI:97851 -0.678139 Tiprl 226591 MGI:1915087 -0.678156 Tmem170b 621976 MGI:3647046 -0.686736 BC005624 227707 MGI:2385132 -0.694018 Sri 109552 MGI:98419 -0.712566 Slc16a1 20501 MGI:106013 -0.729268 Nap1l4 17955 MGI:1316687 -0.73792 Pgam1 18648 MGI:97552 -0.75079 Fibp 58249 MGI:1926233 -0.756238 Pnrc2 52830 MGI:106512 -0.756725 Pfkl 18641 MGI:97547 -0.756916 Cby1 73739 MGI:1920989 -0.758633 Exoc4 20336 MGI:1096376 -0.771218 Usp54 78787 MGI:1926037 -0.777074 Immp1l 66541 MGI:1913791 -0.77859 Brk1 101314 MGI:1915406 -0.779522 Ndfip2 76273 MGI:1923523 -0.781539 Cox6b1 110323 MGI:107460 -0.790166 Ndufa11 69875 MGI:1917125 -0.804853 Mxd1 17119 MGI:96908 -0.819326 Dynlt1f 100040531 MGI:3780996 -0.823797 Prdx2 21672 MGI:109486 -0.828803 Echdc1 52665 MGI:1277169 -0.837724 Gtf2h5 66467 MGI:107227 -0.848467 Cyb5r4 266690 MGI:2386848 -0.857675 Vbp1 22327 MGI:1333804 -0.859633 Smarcc2 68094 MGI:1915344 -0.860318 Fam131b 76156 MGI:1923406 -0.861234 Hsbp1 68196 MGI:1915446 -0.864394 Nfe2l2 18024 MGI:108420 -0.879271 Rchy1 68098 MGI:1915348 -0.887624 Mpc1 55951 MGI:1915240 -0.89204 H3f3a 15078 MGI:1097686 -0.894515 Tpgs1 110012 MGI:106618 -0.895456 Bri3bp 76809 MGI:1924059 -0.896259 Ppm1k 243382 MGI:2442111 -0.896436 Mipep 70478 MGI:1917728 -0.897191 Evi5l 213027 MGI:2442167 -0.902367 Emc10 69683 MGI:1916933 -0.904249 Pmvk 68603 MGI:1915853 -0.906877 Dock10 210293 MGI:2146320 -0.910914 Homer1 26556 MGI:1347345 -0.914274 Hsd17b12 56348 MGI:1926967 -0.917034 Ormdl2 66844 MGI:1914094 -0.930451 Sys1 66460 MGI:1913710 -0.934018 Esco1 77805 MGI:1925055 -0.934995 Wdr61 66317 MGI:1917493 -0.935785 Srebf2 20788 MGI:107585 -0.942197 Mtch2 56428 MGI:1929260 -0.952588 Hmgn3 94353 MGI:2138069 -0.954304 Tma7 66167 MGI:1913417 -0.964423 Bpgm 12183 MGI:1098242 -0.970073 Rps27l 67941 MGI:1915191 -0.976009 Tmem33 67878 MGI:1915128 -0.976237 N4bp2l2 381695 MGI:2687207 -0.980602 Scp2 20280 MGI:98254 -1.000501 Ippk 75678 MGI:1922928 -1.002815 Rnf141 67150 MGI:1914400 -1.003368 Rpa3 68240 MGI:1915490 -1.00923 Trp53inp2 68728 MGI:1915978 -1.009848 Gng10 14700 MGI:1336169 -1.01765 Add1 11518 MGI:87918 -1.022322 Kbtbd3 69149 MGI:1916399 -1.025281 Ppdpf 66496 MGI:1913746 -1.038666 Helb 117599 MGI:2152895 -1.041155 Arap2 212285 MGI:2684416 -1.059726 Calm1 12313 MGI:88251 -1.066683 Tex9 21778 MGI:1201610 -1.06847 Rpl13a 22121 MGI:1351455 -1.068581 Morn2 378462 MGI:2674071 -1.083949 Cox7c 12867 MGI:103226 -1.086245 Cdh10 320873 MGI:107436 -1.091154 Grik3 14807 MGI:95816 -1.096116 Tgds 76355 MGI:1923605 -1.13047 Rbms2 56516 MGI:1861776 -1.148219 Wdr5b 69544 MGI:1916794 -1.15573 Gm13889 620695 MGI:3652053 -1.155855 Arl8a 68724 MGI:1915974 -1.159334 Poglut1 224143 MGI:2444232 -1.162409 Ankrd39 109346 MGI:1914816 -1.163186 Gm14305 100043387 MGI:3709632 -1.168092 B130055M24Rik654803 MGI:3590645 -1.177872 Dynll1 56455 MGI:1861457 -1.182253 Sc5d 235293 MGI:1353611 -1.18916 Zfyve28 231125 MGI:2684992 -1.192516 Gm8186 666609 MGI:3643110 -1.200735 Psmb5 19173 MGI:1194513 -1.219435 2210418O10Rik100504263 MGI:1924208 -1.226801 Slmap 83997 MGI:1933549 -1.235679 1810037I17Rik 67704 MGI:1914954 -1.239344 Gabrg1 14405 MGI:103156 -1.243188 Robo2 268902 MGI:1890110 -1.247224 Prkcb 18751 MGI:97596 -1.24736 Rgs2 19735 MGI:1098271 -1.251786 Rab31 106572 MGI:1914603 -1.252899 Srl 106393 MGI:2146620 -1.257584 Fzd3 14365 MGI:108476 -1.25838 En2 13799 MGI:95390 -1.262316 Rsrc2 208606 MGI:1913489 -1.268936 Endod1 71946 MGI:1919196 -1.277513 Lsm5 66373 MGI:1913623 -1.279014 Cd81 12520 MGI:1096398 -1.286331 Pik3r3 18710 MGI:109277 -1.28678 Zmat3 22401 MGI:1195270 -1.30471 Pcyox1 66881 MGI:1914131 -1.307937 Stk39 53416 MGI:1858416 -1.322558 Txndc16 70561 MGI:1917811 -1.329567 Rnf14 56736 MGI:1929668 -1.332137 Usp45 77593 MGI:101850 -1.336276 Ccng1 12450 MGI:102890 -1.33679 Tmem123 71929 MGI:1919179 -1.353933 Bnip3 12176 MGI:109326 -1.358403 Ppp1r16b 228852 MGI:2151841 -1.361171 Bicd2 76895 MGI:1924145 -1.363382 Abi1 11308 MGI:104913 -1.373676 Pcdhb2 93873 MGI:2136735 -1.386272 Qdpr 110391 MGI:97836 -1.392154 Plcg2 234779 MGI:97616 -1.400842 Trp53inp1 60599 MGI:1926609 -1.418522 Rgs7 24012 MGI:1346089 -1.419295 Hnrnph2 56258 MGI:1201779 -1.427725 Acss2 60525 MGI:1890410 -1.428001 Ell2 192657 MGI:2183438 -1.428041 Cdk2ap1 13445 MGI:1202069 -1.429998 Pcdh9 211712 MGI:1306801 -1.453956 Usp2 53376 