CELEBRATE PRINCETON INVENTION 2016 It takes a university…

Office of the Dean for Research f necessity is the mother of invention, then the university may be the www.princeton.edu/research extended family that nurtures a discovery from its birth in a scientist’s 91 Prospect Ave. lab through its trying experimental phases on the path to becoming Princeton, NJ 08540 I a benefit to society. We often talk about this last stage, but it is an Tel.: 609-258-5500 [email protected] invention’s infancy and early development that usually require the most creativity and effort. To learn more about the researchers and Those early days involve long technologies in this brochure, contact: hours at the lab bench, sleepless John Ritter nights, false starts and do-overs, Director, Technology Licensing and yet Princeton inventors choose www.princeton.edu/patents this path because they glimpse the 87 Prospect Ave., 3rd Floor greater potential of their work. Princeton, NJ 08544 They know — or at least they Tel.: 609-258-1001 hope — that the knowledge they [email protected] create or discover could treat a viral illness for which we have no cure, For information on fostering industry- faculty collaborations, contact: or help restore movement after a stroke, or guard pacemakers against Coleen Burrus malicious hackers. These faculty Director, Corporate Engagement and members, postdoctoral researchers, Foundation Relations cefr.princeton.edu and graduate and undergraduate 91 Prospect Ave. students are inspired not only by Princeton, NJ 08540 the drive to uncover knowledge but Tel.: 609-258-3277 also by the desire to contribute in [email protected] meaningful ways to societal and environmental well-being. Each of these inventors knows that inspiration is not enough. For inquiries regarding Invention stems not just from brilliant ideas and hard work but also sponsored research, contact: from luck and serendipity, and the ability to recognize an important Jeff Friedland finding among data from an experiment that didn’t have the expected Director, Research and Project result. At Princeton we are fortunate to be able to provide an Administration environment where all research can thrive, and individuals are afforded www.princeton.edu/orpa 87 Prospect Ave., 2nd Floor the opportunity to dream the innovations of the future. We hope you Princeton, NJ 08544 will join us as we celebrate the extended family of University researchers Tel.: 609-258-3090 who bring discoveries to life. [email protected] Pablo Debenedetti Dean for Research For more on entrepreneurship at Princeton, contact: Class of 1950 Professor in Engineering and Applied Science Professor of Chemical and Biological Engineering Mung Chiang Inaugural Chair, Princeton Entrepreneurship Council Director, Keller Center entrepreneurs.princeton.edu kellercenter.princeton.edu Princeton Entrepreneurial Hub 34 Chambers St. Princeton, NJ 08542 Tel.: 609-258-5071 [email protected] Table of Contents

Featured Inventions 2016 8 Student-powered venture 12 Bridging the gap Undergraduate startup brings University discoveries receive 3 A test for mitochondrial health electricity to remote areas additional development to make them ready for use Ileana Cristea, Professor of Molecular 9 Princeton Plasma Physics Biology Laboratory spins off new 13 New ideas in the natural 3 Adaptive cognitive prosthetic technologies sciences Timothy Buschman, Assistant Professor Inventions range from food Early-stage research projects of Psychology and the Princeton sterilization to bomb detection provide the seeds of innovation Neuroscience Institute 10 Startup culture 14 Transformative technologies 4 Securing implantable medical Companies based on Princeton Major impacts emerge from cross- devices against attack innovations spark economic disciplinary teams and diverse Niraj Jha, Professor of Electrical activity perspectives Engineering 11 Collaborations with industry 5 Selective fluorination of drug Corporate engagement plays and PET imaging molecules an essential role in developing John Groves, Hugh Stott Taylor Chair of University inventions into real- Chemistry world technologies 6 A fast and easy method for making Janus nanoparticles Rodney Priestley, Associate Professor of Chemical and Biological Engineering Inventors F Y16 7 Small, fast and cost-efficient flow sensors 15 Princeton faculty members and teams Marcus Hultmark, Assistant Professor of A list of Princeton inventions by current and former members Mechanical and Aerospace Engineering of the University research community for fiscal year 2016

