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mediated cytotoxicity ( with data)

HLA−B KIR3DL1 HLA−A KIR3DL2 HLA−G PTPN6 HLA−B KIR2DL1 KLRD1 PTPN11 PTK2B KLRC1 −p ITGAL HLA−C KLRD1 −p ICAM1 ITGB2 HLA−E −p −p ICAM1 ITGAL VAV3... RAC1 ITGB2 KLRD1 KIR2DS2 SH3BP2 LCK C05981 KLRC2 +p K06856FCGR3A KLRD1TYROBP LCP2PLCG1 NCR1 +p+p LAT NCR2 ZAP70+p +p +p PIK3R5 PAK1 SYK +p RAET1E KLRC4−KLRK1... Apoptosis NCR1 +pFYN +p MAPK signaling pathwayMAP2K1 FCGR3AFCER1G+p +p K06856 CD247 +p +p NCR3 SHC2 GRB2 SOS1 HRAS ARAF MICA MAPK1 TNF MICB KLRC4−KLRK1...HCST −p ULBP3 LAT PLCG1C01245C00076PPP3CANFATC1 CSF2 SH2D1B C00165 PRKCA IFNG CD48 CD244 SH2D1A +p FYN Calcium signaling pathway IFNGR1 Cytokine−cytokine receptor interaction Jak−STAT signaling IFNA1IFNAR1 TNFSF10 pathway TNFRSF10D TNFSF10 FAS FASLG CASP3 PRF1 FASLG GZMB GZMB BID PRF1 PRF1 Natural killer cell mediated cytotoxicity (sink nodes)

HLA−B KIR3DL1 HLA−A KIR3DL2 HLA−G PTPN6 HLA−B KIR2DL1 KLRD1 PTPN11 PTK2B KLRC1 −p ITGAL HLA−C KLRD1 −p ICAM1 ITGB2 HLA−E −p −p ICAM1 ITGAL VAV3... RAC1 ITGB2 KLRD1 KIR2DS2 SH3BP2 LCK C05981 KLRC2 +p K06856FCGR3A KLRD1TYROBP LCP2PLCG1 NCR1 +p+p LAT NCR2 ZAP70+p +p +p PIK3R5 PAK1 SYK +p RAET1E KLRC4−KLRK1... Apoptosis NCR1 +pFYN +p MAPK signaling pathwayMAP2K1 FCGR3AFCER1G+p +p K06856 CD247 +p +p NCR3 SHC2 GRB2 SOS1 HRAS ARAF MICA MAPK1 TNF MICB KLRC4−KLRK1...HCST −p ULBP3 LAT PLCG1C01245C00076PPP3CANFATC1 CSF2 SH2D1B C00165 PRKCA IFNG CD48 CD244 SH2D1A +p FYN Calcium signaling pathway IFNGR1 Cytokine−cytokine receptor interaction Jak−STAT signaling IFNA1IFNAR1 TNFSF10 pathway TNFRSF10D TNFSF10 FAS FASLG CASP3 PRF1 FASLG GZMB GZMB BID PRF1 PRF1 Natural killer cell mediated cytotoxicity BL

HLA−B KIR3DL1 HLA−A KIR3DL2 HLA−G PTPN6 HLA−B KIR2DL1 KLRD1 PTPN11 PTK2B KLRC1 −p ITGAL HLA−C KLRD1 −p ICAM1 ITGB2 HLA−E −p −p ICAM1 ITGAL VAV3... RAC1 ITGB2 KLRD1 KIR2DS2 SH3BP2 LCK C05981 KLRC2 +p K06856FCGR3A KLRD1TYROBP LCP2PLCG1 NCR1 +p+p LAT NCR2 ZAP70+p +p +p PIK3R5 PAK1 SYK +p RAET1E KLRC4−KLRK1... Apoptosis NCR1 +pFYN +p MAPK signaling pathwayMAP2K1 FCGR3AFCER1G+p +p K06856 CD247 +p +p NCR3 SHC2 GRB2 SOS1 HRAS ARAF MICA MAPK1 TNF MICB KLRC4−KLRK1...HCST −p ULBP3 LAT PLCG1C01245C00076PPP3CANFATC1 CSF2 SH2D1B C00165 PRKCA IFNG CD48 CD244 SH2D1A +p FYN Calcium signaling pathway IFNGR1 Cytokine−cytokine receptor interaction Jak−STAT signaling IFNA1IFNAR1 TNFSF10 pathway TNFRSF10D TNFSF10 FAS FASLG CASP3 PRF1 FASLG GZMB GZMB BID PRF1 PRF1 Natural killer cell mediated cytotoxicity intermediate

