Online Submissions: http://www.wjgnet.com/esps/ World J Gastroenterol 2014 January 14; 20(2): 498-508
[email protected] ISSN 1007-9327 (print) ISSN 2219-2840 (online) doi:10.3748/wjg.v20.i2.498 © 2014 Baishideng Publishing Group Co., Limited. All rights reserved. ORIGINAL ARTICLE Deletion of Gpr128 results in weight loss and increased intestinal contraction frequency Ying-Yin Ni, Yan Chen, Shun-Yuan Lu, Bi-Ying Sun, Fang Wang, Xiao-Lin Wu, Su-Ying Dang, Guo-Hua Zhang, Hong-Xin Zhang, Yin Kuang, Jian Fei, Ming-Min Gu, Wei-Fang Rong, Zhu-Gang Wang Ying-Yin Ni, Yan Chen, Fang Wang, Xiao-Lin Wu, Su-Ying mixed 129/BL6 background was generated. The mice Dang, Ming-Min Gu, Zhu-Gang Wang, Department of Medical were genotyped by polymerase chain reaction (PCR) Genetics, E-Institutes of Shanghai Universities, Shanghai Jiao analysis of tail DNA and fed a standard laboratory chow Tong University School of Medicine, Shanghai 200025, China diet. Animals of both sexes were used, and the phe- Shun-Yuan Lu, Hong-Xin Zhang, Zhu-Gang Wang, Research notypes were assessed by histological, biochemical, Centre for Experimental Medicine, Rui Jin Hospital Affiliated molecular and physiological analyses. Semi-quantitative with Shanghai Jiao Tong University School of Medicine, Shang- reverse transcription-PCR and Northern blotting were hai 200025, China Bi-Ying Sun, Guo-Hua Zhang, Wei-Fang Rong, Department used to determine the tissue distribution of Gpr128 of Physiology, Shanghai Jiao Tong University School of Medi- mRNA. Beginning at the age of 4 wk, body weights cine, Shanghai 200025, China were recorded every 4 wk.