Supplementary Table S1. Genes Printed in the HC5 Microarray Employed in the Screening Phase of the Present Work

Home , CCDC180, EIF2B3, EIF3K, EIF3S6, GABA transporter type 1, OR2C3

Supplementary material Ann Rheum Dis

Supplementary Table S1. Genes printed in the HC5 microarray employed in the screening phase of the present work. CloneID Plate Position Well Length GeneSymbol GeneID Accession Description Vector 692672 HsxXG013989 2 B01 STK32A 202374 null serine/threonine kinase 32A pANT7_cGST 692675 HsxXG013989 3 C01 RPS10-NUDT3 100529239 null RPS10-NUDT3 readthrough pANT7_cGST 692678 HsxXG013989 4 D01 SPATA6L 55064 null spermatogenesis associated 6-like pANT7_cGST 692679 HsxXG013989 5 E01 ATP1A4 480 null ATPase, Na+/K+ transporting, alpha 4 polypeptide pANT7_cGST 692689 HsxXG013989 6 F01 ZNF816-ZNF321P 100529240 null ZNF816-ZNF321P readthrough pANT7_cGST 692691 HsxXG013989 7 G01 NKAIN1 79570 null Na+/K+ transporting ATPase interacting 1 pANT7_cGST 693155 HsxXG013989 8 H01 TNFSF12-TNFSF13 407977 NM_172089 TNFSF12-TNFSF13 readthrough pANT7_cGST 693161 HsxXG013989 9 A02 RAB12 201475 NM_001025300 RAB12, member RAS oncogene family pANT7_cGST 693169 HsxXG013989 10 B02 SYN1 6853 NM_133499 synapsin I pANT7_cGST 693176 HsxXG013989 11 C02 GJD3 125111 NM_152219 gap junction protein, delta 3, 31.9kDa pANT7_cGST 693181 HsxXG013989 12 D02 CHCHD10 400916 null coiled-coil-helix-coiled-coil-helix domain containing 10 pANT7_cGST 693184 HsxXG013989 13 E02 IDNK 414328 null idnK, gluconokinase homolog (E. coli) pANT7_cGST 693187 HsxXG013989 14 F02 LYPD6B 130576 null LY6/PLAUR domain containing 6B pANT7_cGST 693189 HsxXG013989 15 G02 C8orf86 389649 null chromosome 8 open reading frame 86 pANT7_cGST 693194 HsxXG013989 16 H02 CENPQ 55166 null centromere protein Q pANT7_cGST 693197 HsxXG013989 17 A03 SHISA5 51246 null shisa family member 5 pANT7_cGST 693200 HsxXG013989 18 B03 TSR3 115939 null TSR3, 20S rRNA accumulation, homolog (S. cerevisiae) pANT7_cGST 693202 HsxXG013989 19 C03 KRTAP9-9 81870 null keratin associated protein 9-9 pANT7_cGST 693203 HsxXG013989 20 D03 TPO 7173 null thyroid peroxidase pANT7_cGST 693204 HsxXG013989 21 E03 RIPK3 11035 null receptor-interacting serine-threonine kinase 3 pANT7_cGST 693207 HsxXG013989 22 F03 FGFR1OP2 26127 null FGFR1 oncogene partner 2 pANT7_cGST 693216 HsxXG013989 23 G03 BRD4 23476 null bromodomain containing 4 pANT7_cGST 693222 HsxXG013989 24 H03 SREK1 140890 null splicing regulatory glutamine/lysine-rich protein 1 pANT7_cGST 695080 HsxXG013989 25 A04 CPEB2 132864 null cytoplasmic polyadenylation element binding protein 2 pANT7_cGST 695083 HsxXG013989 26 B04 ZNF85 7639 null zinc finger protein 85 pANT7_cGST 695102 HsxXG013989 27 C04 SCARA5 286133 null scavenger receptor class A, member 5 (putative) pANT7_cGST 695116 HsxXG013989 28 D04 LONRF1 91694 null LON peptidase N-terminal domain and ring finger 1 pANT7_cGST 695122 HsxXG013989 29 E04 HJURP 55355 null Holliday junction recognition protein pANT7_cGST 695126 HsxXG013989 30 F04 RBM42 79171 null RNA binding motif protein 42 pANT7_cGST 695137 HsxXG013989 31 G04 SLC26A5 375611 null solute carrier family 26 (anion exchanger), member 5 pANT7_cGST 695148 HsxXG013989 32 H04 L3HYPDH 112849 null L-3-hydroxyproline dehydratase (trans-) pANT7_cGST 695152 HsxXG013989 33 A05 ATP6V0D2 245972 null ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2 pANT7_cGST 695154 HsxXG013989 34 B05 AIRE 326 null autoimmune regulator pANT7_cGST 695155 HsxXG013989 35 C05 CYLC2 1539 null cylicin, basic protein of sperm head cytoskeleton 2 pANT7_cGST 695183 HsxXG013989 36 D05 ZC3H14 79882 BC027607 zinc finger CCCH-type containing 14 pANT7_cGST

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695186 HsxXG013989 37 E05 CDC25C 995 BC019089 cell division cycle 25C pANT7_cGST 695194 HsxXG013989 38 F05 C16orf59 80178 EU832694 chromosome 16 open reading frame 59 pANT7_cGST 695197 HsxXG013989 39 G05 SF1 7536 BC020217 splicing factor 1 pANT7_cGST 695212 HsxXG013989 40 H05 CRLF1 9244 BC044634 cytokine receptor-like factor 1 pANT7_cGST 695224 HsxXG013989 41 A06 ALDH3A1 218 null aldehyde dehydrogenase 3 family, member A1 pANT7_cGST 695226 HsxXG013989 42 B06 KLHL33 123103 null kelch-like family member 33 pANT7_cGST 695227 HsxXG013989 43 C06 CDC73 79577 null cell division cycle 73 pANT7_cGST 695234 HsxXG013989 44 D06 C7orf26 79034 null chromosome 7 open reading frame 26 pANT7_cGST 695235 HsxXG013989 45 E06 GPATCH2L 55668 null G patch domain containing 2-like pANT7_cGST 695243 HsxXG013989 46 F06 HEATR1 55127 null HEAT repeat containing 1 pANT7_cGST 695245 HsxXG013989 47 G06 P2RX2 22953 null purinergic receptor P2X, ligand-gated ion channel, 2 pANT7_cGST 695247 HsxXG013989 48 H06 CYLC2 1539 null cylicin, basic protein of sperm head cytoskeleton 2 pANT7_cGST 695248 HsxXG013989 49 A07 ARMCX4 100131755 null armadillo repeat containing, X-linked 4 pANT7_cGST 695253 HsxXG013989 50 B07 CARKD 55739 null carbohydrate kinase domain containing pANT7_cGST 696700 HsxXG013989 51 C07 A1BG 1 null alpha-1-B glycoprotein pANT7_cGST 696704 HsxXG013989 52 D07 NUP214 8021 null nucleoporin 214kDa pANT7_cGST 696711 HsxXG013989 53 E07 GYS1 2997 null glycogen synthase 1 (muscle) pANT7_cGST 696720 HsxXG013989 54 F07 LOC100132705 100132705 null immunoglobulin superfamily member 3-like pANT7_cGST 696721 HsxXG013989 55 G07 MEF2BNB 729991 null MEF2B neighbor pANT7_cGST 696754 HsxXG013989 56 H07 GIGYF2 26058 EU831674 GRB10 interacting GYF protein 2 pANT7_cGST 696831 HsxXG013989 57 A08 E4F1 1877 null E4F transcription factor 1 pANT7_cGST 696832 HsxXG013989 58 B08 BAZ2B 29994 null bromodomain adjacent to zinc finger domain, 2B pANT7_cGST 696843 HsxXG013989 59 C08 D2HGDH 728294 null D-2-hydroxyglutarate dehydrogenase pANT7_cGST 696845 HsxXG013989 60 D08 PON2 5445 null paraoxonase 2 pANT7_cGST 696848 HsxXG013989 61 E08 ZNF658 26149 null zinc finger protein 658 pANT7_cGST 696858 HsxXG013989 62 F08 ULK4 54986 null unc-51 like kinase 4 pANT7_cGST 696870 HsxXG013989 63 G08 PCOLCE2 26577 null procollagen C-endopeptidase enhancer 2 pANT7_cGST 696880 HsxXG013989 64 H08 TTC26 79989 null tetratricopeptide repeat domain 26 pANT7_cGST 696881 HsxXG013989 65 A09 PFKFB1 5207 null 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 pANT7_cGST 696883 HsxXG013989 66 B09 C6orf58 352999 null chromosome 6 open reading frame 58 pANT7_cGST 696884 HsxXG013989 67 C09 COL2A1 1280 null collagen, type II, alpha 1 pANT7_cGST 696886 HsxXG013989 68 D09 RBM33 155435 null RNA binding motif protein 33 pANT7_cGST 696914 HsxXG013989 69 E09 CCDC11 220136 null coiled-coil domain containing 11 pANT7_cGST 696917 HsxXG013989 70 F09 RBMX2 51634 null RNA binding motif protein, X-linked 2 pANT7_cGST 696922 HsxXG013989 71 G09 OR2M2 391194 null olfactory receptor, family 2, subfamily M, member 2 pANT7_cGST 696923 HsxXG013989 72 H09 FAM175B 23172 null family with sequence similarity 175, member B pANT7_cGST 696932 HsxXG013989 73 A10 UBQLN4 56893 null ubiquilin 4 pANT7_cGST 696933 HsxXG013989 74 B10 MXD4 10608 null MAX dimerization protein 4 pANT7_cGST

Camacho-Encina M, et al. Ann Rheum Dis 2019; 0:1699ÿý1705. doi: 10.1136/annrheumdis-2019-215325 Supplementary material Ann Rheum Dis

696935 HsxXG013989 75 C10 FDX1L 112812 null ferredoxin 1-like pANT7_cGST 696936 HsxXG013989 76 D10 POLD4 57804 null polymerase (DNA-directed), delta 4, accessory subunit pANT7_cGST 696938 HsxXG013989 77 E10 FAM19A5 25817 null family with sequence similarity 19 (chemokine (C-C motif)-like)pANT7_cGST 696939 HsxXG013989 78 F10 HEATR5A 25938 null HEAT repeat containing 5A pANT7_cGST 696942 HsxXG013989 79 G10 MFAP3L 9848 null microfibrillar-associated protein 3-like pANT7_cGST 696960 HsxXG013989 80 H10 EHMT2 10919 null euchromatic histone-lysine N-methyltransferase 2 pANT7_cGST 696964 HsxXG013989 81 A11 OXLD1 339229 null oxidoreductase-like domain containing 1 pANT7_cGST 696965 HsxXG013989 82 B11 POLE3 54107 null polymerase (DNA directed), epsilon 3, accessory subunit pANT7_cGST 696970 HsxXG013989 83 C11 NAT8B 51471 null N-acetyltransferase 8B (GCN5-related, putative, gene/pseudopANT7_cGST 696971 HsxXG013989 84 D11 PRPF38B 55119 null pre-mRNA processing factor 38B pANT7_cGST 696979 HsxXG013989 85 E11 ZNF451 26036 null zinc finger protein 451 pANT7_cGST 696981 HsxXG013989 86 F11 PLEKHG5 57449 null pleckstrin homology domain containing, family G (with RhoGpANT7_cGST 696987 HsxXG013989 87 G11 CCDC180 100499483 null coiled-coil domain containing 180 pANT7_cGST 697004 HsxXG013989 88 H11 ACAT1 38 null acetyl-CoA acetyltransferase 1 pANT7_cGST 697069 HsxXG013989 89 A12 PARPBP 55010 null PARP1 binding protein pANT7_cGST 697072 HsxXG013989 90 B12 TRIM51 84767 null tripartite motif-containing 51 pANT7_cGST 697075 HsxXG013989 91 C12 SYNE4 163183 null spectrin repeat containing, nuclear envelope family memberpANT7_cGST 697079 HsxXG013989 92 D12 LOC100506688 100506688 null uncharacterized LOC100506688 pANT7_cGST 701773 HsxXG013989 93 E12 NRAS 4893 BC005219 neuroblastoma RAS viral (v-ras) oncogene homolog pANT7_cGST 701776 HsxXG013989 94 F12 MNDA 4332 BC032319 myeloid cell nuclear differentiation antigen pANT7_cGST 701779 HsxXG013989 95 G12 RELA 5970 BC110830 v-rel avian reticuloendotheliosis viral oncogene homolog A pANT7_cGST HsxXG014242 1 A01 pANT7_cGST 677058 HsxXG014242 2 B01 2900 NUP210 nucleoporin 210kDa pANT7_cGST 677105 HsxXG014242 3 C01 2777 KIAA1324 KIAA1324 pANT7_cGST 677109 HsxXG014242 4 D01 641 SETD3 SET domain containing 3 pANT7_cGST 677224 HsxXG014242 5 E01 680 MRPS35 mitochondrial ribosomal protein S35 pANT7_cGST 677286 HsxXG014242 6 F01 1931 SULF1 sulfatase 1 pANT7_cGST 677345 HsxXG014242 7 G01 671 DDX54 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54 pANT7_cGST 677372 HsxXG014242 8 H01 659 MEPCE methylphosphate capping enzyme pANT7_cGST 677396 HsxXG014242 9 A02 653 PDGFRA platelet-derived growth factor receptor, alpha polypeptide pANT7_cGST 677018 HsxXG014242 10 B02 569 C11orf57 chromosome 11 open reading frame 57 pANT7_cGST 677020 HsxXG014242 11 C02 569 UBTD2 ubiquitin domain containing 2 pANT7_cGST 677043 HsxXG014242 12 D02 2936 SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans) pANT7_cGST 677055 HsxXG014242 13 E02 2906 NID2 nidogen 2 (osteonidogen) pANT7_cGST 677075 HsxXG014242 14 F02 2858 ZNF518A zinc finger protein 518A pANT7_cGST 677076 HsxXG014242 15 G02 2858 CKAP5 cytoskeleton associated protein 5 pANT7_cGST 677102 HsxXG014242 16 H02 2786 DGKZ diacylglycerol kinase, zeta pANT7_cGST 677106 HsxXG014242 17 A03 2771 SETD5 SET domain containing 5 pANT7_cGST

Camacho-Encina M, et al. Ann Rheum Dis 2019; 0:1699ÿý1705. doi: 10.1136/annrheumdis-2019-215325 Supplementary material Ann Rheum Dis

677112 HsxXG014242 18 B03 641 HDHD1 haloacid dehalogenase-like hydrolase domain containing 1 pANT7_cGST 677216 HsxXG014242 19 C03 683 EXOG endo/exonuclease (5'-3'), endonuclease G-like pANT7_cGST 677221 HsxXG014242 20 D03 683 IDI1 isopentenyl-diphosphate delta isomerase 1 pANT7_cGST 677226 HsxXG014242 21 E03 680 SULT1C4 sulfotransferase family, cytosolic, 1C, member 4 pANT7_cGST 677233 HsxXG014242 22 F03 677 TEFM transcription elongation factor, mitochondrial pANT7_cGST 677243 HsxXG014242 23 G03 674 CCDC158 coiled-coil domain containing 158 pANT7_cGST 677258 HsxXG014242 24 H03 1967 MAP3K13 mitogen-activated protein kinase kinase kinase 13 pANT7_cGST 677274 HsxXG014242 25 A04 1952 CDHR5 cadherin-related family member 5 pANT7_cGST 677285 HsxXG014242 26 B04 1931 NRP1 neuropilin 1 pANT7_cGST 677299 HsxXG014242 27 C04 1919 RNF214 ring finger protein 214 pANT7_cGST 677300 HsxXG014242 28 D04 1919 AP1G2 adaptor-related protein complex 1, gamma 2 subunit pANT7_cGST 677307 HsxXG014242 29 E04 1913 SCNN1D sodium channel, non-voltage-gated 1, delta subunit pANT7_cGST 677310 HsxXG014242 30 F04 1910 PHTF1 putative homeodomain transcription factor 1 pANT7_cGST 677312 HsxXG014242 31 G04 1910 COL20A1 collagen, type XX, alpha 1 pANT7_cGST 677326 HsxXG014242 32 H04 1895 ITGA9 integrin, alpha 9 pANT7_cGST 677329 HsxXG014242 33 A05 1892 IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells,pANT7_cGST 677334 HsxXG014242 34 B05 1889 CDH7 cadherin 7, type 2 pANT7_cGST 677351 HsxXG014242 35 C05 668 TMEM26 transmembrane protein 26 pANT7_cGST 677352 HsxXG014242 36 D05 668 AP5B1 adaptor-related protein complex 5, beta 1 subunit pANT7_cGST 677353 HsxXG014242 37 E05 668 C17orf59 chromosome 17 open reading frame 59 pANT7_cGST 677354 HsxXG014242 38 F05 668 RAB37 RAB37, member RAS oncogene family pANT7_cGST 677355 HsxXG014242 39 G05 668 RHBDD2 rhomboid domain containing 2 pANT7_cGST 677361 HsxXG014242 40 H05 668 PLBD1 phospholipase B domain containing 1 pANT7_cGST 677362 HsxXG014242 41 A06 665 CADPS Ca++-dependent secretion activator pANT7_cGST 677364 HsxXG014242 42 B06 665 THNSL1 threonine synthase-like 1 (S. cerevisiae) pANT7_cGST 677368 HsxXG014242 43 C06 662 LSM14B LSM14B, SCD6 homolog B (S. cerevisiae) pANT7_cGST 677369 HsxXG014242 44 D06 662 TSPY8 testis specific protein, Y-linked 8 pANT7_cGST 677382 HsxXG014242 45 E06 656 COG8 component of oligomeric golgi complex 8 pANT7_cGST 677392 HsxXG014242 46 F06 653 SDS serine dehydratase pANT7_cGST 677393 HsxXG014242 47 G06 653 MAU2 MAU2 chromatid cohesion factor homolog (C. elegans) pANT7_cGST 677399 HsxXG014242 48 H06 650 HOXD12 homeobox D12 pANT7_cGST 677401 HsxXG014242 49 A07 650 GH1 growth hormone 1 pANT7_cGST 701783 HsxXG014242 50 B07 2027 CD22 933 BC109306 Homo sapiens CD22 molecule pANT7_cGST 701789 HsxXG014242 51 C07 773 NROB2 8431 NM_021969 nuclear receptor subfamily 0, group B, member 2 pANT7_cGST 701794 HsxXG014242 52 D07 1736 BC044640 phosphatidylinositol glycan anchor biosynthesis, class Z pANT7_cGST 701796 HsxXG014242 53 E07 1733 BC001371 ER degradation enhancer, mannosidase alpha-like 2 pANT7_cGST 676797 HsxXG014242 54 F07 848 ELMOD1 ELMO/CED-12 domain containing 1 pANT7_cGST 676799 HsxXG014242 55 G07 848 STEAP4 STEAP family member 4 pANT7_cGST

Camacho-Encina M, et al. Ann Rheum Dis 2019; 0:1699ÿý1705. doi: 10.1136/annrheumdis-2019-215325 Supplementary material Ann Rheum Dis

676802 HsxXG014242 56 H07 845 ZDHHC19 zinc finger, DHHC-type containing 19 pANT7_cGST 676803 HsxXG014242 57 A08 845 PLEKHS1 pleckstrin homology domain containing, family S member 1pANT7_cGST 676813 HsxXG014242 58 B08 842 PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta pANT7_cGST 676815 HsxXG014242 59 C08 842 ZNF783 zinc finger family member 783 pANT7_cGST 676819 HsxXG014242 60 D08 839 GFOD2 glucose-fructose oxidoreductase domain containing 2 pANT7_cGST 676821 HsxXG014242 61 E08 839 PPP1R7 protein phosphatase 1, regulatory subunit 7 pANT7_cGST 676823 HsxXG014242 62 F08 839 UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 pANT7_cGST 713216 HsxXG014242 63 G08 1448 GSK3A BC027984 glycogen synthase kinase 3 alpha pANT7_cGST 713218 HsxXG014242 64 H08 533 TMEM65 BC032396 transmembrane protein 65 pANT7_cGST 713219 HsxXG014242 65 A09 1952 TDRD3 BC030514 tudor domain containing 3 pANT7_cGST 713220 HsxXG014242 66 B09 653 CLDN5 BC032363 claudin 5 pANT7_cGST 713221 HsxXG014242 67 C09 425 CHCHD4 BC033775 coiled-coil-helix-coiled-coil-helix domain containing 4 pANT7_cGST 713224 HsxXG014242 68 D09 347 VAMP2 BC033870 vesicle-associated membrane protein 2 (synaptobrevin 2) pANT7_cGST 713226 HsxXG014242 69 E09 575 RNF185 BC035684 ring finger protein 185 pANT7_cGST 713227 HsxXG014242 70 F09 545 CMTM3 BC036042 CKLF-like MARVEL transmembrane domain containing 3 pANT7_cGST 713228 HsxXG014242 71 G09 1469 ZNF512 BC043221 zinc finger protein 512 pANT7_cGST 713229 HsxXG014242 72 H09 1406 ETS2 BC042954 v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)pANT7_cGST 713232 HsxXG014242 73 A10 1628 TTLL7 BC048970 tubulin tyrosine ligase-like family, member 7 pANT7_cGST 713233 HsxXG014242 74 B10 1397 SCARA3 BC060811 scavenger receptor class A, member 3 pANT7_cGST 713235 HsxXG014242 75 C10 644 HMGB1 BC003378 high mobility group box 1 pANT7_cGST 713237 HsxXG014242 76 D10 386 C7orf49 BC000168 chromosome 7 open reading frame 49 pANT7_cGST 713238 HsxXG014242 77 E10 614 ADPRM BC001294 ADP-ribose/CDP-alcohol diphosphatase, manganese-dependentpANT7_cGST 713239 HsxXG014242 78 F10 659 CREG1 BC006786 cellular repressor of E1A-stimulated genes 1 pANT7_cGST 713240 HsxXG014242 79 G10 521 FAM156A BC000867 family with sequence similarity 156, member A pANT7_cGST 713243 HsxXG014242 80 H10 728 ECI1 BC009631 enoyl-CoA delta isomerase 1 pANT7_cGST 713244 HsxXG014242 81 A11 1154 ARMC8 BC013424 armadillo repeat containing 8 pANT7_cGST 713245 HsxXG014242 82 B11 758 TMCO6 BC009618 transmembrane and coiled-coil domains 6 pANT7_cGST 713246 HsxXG014242 83 C11 821 UBR7 BC015046 ubiquitin protein ligase E3 component n-recognin 7 (putative)pANT7_cGST 713247 HsxXG014242 84 D11 878 RPS2 BC016178 ribosomal protein S2 pANT7_cGST 713249 HsxXG014242 85 E11 752 C11orf68 BC010512 chromosome 11 open reading frame 68 pANT7_cGST 713250 HsxXG014242 86 F11 437 CST3 BC013083 cystatin C pANT7_cGST 713251 HsxXG014242 87 G11 725 HTATIP2 BC015358 HIV-1 Tat interactive protein 2, 30kDa pANT7_cGST 713252 HsxXG014242 88 H11 1133 FIP1L1 BC017724 FIP1 like 1 (S. cerevisiae) pANT7_cGST 713254 HsxXG014242 89 A12 752 RAB34 BC016841 RAB34, member RAS oncogene family pANT7_cGST 713256 HsxXG014242 90 B12 1043 ACTR3B BC015207 ARP3 actin-related protein 3 homolog B (yeast) pANT7_cGST 713257 HsxXG014242 91 C12 713 EFNA3 BC017722 ephrin-A3 pANT7_cGST 713259 HsxXG014242 92 D12 893 FAM105B BC015392 family with sequence similarity 105, member B pANT7_cGST 713261 HsxXG014242 93 E12 1187 DENND1B BC022561 DENN/MADD domain containing 1B pANT7_cGST

Camacho-Encina M, et al. Ann Rheum Dis 2019; 0:1699ÿý1705. doi: 10.1136/annrheumdis-2019-215325 Supplementary material Ann Rheum Dis

713264 HsxXG014242 94 F12 686 HS2ST1 BC025990 heparan sulfate 2-O-sulfotransferase 1 pANT7_cGST 713269 HsxXG014242 95 G12 785 EMC10 BC032948 ER membrane protein complex subunit 10 pANT7_cGST HsxXG014242 96 H12 pANT7_cGST HsxXG014243 1 A01 pANT7_cGST 713274 HsxXG014243 2 B01 935 SLC1A6 BC028721 solute carrier family 1 (high affinity aspartate/glutamate tranpANT7_cGST 713279 HsxXG014243 3 C01 338 FAM27E3 BC032035 family with sequence similarity 27, member E3 pANT7_cGST 713281 HsxXG014243 4 D01 167 RPS29 BC035313 ribosomal protein S29 pANT7_cGST 713282 HsxXG014243 5 E01 884 AEBP2 BC022220 AE binding protein 2 pANT7_cGST 713283 HsxXG014243 6 F01 356 RPS20 BC087850 ribosomal protein S20 pANT7_cGST 713284 HsxXG014243 7 G01 248 TIMM8B BC105986 translocase of inner mitochondrial membrane 8 homolog B (pANT7_cGST 713286 HsxXG014243 8 H01 626 HMGB2 BC100019 high mobility group box 2 pANT7_cGST 713287 HsxXG014243 9 A02 227 NDUFC1 BC107682 NADH dehydrogenase (ubiquinone) 1, subcomplex unknown,pANT7_cGST 713293 HsxXG014243 10 B02 818 ZNF80 BC069606 zinc finger protein 80 pANT7_cGST 713294 HsxXG014243 11 C02 341 XCL2 BC069360 chemokine (C motif) ligand 2 pANT7_cGST 713295 HsxXG014243 12 D02 281 DEFA1 BC069423 defensin, alpha 1 pANT7_cGST 713301 HsxXG014243 13 E02 260 SEPW1 BC047893 selenoprotein W, 1 pANT7_cGST 713306 HsxXG014243 14 F02 266 CCL18 BC069700 chemokine (C-C motif) ligand 18 (pulmonary and activation-rpANT7_cGST 713311 HsxXG014243 15 G02 770 PSMD8 BC065006 proteasome (prosome, macropain) 26S subunit, non-ATPase,pANT7_cGST 713312 HsxXG014243 16 H02 524 PPAPDC1B BC106014 phosphatidic acid phosphatase type 2 domain containing 1BpANT7_cGST 713313 HsxXG014243 17 A03 1175 TMEM201 BC121187 transmembrane protein 201 pANT7_cGST 713314 HsxXG014243 18 B03 488 C19orf66 BC010847 chromosome 19 open reading frame 66 pANT7_cGST 713316 HsxXG014243 19 C03 1082 UBR7 BC017013 ubiquitin protein ligase E3 component n-recognin 7 (putative)pANT7_cGST 713317 HsxXG014243 20 D03 557 SPATC1L BC065570 spermatogenesis and centriole associated 1-like pANT7_cGST 713318 HsxXG014243 21 E03 1079 SEC14L4 BC139912 SEC14-like 4 (S. cerevisiae) pANT7_cGST 713319 HsxXG014243 22 F03 359 TMEM230 BC110408 transmembrane protein 230 pANT7_cGST 713323 HsxXG014243 23 G03 551 GPIHBP1 BC035810 glycosylphosphatidylinositol anchored high density lipoproteipANT7_cGST 713329 HsxXG014243 24 H03 383 RPL22 BC066314 ribosomal protein L22 pANT7_cGST 713330 HsxXG014243 25 A04 638 AMN1 BC067906 antagonist of mitotic exit network 1 homolog (S. cerevisiae)pANT7_cGST 713332 HsxXG014243 26 B04 662 SRSF2 BC070086 serine/arginine-rich splicing factor 2 pANT7_cGST 713335 HsxXG014243 27 C04 434 SELM BC068004 selenoprotein M pANT7_cGST 713337 HsxXG014243 28 D04 602 SRSF1 BC033785 serine/arginine-rich splicing factor 1 pANT7_cGST 713338 HsxXG014243 29 E04 959 HNRNPA1 BC074502 heterogeneous nuclear ribonucleoprotein A1 pANT7_cGST 713341 HsxXG014243 30 F04 1091 OAS1 BC061587 2'-5'-oligoadenylate synthetase 1, 40/46kDa pANT7_cGST 713345 HsxXG014243 31 G04 407 SRP14 BC071716 signal recognition particle 14kDa (homologous Alu RNA bindipANT7_cGST 713347 HsxXG014243 32 H04 584 SELT BC071699 selenoprotein T pANT7_cGST 713349 HsxXG014243 33 A05 455 IL3 BC066273 interleukin 3 (colony-stimulating factor, multiple) pANT7_cGST 713351 HsxXG014243 34 B05 1112 SMYD2 BC049367 SET and MYND domain containing 2 pANT7_cGST 713352 HsxXG014243 35 C05 470 RFESD BC048979 Rieske (Fe-S) domain containing pANT7_cGST

Camacho-Encina M, et al. Ann Rheum Dis 2019; 0:1699ÿý1705. doi: 10.1136/annrheumdis-2019-215325 Supplementary material Ann Rheum Dis

713353 HsxXG014243 36 D05 1097 PKM BC094767 pyruvate kinase, muscle pANT7_cGST 713355 HsxXG014243 37 E05 1271 MIPOL1 BC036124 mirror-image polydactyly 1 pANT7_cGST 713357 HsxXG014243 38 F05 719 SNRPN BC024777 small nuclear ribonucleoprotein polypeptide N pANT7_cGST 713359 HsxXG014243 39 G05 944 RAB3IP BC059358 RAB3A interacting protein pANT7_cGST 713360 HsxXG014243 40 H05 794 CLEC17A BC144665 C-type lectin domain family 17, member A pANT7_cGST 713361 HsxXG014243 41 A06 347 LRRD1 BC144674 leucine-rich repeats and death domain containing 1 pANT7_cGST 713362 HsxXG014243 42 B06 236 SMR3B BC144529 submaxillary gland androgen regulated protein 3B pANT7_cGST 713364 HsxXG014243 43 C06 566 CT45A5 BC144527 cancer/testis antigen family 45, member A5 pANT7_cGST 713366 HsxXG014243 44 D06 566 CT45A5 BC144528 cancer/testis antigen family 45, member A5 pANT7_cGST 713367 HsxXG014243 45 E06 893 C2orf54 BC125154 chromosome 2 open reading frame 54 pANT7_cGST 713369 HsxXG014243 46 F06 1109 MIER1 BC125217 mesoderm induction early response 1, transcriptional regulatpANT7_cGST 713371 HsxXG014243 47 G06 1109 MIER1 BC125218 mesoderm induction early response 1, transcriptional regulatpANT7_cGST 713373 HsxXG014243 48 H06 275 LCE3D BC120935 late cornified envelope 3D pANT7_cGST 713377 HsxXG014243 49 A07 371 TAF13 BC121181 TAF13 RNA polymerase II, TATA box binding protein (TBP)-asspANT7_cGST 713378 HsxXG014243 50 B07 350 GAGE12F BC121182 G antigen 12F pANT7_cGST 713379 HsxXG014243 51 C07 671 PLSCR2 BC120969 phospholipid scramblase 2 pANT7_cGST 713380 HsxXG014243 52 D07 350 GAGE12F BC121183 G antigen 12F pANT7_cGST 713381 HsxXG014243 53 E07 650 HOXD12 BC121104 homeobox D12 pANT7_cGST 713382 HsxXG014243 54 F07 257 SNRPF BC128452 small nuclear ribonucleoprotein polypeptide F pANT7_cGST 713387 HsxXG014243 55 G07 530 TMEM190 BC128190 transmembrane protein 190 pANT7_cGST 713389 HsxXG014243 56 H07 995 C4orf29 BC128143 chromosome 4 open reading frame 29 pANT7_cGST 713392 HsxXG014243 57 A08 671 LRP5L BC139736 low density lipoprotein receptor-related protein 5-like pANT7_cGST 713394 HsxXG014243 58 B08 1769 TMEM132B BC131621 transmembrane protein 132B pANT7_cGST 713396 HsxXG014243 59 C08 374 RUSC1-AS1 BC131614 RUSC1 antisense RNA 1 pANT7_cGST 713399 HsxXG014243 60 D08 1163 PDHA2 BC127637 pyruvate dehydrogenase (lipoamide) alpha 2 pANT7_cGST 713401 HsxXG014243 61 E08 671 CHIC1 BC127728 cysteine-rich hydrophobic domain 1 pANT7_cGST 713407 HsxXG014243 62 F08 911 KIR2DS4 BC171788 killer cell immunoglobulin-like receptor, two domains, shortpANT7_cGST c 713414 HsxXG014243 63 G08 416 CCDC169 BC171882 coiled-coil domain containing 169 pANT7_cGST 713416 HsxXG014243 64 H08 266 FAM25A BC171878 family with sequence similarity 25, member A pANT7_cGST 713417 HsxXG014243 65 A09 416 CCDC169 BC171880 coiled-coil domain containing 169 pANT7_cGST 713419 HsxXG014243 66 B09 266 FAM25C BC171871 family with sequence similarity 25, member C pANT7_cGST 713422 HsxXG014243 67 C09 266 FAM25C BC146972 family with sequence similarity 25, member C pANT7_cGST 713423 HsxXG014243 68 D09 284 DEFB132 BC137292 defensin, beta 132 pANT7_cGST 713426 HsxXG014243 69 E09 257 SPINK9 BC137531 serine peptidase inhibitor, Kazal type 9 pANT7_cGST 713429 HsxXG014243 70 F09 1376 XKR3 BC137522 XK, Kell blood group complex subunit-related family, memberpANT7_cGST 713430 HsxXG014243 71 G09 1400 ZMAT1 BC140920 zinc finger, matrin-type 1 pANT7_cGST 713432 HsxXG014243 72 H09 266 FAM25BP BC146968 family with sequence similarity 25, member B pANT7_cGST 713435 HsxXG014243 73 A10 455 BOLA2B BC137534 bolA family member 2B pANT7_cGST

Camacho-Encina M, et al. Ann Rheum Dis 2019; 0:1699ÿý1705. doi: 10.1136/annrheumdis-2019-215325 Supplementary material Ann Rheum Dis

713436 HsxXG014243 74 B10 446 FAM72A BC146992 family with sequence similarity 72, member A pANT7_cGST 713437 HsxXG014243 75 C10 266 FAM25C BC146991 family with sequence similarity 25, member C pANT7_cGST 713440 HsxXG014243 76 D10 266 FAM25C BC146955 family with sequence similarity 25, member C pANT7_cGST 713444 HsxXG014243 77 E10 374 NPB BC146890 neuropeptide B pANT7_cGST 713449 HsxXG014243 78 F10 902 GPR108 BC150657 G protein-coupled receptor 108 pANT7_cGST 713453 HsxXG014243 79 G10 413 03-Mar BC146964 membrane-associated ring finger (C3HC4) 3, E3 ubiquitin propANT7_cGST 713456 HsxXG014243 80 H10 266 FAM25C BC147022 family with sequence similarity 25, member C pANT7_cGST 713457 HsxXG014243 81 A11 986 GATSL2 BC147030 GATS protein-like 2 pANT7_cGST 713459 HsxXG014243 82 B11 266 FAM25C BC147026 family with sequence similarity 25, member C pANT7_cGST 713463 HsxXG014243 83 C11 350 GAGE12F BC144193 G antigen 12F pANT7_cGST 713464 HsxXG014243 84 D11 389 TEX38 BC144027 testis expressed 38 pANT7_cGST 713467 HsxXG014243 85 E11 677 HYKK BC144383 hydroxylysine kinase pANT7_cGST 713469 HsxXG014243 86 F11 377 HIST1H2BH BC096118 histone cluster 1, H2bh pANT7_cGST 713470 HsxXG014243 87 G11 1916 KRT2 BC096294 keratin 2 pANT7_cGST 713471 HsxXG014243 88 H11 461 CDX1 BC096252 caudal type homeobox 1 pANT7_cGST 713472 HsxXG014243 89 A12 929 SOAT2 BC099626 sterol O-acyltransferase 2 pANT7_cGST 713479 HsxXG014243 90 B12 2132 ALOXE3 BC101938 arachidonate lipoxygenase 3 pANT7_cGST 713480 HsxXG014243 91 C12 488 NKAIN1 BC098249 Na+/K+ transporting ATPase interacting 1 pANT7_cGST 713483 HsxXG014243 92 D12 554 APOA1BP BC100932 apolipoprotein A-I binding protein pANT7_cGST 713484 HsxXG014243 93 E12 500 KRTAP1-3 BC101151 keratin associated protein 1-3 pANT7_cGST 713485 HsxXG014243 94 F12 842 PTCRA BC100771 pre T-cell antigen receptor alpha pANT7_cGST 713492 HsxXG014243 95 G12 263 COX6B2 BC100899 cytochrome c oxidase subunit VIb polypeptide 2 (testis) pANT7_cGST HsxXG014243 96 H12 pANT7_cGST HsxXG014244 1 A01 pANT7_cGST 713493 HsxXG014244 2 B01 263 COX6B2 BC100900 cytochrome c oxidase subunit VIb polypeptide 2 (testis) pANT7_cGST 713494 HsxXG014244 3 C01 383 KRTAP2-4 BC101147 keratin associated protein 2-4 pANT7_cGST 713495 HsxXG014244 4 D01 188 KRTAP19-7 BC103837 keratin associated protein 19-7 pANT7_cGST 713496 HsxXG014244 5 E01 194 DEFB106B BC100845 defensin, beta 106B pANT7_cGST 713501 HsxXG014244 6 F01 2741 SAFB BC143938 scaffold attachment factor B pANT7_cGST 713504 HsxXG014244 7 G01 2588 AAK1 BC143710 AP2 associated kinase 1 pANT7_cGST 713506 HsxXG014244 8 H01 344 TMEM218 BC144270 transmembrane protein 218 pANT7_cGST 713507 HsxXG014244 9 A02 1250 SERINC5 BC101281 serine incorporator 5 pANT7_cGST 713509 HsxXG014244 10 B02 1310 PNPLA1 BC103907 patatin-like phospholipase domain containing 1 pANT7_cGST 713512 HsxXG014244 11 C02 1334 PLD5 BC101374 phospholipase D family, member 5 pANT7_cGST 713513 HsxXG014244 12 D02 1763 CWF19L2 BC110439 CWF19-like 2, cell cycle control (S. pombe) pANT7_cGST 713516 HsxXG014244 13 E02 1808 CWF19L2 BC110440 CWF19-like 2, cell cycle control (S. pombe) pANT7_cGST 713517 HsxXG014244 14 F02 503 RASSF3 BC100952 Ras association (RalGDS/AF-6) domain family member 3 pANT7_cGST 713519 HsxXG014244 15 G02 494 NRN1L BC100864 neuritin 1-like pANT7_cGST

Camacho-Encina M, et al. Ann Rheum Dis 2019; 0:1699ÿý1705. doi: 10.1136/annrheumdis-2019-215325 Supplementary material Ann Rheum Dis

713520 HsxXG014244 16 H02 785 FBXW12 BC101303 F-box and WD repeat domain containing 12 pANT7_cGST 713522 HsxXG014244 17 A03 1295 ZIK1 BC103959 zinc finger protein interacting with K protein 1 pANT7_cGST 713524 HsxXG014244 18 B03 1766 CPEB2 BC103940 cytoplasmic polyadenylation element binding protein 2 pANT7_cGST 713526 HsxXG014244 19 C03 1196 ANKDD1A BC101273 ankyrin repeat and death domain containing 1A pANT7_cGST 713527 HsxXG014244 20 D03 1268 ANKDD1A BC101275 ankyrin repeat and death domain containing 1A pANT7_cGST 713528 HsxXG014244 21 E03 1643 ARHGAP27 BC101388 Rho GTPase activating protein 27 pANT7_cGST 713529 HsxXG014244 22 F03 2216 ZNF624 BC103944 zinc finger protein 624 pANT7_cGST 713531 HsxXG014244 23 G03 1643 ARHGAP27 BC101389 Rho GTPase activating protein 27 pANT7_cGST 713532 HsxXG014244 24 H03 248 COX7A2 BC100852 cytochrome c oxidase subunit VIIa polypeptide 2 (liver) pANT7_cGST 713533 HsxXG014244 25 A04 413 NANOS2 BC117484 nanos homolog 2 (Drosophila) pANT7_cGST 713536 HsxXG014244 26 B04 1616 SLC17A8 BC117229 solute carrier family 17 (vesicular glutamate transporter), mempANT7_cGST 713538 HsxXG014244 27 C04 1052 RRM2B BC117496 ribonucleotide reductase M2 B (TP53 inducible) pANT7_cGST 713540 HsxXG014244 28 D04 1868 FOXP2 BC126104 forkhead box P2 pANT7_cGST 713541 HsxXG014244 29 E04 1211 TTLL10 BC126152 tubulin tyrosine ligase-like family, member 10 pANT7_cGST 713543 HsxXG014244 30 F04 584 KRTAP4-11 BC126131 keratin associated protein 4-11 pANT7_cGST 713544 HsxXG014244 31 G04 1943 C1orf127 BC126349 chromosome 1 open reading frame 127 pANT7_cGST 713546 HsxXG014244 32 H04 890 CCDC102B BC126450 coiled-coil domain containing 102B pANT7_cGST 713547 HsxXG014244 33 A05 620 AANAT BC126332 aralkylamine N-acetyltransferase pANT7_cGST 713552 HsxXG014244 34 B05 242 NEDD8 BC104201 neural precursor cell expressed, developmentally down-regulpANT7_cGST 713553 HsxXG014244 35 C05 1382 BTBD3 BC109315 BTB (POZ) domain containing 3 pANT7_cGST 713554 HsxXG014244 36 D05 275 CCL4 BC104226 chemokine (C-C motif) ligand 4 pANT7_cGST 713557 HsxXG014244 37 E05 1034 FAM117B BC106906 family with sequence similarity 117, member B pANT7_cGST 713558 HsxXG014244 38 F05 1199 ZNF514 BC110525 zinc finger protein 514 pANT7_cGST 713559 HsxXG014244 39 G05 746 DIO1 BC107170 deiodinase, iodothyronine, type I pANT7_cGST 713561 HsxXG014244 40 H05 683 EXOG BC104212 endo/exonuclease (5'-3'), endonuclease G-like pANT7_cGST 713563 HsxXG014244 41 A06 1160 GALR2 BC109052 galanin receptor 2 pANT7_cGST 713564 HsxXG014244 42 B06 1319 GABRP BC109106 gamma-aminobutyric acid (GABA) A receptor, pi pANT7_cGST 713569 HsxXG014244 43 C06 506 SUDS3 BC093990 suppressor of defective silencing 3 homolog (S. cerevisiae) pANT7_cGST 713570 HsxXG014244 44 D06 530 TNFSF18 BC093986 tumor necrosis factor (ligand) superfamily, member 18 pANT7_cGST 705688 HsxXG014244 45 E06 344 TMEM218 BC144277 transmembrane protein 218 pANT7_cGST 705689 HsxXG014244 46 F06 911 KIR2DS4 BC144566 killer cell immunoglobulin-like receptor, two domains, shortpANT7_cGST c 705690 HsxXG014244 47 G06 959 FRMPD2 BC144636 FERM and PDZ domain containing 2 pANT7_cGST 705691 HsxXG014244 48 H06 959 FRMPD2 BC144639 FERM and PDZ domain containing 2 pANT7_cGST 705692 HsxXG014244 49 A07 1553 LRRTM4 BC110058 leucine rich repeat transmembrane neuronal 4 pANT7_cGST 705694 HsxXG014244 50 B07 1748 SPIRE1 BC125207 spire-type actin nucleation factor 1 pANT7_cGST 705695 HsxXG014244 51 C07 257 SNRPF BC063397 small nuclear ribonucleoprotein polypeptide F pANT7_cGST 705696 HsxXG014244 52 D07 1628 TTLL7 BC048970 tubulin tyrosine ligase-like family, member 7 pANT7_cGST 705697 HsxXG014244 53 E07 3071 ITGA10 BC144637 integrin, alpha 10 pANT7_cGST

Camacho-Encina M, et al. Ann Rheum Dis 2019; 0:1699ÿý1705. doi: 10.1136/annrheumdis-2019-215325 Supplementary material Ann Rheum Dis

705698 HsxXG014244 54 F07 2510 TBC1D2B BC144482 TBC1 domain family, member 2B pANT7_cGST 705702 HsxXG014244 55 G07 2429 PCDHGB1 BC103926 protocadherin gamma subfamily B, 1 pANT7_cGST 705705 HsxXG014244 56 H07 2402 CDH20 BC101048 cadherin 20, type 2 pANT7_cGST 705707 HsxXG014244 57 A08 2375 ZNF541 BC101050 zinc finger protein 541 pANT7_cGST 705708 HsxXG014244 58 B08 2375 ZNF541 BC101051 zinc finger protein 541 pANT7_cGST 705709 HsxXG014244 59 C08 2375 ZNF541 BC101051 zinc finger protein 541 pANT7_cGST 705710 HsxXG014244 60 D08 2375 ZNF541 BC101053 zinc finger protein 541 pANT7_cGST 705712 HsxXG014244 61 E08 3407 CENPJ BC113111 centromere protein J pANT7_cGST 705725 HsxXG014244 62 F08 1280 GLDN BC113397 gliomedin pANT7_cGST 705729 HsxXG014244 63 G08 2093 WDR65 BC117306 WD repeat domain 65 pANT7_cGST 705730 HsxXG014244 64 H08 1319 NFIX BC117115 nuclear factor I/X (CCAAT-binding transcription factor) pANT7_cGST 705733 HsxXG014244 65 A09 1094 GABRE BC047108 gamma-aminobutyric acid (GABA) A receptor, epsilon pANT7_cGST 705735 HsxXG014244 66 B09 1121 FANCF BC047028 Fanconi anemia, complementation group F pANT7_cGST 705738 HsxXG014244 67 C09 881 PKDCC BC094697 protein kinase domain containing, cytoplasmic pANT7_cGST 705739 HsxXG014244 68 D09 959 HNRNPA1L2 BC108266 heterogeneous nuclear ribonucleoprotein A1-like 2 pANT7_cGST 705740 HsxXG014244 69 E09 776 RAB34 BC091510 RAB34, member RAS oncogene family pANT7_cGST 705745 HsxXG014244 70 F09 1655 AP5B1 BC126905 adaptor-related protein complex 5, beta 1 subunit pANT7_cGST 705746 HsxXG014244 71 G09 557 VCX3A BC126902 variable charge, X-linked 3A pANT7_cGST 705749 HsxXG014244 72 H09 416 VCX2 BC134350 variable charge, X-linked 2 pANT7_cGST 705750 HsxXG014244 73 A10 344 H2AFB2 BC134365 H2A histone family, member B2 pANT7_cGST 705751 HsxXG014244 74 B10 476 C9orf135 BC150564 chromosome 9 open reading frame 135 pANT7_cGST 705754 HsxXG014244 75 C10 926 ASB12 BC104946 ankyrin repeat and SOCS box containing 12 pANT7_cGST 705755 HsxXG014244 76 D10 971 TMEM165 BC104980 transmembrane protein 165 pANT7_cGST 705756 HsxXG014244 77 E10 971 TMEM165 BC104978 transmembrane protein 165 pANT7_cGST 705758 HsxXG014244 78 F10 1040 C15orf27 BC104955 chromosome 15 open reading frame 27 pANT7_cGST 705759 HsxXG014244 79 G10 377 NPPC BC105065 natriuretic peptide C pANT7_cGST 705761 HsxXG014244 80 H10 236 KRTAP21-1 BC105029 keratin associated protein 21-1 pANT7_cGST 705763 HsxXG014244 81 A11 935 MAMSTR BC105056 MEF2 activating motif and SAP domain containing transcriptipANT7_cGST 705765 HsxXG014244 82 B11 662 HIST1H1D BC111971 histone cluster 1, H1d pANT7_cGST 705766 HsxXG014244 83 C11 929 AK9 BC111948 adenylate kinase 9 pANT7_cGST 705769 HsxXG014244 84 D11 1235 PTPRR BC122866 protein tyrosine phosphatase, receptor type, R pANT7_cGST 705772 HsxXG014244 85 E11 593 CXXC4 BC119752 CXXC finger protein 4 pANT7_cGST 705773 HsxXG014244 86 F11 491 ZNF321P BC119627 zinc finger protein 321, pseudogene pANT7_cGST 705775 HsxXG014244 87 G11 1553 ANKRD13D BC121024 ankyrin repeat domain 13 family, member D pANT7_cGST 705776 HsxXG014244 88 H11 926 CDYL BC119682 chromodomain protein, Y-like pANT7_cGST 705778 HsxXG014244 89 A12 1565 TTC39C BC121035 tetratricopeptide repeat domain 39C pANT7_cGST 705780 HsxXG014244 90 B12 959 HNRNPA1 BC121133 heterogeneous nuclear ribonucleoprotein A1 pANT7_cGST 705781 HsxXG014244 91 C12 476 SNRPC BC121082 small nuclear ribonucleoprotein polypeptide C pANT7_cGST