HLA−B KIR3DL1 HLA−A KIR3DL2 HLA−G PTPN6 HLA−B KIR2DL1 KLRD1 PTPN11 PTK2B KLRC1 −p ITGAL HLA−C KLRD1 −p ICAM1 ITGB2 HLA−E −p −p ICAM1 ITGAL VAV3... RAC1 ITGB2 KLRD1 KIR2DS2 SH3BP2 LCK C05981 KLRC2 +p K06856FCGR3A KLRD1TYROBP LCP2PLCG1 NCR1 +p+p LAT NCR2 ZAP70+p +p +p PIK3R5 PAK1 SYK +p RAET1E KLRC4−KLRK1... Apoptosis NCR1 +pFYN +p MAPK signaling pathwayMAP2K1 FCGR3AFCER1G+p +p K06856 CD247 +p +p NCR3 SHC2 GRB2 SOS1 HRAS ARAF MICA MAPK1 TNF MICB KLRC4−KLRK1...HCST −p ULBP3 LAT PLCG1C01245C00076PPP3CANFATC1 CSF2 SH2D1B C00165 PRKCA IFNG CD48 CD244 SH2D1A +p FYN Calcium signaling pathway IFNGR1 Cytokine−cytokine receptor interaction Jak−STAT signaling IFNA1IFNAR1 TNFSF10 pathway TNFRSF10D TNFSF10 FAS FASLG CASP3 PRF1 FASLG GZMB GZMB BID PRF1 PRF1 Natural killer cell mediated cytotoxicity DLBCL

HLA−B KIR3DL1 HLA−A KIR3DL2 HLA−G PTPN6 HLA−B KIR2DL1 KLRD1 PTPN11 PTK2B KLRC1 −p ITGAL HLA−C KLRD1 −p ICAM1 ITGB2 HLA−E −p −p ICAM1 ITGAL VAV3... RAC1 ITGB2 KLRD1 KIR2DS2 SH3BP2 LCK C05981 KLRC2 +p K06856FCGR3A KLRD1TYROBP LCP2PLCG1 NCR1 +p+p LAT NCR2 ZAP70+p +p +p PIK3R5 PAK1 SYK +p RAET1E KLRC4−KLRK1... Apoptosis NCR1 +pFYN +p MAPK signaling pathwayMAP2K1 FCGR3AFCER1G+p +p K06856 CD247 +p +p NCR3 SHC2 GRB2 SOS1 HRAS ARAF MICA MAPK1 TNF MICB KLRC4−KLRK1...HCST −p ULBP3 LAT PLCG1C01245C00076PPP3CANFATC1 CSF2 SH2D1B C00165 PRKCA IFNG CD48 CD244 SH2D1A +p FYN Calcium signaling pathway IFNGR1 Cytokine−cytokine receptor interaction Jak−STAT signaling IFNA1IFNAR1 TNFSF10 pathway TNFRSF10D TNFSF10 FAS FASLG CASP3 PRF1 FASLG GZMB GZMB BID PRF1 PRF1 Natural killer cell mediated cytotoxicity FL/DLBCL

