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(FDR<0.05) Enriched in the 1015 Genes Co-Clustered with Known T

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(FDR<0.05) Enriched in the 1015 Genes Co-Clustered with Known T Supplementary Table 3. Significant biological processes (FDR<0.05) enriched in the 1,015 genes co-clustered with known T cell gene signatures. Among 1,015 genes, 771 were associated with GO annotation in DAVID database v6.7. List Total: total number of genes in my list. Pop Hits: total number of genes associated with this GO term from the database. Pop Total: total number of genes in the database. Fold Enrichment: relative enrichment ratio, calculated by (Count)/(List Total) divided by (Pop Hits)/(Pop Total). Index Gene Ontology Accession Gene Ontology Name Count List Total Pop Hits Pop Total Fold Enrichment FDR Genes AQP9, C1QC, B2M, LILRA1, LILRA2, CLEC4E, S1PR4, LILRA4, IFNG, LILRA6, CLEC4A, VNN1, ERAP2, FAS, CRTAM, C5AR1, GBP5, NCF2, NCF1, NCF4, SERPING1, HLA-DQA2, HLA-DQA1, PDCD1LG2, LILRB1, CCR9, C1QA, C1QB, LILRB2, CCR7, CCR6, UNC13D, CCR5, CD40LG, CCR4, LILRB3, CCR2, LILRB4, HLA-DPA1, VSIG4, HLA-DRA, IL1R2, IL1R1, HLA-DRB1, OAS3, ACP5, OAS1, OAS2, CD74, IFI35, ZAP70, FCER1G, HLA-DRB5, HLA-DPB1, HLA-DOA, HLA-DOB, DHX58, BLNK, IL23R, KIR2DS4, CD300C, SLAMF7, OASL, RGS1, APOL1, CD300A, HMHB1, CD209, CLEC7A, LY86, LY9, CLNK, FCRL4, SH2D1A, NOD2, HAMP, CCL3L1, CCL3L3, TICAM2, ICAM1, GZMA, CMKLR1, LY96, WAS, IL18BP, LAX1, TNFSF12- TNFSF13, HLA-DQB1, CSF2, GPR183, CCR1, GPR65, CXCL9, NCF1C, IL7R, CLEC10A, CCL24, CCL22, CYP27B1, CCL23, FCGR1C, FTHL3, FCGR1A, FCGR1B, BCL3, C2, CD27, CD28, FYB, IL18R1, IL7, CD1C, CTLA4, CCL19, CD1B, CD1A, TRIM22, CD180, CD1E, CCL18, CCL17, CCL13, FCGR2B, FCGR2C, P2RY14, LIME1, CD14, IL16, IL18, TLR1, TNFSF15, TLR2, TNFSF14, TLR4, TNFSF13, TNFSF12, TLR5, 1 GO:0006955 immune response 266 771 690 13528 6.76413 6.86E-160 TLR6, CXCL11, TLR7, TLR8, IL10, CXCL10, TAPBP, TLR9, MS4A1, IL1B, EBI3, SPN, CIITA, HLA-H, POU2AF1, IL29, IL27, RELB, HLA-A, TNFRSF17, HLA-C, TNFRSF14, CCL4L2, HLA-B, HLA-E, TRAT1, HLA- F, IGSF6, LAT2, CST7, LYST, CD300LF, KIR2DL1, GBP4, KIR2DL3, GBP3, KIR3DL1, GBP2, GBP1, TNFAIP8L2, CCL1, ITGAL, IFIH1, CCL3, LST1, CYSLTR2, TFEB, IL32, CCL5, CCL4, FTH1, CHIT1, ICOS, ARHGDIB, TLR10, CARD9, IGJ, TNFRSF13B, TNFRSF13C, MYO1F, VAV1, AIM2, PSMB8, PSMB9, IKBKE, LAT, CORO1A, TNFSF10, FCAR, CXCL13, CXCL16, CD274, PLCG2, CD79B, ITGAD, CD79A, XCL1, XCL2, IFI6, KYNU, CD8A, CD8B, FASLG, IFI44L, HLA-DMB, HLA-DMA, SKAP1, PDCD1, CD96, LTF, LTB, LTA, LOC285830, LAIR1, SP100, IL18RAP, SIT1, PTGER4, SLA2, CTSS, NLRP3, FCAMR, CTSW, NCR3, OSM, BPI, CD86, TNFSF13B, FAIM3, CTSC, TREM2, PTAFR, LCP2, PSMB10, TNF, GPSM3, RSAD2, TNFRSF4, TNFRSF1B, TAP2, TAP1, POU2F2, FCN1, CD4, IL2RG, MR1, CD7, SECTM1, PTPRC, CR1, CR2, IL2RA, THEMIS, TNFSF8, CYBB, IRF8, ANXA11 KLRC4, KLRC2, KLRC3, AIF1, TLR1, TLR2, TLR4, TLR5, TLR6, CXCL11, TLR7, C1QC, IL10, TLR8, TAPBP, TLR9, CXCL10, CD48, LILRA1, LILRA2, CD44, IFNG, IL1B, CSF3R, VNN1, MX1, MX2, SPN, CIITA, C5AR1, NCF2, IL29, NCF1, IL27, GNLY, CST3, HLA-C, CCL4L2, SERPING1, HLA-B, CD40, SP140, TRAT1, CCR9, C1QA, C1QB, LILRB2, CCR7, UNC13D, CCR6, CCR5, CCR4, CD40LG, LYST, LILRB3, CCR2, MNDA, VSIG4, PLA2G2D, KIR3DL2, KIR2DL4, HLA-DRA, TNFAIP8L2, ITGAL, C3AR1, CCL3, IL1R1, IFIH1, CYSLTR1, FGR, IL32, ITGB2, CCL5, PTPRCAP, CCL4, CD74, LGALS3BP, DHX58, BLNK, TYROBP, ITK, TLR10, CARD9, IL23R, MYO1F, CD300C, CD5L, SLAMF7, APOL2, APOL3, P2RX7, CORO1A, APOL1, 2 GO:0006952 defense response 169 771 615 13528 4.82160 1.26E-70 P2RX1, CXCL13, CXCL16, CLEC7A, PLA2G4C, KYNU, LY86, SH2D1A, NOD2, CCL3L1, HAMP, AOAH, CCL3L3, TICAM2, LTF, HCP5, SERPINA1, XCR1, SP100, IL18RAP, LY96, CD160, LYZ, NFAM1, NLRP3, WAS, NLRP1, NCR3, CD84, SIGLEC1, BPI, PLA2G7, FAIM3, PTAFR, PRF1, TNF, CCR1, CXCL9, NCF1C, RSAD2, GPR68, FPR2, TNFRSF4, CCL24, CCL22, TNFRSF1B, CCL23, CYP27B1, FCGR1C, FCGR1A, TAP2, TAP1, BCL3, C2, TCIRG1, PTPRC, IL18R1, CR1, CR2, LIPA, IL2RA, HCK, RNASE6, CCL19, IDO1, COTL1, CD180, CCL18, CCL17, LSP1, KCNN4, ORM1, CCL13, CYBB, CD19, NUPR1, IRF7, ALOX5, SELE, CD14 STAT5A, IL18, TBX21, TLR2, TNFSF14, PTPN22, TNFSF13, TLR4, TNFSF12, TLR6, SKAP1, HLA-DMA, C1QC, TLR7, TLR8, B2M, NOD2, SH2D1A, IFNG, IL1B, VNN1, LAG3, SPN, EBI3, SYK, ICAM1, CRTAM, positive regulation of immune IL29, CD3E, SLA2, SERPING1, NFAM1, CD40, TRAT1, PDCD1LG2, NCR3, C1QA, CD38, C1QB, LAT2, 3 GO:0002684 87 771 238 13528 6.41389 1.15E-45 SIRPG, CD86, CD37, CD80, TNFSF13B, LAX1, LCK, TNFSF12-TNFSF13, VSIG4, CD226, HLA-DRA, system process C3AR1, FCER2, CD247, KLRK1, IL7R, TNFRSF4, CD74, VCAM1, IRAK3, TAP2, ZAP70, CD2, FCER1G, IL2RG, CD4, C2, CD5, CD27, CD28, PTPRC, CR1, GIMAP5, IL2RA, CR2, CARD9, IKZF1, IL7, THEMIS, TNFRSF13C, IDO1, GIMAP1, CORO1A, P2RX7, CD19, PLCG2, CD79A, CLEC7A, SASH3 ZBTB32, CD8A, CD8B, STAT5A, TLR1, IL21R, TLR2, TNFSF14, PTPN22, TLR4, TLR6, HLA-DMA, TLR7, IL10, FLT3LG, CD48, NLRC3, CXCR5, MS4A1, FAS, SPN, RHOH, SYK, GAPT, ICAM1, CRTAM, CD3G, CD3D, CD3E, SLA2, RELB, NFAM1, CD40, WAS, LAT2, CD86, UNC13D, CD80, CD40LG, LAX1, LCK, 