Camacho-Encina M, et al. Ann Rheum Dis 2019; 0:1699ÿý1705. doi: 10.1136/annrheumdis-2019-215325 Supplementary material Ann Rheum Dis

705782 HsxXG014244 92 D12 908 FBXL17 BC126144 F-box and leucine-rich repeat protein 17 pANT7_cGST 705784 HsxXG014244 93 E12 497 C2orf73 BC126246 chromosome 2 open reading frame 73 pANT7_cGST 705785 HsxXG014244 94 F12 1301 WNK1 BC130467 WNK lysine deficient protein kinase 1 pANT7_cGST 705787 HsxXG014244 95 G12 1730 HECTD3 BC130470 HECT domain containing E3 ubiquitin protein ligase 3 pANT7_cGST HsxXG014244 96 H12 pANT7_cGST HsxXG014245 1 A01 pANT7_cGST 705790 HsxXG014245 2 B01 374 BLOC1S1 BC130640 biogenesis of lysosomal organelles complex-1, subunit 1 pANT7_cGST 705791 HsxXG014245 3 C01 371 BOLA2 BC130401 bolA family member 2 pANT7_cGST 705793 HsxXG014245 4 D01 371 BOLA2 BC130403 bolA family member 2 pANT7_cGST 705796 HsxXG014245 5 E01 2039 COL10A1 BC130623 collagen, type X, alpha 1 pANT7_cGST 705798 HsxXG014245 6 F01 539 CTAG1A BC130364 cancer/testis antigen 1A pANT7_cGST 705799 HsxXG014245 7 G01 1052 RRM2B BC130628 ribonucleotide reductase M2 B (TP53 inducible) pANT7_cGST 705801 HsxXG014245 8 H01 311 PF4V1 BC130657 platelet factor 4 variant 1 pANT7_cGST 705806 HsxXG014245 9 A02 1637 PRPF38B BC132963 pre-mRNA processing factor 38B pANT7_cGST 705807 HsxXG014245 10 B02 1865 C17orf104 BC132822 chromosome 17 open reading frame 104 pANT7_cGST 705808 HsxXG014245 11 C02 710 SLC25A29 BC132966 solute carrier family 25 (mitochondrial carnitine/acylcarnitinepANT7_cGST 705809 HsxXG014245 12 D02 494 PLA2G10 BC106731 phospholipase A2, group X pANT7_cGST 705811 HsxXG014245 13 E02 452 RIPPLY1 BC105692 ripply transcriptional repressor 1 pANT7_cGST 705812 HsxXG014245 14 F02 344 H2AFB2 BC101415 H2A histone family, member B2 pANT7_cGST 705813 HsxXG014245 15 G02 371 CCDC153 BC101443 coiled-coil domain containing 153 pANT7_cGST 705814 HsxXG014245 16 H02 377 PPP1R11 BC102010 protein phosphatase 1, regulatory (inhibitor) subunit 11 pANT7_cGST 705815 HsxXG014245 17 A03 524 DLX6 BC103688 distal-less homeobox 6 pANT7_cGST 705816 HsxXG014245 18 B03 524 DLX6 BC103690 distal-less homeobox 6 pANT7_cGST 705817 HsxXG014245 19 C03 524 DLX6 BC109381 distal-less homeobox 6 pANT7_cGST 705818 HsxXG014245 20 D03 416 VCX2 BC104153 variable charge, X-linked 2 pANT7_cGST 705821 HsxXG014245 21 E03 494 PLA2G10 BC111804 phospholipase A2, group X pANT7_cGST 705825 HsxXG014245 22 F03 566 IFNA7 BC114000 interferon, alpha 7 pANT7_cGST 705827 HsxXG014245 23 G03 1406 PRR5-ARHGAP8 BC132755 PRR5-ARHGAP8 readthrough pANT7_cGST 705831 HsxXG014245 24 H03 1859 SLC6A6 BC137128 solute carrier family 6 (neurotransmitter transporter), memberpANT7_cGST 705840 HsxXG014245 25 A04 734 KRTAP10-12 BC137339 keratin associated protein 10-12 pANT7_cGST 705854 HsxXG014245 26 B04 278 CCL3L1 BC146914 chemokine (C-C motif) ligand 3-like 1 pANT7_cGST 705859 HsxXG014245 27 C04 824 FAM166B BC146933 family with sequence similarity 166, member B pANT7_cGST 705864 HsxXG014245 28 D04 278 CCL3L3 BC147013 chemokine (C-C motif) ligand 3-like 3 pANT7_cGST 705866 HsxXG014245 29 E04 278 CCL3L3 BC147008 chemokine (C-C motif) ligand 3-like 3 pANT7_cGST 705869 HsxXG014245 30 F04 266 FAM25C BC146989 family with sequence similarity 25, member C pANT7_cGST 705870 HsxXG014245 31 G04 878 RPS2 BC068051 ribosomal protein S2 pANT7_cGST 705873 HsxXG014245 32 H04 878 RPS2 BC075830 ribosomal protein S2 pANT7_cGST 705874 HsxXG014245 33 A05 878 RPS2 BC071923 ribosomal protein S2 pANT7_cGST

Camacho-Encina M, et al. Ann Rheum Dis 2019; 0:1699ÿý1705. doi: 10.1136/annrheumdis-2019-215325 Supplementary material Ann Rheum Dis

705875 HsxXG014245 34 B05 959 HNRNPA1 BC071945 heterogeneous nuclear ribonucleoprotein A1 pANT7_cGST 705876 HsxXG014245 35 C05 878 RPS2 BC071922 ribosomal protein S2 pANT7_cGST 705877 HsxXG014245 36 D05 878 RPS2 BC071924 ribosomal protein S2 pANT7_cGST 705882 HsxXG014245 37 E05 692 SNRPB BC080516 small nuclear ribonucleoprotein polypeptides B and B1 pANT7_cGST 705888 HsxXG014245 38 F05 1196 MBOAT7 BC015857 membrane bound O-acyltransferase domain containing 7 pANT7_cGST 705889 HsxXG014245 39 G05 647 DCAF16 BC068025 DDB1 and CUL4 associated factor 16 pANT7_cGST 705890 HsxXG014245 40 H05 746 TPI1 BC017917 triosephosphate isomerase 1 pANT7_cGST 705894 HsxXG014245 41 A06 677 LAPTM4B BC031021 lysosomal protein transmembrane 4 beta pANT7_cGST 705895 HsxXG014245 42 B06 851 GPN3 BC031024 GPN-loop GTPase 3 pANT7_cGST 705899 HsxXG014245 43 C06 584 SELT BC006012 selenoprotein T pANT7_cGST 705901 HsxXG014245 44 D06 560 VTCN1 BC065717 V-set domain containing T cell activation inhibitor 1 pANT7_cGST 705903 HsxXG014245 45 E06 1754 MCMDC2 BC063108 minichromosome maintenance domain containing 2 pANT7_cGST 705904 HsxXG014245 46 F06 293 RNASEK BC062705 ribonuclease, RNase K pANT7_cGST 705905 HsxXG014245 47 G06 374 RPL31 BC070373 ribosomal protein L31 pANT7_cGST 705908 HsxXG014245 48 H06 278 HIGD1A BC070277 HIG1 hypoxia inducible domain family, member 1A pANT7_cGST 705910 HsxXG014245 49 A07 959 HNRNPA1 BC070315 heterogeneous nuclear ribonucleoprotein A1 pANT7_cGST 705912 HsxXG014245 50 B07 419 MED22 BC024225 mediator complex subunit 22 pANT7_cGST 705914 HsxXG014245 51 C07 656 NGRN BC017192 neugrin, neurite outgrowth associated pANT7_cGST 705916 HsxXG014245 52 D07 1247 TLE6 BC013986 transducin-like enhancer of split 6 (E(sp1) homolog, DrosophipANT7_cGST 705917 HsxXG014245 53 E07 650 HYI BC006140 hydroxypyruvate isomerase (putative) pANT7_cGST 705918 HsxXG014245 54 F07 719 EFHD2 BC023611 EF-hand domain family, member D2 pANT7_cGST 705919 HsxXG014245 55 G07 1529 INTS4 BC015664 integrator complex subunit 4 pANT7_cGST 705920 HsxXG014245 56 H07 569 GPX2 BC022820 glutathione peroxidase 2 (gastrointestinal) pANT7_cGST 705923 HsxXG014245 57 A08 419 LYPD6B BC018203 LY6/PLAUR domain containing 6B pANT7_cGST 705925 HsxXG014245 58 B08 491 ZNF321P BC046449 zinc finger protein 321, pseudogene pANT7_cGST 705929 HsxXG014245 59 C08 1484 FERMT1 BC035882 fermitin family member 1 pANT7_cGST 705930 HsxXG014245 60 D08 260 SEPW1 BC032546 selenoprotein W, 1 pANT7_cGST 705931 HsxXG014245 61 E08 434 SELM BC030236 selenoprotein M pANT7_cGST 705932 HsxXG014245 62 F08 1214 TBC1D16 BC036947 TBC1 domain family, member 16 pANT7_cGST 705934 HsxXG014245 63 G08 623 ADORA3 BC041707 adenosine A3 receptor pANT7_cGST 705936 HsxXG014245 64 H08 1151 SUCLG2 BC047024 succinate-CoA ligase, GDP-forming, beta subunit pANT7_cGST 705937 HsxXG014245 65 A09 353 ZNF767 BC047675 zinc finger family member 767 pANT7_cGST 705938 HsxXG014245 66 B09 1067 RBMY1A1 BC047768 RNA binding motif protein, Y-linked, family 1, member A1 pANT7_cGST 705940 HsxXG014245 67 C09 860 STPG1 BC047705 sperm-tail PG-rich repeat containing 1 pANT7_cGST 705942 HsxXG014245 68 D09 1256 IKBKG BC000299 inhibitor of kappa light polypeptide gene enhancer in B-cells,pANT7_cGST 705943 HsxXG014245 69 E09 455 NME1 BC000293 NME/NM23 nucleoside diphosphate kinase 1 pANT7_cGST 705945 HsxXG014245 70 F09 959 HNRNPA1 BC002355 heterogeneous nuclear ribonucleoprotein A1 pANT7_cGST 705948 HsxXG014245 71 G09 443 RNF24 BC000213 ring finger protein 24 pANT7_cGST

Camacho-Encina M, et al. Ann Rheum Dis 2019; 0:1699ÿý1705. doi: 10.1136/annrheumdis-2019-215325 Supplementary material Ann Rheum Dis

705949 HsxXG014245 72 H09 485 CCDC28A BC004464 coiled-coil domain containing 28A pANT7_cGST 705950 HsxXG014245 73 A10 656 NGRN BC001682 neugrin, neurite outgrowth associated pANT7_cGST 705952 HsxXG014245 74 B10 257 SNRPF BC002505 small nuclear ribonucleoprotein polypeptide F pANT7_cGST 705953 HsxXG014245 75 C10 1469 CLK3 BC002555 CDC-like kinase 3 pANT7_cGST 705954 HsxXG014245 76 D10 272 UQCRH BC001426 ubiquinol-cytochrome c reductase hinge protein pANT7_cGST 705956 HsxXG014245 77 E10 293 S100A13 BC000632 S100 calcium binding protein A13 pANT7_cGST 705961 HsxXG014245 78 F10 611 DLK2 BC000230 delta-like 2 homolog (Drosophila) pANT7_cGST 705963 HsxXG014245 79 G10 728 MACROD1 BC003188 MACRO domain containing 1 pANT7_cGST 705964 HsxXG014245 80 H10 548 SRSF10 BC001107 serine/arginine-rich splicing factor 10 pANT7_cGST 705965 HsxXG014245 81 A11 701 KCTD15 BC001185 potassium channel tetramerisation domain containing 15 pANT7_cGST 705969 HsxXG014245 82 B11 719 U2AF1 BC001923 U2 small nuclear RNA auxiliary factor 1 pANT7_cGST 705970 HsxXG014245 83 C11 1652 EPS8L1 BC004907 EPS8-like 1 pANT7_cGST 705971 HsxXG014245 84 D11 665 CHAC1 BC001683 ChaC, cation transport regulator homolog 1 (E. coli) pANT7_cGST 705973 HsxXG014245 85 E11 314 RPL36 BC004971 ribosomal protein L36 pANT7_cGST 705974 HsxXG014245 86 F11 1544 MTA3 BC004227 metastasis associated 1 family, member 3 pANT7_cGST 711607 HsxXG014245 87 G11 923 HAGH BC002627 hydroxyacylglutathione hydrolase pANT7_cGST 711608 HsxXG014245 88 H11 947 PRMT6 BC002729 protein arginine methyltransferase 6 pANT7_cGST 711609 HsxXG014245 89 A12 851 PEF1 BC002773 penta-EF-hand domain containing 1 pANT7_cGST 711610 HsxXG014245 90 B12 347 VAMP2 BC002737 vesicle-associated membrane protein 2 (synaptobrevin 2) pANT7_cGST 711613 HsxXG014245 91 C12 1040 JUNB BC004250 jun B proto-oncogene pANT7_cGST 711615 HsxXG014245 92 D12 344 RPLP2 BC005354 ribosomal protein, large, P2 pANT7_cGST 711616 HsxXG014245 93 E12 830 IMPA1 BC008381 inositol(myo)-1(or 4)-monophosphatase 1 pANT7_cGST 711617 HsxXG014245 94 F12 299 VAMP3 BC007050 vesicle-associated membrane protein 3 pANT7_cGST 711621 HsxXG014245 95 G12 626 ZSCAN31 BC008490 zinc finger and SCAN domain containing 31 pANT7_cGST HsxXG014245 96 H12 pANT7_cGST HsxXG014246 1 A01 pANT7_cGST 711625 HsxXG014246 2 B01 746 TPI1 BC007086 triosephosphate isomerase 1 pANT7_cGST 711629 HsxXG014246 3 C01 878 RPS2 BC006559 ribosomal protein S2 pANT7_cGST 711632 HsxXG014246 4 D01 440 PPP1R14B BC014522 protein phosphatase 1, regulatory (inhibitor) subunit 14B pANT7_cGST 711633 HsxXG014246 5 E01 884 STARD7 BC014274 StAR-related lipid transfer (START) domain containing 7 pANT7_cGST 711634 HsxXG014246 6 F01 668 C17orf59 BC018880 chromosome 17 open reading frame 59 pANT7_cGST 711635 HsxXG014246 7 G01 746 TPI1 BC011611 triosephosphate isomerase 1 pANT7_cGST 711637 HsxXG014246 8 H01 1271 SF3B4 BC013886 splicing factor 3b, subunit 4, 49kDa pANT7_cGST 711639 HsxXG014246 9 A02 476 UBE2W BC010900 ubiquitin-conjugating enzyme E2W (putative) pANT7_cGST 711640 HsxXG014246 10 B02 359 TMEM230 BC009768 transmembrane protein 230 pANT7_cGST 711643 HsxXG014246 11 C02 278 HIGD1A BC009583 HIG1 hypoxia inducible domain family, member 1A pANT7_cGST 711644 HsxXG014246 12 D02 959 HNRNPA1 BC009600 heterogeneous nuclear ribonucleoprotein A1 pANT7_cGST 711645 HsxXG014246 13 E02 1754 UBE3A BC009271 ubiquitin protein ligase E3A pANT7_cGST

Camacho-Encina M, et al. Ann Rheum Dis 2019; 0:1699ÿý1705. doi: 10.1136/annrheumdis-2019-215325 Supplementary material Ann Rheum Dis

711648 HsxXG014246 14 F02 878 RPS2 BC021545 ribosomal protein S2 pANT7_cGST 711649 HsxXG014246 15 G02 884 STARD7 BC012774 StAR-related lipid transfer (START) domain containing 7 pANT7_cGST 711650 HsxXG014246 16 H02 557 SPATC1L BC009497 spermatogenesis and centriole associated 1-like pANT7_cGST 711653 HsxXG014246 17 A03 884 STARD7 BC012793 StAR-related lipid transfer (START) domain containing 7 pANT7_cGST 711654 HsxXG014246 18 B03 746 TPI1 BC009329 triosephosphate isomerase 1 pANT7_cGST 711656 HsxXG014246 19 C03 1154 SLC18A1 BC009387 solute carrier family 18 (vesicular monoamine), member 1 pANT7_cGST 711659 HsxXG014246 20 D03 428 H2AFX BC011694 H2A histone family, member X pANT7_cGST 711663 HsxXG014246 21 E03 878 RPS2 BC010165 ribosomal protein S2 pANT7_cGST 711664 HsxXG014246 22 F03 884 STARD7 BC014076 StAR-related lipid transfer (START) domain containing 7 pANT7_cGST 711666 HsxXG014246 23 G03 959 HNRNPA1 BC012158 heterogeneous nuclear ribonucleoprotein A1 pANT7_cGST 711669 HsxXG014246 24 H03 1691 KRT6A BC014152 keratin 6A pANT7_cGST 711671 HsxXG014246 25 A04 443 PRR13 BC014257 proline rich 13 pANT7_cGST 711675 HsxXG014246 26 B04 410 ITGB3BP BC014385 integrin beta 3 binding protein (beta3-endonexin) pANT7_cGST 711676 HsxXG014246 27 C04 329 TMEM126B BC017574 transmembrane protein 126B pANT7_cGST 711678 HsxXG014246 28 D04 725 NDFIP2 BC021988 Nedd4 family interacting protein 2 pANT7_cGST 711681 HsxXG014246 29 E04 644 ARL6IP4 BC015569 ADP-ribosylation-like factor 6 interacting protein 4 pANT7_cGST 711684 HsxXG014246 30 F04 791 ZNF524 BC014666 zinc finger protein 524 pANT7_cGST 711686 HsxXG014246 31 G04 374 RPL31 BC017343 ribosomal protein L31 pANT7_cGST 711688 HsxXG014246 32 H04 1346 TLE6 BC020206 transducin-like enhancer of split 6 (E(sp1) homolog, DrosophipANT7_cGST 711690 HsxXG014246 33 A05 575 RNF185 BC009504 ring finger protein 185 pANT7_cGST 711691 HsxXG014246 34 B05 1031 TRIM44 BC024031 tripartite motif containing 44 pANT7_cGST 711692 HsxXG014246 35 C05 1094 FBXL18 BC024256 F-box and leucine-rich repeat protein 18 pANT7_cGST 711693 HsxXG014246 36 D05 878 RPS2 BC023541 ribosomal protein S2 pANT7_cGST 711694 HsxXG014246 37 E05 1577 FUS BC026062 fused in sarcoma pANT7_cGST 711695 HsxXG014246 38 F05 374 GFER BC028348 growth factor, augmenter of liver regeneration pANT7_cGST 711697 HsxXG014246 39 G05 1505 WDR48 BC037168 WD repeat domain 48 pANT7_cGST 711698 HsxXG014246 40 H05 884 STARD7 BC032106 StAR-related lipid transfer (START) domain containing 7 pANT7_cGST 711699 HsxXG014246 41 A06 878 RPS2 BC032129 ribosomal protein S2 pANT7_cGST 711702 HsxXG014246 42 B06 1139 RBFOX2 BC025281 RNA binding protein, fox-1 homolog (C. elegans) 2 pANT7_cGST 705976 HsxXG014246 43 C06 881 TRIM4 BC025949 tripartite motif containing 4 pANT7_cGST 705978 HsxXG014246 44 D06 356 OSTCP1 BC024224 oligosaccharyltransferase complex subunit pseudogene 1 pANT7_cGST 705979 HsxXG014246 45 E06 398 SZRD1 BC023988 SUZ RNA binding domain containing 1 pANT7_cGST 705982 HsxXG014246 46 F06 1769 KRT5 BC042132 keratin 5 pANT7_cGST 705985 HsxXG014246 47 G06 428 LAGE3 BC062330 L antigen family, member 3 pANT7_cGST 705986 HsxXG014246 48 H06 1079 BLOC1S5-TXNDC5 BC052310 BLOC1S5-TXNDC5 readthrough (non-protein coding) pANT7_cGST 705987 HsxXG014246 49 A07 569 GPX2 BC005277 glutathione peroxidase 2 (gastrointestinal) pANT7_cGST 705989 HsxXG014246 50 B07 293 S100A13 BC070291 S100 calcium binding protein A13 pANT7_cGST 705990 HsxXG014246 51 C07 1331 TUBB BC070326 tubulin, beta class I pANT7_cGST

Camacho-Encina M, et al. Ann Rheum Dis 2019; 0:1699ÿý1705. doi: 10.1136/annrheumdis-2019-215325 Supplementary material Ann Rheum Dis

705994 HsxXG014246 52 D07 272 UQCRH BC107703 ubiquinol-cytochrome c reductase hinge protein pANT7_cGST 705995 HsxXG014246 53 E07 242 NEDD8 BC104664 neural precursor cell expressed, developmentally down-regulpANT7_cGST 705996 HsxXG014246 54 F07 296 CCL7 BC092436 chemokine (C-C motif) ligand 7 pANT7_cGST 705997 HsxXG014246 55 G07 467 CUTA BC107751 cutA divalent cation tolerance homolog (E. coli) pANT7_cGST 705998 HsxXG014246 56 H07 497 PRH2 BC095488 proline-rich protein HaeIII subfamily 2 pANT7_cGST 705999 HsxXG014246 57 A08 386 LLPH BC107780 LLP homolog, long-term synaptic facilitation (Aplysia) pANT7_cGST 706000 HsxXG014246 58 B08 875 NME1-NME2 BC107894 NME1-NME2 readthrough pANT7_cGST 706004 HsxXG014246 59 C08 959 HNRNPA1 BC052296 heterogeneous nuclear ribonucleoprotein A1 pANT7_cGST 706009 HsxXG014246 60 D08 680 PCMT1 BC008748 protein-L-isoaspartate (D-aspartate) O-methyltransferase pANT7_cGST 706014 HsxXG014246 61 E08 1082 ZBTB37 BC006315 zinc finger and BTB domain containing 37 pANT7_cGST 706016 HsxXG014246 62 F08 1592 PKM BC007952 pyruvate kinase, muscle pANT7_cGST 706017 HsxXG014246 63 G08 584 MARCKSL1 BC007904 MARCKS-like 1 pANT7_cGST 706018 HsxXG014246 64 H08 803 PITPNC1 BC007905 phosphatidylinositol transfer protein, cytoplasmic 1 pANT7_cGST 706019 HsxXG014246 65 A09 917 ZNF625 BC007868 zinc finger protein 625 pANT7_cGST 706021 HsxXG014246 66 B09 344 RPLP2 BC007573 ribosomal protein, large, P2 pANT7_cGST 706023 HsxXG014246 67 C09 1325 IFRD2 BC007265 interferon-related developmental regulator 2 pANT7_cGST 706025 HsxXG014246 68 D09 1424 TRIM62 BC007999 tripartite motif containing 62 pANT7_cGST 706026 HsxXG014246 69 E09 878 RPS2 BC008862 ribosomal protein S2 pANT7_cGST 706028 HsxXG014246 70 F09 947 NSMCE4A BC005212 non-SMC element 4 homolog A (S. cerevisiae) pANT7_cGST 706033 HsxXG014246 71 G09 512 MBP BC143350 myelin basic protein pANT7_cGST 706037 HsxXG014246 72 H09 1217 TPRN BC143385 taperin pANT7_cGST 706038 HsxXG014246 73 A10 350 GAGE12B BC143615 G antigen 12B pANT7_cGST 706040 HsxXG014246 74 B10 1199 ZNF514 BC074901 zinc finger protein 514 pANT7_cGST 706045 HsxXG014246 75 C10 1160 GALR2 BC074914 galanin receptor 2 pANT7_cGST 706047 HsxXG014246 76 D10 1190 P2RX3 BC074793 purinergic receptor P2X, ligand-gated ion channel, 3 pANT7_cGST 706051 HsxXG014246 77 E10 422 CST4 BC074953 cystatin S pANT7_cGST 706056 HsxXG014246 78 F10 1634 TCERG1L BC093639 transcription elongation regulator 1-like pANT7_cGST 706061 HsxXG014246 79 G10 578 CBLN1 BC093718 cerebellin 1 precursor pANT7_cGST 706062 HsxXG014246 80 H10 248 PDE6H BC093740 phosphodiesterase 6H, cGMP-specific, cone, gamma pANT7_cGST 706064 HsxXG014246 81 A11 605 LIF BC093735 leukemia inhibitory factor pANT7_cGST 706068 HsxXG014246 82 B11 1526 SCARB1 BC093732 scavenger receptor class B, member 1 pANT7_cGST 706071 HsxXG014246 83 C11 281 DEFA1 BC093791 defensin, alpha 1 pANT7_cGST 706072 HsxXG014246 84 D11 1598 TBC1D10B BC093814 TBC1 domain family, member 10B pANT7_cGST 706073 HsxXG014246 85 E11 293 KRTAP3-3 BC093845 keratin associated protein 3-3 pANT7_cGST 706076 HsxXG014246 86 F11 356 CXCL17 BC093946 chemokine (C-X-C motif) ligand 17 pANT7_cGST 706081 HsxXG014246 87 G11 1184 TRIM10 BC093926 tripartite motif containing 10 pANT7_cGST 706082 HsxXG014246 88 H11 203 OAZ1 BC093652 ornithine decarboxylase antizyme 1 pANT7_cGST 706085 HsxXG014246 89 A12 1910 R3HDM2 BC104995 R3H domain containing 2 pANT7_cGST

Camacho-Encina M, et al. Ann Rheum Dis 2019; 0:1699ÿý1705. doi: 10.1136/annrheumdis-2019-215325 Supplementary material Ann Rheum Dis

706086 HsxXG014246 90 B12 1910 R3HDM2 BC112226 R3H domain containing 2 pANT7_cGST 706088 HsxXG014246 91 C12 296 CCL7 BC112260 chemokine (C-C motif) ligand 7 pANT7_cGST 706092 HsxXG014246 92 D12 1151 TYW1 BC051888 tRNA-yW synthesizing protein 1 homolog (S. cerevisiae) pANT7_cGST 706093 HsxXG014246 93 E12 1217 RING1 BC051866 ring finger protein 1 pANT7_cGST 706096 HsxXG014246 94 F12 1172 PLEKHA8P1 BC063575 pleckstrin homology domain containing, family A member 8 pANT7_cGSTps 706097 HsxXG014246 95 G12 1127 GPATCH2 BC063474 G patch domain containing 2 pANT7_cGST HsxXG014246 96 H12 pANT7_cGST HsxXG014273 1 A01 pANT7_cGST 677091 HsxXG014273 2 B01 2822 ERAP1 endoplasmic reticulum aminopeptidase 1 pANT7_cGST 677093 HsxXG014273 3 C01 2819 XPC xeroderma pigmentosum, complementation group C pANT7_cGST 677262 HsxXG014273 4 D01 1964 SRPK1 SRSF protein kinase 1 pANT7_cGST 677280 HsxXG014273 5 E01 1940 CEP72 centrosomal protein 72kDa pANT7_cGST 677288 HsxXG014273 6 F01 1931 INPP5E inositol polyphosphate-5-phosphatase, 72 kDa pANT7_cGST 677348 HsxXG014273 7 G01 671 CRP C-reactive protein, pentraxin-related pANT7_cGST 637219 HsxXG014273 8 H01 323 GRO-beta M36820 pANT7_cGST 637220 HsxXG014273 9 A02 341 D15057 pANT7_cGST 637221 HsxXG014273 10 B02 428 BC034148 pANT7_cGST 637226 HsxXG014273 11 C02 596 NKEFB L19185 pANT7_cGST 637230 HsxXG014273 12 D02 665 L06895 pANT7_cGST 637236 HsxXG014273 13 E02 938 Ich-1 U13022 pANT7_cGST 637238 HsxXG014273 14 F02 953 IBSP J05213 pANT7_cGST 637239 HsxXG014273 15 G02 1040 X05908 pANT7_cGST 637246 HsxXG014273 16 H02 1562 OXCT U62961 pANT7_cGST 637251 HsxXG014273 17 A03 347 MIF NM_002415 pANT7_cGST 637252 HsxXG014273 18 B03 404 ID2 NM_002166 pANT7_cGST 637254 HsxXG014273 19 C03 575 ARHG NM_001665 pANT7_cGST 637258 HsxXG014273 20 D03 782 GDB M36532 pANT7_cGST 637259 HsxXG014273 21 E03 782 DCK NM_000788 pANT7_cGST 637263 HsxXG014273 22 F03 482 TNNC2 NM_003279 pANT7_cGST 637267 HsxXG014273 23 G03 485 TNNC1 BC030244 pANT7_cGST 637269 HsxXG014273 24 H03 509 EREG NM_001432 pANT7_cGST 637270 HsxXG014273 25 A04 545 CD160 BC014465 pANT7_cGST 637271 HsxXG014273 26 B04 443 HBB NM_000518 pANT7_cGST 637276 HsxXG014273 27 C04 1256 BAAT NM_001701 pANT7_cGST 637280 HsxXG014273 28 D04 635 GDNF NM_000514 pANT7_cGST 637281 HsxXG014273 29 E04 743 YWHAG BC020963 pANT7_cGST 637285 HsxXG014273 30 F04 992 GRAP2 BC025692 pANT7_cGST 637288 HsxXG014273 31 G04 857 STAR BC010550 pANT7_cGST

Camacho-Encina M, et al. Ann Rheum Dis 2019; 0:1699ÿý1705. doi: 10.1136/annrheumdis-2019-215325 Supplementary material Ann Rheum Dis

637293 HsxXG014273 32 H04 803 POMC NM_000939 pANT7_cGST 637295 HsxXG014273 33 A05 812 VDRIP NM_014166 pANT7_cGST 637298 HsxXG014273 34 B05 821 HLA-DOB BC006097 pANT7_cGST 637301 HsxXG014273 35 C05 827 TPSB1 NM_003294 pANT7_cGST 637304 HsxXG014273 36 D05 950 HMOX2 BC002396 pANT7_cGST 637305 HsxXG014273 37 E05 833 RSU1 BC008691 pANT7_cGST 637308 HsxXG014273 38 F05 842 HRY NM_005524 pANT7_cGST 637312 HsxXG014273 39 G05 596 PRDX2 BC039428 pANT7_cGST 637315 HsxXG014273 40 H05 1133 ACTA1 BC012597 pANT7_cGST 637316 HsxXG014273 41 A06 596 DUSP14 BC004448 pANT7_cGST 637319 HsxXG014273 42 B06 1007 POLB NM_002690 pANT7_cGST 637324 HsxXG014273 43 C06 389 KCNE1 NM_000219 pANT7_cGST 637327 HsxXG014273 44 D06 1049 CTGF AY395801 pANT7_cGST 637339 HsxXG014273 45 E06 1148 PRELP BC032498 pANT7_cGST 637340 HsxXG014273 46 F06 959 GPR55 BC032694 pANT7_cGST 637341 HsxXG014273 47 G06 665 RAB27A NM_183234 pANT7_cGST 637342 HsxXG014273 48 H06 677 BC060858 pANT7_cGST 637345 HsxXG014273 49 A07 1022 DNAJB1 BC002352 pANT7_cGST 637349 HsxXG014273 50 B07 647 AY113186 pANT7_cGST 637350 HsxXG014273 51 C07 1034 TOB2 BC038957 pANT7_cGST 637351 HsxXG014273 52 D07 608 PTTG1 NM_004219 pANT7_cGST 637352 HsxXG014273 53 E07 611 RAB13 NM_002870 pANT7_cGST 637363 HsxXG014273 54 F07 656 RAB11B AF498947 pANT7_cGST 637364 HsxXG014273 55 G07 851 MTAP NM_002451 pANT7_cGST 637372 HsxXG014273 56 H07 395 MIA NM_006533 pANT7_cGST 637374 HsxXG014273 57 A08 1088 GPR4 NM_005282 pANT7_cGST 637376 HsxXG014273 58 B08 719 PSME2 NM_002818 pANT7_cGST 637383 HsxXG014273 59 C08 617 LTA BC034729 pANT7_cGST 637384 HsxXG014273 60 D08 812 HOXA5 NM_019102 pANT7_cGST 637385 HsxXG014273 61 E08 815 FOSL1 BC016648 pANT7_cGST 637386 HsxXG014273 62 F08 1355 FARS1 NM_006567 pANT7_cGST 637408 HsxXG014273 63 G08 1016 FOSB NM_006732 pANT7_cGST 637409 HsxXG014273 64 H08 1058 SH3GL2 NM_003026 pANT7_cGST 637411 HsxXG014273 65 A09 383 FABP1 BC032801 pANT7_cGST 637423 HsxXG014273 66 B09 761 CD151 BC013302 pANT7_cGST 637428 HsxXG014273 67 C09 386 SH2D1A BC020732 pANT7_cGST 637430 HsxXG014273 68 D09 743 PEX11A BC009697 pANT7_cGST 637440 HsxXG014273 69 E09 752 TNFSF13 NM_003808 pANT7_cGST

Camacho-Encina M, et al. Ann Rheum Dis 2019; 0:1699ÿý1705. doi: 10.1136/annrheumdis-2019-215325 Supplementary material Ann Rheum Dis

637441 HsxXG014273 70 F09 1052 PLEK BC018549 pANT7_cGST 637442 HsxXG014273 71 G09 1103 UROD BC001778 pANT7_cGST 637445 HsxXG014273 72 H09 1112 OPRL1 BC038433 pANT7_cGST 637446 HsxXG014273 73 A10 1121 PEX3 BC015506 pANT7_cGST 637447 HsxXG014273 74 B10 404 NPPB BC025785 pANT7_cGST 637448 HsxXG014273 75 C10 584 AK1 NM_000476 pANT7_cGST 637453 HsxXG014273 76 D10 632 TNNI3 M64247 pANT7_cGST 637454 HsxXG014273 77 E10 638 DTYMK BC001827 pANT7_cGST 637461 HsxXG014273 78 F10 797 AQP5 BC032946 pANT7_cGST 637462 HsxXG014273 79 G10 815 AQP2 BC042496 pANT7_cGST 637469 HsxXG014273 80 H10 563 GDB J04760 pANT7_cGST 637472 HsxXG014273 81 A11 497 DSTN BC009477 pANT7_cGST 637473 HsxXG014273 82 B11 500 MYL2 BC031006 pANT7_cGST 637477 HsxXG014273 83 C11 1127 hsp-D X65018 pANT7_cGST 637479 HsxXG014273 84 D11 464 ID1 NM_002165 pANT7_cGST 637480 HsxXG014273 85 E11 1406 IL6R NM_000565 pANT7_cGST 637481 HsxXG014273 86 F11 1409 ETS2 NM_005239 pANT7_cGST 637483 HsxXG014273 87 G11 1703 TGFBR2 NM_003242 pANT7_cGST 637484 HsxXG014273 88 H11 953 NFKBIA NM_020529 pANT7_cGST 637488 HsxXG014273 89 A12 680 GJB2 NM_004004 pANT7_cGST 637490 HsxXG014273 90 B12 1367 TNFRSF1A NM_001065 pANT7_cGST 637493 HsxXG014273 91 C12 446 GRP NM_002091 pANT7_cGST 637496 HsxXG014273 92 D12 887 SULT1A1 NM_001055 pANT7_cGST 637497 HsxXG014273 93 E12 1820 ARAF1 NM_001654 pANT7_cGST 637498 HsxXG014273 94 F12 866 IFI35 BC001356 pANT7_cGST 637507 HsxXG014273 95 G12 971 CCNH NM_001239 pANT7_cGST HsxXG014273 96 H12 pANT7_cGST HsxXG014274 1 A01 pANT7_cGST 637509 HsxXG014274 2 B01 293 COX6A2 NM_005205 pANT7_cGST 637512 HsxXG014274 3 C01 392 PEA15 NM_003768 pANT7_cGST 637514 HsxXG014274 4 D01 1295 SGK NM_005627 pANT7_cGST 637520 HsxXG014274 5 E01 1364 BMP5 NM_021073 pANT7_cGST 637525 HsxXG014274 6 F01 1064 WNT11 NM_004626 pANT7_cGST 637531 HsxXG014274 7 G01 323 GRO1 NM_001511 pANT7_cGST 637532 HsxXG014274 8 H01 344 SCYB6 NM_002993 pANT7_cGST 637541 HsxXG014274 9 A02 569 IFNA21 NM_002175 pANT7_cGST 634027 HsxXG014274 10 B02 1043 MAP2K BC032478.1 pANT7_cGST 634033 HsxXG014274 11 C02 2663 BC033004.1 pANT7_cGST

Camacho-Encina M, et al. Ann Rheum Dis 2019; 0:1699ÿý1705. doi: 10.1136/annrheumdis-2019-215325 Supplementary material Ann Rheum Dis

634035 HsxXG014274 12 D02 2843 MAP3K1 BC035576.1 pANT7_cGST 634037 HsxXG014274 13 E02 1247 CSNK1G2 BC020972.1 pANT7_cGST 634038 HsxXG014274 14 F02 2696 JIK BC002756.1 pANT7_cGST 634046 HsxXG014274 15 G02 1574 G BC037549.1 pANT7_cGST 634050 HsxXG014274 16 H02 1409 PFKFB BC010269.1 pANT7_cGST 634052 HsxXG014274 17 A03 1775 PAK4 BC011368.1 pANT7_cGST 634053 HsxXG014274 18 B03 1811 BC011392.1 pANT7_cGST 634054 HsxXG014274 19 C03 1811 PLK BC014846.1 pANT7_cGST 634055 HsxXG014274 20 D03 1631 CHEK2 BC004207.1 pANT7_cGST 634056 HsxXG014274 21 E03 911 CDK4 BC003644.1 pANT7_cGST 634059 HsxXG014274 22 F03 2201 RPS6KA2 BC002363.1 pANT7_cGST 634060 HsxXG014274 23 G03 1202 MAP2K2 BC000471.1 pANT7_cGST 634061 HsxXG014274 24 H03 1619 LCK BC013200.1 pANT7_cGST 634064 HsxXG014274 25 A04 1256 ALS2CR2 BC008302.1 pANT7_cGST 634066 HsxXG014274 26 B04 1301 STK11 BC007981.1 pANT7_cGST 634067 HsxXG014274 27 C04 1421 BC016695.1 pANT7_cGST 634068 HsxXG014274 28 D04 3020 PTK BC035404.2 pANT7_cGST 634069 HsxXG014274 29 E04 1985 BC035782.1 pANT7_cGST 634074 HsxXG014274 30 F04 1280 BC038295.1 pANT7_cGST 634080 HsxXG014274 31 G04 584 AK1 BC001116.1 pANT7_cGST 634082 HsxXG014274 32 H04 956 PRPS1 BC001605.1 pANT7_cGST 634086 HsxXG014274 33 A05 2066 SRPK BC035214.1 pANT7_cGST 634088 HsxXG014274 34 B05 1436 CAMK2 BC032784.1 pANT7_cGST 634091 HsxXG014274 35 C05 2159 PAK BC024179.1 pANT7_cGST 634095 HsxXG014274 36 D05 896 CDK2 BC003065.1 pANT7_cGST 634096 HsxXG014274 37 E05 1037 ADK BC003568.1 pANT7_cGST 634097 HsxXG014274 38 F05 1778 BC014270.1 pANT7_cGST 634098 HsxXG014274 39 G05 1055 PRKAC BC039888.1 pANT7_cGST 634099 HsxXG014274 40 H05 1253 CKMT1 BC001926.1 pANT7_cGST 634101 HsxXG014274 41 A06 1964 SPHK2 BC006161.1 pANT7_cGST 634102 HsxXG014274 42 B06 1250 CSNK1E BC006490.1 pANT7_cGST 634104 HsxXG014274 43 C06 1139 BC013992.1 pANT7_cGST 634105 HsxXG014274 44 D06 686 BC014961.1 pANT7_cGST 634106 HsxXG014274 45 E06 3563 BC014243.1 pANT7_cGST 634114 HsxXG014274 46 F06 584 NM23-H6 BC001808.1 pANT7_cGST 634119 HsxXG014274 47 G06 1235 PDK BC040239.1 pANT7_cGST 634124 HsxXG014274 48 H06 1103 BC015741.1 pANT7_cGST 634134 HsxXG014274 49 A07 1190 MVK BC016140.1 pANT7_cGST

Camacho-Encina M, et al. Ann Rheum Dis 2019; 0:1699ÿý1705. doi: 10.1136/annrheumdis-2019-215325 Supplementary material Ann Rheum Dis

634136 HsxXG014274 50 B07 1220 PHKG2 BC002541.1 pANT7_cGST 634139 HsxXG014274 51 C07 2270 MLH1 BC006850.1 pANT7_cGST 634144 HsxXG014274 52 D07 1583 BC034044.1 pANT7_cGST 634155 HsxXG014274 53 E07 1562 CAMKK BC031647.1 pANT7_cGST 634161 HsxXG014274 54 F07 1598 BC028383.1 pANT7_cGST 634165 HsxXG014274 55 G07 1607 NRBP BC001221.1 pANT7_cGST 634167 HsxXG014274 56 H07 3707 BC014036.1 pANT7_cGST 634172 HsxXG014274 57 A08 2930 EPHA BC037166.2 pANT7_cGST 634173 HsxXG014274 58 B08 1724 PKL BC025737.1 pANT7_cGST 634175 HsxXG014274 59 C08 2684 AX BC032229.1 pANT7_cGST 634176 HsxXG014274 60 D08 1310 PDK BC039158.1 pANT7_cGST 634177 HsxXG014274 61 E08 2462 FGFR BC018128.1 pANT7_cGST 634178 HsxXG014274 62 F08 1661 GK BC029820.1 pANT7_cGST 634183 HsxXG014274 63 G08 2045 PAK BC035596.1 pANT7_cGST 634184 HsxXG014274 64 H08 1649 BC030587.1 pANT7_cGST 634185 HsxXG014274 65 A09 2051 BC037268.1 pANT7_cGST 634188 HsxXG014274 66 B09 1295 PLAU BC013575.1 pANT7_cGST 634189 HsxXG014274 67 C09 1397 GCK BC001890.1 pANT7_cGST 634190 HsxXG014274 68 D09 1145 CKM BC007462.1 pANT7_cGST 645505 HsxXG014274 69 E09 815 PITPNB CR456541 pANT7_cGST 645523 HsxXG014274 70 F09 923 SLC25A17 CR456577 pANT7_cGST 645538 HsxXG014274 71 G09 635 TIMP3 CR456593 pANT7_cGST 645553 HsxXG014274 72 H09 380 SNRPD3 CR456583 pANT7_cGST 645573 HsxXG014274 73 A10 725 PDGFB CR456538 pANT7_cGST 645579 HsxXG014274 74 B10 1118 Em CT841507 pANT7_cGST 645602 HsxXG014274 75 C10 2204 MCM5 CR456517 pANT7_cGST 645610 HsxXG014274 76 D10 965 MFNG CR456518 pANT7_cGST 645617 HsxXG014274 77 E10 1337 KCNJ4 CR456507 pANT7_cGST 645618 HsxXG014274 78 F10 1601 MGAT3 CR456519 pANT7_cGST 645631 HsxXG014274 79 G10 992 GRAP2 CR456498 pANT7_cGST 645636 HsxXG014274 80 H10 1271 Em CR456350 pANT7_cGST 645647 HsxXG014274 81 A11 734 GSTT2 CR456500 pANT7_cGST 645663 HsxXG014274 82 B11 2162 GTSE1 CT841519 pANT7_cGST 645672 HsxXG014274 83 C11 5882 MYH9 CR456526 pANT7_cGST 645702 HsxXG014274 84 D11 614 dJ347H13.5 CR456459 pANT7_cGST 656754 HsxXG014274 85 E11 1358 BC009395.1 pANT7_cGST 656756 HsxXG014274 86 F11 1568 BC014020.1 pANT7_cGST 656757 HsxXG014274 87 G11 1787 BC011913.1 pANT7_cGST

Camacho-Encina M, et al. Ann Rheum Dis 2019; 0:1699ÿý1705. doi: 10.1136/annrheumdis-2019-215325 Supplementary material Ann Rheum Dis

656758 HsxXG014274 88 H11 2408 BC011847.1 pANT7_cGST 656760 HsxXG014274 89 A12 413 BC010173.1 pANT7_cGST 656762 HsxXG014274 90 B12 764 BC011678.1 pANT7_cGST 656763 HsxXG014274 91 C12 803 APOA1 BC005380.1 pANT7_cGST 656767 HsxXG014274 92 D12 1220 BC009585.1 pANT7_cGST 656771 HsxXG014274 93 E12 1598 ZBRK1 BC009921.1 pANT7_cGST 656772 HsxXG014274 94 F12 2426 BC014081.1 pANT7_cGST 656773 HsxXG014274 95 G12 287 BC008450.1 pANT7_cGST HsxXG014274 96 H12 pANT7_cGST HsxXG014275 1 A01 pANT7_cGST 656774 HsxXG014275 2 B01 428 BC009363.1 pANT7_cGST 656775 HsxXG014275 3 C01 545 ARL1 BC007000.1 pANT7_cGST 656777 HsxXG014275 4 D01 767 BC014460.1 pANT7_cGST 656781 HsxXG014275 5 E01 1232 SIGIRR BC003591.1 pANT7_cGST 656782 HsxXG014275 6 F01 1283 BC009960.1 pANT7_cGST 656788 HsxXG014275 7 G01 317 HCS BC005299.1 pANT7_cGST 656791 HsxXG014275 8 H01 776 BC014006.1 pANT7_cGST 656792 HsxXG014275 9 A02 812 HSPC126 BC005189.1 pANT7_cGST 656793 HsxXG014275 10 B02 1016 MDH2 BC001917.1 pANT7_cGST 656797 HsxXG014275 11 C02 1289 BC011899.1 pANT7_cGST 656798 HsxXG014275 12 D02 1418 SLC38A5 BC019246.1 pANT7_cGST 656799 HsxXG014275 13 E02 1502 BC015628.1 pANT7_cGST 656801 HsxXG014275 14 F02 1961 TRIM32 BC003154.1 pANT7_cGST 656802 HsxXG014275 15 G02 2804 PCDHGC3 BC019299.1 pANT7_cGST 656803 HsxXG014275 16 H02 326 BC011932.1 pANT7_cGST 656804 HsxXG014275 17 A03 479 SDHD BC005263.1 pANT7_cGST 656806 HsxXG014275 18 B03 719 BC011909.1 pANT7_cGST 656807 HsxXG014275 19 C03 782 BC009956.1 pANT7_cGST 656808 HsxXG014275 20 D03 839 FHL2 BC014397.1 pANT7_cGST 656814 HsxXG014275 21 E03 1517 GRP58 BC014433.1 pANT7_cGST 656820 HsxXG014275 22 F03 722 GSTT1 BC007065.1 pANT7_cGST 656821 HsxXG014275 23 G03 788 BC015739.1 pANT7_cGST 656822 HsxXG014275 24 H03 845 BC017502.1 pANT7_cGST 656824 HsxXG014275 25 A04 1091 RFC4 BC017452.1 pANT7_cGST 656826 HsxXG014275 26 B04 1259 FDP BC010004.1 pANT7_cGST 656827 HsxXG014275 27 C04 1355 BC015752.1 pANT7_cGST 656828 HsxXG014275 28 D04 1433 BC015625.1 pANT7_cGST 656832 HsxXG014275 29 E04 4331 BC017232.1 pANT7_cGST

Camacho-Encina M, et al. Ann Rheum Dis 2019; 0:1699ÿý1705. doi: 10.1136/annrheumdis-2019-215325 Supplementary material Ann Rheum Dis