The Andlinger Center for Energy and the Environment

invention.princeton.edu Celebrate Princeton Invention 2016 1 Addressing society’s most pressing challenges

esearch conducted in the laboratories at Princeton is aimed at answering fundamental questions about life, the world around us and the universe beyond. RSometimes this quest for understanding leads to technologies that can address society’s most pressing challenges, such as helping patients recover from stroke or improving the detection of cancer. When this synergy of basic and applied research occurs, Princeton’s Office of Technology Licensing assists our faculty researchers and their teams with the transfer of innovations to partners with the skills to further develop them to the point where they can benefit our planet and society. Our office continues to evolve as we respond to increased interest from our University community to engage in technology transfer for the benefit of society. Over the past year we have ramped up our capability to advise faculty and students about startup ventures through the creation of a New Ventures position. Through such activities, universities can stimulate economic growth in ways that provide new jobs, livelihoods and sometimes the foundation of an entire industry. Each year, Celebrate Princeton Invention gives us the opportunity to honor the Princeton faculty, staff researchers and students who create new and transformative technologies. Their efforts constitute one of the many ways in which Princeton fulfills its mission of service to the nation and to humanity. John Ritter Director, Technology Licensing

Rapid changes to technology and Fundamental, curiosity-driven scientific society are making the connections inquiry is at the heart of Princeton’s research between world-class research and the endeavors. This exploration of nature and “innovation ecosystem more important “our place within it inspires and educates the than ever. At Princeton, we are eager to next generation of science and engineering see those connections flourish, and our leaders and lays the groundwork for future students and faculty are enthusiastically innovations. The quest for knowledge also collaborating with both industry and sometimes results in the discovery of new the nonprofit sector to discover and technologies that, with further development, implement ideas that will help address can benefit humanity. Through Celebrate the world’s challenges. Princeton Invention, we are proud to celebrate Christopher L. Eisgruber the bold and groundbreaking work of our President, Princeton University faculty, postdoctoral researchers and students. David S. Lee Provost, Princeton University 2 Celebrate Princeton Invention 2016 ” invention.princeton.edu” Featured Inventions 2016