MGI:1858178 -1.470023 Myo6 17920 MGI:104785 -1.470983 Nudt4 71207 MGI:1918457 -1.473528 Secisbp2l 70354 MGI:1917604 -1.475289 Mcam 84004 MGI:1933966 -1.483554 Carhsp1 52502 MGI:1196368 -1.493228 Mapk8ip1 19099 MGI:1309464 -1.49754 Trim13 66597 MGI:1913847 -1.514417 Inppl1 16332 MGI:1333787 -1.515124 Olig1 50914 MGI:1355334 -1.516766 Mlx 21428 MGI:108398 -1.517223 Cic 71722 MGI:1918972 -1.518599 Gm10182 100041826 MGI:3704327 -1.528295 Foxj1 15223 MGI:1347474 -1.533841 Zfp563 240068 MGI:2677168 -1.5346 Lss 16987 MGI:1336155 -1.534781 Mvk 17855 MGI:107624 -1.537605 B3gat2 280645 MGI:2389490 -1.540232 Ralgps1 241308 MGI:1922008 -1.542154 Lin7a 108030 MGI:2135609 -1.543172 Ufc1 66155 MGI:1913405 -1.565737 Zfp420 233058 MGI:2444666 -1.566104 Ube2v2 70620 MGI:1917870 -1.572818 Dip2a 64451 MGI:2385920 -1.580516 Sema4g 26456 MGI:1347047 -1.585468 Gm3055 100040944 MGI:3809197 -1.590236 Fam155a 270028 MGI:2142765 -1.590993 Agrn 11603 MGI:87961 -1.59394 Pcna-ps2 18540 MGI:97505 -1.594677 Bend6 320705 MGI:2444572 -1.596988 Actb 11461 MGI:87904 -1.600078 Pea15a 18611 MGI:104799 -1.602227 Hsd17b7 15490 MGI:1330808 -1.616208 Hmgcr 15357 MGI:96159 -1.62144 Tprn 97031 MGI:2139535 -1.635918 Dnm3 103967 MGI:1341299 -1.636796 Stard4 170459 MGI:2156764 -1.637243 3222401L13Rik105246409 MGI:2444186 -1.641977 Insig1 231070 MGI:1916289 -1.645176 Spef1 70997 MGI:3513546 -1.645374 Sqle 20775 MGI:109296 -1.65203 Cpox 12892 MGI:104841 -1.657563 Actn4 60595 MGI:1890773 -1.661049 Thsd4 207596 MGI:2672033 -1.6654 Klhl13 67455 MGI:1914705 -1.666097 Arrdc3 105171 MGI:2145242 -1.672799 Lcorl 209707 MGI:2651932 -1.673244 Tmod2 50876 MGI:1355335 -1.67634 Tubb4a 22153 MGI:107848 -1.680694 Dpagt1 13478 MGI:1196396 -1.684589 Gm15459 727711 MGI:3705702 -1.688663 Ctso 229445 MGI:2139628 -1.698397 Rap1a 109905 MGI:97852 -1.703443 Zbtb16 235320 MGI:103222 -1.707403 Kcnq3 110862 MGI:1336181 -1.721856 6530402F18Rik76220 MGI:1923470 -1.725627 Celsr3 107934 MGI:1858236 -1.735379 Cyp51 13121 MGI:106040 -1.745672 Mvd 192156 MGI:2179327 -1.747864 Tmem163 72160 MGI:1919410 -1.749429 Enoph1 67870 MGI:1915120 -1.753835 Tspan9 109246 MGI:1924558 -1.754465 Zfp422 67255 MGI:1914505 -1.762652 Acat2 110460 MGI:87871 -1.763494 Slc24a2 76376 MGI:1923626 -1.768879 Ehd3 57440 MGI:1928900 -1.769447 Tm7sf2 73166 MGI:1920416 -1.774137 Tmem98 103743 MGI:1923457 -1.775145 Col4a1 12826 MGI:88454 -1.790473 Rbm5 83486 MGI:1933204 -1.812913 Gramd3 107022 MGI:1914815 -1.825651 Sema6a 20358 MGI:1203727 -1.826344 Idh1 15926 MGI:96413 -1.832865 Galnt13 271786 MGI:2139447 -1.84079 Sorcs1 58178 MGI:1929666 -1.858687 Rnf122 68867 MGI:1916117 -1.868134 Nsdhl 18194 MGI:1099438 -1.870842 Atp8b1 54670 MGI:1859665 -1.871606 Nkain3 269513 MGI:2444830 -1.890727 Lpar6 67168 MGI:1914418 -1.893859 Gpsm1 67839 MGI:1915089 -1.89963 Josd2 66124 MGI:1913374 -1.906222 Rabl2 68708 MGI:1915958 -1.914357 Slc8a1 20541 MGI:107956 -1.932342 Plekhh1 211945 MGI:2144989 -1.952378 Rab3b 69908 MGI:1917158 -1.960335 Frmd5 228564 MGI:2442557 -1.969448 Phlda3 27280 MGI:1351485 -2.006082 Commd6 66200 MGI:1913450 -2.052969 Bach2 12014 MGI:894679 -2.05762 Phc1 13619 MGI:103248 -2.065565 Pon2 330260 MGI:106687 -2.0664 Smurf1 75788 MGI:1923038 -2.099556 Cacnb4 12298 MGI:103301 -2.099664 Unc5b 107449 MGI:894703 -2.102764 Entpd5 12499 MGI:1321385 -2.103093 Mbd5 109241 MGI:2138934 -2.103385 Fdps 110196 MGI:104888 -2.119133 Add3 27360 MGI:1351615 -2.132424 Mettl7a1 70152 MGI:1916523 -2.140434 Hs3st3b1 54710 MGI:1333853 -2.142399 St8sia4 20452 MGI:106018 -2.145575 Tssc4 56844 MGI:1861712 -2.1566 Adam22 11496 MGI:1340046 -2.169144 Ptprd 19266 MGI:97812 -2.177053 Cntn3 18488 MGI:99534 -2.183161 Ccp110 101565 MGI:2141942 -2.197874 Fgd6 13998 MGI:1261419 -2.198181 Fdft1 14137 MGI:102706 -2.212148 Tmem151a 381199 MGI:2147713 -2.212272 Cirbp 12696 MGI:893588 -2.21904 Ldlrap1 100017 MGI:2140175 -2.22158 Dph6 66632 MGI:1913882 -2.231698 Mtch1 56462 MGI:1929261 -2.233577 Nckap5 210356 MGI:2686394 -2.272013 Sema5a 20356 MGI:107556 -2.285303 Atxn1 20238 MGI:104783 -2.302899 Smad7 17131 MGI:1100518 -2.321438 Bcas1 76960 MGI:1924210 -2.324547 Ddc 13195 MGI:94876 -2.341043 Dst 13518 MGI:104627 -2.362173 Eps15 13858 MGI:104583 -2.362229 Kcnc1 16502 MGI:96667 -2.368797 Pick1 18693 MGI:894645 -2.371904 Galnt11 231050 MGI:2444392 -2.379636 Cyth2 19158 