656835 HsxXG014275 30 F04 650 RAB11A BC013348.1 pANT7_cGST 656837 HsxXG014275 31 G04 788 KLK1 BC005313.1 pANT7_cGST 656838 HsxXG014275 32 H04 845 DC8 BC007067.1 pANT7_cGST 656841 HsxXG014275 33 A05 1436 VTN BC005046.1 pANT7_cGST 656842 HsxXG014275 34 B05 1550 DHCR24 BC004375.1 pANT7_cGST 656843 HsxXG014275 35 C05 1709 GGT BC025927.1 pANT7_cGST 656846 HsxXG014275 36 D05 458 BC010175.1 pANT7_cGST 635812 HsxXG014275 37 E05 722 BC018991.1 pANT7_cGST 635838 HsxXG014275 38 F05 341 SUI1 BC005118.1 pANT7_cGST 635842 HsxXG014275 39 G05 926 COPE BC003155.1 pANT7_cGST 635843 HsxXG014275 40 H05 944 APG BC024221.2 pANT7_cGST 635846 HsxXG014275 41 A06 1220 PYGO BC032099.2 pANT7_cGST 635853 HsxXG014275 42 B06 407 BC009407.1 pANT7_cGST 635854 HsxXG014275 43 C06 533 BC018970.1 pANT7_cGST 635855 HsxXG014275 44 D06 713 TGIF BC012816.2 pANT7_cGST 635860 HsxXG014275 45 E06 1142 FOS BC004490.1 pANT7_cGST 635864 HsxXG014275 46 F06 1757 BC011885.1 pANT7_cGST 635865 HsxXG014275 47 G06 2123 MMP9 BC006093.1 pANT7_cGST 635883 HsxXG014275 48 H06 554 DUSP2 BC022847.2 pANT7_cGST 635906 HsxXG014275 49 A07 2405 PRDM BC035581.1 pANT7_cGST 635907 HsxXG014275 50 B07 2876 BC039245.1 pANT7_cGST 635910 HsxXG014275 51 C07 575 CDC42 BC003682.1 pANT7_cGST 635913 HsxXG014275 52 D07 896 BC037273.1 pANT7_cGST 635915 HsxXG014275 53 E07 1133 GNA1 BC036756.1 pANT7_cGST 635916 HsxXG014275 54 F07 1211 STK15 BC001280.1 pANT7_cGST 635938 HsxXG014275 55 G07 581 AP3S1 BC000804.1 pANT7_cGST 635940 HsxXG014275 56 H07 1013 BC028723.1 pANT7_cGST 635943 HsxXG014275 57 A08 1268 GFI BC032751.1 pANT7_cGST 635947 HsxXG014275 58 B08 2009 BC036518.1 pANT7_cGST 635951 HsxXG014275 59 C08 584 BC000802.1 pANT7_cGST 635953 HsxXG014275 60 D08 797 BC032946.1 pANT7_cGST 635954 HsxXG014275 61 E08 1028 HAN11 BC001264.1 pANT7_cGST 635956 HsxXG014275 62 F08 1154 BC036657.1 pANT7_cGST 635961 HsxXG014275 63 G08 1868 GALNT BC035822.1 pANT7_cGST 635962 HsxXG014275 64 H08 2198 LS BC035638.1 pANT7_cGST 635965 HsxXG014275 65 A09 494 DU BC033645.1 pANT7_cGST 635970 HsxXG014275 66 B09 1106 SH3GL1 BC001270.1 pANT7_cGST 635973 HsxXG014275 67 C09 1226 ACY1 BC000545.1 pANT7_cGST

Camacho-Encina M, et al. Ann Rheum Dis 2019; 0:1699ÿý1705. doi: 10.1136/annrheumdis-2019-215325 Supplementary material Ann Rheum Dis

635974 HsxXG014275 68 D09 1322 BC011655.1 pANT7_cGST 635975 HsxXG014275 69 E09 1370 DDOST BC002594.1 pANT7_cGST 635976 HsxXG014275 70 F09 155 RPL39 BC001019.1 pANT7_cGST 635980 HsxXG014275 71 G09 755 BC009566.1 pANT7_cGST 635982 HsxXG014275 72 H09 926 GPSN2 BC002425.1 pANT7_cGST 635983 HsxXG014275 73 A10 1076 BC013313.1 pANT7_cGST 635984 HsxXG014275 74 B10 1106 BGN BC002416.1 pANT7_cGST 635985 HsxXG014275 75 C10 1256 BC009567.1 pANT7_cGST 635986 HsxXG014275 76 D10 1331 BC021195.1 pANT7_cGST 635991 HsxXG014275 77 E10 227 BC015563.1 pANT7_cGST 635992 HsxXG014275 78 F10 413 NDUFB7 BC002595.1 pANT7_cGST 635994 HsxXG014275 79 G10 764 PSME3 BC001423.1 pANT7_cGST 635996 HsxXG014275 80 H10 926 BC011645.1 pANT7_cGST 635997 HsxXG014275 81 A11 986 P2RY6 BC000571.1 pANT7_cGST 635998 HsxXG014275 82 B11 1076 TKT BC002578.1 pANT7_cGST 636001 HsxXG014275 83 C11 1343 BC018905.1 pANT7_cGST 636002 HsxXG014275 84 D11 1430 MMP10 BC002591.1 pANT7_cGST 636004 HsxXG014275 85 E11 1982 MMP2 BC002576.1 pANT7_cGST 636006 HsxXG014275 86 F11 260 COX6B BC001015.1 pANT7_cGST 636009 HsxXG014275 87 G11 767 BC009944.1 pANT7_cGST 636010 HsxXG014275 88 H11 878 BC011616.1 pANT7_cGST 636013 HsxXG014275 89 A12 1094 OAS1 BC000562.1 pANT7_cGST 636014 HsxXG014275 90 B12 1127 BC011634.1 pANT7_cGST 636016 HsxXG014275 91 C12 1349 PCOLCE BC000574.1 pANT7_cGST 636017 HsxXG014275 92 D12 1433 BC009748.1 pANT7_cGST 636018 HsxXG014275 93 E12 2078 SLC21A11 BC000585.1 pANT7_cGST 636024 HsxXG014275 94 F12 941 MGLL BC000551.1 pANT7_cGST 636025 HsxXG014275 95 G12 1022 GNB3 BC002454.1 pANT7_cGST HsxXG014275 96 H12 pANT7_cGST HsxXG014276 1 A01 pANT7_cGST 636028 HsxXG014276 2 B01 1277 F2R BC002464.1 pANT7_cGST 636029 HsxXG014276 3 C01 1355 TUBG1 BC000619.1 pANT7_cGST 636032 HsxXG014276 4 D01 2573 TTK BC000633.1 pANT7_cGST 636034 HsxXG014276 5 E01 446 RAMP1 BC000548.1 pANT7_cGST 636036 HsxXG014276 6 F01 686 BC021214.1 pANT7_cGST 636037 HsxXG014276 7 G01 797 UROS BC002573.1 pANT7_cGST 636043 HsxXG014276 8 H01 1286 HDAC3 BC000614.1 pANT7_cGST 636051 HsxXG014276 9 A02 734 QDPR BC000576.1 pANT7_cGST

Camacho-Encina M, et al. Ann Rheum Dis 2019; 0:1699ÿý1705. doi: 10.1136/annrheumdis-2019-215325 Supplementary material Ann Rheum Dis

636052 HsxXG014276 10 B02 827 RRP40 BC002437.1 pANT7_cGST 636054 HsxXG014276 11 C02 956 BC013973.1 pANT7_cGST 636056 HsxXG014276 12 D02 1337 EIF3S6 BC000734.1 pANT7_cGST 636060 HsxXG014276 13 E02 2294 BF BC004143.1 pANT7_cGST 636065 HsxXG014276 14 F02 650 PPIB BC001125.1 pANT7_cGST 636066 HsxXG014276 15 G02 785 BC012106.1 pANT7_cGST 636072 HsxXG014276 16 H02 1352 PAX8 BC001060.1 pANT7_cGST 636078 HsxXG014276 17 A03 440 PPIL BC030142.2 pANT7_cGST 636082 HsxXG014276 18 B03 866 HMOX1 BC001491.1 pANT7_cGST 636087 HsxXG014276 19 C03 1505 BC001692.1 pANT7_cGST 636133 HsxXG014276 20 D03 986 MSI2 BC001526.1 pANT7_cGST 636149 HsxXG014276 21 E03 1307 ORC5 BC023652.2 pANT7_cGST 636152 HsxXG014276 22 F03 1871 ABCF2 BC001661.1 pANT7_cGST 636155 HsxXG014276 23 G03 2807 MTHFD1 BC009806.1 pANT7_cGST 636156 HsxXG014276 24 H03 407 LGALS1 BC001693.1 pANT7_cGST 636163 HsxXG014276 25 A04 1205 TNFRSF11 BC030155.2 pANT7_cGST 636166 HsxXG014276 26 B04 1907 BC012355.1 pANT7_cGST 636169 HsxXG014276 27 C04 416 CRABP2 BC001109.1 pANT7_cGST 636172 HsxXG014276 28 D04 959 OR2C BC030717.1 pANT7_cGST 636176 HsxXG014276 29 E04 1688 PLAT BC007231.1 pANT7_cGST 636178 HsxXG014276 30 F04 2159 BC013375.1 pANT7_cGST 636179 HsxXG014276 31 G04 203 POLR2L BC005903.1 pANT7_cGST 636180 HsxXG014276 32 H04 431 ETV BC022868.1 pANT7_cGST 636181 HsxXG014276 33 A05 509 COX4I1 BC008704.1 pANT7_cGST 636182 HsxXG014276 34 B05 581 ARHC BC007245.1 pANT7_cGST 636183 HsxXG014276 35 C05 659 HSPC177 BC006974.1 pANT7_cGST 636186 HsxXG014276 36 D05 1028 P2RY1 BC017898.1 pANT7_cGST 636095 HsxXG014276 37 E05 1343 TEAD2 BC007556.1 pANT7_cGST 636098 HsxXG014276 38 F05 1691 BC007581.1 pANT7_cGST 636099 HsxXG014276 39 G05 1910 BC015958.1 pANT7_cGST 636102 HsxXG014276 40 H05 434 PLA2G2A BC005919.1 pANT7_cGST 636103 HsxXG014276 41 A06 509 BC012731.1 pANT7_cGST 636104 HsxXG014276 42 B06 599 PRDX1 BC007063.1 pANT7_cGST 636108 HsxXG014276 43 C06 1280 INHBA BC007858.1 pANT7_cGST 636111 HsxXG014276 44 D06 1532 BC010423.1 pANT7_cGST 636112 HsxXG014276 45 E06 1763 MGC15548 BC007263.1 pANT7_cGST 636114 HsxXG014276 46 F06 2567 HCNP BC007208.1 pANT7_cGST 636116 HsxXG014276 47 G06 443 HBB BC007075.1 pANT7_cGST

Camacho-Encina M, et al. Ann Rheum Dis 2019; 0:1699ÿý1705. doi: 10.1136/annrheumdis-2019-215325 Supplementary material Ann Rheum Dis

636118 HsxXG014276 48 H06 734 CKAP1 BC005969.1 pANT7_cGST 636119 HsxXG014276 49 A07 851 VDAC1 BC008482.1 pANT7_cGST 636120 HsxXG014276 50 B07 911 STUB1 BC007545.1 pANT7_cGST 636124 HsxXG014276 51 C07 1388 GTF2H4 BC004935.1 pANT7_cGST 636126 HsxXG014276 52 D07 1535 AMY2A BC007060.1 pANT7_cGST 636128 HsxXG014276 53 E07 2018 CAPN10 BC004260.1 pANT7_cGST 636190 HsxXG014276 54 F07 605 BC009200.1 pANT7_cGST 636192 HsxXG014276 55 G07 851 GJB2 BC002805.1 pANT7_cGST 636193 HsxXG014276 56 H07 923 HSPC228 BC006989.1 pANT7_cGST 636194 HsxXG014276 57 A08 1064 CA1 BC023981.1 pANT7_cGST 636195 HsxXG014276 58 B08 1262 KREMEN2 BC003533.1 pANT7_cGST 636196 HsxXG014276 59 C08 1391 UBE1 BC022853.1 pANT7_cGST 636202 HsxXG014276 60 D08 377 BC018634.1 pANT7_cGST 636205 HsxXG014276 61 E08 623 NFYB BC005317.1 pANT7_cGST 636206 HsxXG014276 62 F08 854 HOXB13 BC007092.1 pANT7_cGST 636207 HsxXG014276 63 G08 935 BC009196.1 pANT7_cGST 636210 HsxXG014276 64 H08 1316 NOT56L BC002839.1 pANT7_cGST 636211 HsxXG014276 65 A09 1466 BC007294.1 pANT7_cGST 636212 HsxXG014276 66 B09 1616 BC007580.1 pANT7_cGST 636214 HsxXG014276 67 C09 2102 MYBL2 BC007585.1 pANT7_cGST 636215 HsxXG014276 68 D09 3797 PLCG2 BC007565.1 pANT7_cGST 636221 HsxXG014276 69 E09 1184 BC009828.1 pANT7_cGST 636222 HsxXG014276 70 F09 1229 ARRB2 BC007427.1 pANT7_cGST 636223 HsxXG014276 71 G09 1394 BC015645.1 pANT7_cGST 636225 HsxXG014276 72 H09 1682 KNS2 BC008881.1 pANT7_cGST 636231 HsxXG014276 73 A10 728 MYF BC017834.1 pANT7_cGST 636233 HsxXG014276 74 B10 953 MC1R BC007856.1 pANT7_cGST 636234 HsxXG014276 75 C10 1121 BC009861.1 pANT7_cGST 636237 HsxXG014276 76 D10 1424 GSS BC007927.1 pANT7_cGST 636241 HsxXG014276 77 E10 230 PKI BC022265.2 pANT7_cGST 636245 HsxXG014276 78 F10 749 BC007812.1 pANT7_cGST 636247 HsxXG014276 79 G10 977 BC009483.1 pANT7_cGST 636250 HsxXG014276 80 H10 1199 CASQ BC022288.1 pANT7_cGST 636255 HsxXG014276 81 A11 2144 BC008751.1 pANT7_cGST 636257 HsxXG014276 82 B11 287 BC009192.1 pANT7_cGST 636260 HsxXG014276 83 C11 638 BOK BC006203.1 pANT7_cGST 636268 HsxXG014276 84 D11 1778 ATIC BC008879.1 pANT7_cGST 636274 HsxXG014276 85 E11 863 SLC25A10 BC007355.1 pANT7_cGST

Camacho-Encina M, et al. Ann Rheum Dis 2019; 0:1699ÿý1705. doi: 10.1136/annrheumdis-2019-215325 Supplementary material Ann Rheum Dis

636275 HsxXG014276 86 F11 1055 ATP6V0D1 BC008861.1 pANT7_cGST 636277 HsxXG014276 87 G11 1175 RBMX BC007435.1 pANT7_cGST 636278 HsxXG014276 88 H11 1220 SERPINA5 BC008915.1 pANT7_cGST 657961 HsxXG014276 89 A12 1184 BC021161.1 pANT7_cGST 657967 HsxXG014276 90 B12 377 BC017112.1 pANT7_cGST 657973 HsxXG014276 91 C12 1055 ATF4 BC008090.1 pANT7_cGST 657974 HsxXG014276 92 D12 1145 PRKAR1 BC036285.1 pANT7_cGST 657978 HsxXG014276 93 E12 1562 OXCT BC009001.1 pANT7_cGST 657984 HsxXG014276 94 F12 644 KDELR3 BC001277.1 pANT7_cGST 657986 HsxXG014276 95 G12 956 APEX BC008145.1 pANT7_cGST HsxXG014276 96 H12 pANT7_cGST HsxXG014277 1 A01 pANT7_cGST 657987 HsxXG014277 2 B01 1040 SAE1 BC018271.1 pANT7_cGST 657988 HsxXG014277 3 C01 1148 PPM1 BC026691.1 pANT7_cGST 657989 HsxXG014277 4 D01 1250 PSTPIP1 BC008602.1 pANT7_cGST 658000 HsxXG014277 5 E01 983 CACNG BC034532.1 pANT7_cGST 657947 HsxXG014277 6 F01 1172 ESAM BC016868.1 pANT7_cGST 657908 HsxXG014277 7 G01 1280 IHPK BC019694.1 pANT7_cGST 657909 HsxXG014277 8 H01 1406 TNFRSF10A BC012866.1 pANT7_cGST 657911 HsxXG014277 9 A02 1670 GPC BC017166.1 pANT7_cGST 657913 HsxXG014277 10 B02 428 HBA2 BC008572.1 pANT7_cGST 657929 HsxXG014277 11 C02 671 DNAJB BC028912.1 pANT7_cGST 657936 HsxXG014277 12 D02 1418 EIF2S BC019906.1 pANT7_cGST 636381 HsxXG014277 13 E02 587 PGRMC BC034238.1 pANT7_cGST 636383 HsxXG014277 14 F02 680 GJB2 BC017048.1 pANT7_cGST 636384 HsxXG014277 15 G02 833 TNFRSF5 BC012419.1 pANT7_cGST 636390 HsxXG014277 16 H02 1808 SLC13A BC035966.1 pANT7_cGST 636391 HsxXG014277 17 A03 1973 EDE BC019088.1 pANT7_cGST 636392 HsxXG014277 18 B03 2381 SF3A1 BC007684.1 pANT7_cGST 636394 HsxXG014277 19 C03 497 PPIA BC000689.1 pANT7_cGST 636399 HsxXG014277 20 D03 1124 TRAM BC000687.1 pANT7_cGST 636400 HsxXG014277 21 E03 1202 BC017305.1 pANT7_cGST 636401 HsxXG014277 22 F03 1253 BC021288.1 pANT7_cGST 636402 HsxXG014277 23 G03 1313 BC019094.1 pANT7_cGST 636403 HsxXG014277 24 H03 1451 KRT8 BC000654.1 pANT7_cGST 636405 HsxXG014277 25 A04 1820 ARAF1 BC002466.1 pANT7_cGST 636407 HsxXG014277 26 B04 2582 BC017282.1 pANT7_cGST 636408 HsxXG014277 27 C04 410 H3F3 BC029405.1 pANT7_cGST

Camacho-Encina M, et al. Ann Rheum Dis 2019; 0:1699ÿý1705. doi: 10.1136/annrheumdis-2019-215325 Supplementary material Ann Rheum Dis

636409 HsxXG014277 28 D04 659 PIG BC029408.1 pANT7_cGST 636410 HsxXG014277 29 E04 998 DYT1 BC000674.1 pANT7_cGST 636411 HsxXG014277 30 F04 1091 ADA BC007678.1 pANT7_cGST 636412 HsxXG014277 31 G04 1130 ACTR1A BC000693.1 pANT7_cGST 636413 HsxXG014277 32 H04 1274 AMSH BC007682.1 pANT7_cGST 636419 HsxXG014277 33 A05 437 BC017360.1 pANT7_cGST 636420 HsxXG014277 34 B05 575 BC014261.1 pANT7_cGST 636422 HsxXG014277 35 C05 815 ICAM BC029364.1 pANT7_cGST 636424 HsxXG014277 36 D05 1094 GDF BC030959.1 pANT7_cGST 636425 HsxXG014277 37 E05 1139 BC017292.1 pANT7_cGST 636431 HsxXG014277 38 F05 3323 POLD1 BC008800.1 pANT7_cGST 636438 HsxXG014277 39 G05 1160 BC019035.1 pANT7_cGST 636443 HsxXG014277 40 H05 1700 CDC45L BC006232.1 pANT7_cGST 636445 HsxXG014277 41 A06 2309 ITGB2 BC005861.1 pANT7_cGST 636447 HsxXG014277 42 B06 377 BC017343.1 pANT7_cGST 636448 HsxXG014277 43 C06 473 RPL24 BC000690.1 pANT7_cGST 636456 HsxXG014277 44 D06 1304 BC017249.1 pANT7_cGST 636457 HsxXG014277 45 E06 1565 BC017355.1 pANT7_cGST 636458 HsxXG014277 46 F06 1733 BC017293.1 pANT7_cGST 636470 HsxXG014277 47 G06 1667 EPHX2 BC007708.1 pANT7_cGST 636471 HsxXG014277 48 H06 1838 OS-9 BC000532.1 pANT7_cGST 636475 HsxXG014277 49 A07 578 RPL9 BC000483.1 pANT7_cGST 636476 HsxXG014277 50 B07 632 BC010915.1 pANT7_cGST 636479 HsxXG014277 51 C07 1073 SORD BC021085.1 pANT7_cGST 636481 HsxXG014277 52 D07 1247 B3GNT6 BC021965.1 pANT7_cGST 636483 HsxXG014277 53 E07 1856 DIBD1 BC009255.1 pANT7_cGST 636484 HsxXG014277 54 F07 2000 76P BC012801.1 pANT7_cGST 636485 HsxXG014277 55 G07 2291 HADHA BC009235.1 pANT7_cGST 636492 HsxXG014277 56 H07 1295 BC001011.1 pANT7_cGST 636493 HsxXG014277 57 A08 1370 BC021217.1 pANT7_cGST 636494 HsxXG014277 58 B08 1481 SLC18A1 BC006317.1 pANT7_cGST 636495 HsxXG014277 59 C08 1604 APPBP1 BC000480.1 pANT7_cGST 636498 HsxXG014277 60 D08 2399 ITGB5 BC006541.1 pANT7_cGST 636507 HsxXG014277 61 E08 1382 CHRM1 BC007740.1 pANT7_cGST 636512 HsxXG014277 62 F08 2162 GTSE1 BC006325.1 pANT7_cGST 636513 HsxXG014277 63 G08 2492 BC011656.1 pANT7_cGST 636515 HsxXG014277 64 H08 542 IGF2 BC000531.1 pANT7_cGST 636516 HsxXG014277 65 A09 596 BC009778.1 pANT7_cGST

Camacho-Encina M, et al. Ann Rheum Dis 2019; 0:1699ÿý1705. doi: 10.1136/annrheumdis-2019-215325 Supplementary material Ann Rheum Dis

636523 HsxXG014277 66 B09 1625 EHD4 BC006287.1 pANT7_cGST 636524 HsxXG014277 67 C09 1769 PPP2R1A BC001537.1 pANT7_cGST 636526 HsxXG014277 68 D09 2219 GARS BC007755.1 pANT7_cGST 636528 HsxXG014277 69 E09 491 BC009785.1 pANT7_cGST 636529 HsxXG014277 70 F09 545 ATF3 BC006322.1 pANT7_cGST 636535 HsxXG014277 71 G09 1229 BC012605.1 pANT7_cGST 636536 HsxXG014277 72 H09 1343 MGAT2 BC006390.1 pANT7_cGST 636539 HsxXG014277 73 A10 1637 TRIP10 BC013002.1 pANT7_cGST 636541 HsxXG014277 74 B10 2282 PIGQ BC006377.1 pANT7_cGST 636543 HsxXG014277 75 C10 569 BC017218.1 pANT7_cGST 636544 HsxXG014277 76 D10 623 FGF18 BC006245.1 pANT7_cGST 636548 HsxXG014277 77 E10 1127 BC013327.1 pANT7_cGST 636549 HsxXG014277 78 F10 1202 PSCD2 BC004361.1 pANT7_cGST 636552 HsxXG014277 79 G10 1568 NUP62 BC003663.1 pANT7_cGST 636564 HsxXG014277 80 H10 1271 IVD BC017202.1 pANT7_cGST 636565 HsxXG014277 81 A11 1454 SUFU BC013291.1 pANT7_cGST 636570 HsxXG014277 82 B11 224 GNGT BC029367.1 pANT7_cGST 636574 HsxXG014277 83 C11 749 NDUFV2 BC001632.1 pANT7_cGST 636577 HsxXG014277 84 D11 1157 IDH3B BC001960.1 pANT7_cGST 636584 HsxXG014277 85 E11 506 BAD BC001901.1 pANT7_cGST 636597 HsxXG014277 86 F11 635 TIMP3 BC014277.1 pANT7_cGST 636599 HsxXG014277 87 G11 860 RNASEH1 BC002973.1 pANT7_cGST 636602 HsxXG014277 88 H11 1178 BCAT2 BC001900.1 pANT7_cGST 636604 HsxXG014277 89 A12 1358 FLI1 BC001670.1 pANT7_cGST 636607 HsxXG014277 90 B12 2342 BC014092.1 pANT7_cGST 636608 HsxXG014277 91 C12 3362 BC012151.1 pANT7_cGST 636609 HsxXG014277 92 D12 410 RPL27 BC001700.1 pANT7_cGST 636612 HsxXG014277 93 E12 701 FRAT2 BC020165.1 pANT7_cGST 636618 HsxXG014277 94 F12 1259 TERF BC029378.1 pANT7_cGST 636620 HsxXG014277 95 G12 1559 BC014097.1 pANT7_cGST HsxXG014277 96 H12 pANT7_cGST HsxXG014278 1 A01 pANT7_cGST 636621 HsxXG014278 2 B01 1673 BC012325.1 pANT7_cGST 636622 HsxXG014278 3 C01 1976 ENG BC014271.1 pANT7_cGST 636623 HsxXG014278 4 D01 2351 BC014417.1 pANT7_cGST 636628 HsxXG014278 5 E01 905 SLC25A20 BC001689.1 pANT7_cGST 636630 HsxXG014278 6 F01 1232 LAMP2 BC002965.1 pANT7_cGST 636631 HsxXG014278 7 G01 1337 MGAT1 BC003575.1 pANT7_cGST

Camacho-Encina M, et al. Ann Rheum Dis 2019; 0:1699ÿý1705. doi: 10.1136/annrheumdis-2019-215325 Supplementary material Ann Rheum Dis

636638 HsxXG014278 8 H01 317 RPL36 BC003052.1 pANT7_cGST 636644 HsxXG014278 9 A02 1121 H105E3 BC000245.1 pANT7_cGST 636652 HsxXG014278 10 B02 320 GLRX BC005304.1 pANT7_cGST 636653 HsxXG014278 11 C02 368 SAA1 BC007022.1 pANT7_cGST 636654 HsxXG014278 12 D02 623 MEL BC002977.1 pANT7_cGST 636655 HsxXG014278 13 E02 737 BC012347.1 pANT7_cGST 636656 HsxXG014278 14 F02 902 SPP1 BC007016.1 pANT7_cGST 653953 HsxXG014278 15 G02 1664 MGC2663 BC001791.1 pANT7_cGST 653956 HsxXG014278 16 H02 2561 PDE6B BC000249.1 pANT7_cGST 653957 HsxXG014278 17 A03 344 SCYB5 BC008376.1 pANT7_cGST 653959 HsxXG014278 18 B03 635 FKBP14 BC005206.1 pANT7_cGST 653960 HsxXG014278 19 C03 740 PSMA6 BC002979.1 pANT7_cGST 653962 HsxXG014278 20 D03 1268 IL11RA BC003110.1 pANT7_cGST 653963 HsxXG014278 21 E03 1367 EPHX1 BC003567.1 pANT7_cGST 653968 HsxXG014278 22 F03 284 SCYB11 BC005292.1 pANT7_cGST 653970 HsxXG014278 23 G03 437 UBE2V2 BC007051.1 pANT7_cGST 653972 HsxXG014278 24 H03 635 BAK1 BC004431.1 pANT7_cGST 653973 HsxXG014278 25 A04 758 BC011589.1 pANT7_cGST 653974 HsxXG014278 26 B04 953 APOE BC003557.1 pANT7_cGST 653976 HsxXG014278 27 C04 1181 TP53 BC003596.1 pANT7_cGST 653977 HsxXG014278 28 D04 1277 RBBP4 BC003092.1 pANT7_cGST 653982 HsxXG014278 29 E04 2753 BC021116.1 pANT7_cGST 653983 HsxXG014278 30 F04 302 APOA2 BC005282.1 pANT7_cGST 653984 HsxXG014278 31 G04 344 TCL1A BC003574.1 pANT7_cGST 653986 HsxXG014278 32 H04 536 NAT5 BC005181.1 pANT7_cGST 653987 HsxXG014278 33 A05 785 PSMA4 BC005361.1 pANT7_cGST 653990 HsxXG014278 34 B05 1181 B4GALT3 BC000276.1 pANT7_cGST 653992 HsxXG014278 35 C05 1397 MADH1 BC001878.1 pANT7_cGST 653993 HsxXG014278 36 D05 1748 FLN29 BC003553.1 pANT7_cGST 653995 HsxXG014278 37 E05 2333 HGS BC003565.1 pANT7_cGST 653999 HsxXG014278 38 F05 542 GCG BC005278.1 pANT7_cGST 654001 HsxXG014278 39 G05 809 FKSG14 BC005400.1 pANT7_cGST 654002 HsxXG014278 40 H05 977 IL10RB BC001903.1 pANT7_cGST 654010 HsxXG014278 41 A06 983 GBL BC020499.1 pANT7_cGST 654012 HsxXG014278 42 B06 1436 BC025991.1 pANT7_cGST 654020 HsxXG014278 43 C06 407 RPL3 BC011514.1 pANT7_cGST 654027 HsxXG014278 44 D06 1436 BC030693.1 pANT7_cGST 654029 HsxXG014278 45 E06 1589 ATP5 BC016512.1 pANT7_cGST

Camacho-Encina M, et al. Ann Rheum Dis 2019; 0:1699ÿý1705. doi: 10.1136/annrheumdis-2019-215325 Supplementary material Ann Rheum Dis

654033 HsxXG014278 46 F06 245 RPS21 BC018140.1 pANT7_cGST 654036 HsxXG014278 47 G06 764 HLA-DR BC032350.1 pANT7_cGST 654039 HsxXG014278 48 H06 1193 BC030579.1 pANT7_cGST 654041 HsxXG014278 49 A07 1442 BC030589.1 pANT7_cGST 636663 HsxXG014278 50 B07 791 RPS4 BC010286.1 pANT7_cGST 636666 HsxXG014278 51 C07 1358 IL BC001554.1 pANT7_cGST 636675 HsxXG014278 52 D07 317 BC025399.1 pANT7_cGST 636677 HsxXG014278 53 E07 794 SNAI BC012910.1 pANT7_cGST 636682 HsxXG014278 54 F07 1505 TRAF BC032410.1 pANT7_cGST 636686 HsxXG014278 55 G07 2012 RAD1 BC032304.1 pANT7_cGST 636689 HsxXG014278 56 H07 3044 ADPR BC037545.1 pANT7_cGST 636693 HsxXG014278 57 A08 803 MSX2 BC015509.1 pANT7_cGST 636697 HsxXG014278 58 B08 1268 PAX6 BC011953.1 pANT7_cGST 636698 HsxXG014278 59 C08 1349 BC010514.1 pANT7_cGST 636700 HsxXG014278 60 D08 1517 FR BC012916.1 pANT7_cGST 636701 HsxXG014278 61 E08 1628 GALNACT- BC030268.1 pANT7_cGST 636703 HsxXG014278 62 F08 221 GNG11 BC009709.1 pANT7_cGST 636710 HsxXG014278 63 G08 977 CYC1 BC020566.1 pANT7_cGST 636715 HsxXG014278 64 H08 1529 DNT BC012920.1 pANT7_cGST 636720 HsxXG014278 65 A09 398 IFITM2 BC009696.1 pANT7_cGST 636721 HsxXG014278 66 B09 497 LMO4 BC017673.1 pANT7_cGST 636722 HsxXG014278 67 C09 635 RPL13 BC013078.1 pANT7_cGST 636725 HsxXG014278 68 D09 842 DAPP BC012924.1 pANT7_cGST 636729 HsxXG014278 69 E09 1370 RUVBL1 BC012886.1 pANT7_cGST 636732 HsxXG014278 70 F09 1700 CES1 BC012418.1 pANT7_cGST 636734 HsxXG014278 71 G09 2531 PYGB BC017045.1 pANT7_cGST 636739 HsxXG014278 72 H09 896 SLC25A6 BC014775.1 pANT7_cGST 636743 HsxXG014278 73 A10 1388 BC009733.1 pANT7_cGST 636744 HsxXG014278 74 B10 1559 DC BC028311.1 pANT7_cGST 636750 HsxXG014278 75 C10 566 RPL18 BC009708.1 pANT7_cGST 636751 HsxXG014278 76 D10 638 IL6 BC015511.1 pANT7_cGST 636754 HsxXG014278 77 E10 1010 HIBAD BC032324.1 pANT7_cGST 636755 HsxXG014278 78 F10 1244 ITPK1 BC018192.1 pANT7_cGST 636756 HsxXG014278 79 G10 1304 ENO1 BC011130.1 pANT7_cGST 636758 HsxXG014278 80 H10 1574 CYP4F11 BC016853.1 pANT7_cGST 636759 HsxXG014278 81 A11 1766 TAF1B BC018137.1 pANT7_cGST 636760 HsxXG014278 82 B11 2057 RNF BC034688.2 pANT7_cGST 636761 HsxXG014278 83 C11 311 G0S2 BC009694.1 pANT7_cGST

Camacho-Encina M, et al. Ann Rheum Dis 2019; 0:1699ÿý1705. doi: 10.1136/annrheumdis-2019-215325 Supplementary material Ann Rheum Dis

636762 HsxXG014278 84 D11 476 PRG1 BC015516.1 pANT7_cGST 636763 HsxXG014278 85 E11 572 SLC31A1 BC013611.1 pANT7_cGST 636768 HsxXG014278 86 F11 1505 CHRNB1 BC011371.1 pANT7_cGST 636774 HsxXG014278 87 G11 641 EBAG9 BC017729.1 pANT7_cGST 636775 HsxXG014278 88 H11 710 CDC34 BC018143.1 pANT7_cGST 636779 HsxXG014278 89 A12 1391 EEF1A2 BC000432.1 pANT7_cGST 636780 HsxXG014278 90 B12 1472 CYP2C BC020596.1 pANT7_cGST 636783 HsxXG014278 91 C12 191 COX7C BC001005.1 pANT7_cGST 636784 HsxXG014278 92 D12 371 RPL35 BC000348.1 pANT7_cGST 636785 HsxXG014278 93 E12 530 MCE BC020825.1 pANT7_cGST 636787 HsxXG014278 94 F12 710 BC002341.1 pANT7_cGST 636791 HsxXG014278 95 G12 1127 SEL BC020758.1 pANT7_cGST HsxXG014278 96 H12 pANT7_cGST HsxXG014279 1 A01 pANT7_cGST 636795 HsxXG014279 2 B01 1829 AL BC034023.1 pANT7_cGST 636798 HsxXG014279 3 C01 716 CD63 BC002349.1 pANT7_cGST 636799 HsxXG014279 4 D01 785 PCNA BC000491.1 pANT7_cGST 636800 HsxXG014279 5 E01 857 SULT2A BC020755.1 pANT7_cGST 636801 HsxXG014279 6 F01 953 GNB2L1 BC000366.1 pANT7_cGST 636803 HsxXG014279 7 G01 1079 BC000439.1 pANT7_cGST 636809 HsxXG014279 8 H01 425 ATP5G BC020826.2 pANT7_cGST 636810 HsxXG014279 9 A02 596 BC000370.1 pANT7_cGST 636811 HsxXG014279 10 B02 668 GSTA BC020619.1 pANT7_cGST 636814 HsxXG014279 11 C02 878 HNM BC020677.1 pANT7_cGST 636815 HsxXG014279 12 D02 971 AKR1C BC020744.1 pANT7_cGST 636816 HsxXG014279 13 E02 1085 EBI BC020752.1 pANT7_cGST 636817 HsxXG014279 14 F02 1202 BLZF BC020716.1 pANT7_cGST 636819 HsxXG014279 15 G02 1616 BC002374.1 pANT7_cGST 636821 HsxXG014279 16 H02 254 NDUFA BC022369.1 pANT7_cGST 636823 HsxXG014279 17 A03 605 RBP BC020633.1 pANT7_cGST 636827 HsxXG014279 18 B03 881 BC000305.1 pANT7_cGST 636828 HsxXG014279 19 C03 977 EIF3S2 BC000413.1 pANT7_cGST 636834 HsxXG014279 20 D03 1646 BC000365.1 pANT7_cGST 636836 HsxXG014279 21 E03 2720 CTNNA1 BC000385.1 pANT7_cGST 636837 HsxXG014279 22 F03 329 BC000287.1 pANT7_cGST 636840 HsxXG014279 23 G03 821 OLR BC022295.1 pANT7_cGST 636841 HsxXG014279 24 H03 899 PXF BC000496.1 pANT7_cGST 636846 HsxXG014279 25 A04 1391 RUVBL2 BC000428.1 pANT7_cGST

Camacho-Encina M, et al. Ann Rheum Dis 2019; 0:1699ÿý1705. doi: 10.1136/annrheumdis-2019-215325 Supplementary material Ann Rheum Dis

636850 HsxXG014279 26 B04 356 BC000486.1 pANT7_cGST 636851 HsxXG014279 27 C04 476 BC000427.1 pANT7_cGST 636852 HsxXG014279 28 D04 707 RGS1 BC020632.1 pANT7_cGST 636854 HsxXG014279 29 E04 827 POLR2C BC000409.1 pANT7_cGST 636855 HsxXG014279 30 F04 944 HADHSC BC000306.1 pANT7_cGST 636859 HsxXG014279 31 G04 1448 C3AR BC020742.1 pANT7_cGST 636861 HsxXG014279 32 H04 1796 BC001347.1 pANT7_cGST 636862 HsxXG014279 33 A05 2147 SCI BC021090.1 pANT7_cGST 636865 HsxXG014279 34 B05 548 TNNI BC032148.2 pANT7_cGST 636868 HsxXG014279 35 C05 752 IFI3 BC021136.1 pANT7_cGST 636871 HsxXG014279 36 D05 986 CD20 BC022278.1 pANT7_cGST 636874 HsxXG014279 37 E05 1463 SLC7A BC017962.1 pANT7_cGST 636875 HsxXG014279 38 F05 1628 SLC22A BC022387.1 pANT7_cGST 636878 HsxXG014279 39 G05 386 SH2D1 BC020732.1 pANT7_cGST 636882 HsxXG014279 40 H05 818 CH25 BC017843.1 pANT7_cGST 636883 HsxXG014279 41 A06 932 AU BC020722.1 pANT7_cGST 636884 HsxXG014279 42 B06 1010 F BC017817.1 pANT7_cGST 636885 HsxXG014279 43 C06 1076 GENX-341 BC022301.1 pANT7_cGST 636886 HsxXG014279 44 D06 1172 CASQ BC022289.1 pANT7_cGST 636890 HsxXG014279 45 E06 671 UCHL1 BC000332.1 pANT7_cGST 636891 HsxXG014279 46 F06 704 TREM BC017773.1 pANT7_cGST 636894 HsxXG014279 47 G06 950 BC020823.1 pANT7_cGST 636895 HsxXG014279 48 H06 1025 POR1 BC000392.1 pANT7_cGST 636898 HsxXG014279 49 A07 1538 CYP4B BC017758.1 pANT7_cGST 636900 HsxXG014279 50 B07 1967 FGD BC023645.2 pANT7_cGST 636902 HsxXG014279 51 C07 287 CCL2 BC020698.1 pANT7_cGST 636906 HsxXG014279 52 D07 968 ARG BC020653.1 pANT7_cGST 636909 HsxXG014279 53 E07 1250 ALG BC017876.1 pANT7_cGST 636911 HsxXG014279 54 F07 1583 RAG BC022397.1 pANT7_cGST 636912 HsxXG014279 55 G07 1787 NF BC020257.1 pANT7_cGST 636915 HsxXG014279 56 H07 293 CCL1 BC017850.1 pANT7_cGST 636918 HsxXG014279 57 A08 794 PSMB4 BC000331.1 pANT7_cGST 636920 HsxXG014279 58 B08 968 XLKD BC026231.1 pANT7_cGST 636921 HsxXG014279 59 C08 1040 TFB1 BC017788.1 pANT7_cGST 636926 HsxXG014279 60 D08 1793 C4BP BC022312.1 pANT7_cGST 636927 HsxXG014279 61 E08 2057 SLC3A BC022386.1 pANT7_cGST 636933 HsxXG014279 62 F08 884 NPM1 BC002398.1 pANT7_cGST 636938 HsxXG014279 63 G08 2132 DNM1 BC024590.1 pANT7_cGST

Camacho-Encina M, et al. Ann Rheum Dis 2019; 0:1699ÿý1705. doi: 10.1136/annrheumdis-2019-215325 Supplementary material Ann Rheum Dis

637570 HsxXG014279 64 H08 1082 IL8R BC037961.1 pANT7_cGST 637571 HsxXG014279 65 A09 1253 GI BC037958.1 pANT7_cGST 637575 HsxXG014279 66 B09 1577 BC028740.1 pANT7_cGST 637577 HsxXG014279 67 C09 1943 PDE4 BC038234.1 pANT7_cGST 637582 HsxXG014279 68 D09 539 UBE2C BC016292.1 pANT7_cGST 637583 HsxXG014279 69 E09 656 RRAS BC016286.1 pANT7_cGST 637585 HsxXG014279 70 F09 956 ADORA BC029831.1 pANT7_cGST 637590 HsxXG014279 71 G09 1598 FMO BC032016.1 pANT7_cGST 637591 HsxXG014279 72 H09 1799 PTGS BC029840.1 pANT7_cGST 637603 HsxXG014279 73 A10 1532 PIAS BC029874.1 pANT7_cGST 637605 HsxXG014279 74 B10 2309 BC030016.1 pANT7_cGST 637606 HsxXG014279 75 C10 2735 BC037491.1 pANT7_cGST 637608 HsxXG014279 76 D10 662 APG10 BC029268.1 pANT7_cGST 637616 HsxXG014279 77 E10 2090 BC032848.1 pANT7_cGST 637625 HsxXG014279 78 F10 1349 TUBA6 BC004949.1 pANT7_cGST 637628 HsxXG014279 79 G10 2318 TCEB3 BC002883.1 pANT7_cGST 637629 HsxXG014279 80 H10 227 MDS02 BC019303.1 pANT7_cGST 637634 HsxXG014279 81 A11 908 SDR1 BC002730.1 pANT7_cGST 637635 HsxXG014279 82 B11 1007 PLAUR BC002788.1 pANT7_cGST 637636 HsxXG014279 83 C11 1079 TMOD BC002660.1 pANT7_cGST 637641 HsxXG014279 84 D11 1685 ASNS BC008723.1 pANT7_cGST 637642 HsxXG014279 85 E11 2378 RRM1 BC006498.1 pANT7_cGST 637645 HsxXG014279 86 F11 491 PIN1 BC002899.1 pANT7_cGST 637646 HsxXG014279 87 G11 596 AICDA BC006296.1 pANT7_cGST 637647 HsxXG014279 88 H11 767 TNFRSF9 BC006196.1 pANT7_cGST 637648 HsxXG014279 89 A12 980 DOK4 BC003541.1 pANT7_cGST 637650 HsxXG014279 90 B12 1097 SH3GLB1 BC007455.1 pANT7_cGST 637652 HsxXG014279 91 C12 1244 C4S-2 BC002918.1 pANT7_cGST 637655 HsxXG014279 92 D12 1574 PSAP BC004275.1 pANT7_cGST 637660 HsxXG014279 93 E12 527 FTL BC004245.1 pANT7_cGST 637661 HsxXG014279 94 F12 668 GSTA2 BC002895.1 pANT7_cGST 636940 HsxXG014279 95 G12 983 B4GALT7 BC007317.1 pANT7_cGST HsxXG014279 96 H12 pANT7_cGST HsxXG014280 1 A01 pANT7_cGST 636941 HsxXG014280 2 B01 1043 JUNB BC004250.1 pANT7_cGST 636943 HsxXG014280 3 C01 1172 NORE1 BC004270.1 pANT7_cGST 636944 HsxXG014280 4 D01 1319 PSMC3 BC008713.1 pANT7_cGST 636945 HsxXG014280 5 E01 1397 MKNK1 BC002755.1 pANT7_cGST

Camacho-Encina M, et al. Ann Rheum Dis 2019; 0:1699ÿý1705. doi: 10.1136/annrheumdis-2019-215325 Supplementary material Ann Rheum Dis

636949 HsxXG014280 6 F01 440 BC004324.1 pANT7_cGST 636953 HsxXG014280 7 G01 1049 WNT7A BC008811.1 pANT7_cGST 636958 HsxXG014280 8 H01 2174 HSPCB BC004928.1 pANT7_cGST 636962 HsxXG014280 9 A02 722 IGFBP6 BC003507.1 pANT7_cGST 636963 HsxXG014280 10 B02 893 ERCC1 BC008930.1 pANT7_cGST 636965 HsxXG014280 11 C02 1052 CSNK2A2 BC008812.1 pANT7_cGST 636966 HsxXG014280 12 D02 1118 GPR9 BC033571.2 pANT7_cGST 636967 HsxXG014280 13 E02 1205 TITF1 BC006221.1 pANT7_cGST 636973 HsxXG014280 14 F02 2234 BC002931.1 pANT7_cGST 636975 HsxXG014280 15 G02 446 GRP BC004488.1 pANT7_cGST 636976 HsxXG014280 16 H02 584 RPS7 BC002866.1 pANT7_cGST 636977 HsxXG014280 17 A03 905 SLC25A15 BC002702.1 pANT7_cGST 636979 HsxXG014280 18 B03 1079 SCAP2 BC002893.1 pANT7_cGST 636980 HsxXG014280 19 C03 1295 TFAP2 BC017754.1 pANT7_cGST 636981 HsxXG014280 20 D03 1517 SNTA BC026215.2 pANT7_cGST 636987 HsxXG014280 21 E03 422 PFN1 BC006768.1 pANT7_cGST 636989 HsxXG014280 22 F03 623 TIMP1 BC000866.1 pANT7_cGST 636990 HsxXG014280 23 G03 674 FKBP3 BC016288.1 pANT7_cGST 636995 HsxXG014280 24 H03 1298 KRT17 BC000159.2 pANT7_cGST 636996 HsxXG014280 25 A04 1475 KCNS3 BC015947.1 pANT7_cGST 637002 HsxXG014280 26 B04 551 FTH1 BC000857.1 pANT7_cGST 637003 HsxXG014280 27 C04 632 ARHD BC001338.1 pANT7_cGST 637005 HsxXG014280 28 D04 848 RAD1 BC006837.1 pANT7_cGST 637008 HsxXG014280 29 E04 1313 EEF1G BC015813.1 pANT7_cGST 637010 HsxXG014280 30 F04 1589 FBXW1 BC026213.1 pANT7_cGST 637011 HsxXG014280 31 G04 1940 HSPA8 BC016179.1 pANT7_cGST 637012 HsxXG014280 32 H04 2381 PTPR BC027308.1 pANT7_cGST 637013 HsxXG014280 33 A05 3476 NRIP BC040361.1 pANT7_cGST 637014 HsxXG014280 34 B05 341 TYROBP BC011175.1 pANT7_cGST 637015 HsxXG014280 35 C05 440 MCFD BC040357.2 pANT7_cGST 637016 HsxXG014280 36 D05 635 RAB38 BC015808.1 pANT7_cGST 637017 HsxXG014280 37 E05 746 HSPC154 BC000892.1 pANT7_cGST 637019 HsxXG014280 38 F05 1022 SIAT4 BC018357.1 pANT7_cGST 637020 HsxXG014280 39 G05 1097 CXADR BC003684.1 pANT7_cGST 637022 HsxXG014280 40 H05 1484 UGD BC022781.1 pANT7_cGST 637023 HsxXG014280 41 A06 1598 SLC1A BC026216.1 pANT7_cGST 637028 HsxXG014280 42 B06 914 CRK BC008506.1 pANT7_cGST 637030 HsxXG014280 43 C06 1118 CDK9 BC001968.1 pANT7_cGST

Camacho-Encina M, et al. Ann Rheum Dis 2019; 0:1699ÿý1705. doi: 10.1136/annrheumdis-2019-215325 Supplementary material Ann Rheum Dis