Invention Collaborators A test for mitochondrial health Rommel Mathias, a former postdoctoral research fellow in molecular biology; Todd Greco, associate research scholar Ileana Cristea, professor of molecular biology in molecular biology; Thomas Shenk, the James A. Elkins Jr. Professor in the Life Sciences; and Adam Oberstein, a What it does postdoctoral research fellow in molecular biology. he role of mitochondria — which are known as the power Tplants of the cell — in human health is an active area of Development status research. A team led by Ileana Cristea is pioneering methods to Patent protection is pending. Princeton is seeking outside monitor and explore molecular regulators that have implications interest for further development of this technology. for the research and treatment of mitochondrial diseases as well Funding source as cancer, aging and viral infections. National Institutes of Health Cristea’s research group has identified new enzymatic activity by an important regulator of cellular energy production known as sirtuin 4. The researchers demonstrated that Invention sirtuin 4 acts in mitochondria to turn off energy production by inhibiting an important piece of the energy-making machinery, Adaptive cognitive prosthetic the pyruvate dehydrogenase complex. Sirtuin 4 inhibits Timothy Buschman, assistant professor of pyruvate dehydrogenase activity through a process known as psychology and the Princeton Neuroscience delipoylation. Institute The team created an assay to accurately measure delipoylation in cells or tissues, which can be used to monitor the activities of What it does sirtuin 4 and the pyruvate dehydrogenase complex. This assay he adaptive cognitive prosthetic is a device that, when can be performed T implanted in the brain, helps recover cognitive function in in any type of cell, patients with a stroke or traumatic brain injury. The goal is to tissue or patient restore or replace a sample. The test damaged brain region. can help researchers When a region of quickly assess the the brain ceases to activity of sirtuin 4 function, the adaptive and discover ways cognitive prosthetic to inhibit it to boost will enable signals in mitochondrial health, the brain to bypass or, alternatively, the damaged region to activate the enzyme restore functionality. to shut off harmful The device first records the activity mitochondrial activity. of hundreds of Cristea noted that neurons that normally stress, nutritional feed instructions deficiencies and to the damaged viral infections can Ileana Cristea region. The adaptive destabilize sirtuin 4 cognitive prosthetic functions and trigger then uses these Timothy Buschman dysfunction in energy metabolism. An assay to detect sirtuin readings and a novel 4 could help researchers design therapeutic interventions that learning algorithm restore mitochondrial health. Pyruvate dehydrogenase complex to calculate instructions that can replace those that would have deficiencies have been linked to severe mitochondrial diseases traveled through the diseased region. The device delivers those that lead to intellectual disability, loss of balance and brain instructions to the appropriate region of the brain. malformation. Given the finding of the Cristea lab that sirtuin 4 Such a device could help victims of stroke, trauma or other regulates the activity of the pyruvate dehydrogenase complex, brain injury. Stroke often involves the destruction of cells that these assays can provide a means for understanding the causes are needed to transmit signals from one part of the brain to of these diseases. Because mitochondria are found in every cell another. For example, the parietal cortex passes visual signals to and are fundamental to growth, the test also may aid in studies of various areas of the brain that allow us to interpret what we see. cancer, aging, cell signaling and viral infection. Damage to the parietal cortex can cause blindness in one half invention.princeton.edu Celebrate Princeton Invention 2016 3 of the individual’s normal field of view. To restore sight, the To enhance adaptive cognitive prosthetic would identify the missing medical-device signals, compute substitute instructions and deliver them to security — without other, intact regions. requiring the devices Contributors to be upgraded — Jha and his colleagues Sina Tafazoli, postdoctoral research associate in the Princeton developed a Neuroscience Institute; Cynthia Steinhardt, Class of 2016; and technology Katherine Letai, Class of 2017. called MedMon Development status that monitors Patent protection is pending. Princeton is seeking outside communications interest for further development of this technology. and, if it detects Funding source unusual activity, National Institutes of Health interrupts the transfer of information. MedMon is being miniaturized so that it Niraj Jha can be worn on a belt Invention or carried in a pocket. Securing implantable medical More recently, Jha and colleagues at Purdue University devices against attack developed a secure technology called SecureVibe that can be incorporated into new medical devices. The new technology Niraj Jha, professor of electrical engineering consists of the addition of a secure channel of communication that allows encrypted messages to be periodically sent between What it does the device and an external station with high energy efficiency. n an increasingly connected world, a new technology Ideveloped by Niraj Jha and his colleagues can provide Collaborators security for pacemakers, insulin pumps and other medical MedMon: Meng Zhang, who earned his Ph.D. in electrical devices that are at risk of being hacked. engineering in 2013 and is now a member of the technical staff Implantable and wearable medical devices that at WorldQuant, and Anand Raghunathan, professor of electrical communicate over wireless networks are vulnerable to attacks and computer engineering at Purdue University. that can either block communications altogether, or send SecureVibe: Younghyun Kim, Woo Suk Lee, Vijay Raghunathan instructions to the device to cause harm, such as providing and Anand Raghunathan, all at Purdue University. an overdose of insulin or triggering an arrhythmia. Another Development status risk is from hackers who eavesdrop on the communications Patent protection is pending. Princeton is seeking outside to obtain private medical information. Encryption, the interest for further development of this technology. typical security solution, uses significant amounts of power, which keeps it from being added to these devices. Funding source National Science Foundation