4 GO:0045321 leukocyte activation 85 771 242 13528 6.16287 5.46E-43 TSHR, KIR3DL1, LCP2, CSF2, GPR183, ITGAL, CSF1, KLRK1, IL7R, TNFRSF4, ITGAM, CD74, HSH2D, VCAM1, DOCK2, ZAP70, CD2, BCL3, CD4, BLNK, CD7, CD28, PTPRC, GIMAP5, IKZF1, IL7, FLT3, THEMIS, MYO1F, KIR2DS4, ITGA4, SLAMF7, FOXP3, SLAMF1, VAV1, GIMAP1, LAT, P2RX7, PLCG2, IRF1, CD79A, CLEC7A, IRF4, BANK1 ZBTB32, CD8A, CD8B, STAT5A, TLR1, IL21R, TLR2, TNFSF14, PTPN22, TLR4, TLR6, HLA-DMA, TLR7, IL10, FLT3LG, CD48, NLRC3, CXCR5, MS4A1, FAS, LTB, LTA, SPN, RHOH, SYK, GAPT, ICAM1, CRTAM, CD3G, CD3D, CD3E, SLA2, RELB, NFAM1, CD40, WAS, LAT2, CD86, UNC13D, CD80, CD40LG, LAX1, 5 GO:0001775 cell activation 92 771 287 13528 5.62452 6.63E-43 LCK, TSHR, KIR3DL1, LCP2, CSF2, GPR183, ITGAL, TNF, CSF1, KLRK1, IL7R, TNFRSF4, ITGAM, CD74, HSH2D, VCAM1, DOCK2, ZAP70, CD2, BCL3, GP1BA, CD4, BLNK, CD7, CD28, PTPRC, GIMAP5, IKZF1, PLEK, IL7, FLT3, THEMIS, MYO1F, KIR2DS4, ITGA4, SLAMF7, FOXP3, SLAMF1, VAV1, GIMAP1, P2RY12, LAT, P2RX7, P2RX1, PLCG2, IRF1, CD79A, CLEC7A, IRF4, BANK1 ZBTB32, CD8A, CD8B, STAT5A, IL21R, TNFSF14, PTPN22, HLA-DMA, IL10, FLT3LG, CD48, NLRC3, CXCR5, MS4A1, FAS, SPN, RHOH, SYK, GAPT, ICAM1, CRTAM, CD3G, CD3D, CD3E, SLA2, RELB, NFAM1, CD40, WAS, LAT2, CD86, UNC13D, CD80, CD40LG, LAX1, LCK, TSHR, KIR3DL1, GPR183, 6 GO:0046649 lymphocyte activation 75 771 199 13528 6.61283 3.63E-40 ITGAL, KLRK1, IL7R, TNFRSF4, ITGAM, CD74, HSH2D, VCAM1, DOCK2, ZAP70, CD2, BCL3, CD4, CD7, CD28, BLNK, PTPRC, GIMAP5, IKZF1, IL7, FLT3, THEMIS, KIR2DS4, ITGA4, SLAMF7, FOXP3, SLAMF1, VAV1, GIMAP1, P2RX7, PLCG2, IRF1, CD79A, CLEC7A, IRF4, BANK1 STAT5A, TBX21, IL18, TNFSF14, TLR4, TNFSF13, TNFSF12, HLA-DMA, IL10, IFNG, VNN1, IL1B, FAS, SPN, EBI3, LAG3, SYK, SIT1, CD3E, IL27, SLA2, TNFRSF14, NFAM1, CD40, PDCD1LG2, CD38, BPI, SIRPG, CD86, UNC13D, CD80, TNFSF13B, LAX1, PRAM1, LCK, TNFSF12-TNFSF13, VSIG4, CD226, 7 GO:0050865 regulation of cell activation 69 771 175 13528 6.91815 2.68E-38 LST1, KLRK1, IL7R, TNFRSF4, CD74, VCAM1, ZAP70, CD2, IL2RG, CD4, HLA-DOA, CD5, CD27, CD28, PTPRC, GIMAP5, IL2RA, PLEK, IKZF1, IL7, FLT3, TNFRSF13B, TNFRSF13C, CTLA4, IDO1, FOXP3, GIMAP1, TIGIT, LAT, CORO1A, CD274, IRF4, SASH3 STAT5A, TBX21, IL18, TNFSF14, TNFSF13, TNFSF12, HLA-DMA, IL10, IFNG, VNN1, IL1B, FAS, SPN, EBI3, LAG3, SYK, SIT1, CD3E, IL27, SLA2, TNFRSF14, NFAM1, CD40, PDCD1LG2, CD38, BPI, SIRPG, regulation