637032 HsxXG014280 44 D06 1412 GYG BC023152.1 pANT7_cGST 643065 HsxXG014280 45 E06 2543 MATR3 BC015031.1 pANT7_cGST 643085 HsxXG014280 46 F06 1172 TSG101 BC002487.1 pANT7_cGST 643089 HsxXG014280 47 G06 1631 BC014445.1 pANT7_cGST 643093 HsxXG014280 48 H06 464 BC014547.1 pANT7_cGST 643109 HsxXG014280 49 A07 767 SNRPA BC022816.1 pANT7_cGST 643110 HsxXG014280 50 B07 881 BC014991.1 pANT7_cGST 643118 HsxXG014280 51 C07 296 BC010954.1 pANT7_cGST 643121 HsxXG014280 52 D07 563 BC012600.1 pANT7_cGST 643125 HsxXG014280 53 E07 1037 OGG1 BC000657.1 pANT7_cGST 643131 HsxXG014280 54 F07 1682 CDC BC025232.1 pANT7_cGST 643133 HsxXG014280 55 G07 2282 TFRC BC001188.1 pANT7_cGST 643139 HsxXG014280 56 H07 794 NNMT BC000234.1 pANT7_cGST 643141 HsxXG014280 57 A08 1064 GNAT2 BC000233.1 pANT7_cGST 643158 HsxXG014280 58 B08 503 BC012628.1 pANT7_cGST 643161 HsxXG014280 59 C08 965 ANXA4 BC000182.1 pANT7_cGST 643163 HsxXG014280 60 D08 1736 IL10R BC028082.1 pANT7_cGST 643173 HsxXG014280 61 E08 1067 CX3CR BC028078.1 pANT7_cGST 643182 HsxXG014280 62 F08 2474 GCP3 BC013781.1 pANT7_cGST 643188 HsxXG014280 63 G08 1070 HNK-1ST BC010441.1 pANT7_cGST 643189 HsxXG014280 64 H08 1187 MAT1A BC018359.1 pANT7_cGST 643190 HsxXG014280 65 A09 1379 CHN1 BC011393.1 pANT7_cGST 643193 HsxXG014280 66 B09 1760 GGTLA1 BC011362.1 pANT7_cGST 643199 HsxXG014280 67 C09 752 HLA-DOA BC013183.1 pANT7_cGST 643203 HsxXG014280 68 D09 1388 GABRA5 BC011403.1 pANT7_cGST 643204 HsxXG014280 69 E09 1457 AGT BC011519.1 pANT7_cGST 643210 HsxXG014280 70 F09 635 BC015244.1 pANT7_cGST 643211 HsxXG014280 71 G09 881 SC4MOL BC010653.1 pANT7_cGST 643216 HsxXG014280 72 H09 2039 SLC20A1 BC019944.1 pANT7_cGST 643218 HsxXG014280 73 A10 2771 HK BC028129.1 pANT7_cGST 643219 HsxXG014280 74 B10 3470 NUP133 BC020107.1 pANT7_cGST 643220 HsxXG014280 75 C10 353 GHR BC025791.1 pANT7_cGST 643222 HsxXG014280 76 D10 650 STMN4 BC011520.1 pANT7_cGST 643223 HsxXG014280 77 E10 776 HLA-DPB1 BC013184.1 pANT7_cGST 643226 HsxXG014280 78 F10 1334 KIR3DL BC028206.1 pANT7_cGST 643230 HsxXG014280 79 G10 2396 ITGB1 BC020057.1 pANT7_cGST 643233 HsxXG014280 80 H10 386 PPB BC028217.1 pANT7_cGST 643234 HsxXG014280 81 A11 548 CBFB BC018509.1 pANT7_cGST

Camacho-Encina M, et al. Ann Rheum Dis 2019; 0:1699ÿý1705. doi: 10.1136/annrheumdis-2019-215325 Supplementary material Ann Rheum Dis

643240 HsxXG014280 82 B11 2252 ARHGAP9 BC006107.1 pANT7_cGST 643244 HsxXG014280 83 C11 578 BC009605.1 pANT7_cGST 643246 HsxXG014280 84 D11 923 SLC25A17 BC005957.1 pANT7_cGST 643248 HsxXG014280 85 E11 1067 SIRT6 BC005026.1 pANT7_cGST 643254 HsxXG014280 86 F11 374 MAP2K1IP BC026245.1 pANT7_cGST 643272 HsxXG014280 87 G11 830 OIP BC020773.1 pANT7_cGST 643282 HsxXG014280 88 H11 230 HSPC132 BC002638.1 pANT7_cGST 643283 HsxXG014280 89 A12 353 GABARAPL2 BC005985.1 pANT7_cGST 643284 HsxXG014280 90 B12 443 UBE2D1 BC005980.1 pANT7_cGST 643288 HsxXG014280 91 C12 1121 AMID BC006121.1 pANT7_cGST 643309 HsxXG014280 92 D12 281 S100A8 BC005928.1 pANT7_cGST 643310 HsxXG014280 93 E12 362 EIF4EBP2 BC005057.1 pANT7_cGST 643316 HsxXG014280 94 F12 1298 AHCY BC011606.1 pANT7_cGST 643317 HsxXG014280 95 G12 1382 BC014962.1 pANT7_cGST HsxXG014280 96 H12 pANT7_cGST HsxXG014281 1 A01 pANT7_cGST 643329 HsxXG014281 2 B01 1322 PSMC1 BC000512.1 pANT7_cGST 643330 HsxXG014281 3 C01 1382 BC012125.1 pANT7_cGST 658410 HsxXG014281 4 D01 1085 BC014455.1 pANT7_cGST 658411 HsxXG014281 5 E01 1127 PISD BC001482.1 pANT7_cGST 658418 HsxXG014281 6 F01 2396 BC015916.1 pANT7_cGST 658468 HsxXG014281 7 G01 2468 ANAPC BC032503.1 pANT7_cGST 658471 HsxXG014281 8 H01 902 SURF BC028314.1 pANT7_cGST 658491 HsxXG014281 9 A02 2012 BC034959.1 pANT7_cGST 643532 HsxXG014281 10 B02 1034 CCNG BC032518.1 pANT7_cGST 643534 HsxXG014281 11 C02 1226 BC036373.1 pANT7_cGST 643535 HsxXG014281 12 D02 1292 ACAD BC039063.1 pANT7_cGST 643538 HsxXG014281 13 E02 1655 SLC22A BC028313.1 pANT7_cGST 643544 HsxXG014281 14 F02 875 ATP4 BC029059.1 pANT7_cGST 643546 HsxXG014281 15 G02 1037 TOB BC031406.1 pANT7_cGST 643548 HsxXG014281 16 H02 1238 DOK BC032623.1 pANT7_cGST 643552 HsxXG014281 17 A03 1898 LN BC034737.1 pANT7_cGST 643578 HsxXG014281 18 B03 1988 ABCG BC029158.1 pANT7_cGST 643580 HsxXG014281 19 C03 305 S100A BC034687.1 pANT7_cGST 643586 HsxXG014281 20 D03 1064 SYN47 BC015502.1 pANT7_cGST 643596 HsxXG014281 21 E03 836 FBG4 BC012385.1 pANT7_cGST 643599 HsxXG014281 22 F03 1196 EDG BC034703.1 pANT7_cGST 643600 HsxXG014281 23 G03 1274 ACAA1 BC011977.1 pANT7_cGST

Camacho-Encina M, et al. Ann Rheum Dis 2019; 0:1699ÿý1705. doi: 10.1136/annrheumdis-2019-215325 Supplementary material Ann Rheum Dis

643606 HsxXG014281 24 H03 461 UBE2L BC032491.1 pANT7_cGST 643614 HsxXG014281 25 A04 1514 SHMT2 BC013677.1 pANT7_cGST 643619 HsxXG014281 26 B04 467 ID1 BC012420.1 pANT7_cGST 643629 HsxXG014281 27 C04 1673 IFNAR BC021825.1 pANT7_cGST 643631 HsxXG014281 28 D04 404 CYB5 BC015182.1 pANT7_cGST 643633 HsxXG014281 29 E04 680 MGC3513 BC029895.1 pANT7_cGST 643634 HsxXG014281 30 F04 800 GJB BC034709.1 pANT7_cGST 643635 HsxXG014281 31 G04 992 GPBAR BC033625.1 pANT7_cGST 643638 HsxXG014281 32 H04 1421 BC011787.1 pANT7_cGST 643644 HsxXG014281 33 A05 671 SR-BP1 BC004899.1 pANT7_cGST 643645 HsxXG014281 34 B05 824 NQO1 BC007659.1 pANT7_cGST 643649 HsxXG014281 35 C05 1232 BC011685.1 pANT7_cGST 643651 HsxXG014281 36 D05 1430 TRIP6 BC004999.1 pANT7_cGST 643652 HsxXG014281 37 E05 1529 BC014210.1 pANT7_cGST 643660 HsxXG014281 38 F05 986 BC011792.1 pANT7_cGST 643663 HsxXG014281 39 G05 1247 BC012609.1 pANT7_cGST 643664 HsxXG014281 40 H05 1373 BC011780.1 pANT7_cGST 643666 HsxXG014281 41 A06 1574 CDC25A BC007401.1 pANT7_cGST 643667 HsxXG014281 42 B06 1730 BC010385.1 pANT7_cGST 643668 HsxXG014281 43 C06 1952 FAF1 BC004970.1 pANT7_cGST 643672 HsxXG014281 44 D06 854 BC011776.1 pANT7_cGST 643673 HsxXG014281 45 E06 950 BC012588.1 pANT7_cGST 643676 HsxXG014281 46 F06 1157 PELO BC005889.1 pANT7_cGST 643678 HsxXG014281 47 G06 1382 BC013316.1 pANT7_cGST 643679 HsxXG014281 48 H06 1433 BC019043.1 pANT7_cGST 643690 HsxXG014281 49 A07 1307 AP2M1 BC004996.1 pANT7_cGST 643694 HsxXG014281 50 B07 500 CDKN2D BC001822.1 pANT7_cGST 643696 HsxXG014281 51 C07 731 RPS3 BC003137.1 pANT7_cGST 643698 HsxXG014281 52 D07 1127 BC010927.1 pANT7_cGST 643700 HsxXG014281 53 E07 1262 GMPPA BC007456.1 pANT7_cGST 643701 HsxXG014281 54 F07 1472 BC010398.1 pANT7_cGST 643707 HsxXG014281 55 G07 758 BC009799.1 pANT7_cGST 643713 HsxXG014281 56 H07 1664 BC035055.1 pANT7_cGST 658309 HsxXG014281 57 A08 998 SLC25A1 BC030266.1 pANT7_cGST 658332 HsxXG014281 58 B08 701 TN BC028148.1 pANT7_cGST 658345 HsxXG014281 59 C08 413 BC022069.1 pANT7_cGST 658354 HsxXG014281 60 D08 2207 BC031870.1 pANT7_cGST 658359 HsxXG014281 61 E08 707 DLX BC036189.1 pANT7_cGST

Camacho-Encina M, et al. Ann Rheum Dis 2019; 0:1699ÿý1705. doi: 10.1136/annrheumdis-2019-215325 Supplementary material Ann Rheum Dis

658363 HsxXG014281 62 F08 1409 BC026104.1 pANT7_cGST 658364 HsxXG014281 63 G08 1529 CYP4X BC028102.1 pANT7_cGST 658369 HsxXG014281 64 H08 452 BC024240.1 pANT7_cGST 658375 HsxXG014281 65 A09 1142 IL13RA BC033705.2 pANT7_cGST 658376 HsxXG014281 66 B09 1199 MTERF BC000965.2 pANT7_cGST 658379 HsxXG014281 67 C09 428 FKBP2 BC003384.1 pANT7_cGST 658383 HsxXG014281 68 D09 848 SIAH BC035562.1 pANT7_cGST 658392 HsxXG014281 69 E09 2540 BC036013.1 pANT7_cGST 658393 HsxXG014281 70 F09 437 PTS BC009686.1 pANT7_cGST 658399 HsxXG014281 71 G09 1019 ANXA2 BC009564.1 pANT7_cGST 643719 HsxXG014281 72 H09 2237 ABCD1 BC015541.1 pANT7_cGST 643722 HsxXG014281 73 A10 623 CLDN11 BC013577.1 pANT7_cGST 643732 HsxXG014281 74 B10 2255 EZH2 BC010858.1 pANT7_cGST 643735 HsxXG014281 75 C10 455 RPS14 BC003401.1 pANT7_cGST 643736 HsxXG014281 76 D10 638 EDN1 BC009720.1 pANT7_cGST 643738 HsxXG014281 77 E10 887 SULT1A1 BC000923.2 pANT7_cGST 643741 HsxXG014281 78 F10 1112 PSA BC000971.1 pANT7_cGST 643748 HsxXG014281 79 G10 461 BC036072.1 pANT7_cGST 643751 HsxXG014281 80 H10 770 TIRA BC032474.1 pANT7_cGST 643752 HsxXG014281 81 A11 992 AKR7A2 BC010852.1 pANT7_cGST 643754 HsxXG014281 82 B11 1127 ACTB BC001301.1 pANT7_cGST 643755 HsxXG014281 83 C11 1193 F2RL1 BC018130.1 pANT7_cGST 643764 HsxXG014281 84 D11 1001 EIF2S2 BC000934.2 pANT7_cGST 643771 HsxXG014281 85 E11 512 PGF BC001422.1 pANT7_cGST 643777 HsxXG014281 86 F11 1301 HRMT1L1 BC000727.1 pANT7_cGST 643778 HsxXG014281 87 G11 1388 MIG- BC025337.1 pANT7_cGST 643784 HsxXG014281 88 H11 1040 XRCC3 BC001036.1 pANT7_cGST 643788 HsxXG014281 89 A12 1412 ATP6IP1 BC000724.1 pANT7_cGST 643794 HsxXG014281 90 B12 785 BC017310.1 pANT7_cGST 643795 HsxXG014281 91 C12 971 PPP2R4 BC002545.1 pANT7_cGST 643796 HsxXG014281 92 D12 1046 CAPG BC000728.1 pANT7_cGST 643797 HsxXG014281 93 E12 1136 CDC37 BC000083.1 pANT7_cGST 643800 HsxXG014281 94 F12 1610 GRB1 BC024285.1 pANT7_cGST 643810 HsxXG014281 95 G12 1238 ACAD BC025963.1 pANT7_cGST HsxXG014281 96 H12 pANT7_cGST HsxXG014282 1 A01 pANT7_cGST 643815 HsxXG014282 2 B01 2048 GFPT2 BC000012.1 pANT7_cGST 643820 HsxXG014282 3 C01 875 IGFBP3 BC000013.1 pANT7_cGST

Camacho-Encina M, et al. Ann Rheum Dis 2019; 0:1699ÿý1705. doi: 10.1136/annrheumdis-2019-215325 Supplementary material Ann Rheum Dis

643838 HsxXG014282 4 D01 1307 CASP2 BC002427.1 pANT7_cGST 643845 HsxXG014282 5 E01 239 COX7A1 BC002757.1 pANT7_cGST 643847 HsxXG014282 6 F01 668 GSTA4 BC015523.1 pANT7_cGST 643848 HsxXG014282 7 G01 785 KLK2 BC005196.1 pANT7_cGST 643857 HsxXG014282 8 H01 1238 CTSD BC016320.1 pANT7_cGST 643861 HsxXG014282 9 A02 1532 ETV5 BC007333.1 pANT7_cGST 643868 HsxXG014282 10 B02 734 KLK6 BC015525.1 pANT7_cGST 643870 HsxXG014282 11 C02 977 AKR1A1 BC000670.1 pANT7_cGST 643877 HsxXG014282 12 D02 1583 MAOA BC008064.1 pANT7_cGST 643881 HsxXG014282 13 E02 536 CAV1 BC009685.1 pANT7_cGST 643883 HsxXG014282 14 F02 734 ARHE BC012513.1 pANT7_cGST 643888 HsxXG014282 15 G02 1409 ETS2 BC017040.1 pANT7_cGST 643894 HsxXG014282 16 H02 566 KRAS2 BC013572.1 pANT7_cGST 643897 HsxXG014282 17 A03 1115 ELF3 BC003569.1 pANT7_cGST 643899 HsxXG014282 18 B03 1304 ENO2 BC002745.1 pANT7_cGST 643904 HsxXG014282 19 C03 1676 FMO4 BC002780.1 pANT7_cGST 643906 HsxXG014282 20 D03 590 RGS1 BC015510.1 pANT7_cGST 643907 HsxXG014282 21 E03 656 GSTM4 BC015513.1 pANT7_cGST 643908 HsxXG014282 22 F03 971 AKR1C3 BC001479.1 pANT7_cGST 643941 HsxXG014282 23 G03 977 HMGCL BC010570.1 pANT7_cGST 643953 HsxXG014282 24 H03 794 CA BC033865.1 pANT7_cGST 643961 HsxXG014282 25 A04 2147 MX BC035293.1 pANT7_cGST 643987 HsxXG014282 26 B04 1490 CD81 BC002978.1 pANT7_cGST 644021 HsxXG014282 27 C04 2528 ABCB6 BC000559.1 pANT7_cGST 644026 HsxXG014282 28 D04 1481 ARIH2 BC000422.1 pANT7_cGST 644039 HsxXG014282 29 E04 1331 COX10 BC000060.1 pANT7_cGST 644040 HsxXG014282 30 F04 1421 PTDSS1 BC004192.1 pANT7_cGST 644052 HsxXG014282 31 G04 497 BC018048.1 pANT7_cGST 644056 HsxXG014282 32 H04 1010 BC018051.1 pANT7_cGST 644059 HsxXG014282 33 A05 1379 BC018056.1 pANT7_cGST 644062 HsxXG014282 34 B05 1856 BIRC2 BC016174.1 pANT7_cGST 644075 HsxXG014282 35 C05 569 HEBP1 BC016277.1 pANT7_cGST 644094 HsxXG014282 36 D05 1382 MOCS3 BC015939.1 pANT7_cGST 644104 HsxXG014282 37 E05 1139 BC018037.1 pANT7_cGST 644121 HsxXG014282 38 F05 359 B2 BC032589.1 pANT7_cGST 644133 HsxXG014282 39 G05 404 BC030639.1 pANT7_cGST 644140 HsxXG014282 40 H05 1565 BC034493.1 pANT7_cGST 644161 HsxXG014282 41 A06 1508 CYP2J BC032594.1 pANT7_cGST

Camacho-Encina M, et al. Ann Rheum Dis 2019; 0:1699ÿý1705. doi: 10.1136/annrheumdis-2019-215325 Supplementary material Ann Rheum Dis

644162 HsxXG014282 42 B06 1715 BC037733.1 pANT7_cGST 644168 HsxXG014282 43 C06 1049 TAF BC032737.1 pANT7_cGST 644170 HsxXG014282 44 D06 1319 BC030691.1 pANT7_cGST 644171 HsxXG014282 45 E06 1601 BC034951.1 pANT7_cGST 644178 HsxXG014282 46 F06 1058 KER BC032667.2 pANT7_cGST 644183 HsxXG014282 47 G06 299 SCYA2 BC009716.1 pANT7_cGST 644185 HsxXG014282 48 H06 755 RAB34 BC016841.1 pANT7_cGST 644188 HsxXG014282 49 A07 473 AP1S2 BC001117.1 pANT7_cGST 644193 HsxXG014282 50 B07 950 BC010391.1 pANT7_cGST 644197 HsxXG014282 51 C07 1247 BC011900.1 pANT7_cGST 644200 HsxXG014282 52 D07 1967 TNFRSF21 BC017730.1 pANT7_cGST 644204 HsxXG014282 53 E07 971 BC020216.1 pANT7_cGST 644262 HsxXG014282 54 F07 848 C1QBP BC013731.1 pANT7_cGST 644265 HsxXG014282 55 G07 1424 BC022449.1 pANT7_cGST 644272 HsxXG014282 56 H07 170 RPS2 BC032813.1 pANT7_cGST 644283 HsxXG014282 57 A08 833 BC039152.1 pANT7_cGST 644285 HsxXG014282 58 B08 1589 RE BC028163.1 pANT7_cGST 644287 HsxXG014282 59 C08 1115 F8 BC039693.1 pANT7_cGST 644289 HsxXG014282 60 D08 1448 BC032831.1 pANT7_cGST 644296 HsxXG014282 61 E08 1514 CYP2S BC033691.1 pANT7_cGST 644298 HsxXG014282 62 F08 293 BC029497.1 pANT7_cGST 644310 HsxXG014282 63 G08 527 RAMP BC027975.1 pANT7_cGST 644311 HsxXG014282 64 H08 1880 TESK BC038448.1 pANT7_cGST 644314 HsxXG014282 65 A09 1100 LEFT BC027883.1 pANT7_cGST 644316 HsxXG014282 66 B09 1175 SSTR BC035618.1 pANT7_cGST 644321 HsxXG014282 67 C09 2420 HNRPU BC003367.1 pANT7_cGST 644322 HsxXG014282 68 D09 707 CD8 BC025715.1 pANT7_cGST 644323 HsxXG014282 69 E09 2174 COM BC033676.1 pANT7_cGST 644325 HsxXG014282 70 F09 974 NKX2- BC025711.1 pANT7_cGST 644332 HsxXG014282 71 G09 560 NDUFB8 BC000466.1 pANT7_cGST 656662 HsxXG014282 72 H09 623 IL24 BC009681.1 pANT7_cGST 656668 HsxXG014282 73 A10 1463 BC022009.1 pANT7_cGST 656671 HsxXG014282 74 B10 1388 CYP20A BC033752.1 pANT7_cGST 656676 HsxXG014282 75 C10 1661 ATP5A1 NM_004046 pANT7_cGST 656679 HsxXG014282 76 D10 1118 CDK9 NM_001261 pANT7_cGST 656681 HsxXG014282 77 E10 617 HSPB BC073768.1 pANT7_cGST 656682 HsxXG014282 78 F10 782 CA2 NM_000067 pANT7_cGST 656684 HsxXG014282 79 G10 1034 MTHFD BC001548.1 pANT7_cGST

Camacho-Encina M, et al. Ann Rheum Dis 2019; 0:1699ÿý1705. doi: 10.1136/annrheumdis-2019-215325 Supplementary material Ann Rheum Dis

656691 HsxXG014282 80 H10 1736 GALNT4 BC036390 pANT7_cGST 656694 HsxXG014282 81 A11 500 TXN2 BC050610 pANT7_cGST 656697 HsxXG014282 82 B11 1172 PDHA1 BC002406.1 pANT7_cGST 656699 HsxXG014282 83 C11 485 THY1 NM_006288 pANT7_cGST 656702 HsxXG014282 84 D11 1181 HOXA10 BC013971 pANT7_cGST 656706 HsxXG014282 85 E11 1343 GDI1 BC012201.1 pANT7_cGST 656707 HsxXG014282 86 F11 1376 CPN BC027897.1 pANT7_cGST 656708 HsxXG014282 87 G11 770 CSEN BC012850.1 pANT7_cGST 656713 HsxXG014282 88 H11 311 LSM BC018621.1 pANT7_cGST 656714 HsxXG014282 89 A12 359 ID3 BC003107.1 pANT7_cGST 656720 HsxXG014282 90 B12 1157 IDH3B NM_006899 pANT7_cGST 656721 HsxXG014282 91 C12 1211 PTEN BC005821 pANT7_cGST 656723 HsxXG014282 92 D12 611 RAB30 BC014213 pANT7_cGST 656725 HsxXG014282 93 E12 1505 PWP1 BC001652 pANT7_cGST 656731 HsxXG014282 94 F12 935 SLC25A1 BC004980.1 pANT7_cGST 656740 HsxXG014282 95 G12 1298 SLC35B2 NM_178148 pANT7_cGST HsxXG014282 96 H12 pANT7_cGST HsxXG014283 1 A01 pANT7_cGST 656744 HsxXG014283 2 B01 1424 GABRB1 NM_000812 pANT7_cGST 656749 HsxXG014283 3 C01 467 ID1 BC000613 pANT7_cGST 656751 HsxXG014283 4 D01 743 PEX11A NM_003847 pANT7_cGST 640781 HsxXG014283 5 E01 1001 BAPX BC111966.1 pANT7_cGST 640782 HsxXG014283 6 F01 1004 BC011868.1 pANT7_cGST 640795 HsxXG014283 7 G01 1556 TBX BC027942.1 pANT7_cGST 640802 HsxXG014283 8 H01 1241 ZNF55 BC053858.1 pANT7_cGST 640808 HsxXG014283 9 A02 356 TCEB2 BC013306.1 pANT7_cGST 640813 HsxXG014283 10 B02 644 NEUROG BC074939.2 pANT7_cGST 640818 HsxXG014283 11 C02 1958 KIAA0798 BC002858.1 pANT7_cGST 640819 HsxXG014283 12 D02 2021 ZNF14 BC026902.1 pANT7_cGST 640821 HsxXG014283 13 E02 1031 HRMT1L2 BC019268.1 pANT7_cGST 640822 HsxXG014283 14 F02 1208 ZNF55 BC064356.1 pANT7_cGST 640823 HsxXG014283 15 G02 581 AF093680 BC005152.1 pANT7_cGST 640829 HsxXG014283 16 H02 1436 MGC4400 BC004992.1 pANT7_cGST 640830 HsxXG014283 17 A03 647 HAND1 BC021190.1 pANT7_cGST 640832 HsxXG014283 18 B03 1622 BC011826.1 pANT7_cGST 640836 HsxXG014283 19 C03 1895 TCF BC104910.1 pANT7_cGST 640837 HsxXG014283 20 D03 1058 SIRT2 BC003012.1 pANT7_cGST 640842 HsxXG014283 21 E03 1259 BRF2 BC010648.1 pANT7_cGST

Camacho-Encina M, et al. Ann Rheum Dis 2019; 0:1699ÿý1705. doi: 10.1136/annrheumdis-2019-215325 Supplementary material Ann Rheum Dis

640843 HsxXG014283 22 F03 332 PHF5A BC007321.1 pANT7_cGST 640859 HsxXG014283 23 G03 602 HIP BC050600.1 pANT7_cGST 640862 HsxXG014283 24 H03 1502 PLAG BC075048.2 pANT7_cGST 640864 HsxXG014283 25 A04 1520 ZNF15 BC075003.2 pANT7_cGST 640865 HsxXG014283 26 B04 752 KCNIP BC032520.1 pANT7_cGST 659035 HsxXG014283 27 C04 1616 ZNF15 BC075050.2 pANT7_cGST 659037 HsxXG014283 28 D04 821 NKX2- BC075092.2 pANT7_cGST 659045 HsxXG014283 29 E04 953 RNF4 BC032637.1 pANT7_cGST 659049 HsxXG014283 30 F04 1790 LZTS BC075007.2 pANT7_cGST 659058 HsxXG014283 31 G04 1121 RASSF BC106921.1 pANT7_cGST 659059 HsxXG014283 32 H04 1886 ZNF52 BC111950.1 pANT7_cGST 659063 HsxXG014283 33 A05 1220 LHX BC111936.1 pANT7_cGST 659064 HsxXG014283 34 B05 1937 ZNF57 BC042170.2 pANT7_cGST 659067 HsxXG014283 35 C05 2048 ZNF4 BC037575.1 pANT7_cGST 659069 HsxXG014283 36 D05 1280 ZNF56 BC109062.1 pANT7_cGST 659071 HsxXG014283 37 E05 1283 VD BC060832.1 pANT7_cGST 659073 HsxXG014283 38 F05 2210 BACH BC063307.1 pANT7_cGST 659074 HsxXG014283 39 G05 1328 ESRR BC064700.1 pANT7_cGST 659081 HsxXG014283 40 H05 1352 PDE7 BC075082.2 pANT7_cGST 659095 HsxXG014283 41 A06 1403 PPP2R5 BC093766.1 pANT7_cGST 659097 HsxXG014283 42 B06 1403 SMAD BC104760.1 pANT7_cGST 659105 HsxXG014283 43 C06 641 ZFAND BC073131.1 pANT7_cGST 659117 HsxXG014283 44 D06 1709 ZNF58 BC111772.1 pANT7_cGST 659119 HsxXG014283 45 E06 917 NANO BC098275.1 pANT7_cGST 659121 HsxXG014283 46 F06 1754 MGC4862 BC050038.1 pANT7_cGST 658218 HsxXG014283 47 G06 1787 ZNF31 BC078154.1 pANT7_cGST 658220 HsxXG014283 48 H06 1817 ZNF354 BC047105.1 pANT7_cGST 658221 HsxXG014283 49 A07 1079 KLF BC112109.1 pANT7_cGST 658227 HsxXG014283 50 B07 1160 BC021113.1 pANT7_cGST 658231 HsxXG014283 51 C07 1220 LHX BC112185.1 pANT7_cGST 658246 HsxXG014283 52 D07 1274 FLJ3307 BC029899.1 pANT7_cGST 658250 HsxXG014283 53 E07 1298 TRIP13 BC000404.1 pANT7_cGST 658251 HsxXG014283 54 F07 1301 BC002589.1 pANT7_cGST 658257 HsxXG014283 55 G07 575 CBX5 BC006821.1 pANT7_cGST 658263 HsxXG014283 56 H07 1535 LOC9161 BC030970.1 pANT7_cGST 658272 HsxXG014283 57 A08 815 ATF BC029619.1 pANT7_cGST 658278 HsxXG014283 58 B08 1847 CBFA2T BC062624.1 pANT7_cGST 658279 HsxXG014283 59 C08 926 GTF2H BC065250.1 pANT7_cGST

Camacho-Encina M, et al. Ann Rheum Dis 2019; 0:1699ÿý1705. doi: 10.1136/annrheumdis-2019-215325 Supplementary material Ann Rheum Dis

658280 HsxXG014283 60 D08 953 SOX2 BC013923.1 pANT7_cGST 658282 HsxXG014283 61 E08 1910 ZNF51 BC036676.1 pANT7_cGST 658287 HsxXG014283 62 F08 2120 TCF1 BC050556.1 pANT7_cGST 658297 HsxXG014283 63 G08 1199 LEF BC050632.2 pANT7_cGST 659222 HsxXG014283 64 H08 683 GAS41 BC000994.2 pANT7_cGST 659225 HsxXG014283 65 A09 806 SNAI2 BC015895.1 pANT7_cGST 659230 HsxXG014283 66 B09 854 LOC51058 BC000157.2 pANT7_cGST 659243 HsxXG014283 67 C09 2042 BHC80 BC015714.1 pANT7_cGST 659246 HsxXG014283 68 D09 2255 ZNF18 BC022992.1 pANT7_cGST 659251 HsxXG014283 69 E09 311 LOC115648 BC006408.1 pANT7_cGST 659254 HsxXG014283 70 F09 1256 ZNF56 BC104888.1 pANT7_cGST 659262 HsxXG014283 71 G09 1358 ETV BC043399.1 pANT7_cGST 659269 HsxXG014283 72 H09 734 KLF BC069431.1 pANT7_cGST 659275 HsxXG014283 73 A10 1568 ZNF45 BC105061.1 pANT7_cGST 659292 HsxXG014283 74 B10 380 HIST1H2B BC093759.1 pANT7_cGST 659298 HsxXG014283 75 C10 668 LOC51652 BC004419.1 pANT7_cGST 659305 HsxXG014283 76 D10 1568 NRF1 BC016925.1 pANT7_cGST 659122 HsxXG014283 77 E10 1601 BC030788.1 pANT7_cGST 659125 HsxXG014283 78 F10 1706 BC003183.1 pANT7_cGST 659131 HsxXG014283 79 G10 1775 EB BC038805.1 pANT7_cGST 659134 HsxXG014283 80 H10 1304 TEAD4 BC015497.1 pANT7_cGST 659138 HsxXG014283 81 A11 1136 ZNF68 BC091518.1 pANT7_cGST 659139 HsxXG014283 82 B11 1157 MTERFD BC036066.1 pANT7_cGST 659143 HsxXG014283 83 C11 1271 ESRR BC093722.1 pANT7_cGST 659145 HsxXG014283 84 D11 1310 ORC4 BC014847.1 pANT7_cGST 659146 HsxXG014283 85 E11 2312 BC014482.1 pANT7_cGST 659148 HsxXG014283 86 F11 2333 BC015610.1 pANT7_cGST 659149 HsxXG014283 87 G11 2345 CTNNB BC058926.1 pANT7_cGST 659161 HsxXG014283 88 H11 785 ZNF66 BC101530.1 pANT7_cGST 659164 HsxXG014283 89 A12 1589 KIAA119 BC038586.1 pANT7_cGST 659171 HsxXG014283 90 B12 980 ZFP36 BC009693.1 pANT7_cGST 659172 HsxXG014283 91 C12 1649 BC036096.1 pANT7_cGST 659177 HsxXG014283 92 D12 1142 BC010032.1 pANT7_cGST 659179 HsxXG014283 93 E12 1187 AIBZI BC038962.1 pANT7_cGST 659181 HsxXG014283 94 F12 1208 ZNF54 BC042681.1 pANT7_cGST 659191 HsxXG014283 95 G12 1622 LOC16265 BC024227.1 pANT7_cGST HsxXG014283 96 H12 pANT7_cGST HsxXG014284 1 A01 pANT7_cGST

Camacho-Encina M, et al. Ann Rheum Dis 2019; 0:1699ÿý1705. doi: 10.1136/annrheumdis-2019-215325 Supplementary material Ann Rheum Dis

659193 HsxXG014284 2 B01 560 TBPL1 BC000381.1 pANT7_cGST 635728 HsxXG014284 3 C01 1859 FLJ1347 BC021997.2 pANT7_cGST 635730 HsxXG014284 4 D01 1181 ISGF3 BC035716.2 pANT7_cGST 635737 HsxXG014284 5 E01 638 USP4 BC040950.1 pANT7_cGST 635759 HsxXG014284 6 F01 1877 ARNT BC041129.1 pANT7_cGST 635761 HsxXG014284 7 G01 1967 KLHL1 BC064576.1 pANT7_cGST 635773 HsxXG014284 8 H01 1388 RXR BC110998.1 pANT7_cGST 635777 HsxXG014284 9 A02 2513 ZHX BC042145.1 pANT7_cGST 635778 HsxXG014284 10 B02 2519 BC030790.1 pANT7_cGST 635780 HsxXG014284 11 C02 2540 CLOC BC041878.1 pANT7_cGST 635783 HsxXG014284 12 D02 2615 BC018612.1 pANT7_cGST 635787 HsxXG014284 13 E02 2909 NFKB BC051765.1 pANT7_cGST 635791 HsxXG014284 14 F02 3080 LUZP BC051733.1 pANT7_cGST 635796 HsxXG014284 15 G02 1385 NR5A BC032501.1 pANT7_cGST 635806 HsxXG014284 16 H02 1406 TRIM1 BC069227.1 pANT7_cGST 635808 HsxXG014284 17 A03 1154 TCF BC072023.1 pANT7_cGST 634203 HsxXG014284 18 B03 965 OR5V1 NM_030876 pANT7_cGST 634210 HsxXG014284 19 C03 269 NPS NM_001030013 pANT7_cGST 634215 HsxXG014284 20 D03 2342 SLC26A4 NM_000441 pANT7_cGST 634224 HsxXG014284 21 E03 1238 MLNR NM_001507 pANT7_cGST 634232 HsxXG014284 22 F03 458 RGS21 NM_001039152 pANT7_cGST 634236 HsxXG014284 23 G03 212 01-Dec NM_017418 pANT7_cGST 634237 HsxXG014284 24 H03 203 DEFB111 NM_001037497 pANT7_cGST 634238 HsxXG014284 25 A04 935 OR6C3 NM_054104 pANT7_cGST 634243 HsxXG014284 26 B04 239 DEFB130 NM_001037804 pANT7_cGST 634245 HsxXG014284 27 C04 635 SOCS1 NM_003745 pANT7_cGST 634247 HsxXG014284 28 D04 1985 F13B NM_001994 pANT7_cGST 634248 HsxXG014284 29 E04 1502 ESRRB NM_004452 pANT7_cGST 634249 HsxXG014284 30 F04 3311 GUCY2D NM_000180 pANT7_cGST 634252 HsxXG014284 31 G04 647 IL19 NM_153758 pANT7_cGST 634253 HsxXG014284 32 H04 974 OR52I1 NM_001005169 pANT7_cGST 634256 HsxXG014284 33 A05 1484 CYP2A13 NM_000766 pANT7_cGST 634262 HsxXG014284 34 B05 1109 OR2T1 NM_030904 pANT7_cGST 634263 HsxXG014284 35 C05 1688 ARSH NM_001011719 pANT7_cGST 634275 HsxXG014284 36 D05 1037 OR11G2 NM_001005503 pANT7_cGST 634276 HsxXG014284 37 E05 938 OR51B6 NM_001004750 pANT7_cGST 633868 HsxXG014284 38 F05 2618 KCNQ2 NM_172107 pANT7_cGST 633882 HsxXG014284 39 G05 914 SULT1C3 NM_001008743 pANT7_cGST

Camacho-Encina M, et al. Ann Rheum Dis 2019; 0:1699ÿý1705. doi: 10.1136/annrheumdis-2019-215325 Supplementary material Ann Rheum Dis

633883 HsxXG014284 40 H05 668 GSTA5 NM_153699 pANT7_cGST 633884 HsxXG014284 41 A06 2264 RXFP2 NM_130806 pANT7_cGST 633894 HsxXG014284 42 B06 2501 MAP4K1 NM_007181 pANT7_cGST 633900 HsxXG014284 43 C06 1943 LIMK1 NM_002314 pANT7_cGST 633910 HsxXG014284 44 D06 2174 SLCO4C1 NM_180991 pANT7_cGST 633912 HsxXG014284 45 E06 2237 RPS6KA6 NM_014496 pANT7_cGST 633915 HsxXG014284 46 F06 641 EFNA2 NM_001405 pANT7_cGST 633917 HsxXG014284 47 G06 944 OR5D14 NM_001004735 pANT7_cGST 633920 HsxXG014284 48 H06 1562 CYP4F8 NM_007253 pANT7_cGST 633926 HsxXG014284 49 A07 1244 PPIL5 NM_152329 pANT7_cGST 633928 HsxXG014284 50 B07 4967 SCRIB NM_182706 pANT7_cGST 633929 HsxXG014284 51 C07 3896 TBC1D4 NM_014832 pANT7_cGST 633933 HsxXG014284 52 D07 1592 UGT1A7 NM_019077 pANT7_cGST 633942 HsxXG014284 53 E07 2072 SLC27A5 NM_012254 pANT7_cGST 633944 HsxXG014284 54 F07 1904 SLC6A19 NM_001003841 pANT7_cGST 633948 HsxXG014284 55 G07 1403 RGS11 NM_183337 pANT7_cGST 637776 HsxXG014284 56 H07 197 DEFB106A NM_152251 pANT7_cGST 637782 HsxXG014284 57 A08 887 SULT1A3 NM_177552 pANT7_cGST 637783 HsxXG014284 58 B08 1604 UGT1A5 NM_019078 pANT7_cGST 637792 HsxXG014284 59 C08 1994 SLC5A1 NM_000343 pANT7_cGST 637800 HsxXG014284 60 D08 3293 LIFR NM_002310 pANT7_cGST 637802 HsxXG014284 61 E08 941 OR4E2 NM_001001912 pANT7_cGST 637806 HsxXG014284 62 F08 341 DEFB112 NM_001037498 pANT7_cGST 637808 HsxXG014284 63 G08 3017 EPHA8 NM_020526 pANT7_cGST 637812 HsxXG014284 64 H08 1205 B3GNT7 NM_145236 pANT7_cGST 637822 HsxXG014284 65 A09 1592 UGT2B15 NM_001076 pANT7_cGST 637824 HsxXG014284 66 B09 953 OR52M1 NM_001004137 pANT7_cGST 637834 HsxXG014284 67 C09 2159 CAPN12 NM_144691 pANT7_cGST 637835 HsxXG014284 68 D09 731 FOLR3 NM_000804 pANT7_cGST 637838 HsxXG014284 69 E09 2519 TAS1R2 NM_152232 pANT7_cGST 637840 HsxXG014284 70 F09 1292 ZNF713 NM_182633 pANT7_cGST 637845 HsxXG014284 71 G09 935 OR2M4 NM_017504 pANT7_cGST 637846 HsxXG014284 72 H09 1295 PAX2 NM_003990 pANT7_cGST 637847 HsxXG014284 73 A10 2591 MICALL1 NM_033386 pANT7_cGST 637852 HsxXG014284 74 B10 2243 AMPD1 NM_000036 pANT7_cGST 637853 HsxXG014284 75 C10 1907 MPL NM_005373 pANT7_cGST 637854 HsxXG014284 76 D10 1094 SSTR5 NM_001053 pANT7_cGST 637863 HsxXG014284 77 E10 1934 SLC24A3 NM_020689 pANT7_cGST

Camacho-Encina M, et al. Ann Rheum Dis 2019; 0:1699ÿý1705. doi: 10.1136/annrheumdis-2019-215325 Supplementary material Ann Rheum Dis

637864 HsxXG014284 78 F10 569 IFNA16 NM_002173 pANT7_cGST 637865 HsxXG014284 79 G10 428 PLA2G2E NM_014589 pANT7_cGST 637871 HsxXG014284 80 H10 935 OR5P3 NM_153445 pANT7_cGST 637874 HsxXG014284 81 A11 662 STARD6 NM_139171 pANT7_cGST 637878 HsxXG014284 82 B11 1325 HTR3B NM_006028 pANT7_cGST 637881 HsxXG014284 83 C11 3053 KCNH4 NM_012285 pANT7_cGST 637890 HsxXG014284 84 D11 5120 XRN1 NM_019001 pANT7_cGST 637895 HsxXG014284 85 E11 1121 ZP3 NM_007155 pANT7_cGST 637898 HsxXG014284 86 F11 446 ADM2 NM_024866 pANT7_cGST 637899 HsxXG014284 87 G11 1760 GAB3 NM_080612 pANT7_cGST 637900 HsxXG014284 88 H11 1004 MOGAT1 NM_058165 pANT7_cGST 637902 HsxXG014284 89 A12 1055 TAAR2 NM_001033080 pANT7_cGST 637906 HsxXG014284 90 B12 938 OR7D2 NM_175883 pANT7_cGST 637908 HsxXG014284 91 C12 2156 SLC5A3 NM_006933 pANT7_cGST 637918 HsxXG014284 92 D12 1604 AYTL2 NM_024830 pANT7_cGST 637919 HsxXG014284 93 E12 1592 UGT2B17 NM_001077 pANT7_cGST 637921 HsxXG014284 94 F12 221 DEFB108B NM_001002035 pANT7_cGST 637926 HsxXG014284 95 G12 1301 GJA8 NM_005267 pANT7_cGST HsxXG014284 96 H12 pANT7_cGST HsxXG014285 1 A01 pANT7_cGST 637930 HsxXG014285 2 B01 959 OR7C2 NM_012377 pANT7_cGST 637934 HsxXG014285 3 C01 3866 OPLAH NM_017570 pANT7_cGST 633963 HsxXG014285 4 D01 1493 CYP26A1 NM_000783 pANT7_cGST 633964 HsxXG014285 5 E01 2210 LEPREL2 NM_014262 pANT7_cGST 633966 HsxXG014285 6 F01 1040 E2F5 NM_001951 pANT7_cGST 633972 HsxXG014285 7 G01 2657 PDE8B NM_003719 pANT7_cGST 633977 HsxXG014285 8 H01 3725 NPHS1 NM_004646 pANT7_cGST 633981 HsxXG014285 9 A02 4727 LAMC3 NM_006059 pANT7_cGST 633989 HsxXG014285 10 B02 1319 GTF2E1 NM_005513 pANT7_cGST 633992 HsxXG014285 11 C02 1334 TUBB8 NM_177987 pANT7_cGST 633994 HsxXG014285 12 D02 1607 EHD3 NM_014600 pANT7_cGST 633996 HsxXG014285 13 E02 2324 HCN3 NM_020897 pANT7_cGST 634016 HsxXG014285 14 F02 1514 SLC16A8 NM_013356 pANT7_cGST 634017 HsxXG014285 15 G02 2273 KCNC3 NM_004977 pANT7_cGST 638445 HsxXG014285 16 H02 941 OR51A2 NM_001004748 pANT7_cGST 638447 HsxXG014285 17 A03 3299 SLC12A1 NM_000338 pANT7_cGST 638454 HsxXG014285 18 B03 1466 SRMS NM_080823 pANT7_cGST 638460 HsxXG014285 19 C03 3005 ATP2A1 NM_173201 pANT7_cGST

Camacho-Encina M, et al. Ann Rheum Dis 2019; 0:1699ÿý1705. doi: 10.1136/annrheumdis-2019-215325 Supplementary material Ann Rheum Dis

638464 HsxXG014285 20 D03 266 DEFB115 NM_001037730 pANT7_cGST 638468 HsxXG014285 21 E03 461 NMS NM_001011717 pANT7_cGST 638472 HsxXG014285 22 F03 1778 TGFBR2 NM_001024847 pANT7_cGST 638473 HsxXG014285 23 G03 938 OR6C2 NM_054105 pANT7_cGST 638476 HsxXG014285 24 H03 1427 ZNF383 NM_152604 pANT7_cGST 638478 HsxXG014285 25 A04 1283 KCNJ2 NM_000891 pANT7_cGST 638481 HsxXG014285 26 B04 584 PDC NM_022576 pANT7_cGST 638501 HsxXG014285 27 C04 4160 ROBO3 NM_022370 pANT7_cGST 638502 HsxXG014285 28 D04 1811 GALNT10 NM_198321 pANT7_cGST 638507 HsxXG014285 29 E04 2171 DLL1 NM_005618 pANT7_cGST 638517 HsxXG014285 30 F04 2510 CDCP1 NM_022842 pANT7_cGST 638518 HsxXG014285 31 G04 3539 SEC31B NM_015490 pANT7_cGST 638520 HsxXG014285 32 H04 827 KCNMB3 NM_171830 pANT7_cGST 638521 HsxXG014285 33 A05 1538 SLC2A7 NM_207420 pANT7_cGST 638522 HsxXG014285 34 B05 1256 NTSR1 NM_002531 pANT7_cGST 638523 HsxXG014285 35 C05 590 CHP2 NM_022097 pANT7_cGST 638524 HsxXG014285 36 D05 4706 PLXNC1 NM_005761 pANT7_cGST 638528 HsxXG014285 37 E05 875 POU1F1 NM_000306 pANT7_cGST 658073 HsxXG014285 38 F05 1589 GPR161 NM_153832 pANT7_cGST 658074 HsxXG014285 39 G05 1406 ADCYAP1R1 NM_001118 pANT7_cGST 658075 HsxXG014285 40 H05 1328 EDNRB NM_000115 pANT7_cGST 658076 HsxXG014285 41 A06 4568 BAI3 NM_001704 pANT7_cGST 658077 HsxXG014285 42 B06 2081 GPR56 NM_005682 pANT7_cGST 658080 HsxXG014285 43 C06 1196 TACR2 NM_001057 pANT7_cGST 658081 HsxXG014285 44 D06 1082 IL8RB NM_001557 pANT7_cGST 658082 HsxXG014285 45 E06 1445 HTR2B NM_000867 pANT7_cGST 658083 HsxXG014285 46 F06 959 GPR171 NM_013308 pANT7_cGST 658084 HsxXG014285 47 G06 1172 HTR1B NM_000863 pANT7_cGST 658085 HsxXG014285 48 H06 1463 HRH1 NM_000861 pANT7_cGST 658086 HsxXG014285 49 A07 1073 CCR9 NM_006641 pANT7_cGST 658087 HsxXG014285 50 B07 1160 PTGIR NM_000960 pANT7_cGST 658089 HsxXG014285 51 C07 1085 GPR25 NM_005298 pANT7_cGST 658091 HsxXG014285 52 D07 1013 PNR NM_003967 pANT7_cGST 658093 HsxXG014285 53 E07 1271 GHRHR NM_000823 pANT7_cGST 658094 HsxXG014285 54 F07 1082 CNR2 NM_001841 pANT7_cGST 658096 HsxXG014285 55 G07 1232 NTSR2 NM_012344 pANT7_cGST 658098 HsxXG014285 56 H07 2363 SMO NM_005631 pANT7_cGST 658108 HsxXG014285 57 A08 869 GHSR NM_004122 pANT7_cGST

Camacho-Encina M, et al. Ann Rheum Dis 2019; 0:1699ÿý1705. doi: 10.1136/annrheumdis-2019-215325 Supplementary material Ann Rheum Dis