4 Celebrate Princeton Invention 2016 invention.princeton.edu Invention that adds fluorine to sites on molecules that previously were inaccessible by other techniques. The catalyst adds fluorine in Selective fluorination of drug and place of hydrogen in benzylic carbon-hydrogen bonds. PET imaging molecules The new technique can be used to produce radioactive 18 John Groves, the Hugh Stott Taylor Chair F isotopes for use as tracer molecules — which emit particles called positrons — that are detectable using PET scanning and of Chemistry can pinpoint the locations of cancer in the body. The method What it does could also be used to add 18F to various molecules and then test he invention is a method of adding fluorine to molecules for to see if certain attributes — such as specificity for cancer or T use in imaging and therapeutics. Fluorinated molecules are half-life — are improved. used as tracers that can detect cancer during positron emission Contributors tomography (PET) scans. Fluorine also can be added to drugs Wei Liu, who earned his Ph.D. in chemistry in 2014 and is now where the replacement of select hydrogen atoms with fluorine a research associate at the University of California-Berkeley, atoms can improve a drug’s potency and potentially reduce side and Xiongyi Huang, who earned his Ph.D. in chemistry in 2016 effects. Until now, however, fluorination involved using toxic and is now a research associate at the California Institute of and complicated fluorinating agents and a multistep process. Technology. Groves and his collaborators invented new catalysts that Development status fluorinate molecules using safe-to-handle fluoride salts in a single step. The technique is clean, fast and inexpensive, and Patent protection is pending. Princeton is seeking outside can be used to generate imaging molecules, drug candidates interest for further development of this technology. and new agricultural chemicals. Funding sources The method involves the use of a manganese-based catalyst U.S. Department of Energy and the National Science Foundation

John Groves (back row, far right), with his laboratory team invention.princeton.edu Celebrate Princeton Invention 2016 5 Invention A fast and easy method for making Janus nanoparticles Rodney Priestley, associate professor of chemical and biological engineering What it does ike the two-faced Roman god for which they are named, L Janus particles have on their surfaces two physically distinct regions with different functions. For example, Janus particles may be hydrophobic on one side and hydrophilic on the other. Such characteristics can enable new capabilities in drug delivery, medical imaging, electronic displays and sensors, and as surfactants in personal-care products. Priestley and collaborator Robert Prud’homme, professor of chemical and biological engineering, have developed a method for the rapid and easy manufacture of nanoscale polymer Janus particles. The method harnesses a technique developed by Prud’homme and colleagues called Flash NanoPrecipitation. The system involves rapidly mixing two polymers, one for each of the two regions of the Janus particle, plus a solvent in a chamber. The choice of solvent and polymers, combined with rapid mixing in the chamber, enables the polymers to aggregate into particles ranging from tens to hundreds of nanometers in length. The ability to easily and rapidly produce the particles could enable the more widespread use of Janus particles as amphiphiles, which are chemicals that have both water- and oil-soluble properties that make them ideal for use in personal and health care products. Current methods of producing these particles are cumbersome, requiring multistep procedures and lengthy Rodney Priestley process times. The new technology has the potential to make Janus particles on an industrial scale. One potential use for large numbers of nanometer-scale Janus particles is in highly stable foams and emulsions. Such emulsions could be used to deliver active ingredients and to enhance therapeutics, or as emulsifiers for agricultural chemicals. Janus particles themselves also offer the possibility to serve as bifunctional active components in personal health care products. Priestley and his team are also investigating their use as nano- erasers in cleaning applications. Collaborators Robert Prud’homme, professor of chemical and biological engineering; Chris Sosa and Vicki Lee, graduate students in chemical and biological engineering; Rui Liu, a former postdoctoral researcher at Princeton and professor at the School of Materials Science and Engineering, Tongji University, Shanghai. Development status Patent protection is pending. Princeton is seeking outside interest for further development of this technology. Funding source National Science Foundation

6 Celebrate Princeton Invention 2016 invention.princeton.edu Marcus Hultmark (front row, second from left), with his laboratory team