of leukocyte CD86, UNC13D, CD80, TNFSF13B, LAX1, PRAM1, LCK, TNFSF12-TNFSF13, VSIG4, CD226, LST1, 8 GO:0002694 67 771 166 13528 7.08184 6.78E-38 KLRK1, IL7R, TNFRSF4, CD74, VCAM1, ZAP70, CD2, IL2RG, CD4, HLA-DOA, CD5, CD27, CD28, PTPRC, activation GIMAP5, IL2RA, IKZF1, IL7, FLT3, TNFRSF13B, TNFRSF13C, CTLA4, IDO1, FOXP3, GIMAP1, TIGIT, LAT, CORO1A, CD274, IRF4, SASH3 STAT5A, TBX21, IL18, TNFSF14, TNFSF13, TNFSF12, HLA-DMA, IL10, IFNG, VNN1, IL1B, FAS, SPN, regulation of lymphocyte EBI3, LAG3, SYK, SIT1, CD3E, IL27, SLA2, TNFRSF14, CD40, NFAM1, PDCD1LG2, CD38, SIRPG, CD86, 9 GO:0051249 63 771 148 13528 7.46892 3.51E-37 CD80, TNFSF13B, LAX1, LCK, TNFSF12-TNFSF13, VSIG4, LST1, KLRK1, IL7R, TNFRSF4, CD74, VCAM1, activation ZAP70, CD2, IL2RG, CD4, HLA-DOA, CD5, CD27, CD28, PTPRC, GIMAP5, IL2RA, IKZF1, IL7, FLT3, TNFRSF13B, TNFRSF13C, CTLA4, IDO1, FOXP3, GIMAP1, TIGIT, LAT, CORO1A, CD274, IRF4, SASH3 AIF1, LY86, TLR1, TLR2, TLR4, TLR5, CXCL11, TLR6, C1QC, TLR7, TLR8, IL10, CXCL10, TLR9, CD44, CCL3L1, AOAH, CCL3L3, TICAM2, VNN1, IL1B, SERPINA1, XCR1, CIITA, IL18RAP, LY96, IL27, LYZ, SERPING1, CCL4L2, NFAM1, CD40, NLRP3, NCR3, C1QA, C1QB, SIGLEC1, CCR7, UNC13D, CCR5, 10 GO:0006954 inflammatory response 91 771 325 13528 4.91289 4.26E-37 CCR4, CD40LG, CCR2, PLA2G7, VSIG4, PLA2G2D, PTAFR, C3AR1, ITGAL, CCL3, TNF, CYSLTR1, CCR1, CXCL9, ITGB2, FPR2, GPR68, CCL5, TNFRSF4, CCL4, CCL24, CCL22, TNFRSF1B, CCL23, C2, BLNK, TLR10, CR1, IL2RA, CR2, IL23R, LIPA, CCL19, IDO1, CCL18, CD180, CCL17, APOL2, ORM1, APOL3, CCL13, CYBB, P2RX7, P2RX1, NUPR1, CXCL13, IRF7, CLEC7A, ALOX5, PLA2G4C, SELE, CD14 IL18, STAT5A, TNFSF14, HLA-DMA, IL10, IFNG, IL1B, VNN1, SPN, LAG3, EBI3, SYK, SIT1, CD3E, IL27, TNFRSF14, PDCD1LG2, CD86, SIRPG, TNFSF13B, CD80, LAX1, LCK, VSIG4, KLRK1, IL7R, CD74, 11 GO:0050863 regulation of T cell activation 51 771 117 13528 7.64828 2.00E-30 VCAM1, CD2, ZAP70, IL2RG, CD4, HLA-DOA, CD5, CD28, PTPRC, GIMAP5, IL2RA, IKZF1, IL7, CTLA4, TNFRSF13C, IDO1, FOXP3, GIMAP1, TIGIT, LAT, CORO1A, CD274, IRF4, SASH3 STAT5A, TLR2, PTPN22, TLR4, TLR6, TLR7, HLA-DMA, C1QC, SKAP1, TLR8, B2M, SH2D1A, NOD2, IL1B, positive regulation of immune LAG3, SYK, CRTAM, IL29, CD3E, SLA2, SERPING1, NFAM1, NCR3, C1QA, C1QB, LAT2, TNFSF13B, 12 GO:0050778 55 771 145 13528 6.65540 3.18E-29 LAX1, VSIG4, CD226, HLA-DRA, C3AR1, FCER2, CD247, KLRK1, IRAK3, TAP2, ZAP70, FCER1G, C2, response PTPRC, CR1,
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