658109 HsxXG014285 58 B08 1136 MAS1L NM_052967 pANT7_cGST 658112 HsxXG014285 59 C08 992 GPBAR1 NM_170699 pANT7_cGST 658115 HsxXG014285 60 D08 1322 SCTR NM_002980 pANT7_cGST 658117 HsxXG014285 61 E08 1001 P2RY13 NM_176894 pANT7_cGST 658119 HsxXG014285 62 F08 1019 P2RY10 NM_014499 pANT7_cGST 658120 HsxXG014285 63 G08 1154 EDG6 NM_003775 pANT7_cGST 658122 HsxXG014285 64 H08 1055 FPRL1 NM_001462 pANT7_cGST 658123 HsxXG014285 65 A09 2885 GABBR1 NM_001470 pANT7_cGST 658124 HsxXG014285 66 B09 1724 FZD7 NM_003507 pANT7_cGST 658126 HsxXG014285 67 C09 938 OR5BF1 NM_001001918 pANT7_cGST 658131 HsxXG014285 68 D09 1352 ADRA2B NM_000682 pANT7_cGST 658132 HsxXG014285 69 E09 1400 ADRA1A NM_000680 pANT7_cGST 658133 HsxXG014285 70 F09 1718 ADRA1D NM_000678 pANT7_cGST 658134 HsxXG014285 71 G09 998 MC4R NM_005912 pANT7_cGST 658135 HsxXG014285 72 H09 992 FFAR2 NM_005306 pANT7_cGST 658136 HsxXG014285 73 A10 1439 CHRM4 NM_000741 pANT7_cGST 658139 HsxXG014285 74 B10 1073 GPRC5A NM_003979 pANT7_cGST 658140 HsxXG014285 75 C10 959 GPR55 NM_005683 pANT7_cGST 658143 HsxXG014285 76 D10 1127 PPYR1 NM_005972 pANT7_cGST 658144 HsxXG014285 77 E10 1067 CCR8 NM_005201 pANT7_cGST 637133 HsxXG014285 78 F10 1097 WNT5A NM_003392 pANT7_cGST 637134 HsxXG014285 79 G10 1157 NR2E1 NM_003269 pANT7_cGST 637135 HsxXG014285 80 H10 1313 PRV1 NM_020406 pANT7_cGST 637136 HsxXG014285 81 A11 809 IL1B NM_000576 pANT7_cGST 637137 HsxXG014285 82 B11 857 SULT2A1 NM_003167 pANT7_cGST 637140 HsxXG014285 83 C11 1127 GPR30 NM_001505 pANT7_cGST 637143 HsxXG014285 84 D11 818 IGFBP5 NM_000599 pANT7_cGST 637144 HsxXG014285 85 E11 1007 CTSH NM_004390 pANT7_cGST 637147 HsxXG014285 86 F11 1334 GATA3 BC006793.1 pANT7_cGST 637148 HsxXG014285 87 G11 1664 BC021117.1 pANT7_cGST 637150 HsxXG014285 88 H11 1268 MAPK10 NM_002753 pANT7_cGST 637151 HsxXG014285 89 A12 683 PRL NM_000948 pANT7_cGST 637153 HsxXG014285 90 B12 200 BC013289.1 pANT7_cGST 637157 HsxXG014285 91 C12 1451 KRT8 NM_002273 pANT7_cGST 637160 HsxXG014285 92 D12 1379 FKBP4 NM_002014 pANT7_cGST 637161 HsxXG014285 93 E12 941 TYMS NM_001071 pANT7_cGST 637164 HsxXG014285 94 F12 1097 WNT14 NM_003395 pANT7_cGST 637165 HsxXG014285 95 G12 338 SCYA27 NM_006664 pANT7_cGST

Camacho-Encina M, et al. Ann Rheum Dis 2019; 0:1699ÿý1705. doi: 10.1136/annrheumdis-2019-215325 Supplementary material Ann Rheum Dis

HsxXG014285 96 H12 pANT7_cGST HsxXG014286 1 A01 pANT7_cGST 637166 HsxXG014286 2 B01 398 IL13 NM_002188 pANT7_cGST 637169 HsxXG014286 3 C01 536 IL10 NM_000572 pANT7_cGST 637172 HsxXG014286 4 D01 653 CSH BC020756.1 pANT7_cGST 637174 HsxXG014286 5 E01 1391 CTSC NM_001814 pANT7_cGST 637175 HsxXG014286 6 F01 911 CTSZ NM_001336 pANT7_cGST 637176 HsxXG014286 7 G01 299 IL8 NM_000584 pANT7_cGST 637178 HsxXG014286 8 H01 1082 WNT2 NM_003391 pANT7_cGST 637179 HsxXG014286 9 A02 434 IL9 NM_000590 pANT7_cGST 637180 HsxXG014286 10 B02 461 IL4 NM_000589 pANT7_cGST 637183 HsxXG014286 11 C02 533 IL7 NM_000880 pANT7_cGST 637193 HsxXG014286 12 D02 653 GRB2 NM_002086 pANT7_cGST 637195 HsxXG014286 13 E02 350 SST NM_001048 pANT7_cGST 637198 HsxXG014286 14 F02 776 BC016041.1 pANT7_cGST 637201 HsxXG014286 15 G02 1202 BC007628.1 pANT7_cGST 637204 HsxXG014286 16 H02 950 AKR1B1 NM_001628 pANT7_cGST 658145 HsxXG014286 17 A03 1199 BRS3 NM_001727 pANT7_cGST 658146 HsxXG014286 18 B03 1088 CCR10 NM_016602 pANT7_cGST 658147 HsxXG014286 19 C03 1082 CCR4 NM_005508 pANT7_cGST 658149 HsxXG014286 20 D03 1052 IL8RA NM_000634 pANT7_cGST 658150 HsxXG014286 21 E03 1013 GPR65 NM_003608 pANT7_cGST 658152 HsxXG014286 22 F03 1088 CXCR7 NM_020311 pANT7_cGST 658153 HsxXG014286 23 G03 929 GPR35 NM_005301 pANT7_cGST 658154 HsxXG014286 24 H03 2660 EMR1 NM_001974 pANT7_cGST 658155 HsxXG014286 25 A04 1037 GPRC5D NM_018654 pANT7_cGST 658156 HsxXG014286 26 B04 1079 HRH2 NM_022304 pANT7_cGST 658163 HsxXG014286 27 C04 1274 GPR143 NM_000273 pANT7_cGST 658164 HsxXG014286 28 D04 1103 GPR17 NM_005291 pANT7_cGST 658165 HsxXG014286 29 E04 1247 GPR19 NM_006143 pANT7_cGST 658166 HsxXG014286 30 F04 1148 EDG1 NM_001400 pANT7_cGST 658167 HsxXG014286 31 G04 1136 EDG3 NM_005226 pANT7_cGST 658169 HsxXG014286 32 H04 1079 AGTR1 NM_000685 pANT7_cGST 658171 HsxXG014286 33 A05 1055 EDG4 NM_004720 pANT7_cGST 658172 HsxXG014286 34 B05 1061 EDG5 NM_004230 pANT7_cGST 658174 HsxXG014286 35 C05 1283 EDNRA NM_001957 pANT7_cGST 658175 HsxXG014286 36 D05 1094 EDG2 NM_001401 pANT7_cGST 658177 HsxXG014286 37 E05 1028 TYMSTR NM_006564 pANT7_cGST

Camacho-Encina M, et al. Ann Rheum Dis 2019; 0:1699ÿý1705. doi: 10.1136/annrheumdis-2019-215325 Supplementary material Ann Rheum Dis

658181 HsxXG014286 38 F05 1133 P2RY2 NM_002564 pANT7_cGST 658182 HsxXG014286 39 G05 1142 OPRK1 NM_000912 pANT7_cGST 658183 HsxXG014286 40 H05 1598 CHRM5 NM_012125 pANT7_cGST 658185 HsxXG014286 41 A06 1757 FZD5 NM_003468 pANT7_cGST 658186 HsxXG014286 42 B06 1067 GPR1 NM_005279 pANT7_cGST 658188 HsxXG014286 43 C06 1259 GPR63 NM_030784 pANT7_cGST 658190 HsxXG014286 44 D06 1049 GPR21 NM_005294 pANT7_cGST 658191 HsxXG014286 45 E06 1124 CCR6 NM_031409 pANT7_cGST 658193 HsxXG014286 46 F06 1079 AGTR1 NM_032049 pANT7_cGST 658195 HsxXG014286 47 G06 1124 F2RL2 NM_004101 pANT7_cGST 658196 HsxXG014286 48 H06 1073 HTR5A NM_024012 pANT7_cGST 658197 HsxXG014286 49 A07 1277 F2R NM_001992 pANT7_cGST 658199 HsxXG014286 50 B07 1190 GPR84 NM_020370 pANT7_cGST 658201 HsxXG014286 51 C07 1622 GPR75 NM_006794 pANT7_cGST 658202 HsxXG014286 52 D07 1343 CCKBR NM_176875 pANT7_cGST 658204 HsxXG014286 53 E07 1127 GPR27 NM_018971 pANT7_cGST 658205 HsxXG014286 54 F07 1208 OPN3 NM_014322 pANT7_cGST 658206 HsxXG014286 55 G07 2072 ELTD1 NM_022159 pANT7_cGST 658207 HsxXG014286 56 H07 1034 P2RY5 NM_005767 pANT7_cGST 658208 HsxXG014286 57 A08 1247 CRHR1 NM_004382 pANT7_cGST 658209 HsxXG014286 58 B08 1154 PROKR2 NM_144773 pANT7_cGST 658210 HsxXG014286 59 C08 1076 GPR20 NM_005293 pANT7_cGST 658211 HsxXG014286 60 D08 2228 CD97 NM_001784 pANT7_cGST 658212 HsxXG014286 61 E08 1136 CCR7 NM_001838 pANT7_cGST 658214 HsxXG014286 62 F08 1154 CCBP2 NM_001296 pANT7_cGST 658215 HsxXG014286 63 G08 1187 GPR44 NM_004778 pANT7_cGST 658216 HsxXG014286 64 H08 1013 GPR77 NM_018485 pANT7_cGST 637035 HsxXG014286 65 A09 1844 NCOA BC001562.1 pANT7_cGST 637040 HsxXG014286 66 B09 569 HRAS NM_005343 pANT7_cGST 637042 HsxXG014286 67 C09 596 AY004255 pANT7_cGST 637044 HsxXG014286 68 D09 653 M15353 pANT7_cGST 637045 HsxXG014286 69 E09 701 BCL2L1 BC019307.1 pANT7_cGST 637046 HsxXG014286 70 F09 824 Z35491 pANT7_cGST 637048 HsxXG014286 71 G09 869 GDB M90813 pANT7_cGST 637054 HsxXG014286 72 H09 1019 Rad51 D14134 pANT7_cGST 637055 HsxXG014286 73 A10 1142 FEN1 NM_004111 pANT7_cGST 637058 HsxXG014286 74 B10 1409 MMP1 BC013875.1 pANT7_cGST 637060 HsxXG014286 75 C10 1442 M63167 pANT7_cGST

Camacho-Encina M, et al. Ann Rheum Dis 2019; 0:1699ÿý1705. doi: 10.1136/annrheumdis-2019-215325 Supplementary material Ann Rheum Dis

637068 HsxXG014286 76 D10 254 TFF1 NM_003225 pANT7_cGST 637071 HsxXG014286 77 E10 590 ARHB NM_004040 pANT7_cGST 637074 HsxXG014286 78 F10 614 X03655 pANT7_cGST 637076 HsxXG014286 79 G10 746 SFN BC000995 pANT7_cGST 637080 HsxXG014286 80 H10 1043 MAP2K3 NM_145109 pANT7_cGST 637087 HsxXG014286 81 A11 758 OSM BC011589 pANT7_cGST 637088 HsxXG014286 82 B11 623 FGF16 NM_003868 pANT7_cGST 637089 HsxXG014286 83 C11 626 FGF10 NM_004465 pANT7_cGST 637101 HsxXG014286 84 D11 887 CCND1 BC025302 pANT7_cGST 637108 HsxXG014286 85 E11 581 IL18 NM_001562 pANT7_cGST 637113 HsxXG014286 86 F11 1181 TP53 M14695 pANT7_cGST 637117 HsxXG014286 87 G11 896 BC014475.1 pANT7_cGST 637118 HsxXG014286 88 H11 428 BIRC BC034148.1 pANT7_cGST 654326 HsxXG014286 89 A12 2024 PPP1R15A BC003067.1 pANT7_cGST 654330 HsxXG014286 90 B12 860 SSR1 BC007710.1 pANT7_cGST 654333 HsxXG014286 91 C12 2330 DKFZp686G0852 BX537409 pANT7_cGST 643344 HsxXG014286 92 D12 1352 TAF1A BC013808.1 pANT7_cGST 643345 HsxXG014286 93 E12 2051 ABLIM3 NM_014945 pANT7_cGST 643356 HsxXG014286 94 F12 1178 BC016165.1 pANT7_cGST 643357 HsxXG014286 95 G12 2471 PDE5A NM_033437 pANT7_cGST HsxXG014286 96 H12 pANT7_cGST HsxXG014287 1 A01 pANT7_cGST 643362 HsxXG014287 2 B01 335 SCYB14 BC003513.1 pANT7_cGST 643364 HsxXG014287 3 C01 1535 PPP3C BC025714.1 pANT7_cGST 643373 HsxXG014287 4 D01 206 SEC61G BC009480 pANT7_cGST 643374 HsxXG014287 5 E01 2486 USP6N BC042943.2 pANT7_cGST 643375 HsxXG014287 6 F01 1511 CYP19A BC035959.1 pANT7_cGST 643378 HsxXG014287 7 G01 2801 PLD2 BC015033.1 pANT7_cGST 643379 HsxXG014287 8 H01 737 YWHA BC050601.1 pANT7_cGST 643383 HsxXG014287 9 A02 3137 FARP BC041595.1 pANT7_cGST 643385 HsxXG014287 10 B02 503 PTP4A2 BC070182 pANT7_cGST 643387 HsxXG014287 11 C02 1124 SPOP BC001269.1 pANT7_cGST 643388 HsxXG014287 12 D02 737 C1QG BC009016.1 pANT7_cGST 643389 HsxXG014287 13 E02 758 ORC6L BC039032 pANT7_cGST 643390 HsxXG014287 14 F02 896 JAM BC017779.1 pANT7_cGST 643394 HsxXG014287 15 G02 1256 PRKAR2 BC075800.1 pANT7_cGST 643395 HsxXG014287 16 H02 1868 PRL BC059392.1 pANT7_cGST 643396 HsxXG014287 17 A03 917 PPA BC057219.1 pANT7_cGST

Camacho-Encina M, et al. Ann Rheum Dis 2019; 0:1699ÿý1705. doi: 10.1136/annrheumdis-2019-215325 Supplementary material Ann Rheum Dis

643397 HsxXG014287 18 B03 2999 LOC14267 BC037542.1 pANT7_cGST 643420 HsxXG014287 19 C03 2960 ARHGAP BC052303.1 pANT7_cGST 643426 HsxXG014287 20 D03 2525 SOX BC047064.1 pANT7_cGST 643429 HsxXG014287 21 E03 710 BC012469.1 pANT7_cGST 638532 HsxXG014287 22 F03 3158 DKFZp451P021 AL832458 pANT7_cGST 638533 HsxXG014287 23 G03 2162 ELMO2 NM_133171 pANT7_cGST 638546 HsxXG014287 24 H03 1130 DKFZp686D18111 BX537375 pANT7_cGST 638572 HsxXG014287 25 A04 1046 DKFZp686B2082 BX537381 pANT7_cGST 638595 HsxXG014287 26 B04 3944 RNF123 NM_022064 pANT7_cGST 638596 HsxXG014287 27 C04 2627 DKFZp686A2451 BX537404 pANT7_cGST 638603 HsxXG014287 28 D04 1865 DKFZp451G104 AL832017 pANT7_cGST 638626 HsxXG014287 29 E04 1130 TMLH BC025269.1 pANT7_cGST 638632 HsxXG014287 30 F04 680 DKFZp586J1023 AL136938 pANT7_cGST 638635 HsxXG014287 31 G04 986 GRHPR BC000605 pANT7_cGST 638651 HsxXG014287 32 H04 962 DKFZp564F1062 AL713790 pANT7_cGST 638659 HsxXG014287 33 A05 398 DKFZp686N1586 BX537975 pANT7_cGST 638661 HsxXG014287 34 B05 764 YF13H12 BC008250.1 pANT7_cGST 638662 HsxXG014287 35 C05 2081 DKFZp761J057 AL713652 pANT7_cGST 638663 HsxXG014287 36 D05 968 DKFZp547E2313 AL834276 pANT7_cGST 638667 HsxXG014287 37 E05 932 SIRT5 BC000126.1 pANT7_cGST 638671 HsxXG014287 38 F05 833 DKFZp564A0772 AL161994 pANT7_cGST 638679 HsxXG014287 39 G05 263 PDE6G NM_002602 pANT7_cGST 638684 HsxXG014287 40 H05 1499 DKFZp686O24118 BX537398 pANT7_cGST 638685 HsxXG014287 41 A06 953 DKFZp686A0786 BX537399 pANT7_cGST 638689 HsxXG014287 42 B06 1619 DKFZp571K2312 AL833814 pANT7_cGST 638691 HsxXG014287 43 C06 1238 DKFZp667G0511 AL834288 pANT7_cGST 638703 HsxXG014287 44 D06 2312 DKFZp451I053 AL831992 pANT7_cGST 638704 HsxXG014287 45 E06 1142 NUP43 NM_198887 pANT7_cGST 638710 HsxXG014287 46 F06 920 ABHD10 BC014516 pANT7_cGST 638718 HsxXG014287 47 G06 1352 DKFZp434D0727 AL136826 pANT7_cGST 638734 HsxXG014287 48 H06 311 DKFZp566G013 AL050277 pANT7_cGST 638739 HsxXG014287 49 A07 620 DKFZp564C103 AL050269 pANT7_cGST 638740 HsxXG014287 50 B07 1010 DKFZp566B1046 AL136716 pANT7_cGST 638761 HsxXG014287 51 C07 1004 DKFZp564B246 AL136664 pANT7_cGST 638763 HsxXG014287 52 D07 2519 DKFZp434K0220 AL136801 pANT7_cGST 638771 HsxXG014287 53 E07 587 DKFZp586C1924 AL136941 pANT7_cGST 638773 HsxXG014287 54 F07 947 DKFZp547P1515 AL713749 pANT7_cGST 638786 HsxXG014287 55 G07 1430 DKFZp686A1551 BX537963 pANT7_cGST

Camacho-Encina M, et al. Ann Rheum Dis 2019; 0:1699ÿý1705. doi: 10.1136/annrheumdis-2019-215325 Supplementary material Ann Rheum Dis

638787 HsxXG014287 56 H07 605 DKFZp564I172 AL136635 pANT7_cGST 638790 HsxXG014287 57 A08 2672 KIF20A BC012999 pANT7_cGST 638795 HsxXG014287 58 B08 428 DKFZp564A247 AL713701 pANT7_cGST 638812 HsxXG014287 59 C08 4097 DKFZp434H0117 AL136776 pANT7_cGST 638815 HsxXG014287 60 D08 617 DKFZp434I209 AL136906 pANT7_cGST 638820 HsxXG014287 61 E08 1229 DKFZp564B1778 AL136678 pANT7_cGST 638825 HsxXG014287 62 F08 1202 DKFZp586G1919 AL136916 pANT7_cGST 638831 HsxXG014287 63 G08 2357 DKFZp434A028 AL117575 pANT7_cGST 638870 HsxXG014287 64 H08 1043 HDAC11 BC009676.1 pANT7_cGST 638883 HsxXG014287 65 A09 2366 ITGB6 NM_000888 pANT7_cGST 638889 HsxXG014287 66 B09 4133 DKFZp686C0251 BX647944 pANT7_cGST 640502 HsxXG014287 67 C09 485 TAF12 BC011986.1 pANT7_cGST 640517 HsxXG014287 68 D09 1871 BC009970.1 pANT7_cGST 640524 HsxXG014287 69 E09 1313 TGOLN2 BC008461.1 pANT7_cGST 640526 HsxXG014287 70 F09 1451 SHMT1 BC007979.1 pANT7_cGST 640536 HsxXG014287 71 G09 893 OTX BC032579.1 pANT7_cGST 640543 HsxXG014287 72 H09 422 SNCA BC013293.1 pANT7_cGST 640576 HsxXG014287 73 A10 743 GZM BC030195.1 pANT7_cGST 640577 HsxXG014287 74 B10 980 ELAVL1 BC003376.1 pANT7_cGST 640578 HsxXG014287 75 C10 767 YWHAE BC000179.2 pANT7_cGST 640581 HsxXG014287 76 D10 983 FKBP BC036817.1 pANT7_cGST 640583 HsxXG014287 77 E10 1547 BC009368.1 pANT7_cGST 640584 HsxXG014287 78 F10 1670 FLJ2350 BC025728.1 pANT7_cGST 640585 HsxXG014287 79 G10 953 HMG20B BC002552.1 pANT7_cGST 640590 HsxXG014287 80 H10 245 BC014300.1 pANT7_cGST 634287 HsxXG014287 81 A11 1316 VIPR2 BC010569.1 pANT7_cGST 634288 HsxXG014287 82 B11 1433 CAP2 BC008481.1 pANT7_cGST 634289 HsxXG014287 83 C11 1490 GPT BC018207.1 pANT7_cGST 634290 HsxXG014287 84 D11 2177 BC014924.1 pANT7_cGST 634291 HsxXG014287 85 E11 185 STK39 BC018190.1 pANT7_cGST 634295 HsxXG014287 86 F11 1025 KIR2DL BC032422.1 pANT7_cGST 634297 HsxXG014287 87 G11 1202 MVD BC000011.1 pANT7_cGST 634298 HsxXG014287 88 H11 1436 IFIT1 BC007091.1 pANT7_cGST 634299 HsxXG014287 89 A12 1553 GTF2F1 BC000120.1 pANT7_cGST 634303 HsxXG014287 90 B12 614 ARHGDIA BC016031.1 pANT7_cGST 634304 HsxXG014287 91 C12 2612 WWP2 BC013645.1 pANT7_cGST 634305 HsxXG014287 92 D12 401 IFITM3 BC006794.1 pANT7_cGST 634306 HsxXG014287 93 E12 971 AKR1C2 BC007024.1 pANT7_cGST

Camacho-Encina M, et al. Ann Rheum Dis 2019; 0:1699ÿý1705. doi: 10.1136/annrheumdis-2019-215325 Supplementary material Ann Rheum Dis

634307 HsxXG014287 94 F12 1076 DNAJB11 BC001144.1 pANT7_cGST 634323 HsxXG014287 95 G12 1097 HLA-A BC008611.1 pANT7_cGST HsxXG014287 96 H12 pANT7_cGST HsxXG014288 1 A01 pANT7_cGST 634324 HsxXG014288 2 B01 899 BC014766.1 pANT7_cGST 634329 HsxXG014288 3 C01 437 RPS19 BC000023.1 pANT7_cGST 634330 HsxXG014288 4 D01 677 GSTM3 BC000088.1 pANT7_cGST 634332 HsxXG014288 5 E01 2312 DAB2 BC003064.1 pANT7_cGST 634336 HsxXG014288 6 F01 3071 ATP1A1 BC003077.1 pANT7_cGST 634337 HsxXG014288 7 G01 3578 TBCD BC003094.1 pANT7_cGST 634340 HsxXG014288 8 H01 1550 MGC3210 BC018783.1 pANT7_cGST 634347 HsxXG014288 9 A02 662 BC016056.1 pANT7_cGST 634349 HsxXG014288 10 B02 725 PSMB1 BC000508.1 pANT7_cGST 634350 HsxXG014288 11 C02 1568 PRPF4 BC001588.1 pANT7_cGST 634355 HsxXG014288 12 D02 3740 BC015758.1 pANT7_cGST 634363 HsxXG014288 13 E02 2348 GS BC026033.1 pANT7_cGST 634369 HsxXG014288 14 F02 1322 SQSTM1 BC003139.1 pANT7_cGST 634377 HsxXG014288 15 G02 1460 BC002326.1 pANT7_cGST 637670 HsxXG014288 16 H02 677 CLDN BC020866.1 pANT7_cGST 637678 HsxXG014288 17 A03 1121 HSD3B BC031999.1 pANT7_cGST 637679 HsxXG014288 18 B03 1850 MGC4558 BC033849.2 pANT7_cGST 637680 HsxXG014288 19 C03 524 NMU BC012908.1 pANT7_cGST 637682 HsxXG014288 20 D03 2030 PROS1 BC015801.1 pANT7_cGST 637683 HsxXG014288 21 E03 2468 BC030777.1 pANT7_cGST 637684 HsxXG014288 22 F03 1712 CYB BC032720.1 pANT7_cGST 637692 HsxXG014288 23 G03 242 COX7B BC018386.1 pANT7_cGST 637699 HsxXG014288 24 H03 1136 B3GALT BC032574.1 pANT7_cGST 637700 HsxXG014288 25 A04 1151 BC034970.1 pANT7_cGST 637703 HsxXG014288 26 B04 2711 BC025989.1 pANT7_cGST 637706 HsxXG014288 27 C04 242 LSM6 BC016026.1 pANT7_cGST 637709 HsxXG014288 28 D04 1904 BC022525.1 pANT7_cGST 637711 HsxXG014288 29 E04 656 RAB27 BC027474.1 pANT7_cGST 637715 HsxXG014288 30 F04 1481 CET BC025739.1 pANT7_cGST 637717 HsxXG014288 31 G04 995 AKR7A BC025709.1 pANT7_cGST 637718 HsxXG014288 32 H04 1013 CYSLTR BC035750.1 pANT7_cGST 637725 HsxXG014288 33 A05 773 RPL8 BC013104.1 pANT7_cGST 637726 HsxXG014288 34 B05 3296 MYO1 BC028071.1 pANT7_cGST 637729 HsxXG014288 35 C05 1505 BC011523.1 pANT7_cGST

Camacho-Encina M, et al. Ann Rheum Dis 2019; 0:1699ÿý1705. doi: 10.1136/annrheumdis-2019-215325 Supplementary material Ann Rheum Dis

637735 HsxXG014288 36 D05 4277 MADHI BC032680.1 pANT7_cGST 637743 HsxXG014288 37 E05 2030 ALOX15 BC035217.1 pANT7_cGST 637745 HsxXG014288 38 F05 689 EBI3 BC015364.1 pANT7_cGST 637747 HsxXG014288 39 G05 1922 CAPN5 BC018123.1 pANT7_cGST 637749 HsxXG014288 40 H05 2021 ANXA6 BC017046.1 pANT7_cGST 637751 HsxXG014288 41 A06 2492 TCIRG1 BC018133.1 pANT7_cGST 637754 HsxXG014288 42 B06 1814 PTGS2 BC013734.1 pANT7_cGST 644390 HsxXG014288 43 C06 782 DPM1 BC008466 pANT7_cGST 644412 HsxXG014288 44 D06 872 FCGR3A BC036723 pANT7_cGST 644416 HsxXG014288 45 E06 812 GJB3 BC012918 pANT7_cGST 644422 HsxXG014288 46 F06 851 RPP38 BC029494 pANT7_cGST 644430 HsxXG014288 47 G06 956 RDH11 BC011727 pANT7_cGST 644431 HsxXG014288 48 H06 557 GINS2 BC010164 pANT7_cGST 644437 HsxXG014288 49 A07 656 EIF3K BC001031 pANT7_cGST 644440 HsxXG014288 50 B07 653 CSH1 BC005921 pANT7_cGST 644448 HsxXG014288 51 C07 800 HLA-DRB3 BC001023 pANT7_cGST 644457 HsxXG014288 52 D07 1004 SUMF2 BC015600 pANT7_cGST 644460 HsxXG014288 53 E07 884 GLYATL2 BC016789 pANT7_cGST 644462 HsxXG014288 54 F07 884 YIF1B BC014974 pANT7_cGST 644470 HsxXG014288 55 G07 983 RFFL BC028424 pANT7_cGST 644473 HsxXG014288 56 H07 989 CTSK BC016058 pANT7_cGST 644491 HsxXG014288 57 A08 1058 CHST11 BC013315 pANT7_cGST 644492 HsxXG014288 58 B08 1001 ANTXR1 BC012074 pANT7_cGST 644493 HsxXG014288 59 C08 1013 DCPS BC014532 pANT7_cGST 644500 HsxXG014288 60 D08 1205 DCTN2 BC000718 pANT7_cGST 644501 HsxXG014288 61 E08 1148 ATP6V1C1 BC010960 pANT7_cGST 644502 HsxXG014288 62 F08 1178 KTELC1 BC030614 pANT7_cGST 644503 HsxXG014288 63 G08 1199 ZNF302 BC024176 pANT7_cGST 644507 HsxXG014288 64 H08 1226 DPAGT1 BC000325 pANT7_cGST 644516 HsxXG014288 65 A09 1133 NDUFA9 BC009311 pANT7_cGST 644523 HsxXG014288 66 B09 1211 INDO BC027882 pANT7_cGST 644524 HsxXG014288 67 C09 1220 TDO2 BC005355 pANT7_cGST 644532 HsxXG014288 68 D09 1196 POLR3D BC004484 pANT7_cGST 644535 HsxXG014288 69 E09 1190 SNIP1 BC027040 pANT7_cGST 644538 HsxXG014288 70 F09 1256 ARRB1 BC003636 pANT7_cGST 644543 HsxXG014288 71 G09 1250 CASP9 BC006463 pANT7_cGST 644546 HsxXG014288 72 H09 1259 KIAA1576 BC033537 pANT7_cGST 644556 HsxXG014288 73 A10 1316 NTNG1 BC030220 pANT7_cGST

Camacho-Encina M, et al. Ann Rheum Dis 2019; 0:1699ÿý1705. doi: 10.1136/annrheumdis-2019-215325 Supplementary material Ann Rheum Dis

644557 HsxXG014288 74 B10 1277 AP1M2 BC005021 pANT7_cGST 644566 HsxXG014288 75 C10 1337 TUBB2C BC039175 pANT7_cGST 644569 HsxXG014288 76 D10 1337 MYLIP BC002860 pANT7_cGST 644581 HsxXG014288 77 E10 1388 NFIL3 BC008197 pANT7_cGST 644583 HsxXG014288 78 F10 1439 C9orf98 BC034776 pANT7_cGST 644592 HsxXG014288 79 G10 443 UBE2D4 BC004104 pANT7_cGST 644652 HsxXG014288 80 H10 863 NRBF2 BC011707 pANT7_cGST 644670 HsxXG014288 81 A11 905 ECHDC1 BC003549 pANT7_cGST 644678 HsxXG014288 82 B11 899 SC5DL BC012333 pANT7_cGST 644693 HsxXG014288 83 C11 821 KITLG BC069783 pANT7_cGST 644696 HsxXG014288 84 D11 1040 MOS BC069569 pANT7_cGST 644697 HsxXG014288 85 E11 1046 CD200R1 BC069661 pANT7_cGST 644701 HsxXG014288 86 F11 1082 MC3R BC069599 pANT7_cGST 644702 HsxXG014288 87 G11 1082 GPR15 BC069437 pANT7_cGST 644703 HsxXG014288 88 H11 1097 GPR68 BC069592 pANT7_cGST 644704 HsxXG014288 89 A12 1124 KIR2DL1 BC069344 pANT7_cGST 644706 HsxXG014288 90 B12 1376 CHRNB3 BC069681 pANT7_cGST 644708 HsxXG014288 91 C12 1472 CYP2C18 BC069666 pANT7_cGST 644716 HsxXG014288 92 D12 1220 ST6GAL1 BC031476 pANT7_cGST 644717 HsxXG014288 93 E12 1118 LMX1B BC069601 pANT7_cGST 644719 HsxXG014288 94 F12 1589 KCNA6 BC069355 pANT7_cGST 644721 HsxXG014288 95 G12 1163 PTPN2 BC008244 pANT7_cGST HsxXG014288 96 H12 pANT7_cGST HsxXG014289 1 A01 pANT7_cGST 644722 HsxXG014289 2 B01 1322 AADACL1 BC028734 pANT7_cGST 644726 HsxXG014289 3 C01 596 BCL2L11 BC033694 pANT7_cGST 644735 HsxXG014289 4 D01 455 MYL6 BC071661 pANT7_cGST 644746 HsxXG014289 5 E01 1280 RAD9B BC068031 pANT7_cGST 644747 HsxXG014289 6 F01 866 CENPP BC071726 pANT7_cGST 644751 HsxXG014289 7 G01 959 SPRY1 BC063856 pANT7_cGST 644755 HsxXG014289 8 H01 1130 AGPAT3 BC063552 pANT7_cGST 644761 HsxXG014289 9 A02 803 PHCA BC073853 pANT7_cGST 644762 HsxXG014289 10 B02 1322 GORASP1 BC075854 pANT7_cGST 644768 HsxXG014289 11 C02 1577 PRKAG2 BC068598 pANT7_cGST 644769 HsxXG014289 12 D02 1310 KCNG3 BC071558 pANT7_cGST 644771 HsxXG014289 13 E02 488 IL21 BC066259 pANT7_cGST 644772 HsxXG014289 14 F02 530 RPL18A BC066319 pANT7_cGST 644773 HsxXG014289 15 G02 677 GRPEL2 BC070090 pANT7_cGST

Camacho-Encina M, et al. Ann Rheum Dis 2019; 0:1699ÿý1705. doi: 10.1136/annrheumdis-2019-215325 Supplementary material Ann Rheum Dis

644775 HsxXG014289 16 H02 1286 FBXL3 BC072448 pANT7_cGST 644783 HsxXG014289 17 A03 626 RPS8 BC070875 pANT7_cGST 644789 HsxXG014289 18 B03 998 CHORDC1 BC072461 pANT7_cGST 644790 HsxXG014289 19 C03 1001 NPBWR2 BC067481 pANT7_cGST 644791 HsxXG014289 20 D03 1001 GJA4 BC072389 pANT7_cGST 644795 HsxXG014289 21 E03 1271 GPR83 BC067473 pANT7_cGST 644799 HsxXG014289 22 F03 785 ALKBH2 BC070489 pANT7_cGST 644808 HsxXG014289 23 G03 992 CFHR3 BC058009 pANT7_cGST 644810 HsxXG014289 24 H03 1109 DHPS BC000333 pANT7_cGST 644825 HsxXG014289 25 A04 833 M6PR BC024206 pANT7_cGST 644840 HsxXG014289 26 B04 731 IL27 BC062422 pANT7_cGST 644841 HsxXG014289 27 C04 758 PIGL BC068197 pANT7_cGST 644901 HsxXG014289 28 D04 605 DYNC2LI1 BC058823 pANT7_cGST 644912 HsxXG014289 29 E04 881 FBXO6 BC020880 pANT7_cGST 644927 HsxXG014289 30 F04 1142 ADH4 BC022319 pANT7_cGST 644930 HsxXG014289 31 G04 1358 PAH BC026251 pANT7_cGST 644931 HsxXG014289 32 H04 1382 ANGPTL3 BC058287 pANT7_cGST 644932 HsxXG014289 33 A05 1124 PTGER3 BC024229 pANT7_cGST 644935 HsxXG014289 34 B05 1364 PIK3R1 BC030815 pANT7_cGST 644942 HsxXG014289 35 C05 512 CAMP BC055089 pANT7_cGST 644947 HsxXG014289 36 D05 641 RAB4B BC046927 pANT7_cGST 644955 HsxXG014289 37 E05 611 GPX1 BC007865 pANT7_cGST 644881 HsxXG014289 38 F05 788 CA13 BC052602 pANT7_cGST 644882 HsxXG014289 39 G05 812 PITPNA BC045108 pANT7_cGST 644895 HsxXG014289 40 H05 1049 WNT7B BC034923 pANT7_cGST 644899 HsxXG014289 41 A06 1103 AHSG BC052590 pANT7_cGST 645000 HsxXG014289 42 B06 1250 TRAF1 BC024145 pANT7_cGST 645014 HsxXG014289 43 C06 464 ARPC5 BC057237 pANT7_cGST 645024 HsxXG014289 44 D06 602 HFE2 BC017926 pANT7_cGST 645082 HsxXG014289 45 E06 977 AEN BC020988 pANT7_cGST 645083 HsxXG014289 46 F06 959 PYCR1 BC001504 pANT7_cGST 645102 HsxXG014289 47 G06 1022 GNB4 BC000873 pANT7_cGST 645105 HsxXG014289 48 H06 1037 GMPR BC008281 pANT7_cGST 645107 HsxXG014289 49 A07 1025 QKI BC019917 pANT7_cGST 645108 HsxXG014289 50 B07 1037 NDEL1 BC026101 pANT7_cGST 645110 HsxXG014289 51 C07 1031 BDH1 BC011964 pANT7_cGST 645120 HsxXG014289 52 D07 1097 SULT2B1 BC034694 pANT7_cGST 645134 HsxXG014289 53 E07 1148 MAPKAPK3 BC007591 pANT7_cGST

Camacho-Encina M, et al. Ann Rheum Dis 2019; 0:1699ÿý1705. doi: 10.1136/annrheumdis-2019-215325 Supplementary material Ann Rheum Dis

645151 HsxXG014289 54 F07 1289 AADAT BC031068 pANT7_cGST 645162 HsxXG014289 55 G07 1337 TUBB2B BC001352 pANT7_cGST 645165 HsxXG014289 56 H07 1424 CORO1C BC002342 pANT7_cGST 645187 HsxXG014289 57 A08 377 Magmas BC005024 pANT7_cGST 645215 HsxXG014289 58 B08 620 SNAP25 BC010647 pANT7_cGST 645234 HsxXG014289 59 C08 827 ATG5 BC002699 pANT7_cGST 645242 HsxXG014289 60 D08 938 OR2L13 BC028158 pANT7_cGST 645256 HsxXG014289 61 E08 563 DHFRL1 BC045541 pANT7_cGST 645262 HsxXG014289 62 F08 785 RCHY1 BC047393 pANT7_cGST 645267 HsxXG014289 63 G08 908 RNF144B BC063311 pANT7_cGST 645276 HsxXG014289 64 H08 632 FXN BC048097 pANT7_cGST 645282 HsxXG014289 65 A09 797 ZDHHC21 BC042558 pANT7_cGST 645300 HsxXG014289 66 B09 1619 KPNA5 BC047409 pANT7_cGST 645301 HsxXG014289 67 C09 1070 PCBP1 BC039742 pANT7_cGST 645317 HsxXG014289 68 D09 668 GSTA1 BC053578 pANT7_cGST 645321 HsxXG014289 69 E09 707 DUSP15 BC056911 pANT7_cGST 645344 HsxXG014289 70 F09 908 ICOSLG BC064637 pANT7_cGST 645364 HsxXG014289 71 G09 1157 DCP2 BC064593 pANT7_cGST 645380 HsxXG014289 72 H09 824 ASB7 BC063581 pANT7_cGST 645381 HsxXG014289 73 A10 1220 LCOR BC053359 pANT7_cGST 658950 HsxXG014289 74 B10 1130 CHST14 BC049214 pANT7_cGST 658952 HsxXG014289 75 C10 656 GSTM5 BC058881 pANT7_cGST 658955 HsxXG014289 76 D10 743 PRSS3 BC069494 pANT7_cGST 658956 HsxXG014289 77 E10 599 ICOS BC028210 pANT7_cGST 658959 HsxXG014289 78 F10 728 APIP BC017594 pANT7_cGST 658972 HsxXG014289 79 G10 848 PNMT BC037246 pANT7_cGST 658985 HsxXG014289 80 H10 902 GGPS1 BC005252 pANT7_cGST 658993 HsxXG014289 81 A11 512 NTS BC010918 pANT7_cGST 659000 HsxXG014289 82 B11 896 ATP5C1 BC016812 pANT7_cGST 659005 HsxXG014289 83 C11 992 WDR77 BC009411 pANT7_cGST 659016 HsxXG014289 84 D11 1520 CDK5RAP3 BC009957 pANT7_cGST 658859 HsxXG014289 85 E11 893 CNN1 BC022015 pANT7_cGST 658860 HsxXG014289 86 F11 1004 WDR5 BC001635 pANT7_cGST 658861 HsxXG014289 87 G11 1022 GNB2 BC010073 pANT7_cGST 658867 HsxXG014289 88 H11 1040 POLR1C BC008863 pANT7_cGST 658868 HsxXG014289 89 A12 1109 ZNF707 BC014894 pANT7_cGST 658869 HsxXG014289 90 B12 1094 SLC35C1 BC001427 pANT7_cGST 658874 HsxXG014289 91 C12 1085 HMBS BC008149 pANT7_cGST

Camacho-Encina M, et al. Ann Rheum Dis 2019; 0:1699ÿý1705. doi: 10.1136/annrheumdis-2019-215325 Supplementary material Ann Rheum Dis

658876 HsxXG014289 92 D12 1109 MGC3207 BC001703 pANT7_cGST 658883 HsxXG014289 93 E12 1127 UBE2Q2 BC017708 pANT7_cGST 658886 HsxXG014289 94 F12 1199 TERF2IP BC004465 pANT7_cGST 658889 HsxXG014289 95 G12 1151 DLK1 BC007741 pANT7_cGST HsxXG014289 96 H12 pANT7_cGST HsxXG014290 1 A01 pANT7_cGST 658892 HsxXG014290 2 B01 1169 KLHDC3 BC009460 pANT7_cGST 658893 HsxXG014290 3 C01 1124 GNA15 BC013585 pANT7_cGST 658894 HsxXG014290 4 D01 1187 GNAS BC008855 pANT7_cGST 658896 HsxXG014290 5 E01 1139 GALT BC015045 pANT7_cGST 658904 HsxXG014290 6 F01 1205 RBM17 BC007871 pANT7_cGST 658910 HsxXG014290 7 G01 1253 MTERFD1 BC012995 pANT7_cGST 658916 HsxXG014290 8 H01 1220 RBMS1 BC018951 pANT7_cGST 658917 HsxXG014290 9 A02 1271 SERPINA3 BC010530 pANT7_cGST 658918 HsxXG014290 10 B02 1289 SLC37A4 BC015650 pANT7_cGST 658925 HsxXG014290 11 C02 1361 DLST BC000302 pANT7_cGST 658926 HsxXG014290 12 D02 1295 EIF5 BC007728 pANT7_cGST 658931 HsxXG014290 13 E02 1340 CALCOCO2 BC015893 pANT7_cGST 658932 HsxXG014290 14 F02 1316 GCNT3 BC017032 pANT7_cGST 658935 HsxXG014290 15 G02 1406 ERO1L BC012941 pANT7_cGST 658943 HsxXG014290 16 H02 1427 PARS2 BC007956 pANT7_cGST 658948 HsxXG014290 17 A03 1424 SHC1 BC014158 pANT7_cGST 658949 HsxXG014290 18 B03 1409 KLF10 BC011538 pANT7_cGST 656945 HsxXG014290 19 C03 329 RPRM BC002908 pANT7_cGST 656972 HsxXG014290 20 D03 530 VPS25 BC006282 pANT7_cGST 656978 HsxXG014290 21 E03 602 CDO1 BC024241 pANT7_cGST 656986 HsxXG014290 22 F03 632 POLR2E BC004441 pANT7_cGST 656990 HsxXG014290 23 G03 572 DCTN6 BC013175 pANT7_cGST 656992 HsxXG014290 24 H03 1493 UGP2 BC002954 pANT7_cGST 656996 HsxXG014290 25 A04 1568 PLXNA4 BC028744 pANT7_cGST 658768 HsxXG014290 26 B04 662 TIMP2 BC052605 pANT7_cGST 658769 HsxXG014290 27 C04 701 C21orf45 BC042917 pANT7_cGST 658772 HsxXG014290 28 D04 1097 CD244 BC053985 pANT7_cGST 658775 HsxXG014290 29 E04 1160 TNFRSF10D BC052270 pANT7_cGST 658783 HsxXG014290 30 F04 1133 KIR2DL4 BC041611 pANT7_cGST 658789 HsxXG014290 31 G04 305 GAS BC069724 pANT7_cGST 658796 HsxXG014290 32 H04 383 CCL28 BC069532 pANT7_cGST 658799 HsxXG014290 33 A05 404 RBP2 BC069522 pANT7_cGST

Camacho-Encina M, et al. Ann Rheum Dis 2019; 0:1699ÿý1705. doi: 10.1136/annrheumdis-2019-215325 Supplementary material Ann Rheum Dis

658800 HsxXG014290 34 B05 410 HIST1H3A BC069303 pANT7_cGST 658801 HsxXG014290 35 C05 416 TSHB BC069298 pANT7_cGST 658804 HsxXG014290 36 D05 269 CCL18 BC069700 pANT7_cGST 658805 HsxXG014290 37 E05 299 DEFB127 BC069486 pANT7_cGST 658808 HsxXG014290 38 F05 425 CALCA BC069760 pANT7_cGST 658812 HsxXG014290 39 G05 461 GIP BC069663 pANT7_cGST 658815 HsxXG014290 40 H05 503 LEP BC069323 pANT7_cGST 658817 HsxXG014290 41 A06 521 CRYAA BC069528 pANT7_cGST 658821 HsxXG014290 42 B06 542 RGS8 BC069677 pANT7_cGST 658836 HsxXG014290 43 C06 764 KLK4 BC069429 pANT7_cGST 658838 HsxXG014290 44 D06 785 RPA4 BC069791 pANT7_cGST 658839 HsxXG014290 45 E06 797 CER1 BC069503 pANT7_cGST 658845 HsxXG014290 46 F06 905 AQP10 BC069607 pANT7_cGST 658847 HsxXG014290 47 G06 917 CLDN16 BC069759 pANT7_cGST 658848 HsxXG014290 48 H06 977 MAS1 BC069581 pANT7_cGST 658850 HsxXG014290 49 A07 1001 EFNB2 BC069342 pANT7_cGST 658857 HsxXG014290 50 B07 773 NTF3 BC069773 pANT7_cGST 658682 HsxXG014290 51 C07 1196 IL1R2 BC039031 pANT7_cGST 658683 HsxXG014290 52 D07 1205 KCNAB1 BC043166 pANT7_cGST 658687 HsxXG014290 53 E07 1256 PELI1 BC050019 pANT7_cGST 658692 HsxXG014290 54 F07 1376 ZNF19 BC047091 pANT7_cGST 658695 HsxXG014290 55 G07 1592 ZNF529 BC064690 pANT7_cGST 658707 HsxXG014290 56 H07 257 CDC26 BC066300 pANT7_cGST 658710 HsxXG014290 57 A08 668 UBE2S BC066948 pANT7_cGST 658723 HsxXG014290 58 B08 917 ST6GALNAC3 BC059363 pANT7_cGST 658727 HsxXG014290 59 C08 1007 MAGT1 BC060842 pANT7_cGST 658733 HsxXG014290 60 D08 1118 PARD6B BC060847 pANT7_cGST 658734 HsxXG014290 61 E08 791 PSMB5 BC057840 pANT7_cGST 658736 HsxXG014290 62 F08 923 HS3ST1 BC057803 pANT7_cGST 658747 HsxXG014290 63 G08 1208 ZCCHC12 BC057841 pANT7_cGST 658752 HsxXG014290 64 H08 1334 VPS4B BC039574 pANT7_cGST 658755 HsxXG014290 65 A09 1199 P2RX1 BC044657 pANT7_cGST 658756 HsxXG014290 66 B09 1322 SOCS4 BC060790 pANT7_cGST 658757 HsxXG014290 67 C09 1364 CDCA7L BC039823 pANT7_cGST 658766 HsxXG014290 68 D09 206 DEFB1 BC047677 pANT7_cGST 658589 HsxXG014290 69 E09 542 SPCS3 BC047290 pANT7_cGST 658596 HsxXG014290 70 F09 710 PEMT BC050593 pANT7_cGST 658597 HsxXG014290 71 G09 731 CPSF4 BC050738 pANT7_cGST

Camacho-Encina M, et al. Ann Rheum Dis 2019; 0:1699ÿý1705. doi: 10.1136/annrheumdis-2019-215325 Supplementary material Ann Rheum Dis

658605 HsxXG014290 72 H09 830 STX12 BC046999 pANT7_cGST 658619 HsxXG014290 73 A10 767 AQP8 BC040630 pANT7_cGST 658641 HsxXG014290 74 B10 1127 ST3GAL3 BC050380 pANT7_cGST 658644 HsxXG014290 75 C10 1160 ADIPOR2 BC051858 pANT7_cGST 658647 HsxXG014290 76 D10 1220 REN BC047752 pANT7_cGST 658649 HsxXG014290 77 E10 1271 MPI BC046357 pANT7_cGST 658650 HsxXG014290 78 F10 1277 SYT6 BC044948 pANT7_cGST 658651 HsxXG014290 79 G10 1301 SLC39A6 BC039498 pANT7_cGST 658655 HsxXG014290 80 H10 965 CTSO BC049206 pANT7_cGST 658676 HsxXG014290 81 A11 404 RBP7 BC063013 pANT7_cGST 658499 HsxXG014290 82 B11 950 RDH12 BC025724 pANT7_cGST 658501 HsxXG014290 83 C11 923 CDK5R1 BC026347 pANT7_cGST 658503 HsxXG014290 84 D11 905 NOSIP BC009299 pANT7_cGST 658505 HsxXG014290 85 E11 275 LSM5 BC005938 pANT7_cGST 658507 HsxXG014290 86 F11 254 RPS27L BC003667 pANT7_cGST 658514 HsxXG014290 87 G11 329 CXCL13 BC012589 pANT7_cGST 658515 HsxXG014290 88 H11 350 CGA BC010957 pANT7_cGST 658520 HsxXG014290 89 A12 503 MRPS24 BC012167 pANT7_cGST 658522 HsxXG014290 90 B12 584 BNIP3 BC021989 pANT7_cGST 658525 HsxXG014290 91 C12 605 CHMP6 BC010108 pANT7_cGST 658527 HsxXG014290 92 D12 596 SAR1A BC003658 pANT7_cGST 658535 HsxXG014290 93 E12 620 NAT14 BC019079 pANT7_cGST 658545 HsxXG014290 94 F12 650 GSTZ1 BC001453 pANT7_cGST 658546 HsxXG014290 95 G12 737 TPMT BC005339 pANT7_cGST HsxXG014290 96 H12 pANT7_cGST

Camacho-Encina M, et al. Ann Rheum Dis 2019; 0:1699ÿý1705. doi: 10.1136/annrheumdis-2019-215325 Supplementary material Ann Rheum Dis

Supplementary Table S2. Selected non-radiographic clinical variables as predictors of incident knee OA. Variable name Recoded to Description in OAI database target knee V00AGE Age (calc, used for study eligibility) NO P02SEX Gender, male or female NO P01BMI Body mass index (calc) NO P02JBMP Observe obvious hard bumps on joints closest to fingertips NO P02JBMPCV Hard bumps on fingers of right hand, left hand or both hands (calc, if=3 used for study) NO P01RHBE Right hand exam: total number of bony enlargements (calc) NO P01LHBE Left hand exam: total number of bony enlargements (calc) NO P02FAMHXKR Mother, father, sister, or brother (blood relative) had knee repl surgery where all/part of knee replaced (used for study eligibility) NO P02ACTRISK Engage in at least one frequent knee bending activity (calc, used for study eligibility initially) NO V00PASE Physical Activity Scale for the Elderly (PASE) score (calc) NO P01INJR Right knee, ever injured badly enough to limit ability to walk for at least two days YES P01INJL Left knee, ever injured badly enough to limit ability to walk for at least two days YES P02KSURG Either knee, history of knee surgery (incl. arthroscopy, ligament repair, meniscectomy; used for study elig.) NO P02IKPRISK Either knee symptom status at IEI (calc, used for study eligibility) NO V00WOMKPR Right knee: WOMAC Pain Score (calc) YES V00KOOSKPR Right knee: KOOS Pain Score (calc) YES V00WOMSTFR Right knee: WOMAC Stiffness Score (calc) YES V00KOOSYMR Right knee: KOOS Symptoms Score (calc) YES V00WOMADLR Right knee: WOMAC Disability Score (calc) YES V00WOMTSR Right knee: WOMAC Total Score (calc) YES V00WOMKPL Left knee: WOMAC Pain Score (calc) YES V00KOOSKPL Left knee: KOOS Pain Score (calc) YES V00WOMSTFL Left knee: WOMAC Stiffness Score (calc) YES V00KOOSYML Left knee: KOOS Symptoms Score (calc) YES V00WOMADLL Left knee: WOMAC Disability Score (calc) YES V00WOMTSL Left knee: WOMAC Total Score (calc) YES

WOMAC, Western Ontario and McMaster Universities Osteoarthritis Index; KOOS, Knee injury and Osteoarthritis Outcome Score.