Invention to velocity can be decreased by using a wire that is only a fraction of a micrometer in width. This means it loses heat Small, fast and cost-efficient through conduction rather than convection via moving air. flow sensors Since thermal conductivity can be directly related to humidity, the sensing element gives an accurate measurement of humidity. Marcus Hultmark, assistant professor of Because it is insensitive to convection, the humidity sensor is mechanical and aerospace engineering reliable even under conditions of moving air or fluid flow. If What it does instead the sensor is designed to favor convection, it can be he research team led by Marcus Hultmark has invented a suite used to measure velocity. T of nanoscale flow sensors to measure humidity, temperature In addition to velocity and humidity, these sensors can be and velocity. The sensors’ small size and scalable manufacturing operated cold and be used to measure temperature at rates could make them valuable for a variety of applications, such much faster than conventional sensors. Together they form a as improving comfort levels in “smart homes,” sensing flow suite of sensors with unparalleled speed and resolution. parameters in automobile engines to improve performance, or Collaborators distributed monitoring of atmospheric conditions. Yuyang Fan, Matthew Fu and Clayton Byers, graduate students The sensors each consist of a micro-electromechanical in mechanical and aerospace engineering; and Gilad Arwatz, system (MEMS) device that can be produced using standard who earned his Ph.D. from Princeton in 2015 and is a former semiconductor manufacturing techniques. Compared postdoctoral researcher in Hultmark’s lab. to existing sensors, these are faster, smaller, simpler and Development status considerably cheaper. They consist of freestanding nanoscale InstruMems, a startup venture led by Arwatz, has formed to wire filaments strung across electrically conducting supports. develop the humidity sensor into a functional prototype. By incorporating effects of miniaturization both with respect to fluid mechanics and heat transfer, the design of the sensing Funding sources elements can be tailored to the quantity measured. The sensors Princeton University and the Fondation pour l’Etude des Eaux are operated in different modes depending on which property is du Léman measured. To measure humidity, the heated sensor’s sensitivity invention.princeton.edu Celebrate Princeton Invention 2016 7 Student-powered venture Undergraduate startup brings electricity to remote areas

t started as a class project to provide electricity to survivors “Our vision doesn’t stop at the local level,” Schwartz said. of the 2010 earthquakes in Haiti. Today, Princeton students “We imagine regional hubs of manufacturing and maintaining I Angelo Campus and Aaron Schwartz are taking the concept BoxPower using the regional labor force.” of “power in a box” to anyone who lives in remote areas poorly The BoxPower concept originated as a project called Power- served by the electrical grid. in-a-BoxTM led by faculty members at Princeton including Their product is BoxPower, a hybrid wind and solar-energy Catherine Peters, professor of civil and environmental system pre-assembled in a standard 20-foot shipping container. engineering, and Elie Bou-Zeid, associate professor of civil and The system can be transported anywhere in the world using environmental engineering, with support from the National the global shipping infrastructure and set up in less than a Science Foundation. Princeton students further developed the day without specialized tools or expertise. Once operational, concept in the course “Engineering Projects in Community BoxPower can provide renewable electricity to supply up to six Service” and, through a 2012 national competition called “P3: families at roughly one-third of the cost of operating a diesel- People, Prosperity and the Planet Student Design Competition powered generator. for Sustainability,” won a $90,000 grant from the U.S. “Because BoxPower requires no fuel purchases or significant Environmental Protection Agency. maintenance, it is an ideal solution for people who live in places BoxPower has since been the recipient of several startup where it is difficult to get regular supplies,” said Campus, Class competition awards including the 2016 U-Pitch New Jersey of 2016. “BoxPower is much better for the environment than a Collegiate Business Model Competition; the 2016 New Jersey diesel generator, and much less expensive.” Packed in each shipping container are solar panels, a wind Entrepreneurial Network Posters, Pitches and Prizes competition; turbine, a battery bank and a small backup generator in case of and the Princeton Social Innovation Competition. emergencies. When set up, the solar panels sit atop the box and Throughout the development of BoxPower, Schwartz and the wind turbine extends about 30 feet into the air using the Campus have received advice and support from Princeton’s shipping container for support. Keller Center. This spring, the students participated in the The team estimates that they can produce a BoxPower unit Keller Center’s eLab Incubator program, which provides for less than $40,000. They plan to conduct a pilot program in access to advisers, workshops and workspace at Princeton’s collaboration with the Navajo Tribal Utility Authority to provide Entrepreneurial Hub. “The eLab Incubator program gave us power to households living without access to electricity. With the opportunity to work with leading venture professionals an estimated 2 billion people worldwide living without reliable in a collaborative environment, and it is one of the really electrical power, the need for this system is considerable, said special opportunities that we have as students at Princeton,” Schwartz, Class of 2017. Campus said.