MGI:1334255 -2.385705 Sema6d 214968 MGI:2387661 -2.390413 Gapvd1 66691 MGI:1913941 -2.409901 Odf2 18286 MGI:1098824 -2.419754 Pcdha2 353234 MGI:2681880 -2.424246 Ano3 228432 MGI:3613666 -2.433609 Ephb1 270190 MGI:1096337 -2.436316 Gnb1 14688 MGI:95781 -2.449572 Slc25a4 11739 MGI:1353495 -2.449664 Gm13835 100038973 MGI:3650921 -2.458756 Gm12338 654359 MGI:3650622 -2.467241 Kcnj2 16518 MGI:104744 -2.475622 Mroh1 223658 MGI:2442558 -2.477553 Psmd13 23997 MGI:1345192 -2.487477 Rb1 19645 MGI:97874 -2.492537 Gpr149 229357 MGI:2443628 -2.494521 Ptgr1 67103 MGI:1914353 -2.501228 Pttg1 30939 MGI:1353578 -2.521092 Arl6 56297 MGI:1927136 -2.531987 Lpar1 14745 MGI:108429 -2.534674 Slc27a3 26568 MGI:1347358 -2.543298 Grm7 108073 MGI:1351344 -2.554933 Kit 16590 MGI:96677 -2.559397 Zfp747 269997 MGI:2443581 -2.566439 Ada 11486 MGI:87916 -2.572179 Psrc1 56742 MGI:1913099 -2.584627 Eml1 68519 MGI:1915769 -2.595375 Mbp 17196 MGI:96925 -2.599346 Zfp709 236193 MGI:2384299 -2.605936 Fnbp1 14269 MGI:109606 -2.619655 Hmgcs1 208715 MGI:107592 -2.631726 Tcf7l2 21416 MGI:1202879 -2.652201 Vps18 228545 MGI:2443626 -2.652294 Gm10259 100039592 MGI:3704211 -2.665744 Adra1d 11550 MGI:106673 -2.697756 Aspdh 68352 MGI:1915602 -2.710869 Idi1 319554 MGI:2442264 -2.717095 Eif4e2 26987 MGI:1914440 -2.724457 Uhrf1 18140 MGI:1338889 -2.730491 Fam107b 66540 MGI:1913790 -2.742204 Fam81a 76886 MGI:1924136 -2.746716 Cuedc2 67116 MGI:1914366 -2.749749 Nrxn1 18189 MGI:1096391 -2.753993 Pi4kb 107650 MGI:1334433 -2.757149 Arid2 77044 MGI:1924294 -2.758272 Adcy2 210044 MGI:99676 -2.760271 Lingo2 242384 MGI:2442298 -2.769888 Gstm1 14862 MGI:95860 -2.786301 Shroom2 110380 MGI:107194 -2.799639 Plp1 18823 MGI:97623 -2.80376 Trf 22041 MGI:98821 -2.808853 Gm5873 545826 MGI:3648385 -2.830393 Myo1e 71602 MGI:106621 -2.832209 Pgm2l1 70974 MGI:1918224 -2.843978 Jakmip3 74004 MGI:1921254 -2.845502 Gpr37 14763 MGI:1313297 -2.856247 Trrap 100683 MGI:2153272 -2.873988 Mapkapk3 102626 MGI:2143163 -2.889884 Tnfrsf19 29820 MGI:1352474 -2.895831 Paip2b 232164 MGI:2386865 -2.915855 Pank1 75735 MGI:1922985 -2.930691 Synpr 72003 MGI:1919253 -2.932085 Ing4 28019 MGI:107307 -2.933881 Gm10709 100039782 MGI:3642754 -2.936314 Mog 17441 MGI:97435 -2.951852 Gm10184 100043906 MGI:3704480 -2.958464 Bfsp2 107993 MGI:1333828 -2.961747 Itih3 16426 MGI:96620 -2.966904 Ldlr 16835 MGI:96765 -2.992425 Tspyl5 239364 MGI:2442458 -3.001303 Gm20482 102632136 MGI:5141947 -3.007663 Pcdhga9 93717 MGI:1935226 -3.008398 Txndc15 69672 MGI:1916922 -3.015824 Ift88 21821 MGI:98715 -3.019789 Zfp93 22755 MGI:107611 -3.025763 Tdrd3 219249 MGI:2444023 -3.036846 Dpysl5 65254 MGI:1929772 -3.038936 Grm5 108071 MGI:1351342 -3.063281 Cdc42ep2 104252 MGI:1929744 -3.088296 Atp11b 76295 MGI:1923545 -3.10318 Rad18 58186 MGI:1890476 -3.107496 Enpp6 320981 MGI:2445171 -3.114246 Tuba1a 22142 MGI:98869 -3.116232 Alox5 11689 MGI:87999 -3.122329 Nnt 18115 MGI:109279 -3.124323 Fam83d 71878 MGI:1919128 -3.133494 Prepl 213760 MGI:2441932 -3.133911 Gm9625 674597 MGI:3780033 -3.138272 Vstm2b 58188 MGI:1914525 -3.139427 Trim59 66949 MGI:1914199 -3.142701 Tubg2 103768 MGI:2144208 -3.151784 Dcdc2a 195208 MGI:2652818 -3.170367 Man1a 17155 MGI:104677 -3.17117 Pdia3 14827 MGI:95834 -3.181539 Elmod1 270162 MGI:3583900 -3.194235 S1pr5 94226 MGI:2150641 -3.194921 Cyp20a1 77951 MGI:1925201 -3.211655 Cln3 12752 MGI:107537 -3.215819 Rapgef3 223864 MGI:2441741 -3.235033 Kdm2a 225876 MGI:1354736 -3.243428 Acap3 140500 MGI:2153589 -3.258722 5031434C07Rik100503613 MGI:2442810 -3.274214 Smim1 68859 MGI:1916109 -3.281673 9530053A07Rik319482 MGI:2442118 -3.295336 Aqp4 11829 MGI:107387 -3.305628 Fbxo3 57443 MGI:1929084 -3.31035 9130019O22Rik78921 MGI:1926171 -3.320393 Abr 109934 MGI:107771 -3.324866 Map3k10 269881 MGI:1346879 -3.326493 Auts2 319974 MGI:1919847 -3.328442 D630036G22Rik442807 MGI:3045265 -3.329563 Dnajc6 72685 MGI:1919935 -3.361268 Gm20687 102634039 MGI:5313134 -3.371532 Gtpbp3 70359 MGI:1917609 -3.390378 Meis1 17268 MGI:104717 -3.392188 Rpl10a 19896 MGI:1343877 -3.406232 Lynx1 23936 MGI:1345180 -3.410565 S1pr3 13610 MGI:1339365 -3.415605 Moap1 64113 MGI:1915555 -3.423216 Igsf21 230868 MGI:2681842 -3.425713 Ephx1 13849 MGI:95405 -3.44745 2610507I01Rik 72203 MGI:1919453 -3.464713 Pde4a 18577 MGI:99558 -3.476366 Gm6100 619780 MGI:3644987 -3.484056 