Camacho-Encina M, et al. Ann Rheum Dis 2019; 0:1699ÿý1705. doi: 10.1136/annrheumdis-2019-215325 Supplementary material Ann Rheum Dis

Supplementary Table S3. Median intensity through all the pooled sera, and mean and SD for the incident and not-incident groups, obtained for each protein in the discovery phase of this study. Data are expressed in arbitrary units (a.u.) of absorbance. Not-Incident All pooled Incident group group samples (n=20) (n=10) (n=10) PROTEIN Median Mean SD Mean SD ZNF558 5.37 0.21 0.08 0.23 0.07 TOB2 5.02 0.28 0.07 0.32 0.08 GNA13 4.97 1.66 0.76 1.88 0.71 AP3S1 4.95 0.49 0.22 0.72 0.26 TFRC 4.94 1.69 0.44 1.58 0.71 PDIA3 4.38 0.59 0.18 0.55 0.25 EBNA 4.24 0.08 0.05 0.12 0.08 CAPN10 4.11 1.11 0.22 0.99 0.12 L10 4.10 1.45 0.28 1.46 0.22 CYP19A1 3.93 2.06 0.43 2.07 0.33 NNMT 3.90 1.90 0.51 1.89 0.40 HOXA5 3.89 1.92 0.55 1.81 0.41 DAPP1 3.88 0.37 0.29 0.24 0.12 FOSL1 3.76 0.46 0.11 0.38 0.13 ARHGDIB 3.58 0.14 0.05 0.16 0.12 ATP1A1 3.57 2.19 0.53 1.88 0.83 NTSR2 3.47 0.90 0.31 0.82 0.38 L11 3.45 0.77 0.30 0.72 0.41 EIF3E 3.41 2.03 0.58 1.85 0.81 HLA-DQB1 3.41 0.53 0.20 0.45 0.28 GSTM3 3.40 1.92 0.38 1.75 0.33 CBX5 3.39 1.53 0.25 1.47 0.36 BMP5 3.38 2.29 0.63 1.99 0.40 CHIC1 3.35 1.66 0.32 1.39 0.49 ZNF658 3.33 0.47 0.11 0.36 0.13 UBE2J1 3.31 0.46 0.20 0.68 0.27 SFTPD 3.28 1.46 0.34 1.88 0.80 LMO4 3.28 2.33 0.78 2.27 0.91 L9 3.25 1.13 0.27 1.03 0.36 EPHX1 3.25 0.30 0.15 0.35 0.20 SMO 3.22 1.60 0.91 2.12 0.82 GPR83 3.22 1.80 0.57 2.05 0.88 ANXA4 3.21 0.17 0.10 0.36 0.28 SLC6A19 3.21 1.71 0.43 1.63 0.89 GSTM4 3.20 0.11 0.08 0.08 0.07 PTTG1 3.17 0.72 0.26 0.58 0.18 RPL13 3.16 0.21 0.19 0.20 0.17 CYC1 3.16 0.78 0.42 0.63 0.38 TAOK3 3.15 2.30 0.74 2.38 0.88 CXADR 3.15 1.03 0.34 0.97 0.36 AMY2A 3.13 1.32 0.33 1.39 0.23 PAX6 3.10 1.76 0.50 1.66 0.24 OTX2 3.09 1.63 0.34 1.56 0.15 PYGB 3.08 0.21 0.09 0.14 0.09 NRIP1 3.04 0.14 0.11 0.15 0.11 LTA 3.03 1.27 0.29 1.18 0.35 ABCF2 2.98 0.20 0.09 0.20 0.11 TCL1A 2.98 1.06 0.25 0.98 0.36 SLC2A5 2.97 1.68 0.49 1.44 0.29

Camacho-Encina M, et al. Ann Rheum Dis 2019; 0:1699ÿý1705. doi: 10.1136/annrheumdis-2019-215325 Supplementary material Ann Rheum Dis

MAP3K14 2.97 0.94 0.16 0.84 0.40 PFKFB4 2.95 0.09 0.05 0.14 0.11 DCK 2.93 2.19 0.43 2.08 0.61 MPG 2.92 1.47 0.31 1.46 0.34 AKR1C1 2.92 1.69 0.40 1.59 0.22 CTSK 2.91 1.63 0.35 1.62 0.24 YIPF6 2.90 0.20 0.09 0.09 0.09 PIK3C3 2.88 0.20 0.10 0.10 0.13 RPL18 2.88 1.98 0.45 1.81 0.24 SLC1A6 2.87 2.44 0.63 2.22 0.44 TNNC1 2.87 1.54 0.38 1.42 0.35 TBC1D4 2.85 2.84 0.90 2.64 0.63 L12 2.84 2.83 1.18 3.44 1.61 CH25H 2.80 3.63 0.68 3.53 1.11 NF2 2.79 1.99 0.32 1.95 0.23 NUP133 2.79 1.24 0.31 1.27 0.41 SLC6A8 2.78 1.77 0.35 1.82 0.22 GDNF 2.78 1.92 0.40 1.96 0.49 NFKB1 2.77 2.14 0.43 2.18 0.31 MTHFD1 2.74 0.16 0.05 0.16 0.10 PRDM4 2.74 0.49 0.16 0.49 0.31 PPIB 2.73 1.21 0.26 1.12 0.36 FOS 2.72 1.64 0.30 1.63 0.37 PDE6B 2.72 1.10 0.23 0.98 0.23 OGG1 2.71 1.49 0.30 1.39 0.31 FRK 2.68 2.10 0.26 2.06 1.11 MAP1LC3B 2.67 4.44 0.63 3.78 1.33 TRIM11 2.66 2.22 0.62 2.15 0.18 CDC25C 2.66 1.83 0.46 1.81 0.38 TBC1D2B 2.64 0.99 0.20 0.94 0.33 TNNI3 2.63 2.58 0.46 2.53 0.41 CTNNA1 2.62 5.22 1.11 4.71 1.75 TCAP 2.62 5.11 1.18 4.79 1.51 DEPTOR 2.60 1.16 0.30 0.98 0.41 MMP9 2.59 1.65 0.40 1.42 0.41 USP1 2.58 2.74 0.37 3.09 0.49 KCNAB1 2.57 1.60 0.24 1.48 0.32 ARPC5 2.57 4.17 0.70 3.63 1.30 PSMC2 2.57 1.90 0.39 1.87 0.28 DEFB130 2.57 2.04 0.42 2.07 0.26 CDC42 2.56 1.19 0.15 1.10 0.37 CCL11 2.55 2.11 0.53 2.32 0.54 PABPC1 2.55 1.09 0.18 1.00 0.34 DLK1 2.55 1.60 0.30 1.56 0.20 HMGB2 2.54 2.67 0.54 2.44 0.70 MAT2B 2.53 1.65 0.30 1.54 0.31 CCNH 2.53 2.43 0.68 2.37 0.51 IL10RA 2.53 1.59 0.23 1.47 0.29 NSL1 2.52 2.66 0.52 2.76 0.62 SH2D1A 2.52 5.34 1.10 4.54 1.27 STRADB 2.51 1.45 0.25 1.41 0.46 ETV3 2.51 1.77 0.22 1.66 0.55 PPM1A 2.49 1.98 0.42 1.94 0.31 CA2 2.48 0.86 0.17 0.74 0.30 TNNI1 2.47 0.82 0.15 0.69 0.23 APOA2 2.46 2.97 0.56 2.61 0.46 LAMC3 2.45 2.55 0.65 2.29 0.52 NPBWR2 2.45 0.92 0.16 0.90 0.28

Camacho-Encina M, et al. Ann Rheum Dis 2019; 0:1699ÿý1705. doi: 10.1136/annrheumdis-2019-215325 Supplementary material Ann Rheum Dis

RHOD 2.44 1.89 0.33 1.80 0.28 B3GNT7 2.42 2.19 0.32 1.86 0.24 GSTT2 2.42 3.37 0.42 3.05 1.10 NKX3-2 2.42 0.96 0.15 1.00 0.46 TMEM126A 2.41 2.13 0.50 1.75 0.20 SLC5A1 2.41 4.01 2.06 2.80 0.64 LHX2 2.40 0.79 0.22 0.58 0.17 SNRPA1 2.40 1.21 0.17 1.15 0.20 PPP3CA 2.40 1.63 0.20 1.59 0.29 LIFR 2.39 2.69 0.35 2.44 0.39 P3H3 2.39 1.48 0.26 1.38 0.22 BRF2 2.38 1.70 0.29 1.80 0.13 RUVBL1 2.37 0.93 0.10 0.87 0.31 IL6R 2.37 1.28 0.17 1.25 0.48 PSMB5 2.36 2.91 0.42 2.78 0.55 ULK4 2.36 0.68 0.22 0.78 0.31 PAX2 2.36 1.56 0.47 1.44 0.31 RPS4Y1 2.35 1.93 0.31 1.89 0.27 ANAPC2 2.34 1.07 0.21 1.00 0.35 PRH2 2.34 2.08 0.51 1.95 0.24 RPS9 2.33 2.55 0.51 2.25 0.42 PLD2 2.33 1.79 0.30 1.50 0.38 SIGIRR 2.33 3.63 0.65 3.14 0.71 ZNF473 2.33 2.67 0.59 2.13 0.48 KIR3DL1 2.32 3.25 0.51 3.89 1.11 GNG11 2.32 1.89 0.20 1.72 0.30 SF3B4 2.30 1.92 0.25 1.69 0.27 ACAA1 2.30 1.90 0.41 1.69 0.27 OR51B6 2.29 3.05 0.97 2.77 0.82 TRPV1 2.29 4.37 0.83 3.50 0.98 TBCD 2.28 1.24 0.15 1.06 0.27 SELL 2.28 2.39 0.40 2.18 0.33 GALNT6 2.27 2.35 0.39 1.98 0.35 L8 2.27 2.00 0.34 1.99 0.25 TOB1 2.27 1.43 0.18 1.31 0.45 TFAP2E 2.27 2.23 0.31 2.33 0.47 PMCH 2.26 0.79 0.19 0.67 0.21 TCF12 2.26 1.81 0.32 1.75 0.35 PSMA4 2.25 2.17 0.36 1.92 0.37 LRRTM4 2.25 2.19 0.48 2.00 0.30 SPOP 2.24 0.67 0.13 0.54 0.15 TUBGCP3 2.24 2.49 0.40 2.16 0.44 ZNF426 2.24 2.33 0.40 1.95 0.27 ZNF713 2.23 2.82 0.47 2.24 0.35 FHL2 2.23 2.83 0.52 1.99 0.63 APOE 2.23 2.08 0.56 1.63 0.50 ZNF496 2.22 0.07 0.04 0.02 0.02 SH3GL2 2.22 1.51 0.40 1.45 0.52 GFI1 2.22 1.66 0.39 1.60 0.66 GGT1 2.22 0.77 0.13 0.67 0.21 NAT8B 2.22 2.69 0.65 2.60 1.24 LAMP2 2.22 2.95 0.56 2.79 1.37 FGD2 2.22 0.44 0.10 0.49 0.20 MYBL2 2.21 2.57 0.66 2.51 0.93 TTLL7 2.20 1.82 0.53 1.82 0.63 MAT1A 2.20 1.92 0.55 1.80 0.70 TUBB2B 2.20 1.40 0.37 1.54 0.52 C1QBP 2.19 2.26 0.55 2.24 0.76

Camacho-Encina M, et al. Ann Rheum Dis 2019; 0:1699ÿý1705. doi: 10.1136/annrheumdis-2019-215325 Supplementary material Ann Rheum Dis

SQSTM1 2.19 0.91 0.29 0.81 0.27 RASSF5 2.18 0.35 0.14 0.33 0.17 PCDHGC3 2.18 0.30 0.15 0.28 0.15 TNFRSF21 2.18 0.67 0.25 0.53 0.24 DPAGT1 2.17 0.15 0.10 0.15 0.15 MCFD2 2.17 0.13 0.09 0.06 0.08 PEA15 2.17 0.09 0.07 0.09 0.07 SPRY2 2.16 1.92 0.34 1.96 0.20 ARHGAP4 2.16 1.95 0.29 1.98 0.27 OGN 2.16 1.09 0.20 1.08 0.26 SLC1A4 2.16 1.41 0.26 1.47 0.19 E4F1 2.15 0.27 0.11 0.25 0.11 KLK2 2.15 0.37 0.11 0.25 0.11 UROD 2.14 0.15 0.08 0.22 0.14 D2HGDH 2.14 0.75 0.15 0.63 0.18 ARMCX4 2.14 1.10 0.16 1.14 0.23 IL11RA 2.14 1.01 0.18 1.02 0.29 NAT9 2.14 0.96 0.16 0.98 0.28 TUBG1 2.13 2.07 0.41 1.94 0.41 RPS8 2.13 2.91 0.80 3.42 0.84 AQP2 2.13 0.12 0.06 0.15 0.10 PPP1R7 2.12 2.12 0.38 2.22 0.25 GRP 2.11 3.33 0.77 3.42 0.84 CBFA2T3 2.11 1.50 0.23 1.53 0.18 UBE2V2 2.11 2.07 0.53 1.96 0.55 KLK1 2.10 0.15 0.07 0.10 0.07 RGS21 2.10 0.22 0.15 0.21 0.16 FBXL3 2.10 0.83 0.18 0.65 0.22 ITGB7 2.10 1.20 0.24 1.11 0.32 HS3ST1 2.10 1.23 0.35 1.04 0.39 CENPJ 2.10 1.56 0.42 1.36 0.36 ADGRL4 2.09 5.57 1.41 4.46 1.07 RFFL 2.09 0.21 0.07 0.17 0.07 GUCY2D 2.09 0.15 0.11 0.16 0.10 SLC22A8 2.08 1.82 0.41 1.66 0.21 ATP4B 2.08 1.90 0.55 2.06 0.52 GTF2H4 2.08 2.26 0.45 2.17 0.22 SKIV2L 2.08 2.41 0.36 2.29 0.44 PSME2 2.07 1.19 0.44 1.36 0.54 RCHY1 2.06 0.78 0.32 0.79 0.30 ZNF816-ZNF32 2.06 1.50 0.30 1.46 0.15 FKBP3 2.06 1.48 0.30 1.45 0.12 IRF9 2.05 1.87 0.40 1.80 0.27 EPHA8 2.05 1.79 0.42 1.73 0.19 UGDH 2.05 1.69 0.33 1.60 0.13 PARD6B 2.05 0.15 0.06 0.14 0.07 CA7 2.04 0.30 0.19 0.34 0.20 GLYATL2 2.04 1.36 0.36 1.33 0.55 ITPK1 2.04 1.45 0.27 1.44 0.20 HOXB13 2.04 1.56 0.32 1.56 0.25 SLC7A9 2.04 0.93 0.12 0.82 0.30 SKAP2 2.04 0.45 0.23 0.59 0.28 HDAC11 2.03 1.07 0.31 0.83 0.31 ATG3 2.03 2.69 0.86 2.29 0.48 MRPS35 2.03 1.66 0.41 1.49 0.10 SORD 2.03 2.09 0.64 1.77 0.19 OR5P3 2.03 1.83 0.54 1.50 0.37 ST3GAL1 2.03 1.76 0.22 1.62 0.31

Camacho-Encina M, et al. Ann Rheum Dis 2019; 0:1699ÿý1705. doi: 10.1136/annrheumdis-2019-215325 Supplementary material Ann Rheum Dis

DOK2 2.03 1.82 0.32 1.64 0.26 BAZ2B 2.03 0.30 0.14 0.28 0.14 UBE2A 2.02 1.10 0.20 0.87 0.21 UGT1A7 2.02 1.77 0.28 1.85 0.24 PRLR 2.02 1.86 0.39 1.99 0.27 GNAT2 2.02 1.48 0.28 1.40 0.16 KLF8 2.02 0.47 0.07 0.40 0.11 CYP20A1 2.01 1.20 0.15 1.14 0.24 ZNF184 2.01 1.29 0.32 1.10 0.29 MVK 2.01 1.46 0.23 1.41 0.16 CSNK2B 2.01 2.14 0.48 2.06 0.26 NKX2-5 2.00 1.54 0.25 1.54 0.13 KRT17 2.00 1.76 0.26 1.58 0.31 TGOLN2 2.00 0.61 0.23 0.68 0.26 UBA3 2.00 0.48 0.20 0.60 0.33 CX3CR1 2.00 0.97 0.18 1.02 0.24 F13B 1.99 0.74 0.10 0.74 0.30 RAB1B 1.99 2.17 0.41 2.13 0.27 PRKAG2 1.99 2.06 0.48 2.00 0.19 KIF20A 1.99 0.20 0.08 0.18 0.10 CDCA7L 1.99 0.20 0.11 0.15 0.08 MSX2 1.99 1.58 0.40 1.48 0.19 CCDC180 1.99 1.61 0.44 1.37 0.24 DEFB112 1.98 2.38 0.80 2.31 0.46 AP2M1 1.98 2.28 0.41 2.08 0.50 RIN1 1.98 2.23 0.44 2.15 0.34 CES1 1.98 0.80 0.43 0.72 0.37 P2RX3 1.98 1.42 0.22 1.40 0.15 CLDN8 1.97 1.71 0.31 1.64 0.27 VTA1 1.97 1.42 0.18 1.39 0.15 CYP2J2 1.97 1.52 0.22 1.40 0.17 ZCCHC12 1.97 1.78 0.25 1.70 0.26 SGK1 1.97 0.36 0.08 0.34 0.10 ESRRB 1.97 0.15 0.04 0.17 0.12 CYP4B1 1.96 1.44 0.21 1.31 0.18 OR4E2 1.95 1.75 0.34 1.69 0.21 OLR1 1.95 1.09 0.21 1.01 0.17 NPS 1.95 1.79 0.38 1.96 0.33 ZNF566 1.95 1.78 0.33 1.57 0.42 TAS1R2 1.95 2.97 0.58 2.86 0.80 HSP90AB1 1.94 1.73 0.41 1.55 0.23 DUSP13 1.94 1.00 0.16 0.96 0.29 DUSP22 1.94 1.44 0.19 1.48 0.14 COX6A2 1.94 2.00 0.40 1.96 0.24 PHB2 1.94 1.71 0.21 1.63 0.17 NR0B2 1.94 1.65 0.30 1.49 0.26 CETP 1.93 1.69 0.37 1.50 0.26 KLK6 1.93 1.77 0.44 1.29 0.30 IP6K2 1.93 2.47 0.84 2.30 0.48 UGP2 1.93 1.40 0.24 1.33 0.23 COMP 1.93 1.25 0.25 1.13 0.33 MLNR 1.93 1.27 0.22 1.12 0.31 HK3 1.93 1.47 0.22 1.32 0.17 CCL27 1.92 1.45 0.24 1.32 0.29 STMN4 1.92 1.37 0.22 1.31 0.39 HMG20B 1.92 1.07 0.13 0.94 0.16 PF4V1 1.92 0.50 0.10 0.41 0.12 CTSD 1.92 0.95 0.06 0.86 0.26

Camacho-Encina M, et al. Ann Rheum Dis 2019; 0:1699ÿý1705. doi: 10.1136/annrheumdis-2019-215325 Supplementary material Ann Rheum Dis

CAPN12 1.92 0.69 0.10 0.64 0.17 COX10 1.92 1.56 0.16 1.42 0.22 IDNK 1.91 3.31 0.61 3.14 0.85 RPS19 1.91 0.99 0.15 0.92 0.30 GJD3 1.91 1.24 0.13 1.13 0.23 NANOG 1.91 1.21 0.22 1.17 0.26 ARAF 1.91 0.91 0.46 0.86 0.42 MAPKAP1 1.90 0.68 0.11 0.65 0.29 ZNF19 1.90 0.87 0.14 0.86 0.36 XAB2 1.90 2.26 0.51 1.93 0.41 ARL1 1.90 1.18 0.15 1.06 0.30 TNFSF12-TNFS 1.89 0.74 0.15 0.62 0.16 TIMM21 1.89 1.56 0.18 1.44 0.24 GTF2H3 1.89 0.58 0.08 0.49 0.24 COL2A1 1.89 0.45 0.08 0.39 0.12 POMC 1.89 3.53 0.58 3.42 1.21 ORC6 1.89 1.64 0.40 1.28 0.33 TBPL1 1.88 1.94 0.20 1.78 0.30 GSS 1.88 1.88 0.24 1.69 0.32 CHST10 1.88 1.56 0.17 1.24 0.29 AP1S2 1.88 2.74 0.39 2.41 0.51 CLU 1.87 2.17 0.40 1.63 0.45 RPS7 1.87 1.55 0.33 1.49 0.37 SYN1 1.87 1.09 0.10 1.00 0.26 CARKD 1.87 1.51 0.14 1.31 0.27 YEATS4 1.86 1.17 0.09 0.91 0.17 NMS 1.86 1.08 0.11 0.83 0.21 CTAG1A 1.86 1.90 0.23 1.55 0.24 SOX2 1.86 1.23 0.18 1.23 0.22 ZBTB16 1.86 0.89 0.14 0.75 0.20 POGLUT1 1.86 1.37 0.14 1.33 0.31 DEFB106B 1.86 0.86 0.13 0.71 0.23 RBM17 1.86 1.17 0.18 0.99 0.30 TFB1M 1.86 0.84 0.20 0.65 0.29 SLC36A1 1.86 1.01 0.19 1.10 0.22 ERCC1 1.86 0.05 0.03 0.03 0.02 VDR 1.86 1.65 0.16 1.44 0.26 ZNF510 1.86 1.90 0.20 1.60 0.31 DUSP14 1.85 1.58 0.19 1.29 0.38 MIB2 1.85 1.52 0.21 1.22 0.31 PARS2 1.84 1.82 0.27 1.79 0.27 SCRIB 1.84 2.33 0.60 2.06 0.39 LIF 1.84 1.24 0.38 1.28 0.54 SNTA1 1.84 0.56 0.17 0.47 0.19 ESAM 1.84 0.76 0.16 0.63 0.22 RPS10-NUDT3 1.83 0.44 0.11 0.49 0.22 MYL2 1.83 0.30 0.17 0.29 0.16 FBXW11 1.83 0.41 0.17 0.40 0.28 DNTT 1.83 0.05 0.05 0.06 0.07 FKBP14 1.82 1.94 0.36 1.80 0.30 RBM42 1.82 1.28 0.18 1.35 0.17 KRTAP2-4 1.82 1.36 0.19 1.45 0.07 CDC73 1.82 2.06 0.28 1.99 0.15 PON2 1.82 1.86 0.28 1.78 0.20 MKNK1 1.82 2.37 0.25 2.34 0.20 NRN1L 1.81 0.16 0.05 0.19 0.10 STAR 1.81 1.29 0.25 1.39 0.57 GSTA4 1.81 1.62 0.44 1.47 0.60

Camacho-Encina M, et al. Ann Rheum Dis 2019; 0:1699ÿý1705. doi: 10.1136/annrheumdis-2019-215325 Supplementary material Ann Rheum Dis

PSMB4 1.81 0.16 0.06 0.22 0.10 GYG2 1.81 0.41 0.17 0.48 0.20 DDOST 1.81 0.36 0.15 0.41 0.16 JAM2 1.81 2.15 0.53 2.09 0.81 SUMF2 1.81 1.40 0.23 1.27 0.11 MAPKAPK3 1.81 1.97 0.36 1.85 0.27 ZNF480 1.80 1.97 0.19 1.85 0.21 TUBB8 1.80 1.66 0.19 1.71 0.13 PLCG2 1.80 2.22 0.53 2.07 0.39 GTF2E1 1.80 2.30 0.46 1.98 0.14 CHN1 1.80 3.49 0.74 3.17 0.38 YIF1B 1.80 0.47 0.18 0.47 0.20 ORC5 1.79 0.45 0.26 0.41 0.26 RPS16 1.79 1.57 0.34 1.49 0.56 NPY 1.79 1.13 0.09 1.12 0.29 PTPRA 1.79 0.06 0.04 0.08 0.07 IGFBP6 1.79 0.05 0.04 0.06 0.05 PFN1 1.79 0.50 0.22 0.55 0.24 RHOG 1.79 0.21 0.10 0.31 0.16 DUT 1.79 0.66 0.22 0.78 0.29 GABARAPL2 1.79 0.15 0.24 0.14 0.10 OPRK1 1.79 1.60 0.21 1.52 0.17 NKAIN1 1.79 0.08 0.06 0.04 0.05 RBMS1 1.78 0.06 0.09 0.02 0.04 DGKA 1.78 0.10 0.07 0.11 0.08 HLA-DRB3 1.78 1.12 0.62 1.14 0.68 HNF1A 1.78 0.31 0.23 0.17 0.21 CASP9 1.78 0.62 0.15 0.70 0.33 SHMT1 1.78 1.54 0.22 1.38 0.21 HCN3 1.77 3.62 0.57 3.21 0.85 GCNT3 1.77 2.99 0.63 2.47 0.64 AGT 1.77 1.77 0.33 1.59 0.34 ZNF383 1.77 1.86 0.32 1.65 0.24 SULF1 1.77 0.17 0.05 0.13 0.10 PEX11A 1.77 0.20 0.08 0.16 0.14 KRT2 1.76 1.69 0.20 1.67 0.20 TNFRSF10A 1.76 1.16 0.15 1.16 0.25 ATP6V1C1 1.75 1.56 0.27 1.56 0.22 KREMEN2 1.75 1.31 0.20 1.36 0.11 DTYMK 1.75 0.78 0.44 0.56 0.18 IL24 1.75 0.14 0.19 0.15 0.10 NKX2-1 1.75 0.24 0.14 0.33 0.20 SPRY1 1.75 1.41 0.20 1.30 0.15 MAP2K3 1.75 3.20 0.54 3.42 0.80 C4BPA 1.75 1.75 0.40 1.68 0.43 ZNF18 1.75 3.37 0.61 3.45 0.89 PPP2R1A 1.75 1.24 0.18 1.31 0.31 CXCL14 1.75 0.10 0.06 0.11 0.09 GJA8 1.74 1.57 0.13 1.49 0.23 SLC22A5 1.74 1.21 0.20 1.11 0.26 KLF9 1.74 2.28 0.43 2.09 0.43 HK2 1.74 2.38 0.74 2.07 0.26 FOLR3 1.74 2.83 0.50 2.51 0.69 PDGFRL 1.74 2.15 0.34 1.92 0.35 SNCA 1.73 1.61 0.34 1.49 0.20 TRAF2 1.73 2.13 0.46 1.58 0.33 GHSR 1.73 1.18 0.45 0.93 0.26 DUSP15 1.73 1.37 0.52 1.21 0.19

Camacho-Encina M, et al. Ann Rheum Dis 2019; 0:1699ÿý1705. doi: 10.1136/annrheumdis-2019-215325 Supplementary material Ann Rheum Dis

GJB2 1.73 1.88 0.25 1.86 0.33 AADAT 1.73 1.17 0.29 1.10 0.42 EEF1G 1.73 1.69 0.30 1.72 0.26 PEMT 1.72 1.29 0.15 1.33 0.12 CYP26A1 1.72 1.50 0.17 1.65 0.17 EHD2 1.72 1.19 0.18 1.19 0.16 RAMP2 1.72 1.43 0.23 1.56 0.08 AK8 1.72 2.04 0.27 1.96 0.35 MED20 1.72 1.39 0.16 1.32 0.15 RNF41 1.72 1.35 0.18 1.25 0.14 SNAP25 1.72 1.74 0.25 1.84 0.19 GSN 1.71 0.72 0.12 0.69 0.25 ZNF691 1.71 1.73 0.37 1.77 0.32 CFB 1.71 2.42 0.32 2.25 0.40 TAF12 1.71 1.46 0.19 1.43 0.12 HDAC3 1.71 2.38 0.37 2.16 0.35 LSS 1.71 1.68 0.28 1.57 0.25 L7 1.71 0.91 0.16 0.72 0.16 OR52M1 1.70 1.32 0.40 1.02 0.24 12/01/2015 1.70 2.53 0.43 2.72 0.54 GORASP1 1.70 2.55 0.41 2.52 0.30 FXN 1.69 2.29 0.40 2.20 0.39 IFNA21 1.69 2.37 0.38 2.04 0.35 ITGB1 1.69 1.36 0.46 1.08 0.33 PROK1 1.69 2.53 0.77 2.13 0.25 HTR2B 1.69 0.39 0.07 0.37 0.10 C8orf86 1.69 1.16 0.13 1.13 0.18 MDH2 1.68 1.70 0.16 1.80 0.19 PAX8 1.68 1.15 0.18 1.05 0.14 TKT 1.68 1.40 0.21 1.46 0.23 SIRT6 1.68 1.84 0.32 1.88 0.28 NEU1 1.68 5.39 1.38 5.35 1.44 MOGAT1 1.67 2.02 0.20 2.01 0.21 CSH1 1.67 3.12 0.25 3.30 0.79 PPP1R14B 1.67 2.01 0.25 1.98 0.35 RPS3 1.67 1.86 0.30 1.90 0.20 STEAP4 1.67 1.15 0.16 1.01 0.33 SNAI2 1.67 0.64 0.11 0.57 0.26 SLC25A6 1.67 2.87 0.55 2.67 0.69 ILK 1.67 1.84 0.27 1.78 0.31 RPL9 1.66 1.85 0.21 1.86 0.15 OR2M2 1.66 1.21 0.14 1.11 0.18 DCTN2 1.66 1.59 0.20 1.50 0.24 SSTR1 1.66 1.01 0.16 0.91 0.20 GGT5 1.65 1.55 0.18 1.42 0.22 ZNF677 1.65 1.54 0.31 1.28 0.29 GAGE12B 1.65 2.81 0.47 2.51 0.47 FARS2 1.65 1.14 0.13 1.02 0.21 RPRM 1.65 2.50 0.43 2.28 0.34 ARRB2 1.65 2.03 0.31 1.93 0.32 KRAS 1.65 2.60 0.48 2.25 0.82 UBE2S 1.65 1.09 0.15 1.01 0.24 CD40 1.65 2.15 0.37 2.00 0.33 SLC25A16 1.65 0.69 0.09 0.64 0.13 GSTP1 1.64 2.11 0.28 2.11 0.34 GABRB1 1.64 1.93 0.34 1.79 0.30 DLX1 1.64 2.38 0.29 2.14 0.28 TRIP13 1.64 1.90 0.21 1.83 0.16

Camacho-Encina M, et al. Ann Rheum Dis 2019; 0:1699ÿý1705. doi: 10.1136/annrheumdis-2019-215325 Supplementary material Ann Rheum Dis

CPSF4 1.64 1.37 0.20 1.28 0.19 UROS 1.64 1.43 0.17 1.28 0.23 RXFP2 1.64 1.41 0.19 1.44 0.25 SCTR 1.64 1.74 0.32 1.48 0.27 BAAT 1.64 2.46 0.41 2.35 0.38 CSGALNACT2 1.64 1.87 0.49 2.04 0.63 CD22 1.64 2.12 0.30 1.99 0.32 GABRA5 1.64 1.55 0.19 1.56 0.29 PCNA 1.64 1.67 0.11 1.53 0.17 CCDC11 1.63 1.50 0.12 1.38 0.13 SAFB 1.63 1.14 0.14 1.10 0.22 STBD1 1.63 1.90 0.26 1.89 0.26 CAV1 1.63 1.89 0.27 1.82 0.36 MSI2 1.63 1.54 0.23 1.33 0.28 CPSF1 1.63 0.97 0.14 0.74 0.22 VDAC1 1.62 2.43 0.56 2.05 0.25 PITPNA 1.62 2.31 0.38 2.06 0.32 HNMT 1.62 2.10 0.29 1.84 0.22 ARHGAP9 1.62 1.69 0.22 1.45 0.20 MVD 1.61 1.73 0.22 1.59 0.26 SULT1A3 1.61 1.97 0.23 1.75 0.32 NAA20 1.61 2.40 0.40 1.95 0.29 S1PR5 1.61 1.87 0.16 1.74 0.20 ZNF597 1.61 2.12 0.19 1.91 0.22 RBBP4 1.61 1.46 0.14 1.22 0.26 CXCL11 1.61 1.64 0.13 1.54 0.27 MAS1L 1.61 1.67 0.19 1.36 0.28 FBXO17 1.61 2.19 0.31 1.88 0.23 GAPDHS 1.60 0.06 0.02 0.04 0.03 AHCY 1.60 1.82 0.23 1.60 0.23 RGS7 1.60 1.97 0.17 1.84 0.22 PRPF4 1.60 1.34 0.14 1.22 0.16 VPS4B 1.60 1.51 0.21 1.34 0.19 KIR2DL4 1.60 1.90 0.30 1.61 0.22 AHSG 1.60 1.13 0.24 0.82 0.26 STUB1 1.60 1.93 0.18 1.84 0.17 SPCS3 1.59 1.27 0.13 1.03 0.32 OR2M4 1.59 2.10 0.25 1.88 0.22 MX2 1.59 1.36 0.32 1.02 0.39 SNAPC2 1.59 2.83 0.45 2.37 0.39 AREG 1.59 2.85 0.49 2.30 0.49 STX12 1.59 1.21 0.24 1.19 0.46 ARSH 1.59 0.92 0.20 0.82 0.27 DHFRL1 1.59 1.61 0.35 1.43 0.63 RIPK3 1.59 0.43 0.16 0.46 0.21 MIS12 1.59 0.12 0.05 0.11 0.08 IGFBP4 1.59 0.43 0.14 0.41 0.15 BAK1 1.58 0.33 0.11 0.40 0.17 ZNF583 1.58 1.06 0.28 1.00 0.29 POLR2E 1.58 1.13 0.19 0.99 0.36 OAZ1 1.58 0.81 0.15 0.76 0.20 GRAP2 1.58 0.79 0.17 0.75 0.25 RAG2 1.58 1.74 0.48 1.89 0.69 LHX1 1.58 0.60 0.35 0.62 0.37 LZTS1 1.58 2.03 0.48 2.16 0.83 AKR1C4 1.58 0.23 0.07 0.24 0.11 HTR1B 1.58 0.21 0.07 0.18 0.10 SMARCD1 1.58 0.32 0.28 0.39 0.39

Camacho-Encina M, et al. Ann Rheum Dis 2019; 0:1699ÿý1705. doi: 10.1136/annrheumdis-2019-215325 Supplementary material Ann Rheum Dis

BRD4 1.58 0.10 0.07 0.14 0.12 CACNG4 1.58 0.06 0.06 0.06 0.08 TIMP1 1.57 0.69 0.25 0.65 0.30 LAMTOR3 1.57 3.84 0.82 2.85 1.15 GPR4 1.57 0.19 0.09 0.14 0.09 PHF5A 1.57 3.15 0.58 2.79 0.56 EIF3I 1.57 3.27 0.54 3.03 0.91 GMPPA 1.57 3.09 0.48 2.81 0.55 ZNF528 1.57 0.14 0.05 0.12 0.07 ANTXR1 1.57 0.13 0.05 0.08 0.06 PTS 1.57 0.18 0.11 0.20 0.11 SLC30A7 1.56 1.25 0.14 1.21 0.19 SOCS1 1.56 0.79 0.10 0.76 0.24 KCNK1 1.56 2.12 0.39 2.02 0.54 MGAT1 1.56 3.84 0.61 3.94 1.43 PGLS 1.56 0.29 0.10 0.41 0.19 MPI 1.56 1.67 0.17 1.71 0.18 CASP2 1.56 2.92 0.54 2.85 0.70 ABCB6 1.56 0.82 0.31 0.74 0.35 TRIM32 1.56 0.35 0.27 0.15 0.08 TAAR2 1.56 0.09 0.05 0.07 0.07 PCOLCE2 1.56 1.50 0.21 1.34 0.24 CRLF1 1.55 1.58 0.36 1.54 0.25 KCNG3 1.55 0.83 0.13 0.76 0.20 HLA-DPB1 1.55 1.65 0.38 1.50 0.11 MPL 1.55 3.06 1.09 3.01 1.03 SNIP1 1.55 0.39 0.23 0.39 0.26 P2RY13 1.55 0.22 0.13 0.28 0.17 CLDN3 1.55 1.49 0.36 1.36 0.25 DNM1L 1.55 1.42 0.23 1.38 0.12 NID2 1.55 1.20 0.17 1.13 0.26 ALG3 1.55 2.86 0.55 2.58 0.36 RAD9B 1.55 3.28 0.68 2.91 0.89 SOCS4 1.55 1.51 0.48 1.79 0.89 GNB4 1.54 2.23 0.44 2.22 0.52 PLXNA4 1.54 1.04 0.15 1.04 0.11 CDC6 1.54 0.15 0.05 0.17 0.10 CTBP1 1.54 1.12 0.20 1.16 0.15 SURF1 1.54 0.16 0.05 0.11 0.10 NAE1 1.54 0.19 0.16 0.27 0.23 FTH1 1.54 1.10 0.12 1.06 0.27 SLC39A8 1.53 1.02 0.18 1.05 0.14 CCNG2 1.53 0.63 0.12 0.63 0.18 PDHB 1.53 2.23 0.21 2.25 0.31 CRABP1 1.53 2.08 0.35 1.89 0.56 OPLAH 1.53 3.67 0.68 3.85 1.50 CXCL10 1.53 1.40 0.39 1.41 0.49 IFT57 1.53 1.39 0.21 1.43 0.16 SIRT7 1.53 1.55 0.29 1.36 0.47 TNNC2 1.53 1.32 0.22 1.34 0.13 GFRA1 1.53 1.69 0.40 1.61 0.17 PCMT1 1.53 0.72 0.17 0.49 0.20 SSTR5 1.53 2.81 0.48 2.54 0.44 ID2 1.53 2.42 0.48 2.21 0.56 ARRB1 1.53 1.89 0.29 1.77 0.26 FBXW12 1.52 1.97 0.31 1.90 0.43 ATP2A1 1.52 0.41 0.09 0.41 0.14 SLC30A8 1.52 1.47 0.23 1.54 0.10

Camacho-Encina M, et al. Ann Rheum Dis 2019; 0:1699ÿý1705. doi: 10.1136/annrheumdis-2019-215325 Supplementary material Ann Rheum Dis

A1BG 1.52 1.58 0.19 1.72 0.18 CDC26 1.52 0.28 0.06 0.27 0.09 ESRRG 1.52 1.18 0.14 1.15 0.09 CXCL1 1.52 1.54 0.19 1.53 0.21 PLA2G2A 1.51 1.48 0.18 1.52 0.14 ERAL1 1.51 2.07 0.39 2.09 0.25 TMEM43 1.51 2.02 0.37 2.04 0.23 UBE2D4 1.51 2.04 0.40 1.71 0.59 SLC2A7 1.51 1.58 0.37 1.70 0.52 SYT6 1.51 3.08 0.51 3.24 1.11 EIF5 1.50 0.53 0.10 0.52 0.17 HMGCL 1.50 1.22 0.13 1.29 0.18 MICALL1 1.50 1.48 0.17 1.78 0.33 RND3 1.50 1.54 0.25 1.54 0.16 TNF 1.50 0.29 0.04 0.26 0.10 ATP1A4 1.50 0.95 0.09 0.94 0.21 RGS11 1.50 0.71 0.08 0.68 0.20 ZNF85 1.50 1.63 0.32 1.57 0.24 SULT2A1 1.50 0.26 0.06 0.21 0.09 CCR9 1.50 2.34 0.59 2.20 0.22 NDUFA3 1.50 1.38 0.28 1.36 0.28 ACADL 1.50 1.72 0.23 1.86 0.34 LEFTY1 1.50 1.44 0.32 1.47 0.36 POU1F1 1.49 1.26 0.19 1.30 0.14 CHRNB1 1.49 0.79 0.12 0.75 0.24 IFITM2 1.49 1.63 0.27 1.54 0.12 ALOX15B 1.49 1.51 0.21 1.49 0.15 RBM33 1.49 1.77 0.29 1.80 0.21 CNR2 1.49 0.28 0.06 0.29 0.13 OR2L13 1.49 1.36 0.20 1.31 0.11 PISD 1.49 1.75 0.36 1.85 0.35 CYP4X1 1.49 1.10 0.21 1.06 0.13 ZNF432 1.48 1.08 0.23 0.96 0.26 KRTAP19-7 1.48 0.49 0.32 0.67 0.48 FGFR1OP2 1.48 1.04 0.19 1.02 0.10 MYLIP 1.48 1.70 0.33 1.74 0.41 CYCS 1.48 1.34 0.21 1.49 0.20 SAE1 1.48 1.18 0.12 1.25 0.13 LGALS1 1.48 1.46 0.18 1.43 0.21 IL6 1.48 1.63 0.19 1.66 0.12 NPPB 1.48 1.56 0.14 1.51 0.10 ZNF671 1.48 1.62 0.20 1.66 0.13 SHC1 1.47 1.52 0.18 1.45 0.41 RGS1 1.47 2.36 0.46 2.55 0.72 ZNF562 1.47 1.88 0.42 1.73 0.16 VAT1L 1.47 1.95 0.54 1.60 0.21 RPL18A 1.47 1.13 0.22 1.04 0.33 UBE2Q2 1.47 1.01 0.15 0.93 0.21 AAK1 1.47 1.39 0.28 1.33 0.19 ID1 1.47 1.15 0.19 1.13 0.12 MCM7 1.47 1.46 0.23 1.36 0.15 ZFAND5 1.47 1.44 0.22 1.31 0.16 PSTPIP1 1.47 1.58 0.14 1.43 0.19 RAMP1 1.46 0.85 0.11 0.79 0.14 EXOSC3 1.46 1.64 0.19 1.58 0.21 DNAJB1 1.46 1.68 0.20 1.59 0.18 ETS2 1.46 0.68 0.08 0.62 0.11 BCL2L11 1.46 0.81 0.17 0.87 0.17

Camacho-Encina M, et al. Ann Rheum Dis 2019; 0:1699ÿý1705. doi: 10.1136/annrheumdis-2019-215325 Supplementary material Ann Rheum Dis

CTSC 1.46 1.73 0.28 1.66 0.12 CDKN2D 1.46 1.54 0.25 1.57 0.11 CAMP 1.46 0.86 0.14 0.86 0.21 TESK1 1.46 0.59 0.09 0.57 0.13 GPR161 1.46 0.60 0.11 0.58 0.11 ITGB6 1.46 0.97 0.15 0.96 0.11 HLA-A 1.46 1.39 0.16 1.44 0.21 AK1 1.46 0.66 0.07 0.56 0.13 CYP4F11 1.46 1.06 0.09 0.97 0.19 GRPEL2 1.46 0.46 0.07 0.42 0.10 GALNT4 1.46 1.77 0.18 1.69 0.27 SPATA6L 1.45 1.53 0.50 1.58 0.64 RGMA 1.45 0.55 0.10 0.48 0.09 HOXA10 1.45 1.01 0.19 0.83 0.15 DNAJB9 1.45 2.23 0.53 1.75 0.25 NMU 1.45 1.81 0.24 1.73 0.32 B3GNT2 1.45 1.88 0.26 1.81 0.36 LNX1 1.45 1.43 0.19 1.26 0.21 TECR 1.45 2.20 0.31 1.90 0.36 AMPD1 1.45 2.29 0.30 1.91 0.38 B3GALT4 1.45 1.78 0.30 1.42 0.15 DCAF7 1.45 1.56 0.14 1.38 0.16 IL13RA2 1.45 2.21 0.33 1.99 0.40 SLC25A20 1.44 1.81 0.17 1.62 0.27 NRBF2 1.44 1.67 0.22 1.31 0.36 SST 1.44 2.07 0.32 2.05 0.46 MAGT1 1.44 1.63 0.45 1.75 0.37 MAD2L2 1.44 1.41 0.15 1.35 0.19 OR5D14 1.44 1.25 0.16 1.19 0.15 P2RY6 1.44 1.71 0.19 1.59 0.20 PPBP 1.44 1.49 0.20 1.39 0.22 HSPA8 1.44 2.40 0.39 2.32 0.41 09/04/2015 1.44 2.16 0.33 1.78 0.37 CXCL6 1.44 0.06 0.03 0.04 0.03 09/02/2015 1.44 1.42 0.16 1.23 0.23 CFAP20 1.44 1.62 0.22 1.29 0.16 MATR3 1.44 1.50 0.31 1.20 0.24 ATP5G3 1.44 1.28 0.26 1.07 0.29 B4GAT1 1.44 1.76 0.28 1.41 0.30 QKI 1.44 1.24 0.19 1.16 0.19 PARPBP 1.43 1.22 0.27 1.28 0.51 LEF1 1.43 0.70 0.18 0.69 0.28 ZNF668 1.43 0.42 0.12 0.42 0.16 NEUROG3 1.43 0.32 0.09 0.41 0.18 AKR1C3 1.43 0.27 0.10 0.26 0.11 HLA-DOA 1.43 0.09 0.06 0.09 0.08 TEAD2 1.43 1.13 0.16 1.18 0.10 DEPDC7 1.43 1.40 0.13 1.26 0.17 GPATCH2 1.43 1.48 0.14 1.48 0.18 PDE6G 1.43 1.00 0.16 0.96 0.19 WWP2 1.43 1.32 0.18 1.39 0.11 NR5A1 1.42 1.50 0.27 1.48 0.21 GLRX 1.42 1.01 0.25 1.07 0.10 DCPS 1.42 1.15 0.22 1.25 0.48 DAD1 1.42 0.32 0.07 0.38 0.17 GIP 1.42 0.31 0.06 0.41 0.20 DENND1B 1.42 0.43 0.09 0.52 0.18 IL9 1.41 1.17 0.20 1.23 0.53