Princeton undergraduates Aaron Schwartz (left) and Angelo Campus are taking the concept of “power in a box” to remote areas poorly served by the electrical grid. The project has won several startup awards, including from the 2016 U-Pitch New Jersey competition (pictured).

8 Celebrate Princeton Invention 2016 invention.princeton.edu Princeton Plasma Physics Laboratory spins off new technologies Inventions range from food sterilization to bomb detection

ocated three miles from Princeton University’s main campus, the U.S. Department of Energy’s Princeton Plasma L Physics Laboratory (PPPL) is the nation’s premiere fusion- energy research center. It also is a wellspring of technological innovations that have the potential to benefit society. These technologies arise from the physics and engineering research that scientists at PPPL, which is managed by Princeton, conduct as part of the quest to develop fusion energy, a safe and environmentally attractive method of providing electricity using the same energy-generating process that occurs in the sun. Through PPPL’s technology-transfer office, promising discoveries can be transferred to private industry, academic institutions and other federal laboratories for development. “The technological discoveries that come from magnetic fusion research find applications in areas ranging from ones you might predict, such as aerospace and defense, to ones that might surprise you, such as improved food sterilization,” said Laurie Bagley, head of technology transfer, patents and publications at PPPL. Three of the technology spinoffs from PPPL are: MINDS Short for “Miniature Integrated Nuclear Detection System,” MINDS is a cost-effective, compact technology for scanning moving vehicles, luggage and other containers for signals associated with radiological weapons, also sometimes called dirty bombs. Developed by PPPL scientist Charles Gentile and Christopher Brunkhorst colleagues, MINDS could be deployed as a security measure at airports, tollbooths, shipping ports, festivals and in subways and overheating. Then, the eggs are bathed in hot water to ensure full other transportation systems to ensure public safety. pasteurization of the yolk and white. The technology detects several types of radioactive signals, Brunkhorst collaborated with David Geveke, lead scientist including X-rays, neutrons, and soft gamma and gamma at the USDA Agricultural Research Service in Wyndmoor, rays. The system recognizes distinctive energy signatures, Pennsylvania, and Andrew Bigley, an engineering technician or “fingerprints,” and compares them to the energy spectra recently retired from the USDA. associated with the radiological materials used in weapons. Advanced liquid centrifuge Gentile’s collaborators include Andrew Carpe, PPPL technical assistant; Steve Langish, PPPL technical supervisor; PPPL Today’s centrifuges are the workhorses of science, used to software engineers Kenny Silber and Bill Davis; Dana Mastrovito, purify and separate everything from DNA to weapons-grade a former PPPL software engineer who is now a doctoral student uranium. Centrifuges also are used in industry to remove toxic at Rutgers University; and Jason Perry, who earned his master’s compounds from industrial wastewater, extract oil from oil sands degree in computer science from Princeton in 2004. and even to clarify apple juice. PPPL scientists led by Hantao Ji, professor of astrophysical Egg pasteurization sciences at Princeton, have invented a new type of centrifuge that A novel method for rapidly pasteurizing eggs in the shell can segregate a mixture of fluids into separate parts based on could enhance the safety of the United States’ food supply. differences in density, while also combining two or more fluids to Current federal regulations do not require eggs sold in stores produce a uniform mixture or to enhance the rate of a chemical to be pasteurized, yet these eggs are often consumed raw or reaction. The advanced liquid centrifuge accomplishes these undercooked and cause more than 100,000 cases of salmonella tasks by having both an inner cylinder and an outer cylinder that illness each year in the United States. Pasteurization of shell eggs rotate independently of each other to create a sheared flow in could reduce the number of salmonella cases by up to 85 percent, the fluid. By injecting fluids at precise times and manipulating according to the U.S. Department of Agriculture (USDA). the rotation speed of both cylinders, the centrifuge can mix Researchers led by PPPL engineer Christopher Brunkhorst and then separate various ingredients without interruption in developed a method of using radio-frequency energy to transmit ways that are not available in today’s single-cylinder centrifuges. heat through the shell and pasteurize the yolk while the eggs Ji collaborated with PPPL scientists Adam Cohen, Philip rotate in a stream of cool water that protects them against Efthimion and Eric Edlund.