Tor1b 30934 MGI:1353605 -3.519311 Zfp882 382019 MGI:3642748 -3.522697 Rragc 54170 MGI:1858751 -3.538068 Gria1 14799 MGI:95808 -3.57705 Ncapd3 78658 MGI:2142989 -3.586854 Gm8730 667618 MGI:3644565 -3.605255 Eda2r 245527 MGI:2442860 -3.623697 Meg3 17263 MGI:1202886 -3.667739 Agtpbp1 67269 MGI:2159437 -3.697109 Arhgef10l 72754 MGI:1920004 -3.700112 Arc 11838 MGI:88067 -3.723796 Rpl29 19944 MGI:99687 -3.726058 Sulf1 240725 MGI:2138563 -3.733238 Zmym3 56364 MGI:1927231 -3.766522 Rian 75745 MGI:1922995 -3.817111 Ech1 51798 MGI:1858208 -3.827193 Gdpd3 68616 MGI:1915866 -3.890476 Car2 12349 MGI:88269 -3.942156 Pkp4 227937 MGI:109281 -3.988589 Plch2 269615 MGI:2443078 -3.991559 A230056P14Rik320845 MGI:2444856 -3.996043 Gm16233 100504497 MGI:3802088 -4.000219 Urod 22275 MGI:98916 -4.064324 Sirt2 64383 MGI:1927664 -4.103458 Zfp456 408065 MGI:3040694 -4.182077 Hapln2 73940 MGI:2137300 -4.336959 Obscn 380698 MGI:2681862 -4.457339 Thap1 73754 MGI:1921004 -4.474481 Pex5l 58869 MGI:1916672 -4.5 Gusb 110006 MGI:95872 -4.512385 Zzef1 195018 MGI:2444286 -4.531082 Cradd 12905 MGI:1336168 -4.61702 Abhd14a 68644 MGI:1915894 -4.692278 Itga2 16398 MGI:96600 -4.841992 Rpl34-ps1 619547 MGI:3704270 -4.864406 Csmd2 329942 MGI:2386401 -4.887078 Rps14 20044 MGI:98107 -4.995723 Gstk1 76263 MGI:1923513 -5.290676 Dlg3 53310 MGI:1888986 -5.334102 Tmem223 66836 MGI:1914086 -5.359521 Tshz3 243931 MGI:2442819 -5.365843 Gm6166 101056162 MGI:3645893 -5.484411 Nudt5 53893 MGI:1858232 -5.657261 Table S1: Thap1 +/+ Vs Thap1 -/- DEG - Common Genes Symbol Entrez Gene IDMGI Gene/Marker ID 1110034G24Rik 73747 MGI:1920997 1700012B15Rik 74173 MGI:1921423 1810043G02Rik 67884 MGI:1915134 2610507I01Rik 72203 MGI:1919453 6530402F18Rik 76220 MGI:1923470 9130019O22Rik 78921 MGI:1926171 A230056P14Rik 320845 MGI:2444856 Aars 234734 MGI:2384560 Aars2 224805 MGI:2681839 Aatf 56321 MGI:1929608 Abca6 76184 MGI:1923434 Abcb6 74104 MGI:1921354 Abhd14a 68644 MGI:1915894 Abr 109934 MGI:107771 Actb 11461 MGI:87904 Adam22 11496 MGI:1340046 Aebp1 11568 MGI:1197012 Afap1l1 106877 MGI:2147199 Agrn 11603 MGI:87961 Akt1s1 67605 MGI:1914855 Ano10 102566 MGI:2143103 Anxa6 11749 MGI:88255 Arrb1 109689 MGI:99473 Atic 108147 MGI:1351352 B130055M24Rik 654803 MGI:3590645 BC002163 170658 MGI:3612445 Bche 12038 MGI:894278 Bend6 320705 MGI:2444572 Bfsp2 107993 MGI:1333828 C1ql3 227580 MGI:2387350 C77080 97130 MGI:2140651 Cast 12380 MGI:1098236 Cd81 12520 MGI:1096398 Cdc42ep5 58804 MGI:1929745 Cdh18 320865 MGI:1344366 Cdk2ap1 13445 MGI:1202069 Cdk5rap3 80280 MGI:1933126 Celf4 108013 MGI:1932407 Chst5 56773 MGI:1931825 Clint1 216705 MGI:2144243 Cln3 12752 MGI:107537 Cmtm3 68119 MGI:2447162 Col16a1 107581 MGI:1095396 Col18a1 12822 MGI:88451 Col4a1 12826 MGI:88454 Cradd 12905 MGI:1336168 Csmd2 329942 MGI:2386401 Cuedc2 67116 MGI:1914366 Cyb5 109672 MGI:1926952 Cyb5r4 266690 MGI:2386848 D630036G22Rik 442807 MGI:3045265 Dct 13190 MGI:102563 Ddn 13199 MGI:108101 Dlg3 53310 MGI:1888986 Dock2 94176 MGI:2149010 Dpagt1 13478 MGI:1196396 Dph5 69740 MGI:1916990 Dpysl5 65254 MGI:1929772 Dst 13518 MGI:104627 Ech1 51798 MGI:1858208 Eda2r 245527 MGI:2442860 Efcab1 66793 MGI:1914043 Efs 13644 MGI:105311 Ehd3 57440 MGI:1928900 Ell2 192657 MGI:2183438 Elp3 74195 MGI:1921445 Emc10 69683 MGI:1916933 Epb4.1l1 13821 MGI:103010 Epb4.1l3 13823 MGI:103008 Epb4.1l4b 54357 MGI:1859149 Ephb1 270190 MGI:1096337 Ero1l 50527 MGI:1354385 Erp27 69187 MGI:1916437 Evi5l 213027 MGI:2442167 Exoc4 20336 MGI:1096376 Ezh1 14055 MGI:1097695 Fam101b 76566 MGI:1923816 Fam107b 66540 MGI:1913790 Fam114a1 68303 MGI:1915553 Fam117a 215512 MGI:2144564 Fam174b 100038347 MGI:3698178 Fam212b 109050 MGI:1923497 Fam73a 215708 MGI:1924567 Fggy 75578 MGI:1922828 Fibp 58249 MGI:1926233 Fndc3c1 333564 MGI:2685630 Gaa 14387 MGI:95609 Gareml 242915 MGI:2685290 Gas5 14455 MGI:95659 Gdnf 14573 MGI:107430 Gdpd3 68616 MGI:1915866 Glce 93683 MGI:2136405 Gm10439 382243 MGI:3710525 Gm10709 100039782 MGI:3642754 Gm11520 102640811 MGI:3650534 Gm11868 667251 MGI:3650507 Gm12250 631323 MGI:3649299 Gm12663 105274305 MGI:3652168 Gm12750 102635290 MGI:3651956 Gm13456 666531 MGI:3651389 Gm13835 100038973 MGI:3650921 Gm13841 665032 MGI:3650890 Gm14150 100043840 MGI:3651006 Gm15051 105242658 MGI:3705155 Gm15085 100039934 MGI:3712210 Gm15093 100039890 MGI:3712496 Gm15459 727711 