HLA−B KIR3DL1 HLA−A KIR3DL2 HLA−G PTPN6 HLA−B KIR2DL1 KLRD1 PTPN11 PTK2B KLRC1 −p ITGAL HLA−C KLRD1 −p ICAM1 ITGB2 HLA−E −p −p ICAM1 ITGAL VAV3... RAC1 ITGB2 KLRD1 KIR2DS2 SH3BP2 LCK C05981 KLRC2 +p K06856FCGR3A KLRD1TYROBP LCP2PLCG1 NCR1 +p+p LAT NCR2 ZAP70+p +p +p PIK3R5 PAK1 SYK +p RAET1E KLRC4−KLRK1... Apoptosis NCR1 +pFYN +p MAPK signaling pathwayMAP2K1 FCGR3AFCER1G+p +p K06856 CD247 +p +p NCR3 SHC2 GRB2 SOS1 HRAS ARAF MICA MAPK1 TNF MICB KLRC4−KLRK1...HCST −p ULBP3 LAT PLCG1C01245C00076PPP3CANFATC1 CSF2 SH2D1B C00165 PRKCA IFNG CD48 CD244 SH2D1A +p FYN Calcium signaling pathway IFNGR1 Cytokine−cytokine receptor interaction Jak−STAT signaling IFNA1IFNAR1 TNFSF10 pathway TNFRSF10D TNFSF10 FAS FASLG CASP3 PRF1 FASLG GZMB GZMB BID PRF1 PRF1 Natural killer cell mediated cytotoxicity FL

HLA−B KIR3DL1 HLA−A KIR3DL2 HLA−G PTPN6 HLA−B KIR2DL1 KLRD1 PTPN11 PTK2B KLRC1 −p ITGAL HLA−C KLRD1 −p ICAM1 ITGB2 HLA−E −p −p ICAM1 ITGAL VAV3... RAC1 ITGB2 KLRD1 KIR2DS2 SH3BP2 LCK C05981 KLRC2 +p K06856FCGR3A KLRD1TYROBP LCP2PLCG1 NCR1 +p+p LAT NCR2 ZAP70+p +p +p PIK3R5 PAK1 SYK +p RAET1E KLRC4−KLRK1... Apoptosis NCR1 +pFYN +p MAPK signaling pathwayMAP2K1 FCGR3AFCER1G+p +p K06856 CD247 +p +p NCR3 SHC2 GRB2 SOS1 HRAS ARAF MICA MAPK1 TNF MICB KLRC4−KLRK1...HCST −p ULBP3 LAT PLCG1C01245C00076PPP3CANFATC1 CSF2 SH2D1B C00165 PRKCA IFNG CD48 CD244 SH2D1A +p FYN Calcium signaling pathway IFNGR1 Cytokine−cytokine receptor interaction Jak−STAT signaling IFNA1IFNAR1 TNFSF10 pathway TNFRSF10D TNFSF10 FAS FASLG CASP3 PRF1 FASLG GZMB GZMB BID PRF1 PRF1 Natural killer cell mediated cytotoxicity other

HLA−B KIR3DL1 HLA−A KIR3DL2 HLA−G PTPN6 HLA−B KIR2DL1 KLRD1 PTPN11 PTK2B KLRC1 −p ITGAL HLA−C KLRD1 −p ICAM1 ITGB2 HLA−E −p −p ICAM1 ITGAL VAV3... RAC1 ITGB2 KLRD1 KIR2DS2 SH3BP2 LCK C05981 KLRC2 +p K06856FCGR3A KLRD1TYROBP LCP2PLCG1 NCR1 +p+p LAT NCR2 ZAP70+p +p +p PIK3R5 PAK1 SYK +p RAET1E KLRC4−KLRK1... Apoptosis NCR1 +pFYN +p MAPK signaling pathwayMAP2K1 FCGR3AFCER1G+p +p K06856 CD247 +p +p NCR3 SHC2 GRB2 SOS1 HRAS ARAF MICA MAPK1 TNF MICB KLRC4−KLRK1...HCST −p ULBP3 LAT PLCG1C01245C00076PPP3CANFATC1 CSF2 SH2D1B C00165 PRKCA IFNG CD48 CD244 SH2D1A +p FYN Calcium signaling pathway IFNGR1 Cytokine−cytokine receptor interaction Jak−STAT signaling IFNA1IFNAR1 TNFSF10 pathway TNFRSF10D TNFSF10 FAS FASLG CASP3 PRF1 FASLG GZMB GZMB BID PRF1 PRF1 Natural killer cell mediated cytotoxicity cell line