Camacho-Encina M, et al. Ann Rheum Dis 2019; 0:1699ÿý1705. doi: 10.1136/annrheumdis-2019-215325 Supplementary material Ann Rheum Dis

PTGDR2 1.41 0.98 0.14 1.02 0.13 EIF1 1.41 1.38 0.24 1.24 0.28 C5AR2 1.41 1.54 0.24 1.64 0.29 AGPAT3 1.41 1.57 0.23 1.58 0.22 PRMT1 1.41 1.25 0.19 1.29 0.11 EDEM1 1.41 2.03 0.25 1.75 0.22 CTSZ 1.41 1.77 1.10 1.50 0.49 IL13 1.41 0.08 0.07 0.10 0.07 GPC4 1.41 0.08 0.05 0.07 0.06 CENPQ 1.40 0.84 0.31 0.75 0.27 FOSB 1.40 1.36 0.22 1.31 0.15 FLI1 1.40 0.09 0.03 0.08 0.07 P2RX1 1.40 0.08 0.05 0.06 0.06 RAB8A 1.40 0.56 0.18 0.70 0.30 MANEA 1.40 0.25 0.14 0.36 0.18 NTF3 1.40 0.19 0.10 0.24 0.11 OPN3 1.40 0.82 0.80 0.84 0.78 CCL28 1.39 0.36 0.15 0.44 0.24 HLA-DOB 1.39 0.23 0.15 0.32 0.17 KIR2DL3 1.39 1.69 0.22 1.64 0.24 ARIH2 1.39 0.12 0.08 0.16 0.14 PYGO2 1.39 0.08 0.08 0.04 0.07 DEFB108B 1.38 0.11 0.09 0.04 0.08 HRAS 1.38 0.83 0.35 0.85 0.47 LPAR6 1.38 0.20 0.12 0.11 0.10 DIABLO 1.38 0.29 0.12 0.37 0.19 CCND2 1.38 0.43 0.18 0.48 0.27 CNN1 1.38 1.27 0.19 1.15 0.22 PSMA6 1.38 1.82 0.49 1.43 0.53 PCOLCE 1.38 3.11 0.41 2.85 0.88 CALCOCO2 1.38 1.60 0.23 1.35 0.23 OR7C2 1.38 1.27 0.19 1.15 0.14 PDGFB 1.38 0.10 0.06 0.18 0.12 SLC37A4 1.38 1.41 0.15 1.36 0.09 VPS25 1.38 2.30 0.43 2.16 0.69 MNDA 1.37 1.20 0.18 1.15 0.15 GPR135 1.37 0.72 0.13 0.72 0.15 TAF9B 1.37 1.25 0.23 1.23 0.10 PPA2 1.37 0.20 0.06 0.26 0.14 DAB2 1.37 1.05 0.47 1.00 0.45 PRKAR1A 1.37 2.96 0.73 2.99 0.93 BDH1 1.37 1.76 0.48 1.83 0.62 ITGB2 1.37 2.96 0.30 2.52 0.59 ARMC8 1.37 1.18 0.27 1.24 0.31 NDUFV1 1.36 0.14 0.06 0.07 0.07 SF1 1.36 0.15 0.08 0.13 0.11 WNT2 1.36 1.12 0.13 1.17 0.16 TUBB4B 1.36 1.22 0.14 1.29 0.16 RAD1 1.36 4.43 0.77 4.33 1.31 ADGRE5 1.36 1.03 0.21 0.94 0.25 TDO2 1.36 1.90 0.45 1.67 0.16 RASSF7 1.36 1.99 0.33 1.61 0.42 C6orf58 1.36 1.74 0.36 1.56 0.21 RAD51 1.36 0.25 0.07 0.25 0.08 GNB3 1.36 2.08 0.27 2.00 0.27 EIF4H 1.36 1.92 0.34 1.76 0.39 DEFB110 1.36 1.76 0.33 1.39 0.28 KCNQ2 1.35 2.01 0.31 1.99 0.49

Camacho-Encina M, et al. Ann Rheum Dis 2019; 0:1699ÿý1705. doi: 10.1136/annrheumdis-2019-215325 Supplementary material Ann Rheum Dis

NFYB 1.35 1.57 0.37 1.51 0.21 HDGF 1.35 0.93 0.12 1.01 0.10 C1QC 1.35 1.47 0.19 1.43 0.21 MTERF3 1.35 1.19 0.15 1.21 0.13 AKR1C2 1.35 1.12 0.22 1.17 0.07 QDPR 1.35 0.85 0.15 0.85 0.07 PAM16 1.35 0.82 0.19 0.85 0.10 PTGS1 1.35 2.27 0.33 2.14 0.35 BGN 1.35 1.36 0.17 1.34 0.27 CXCL17 1.35 1.37 0.17 1.36 0.13 TAF7 1.35 0.86 0.15 0.90 0.21 SERPINB2 1.35 2.24 0.26 2.30 0.55 CERS4 1.35 1.74 0.19 1.83 0.60 RRAS 1.35 2.05 0.21 2.07 0.63 PPIA 1.35 1.13 0.18 1.04 0.29 ENG 1.34 1.89 0.27 1.73 0.32 UBTD2 1.34 1.32 0.22 1.42 0.12 ST6GALNAC3 1.34 1.26 0.16 1.36 0.22 RPS24 1.34 1.58 0.27 1.57 0.23 MAP3K7CL 1.34 2.79 0.49 2.46 0.48 ATP5A1 1.34 2.06 0.49 1.85 0.15 POLR3K 1.34 1.79 0.41 1.52 0.20 FAM175B 1.34 1.76 0.34 1.52 0.14 RAB12 1.34 1.53 0.30 1.35 0.19 KLHDC3 1.34 0.91 0.17 0.76 0.14 COX5A 1.33 0.72 0.09 0.58 0.15 CFHR3 1.33 1.28 0.20 1.00 0.38 CDO1 1.33 2.12 0.31 2.08 0.70 PGRMC1 1.33 0.77 0.10 0.74 0.12 EHD4 1.33 0.42 0.07 0.42 0.08 TPO 1.33 0.22 0.05 0.24 0.11 P2RY2 1.33 1.37 0.18 1.33 0.13 EIF4EBP2 1.32 0.56 0.12 0.56 0.15 PTP4A2 1.32 0.80 0.16 0.80 0.13 IL21 1.32 1.51 0.30 1.63 0.17 POLR3D 1.32 1.85 0.31 1.75 0.26 GPT 1.32 1.39 0.19 1.47 0.15 LPXN 1.32 1.75 0.16 1.79 0.22 ZMYM2 1.32 0.58 0.09 0.67 0.13 FDX1L 1.31 1.09 0.14 1.07 0.13 EFNA3 1.31 1.96 0.18 1.94 0.38 CHCHD10 1.31 2.06 0.40 1.80 0.59 UQCRH 1.31 0.46 0.06 0.42 0.08 RBP4 1.31 0.56 0.05 0.48 0.13 DCP2 1.31 1.33 0.20 1.36 0.17 GSTA3 1.31 1.01 0.12 0.96 0.22 KRTAP9-9 1.31 0.67 0.10 0.56 0.15 TPI1 1.31 1.88 0.45 1.69 0.18 BIRC2 1.30 2.50 0.55 2.25 0.34 EREG 1.30 1.40 0.21 1.31 0.28 FOXP2 1.30 1.88 0.24 1.53 0.39 MT1X 1.30 1.94 0.39 1.54 0.40 PPAP2B 1.30 2.45 0.37 2.01 0.54 AP1M2 1.30 2.55 0.44 2.16 0.71 KRT8 1.29 1.23 0.15 1.08 0.19 KERA 1.29 0.60 0.07 0.51 0.15 DHRS3 1.29 0.60 0.12 0.58 0.07 PRDX2 1.29 1.71 0.22 1.72 0.35

Camacho-Encina M, et al. Ann Rheum Dis 2019; 0:1699ÿý1705. doi: 10.1136/annrheumdis-2019-215325 Supplementary material Ann Rheum Dis

CNOT10 1.29 2.03 0.19 2.00 0.38 XRN1 1.29 1.90 0.23 1.99 0.31 IFI30 1.29 1.72 0.30 1.76 0.31 S100A8 1.28 1.88 0.27 1.82 0.22 IL4 1.28 0.42 0.13 0.46 0.11 ARSA 1.28 1.67 0.33 1.73 0.49 ZP3 1.28 0.82 0.11 0.85 0.16 LONRF1 1.28 1.83 0.46 2.01 0.60 MC3R 1.28 2.13 0.42 1.77 0.49 CYBB 1.28 1.62 0.23 1.57 0.12 ZNF519 1.28 1.16 0.09 1.04 0.14 RAB27B 1.28 1.50 0.14 1.41 0.21 SRMS 1.28 1.00 0.12 0.90 0.24 POLD1 1.28 1.67 0.26 1.66 0.54 RPL11 1.28 0.89 0.20 0.84 0.22 GAB3 1.28 0.81 0.15 0.80 0.17 CA12 1.28 1.28 0.25 1.10 0.23 CHST11 1.28 1.48 0.26 1.26 0.15 ZNF547 1.28 2.31 0.64 2.01 0.28 MED16 1.27 1.39 0.19 1.17 0.28 CDK9 1.27 1.58 0.29 1.31 0.23 MTHFD2 1.27 1.07 0.16 0.89 0.17 RAB11B 1.27 1.44 0.20 1.20 0.22 MXD4 1.27 1.71 0.23 1.34 0.21 CDKN1B 1.27 1.63 0.20 1.31 0.27 PFKFB1 1.27 1.01 0.11 0.87 0.16 KLHL13 1.27 1.62 0.19 1.50 0.22 HMGB1 1.27 1.35 0.12 1.28 0.23 RNF6 1.26 1.78 0.19 1.58 0.19 RTN4R 1.26 1.88 0.22 1.67 0.19 FLOT2 1.26 1.85 0.26 1.61 0.19 C11orf57 1.26 1.12 0.17 1.07 0.35 AKR1A1 1.26 1.19 0.12 1.08 0.16 CDX1 1.26 1.26 0.18 1.22 0.13 RPS27L 1.26 1.37 0.20 1.35 0.19 ATP6AP1 1.26 1.65 0.21 1.46 0.21 HLA-DPA1 1.26 1.93 0.23 1.63 0.24 CTSO 1.26 3.16 0.51 2.64 0.69 PSMC3 1.25 1.35 0.21 1.07 0.31 TIMP2 1.25 1.49 0.27 1.43 0.23 C7orf49 1.25 1.84 0.31 1.57 0.26 CCNB1IP1 1.25 2.23 0.32 1.77 0.31 TRIAP1 1.25 3.42 0.71 2.77 0.56 HDHD1 1.25 0.05 0.04 0.01 0.02 MGLL 1.25 0.64 0.20 0.56 0.19 ANXA2 1.24 0.34 0.14 0.35 0.17 NDUFA9 1.24 0.16 0.11 0.13 0.09 PDHA1 1.24 0.33 0.16 0.40 0.19 LPCAT1 1.24 0.20 0.10 0.17 0.11 SH3GL1 1.24 0.25 0.19 0.19 0.12 DEFB1 1.24 0.10 0.05 0.08 0.07 HOMER1 1.24 0.25 0.06 0.28 0.12 OR52I1 1.23 0.34 0.09 0.41 0.15 HBB 1.23 0.36 0.09 0.52 0.18 MXD1 1.23 0.96 0.15 0.99 0.30 CORO1C 1.23 1.21 0.52 1.17 0.55 ARHGDIA 1.23 0.19 0.13 0.28 0.18 TOMM22 1.23 0.78 0.16 0.99 0.33

Camacho-Encina M, et al. Ann Rheum Dis 2019; 0:1699ÿý1705. doi: 10.1136/annrheumdis-2019-215325 Supplementary material Ann Rheum Dis

NDUFB7 1.23 0.65 0.14 0.79 0.28 EEF1A1 1.23 1.04 0.24 0.85 0.40 APEX1 1.23 0.12 0.11 0.12 0.11 ARFIP2 1.23 0.11 0.06 0.09 0.09 ZNF490 1.23 0.24 0.12 0.25 0.13 GHRL 1.23 0.29 0.18 0.20 0.19 PDE1C 1.22 0.46 0.39 0.46 0.34 GPATCH2L 1.22 0.08 0.05 0.06 0.05 MAP4K1 1.22 0.14 0.10 0.10 0.07 ERO1A 1.22 0.10 0.07 0.09 0.06 DOK4 1.22 0.34 0.15 0.28 0.09 ZKSCAN5 1.22 0.17 0.07 0.12 0.04 PTDSS1 1.22 0.09 0.04 0.05 0.05 ZNF34 1.22 0.25 0.11 0.26 0.13 SLC35B2 1.21 1.44 0.32 1.62 0.67 ASB7 1.21 1.28 0.26 1.31 0.22 IL7 1.21 1.20 0.24 1.20 0.24 GLYAT 1.21 1.67 0.49 1.87 0.69 LEP 1.21 0.04 0.03 0.08 0.07 GABBR1 1.21 1.13 0.17 1.12 0.23 HLX 1.21 0.34 0.12 0.46 0.19 TEAD4 1.21 0.06 0.05 0.08 0.07 DHPS 1.21 0.05 0.05 0.07 0.07 HMOX1 1.21 0.81 0.24 0.84 0.31 ELMO2 1.21 0.15 0.07 0.06 0.09 AJUBA 1.21 0.04 0.04 0.03 0.07 C17orf59 1.21 0.97 0.13 1.00 0.10 FBXO5 1.21 1.76 0.52 1.81 0.32 SF3A1 1.21 2.81 0.74 3.04 1.15 CHP2 1.21 2.93 0.80 2.80 0.72 P2RX2 1.20 1.27 0.26 1.13 0.15 ABCG1 1.20 0.01 0.05 0.01 0.05 CD151 1.20 1.88 0.34 1.77 0.21 RNF144B 1.20 2.22 0.50 2.05 0.35 FABP1 1.20 1.65 0.32 1.57 0.17 SETD5 1.20 1.66 0.27 1.51 0.21 GJA4 1.20 3.29 0.58 3.26 1.25 ADM2 1.20 0.81 0.33 0.91 0.43 POLR2L 1.20 0.80 0.23 0.65 0.23 CASP6 1.20 1.18 0.20 1.23 0.21 PNPLA1 1.20 0.73 0.12 0.76 0.11 ELF3 1.20 1.17 0.14 1.19 0.16 TGFBR2 1.20 1.32 0.30 1.34 0.13 CRK 1.20 -0.02 0.03 -0.01 0.04 GAST 1.20 0.81 0.15 0.76 0.16 CCKBR 1.20 1.35 0.19 1.41 0.06 CHCHD4 1.20 3.27 0.56 3.22 1.28 pAnt7-cGST 1.20 2.25 0.18 1.97 0.56 AIFM2 1.19 1.56 0.12 1.43 0.15 RAB4B 1.19 0.65 0.30 0.95 0.50 PSMC1 1.19 2.00 0.49 2.29 1.00 YWHAG 1.19 1.39 0.25 1.43 0.21 ANKDD1A 1.19 1.33 0.17 1.36 0.18 CXCL8 1.19 1.54 0.29 1.52 0.20 PIGQ 1.19 1.56 0.39 1.47 0.18 TSPYL2 1.19 2.05 0.58 1.84 0.20 TNFRSF10D 1.19 4.16 0.77 3.60 0.66 CAPN1 1.19 2.04 0.40 1.92 0.29

Camacho-Encina M, et al. Ann Rheum Dis 2019; 0:1699ÿý1705. doi: 10.1136/annrheumdis-2019-215325 Supplementary material Ann Rheum Dis

GPR84 1.19 1.78 0.41 1.56 0.38 ETV6 1.19 0.11 0.06 0.15 0.09 MED23 1.19 1.53 0.27 1.42 0.16 PPP1R3C 1.19 1.46 0.20 1.40 0.25 FCGR2A 1.19 2.10 0.42 1.99 0.37 GPR68 1.19 0.38 0.07 0.36 0.06 MYL6 1.19 1.14 0.18 1.16 0.11 BLZF1 1.19 0.54 0.05 0.57 0.10 GNB2 1.18 1.19 0.16 1.21 0.08 MED4 1.18 1.17 0.16 1.30 0.10 FRAT2 1.18 1.51 0.21 1.71 0.24 LAMP1 1.18 0.91 0.20 1.00 0.08 TFDP2 1.18 2.97 0.34 3.35 0.98 SCIN 1.18 2.34 0.48 2.41 0.70 ICAM4 1.18 2.98 0.54 3.18 1.09 NTNG1 1.18 1.14 0.13 1.26 0.19 ATG5 1.18 0.24 0.06 0.27 0.08 GSTT1 1.17 3.19 0.33 3.21 1.23 C3AR1 1.17 1.57 0.16 1.44 0.26 SLC39A6 1.17 1.83 0.31 1.66 0.48 PGF 1.17 1.18 0.11 1.25 0.09 KPNA1 1.17 0.42 0.08 0.38 0.08 ACAT1 1.17 1.41 0.25 1.49 0.18 IFIT1 1.17 1.08 0.16 0.94 0.09 HIBADH 1.17 1.64 0.39 1.57 0.23 CSTF1 1.17 2.37 0.64 2.22 0.31 HIST1H2BL 1.17 1.70 0.39 1.62 0.28 SPP1 1.17 0.40 0.07 0.42 0.11 IGF2 1.17 2.08 0.43 1.93 0.40 SIRT5 1.17 1.85 0.32 1.65 0.28 NKX2-2 1.16 0.40 0.11 0.34 0.09 ALB 1.16 0.88 0.13 0.79 0.12 EPHX2 1.16 1.00 0.14 1.02 0.09 ELF2 1.16 0.89 0.14 0.87 0.09 L3HYPDH 1.16 1.10 0.15 1.11 0.12 ZNF354A 1.16 1.58 0.24 1.55 0.20 ABAT 1.16 0.50 0.10 0.43 0.08 SLC3A1 1.16 1.26 0.20 1.29 0.11 SLC38A5 1.16 0.93 0.16 0.93 0.12 CEP72 1.16 1.53 0.33 1.46 0.30 APIP 1.16 0.20 0.09 0.25 0.09 TSR3 1.16 1.95 0.23 1.91 0.36 ZNF567 1.16 0.72 0.10 0.74 0.18 ADGRB3 1.16 0.66 0.07 0.63 0.12 BAG1 1.15 0.44 0.05 0.44 0.10 PRKAR2B 1.15 0.89 0.09 0.77 0.18 RAC3 1.15 1.49 0.17 1.40 0.45 MIS18A 1.15 1.06 0.09 1.03 0.10 NT5C3A 1.15 0.25 0.05 0.26 0.12 ATF3 1.15 1.32 0.15 1.17 0.25 GTF2H1 1.15 0.22 0.06 0.18 0.09 SDHD 1.15 1.62 0.37 1.43 0.16 FIP1L1 1.15 1.96 0.47 1.77 0.22 LYVE1 1.14 0.73 0.12 0.64 0.19 PLA2G2E 1.14 1.41 0.30 1.35 0.15 SYNE4 1.14 1.16 0.22 1.11 0.19 ARNTL 1.14 1.22 0.24 1.08 0.12 SLC13A3 1.14 1.42 0.30 1.30 0.16

Camacho-Encina M, et al. Ann Rheum Dis 2019; 0:1699ÿý1705. doi: 10.1136/annrheumdis-2019-215325 Supplementary material Ann Rheum Dis

LPAR1 1.14 1.13 0.18 1.02 0.12 TCERG1L 1.14 1.39 0.20 1.36 0.21 PTPN2 1.14 1.73 0.25 1.81 0.29 GSTK1 1.14 0.66 0.09 0.66 0.06 SLC26A4 1.14 0.21 0.03 0.27 0.10 CHST14 1.14 1.13 0.17 1.13 0.14 CAPN5 1.14 0.31 0.08 0.36 0.09 ACKR2 1.14 0.98 0.17 1.00 0.13 ATIC 1.14 1.20 0.22 1.20 0.13 YARS2 1.14 0.46 0.11 0.48 0.10 GPR15 1.14 0.75 0.10 0.74 0.15 CBLN1 1.14 1.28 0.15 1.26 0.14 NPY1R 1.14 0.96 0.12 0.95 0.10 EIF4E 1.14 1.37 0.09 1.39 0.18 EBI3 1.13 1.54 0.17 1.41 0.26 CRP 1.13 1.78 0.20 1.52 0.34 COX7B 1.13 0.22 0.04 0.22 0.12 SF3A3 1.13 1.25 0.10 1.18 0.13 CREB3L4 1.13 0.71 0.10 0.69 0.12 ADRA1D 1.13 0.59 0.08 0.55 0.12 LYPD6B 1.13 0.56 0.09 0.48 0.12 TCIRG1 1.13 2.29 0.39 1.98 0.25 MTERF2 1.13 2.69 0.69 2.21 0.33 ELAVL1 1.13 1.67 0.32 1.50 0.18 CD200R1 1.13 2.05 0.29 1.81 0.19 BAD 1.12 1.65 0.26 1.44 0.19 PAK4 1.12 1.45 0.20 1.03 0.25 TTC26 1.12 1.96 0.26 1.49 0.32 ATF1 1.12 1.67 0.36 1.51 0.29 GNA15 1.12 0.70 0.11 0.63 0.08 VTN 1.12 1.23 0.21 1.19 0.20 ENO1 1.12 0.76 0.07 0.67 0.10 SRPK1 1.12 0.92 0.10 0.81 0.13 AUH 1.12 0.93 0.10 0.82 0.13 PHTF1 1.11 1.37 0.23 1.06 0.16 POLD4 1.11 1.36 0.19 1.30 0.13 SUFU 1.11 0.97 0.14 0.89 0.17 ZDHHC21 1.11 1.42 0.20 1.38 0.18 ANGPTL3 1.11 2.01 0.28 1.97 0.43 SIAH1 1.11 1.67 0.21 1.51 0.25 AKT1 1.11 1.63 0.21 1.65 0.31 CYP4F8 1.11 0.42 0.33 0.47 0.21 RBP2 1.10 3.30 0.52 3.14 0.69 LSM6 1.10 1.33 0.27 1.33 0.17 H3F3A 1.10 1.13 0.22 1.09 0.16 UBE2D1 1.10 1.14 0.20 0.98 0.21 SRGN 1.10 1.87 0.29 1.58 0.35 AIRE 1.10 1.48 0.36 1.14 0.29 EXOSC8 1.10 0.75 0.23 0.80 0.35 HSD3B1 1.10 0.62 0.21 0.55 0.21 NPM1 1.10 1.20 0.27 1.03 0.42 EZH2 1.10 0.21 0.10 0.23 0.14 KIR2DL1 1.10 0.08 0.08 0.08 0.05 USP16 1.09 1.33 0.33 1.18 0.41 GPX1 1.09 0.31 0.13 0.36 0.16 EDNRB 1.09 1.46 0.23 1.54 0.28 KCNA6 1.09 1.25 0.19 1.31 0.19 CBFB 1.09 1.87 0.23 1.77 0.40

Camacho-Encina M, et al. Ann Rheum Dis 2019; 0:1699ÿý1705. doi: 10.1136/annrheumdis-2019-215325 Supplementary material Ann Rheum Dis

CALCA 1.09 1.15 0.16 1.18 0.13 ACTR1A 1.08 1.24 0.17 1.30 0.20 WNT11 1.08 1.08 0.16 1.14 0.08 UGT1A5 1.08 0.16 0.08 0.23 0.10 AKR1B1 1.08 0.51 0.09 0.55 0.21 EHD3 1.08 0.30 0.06 0.40 0.17 MC1R 1.08 0.44 0.09 0.55 0.18 ACY1 1.08 0.17 0.06 0.28 0.16 IL1R2 1.08 2.24 1.18 2.17 1.19 NSDHL 1.08 1.24 0.25 1.30 0.46 ZHX2 1.08 0.51 0.13 0.66 0.30 ADIPOR2 1.08 0.38 0.12 0.37 0.15 TCF7 1.08 0.83 0.09 0.80 0.13 GIGYF2 1.08 0.74 0.10 0.79 0.19 MYF6 1.08 0.95 0.14 0.94 0.21 OR6C3 1.08 0.71 0.10 0.68 0.13 ST3GAL3 1.08 1.40 0.25 1.23 0.18 CAP2 1.08 1.19 0.65 0.71 0.15 CSF3 1.08 0.32 0.17 0.32 0.15 KLF10 1.07 0.08 0.09 0.06 0.06 GALNT10 1.07 0.05 0.08 0.05 0.06 GPR173 1.07 0.05 0.08 0.04 0.06 OR2T1 1.07 0.20 0.24 0.23 0.26 ECH1 1.07 1.99 0.49 1.96 0.94 CD63 1.07 0.57 0.17 0.54 0.08 ACO2 1.07 0.08 0.11 0.07 0.07 PATL1 1.07 0.92 0.95 0.98 0.98 KIF2C 1.06 1.28 1.32 1.34 1.52 CTNNB1 1.06 0.23 0.09 0.31 0.15 DHCR24 1.06 0.08 0.04 0.07 0.08 TYROBP 1.06 0.08 0.05 0.07 0.07 VIPR2 1.06 0.03 0.03 0.09 0.09 CXCL13 1.06 1.68 0.38 1.62 0.64 LPAR5 1.06 0.75 0.09 0.76 0.12 PCBP1 1.06 0.39 0.13 0.35 0.14 DEFA1 1.06 0.26 0.10 0.21 0.12 SERINC5 1.06 0.09 0.10 0.06 0.08 MTMR6 1.06 0.26 0.15 0.19 0.11 MYO1F 1.06 0.30 0.13 0.15 0.07 SERPINA5 1.05 1.07 0.27 1.21 0.57 KCNS3 1.05 0.39 0.15 0.45 0.16 PSMB1 1.05 3.03 0.57 2.54 0.86 STK32A 1.05 0.71 0.32 0.62 0.35 MMP1 1.05 1.66 0.70 1.27 0.71 ZNF529 1.05 2.58 0.44 2.44 0.96 PLEKHA8P1 1.05 1.12 0.19 1.04 0.20 STARD6 1.05 0.06 0.04 0.05 0.07 TOR1A 1.05 0.12 0.08 0.12 0.11 E2F5 1.05 0.51 0.10 0.47 0.10 SLCO3A1 1.05 1.15 0.19 1.12 0.16 FKBP2 1.05 0.95 0.16 1.01 0.13 ARG1 1.05 2.46 0.34 2.58 0.75 ACADS 1.05 1.29 0.20 1.41 0.10 GJB3 1.05 0.31 0.12 0.58 0.23 TSG101 1.05 0.97 0.18 1.30 0.63 LARS2 1.05 0.80 0.14 0.94 0.07 IRF1 1.05 0.32 0.14 0.53 0.22 CENPP 1.04 0.93 0.25 0.85 0.43

Camacho-Encina M, et al. Ann Rheum Dis 2019; 0:1699ÿý1705. doi: 10.1136/annrheumdis-2019-215325 Supplementary material Ann Rheum Dis

PELO 1.04 1.17 0.11 1.22 0.21 BACH1 1.04 1.12 0.18 1.04 0.34 NDEL1 1.04 0.12 0.08 0.10 0.09 RPP38 1.04 0.15 0.05 0.14 0.09 RBMX2 1.04 0.80 0.12 0.84 0.20 GNB2L1 1.04 0.99 0.11 0.92 0.17 HBA2 1.04 1.64 0.29 1.61 0.41 CREB3L1 1.04 2.31 0.44 1.90 0.48 TBC1D10B 1.04 0.87 0.21 0.66 0.18 TBX5 1.04 1.96 0.45 1.79 0.43 JUNB 1.04 0.19 0.06 0.18 0.09 ATP6V0D1 1.04 1.62 0.27 1.45 0.35 LSM5 1.04 1.49 0.32 1.23 0.31 SAA1 1.04 1.86 0.25 1.80 0.46 LSM7 1.03 1.79 0.41 1.79 0.58 IL19 1.03 0.53 0.14 0.51 0.12 CTNNBIP1 1.03 1.17 0.23 1.29 0.23 CYP2S1 1.03 0.75 0.11 0.80 0.08 PDHA2 1.03 0.80 0.14 0.86 0.06 TCEB3 1.03 0.72 0.14 0.79 0.12 BIRC7 1.03 0.87 0.15 0.94 0.08 TNFRSF1A 1.03 0.98 0.18 1.07 0.13 POLA2 1.03 1.04 0.11 1.11 0.10 FEN1 1.03 0.90 0.12 1.01 0.11 RHOBTB1 1.02 0.98 0.14 1.11 0.14 ERRFI1 1.02 1.02 0.14 1.09 0.13 LRR1 1.02 2.43 0.30 2.46 0.77 SLC16A8 1.02 1.69 0.19 1.76 0.69 FKBP6 1.02 1.49 0.14 1.39 0.44 CYP2A13 1.02 0.65 0.11 0.66 0.14 SC5D 1.02 0.77 0.11 0.81 0.17 INPP5E 1.02 0.83 0.12 0.80 0.15 IL13RA1 1.02 0.90 0.12 0.89 0.19 DLST 1.02 1.07 0.23 0.88 0.11 HEBP1 1.01 1.28 0.32 1.07 0.16 S100A7 1.01 2.94 0.38 2.64 0.74 ACKR3 1.01 1.90 0.29 1.95 0.47 GNAS 1.00 2.45 0.36 2.19 0.63 SHISA5 1.00 1.52 0.26 1.36 0.20 GPHN 1.00 2.71 0.35 2.42 0.79 CYTH2 1.00 2.08 0.40 1.91 0.54 ACTR3B 1.00 2.12 0.49 2.05 0.66 TTK 1.00 1.01 0.22 0.99 0.21 KRTAP3-3 1.00 0.86 0.14 0.97 0.08 HLA-E 1.00 0.85 0.08 0.90 0.06 NUP43 1.00 0.79 0.12 0.89 0.12 STAT3 1.00 0.89 0.10 1.07 0.12 RAB38 1.00 1.06 0.15 1.27 0.11 PPP1R15A 1.00 1.53 0.22 1.63 0.19 IGFBP3 0.99 1.90 0.18 1.95 0.25 TACR2 0.99 1.07 0.12 1.38 0.22 YWHAE 0.99 1.45 0.25 1.66 0.27 GPER1 0.99 1.64 0.15 1.74 0.31 RPL36 0.99 1.07 0.12 1.09 0.17 CHORDC1 0.99 1.58 0.11 1.54 0.45 MIF 0.99 2.06 0.19 1.87 0.69 FMO3 0.99 0.36 0.06 0.29 0.08 GFPT2 0.99 0.51 0.07 0.48 0.14

Camacho-Encina M, et al. Ann Rheum Dis 2019; 0:1699ÿý1705. doi: 10.1136/annrheumdis-2019-215325 Supplementary material Ann Rheum Dis

ADGRG1 0.99 1.05 0.13 1.00 0.15 GALR2 0.99 1.10 0.11 0.96 0.18 ADA 0.99 0.98 0.11 0.92 0.16 RRM1 0.98 0.70 0.08 0.50 0.16 LMX1B 0.98 1.82 0.47 1.61 0.21 IL1B 0.98 1.33 0.28 1.13 0.38 TIRAP 0.98 1.54 0.20 1.35 0.32 GZMA 0.98 1.62 0.29 1.44 0.29 IL10 0.98 0.92 0.18 0.82 0.39 RAB11A 0.98 2.12 0.35 1.95 0.50 DEFB106A 0.98 1.10 0.17 0.99 0.13 TBCB 0.98 1.27 0.21 1.17 0.21 KCNIP4 0.98 1.56 0.39 1.58 0.40 SREK1 0.98 1.11 0.18 1.23 0.17 IDO1 0.98 0.84 0.12 0.92 0.15 HTR3B 0.98 0.82 0.12 0.88 0.14 B4GALT7 0.98 1.15 0.13 1.27 0.13 ZNF302 0.98 0.98 0.14 0.96 0.18 ZIK1 0.98 1.03 0.17 1.08 0.18 ZNF317 0.98 1.03 0.12 1.04 0.21 HECTD3 0.98 1.47 0.14 1.54 0.21 POLR2C 0.97 1.48 0.24 1.63 0.22 FGF16 0.97 0.76 0.23 0.91 0.22 PPP2R4 0.97 1.10 0.14 1.19 0.17 RNF123 0.97 0.13 0.03 0.16 0.11 PROKR2 0.97 1.15 0.10 1.06 0.15 CYP2C8 0.97 1.35 0.35 1.36 0.27 DPM1 0.97 0.18 0.04 0.13 0.04 CXCL2 0.97 0.11 0.04 0.08 0.04 CCR7 0.97 0.21 0.05 0.18 0.08 RPL39 0.97 0.62 0.09 0.55 0.16 TFF1 0.97 0.83 0.15 0.69 0.12 TMOD1 0.97 1.09 0.23 0.82 0.27 CYLC2 0.97 2.08 0.47 1.79 0.35 WNT7A 0.97 0.72 0.10 0.64 0.17 SNRPC 0.97 1.42 0.24 1.18 0.19 PSAP 0.97 1.60 0.27 1.36 0.22 CDC37 0.96 1.88 0.31 1.56 0.29 HMBS 0.96 1.56 0.23 1.33 0.21 GSTA5 0.96 1.12 0.20 1.16 0.15 TCEB2 0.96 1.46 0.34 1.58 0.35 COIL 0.96 1.14 0.14 1.12 0.11 FOXA2 0.96 1.05 0.13 0.99 0.15 PTGER3 0.96 1.51 0.23 1.44 0.28 RPL8 0.96 1.09 0.13 0.98 0.21 UBE2L6 0.96 1.46 0.82 1.95 0.94 BCL2L1 0.96 1.19 0.13 1.37 0.10 NCEH1 0.96 0.91 0.09 0.88 0.15 GTF2F1 0.96 1.17 0.21 1.19 0.13 IRF4 0.96 1.36 0.19 1.36 0.17 p53 0.96 0.86 0.12 0.83 0.22 VPS39 0.95 1.62 0.19 1.40 0.25 SULT2B1 0.95 0.64 0.07 0.59 0.17 PKIA 0.95 0.63 0.10 0.56 0.14 GDI1 0.95 0.83 0.12 0.73 0.18 FAM19A5 0.95 1.05 0.14 0.93 0.22 MTAP 0.95 1.70 0.24 1.46 0.23 SNRPF 0.95 2.16 0.44 1.68 0.32

Camacho-Encina M, et al. Ann Rheum Dis 2019; 0:1699ÿý1705. doi: 10.1136/annrheumdis-2019-215325 Supplementary material Ann Rheum Dis

GSTZ1 0.95 0.21 0.12 0.21 0.14 ZNF157 0.95 1.33 0.24 1.26 0.40 TMEM218 0.95 0.23 0.09 0.27 0.13 UBE2K 0.95 0.19 0.10 0.25 0.16 RNF185 0.95 0.10 0.07 0.07 0.08 TMEM201 0.94 0.08 0.06 0.07 0.06 IDH3B 0.94 0.13 0.06 0.20 0.12 CDC27 0.94 0.14 0.05 0.19 0.10 UBA6 0.94 0.11 0.05 0.18 0.11 SLC26A5 0.94 0.20 0.09 0.35 0.14 PRMT2 0.94 0.71 0.14 0.94 0.28 CTSH 0.94 0.68 0.33 0.70 0.33 DNAJB11 0.94 0.65 0.16 0.86 0.25 CDC34 0.93 0.49 0.12 0.67 0.21 DEFB115 0.93 0.14 0.10 0.21 0.16 DCTN6 0.93 0.08 0.06 0.12 0.08 F2RL2 0.93 0.24 0.16 0.29 0.19 REN 0.93 0.33 0.11 0.27 0.12 NFKBIA 0.93 0.26 0.14 0.21 0.15 PPP2R5E 0.93 0.19 0.11 0.15 0.10 AKR7A2 0.92 0.25 0.13 0.18 0.09 CDC25A 0.92 0.41 0.15 0.33 0.12 MB 0.92 0.12 0.10 0.15 0.15 SPR 0.92 0.10 0.07 0.08 0.06 ACER3 0.92 0.12 0.07 0.11 0.06 RHOC 0.92 0.04 0.06 0.03 0.04 FGF18 0.92 0.03 0.05 0.04 0.04 KCNIP3 0.92 -0.02 0.04 -0.01 0.04 SFN 0.92 -0.02 0.03 -0.01 0.04 TRIP6 0.91 2.53 0.55 3.03 1.10 HRH2 0.91 1.65 0.45 2.12 0.64 RXRA 0.91 1.38 0.29 1.57 0.38 CERS2 0.91 2.26 0.35 3.00 0.82 ATG10 0.91 0.06 0.04 0.07 0.07 TXN2 0.91 2.20 0.35 2.83 0.98 HADH 0.91 0.03 0.03 0.06 0.07 MSN 0.91 0.01 0.03 0.04 0.10 PDC 0.91 1.34 0.15 1.42 0.25 ATF4 0.91 -0.01 0.02 -0.02 0.05 PRDX1 0.90 0.20 0.08 0.22 0.11 COPE 0.90 0.64 0.09 0.61 0.14 PTGIR 0.90 1.62 1.26 1.65 1.26 TSHB 0.90 1.29 0.19 1.10 0.39 CDCP1 0.90 1.81 0.34 1.81 0.69 HEATR1 0.90 0.94 0.12 0.82 0.18 BIRC5 0.90 1.53 1.63 1.38 1.46 RTN4 0.90 0.10 0.07 0.06 0.05 SEC61G 0.90 0.02 0.04 0.02 0.05 DRD5 0.90 2.13 0.38 2.32 0.79 S1PR2 0.90 1.66 0.33 1.56 0.32 AKR7A3 0.90 2.37 0.36 2.56 0.85 RPS17 0.90 1.54 0.28 1.69 0.42 UBE2I 0.90 0.52 0.19 0.42 0.15 FGF10 0.90 0.84 0.40 0.88 0.45 ATP6V0D2 0.89 2.27 0.50 2.67 0.75 OR7D2 0.89 1.27 0.15 1.27 0.20 SMAD9 0.89 0.36 0.10 0.34 0.10 PLAT 0.89 0.96 0.10 1.01 0.11

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DSE 0.89 0.63 0.14 0.72 0.27 CYB5A 0.89 1.12 0.21 1.26 0.20 C16orf59 0.89 0.04 0.05 0.04 0.05 COX6B2 0.89 1.44 1.38 1.73 1.76 SH3GLB1 0.89 1.74 0.17 1.74 0.30 PIN1 0.89 2.89 0.55 3.06 1.16 OXCT1 0.88 1.22 0.12 1.24 0.15 F2RL1 0.88 1.70 0.48 1.80 0.64 SLC25A15 0.88 2.08 0.58 2.18 0.75 F2R 0.88 1.08 0.14 1.13 0.15 NRF1 0.88 1.08 0.14 1.02 0.12 GABRE 0.88 1.15 0.16 1.02 0.17 RPL26L1 0.88 0.09 0.04 0.03 0.02 PRL 0.88 1.48 0.33 1.48 0.24 MTERF1 0.88 2.05 0.41 2.02 0.51 PEX3 0.88 1.47 0.31 1.45 0.25 TUBA1B 0.88 0.86 0.21 0.85 0.14 TYMS 0.88 1.40 0.32 1.37 0.31 ICOSLG 0.88 1.16 0.23 1.28 0.27 ALDH1A2 0.88 1.52 0.38 1.60 0.53 TNFRSF11B 0.87 0.89 0.18 0.95 0.12 SIGMAR1 0.87 0.95 0.18 1.05 0.19 RHOB 0.87 0.81 0.10 0.91 0.10 SLC2A8 0.87 0.82 0.15 0.96 0.12 OS9 0.87 0.83 0.15 0.90 0.13 IFNA16 0.87 1.19 0.21 1.33 0.07 RASSF3 0.87 2.67 0.42 3.10 0.90 MMP2 0.87 1.04 0.17 1.30 0.15 PHF21A 0.87 1.03 0.19 1.21 0.18 GPR27 0.87 1.44 0.20 1.74 0.30 NTS 0.87 1.54 0.17 1.58 0.24 GJB4 0.86 1.74 0.30 2.10 0.77 LOC100506688 0.86 2.13 0.37 2.40 0.78 LIMK1 0.86 0.03 0.02 0.06 0.12 GSTA1 0.86 0.08 0.14 0.02 0.03 ITGA10 0.86 0.23 0.24 0.02 0.02 PLEK 0.86 0.05 0.03 0.07 0.12 GPRC5D 0.86 0.14 0.17 0.13 0.20 EIF2A 0.86 0.16 0.16 0.11 0.15 P2RY12 0.86 0.59 0.14 0.49 0.28 IVD 0.86 1.97 0.35 2.05 0.33 AQP5 0.86 2.46 1.04 2.51 1.40 DDX54 0.86 1.48 0.30 1.43 0.29 TERF2IP 0.86 0.92 0.19 0.91 0.14 KRT19 0.86 0.32 0.08 0.32 0.06 MRI1 0.86 0.37 0.09 0.36 0.04 CD81 0.86 1.06 0.20 1.14 0.20 WIF1 0.86 0.76 0.16 0.82 0.10 FARP1 0.85 0.75 0.12 0.82 0.10 TAF1B 0.85 1.00 0.14 0.97 0.13 KLHL12 0.85 0.85 0.14 0.96 0.10 THY1 0.85 1.03 0.16 1.11 0.12 RELA 0.85 0.89 0.16 0.92 0.16 GTF2A2 0.85 1.47 0.17 1.73 0.16 NFIL3 0.84 1.25 0.14 1.43 0.12 ZFYVE9 0.84 0.59 0.14 0.76 0.21 ZNF767P 0.84 1.13 0.19 1.42 0.27 CER1 0.84 0.80 0.10 0.93 0.08

Camacho-Encina M, et al. Ann Rheum Dis 2019; 0:1699ÿý1705. doi: 10.1136/annrheumdis-2019-215325 Supplementary material Ann Rheum Dis

IL18 0.84 0.71 0.11 0.83 0.19 BRK1 0.84 0.12 0.04 0.16 0.09 CXCR1 0.84 0.28 0.05 0.26 0.07 PWP1 0.84 0.35 0.05 0.40 0.07 FPR2 0.84 0.30 0.05 0.32 0.12 KCNMB3 0.84 0.45 0.07 0.42 0.07 PEX19 0.84 0.55 0.14 0.55 0.13 WNT9A 0.84 0.55 0.13 0.52 0.07 SLC20A1 0.84 1.05 0.20 1.05 0.16 UGT2B15 0.84 1.01 0.19 0.92 0.07 AICDA 0.84 1.12 0.21 1.03 0.15 SLC24A3 0.83 1.82 0.88 1.68 0.76 RBMX 0.83 1.25 0.25 1.26 0.25 GRB10 0.83 0.62 0.14 0.64 0.07 RDH12 0.83 0.80 0.18 0.87 0.15 GPR65 0.83 0.50 0.10 0.55 0.06 ACTB 0.83 0.25 0.05 0.31 0.06 XRCC3 0.83 0.53 0.08 0.57 0.08 SNRPD2 0.83 0.74 0.12 0.81 0.11 GINS2 0.83 0.50 0.11 0.51 0.16 SLC18A1 0.83 0.65 0.15 0.71 0.24 RPA4 0.83 0.53 0.14 0.65 0.25 NOSIP 0.83 1.02 0.12 1.03 0.16 NANOS2 0.82 1.03 0.15 1.19 0.17 PRKCH 0.82 0.78 0.13 0.97 0.26 KRTAP1-3 0.82 0.82 0.11 1.01 0.21 VAMP2 0.82 1.48 0.18 1.61 0.21 CHST12 0.82 1.08 0.11 1.23 0.14 GALT 0.82 0.16 0.04 0.15 0.07 RFC4 0.82 0.41 0.05 0.46 0.10 OR51A2 0.82 0.26 0.07 0.23 0.09 RUVBL2 0.82 0.63 0.11 0.53 0.09 GPR183 0.81 0.44 0.05 0.41 0.11 SCARA5 0.81 0.48 0.09 0.44 0.11 ABLIM3 0.81 1.58 0.32 1.61 0.30 TRIM51 0.81 1.41 0.18 1.37 0.17 ENO3 0.81 1.13 0.16 1.03 0.21 BOK 0.81 1.00 0.15 0.86 0.12 ADH4 0.81 1.57 0.25 1.45 0.25 ZNF707 0.81 1.25 0.34 1.26 0.19 ATP5L 0.81 0.97 0.28 0.94 0.31 KPNA3 0.81 0.81 0.20 0.81 0.14 RAB30 0.81 1.04 0.28 1.18 0.22 C7orf26 0.81 1.09 0.22 1.19 0.22 ZNF684 0.80 0.61 0.10 0.58 0.12 HTR5A 0.80 1.17 0.19 1.14 0.15 ZNF493 0.80 0.70 0.17 0.82 0.12 STX6 0.80 1.15 0.14 1.23 0.09 TTC39C 0.80 1.15 0.14 1.24 0.13 PNMT 0.80 0.72 0.16 0.77 0.21 TNFSF13 0.80 1.06 0.21 1.09 0.15 SIRT2 0.80 1.46 0.23 1.66 0.20 CCL20 0.80 1.16 0.16 1.18 0.20 ANXA1 0.80 2.03 1.09 2.51 1.05 TRIM62 0.80 0.45 0.05 0.39 0.07 RPS6KA6 0.79 0.46 0.08 0.47 0.06 ECHDC1 0.79 0.35 0.06 0.33 0.10 SLC25A10 0.79 0.43 0.08 0.51 0.11

Camacho-Encina M, et al. Ann Rheum Dis 2019; 0:1699ÿý1705. doi: 10.1136/annrheumdis-2019-215325 Supplementary material Ann Rheum Dis

CST3 0.79 0.24 0.11 0.13 0.06 UCHL1 0.79 0.92 0.16 0.69 0.17 IFI35 0.79 0.44 0.15 0.48 0.25 PSME3 0.79 0.23 0.09 0.22 0.12 MOS 0.79 0.31 0.11 0.33 0.13 EDN1 0.79 0.60 0.18 0.59 0.23 CXCL5 0.79 0.61 0.17 0.66 0.27 MIA 0.79 0.68 0.28 0.90 0.43 PSAT1 0.79 1.05 0.22 1.15 0.23 PLD5 0.79 0.69 0.22 0.85 0.07 EFNB2 0.78 0.85 0.17 0.93 0.10 NAT14 0.78 1.50 0.18 1.61 0.23 OXLD1 0.78 0.76 0.43 0.65 0.32 NAA50 0.78 0.58 0.19 0.68 0.26 CSNK1G2 0.78 0.21 0.08 0.31 0.12 GZMB 0.78 0.23 0.05 0.29 0.13 RRAD 0.78 0.23 0.06 0.30 0.11 ABHD10 0.78 1.10 0.97 1.31 1.18 MRPS24 0.78 0.56 0.16 0.72 0.26 IBSP 0.77 1.22 0.36 1.52 0.52 CWF19L2 0.77 0.27 0.11 0.29 0.23 CGA 0.77 0.08 0.06 0.06 0.06 NRP1 0.77 0.81 0.14 0.98 0.24 ZC3H14 0.77 2.76 0.37 2.56 0.36 COX4I1 0.77 1.38 0.26 1.35 0.13 GRB2 0.77 0.77 0.09 0.80 0.13 CD177 0.77 2.17 0.30 2.27 0.31 TREM1 0.77 0.15 0.06 0.13 0.14 GPR143 0.77 1.06 0.24 1.23 0.55 TPMT 0.77 0.05 0.08 0.05 0.06 GJA5 0.76 0.03 0.06 0.04 0.06 GGPS1 0.76 0.64 0.61 0.70 0.79 KITLG 0.76 0.23 0.11 0.31 0.11 IGFBP5 0.76 0.91 0.28 1.17 0.47 RHO 0.76 1.15 0.20 1.19 0.32 RPS29 0.76 0.05 0.05 0.06 0.07 HJURP 0.76 1.28 1.18 1.33 1.30 CDK5R1 0.76 0.15 0.13 0.23 0.13 CD207 0.76 0.02 0.05 0.06 0.05 MFAP3L 0.76 0.12 0.05 0.24 0.11 GATA3 0.76 0.91 0.96 0.98 1.09 ACTA1 0.76 0.01 0.03 0.05 0.07 FCGR3A 0.76 0.00 0.03 0.03 0.06 SLC31A1 0.76 0.00 0.03 0.02 0.06 TTLL10 0.76 1.62 0.36 2.06 0.80 ALG2 0.75 0.95 0.83 1.16 1.17 RGS18 0.75 1.85 0.46 2.13 0.52 EIF2B3 0.75 0.11 0.04 0.02 0.04 DEFB127 0.75 0.09 0.04 0.01 0.05 ST6GAL1 0.75 0.06 0.05 0.01 0.03 STAM2 0.75 0.68 0.28 0.56 0.27 KDELR3 0.75 1.06 0.29 1.64 0.56 GH1 0.75 1.51 0.30 1.66 0.65 OAS1 0.75 0.92 0.14 0.92 0.15 COX6B1 0.75 0.97 0.36 0.75 0.18 EFNA2 0.75 0.79 0.29 0.61 0.18 NCOA4 0.75 1.37 0.47 1.66 0.54 TRAM1 0.75 0.63 0.14 0.74 0.11