MGI:3705702 Gm20482 102632136 MGI:5141947 Gm2a 14667 MGI:95762 Gm6166 101056162 MGI:3645893 Gm6768 627557 MGI:3648259 Gm7887 666005 MGI:3648251 Gm8730 667618 MGI:3644565 Gm9625 674597 MGI:3780033 Gnb1 14688 MGI:95781 Gpr176 381413 MGI:2685858 Grb10 14783 MGI:103232 Grik3 14807 MGI:95816 Grm5 108071 MGI:1351342 Gstk1 76263 MGI:1923513 Gt(ROSA)26Sor 14910 MGI:104735 Gusb 110006 MGI:95872 Hapln2 73940 MGI:2137300 Hemk1 69536 MGI:1916786 Hmgcs1 208715 MGI:107592 Homer1 26556 MGI:1347345 Hs3st3b1 54710 MGI:1333853 Hs6st2 50786 MGI:1354959 Hsd17b12 56348 MGI:1926967 Hyi 68180 MGI:1915430 Idh1 15926 MGI:96413 Ift20 55978 MGI:1915585 Igsf21 230868 MGI:2681842 Ing4 28019 MGI:107307 Ippk 75678 MGI:1922928 Irgm1 15944 MGI:107567 Itga2 16398 MGI:96600 Itgb3 16416 MGI:96612 Jmjd6 107817 MGI:1858910 Kcna1 16485 MGI:96654 Kcnk1 16525 MGI:109322 Klhl13 67455 MGI:1914705 Kremen1 84035 MGI:1933988 Ldoc1l 223732 MGI:2675858 Lhpp 76429 MGI:1923679 Lrrc16a 68732 MGI:1915982 Luzp4 434865 MGI:3708816 Man1a 17155 MGI:104677 Man2a2 140481 MGI:2150656 Mapk8ip1 19099 MGI:1309464 Mapt 17762 MGI:97180 Mcam 84004 MGI:1933966 Mfge8 17304 MGI:102768 Mical1 171580 MGI:2385847 Mkx 210719 MGI:2687286 Mpg 268395 MGI:97073 Mpi 110119 MGI:97075 Mxra8 74761 MGI:1922011 Myo1e 71602 MGI:106621 Mzt1 76789 MGI:1924039 N4bp2l2 381695 MGI:2687207 Nckap5 210356 MGI:2686394 Ndfip2 76273 MGI:1923523 Nid1 18073 MGI:97342 Ninj2 29862 MGI:1352751 Nkain3 269513 MGI:2444830 Npepl1 228961 MGI:2448523 Npm1 18148 MGI:106184 Nptx1 18164 MGI:107811 Nrxn1 18189 MGI:1096391 Obscn 380698 MGI:2681862 Ott 18422 MGI:107573 Pax9 18511 MGI:97493 Pcdh8 18530 MGI:1306800 Pcdh9 211712 MGI:1306801 Pcdha2 353234 MGI:2681880 Pcdhb2 93873 MGI:2136735 Pcdhga9 93717 MGI:1935226 Pcolce2 76477 MGI:1923727 Pea15a 18611 MGI:104799 Pfkl 18641 MGI:97547 Pigs 276846 MGI:2687325 Plch1 269437 MGI:2683547 Plch2 269615 MGI:2443078 Plin2 11520 MGI:87920 Poglut1 224143 MGI:2444232 Ppfibp1 67533 MGI:1914783 Ppp2r3c 59032 MGI:1930009 Prepl 213760 MGI:2441932 Prokr1 58182 MGI:1929676 Prpsap1 67763 MGI:1915013 Psmb5 19173 MGI:1194513 Pter 19212 MGI:107372 Pttg1 30939 MGI:1353578 Pyroxd2 74580 MGI:1921830 Rab34 19376 MGI:104606 Rabep1 54189 MGI:1860236 Ramp2 54409 MGI:1859650 Ranbp17 66011 MGI:1929706 Rars 104458 MGI:1914297 Rasgef1a 70727 MGI:1917977 Rgcc 66214 MGI:1913464 Rian 75745 MGI:1922995 Rnaseh2a 69724 MGI:1916974 Robo2 268902 MGI:1890110 Rpl29 19944 MGI:99687 Rpl3-ps1 100043000 MGI:3644217 Rpl34-ps1 619547 MGI:3704270 Rsph9 75564 MGI:1922814 S1pr5 94226 MGI:2150641 Sc4mol 66234 MGI:1913484 Scamp2 24044 MGI:1346518 Scarf1 380713 MGI:2449455 Scd2 20250 MGI:98240 Secisbp2l 70354 MGI:1917604 Sema7a 20361 MGI:1306826 Sfmbt2 353282 MGI:2447794 Sh3tc2 225608 MGI:2444417 Slc26a2 13521 MGI:892977 Slc2a1 20525 MGI:95755 Slc39a11 69806 MGI:1917056 Slc39a14 213053 MGI:2384851 Slc8a1 20541 MGI:107956 Smoc1 64075 MGI:1929878 Snrnp35 76167 MGI:1923417 Sorcs1 58178 MGI:1929666 Sparc 20692 MGI:98373 Spef1 70997 MGI:3513546 Sptb 20741 MGI:98387 Sqstm1 18412 MGI:107931 St3gal6 54613 MGI:1888707 Sulf1 240725 MGI:2138563 Syt4 20983 MGI:101759 Tbc1d23 67581 MGI:1914831 Tbrg1 21376 MGI:1100877 Tex2 21763 MGI:102465 Tgfb3 21809 MGI:98727 Thap1 73754 MGI:1921004 Tmed3 66111 MGI:1913361 Tmem117 320709 MGI:2444580 Tmem163 72160 MGI:1919410 Tmem180 75146 MGI:1922396 Tmem2 83921 MGI:1890373 Tmem223 66836 MGI:1914086 Tmod2 50876 MGI:1355335 Tpbg 21983 MGI:1341264 Tprn 97031 MGI:2139535 Traf4 22032 MGI:1202880 Trf 22041 MGI:98821 Trmt1 212528 MGI:1289155 Trmt1 72026 MGI:1919276 Trove2 20822 MGI:106652 Trp53 22059 MGI:98834 Tshz3 243931 MGI:2442819 Tspan9 109246 MGI:1924558 Tsr1 104662 MGI:2144566 Tssc4 56844 MGI:1861712 Tuba1a 22142 MGI:98869 Tuba1c 22146 MGI:1095409 Tubg2 103768 MGI:2144208 Txndc15 69672 MGI:1916922 Ucp2 22228 MGI:109354 Ufc1 66155 MGI:1913405 Uggt2 66435 MGI:1913685 Usp54 78787 MGI:1926037 Wdr5b 69544 MGI:1916794 Zak 65964 MGI:2443258 Zbtb38 245007 MGI:2442866 Zfp14 243906 MGI:99160 Zfp429 72807 MGI:1920057 Zfp456 408065 MGI:3040694 Zfp563 240068 MGI:2677168 Zfp709 236193 MGI:2384299 Zfp747 269997 MGI:2443581 Zfp882 382019 MGI:3642748 Zfyve28 231125 MGI:2684992 Table S2: DEG - DIV 2 - Analysis GO - Biological GO biological process complete upload_1 (fold Enrichment) upload_1 (raw P-value) heparan sulfate proteoglycan