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Bonnie Bassler LEHMAN AND ALLIS TO RECEIVE 2008 ASBMB AWARDS November 2007 Capecchi Awarded Nobel Prize in Medicine American Society for Biochemistrye mistry and Molecular Biology Scientists helping scientists… It costs no more to choose the very best for your custom peptides and antibodies… Ac-C T P R Q I pS F N F K-OH All peptides are made in our laboratories 1461.640 with the most rigorous QC in the industry – pSFNFK-H3PO4 -98 623.245 We sequence every purified -H PO peptide we manufacture! 3 4 PhD scientists with over 70 years of 623.0 626.5 combined experience in Chemistry, Mass 293.141 72 Cell Biology and Immunology 1218.599 1169.510 1347.658 536.784 740.405 809.426 1317.591 6 246.072 499.227 972.531 400 600 800 1000 1200 1400 Mass Complete antibody protocols and no hidden charges. Phosphospecific antibody experts! Custom peptides up to 100 AAs in length and at purities up to >98%. Peptides for epitope mapping as low as $4/AA. Modifications include phosphorylated amino acids, dye-labeling, cyclic peptides, and peptides with stable isotopes. Experience for yourself why research scientists around the world trust 21st Century Biochemicals for their custom peptides and antibodies! Come speak with our scientists at: Biomedical Research Equipment and Supplies Exhibit at Harvard Medical School Sept. 19 – 20 Society for Neuroscience, San Diego, CA Nov. 3 – 7 American Society for Cell Biology, Washington, DC Dec. 1 – 5 www.21stcenturybio.com 260 Cedar Hill Street, Marlboro, MA 01752 Made in the P: 508.303.8222 Toll-free: 877.217.8238 F: 508.303.8333 E: [email protected] U.S.A. contents NOVEMBER 2007 ON THE COVER: ASBMB Member Mario R. Capecchi society news has been awarded the 2008 Nobel Prize in Physiology or 2 President’s Message Medicine for his pioneering work in gene targeting in mice. 3 Washington Update 8 8 Mario R. Capecchi Receives Nobel Prize in Physiology or Medicine special interest NIH Spending on Training Grants and Fellowships 10 Trends in Postdoctoral Training 900,000 5.00 800,000 4.50 700,000 4.00 3.50 2008 meeting overview 600,000 3.00 500,000 2.50 DOLLARS 400,000 2.00 14 The 2008 Herbert Tabor/ 300,000 1.50 Journal of Biological Chemistry 200,000 1.00 Lectureship: I. Robert Lehman 100,000 0.50 0 0.00 1983 1985 1987 1989 1991 1993 1995 1997 1999 2001 2003 2005 2007 15 The 2008 ASBMB Merck YEAR Award: C. David Allis Dollars Percent of total NIH Budget science focus 10 28 Bonnie Bassler: Understanding How Bacteria Communicate departments 4 News from the Hill 6 Member Spotlight 16 Minority Affairs 20 Career Insights 22 Education and Training 24 Industry Perspective 26 BioBits resources at the 2006 SSCACNAS SC Conference. 31 For Your Lab 16 32 Career Opportunities 36 Scientific Meeting Calendar 26 November 2007 ASBMB Today 1 firstsecondpresident’s words message A monthly publication of The American Society for Biochemistry and Molecular Biology Great Session Officers Heidi E. Hamm President Planned for Grad Gregory A. Petsko President-Elect Mark A. Lemmon Secretary Students and Merle S. Olson Treasurer Council Members Postdocs at Alan Hall Kuan-Teh Jeang Suzanne R. Pfeffer Linda J. Pike Annual Meeting John D. Scott Joan A. Steitz Kevin Struhl James A. Wells BY HEIDI HAMM Ex-Officio Members Ellis Bell Chair, Education and Professional Development Committee Laurie S. Kaguni hile public policy is obviously and discussion session on career Chair, Meeting Committee Wa major interest of mine (as options, featuring speakers from the George Hill those of you who read my columns areas of patent law, science writing, Chair, Minority Affairs Committee Kendall J. Blumer here know) I am also an educator industry consulting, and more. Anna Marie Pyle and a researcher. Thus, I’m happy to A group networking lunch will be Co-chairs, 2008 Program Committee write this month about another sub- followed by short oral talks presented Mary J. C. Hendrix Chair, Public Affairs Advisory Committee ject dear to my heart—graduate and by select Graduate Minority and Robert E. Rhoads postdoctoral professional develop- Graduate/Postdoctoral Travel Award Chair, Publications Committee ment and the exciting program the recipients. Herbert Tabor Editor, JBC Society has created for the annual Afternoon workshops will high- Ralph A. Bradshaw meeting in San Diego next April. light topics including: Lab Produc- A. L. Burlingame The Graduate and Postdoctoral tivity/Lab Management, Matching Co-editors, MCP Edward A. Dennis Professional Development Program Yourself with a Mentor, Pinpointing Editor, JLR has been put together by: the Perfect Postdoc, and Making the Most of Your Postdoc Experience. ASBMB Today t,JNCFSMZ%PEHF,BėB 6OJWFSTJUZ Editorial Advisory Board PG $POOFDUJDVU )FBMUI $FOUFS JO Following these career development Alex Toker 'BSNJOHUPO