Camacho-Encina M, et al. Ann Rheum Dis 2019; 0:1699ÿý1705. doi: 10.1136/annrheumdis-2019-215325 Supplementary material Ann Rheum Dis

ID3 0.75 0.03 0.05 0.09 0.10 IL3 0.75 0.05 0.07 0.16 0.14 AQP8 0.74 0.99 0.11 1.14 0.20 PELI1 0.74 1.80 0.37 2.25 0.67 IMPA1 0.74 1.26 0.26 1.57 0.34 COX7A1 0.74 1.80 0.26 2.27 0.85 XPC 0.74 0.94 0.14 1.06 0.11 RAB34 0.74 0.92 0.44 1.08 0.61 ETHE1 0.74 0.43 0.08 0.62 0.29 RNASEH1 0.73 0.66 0.15 0.88 0.14 EIF3K 0.73 0.54 0.18 0.71 0.25 SLC27A5 0.73 1.29 0.44 1.56 0.56 SAR1A 0.73 2.34 0.40 2.76 0.86 CCND3 0.73 1.13 0.19 1.25 0.16 NDUFB8 0.73 1.00 0.94 0.98 0.75 SLC40A1 0.73 0.11 0.06 0.21 0.14 OPRL1 0.72 1.07 0.15 1.17 0.15 ALDH3A1 0.72 2.27 0.62 2.17 0.37 KLHL33 0.72 1.40 0.28 1.31 0.11 C2orf73 0.72 1.09 0.29 0.71 0.33 FASLG 0.72 1.44 0.25 1.44 0.21 PKDCC 0.72 1.11 0.19 1.16 0.34 UBE3A 0.72 1.02 0.16 1.05 0.16 NR3C1 0.72 1.07 0.25 1.03 0.24 NQO1 0.72 1.16 0.23 0.96 0.10 KPNA5 0.72 0.87 0.39 1.12 0.52 SPIRE1 0.72 1.89 0.58 2.16 0.75 GMPR 0.71 2.02 0.54 2.09 0.73 EBAG9 0.71 0.63 0.15 0.76 0.18 OR11G2 0.71 0.64 0.14 0.86 0.19 CSNK2A2 0.71 0.69 0.21 0.77 0.12 BNIP3 0.71 0.53 0.10 0.61 0.12 POLE3 0.71 0.70 0.23 0.82 0.27 CXCR2 0.70 1.98 0.37 2.19 0.59 COL10A1 0.70 2.52 0.48 3.07 0.91 WDR77 0.70 0.78 0.12 0.85 0.10 OR14C36 0.70 0.72 0.08 0.87 0.09 ALDH4A1 0.70 0.80 0.16 0.87 0.29 MAS1 0.70 2.88 0.68 3.20 0.94 GNGT1 0.70 2.04 0.35 2.30 0.57 ZNF518A 0.70 1.84 0.36 1.95 0.56 BCAT2 0.70 2.99 0.45 3.31 1.07 ACSL4 0.70 1.10 0.16 1.31 0.22 TPSAB1 0.70 0.82 0.09 0.91 0.22 ATP5C1 0.69 0.81 0.16 0.79 0.18 MMP10 0.69 1.14 0.19 1.22 0.11 IDI1 0.69 1.26 0.19 1.31 0.14 UBQLN4 0.69 2.11 0.41 1.96 0.33 ERAP1 0.69 2.76 1.84 2.27 1.75 POLR1C 0.69 1.53 0.32 1.71 0.49 OSM 0.69 0.57 0.57 0.62 0.64 RRM2B 0.69 1.48 0.28 1.67 0.42 LSM2 0.69 1.23 0.20 1.27 0.17 ADGRE1 0.68 1.04 0.15 1.10 0.17 ZNF550 0.68 0.66 0.20 0.76 0.23 CYSLTR1 0.68 1.37 0.38 1.34 0.47 GPR171 0.68 0.57 0.14 0.68 0.16 PDE8B 0.68 0.39 0.11 0.46 0.10

Camacho-Encina M, et al. Ann Rheum Dis 2019; 0:1699ÿý1705. doi: 10.1136/annrheumdis-2019-215325 Supplementary material Ann Rheum Dis

CHRNB3 0.68 0.81 0.08 0.96 0.17 DYNC2LI1 0.68 0.44 0.10 0.48 0.11 STAMBP 0.68 0.49 0.12 0.54 0.12 NFX1 0.68 1.47 0.24 1.47 0.42 RPLP2 0.68 1.08 0.19 1.01 0.18 POLR3F 0.67 1.01 0.17 1.16 0.09 HSPB1 0.67 1.02 0.16 1.28 0.13 ZFP36 0.67 1.51 0.31 1.84 0.45 STARD7 0.67 1.02 0.16 1.18 0.13 RUSC1-AS1 0.67 0.90 0.11 1.14 0.12 GALC 0.67 1.46 0.19 1.72 0.33 G0S2 0.67 2.19 0.38 2.39 0.67 ALKBH2 0.67 1.27 0.10 1.31 0.17 ZNF577 0.67 0.95 0.10 0.98 0.14 TERF1 0.67 0.99 0.14 0.98 0.13 EEF1A2 0.67 0.83 0.10 0.84 0.19 TAAR5 0.67 1.58 0.23 1.58 0.20 GPR75 0.66 0.18 0.05 0.14 0.09 OR2C3 0.66 2.02 0.42 1.69 0.32 RPL27 0.66 0.90 0.19 1.02 0.29 CRYAA 0.66 0.99 0.15 0.96 0.18 PITPNC1 0.66 1.33 0.22 1.25 0.26 GPR21 0.66 1.30 0.22 1.10 0.21 FZD7 0.66 1.67 0.31 1.68 0.38 HIST1H3A 0.66 1.05 0.26 1.06 0.23 PHAX 0.66 0.85 0.22 0.84 0.14 GNG3 0.66 0.27 0.11 0.38 0.18 MEF2BNB 0.65 1.01 0.20 1.24 0.28 CA13 0.65 0.33 0.09 0.40 0.08 P2RY10 0.65 0.70 0.16 0.73 0.13 AGTR1 0.65 0.60 0.19 0.67 0.16 OR5V1 0.65 0.72 0.13 0.75 0.08 SNAI1 0.64 0.49 0.10 0.55 0.11 NTSR1 0.64 0.97 0.12 1.13 0.10 RHBDD2 0.64 0.43 0.20 0.60 0.16 BRS3 0.64 1.21 0.37 1.36 0.30 TP53 0.64 1.18 0.27 1.38 0.19 TMCO6 0.64 0.93 0.11 0.99 0.12 ZNF664 0.64 1.14 0.11 1.12 0.18 TFDP1 0.63 1.56 0.37 1.48 0.43 PRPF38B 0.63 0.78 0.07 0.83 0.12 TAF1A 0.63 0.44 0.08 0.43 0.11 RBMY1A1 0.63 1.07 0.22 0.92 0.18 CD244 0.63 1.10 0.16 1.03 0.17 PDE5A 0.63 1.44 0.20 1.24 0.16 FKBP4 0.63 1.30 0.14 1.08 0.31 CD160 0.63 0.93 0.30 1.34 0.22 FGF12 0.63 0.56 0.09 0.49 0.12 MSMO1 0.63 1.03 0.16 1.01 0.13 PLAUR 0.62 0.83 0.10 0.75 0.07 CHMP5 0.62 1.35 0.19 1.21 0.12 EPS8L1 0.62 1.17 0.30 1.21 0.21 CHRM5 0.62 0.25 0.14 0.17 0.10 TMLHE 0.61 1.14 0.30 1.36 0.25 HAND1 0.61 1.26 0.39 1.54 0.33 CCR6 0.61 1.05 0.19 1.10 0.11 SERPINA3 0.61 1.06 0.18 1.07 0.18 ZNF541 0.61 1.33 0.21 1.45 0.23

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NDUFV3 0.61 1.18 0.22 1.15 0.23 MEPCE 0.61 1.51 0.23 1.47 0.22 CUL1 0.61 1.12 0.10 1.15 0.16 AEN 0.60 0.76 0.20 0.83 0.15 USP6NL 0.60 0.74 0.16 0.78 0.18 CYP2C18 0.60 1.13 0.22 1.12 0.24 ZNF155 0.60 1.15 0.18 1.12 0.20 CLOCK 0.60 1.16 0.10 1.17 0.10 GPR63 0.60 1.39 0.19 1.47 0.23 ZNF624 0.60 1.11 0.17 1.01 0.14 PRSS3 0.60 1.38 0.27 1.26 0.19 BTBD3 0.60 1.43 0.30 1.17 0.24 TIMM8B 0.60 1.85 0.27 1.38 0.26 HGS 0.60 3.19 1.08 3.32 1.41 SLC25A17 0.59 0.34 0.25 0.45 0.37 GRHPR 0.59 0.25 0.12 0.31 0.17 PLBD1 0.59 0.56 0.43 0.55 0.46 S1PR3 0.59 0.42 0.35 0.47 0.39 GPR20 0.59 0.07 0.08 0.12 0.11 GTSE1 0.59 0.10 0.11 0.18 0.14 RDH11 0.59 0.33 0.29 0.45 0.36 PLAG1 0.59 0.04 0.05 0.09 0.08 CAPG 0.59 0.13 0.15 0.24 0.23 PLXNC1 0.59 0.06 0.06 0.17 0.13 AP1G2 0.58 0.05 0.05 0.09 0.08 ADPRM 0.58 0.45 0.41 0.51 0.54 ACKR1 0.58 0.45 0.10 0.59 0.23 EBF1 0.58 0.13 0.08 0.25 0.12 NR2E1 0.58 0.35 0.07 0.51 0.24 C1orf127 0.58 0.53 0.10 0.66 0.22 CRHR1 0.58 0.20 0.07 0.35 0.16 F8A3 0.58 0.18 0.09 0.27 0.13 SULT1A1 0.58 0.46 0.14 0.63 0.19 RPL24 0.57 0.09 0.07 0.21 0.15 SSR1 0.57 0.14 0.09 0.20 0.13 PTGS2 0.57 0.66 0.18 0.83 0.32 ADRA1A 0.57 0.11 0.05 0.12 0.09 AQP10 0.57 0.10 0.05 0.10 0.08 PTCRA 0.57 0.28 0.09 0.31 0.09 ZDHHC19 0.57 0.40 0.16 0.43 0.15 PIGZ 0.57 0.27 0.15 0.33 0.23 TNNI2 0.57 0.50 0.17 0.43 0.15 CPN1 0.57 0.02 0.06 0.03 0.08 SLCO4C1 0.57 0.02 0.04 0.03 0.05 GSTA2 0.57 0.12 0.06 0.05 0.04 ZNF514 0.56 0.07 0.07 0.03 0.04 CNOT2 0.56 0.01 0.05 0.00 0.04 FXYD2 0.56 0.58 0.64 0.60 0.64 PROS1 0.56 0.01 0.05 0.03 0.04 UGT2B17 0.56 1.06 0.38 1.46 0.63 EHMT2 0.56 1.18 0.56 1.59 0.51 R3HDM2 0.55 0.06 0.07 0.11 0.06 OTULIN 0.55 0.34 0.12 0.34 0.11 MGAT2 0.55 0.72 0.27 0.80 0.25 ROBO3 0.55 1.69 0.38 1.97 0.68 WNT5A 0.55 1.46 0.72 1.47 0.70 KIR2DS4 0.55 0.03 0.05 0.12 0.11 EIF2S2 0.55 0.23 0.13 0.35 0.15

Camacho-Encina M, et al. Ann Rheum Dis 2019; 0:1699ÿý1705. doi: 10.1136/annrheumdis-2019-215325 Supplementary material Ann Rheum Dis

DSTN 0.54 0.01 0.02 0.05 0.06 RAD17 0.54 0.19 0.06 0.13 0.08 MAMSTR 0.54 0.03 0.04 0.02 0.05 pcite-HA 0.54 2.19 0.49 2.65 0.81 B2M 0.54 0.02 0.04 0.03 0.07 CXCR6 0.54 1.64 0.40 1.88 0.70 CDK5RAP3 0.54 1.16 0.38 1.21 0.33 GPBAR1 0.54 0.73 0.29 0.66 0.31 DLL1 0.54 0.48 0.14 0.48 0.27 GPR25 0.54 1.31 0.30 1.26 0.46 CDHR5 0.53 0.60 0.07 0.49 0.14 TRAF1 0.53 3.36 0.76 3.20 1.69 CCL18 0.53 0.05 0.05 0.05 0.04 ANXA6 0.53 0.18 0.16 0.20 0.21 CLDN16 0.53 0.57 0.33 0.43 0.22 PTEN 0.53 0.16 0.09 0.18 0.11 RBP7 0.53 0.39 0.17 0.40 0.17 GPRC5A 0.53 0.14 0.10 0.19 0.10 GSK3A 0.52 1.21 0.31 1.31 0.28 TRIM10 0.52 1.47 0.69 1.45 0.70 ETV5 0.52 0.83 0.29 1.02 0.20 MC4R 0.52 0.45 0.09 0.54 0.11 PDE4A 0.52 0.45 0.11 0.49 0.15 RAB13 0.52 1.25 0.15 1.31 0.24 TEX38 0.52 0.50 0.12 0.50 0.10 SEL1L3 0.52 0.67 0.11 0.73 0.08 SULT1C3 0.52 0.06 0.07 0.13 0.10 DRD2 0.52 0.06 0.07 0.12 0.08 S1PR4 0.51 2.01 0.66 2.49 0.73 ZNF573 0.51 0.19 0.12 0.31 0.16 KLK4 0.51 0.58 0.30 0.61 0.32 SLC35C1 0.51 0.08 0.06 0.15 0.12 KCNH4 0.51 0.80 0.13 0.90 0.27 PYCR1 0.51 2.31 0.61 2.43 0.98 MAU2 0.51 1.21 0.43 1.19 0.40 CCL7 0.51 0.95 0.44 0.81 0.48 IL27 0.50 1.15 0.18 1.21 0.13 ALOXE3 0.50 1.27 0.16 1.25 0.13 CDC45 0.50 1.34 0.17 1.30 0.11 B4GALT3 0.50 1.20 0.15 1.03 0.19 SCNN1D 0.50 0.95 0.14 1.25 0.27 LIG4 0.49 1.42 0.29 1.57 0.46 TYW1 0.49 0.89 0.17 0.98 0.19 RHOH 0.49 1.27 0.25 1.34 0.32 EDEM2 0.49 0.26 0.15 0.20 0.14 CSNK1A1L 0.49 0.35 0.21 0.74 0.27 FDPS 0.49 0.34 0.16 0.42 0.14 RSU1 0.48 0.39 0.31 0.48 0.38 SPOCK1 0.48 0.65 0.12 0.75 0.16 FAM25C 0.48 0.69 0.12 0.75 0.17 TDRD3 0.47 0.90 0.11 0.93 0.16 GSTM5 0.47 1.03 0.14 1.11 0.19 GDF3 0.47 0.90 0.12 1.02 0.10 RPS20 0.47 0.63 0.14 0.71 0.11 DCT 0.47 0.68 0.17 0.83 0.16 RAB27A 0.47 0.63 0.14 0.79 0.16 DGKZ 0.47 1.28 0.28 1.60 0.35 TMEM65 0.47 0.96 0.30 1.07 0.26

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GPR35 0.47 0.82 0.19 0.89 0.26 HYKK 0.46 1.54 0.53 1.51 0.59 NRAS 0.46 0.09 0.03 0.15 0.12 ABCD1 0.46 1.10 0.10 1.15 0.11 PAH 0.46 0.70 0.14 0.76 0.10 PIGL 0.46 0.85 0.13 0.89 0.12 WDR5 0.46 0.65 0.08 0.62 0.16 CDH7 0.46 1.29 0.20 1.28 0.27 TNFRSF9 0.46 1.34 0.14 1.36 0.27 HOXD12 0.46 1.15 0.22 1.34 0.36 VCX2 0.46 1.34 0.26 1.57 0.33 TPRN 0.46 0.59 0.19 0.55 0.22 NPHS1 0.45 0.92 0.29 1.15 0.20 L6 0.45 0.87 0.16 0.92 0.12 MAPK10 0.45 1.07 0.33 1.21 0.21 EXOG 0.45 1.24 0.38 1.41 0.35 PLEKHS1 0.45 0.79 0.20 0.88 0.21 CST4 0.44 0.49 0.13 0.61 0.16 GLDN 0.44 0.85 0.14 1.03 0.23 SOX6 0.44 0.88 0.14 0.78 0.21 SLC25A1 0.44 0.63 0.12 0.65 0.19 KCNC3 0.44 0.54 0.15 0.63 0.12 XKR3 0.44 1.43 0.31 1.49 0.44 ESRRA 0.44 0.82 0.13 0.99 0.15 CCR4 0.44 0.73 0.11 0.96 0.14 TUBGCP4 0.44 0.85 0.13 1.06 0.21 GIF 0.44 0.78 0.15 1.06 0.14 CHRM4 0.44 0.39 0.10 0.45 0.12 TIMP3 0.44 0.34 0.08 0.39 0.10 KCNJ2 0.43 0.51 0.10 0.57 0.12 AANAT 0.43 0.87 0.07 0.98 0.18 RPL35 0.43 0.79 0.28 0.98 0.19 CRABP2 0.43 1.14 0.19 1.20 0.15 POLR2I 0.43 1.10 0.12 0.95 0.21 ASNS 0.43 1.50 0.18 1.53 0.23 NME1-NME2 0.43 1.27 0.64 1.14 0.45 PVRL4 0.42 1.49 0.19 1.49 0.26 M6PR 0.42 0.58 0.10 0.66 0.18 CASQ1 0.42 0.99 0.15 0.96 0.15 LOC100132705 0.42 0.29 0.08 0.30 0.11 UBE2C 0.42 0.58 0.37 0.70 0.35 PPAPDC1B 0.42 0.88 0.13 0.92 0.16 GHRHR 0.42 0.63 0.19 0.68 0.11 TEFM 0.42 0.47 0.44 0.59 0.52 KCNE1 0.42 1.04 0.35 1.13 0.40 PDE6H 0.42 1.47 0.86 1.53 0.71 GATSL2 0.42 0.69 0.13 0.83 0.15 LPAR2 0.42 0.63 0.14 0.88 0.30 FBXO6 0.42 0.44 0.11 0.46 0.12 GYS1 0.41 0.25 0.07 0.29 0.08 CD8A 0.41 1.15 0.27 1.24 0.16 RGS8 0.41 1.66 0.34 1.91 0.56 HFE2 0.41 0.65 0.16 0.73 0.16 MAOA 0.41 0.84 0.16 0.95 0.15 RBFOX2 0.41 0.79 0.18 0.89 0.11 GFOD2 0.41 0.94 0.14 1.12 0.15 ZNF625 0.40 1.03 0.17 1.18 0.19 WNT7B 0.40 0.87 0.11 0.93 0.16

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PLK1 0.40 0.14 0.05 0.19 0.09 RHAG 0.40 0.98 0.10 0.99 0.17 NEDD8 0.40 0.83 0.22 1.05 0.15 GCG 0.40 0.15 0.05 0.16 0.08 FZD5 0.39 1.01 0.13 0.91 0.14 FTL 0.39 1.51 0.21 1.40 0.19 GK 0.39 1.01 0.16 1.16 0.24 ZNF321P 0.39 1.16 0.20 1.27 0.23 ZNF783 0.38 0.83 0.15 0.84 0.20 INHBA 0.38 0.87 0.11 0.78 0.13 RPS2 0.38 1.28 0.20 1.24 0.14 LUZP1 0.38 0.75 0.22 0.79 0.12 KPNA4 0.38 0.61 0.22 0.69 0.12 CPEB2 0.37 0.37 0.14 0.44 0.15 DEFB132 0.37 0.67 0.17 0.72 0.16 NPB 0.37 0.56 0.13 0.52 0.14 RPS14 0.37 0.47 0.12 0.45 0.13 CCR10 0.37 0.72 0.16 0.66 0.17 GARS 0.37 0.73 0.12 0.78 0.12 S1PR1 0.37 1.30 0.23 1.53 0.19 EDNRA 0.37 0.51 0.13 0.54 0.12 KRTAP10-12 0.37 0.74 0.20 0.78 0.17 ORC4 0.37 1.04 0.26 1.03 0.23 MAP3K13 0.36 1.06 0.20 1.05 0.20 TMEM132B 0.36 3.69 1.48 4.51 1.16 HNRNPA1L2 0.36 1.09 0.20 1.10 0.16 CCDC158 0.36 1.60 0.46 1.64 0.39 SEPW1 0.35 0.91 0.12 0.82 0.15 GPR55 0.35 0.76 0.14 0.65 0.15 SUDS3 0.35 1.50 0.25 1.26 0.19 PIGF 0.35 1.37 0.24 1.00 0.24 EMC10 0.35 1.25 0.35 1.14 0.33 SULT1C4 0.35 0.09 0.06 0.14 0.13 CFAP57 0.35 0.19 0.13 0.25 0.16 GPR1 0.35 0.10 0.09 0.10 0.08 RNF214 0.35 0.46 0.20 0.45 0.25 PMPCB 0.35 0.88 0.18 1.12 0.46 SLC5A3 0.35 0.46 0.16 0.65 0.30 MCEE 0.35 0.08 0.07 0.17 0.13 COX7A2 0.35 0.66 0.21 0.78 0.20 RPL31 0.34 0.72 0.20 0.89 0.23 LCOR 0.34 0.81 0.17 1.00 0.22 POLB 0.34 0.84 0.82 1.10 0.98 HES1 0.34 0.75 0.11 0.88 0.20 FAM27E3 0.34 0.83 0.17 0.90 0.18 CREG1 0.34 1.27 0.17 1.47 0.19 FFAR2 0.34 0.27 0.08 0.40 0.15 CADPS 0.33 0.25 0.07 0.38 0.19 SELT 0.33 0.16 0.07 0.25 0.13 PDE7B 0.33 0.42 0.13 0.60 0.27 NSMCE4A 0.33 1.16 0.37 1.47 0.59 PIAS4 0.32 1.30 0.37 1.54 0.61 NRBP1 0.32 0.68 0.09 0.77 0.17 BLOC1S1 0.32 1.79 0.31 1.85 0.41 PEF1 0.32 1.19 0.22 1.26 0.21 RAB37 0.32 1.21 0.26 1.19 0.14 ECI1 0.32 1.44 0.21 1.43 0.31 GPR17 0.32 1.14 0.12 1.15 0.23

Camacho-Encina M, et al. Ann Rheum Dis 2019; 0:1699ÿý1705. doi: 10.1136/annrheumdis-2019-215325 Supplementary material Ann Rheum Dis

APOA1BP 0.32 0.50 0.06 0.43 0.17 LSM14B 0.32 0.35 0.13 0.47 0.24 LCK 0.31 0.02 0.06 0.09 0.12 CAMK2D 0.31 0.04 0.05 0.09 0.11 EIF5A2 0.31 -0.01 0.04 0.02 0.06 NUP214 0.31 0.42 0.22 0.57 0.21 SETD3 0.30 -0.03 0.03 0.04 0.09 IKBKG 0.30 -0.03 0.03 0.06 0.12 AMN1 0.30 0.09 0.09 0.19 0.17 TNFSF18 0.30 0.04 0.06 0.04 0.07 GAGE12F 0.30 0.82 0.80 0.83 0.83 CCND1 0.30 0.66 0.52 0.69 0.46 PIP4K2B 0.29 0.29 0.13 0.42 0.21 RAB3IP 0.29 0.37 0.58 0.39 0.65 SRPK2 0.29 0.02 0.07 0.07 0.09 C2orf54 0.29 -0.02 0.02 0.01 0.05 PARP1 0.29 0.09 0.09 0.12 0.10 IRAK4 0.29 0.47 0.50 0.64 0.69 RPL28 0.29 0.40 0.43 0.61 0.45 MARCKSL1 0.29 0.79 0.12 0.90 0.32 AEBP2 0.29 0.07 0.07 0.16 0.13 PDCD4 0.29 0.29 0.31 0.37 0.40 CCL4 0.28 0.08 0.06 0.02 0.05 NPY4R 0.28 0.32 0.14 0.33 0.13 FAM117B 0.28 1.03 0.73 1.04 0.66 UBR7 0.28 0.90 0.23 1.20 0.52 GPR108 0.28 0.84 0.20 0.97 0.22 IFRD2 0.27 0.45 0.30 0.40 0.12 SCARB1 0.27 1.82 0.42 1.98 0.53 ITGB5 0.27 0.90 0.29 1.06 0.23 CHRM1 0.27 0.40 0.13 0.46 0.13 FAM156A 0.27 0.00 0.04 0.09 0.10 CLDN11 0.27 0.78 0.18 1.01 0.22 PIK3R1 0.27 0.07 0.07 0.11 0.11 SOAT2 0.27 0.80 0.18 0.92 0.30 CLDN5 0.27 1.75 0.40 2.13 0.65 TMEM26 0.26 0.96 0.29 1.02 0.24 RPL22 0.26 0.13 0.07 0.23 0.09 IKBKE 0.26 1.24 0.52 1.61 0.61 PLEKHG5 0.26 0.67 0.15 0.89 0.18 TMEM165 0.26 0.40 0.13 0.37 0.19 UBE2W 0.26 2.09 0.53 2.36 0.70 CHMP6 0.26 1.14 0.27 1.32 0.29 MED22 0.26 0.62 0.11 0.69 0.24 Empty+Master 0.26 0.60 0.20 0.89 0.39 FMO4 0.26 0.03 0.05 0.05 0.06 PHKG2 0.26 1.34 0.32 1.43 0.22 FAM25BP 0.26 1.25 0.24 1.31 0.23 MAP4K5 0.25 2.75 0.67 2.70 0.72 SMAD1 0.25 2.74 0.62 2.45 0.61 KLC1 0.25 0.72 0.61 0.77 0.61 KRTAP4-11 0.25 1.28 0.23 1.46 0.52 EPHA2 0.25 0.69 0.11 0.81 0.19 PIP5K1B 0.25 1.16 0.27 1.24 0.28 CCR8 0.24 1.71 0.45 1.91 0.58 SPINK9 0.24 0.91 0.29 1.18 0.21 CCL2 0.24 0.85 0.29 1.00 0.24 CT45A10 0.24 0.77 0.21 1.02 0.29

Camacho-Encina M, et al. Ann Rheum Dis 2019; 0:1699ÿý1705. doi: 10.1136/annrheumdis-2019-215325 Supplementary material Ann Rheum Dis

CCDC169 0.24 1.01 0.28 1.48 0.67 FERMT1 0.24 0.54 0.10 0.62 0.18 ADRA2B 0.24 0.40 0.11 0.45 0.21 FAM166B 0.24 0.71 0.13 0.83 0.18 ARHGAP27 0.24 1.11 0.22 1.35 0.21 SLC22A4 0.24 0.86 0.18 0.95 0.21 SELM 0.23 0.85 0.19 0.92 0.21 MOCS3 0.23 1.15 0.29 1.31 0.25 NDUFC1 0.23 1.98 0.48 2.33 0.51 PAK6 0.23 1.28 0.45 1.26 0.56 ADORA3 0.23 1.45 0.56 1.42 0.67 MBP 0.23 1.75 0.34 1.69 0.58 CLK3 0.23 1.34 0.17 1.41 0.26 HNRNPU 0.23 0.99 0.12 1.11 0.21 NGRN 0.22 1.35 0.27 1.36 0.25 OR6C2 0.22 1.05 0.15 1.18 0.19 COL20A1 0.22 1.60 0.26 1.66 0.20 DIO1 0.22 0.82 0.08 0.76 0.13 AP5B1 0.22 1.23 0.21 1.15 0.19 ITGA9 0.22 0.99 0.24 1.22 0.31 SPATC1L 0.22 1.15 0.28 1.42 0.41 RPS21 0.22 1.61 0.48 1.59 0.54 LRRD1 0.22 1.20 0.29 1.25 0.33 TMEM190 0.22 0.56 0.14 0.58 0.15 TSPY8 0.22 0.67 0.23 0.82 0.28 CCDC102B 0.22 0.82 0.22 0.95 0.25 BOLA2B 0.22 0.85 0.21 1.08 0.27 TLE6 0.22 0.52 0.20 0.62 0.16 NUP210 0.22 0.85 0.22 0.93 0.22 IFITM3 0.22 1.48 0.35 1.69 0.38 SLC17A8 0.21 1.55 0.35 1.76 0.31 ZNF512 0.21 1.66 0.34 1.92 0.40 Master Mix 0.21 1.26 0.45 1.13 0.21 COG8 0.21 1.19 0.32 1.46 0.32 TPM2 0.21 1.45 0.39 1.60 0.39 03/03/2015 0.21 1.60 0.40 1.68 0.46 BOLA2 0.21 0.94 0.18 0.79 0.17 CTSG 0.20 0.78 0.19 0.81 0.23 SLC12A1 0.20 1.15 0.17 1.29 0.27 PRELP 0.20 0.83 0.22 0.82 0.12 ZNF548 0.20 0.41 0.05 0.37 0.08 HEATR5A 0.20 0.96 0.09 1.00 0.19 SLC16A7 0.20 0.96 0.21 0.89 0.19 XCL2 0.19 1.43 0.22 1.50 0.34 FGFR4 0.19 2.11 0.68 1.71 0.75 U2AF1 0.19 1.08 0.37 1.14 0.42 FAM25A 0.19 0.80 0.20 0.99 0.28 ALG9 0.19 1.24 0.39 1.24 0.42 CKAP5 0.19 1.29 0.33 1.48 0.50 BMPR1A 0.19 0.54 0.15 0.60 0.23 HIST1H2BH 0.19 0.69 0.21 0.82 0.18 PKM 0.19 1.09 0.41 1.23 0.45 COX7C 0.18 0.61 0.19 0.73 0.19 C4orf29 0.18 0.76 0.26 1.07 0.29 C19orf66 0.18 1.13 0.27 1.42 0.44 CASQ2 0.18 1.16 0.24 1.27 0.20 HTATIP2 0.18 1.02 0.18 1.11 0.18 RING1 0.18 1.30 0.28 1.59 0.37

Camacho-Encina M, et al. Ann Rheum Dis 2019; 0:1699ÿý1705. doi: 10.1136/annrheumdis-2019-215325 Supplementary material Ann Rheum Dis

ICOS 0.18 1.43 0.55 1.68 0.39 PDGFRA 0.18 0.29 0.10 0.40 0.14 FBXL17 0.18 0.50 0.18 0.61 0.13 MLST8 0.18 1.69 0.36 1.79 0.61 SUCLG2 0.18 1.10 0.17 1.15 0.22 CTGF 0.18 0.93 0.12 1.01 0.15 EFHD2 0.17 1.03 0.19 0.93 0.20 H2AFB2 0.17 1.18 0.17 1.27 0.21 TRAFD1 0.17 1.69 0.39 1.80 0.32 HADHA 0.17 1.16 0.21 1.10 0.14 CXXC4 0.17 1.40 0.33 1.16 0.24 SRSF1 0.17 1.21 0.16 1.16 0.20 SRP14 0.17 0.79 0.08 0.72 0.26 IL10RB 0.17 0.94 0.26 1.14 0.33 HNRNPA1 0.17 0.82 0.15 0.84 0.24 SRSF2 0.17 0.68 0.16 0.68 0.20 GABRP 0.16 0.77 0.17 0.73 0.19 NFIX 0.16 1.07 0.27 1.10 0.29 ZNF45 0.16 0.71 0.23 0.84 0.24 ADCYAP1R1 0.16 0.75 0.28 0.86 0.14 ADK 0.16 1.21 0.30 1.25 0.29 SUMO2 0.16 0.19 0.07 0.24 0.12 AURKA 0.16 0.95 0.23 0.92 0.20 HAGH 0.16 3.00 1.13 3.90 1.36 GABRA4 0.16 0.94 0.17 1.15 0.10 EIF2S3 0.16 0.58 0.18 0.59 0.16 SEC31B 0.16 1.05 0.23 1.15 0.20 CSF1 0.15 0.61 0.19 0.59 0.14 PHKA2 0.15 0.98 0.22 0.98 0.18 STPG1 0.15 1.20 0.25 1.09 0.22 ZNF454 0.15 0.64 0.30 0.44 0.23 ATP5B 0.15 0.99 0.19 1.01 0.15 HLA-DRA 0.15 1.44 0.23 1.47 0.31 TAF13 0.15 1.02 0.19 0.89 0.21 INTS4 0.15 1.49 0.27 1.36 0.21 TBC1D16 0.15 1.48 0.26 1.22 0.19 KIAA1324 0.15 1.63 0.28 1.29 0.27 AK9 0.15 0.12 0.08 0.21 0.14 FANCF 0.15 0.24 0.11 0.36 0.21 HYI 0.15 0.51 0.24 0.59 0.34 PLAU 0.15 0.17 0.15 0.17 0.19 MACROD1 0.14 0.13 0.06 0.23 0.16 RNASEK 0.14 0.00 0.04 0.06 0.10 ZBTB37 0.14 0.05 0.05 0.13 0.12 CERS3 0.14 0.06 0.05 0.14 0.14 PTPRR 0.14 0.40 0.14 0.60 0.34 LLPH 0.14 0.25 0.09 0.39 0.22 GPR19 0.14 0.45 0.14 0.69 0.29 GPX2 0.14 0.91 0.86 1.06 1.13 DLX6 0.14 0.31 0.10 0.40 0.16 CAMKK1 0.14 0.98 0.78 0.92 0.72 ZNF451 0.14 0.06 0.08 0.15 0.14 RNF24 0.14 0.69 0.24 0.91 0.38 FAM72A 0.14 0.87 0.26 1.06 0.42 CCDC28A 0.14 0.70 0.23 0.74 0.27 KRTAP21-1 0.14 0.18 0.09 0.26 0.14 IFNAR1 0.14 0.20 0.19 0.28 0.22 UBE2U 0.14 0.27 0.10 0.31 0.14

Camacho-Encina M, et al. Ann Rheum Dis 2019; 0:1699ÿý1705. doi: 10.1136/annrheumdis-2019-215325 Supplementary material Ann Rheum Dis

FGFR1 0.13 0.08 0.05 0.13 0.11 PCDHGB1 0.13 0.26 0.11 0.28 0.10 ENO2 0.13 1.86 0.52 1.72 0.50 PKLR 0.13 0.82 0.29 0.83 0.38 NUP62 0.12 0.03 0.05 0.04 0.06 HS2ST1 0.12 0.01 0.03 0.02 0.06 SRSF10 0.12 -0.01 0.03 0.01 0.06 PSMD8 0.12 -0.04 0.03 -0.01 0.04 MLH1 0.12 0.01 0.04 0.05 0.06 CHEK2 0.12 -0.01 0.04 0.02 0.07 CUTA 0.12 0.31 0.16 0.37 0.17 SEC14L4 0.12 0.17 0.13 0.19 0.09 NDUFV2 0.12 0.34 0.13 0.37 0.15 GTF2A1L 0.12 0.01 0.05 0.03 0.07 ZNF80 0.12 0.92 0.19 1.14 0.38 LAPTM4B 0.11 0.52 0.25 0.63 0.34 PTK2 0.11 0.83 0.24 1.12 0.45 CENPK 0.11 -0.01 0.03 0.03 0.07 SNRPN 0.11 0.03 0.04 0.02 0.06 RFESD 0.11 0.03 0.05 0.01 0.06 THNSL1 0.11 0.06 0.05 0.02 0.05 S100A13 0.11 0.25 0.14 0.32 0.17 FRMPD2 0.11 0.00 0.02 0.01 0.06 CCDC153 0.11 0.85 0.42 0.92 0.51 NME1 0.11 1.84 0.53 1.87 0.48 LAGE3 0.11 0.36 0.16 0.48 0.26 PDK1 0.11 0.17 0.11 0.23 0.12 MIER1 0.10 0.48 0.18 0.46 0.24 GCK 0.10 1.80 1.17 1.65 1.05 ASB12 0.10 2.05 0.60 2.17 0.65 PRMT6 0.10 -0.01 0.04 0.04 0.06 TMIGD3 0.10 0.09 0.08 0.15 0.12 LCE3D 0.10 0.18 0.08 0.21 0.13 RPL32 0.10 0.17 0.07 0.27 0.24 ELMOD1 0.10 1.26 0.41 1.64 0.49 MIPOL1 0.10 0.91 0.37 1.03 0.34 GPIHBP1 0.10 0.69 0.23 0.89 0.33 PLSCR2 0.10 0.31 0.39 0.37 0.54 CHMP3 0.10 0.76 0.15 0.87 0.24 SDS 0.10 0.78 0.15 1.03 0.29 IRF3 0.09 0.79 0.17 0.95 0.32 TUBB 0.09 1.03 0.15 1.10 0.26 CMTM3 0.09 0.02 0.06 0.00 0.05 RPS6KA2 0.09 0.13 0.15 0.19 0.14 H2AFX 0.09 0.15 0.09 0.21 0.15 HIST1H1D 0.09 0.08 0.08 0.12 0.10 SMR3B 0.09 0.13 0.09 0.18 0.18 CDH20 0.09 0.14 0.08 0.16 0.13 TGIF2 0.09 0.69 0.23 0.64 0.23 P2RX7 0.09 1.85 0.84 1.97 1.01 STK11 0.09 2.46 0.88 2.60 0.81 TMEM230 0.09 1.34 0.19 1.40 0.21 HMOX2 0.09 0.61 0.09 0.54 0.12 IFNA7 0.09 0.81 0.09 0.80 0.27 C9orf135 0.08 1.17 0.15 1.15 0.23 CDK2 0.08 1.37 0.24 1.43 0.33 MGAT3 0.08 0.35 0.14 0.51 0.25 SCARA3 0.08 -0.04 0.03 -0.01 0.04

Camacho-Encina M, et al. Ann Rheum Dis 2019; 0:1699ÿý1705. doi: 10.1136/annrheumdis-2019-215325 Supplementary material Ann Rheum Dis

KRT6A 0.08 0.58 0.18 0.87 0.57 AXL 0.08 0.44 0.23 0.51 0.29 CCL3L3 0.08 1.15 0.41 1.43 0.62 FAF1 0.08 0.66 0.36 0.82 0.51 PRR5-ARHGAP 0.08 0.60 0.18 0.72 0.21 C15orf27 0.08 0.57 0.15 0.76 0.25 PRR13 0.08 0.84 0.15 1.09 0.30 TMEM126B 0.08 0.18 0.11 0.23 0.13 CCL3L1 0.07 0.95 0.16 1.14 0.31 ANKRD13D 0.07 0.79 0.11 0.95 0.17 PAPSS1 0.07 0.17 0.09 0.20 0.10 SLC6A6 0.07 0.31 0.13 0.39 0.20 CLEC17A 0.07 2.19 0.65 2.36 0.60 C17orf104 0.07 1.79 0.59 2.14 0.74 C11orf68 0.07 1.30 0.41 1.40 0.35 HRH1 0.07 1.18 0.52 1.14 0.45 ITGB3BP 0.07 0.21 0.09 0.27 0.16 CKM 0.07 0.68 0.16 0.67 0.27 NPPC 0.07 1.15 0.17 1.21 0.24 CDK4 0.07 1.01 0.14 1.07 0.20 SNRPB 0.06 0.92 0.11 0.93 0.11 SMYD2 0.06 0.07 0.03 0.09 0.11 KRT5 0.06 0.70 0.07 0.65 0.23 MTA3 0.06 0.31 0.10 0.27 0.14 LRP5L 0.06 0.82 0.25 1.07 0.32 MAP2K2 0.06 0.63 0.23 0.98 0.40 SHMT2 0.06 0.42 0.19 0.46 0.21 UGGT2 0.06 0.32 0.10 0.38 0.20 TRIP10 0.06 0.62 0.19 0.69 0.24 SLC25A29 0.06 0.63 0.30 0.66 0.27 VCX3A 0.06 0.84 0.20 1.00 0.39 OSTCP1 0.06 0.55 0.19 0.62 0.23 PLA2G10 0.06 0.73 0.16 0.93 0.26 ARL6IP4 0.06 0.92 0.27 1.06 0.36 PPP1R11 0.06 0.69 0.23 0.72 0.20 MCMDC2 0.05 0.63 0.19 0.74 0.21 PRKCZ 0.05 0.68 0.21 0.82 0.27 L4 0.05 0.48 0.15 0.58 0.20 BAIAP2 0.05 0.78 0.29 0.90 0.29 DLK2 0.05 1.20 0.39 1.23 0.40 L3 0.05 0.40 0.08 0.39 0.15 MBOAT7 0.05 0.62 0.12 0.58 0.14 KCNJ15 0.05 0.63 0.18 0.59 0.11 TRIM44 0.05 1.20 0.22 1.31 0.29 DCAF16 0.05 0.97 0.14 0.97 0.22 NDFIP2 0.05 1.02 0.18 0.91 0.27 CAMK4 0.05 1.09 0.08 1.00 0.21 PLA2G12A 0.05 1.16 0.13 1.15 0.28 ZNF524 0.04 1.05 0.29 0.94 0.25 VAMP3 0.04 1.63 0.40 1.75 0.48 TRIM4 0.04 0.65 0.24 0.96 0.38 RIPPLY1 0.04 0.51 0.15 0.64 0.24 L1 0.04 0.56 0.16 0.70 0.26 ZSCAN31 0.04 0.80 0.23 1.00 0.36 HIGD1A 0.04 0.39 0.13 0.43 0.21 KCNJ4 0.04 0.77 0.25 0.88 0.29 CHAC1 0.04 0.03 0.05 0.10 0.11 PDK4 0.04 0.49 0.16 0.62 0.19

Camacho-Encina M, et al. Ann Rheum Dis 2019; 0:1699ÿý1705. doi: 10.1136/annrheumdis-2019-215325 Supplementary material Ann Rheum Dis

L2 0.04 0.56 0.17 0.70 0.30 LOC400927-CS 0.04 0.79 0.29 0.88 0.42 GFER 0.04 0.52 0.16 0.54 0.19 ZMAT1 0.04 0.40 0.12 0.42 0.15 PRPS1 0.04 0.90 0.33 0.96 0.42 KCTD15 0.03 0.95 0.20 1.04 0.28 L5 0.03 0.56 0.25 0.65 0.18 MAP2K7 0.03 0.80 0.17 0.83 0.30 MAPK3 0.03 0.63 0.15 0.63 0.22 WNK1 0.03 0.70 0.15 0.62 0.13 Nonspot 0.03 0.57 0.15 0.46 0.11 PGAM1 0.03 1.64 0.64 1.51 0.50 FBXL18 0.03 0.89 0.13 0.88 0.28 PAK7 0.03 1.34 0.70 1.24 0.55 PRKACG 0.03 0.93 0.13 0.83 0.21 TNK1 0.03 2.02 0.61 1.83 0.57 MYH9 0.02 1.67 0.43 1.52 0.45 CDYL 0.02 2.66 1.08 2.47 1.11 CAMK2G 0.02 0.48 0.21 0.66 0.27 TYK2 0.02 0.61 0.27 0.79 0.28 GAL3ST1 0.02 0.63 0.25 0.78 0.27 SOCS3 0.02 0.65 0.25 0.81 0.29 POLR3H 0.02 0.83 0.32 1.06 0.37 TAP1 0.02 0.04 0.06 0.02 0.03 VTCN1 0.02 0.46 0.17 0.56 0.23 FUS 0.01 0.66 0.24 0.77 0.26 CMPK1 0.01 0.50 0.19 0.53 0.19 SNRPD3 0.01 0.84 0.37 0.87 0.40 SPHK2 0.01 0.87 0.28 0.84 0.26 WDR48 0.01 0.25 0.38 0.27 0.40 ZNF350 0.01 0.81 0.22 0.87 0.17 EIF4A1 0.01 0.51 0.19 0.55 0.13 BLOC1S5-TXND 0.01 0.77 0.25 0.78 0.14 CKMT1B 0.01 0.28 0.14 0.25 0.09 APOA1 0.00 0.82 0.25 0.75 0.10 GPN3 0.00 0.75 0.25 0.78 0.19 NME6 0.00 2.48 1.30 3.21 1.42 SZRD1 0.00 0.65 0.16 0.56 0.12 USP18 -0.01 1.64 0.52 1.45 0.44 PITPNB -0.02 0.87 0.19 0.75 0.19 MFNG -0.02 1.08 0.26 0.85 0.19 MCM5 -0.02 1.59 0.37 1.35 0.39 ASCL1 -0.03 2.91 1.46 2.18 1.04 MAPK12 -0.03 4.98 2.07 3.51 1.73

Camacho-Encina M, et al. Ann Rheum Dis 2019; 0:1699ÿý1705. doi: 10.1136/annrheumdis-2019-215325 Supplementary material Ann Rheum Dis

Supplementary Table S4. Candidate autoantibodies identified in the screening phase of the present study. p value Wilcoxon Specificity at Protein name Symbol AUC test 95% sensitivity Ankyrin repeat and SOCS box protein 7 ASB7 0.002 77 0.88 Methionine adenosyltransferase 2 subunit beta MAT2b 0.005 81 0.86 Diphosphomevalonate decarboxylase MVD 0.002 76 0.9 Ras-related C3 botulinum toxin substrate 3 RAC3 0.003 76 0.88 UDP-glucuronosyltransferase 1-7 UGT1A7 0.015 80 0.82 Vacuolar protein sorting-associated protein 4B VPS4B 0.005 81 0.85

AUC, Area Under the Curve

Camacho-Encina M, et al. Ann Rheum Dis 2019; 0:1699ÿý1705. doi: 10.1136/annrheumdis-2019-215325 Supplementary material Ann Rheum Dis

Supplementary Table S5. Univariable logistic regression analysis for all the selected predictors in the verification phase. Covariates p value OR 95% CI Age, years 0.000 1.06 (1.03–1.08) Sex, female 0.048 1.58 (1.01–2.49) BMI, Kg/m2 0.000 1.17 (1.11–1.24) Observe obvious hard bumps on joints closest to fingertips, yes 0.000 2.46 (1.49–4.05) Hard bumps on fingers 0.002 right hand vs no bumps 0.387 1.46 (0.62–3.45) left hand vs no bumps 0.573 1.59 (0.32–8.07) both hands vs no bumps 0.000 3.19 (1.75–5.79) Right hand exam: total number of bony enlargements 0.001 1.26 (1.10–1.45) Left hand exam: total number of bony enlargements 0.001 1.31 (1.12–1.52) Family history of knee replacement, yes 0.141 1.67 (0.84–3.30) Frequent knee bending activity, yes 0.002 2.20 (1.35–3.58) Physical Activity Scale for the Elderly score 0.651 1.00 (1.00–1.00) History of knee injury, yes 0.001 2.57 (1.45–4.55) History of knee surgery, yes 0.060 1.95 (0.97–3.92) WOMAC Total Score 0.000 1.10 (1.06–1.13) WOMAC Disability Score 0.000 1.13 (1.08–1.19) WOMAC Stiffness Score 0.000 1.64 (1.36–1.98) WOMAC Pain Score 0.000 1.35 (1.17–1.56) KOOS Symptoms Score 0.000 0.94 (0.92–0.97) KOOS Pain Score 0.000 0.94 (0.92–0.96)

Values in bold represent associations of p≤0.05 BMI, Body Mass Index; WOMAC, Western Ontario and McMaster Universities Osteoarthritis Index; KOOS, Knee injury and Osteoarthritis Outcome Score.

Camacho-Encina M, et al. Ann Rheum Dis 2019; 0:1699ÿý1705. doi: 10.1136/annrheumdis-2019-215325