metabolic process (GO:0030201) 9.15 4.35E-04 DNA damage response, signal transduction by p53 class mediator (GO:0030330) 7.21 3.58E-04 membrane biogenesis (GO:0044091) 6.79 4.77E-04 regulation of filopodium assembly (GO:0051489) 5.85 3.64E-04 negative regulation of actin filament polymerization (GO:0030837) 5.85 3.64E-04 negative regulation of protein depolymerization (GO:1901880) 5.67 6.67E-05 plasma membrane organization (GO:0007009) 5.32 1.04E-04 regulation of protein tyrosine kinase activity (GO:0061097) 5.32 1.04E-04 negative regulation of protein polymerization (GO:0032272) 5.3 2.56E-04 positive regulation of phagocytosis (GO:0050766) 5.13 3.15E-04 negative regulation of protein complex disassembly (GO:0043242) 5.09 1.41E-04 regulation of protein depolymerization (GO:1901879) 4.49 3.30E-04 negative regulation of cytoskeleton organization (GO:0051494) 4.47 4.03E-06 regulation of stress fiber assembly (GO:0051492) 4.27 4.63E-04 extracellular matrix organization (GO:0030198) 4.25 2.19E-07 extracellular structure organization (GO:0043062) 4.23 2.37E-07 myelination (GO:0042552) 4.13 2.89E-04 negative regulation of supramolecular fiber organization (GO:1902904) 4.1 4.06E-05 ensheathment of neurons (GO:0007272) 4.01 3.65E-04 regulation of actin filament bundle assembly (GO:0032231) 4.01 3.65E-04 axon ensheathment (GO:0008366) 4.01 3.65E-04 regulation of protein complex disassembly (GO:0043244) 3.81 5.28E-04 positive regulation of endocytosis (GO:0045807) 3.64 6.87E-05 protein localization to plasma membrane (GO:0072659) 3.56 4.79E-05 positive regulation of peptidyl-tyrosine phosphorylation (GO:0050731) 3.52 3.12E-05 protein localization to cell periphery (GO:1990778) 3.33 5.78E-05 negative regulation of neuron apoptotic process (GO:0043524) 3.26 1.99E-04 positive regulation of MAP kinase activity (GO:0043406) 3.1 7.76E-05 angiogenesis (GO:0001525) 3.07 5.14E-06 positive regulation of protein kinase activity (GO:0045860) 2.96 1.66E-07 regulation of neuron apoptotic process (GO:0043523) 2.95 5.65E-05 negative regulation of cell cycle process (GO:0010948) 2.94 5.28E-04 negative regulation of locomotion (GO:0040013) 2.88 3.13E-05 regulation of peptidyl-tyrosine phosphorylation (GO:0050730) 2.88 1.13E-04 regulation of actin filament organization (GO:0110053) 2.84 2.04E-04 positive regulation of kinase activity (GO:0033674) 2.81 3.25E-07 positive regulation of protein serine/threonine kinase activity (GO:0071902) 2.78 5.03E-05 regulation of endocytosis (GO:0030100) 2.77 2.71E-04 regulation of supramolecular fiber organization (GO:1902903) 2.76 3.71E-05 positive regulation of transferase activity (GO:0051347) 2.62 4.45E-07 regulation of MAP kinase activity (GO:0043405) 2.6 2.58E-04 protein localization to membrane (GO:0072657) 2.56 1.05E-04 negative regulation of organelle organization (GO:0010639) 2.56 1.09E-04 blood vessel morphogenesis (GO:0048514) 2.54 4.87E-05 axonogenesis (GO:0007409) 2.5 2.95E-04 cell projection morphogenesis (GO:0048858) 2.47 2.96E-05 modulation of chemical synaptic transmission (GO:0050804) 2.45 1.87E-04 regulation of trans-synaptic signaling (GO:0099177) 2.45 1.87E-04 neuron projection morphogenesis (GO:0048812) 2.44 4.87E-05 regulation of cytoskeleton organization (GO:0051493) 2.43 2.57E-05 plasma membrane bounded cell projection morphogenesis (GO:0120039) 2.41 5.62E-05 carbohydrate metabolic process (GO:0005975) 2.4 1.57E-04 cell morphogenesis involved in neuron differentiation (GO:0048667) 2.39 1.66E-04 cell adhesion (GO:0007155) 2.39 1.20E-07 chemical synaptic transmission (GO:0007268) 2.39 4.59E-04 anterograde trans-synaptic signaling (GO:0098916) 2.39 4.59E-04 regulation of neuron death (GO:1901214) 2.38 4.70E-04 biological adhesion (GO:0022610) 2.36 1.60E-07 cell part morphogenesis (GO:0032990) 2.34 6.07E-05 trans-synaptic signaling (GO:0099537) 2.34 5.49E-04 blood vessel development (GO:0001568) 2.33 5.12E-05 positive regulation of phosphorylation (GO:0042327) 2.33 8.19E-09 synaptic signaling (GO:0099536) 2.33 5.80E-04 regulation of kinase activity (GO:0043549) 2.33 7.89E-07 positive regulation of MAPK cascade (GO:0043410) 2.3 1.14E-04 positive regulation of protein phosphorylation (GO:0001934) 2.28 5.25E-08 regulation of transferase activity (GO:0051338) 2.26 3.92E-07 regulation of