workshops, program attendees will Chair join the main meeting at The Herbert Mike Autry Greg P. Bertenshaw t+PIO . %FOV 6OJWFSTJUZ PG Craig E. Cameron A. Stephen Dahms 8JTDPOTJO .FEJDBM 4DIPPM Tabor/Journal of Biological Chemistry Irwin Fridovich Richard W. Hanson Lectureship, featuring I. Robert Leh- Elizabeth A. Komives t "OO - .JMMFS 6OJWFSTJUZ PG man of Stanford University. Bettie Sue Masters Luke A. O’Neill 8JTDPOTJOo.BEJTPO Duanqing Pei Carol C. Shoulders Space is limited, and registration is Robert D. Wells t+FSPNF $ /XBDIVLXV 4BDLMFS accepted when registering for Experi- *OTUJUVUF PG (SBEVBUF #JPNFEJDBM ASBMB Today mental Biology (EB) 2008. The cost is 4UVEJFT /FX :PSL 6OJWFSTJUZ Nicole Kresge Editor $20 for ASBMB members and $25 for [email protected] 4DIPPM PG .FEJDJOF BOE all other EB registrants. Nancy J. Rodnan Director of Publications t.JUJ4IBI "SJ[POB 4UBUF [email protected] Please note that if you are a 6OJWFSTJUZ Barbara Gordon Executive Director Graduate Minority or Graduate/Post- [email protected] “We wanted to reach out to doctoral Travel Award recipient, reg- Magazine design & production: Amy Phifer younger members,” says Dodge- istration for the program is included For information on advertising contact Kafka, “to provide them some advice as part of your travel award. FASEB AdNet at 800-433-2732 ext. 7157 or 301-634-7157, or E-mail [email protected]. on training and career options and We hope all postdocs and gradu- to make them feel more included in ate students will plan to attend. And Society affairs.” please, all you “seasoned” investiga- The day-long event kicks off on tors, make sure to encourage your www.asbmb.org Saturday, April 5, 2008, with a panel students to attend. November 2007 washington update FA S E B FASEB Comments on Biosecurity Oversight Proposal BY CARRIE D. WOLINETZ arlier this year, the National Science Advisory Board IBCs, and Institutional Review Boards (IRBs), the difficulty Eon Biosecurity (NSABB), the federal advisory group in identifying what is to be overseen is unique. One is tasked with developing guidelines for dual use biologi- either using animals, recombinant DNA, or human sub- cal research (i.e. research that can be used for positive jects and is therefore subject to review, or one is not. This benefit or misused to cause harm), released a draft report is in contrast to dual use research, in which the need for on a proposed oversight framework for dual use research. review is subject to a great deal of interpretation. NSABB The document details guidance for the identification, itself found that there were “significant differences in review, and communication of what NSABB terms dual assessments made by individual NSABB members” and use research of concern, or DURC. The major points of that there were “difficulties inherent in explicitly defining the proposal include: the point at which the magnitude and/or immediacy of the s2ECOMMENDATIONSFORMANDATORYTRAININGFORALLSCIENTISTS threat of misuse makes dual use research ‘of concern.’” TRAINEES ANDSTAFFABOUTDUALUSERESEARCH Because of the difficulties in identifying research to be s!LLPRINCIPALINVESTIGATORSWOULDREVIEWTHEIRRESEARCH reviewed, FASEB also expressed concerns related to the PROGRAMTOSEEIFITMATCHESTHECRITERIAFOR$52#BASED ONAQUESTIONNAIREDEVELOPEDBY.3!""IFNOT THEYWOULD feasibility and potential burden of the system. In particular, CHECKABOXONGRANTAPPLICATIONSTOTHATEFFECTANDAGREE the vagueness of the criteria could lead to vast under- TOYEARLYREVIEW reporting by investigators or overreporting by institutions s2ESEARCHIDENTIlEDAS$52#WOULDTRIGGERANINSTITUTIONAL concerned about liability. Either scenario diminishes the RISKASSESSMENT BASEDREVIEW PERHAPSTHROUGHTHEEXISTING goal of increasing security. Also of security concern are )NSTITUTIONAL"IOSAFETY#OMMITTEES)"#S ANDDEVELOPMENT OFSUBSEQUENTRISKMANAGEMENTANDCOMMUNICATIONSPLANS the products that could potentially be produced during the .3!""ALSOPROVIDESTOOLSANDGUIDANCEFORDEVELOPMENT review process. The scientific and security communities OFSUCHPLANS have struggled, in a number of venues, with the concept s2ECOMMENDATIONFORMANDATORYCOMPLIANCEWITHDUALUSE of “sensitive but unclassified” information. The proceed- OVERSIGHTGUIDANCEANDPENALTIESFORNON COMPLIANCE ings of dual use review meetings, the documents provided s2ECOMMENDATIONSTHATSCIENTIlCSOCIETIESDEVELOPCODES by NSABB as tools for review, or the documenting of deci- OFCONDUCTFORDUALUSERESEARCHANDPROVIDEGUIDANCEAND sions that identify research that may merit discontinuation SAMPLELANGUAGEFORCODES or restrictions on publication: whose responsibility is it to s!LATITUDEFORINTERPRETATIONDELIBERATELY SOTHATFEDERAL AGENCIESCANMAKETHEIROWNDETAILEDREGULATIONS ensure their security? Many questions are raised by a pro- Although
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