HLA−B KIR3DL1 HLA−A KIR3DL2 HLA−G PTPN6 HLA−B KIR2DL1 KLRD1 PTPN11 PTK2B KLRC1 −p ITGAL HLA−C KLRD1 −p ICAM1 ITGB2 HLA−E −p −p ICAM1 ITGAL VAV3... RAC1 ITGB2 KLRD1 KIR2DS2 SH3BP2 LCK C05981 KLRC2 +p K06856FCGR3A KLRD1TYROBP LCP2PLCG1 NCR1 +p+p LAT NCR2 ZAP70+p +p +p PIK3R5 PAK1 SYK +p RAET1E KLRC4−KLRK1... Apoptosis NCR1 +pFYN +p MAPK signaling pathwayMAP2K1 FCGR3AFCER1G+p +p K06856 CD247 +p +p NCR3 SHC2 GRB2 SOS1 HRAS ARAF MICA MAPK1 TNF MICB KLRC4−KLRK1...HCST −p ULBP3 LAT PLCG1C01245C00076PPP3CANFATC1 CSF2 SH2D1B C00165 PRKCA IFNG CD48 CD244 SH2D1A +p FYN Calcium signaling pathway IFNGR1 Cytokine−cytokine receptor interaction Jak−STAT signaling IFNA1IFNAR1 TNFSF10 pathway TNFRSF10D TNFSF10 FAS FASLG CASP3 PRF1 FASLG GZMB GZMB BID PRF1 PRF1 Natural killer cell mediated cytotoxicity B−cells

HLA−B KIR3DL1 HLA−A KIR3DL2 HLA−G PTPN6 HLA−B KIR2DL1 KLRD1 PTPN11 PTK2B KLRC1 −p ITGAL HLA−C KLRD1 −p ICAM1 ITGB2 HLA−E −p −p ICAM1 ITGAL VAV3... RAC1 ITGB2 KLRD1 KIR2DS2 SH3BP2 LCK C05981 KLRC2 +p K06856FCGR3A KLRD1TYROBP LCP2PLCG1 NCR1 +p+p LAT NCR2 ZAP70+p +p +p PIK3R5 PAK1 SYK +p RAET1E KLRC4−KLRK1... Apoptosis NCR1 +pFYN +p MAPK signaling pathwayMAP2K1 FCGR3AFCER1G+p +p K06856 CD247 +p +p NCR3 SHC2 GRB2 SOS1 HRAS ARAF MICA MAPK1 TNF MICB KLRC4−KLRK1...HCST −p ULBP3 LAT PLCG1C01245C00076PPP3CANFATC1 CSF2 SH2D1B C00165 PRKCA IFNG CD48 CD244 SH2D1A +p FYN Calcium signaling pathway IFNGR1 Cytokine−cytokine receptor interaction Jak−STAT signaling IFNA1IFNAR1 TNFSF10 pathway TNFRSF10D TNFSF10 FAS FASLG CASP3 PRF1 FASLG GZMB GZMB BID PRF1 PRF1 Natural killer cell mediated cytotoxicity tonsil

HLA−B KIR3DL1 HLA−A KIR3DL2 HLA−G PTPN6 HLA−B KIR2DL1 KLRD1 PTPN11 PTK2B KLRC1 −p ITGAL HLA−C KLRD1 −p ICAM1 ITGB2 HLA−E −p −p ICAM1 ITGAL VAV3... RAC1 ITGB2 KLRD1 KIR2DS2 SH3BP2 LCK C05981 KLRC2 +p K06856FCGR3A KLRD1TYROBP LCP2PLCG1 NCR1 +p+p LAT NCR2 ZAP70+p +p +p PIK3R5 PAK1 SYK +p RAET1E KLRC4−KLRK1... Apoptosis NCR1 +pFYN +p MAPK signaling pathwayMAP2K1 FCGR3AFCER1G+p +p K06856 CD247 +p +p NCR3 SHC2 GRB2 SOS1 HRAS ARAF MICA MAPK1 TNF MICB KLRC4−KLRK1...HCST −p ULBP3 LAT PLCG1C01245C00076PPP3CANFATC1 CSF2 SH2D1B C00165 PRKCA IFNG CD48 CD244 SH2D1A +p FYN Calcium signaling pathway IFNGR1 Cytokine−cytokine receptor interaction Jak−STAT signaling IFNA1IFNAR1 TNFSF10 pathway TNFRSF10D TNFSF10 FAS FASLG CASP3 PRF1 FASLG GZMB GZMB BID PRF1 PRF1