protein kinase activity (GO:0045859) 2.25 9.59E-06 positive regulation of phosphorus metabolic process (GO:0010562) 2.24 9.82E-09 positive regulation of phosphate metabolic process (GO:0045937) 2.24 9.82E-09 regulation of cellular response to stress (GO:0080135) 2.23 3.46E-05 cardiovascular system development (GO:0072358) 2.22 6.42E-05 cell morphogenesis involved in differentiation (GO:0000904) 2.22 1.17E-04 vasculature development (GO:0001944) 2.21 9.37E-05 positive regulation of nervous system development (GO:0051962) 2.21 5.87E-05 neuron projection development (GO:0031175) 2.2 2.41E-05 neuron development (GO:0048666) 2.14 6.48E-06 positive regulation of catalytic activity (GO:0043085) 2.06 1.13E-06 regulation of cellular component biogenesis (GO:0044087) 2.06 9.90E-06 positive regulation of protein modification process (GO:0031401) 2.04 4.86E-07 cytoskeleton organization (GO:0007010) 2.04 9.41E-06 positive regulation of cellular component organization (GO:0051130) 2.02 2.19E-07 Table S2: DEG - DIV 2 - Analysis GO - Molecular GO molecular function complete upload_1 (fold Enrichment)upload_1 (raw P-value) extracellular matrix binding (GO:0050840) 6.18 3.67E-05 molecular adaptor activity (GO:0060090) 3.9 3.41E-05 cell adhesion molecule binding (GO:0050839) 2.68 1.86E-06 Ras GTPase binding (GO:0017016) 2.64 1.54E-05 small GTPase binding (GO:0031267) 2.54 4.87E-05 GTPase binding (GO:0051020) 2.52 5.55E-06 actin binding (GO:0003779) 2.32 2.29E-04 cytoskeletal protein binding (GO:0008092) 2.24 2.72E-07 protein domain specific binding (GO:0019904) 2.09 1.82E-05 protein complex binding (GO:0032403) 2.09 2.87E-06 macromolecular complex binding (GO:0044877) 2.03 7.68E-07 protein kinase binding (GO:0019901) 2.03 1.63E-04 kinase binding (GO:0019900) 2.02 8.27E-05 Table S2: DEG - DIV 2 - Analysis DAVID - Biological Term PValue Fold Enrichment GO:0007155~cell adhesion 7.92E-05 2.25045116 GO:0043524~negative regulation of neuron apoptotic process 4.78E-04 3.1834507 GO:0001934~positive regulation of protein phosphorylation 5.70E-04 2.96594786 GO:0050885~neuromuscular process controlling balance 0.001004748 5.01824742 GO:0030198~extracellular matrix organization 0.001173996 3.51057221 GO:0043523~regulation of neuron apoptotic process 0.001914413 6.6149625 GO:0090307~mitotic spindle assembly 0.002503546 6.23696465 GO:0001525~angiogenesis 0.002558819 2.43563473 GO:0007229~integrin-mediated signaling pathway 0.004021364 3.52086714 GO:0007156~homophilic cell adhesion via plasma membrane adhesion0.005401737 molecules 2.67845107 GO:0007160~cell-matrix adhesion 0.005530659 3.73151731 GO:0019915~lipid storage 0.005949087 6.73746181 GO:0007010~cytoskeleton organization 0.007847175 3.14846773 GO:0007569~cell aging 0.008709112 6.06371563 GO:0051491~positive regulation of filopodium assembly 0.009786964 5.8681119 GO:0050766~positive regulation of phagocytosis 0.009877711 4.54778672 GO:0030855~epithelial cell differentiation 0.010052061 3.80113517 Table S2: DEG - DIV 2-4 Common - Analysis GO - Biological GO biological process complete upload_1 (foldupload_1 Enrichment) (raw P-value) cell adhesion (GO:0007155) 2.92 4.04E-06 biological adhesion (GO:0022610) 2.88 4.97E-06 anatomical structure development (GO:0048856) 1.57 5.34E-06 developmental process (GO:0032502) 1.54 6.17E-06 Table S2: DEG - DIV 2-4 Common - Analysis DAVID - Molecular Function Term PValue Fold Enrichment GO:0050840~extracellular matrix binding 0.00372 12.6511965 GO:0030506~ankyrin binding 0.022921 12.6511965 GO:0005518~collagen binding 0.004343 7.50494709 GO:0000049~tRNA binding 0.019594 6.94575495 GO:0016853~isomerase activity 0.009648 4.62043699 GO:0016798~hydrolase activity, acting on glycosyl bonds 0.05759 4.54145516 GO:0005178~integrin binding 0.026289 4.42791878 GO:0003924~GTPase activity 0.031223 2.96607 GO:0005509~calcium ion binding 1.22E-04 2.66055206 Table S2: DEG - DIV 2-4 Common - Analysis DAVID - Biological Function Term PValue Fold Enrichment GO:0007155~cell adhesion 1.61E-04 3.032545751 GO:0050885~neuromuscular process controlling balance 5.36E-04 8.950008249 GO:0031589~cell-substrate adhesion 0.001268963 18.21405188 GO:0032967~positive regulation of collagen biosynthetic process 0.003209231 13.31026868 GO:0003094~glomerular filtration 0.004495224 28.83891547 GO:0032836~glomerular basement membrane development 0.004495224 28.83891547 GO:0086036~regulation of cardiac muscle cell membrane potential 0.004495224 28.83891547 GO:0007216~G-protein coupled glutamate receptor signaling pathway 0.004495224 28.83891547 GO:0030198~extracellular matrix organization 0.010252677 4.553512969 GO:0007156~homophilic cell adhesion via plasma membrane adhesion molecules0.011533901 3.715443097 GO:0033627~cell adhesion mediated by integrin 0.012529804 17.30334928 GO:0030968~endoplasmic reticulum unfolded protein response 0.017753172 7.209728868 GO:0002687~positive regulation of leukocyte migration 0.026153649 11.79773815 GO:0071456~cellular response to hypoxia 0.031144884 4.199842059 GO:0031398~positive regulation of protein ubiquitination 0.031795035 5.767783094 GO:0007010~cytoskeleton organization 0.032109147 4.159458962 GO:0005975~carbohydrate metabolic process 0.032118247 2.939889441 GO:0030001~metal ion transport 0.033212558 10.38200957 GO:0006419~alanyl-tRNA aminoacylation 0.034115877 57.67783094 GO:0007420~brain development 0.03909216 2.803783449 GO:0008152~metabolic process 0.04226356 2.055473457 GO:0006664~glycolipid metabolic process 0.045228432 43.25837321 GO:0001937~negative regulation of endothelial cell proliferation 0.04639824 8.651674641 GO:0007268~chemical synaptic transmission 0.048881825 3.018026038 GO:0043523~regulation of neuron apoptotic process 0.05507862 7.865158765 GO:0010936~negative regulation of macrophage cytokine production 0.056213745 34.60669856 GO:0033591~response to L-ascorbic acid 0.056213745 34.60669856 Table S3: THAP1 regulated genes common to ECM metabolism MGI Gene/ Entrez Input Name Marker ID Gene ID Gaa MGI:95609 glucosidase, alpha, acid 14387 solute carrier family 2 (facilitated glucose Slc2a1 MGI:95755 20525 transporter), member 1 solute carrier family 26 (sulfate transporter), Slc26a2 MGI:892977 13521 member 2 St3gal6 MGI:1888707 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 54613 Agrn MGI:87961 agrin 11603 Glce MGI:2136405 glucuronyl C5-epimerase 93683 Gusb MGI:95872 glucuronidase, beta 110006 Hmmr MGI:104667 hyaluronan mediated motility receptor (RHAMM) 15366 Hexa MGI:96073 hexosaminidase A 15211 Hs6st1 MGI:1354958 heparan sulfate 6-O-sulfotransferase 1 50785 heparan sulfate (glucosamine) 3-O- Hs3st3b1 MGI:1333853 54710 sulfotransferase 3B1 Phka1 MGI:97576 phosphorylase kinase alpha 1 18679 Hs6st2 MGI:1354959 heparan sulfate 6-O-sulfotransferase 2 50786 Chsy3 MGI:1926173 chondroitin sulfate synthase 3 78923 carbohydrate (N-acetylglucosamine 6-O) Chst5 MGI:1931825 56773 sulfotransferase 5 Sord MGI:98266 sorbitol dehydrogenase 20322 Pfkl MGI:97547 phosphofructokinase, liver, B-type 18641 Eno2 MGI:95394 enolase 2, gamma neuronal 13807 Cd63 MGI:99529 CD63 antigen 12512 Fzd8 MGI:108460 frizzled class receptor 8 14370 Ctnnb1 MGI:88276 catenin (cadherin associated protein), beta 1 12387 Msn MGI:97167 moesin 17698 Trp53 MGI:98834 transformation related protein 53 22059 Ptk2 MGI:95481 PTK2 protein tyrosine kinase 2 14083 Itga2 MGI:96600 integrin alpha 2 16398 Flna MGI:95556 filamin, alpha 192176 Actb MGI:87904 actin, beta 11461 Erbb3 MGI:95411 erb-b2 receptor tyrosine kinase 3 13867 Vav3 MGI:1888518 vav 3 oncogene 57257 Itgb3 MGI:96612 integrin beta 3 16416 Itpr2 MGI:99418 inositol 1,4,5-triphosphate receptor 2 16439 Mdm2 MGI:96952 transformed mouse 3T3 cell double minute 2 17246 Extl3 MGI:1860765 exostosin-like glycosyltransferase 3 54616 Nrxn1 MGI:1096391 neurexin I 18189 P4hb MGI:97464 prolyl 4-hydroxylase, beta polypeptide 18453 Nid1 MGI:97342 nidogen 1 18073 Tgfb3 MGI:98727 transforming growth factor, beta 3 21809 Capn7 MGI:1338030 calpain 7 12339 Timp2 MGI:98753 tissue inhibitor of metalloproteinase 2 21858 Col16a1 MGI:1095396 collagen, type XVI, alpha 1 107581 Sparc MGI:98373 secreted acidic cysteine rich glycoprotein 20692 Pcolce2 MGI:1923727 procollagen C-endopeptidase enhancer 2 76477 Table S4: Primer sequences used for genotyping Gene Forward Reverse

Thap1 GCATAGGACAGAGCCTTTCAG GATGCCAATACCTGATTGGAG

TGCTGGGTGTTGGAAAATAA

Cre CTAGGCCACAGAATTGAAAGATCT GTAGGTGGAAATTCTAGCATCATCC

GCGGTCTGGCAGTAAAAACTATC GTGAAACAGCATTGCTGTCACTT

TgGUS CTA GGC CAC AGA ATT GAA AGA TCT GTA GGT GGA AAT TCT AGC ATC ATC C

CTG TGG CTG TCA CCA AGA GC GGA CAC TCA TCG ATG ACC AC