invention.princeton.edu Celebrate Princeton Invention 2016 9 Startup culture Companies based on Princeton innovations spark economic activity

esearch can make a difference in everyday lives, especially GPB Scientific when university discoveries can be translated into The letters in the name GPB Scientific stand for “Getting beneficial services through the entrepreneurial spirit of R People Better,” according to founder and CEO Michael Grisham. a startup company. A number of startups based on Princeton “We work to identify promising technologies and develop them innovations represent a vibrant hub of economic activity. into innovations that can improve human health.” Uniformity Labs One of these technologies originated in the Princeton laboratories of James Sturm, the Stephen R. Forrest Professor in 3-D printers have become a household name, but their Electrical Engineering, and Robert Austin, professor of physics. potential to transform industrial manufacturing has yet to In 2004, with electrical engineering graduate student Richard be realized. 3-D printing involves depositing a thin layer of Huang, the researchers published in Science a novel method for material — often a curable polymer or powder — on a surface separating biological molecules and living cells by running them and applying energy to cure or fuse the material only in through a sort of microfluidic maze consisting of a silicon chip selected locations, then repeating the process to build up a part layer by layer. small particle large particle To bring 3-D printing — also known as additive manufacturing — to the industrial scale, California-based Uniformity Labs is developing additive-manufacturing processes that are faster, more efficient and less expensive than today’s technologies. “There is a lot of room for growth in production-scale additive manufacturing of components in industries such as aerospace, automotive technology, and energy and power generation,” said Adam Hopkins, CEO of Uniformity Labs, who earned his doctorate in chemistry and bachelor of arts in physics from Princeton in 2012 and 2005, respectively. Uniformity Labs is working to develop discoveries made in the laboratory of posts streamlines Salvatore Torquato, professor of chemistry and the Princeton Institute for the Science and Technology of Materials, and dotted with pillars. As the cells migrated past the pillars, they Hopkins’ former adviser. took different paths depending on their size. “The overall effect is like a coin-sorter but for cells,” Grisham said. GPB Scientific is using the technology to isolate tumor cells from the blood to create a “liquid biopsy,” a non-invasive way to detect and diagnose cancer. These cells originate in solid tumors in the body’s organs and find their way into the blood. If unchecked, they can spread, or metastasize, to other organs. By isolating these tumor cells, which comprise just a tiny fraction of the total number of cells in the blood, GPB Scientific aims to provide clinicians with a way to diagnose cancer, determine the correct course of treatment, and monitor a patient’s progress. The research by Sturm and Austin enables GPB Scientific to separate tumor cells gently and uniformly with virtually no cell loss. The research was supported by the National Cancer Institute, the National Science Foundation, the State of New Jersey and the Defense Advanced Research Projects Agency. This transfer of University-led research into a clinical application would not be possible without the input of other Torquato, Hopkins and their Princeton colleagues invented experts in oncology and cell biology, Grisham said. To provide technologies for making starting materials that are less porous, such expertise, GPB Scientific collaborates with Curt Civin, and thus fuse more easily, than today’s materials. The research director of the Center for Stem Cell Biology and Regenerative on low-porosity materials, which was funded in part by the Medicine at the University of Maryland School of Medicine. National Science Foundation, could improve the quality of parts “The real breakthroughs in technologies that benefit patients made by printing in metal, ceramic, cement, plastic and glass, and society at large come from scientists who know how to among other materials. “We are developing technologies that are collaborate with researchers at other institutions and in industry,” required for additive manufacturing to achieve its full potential,” Grisham said. “That is really special. That is where true Hopkins said. innovation comes from.”

10 Celebrate Princeton Invention 2016 invention.princeton.edu FORGE Life Science Despite some recent successes, many viral diseases have no treatment, and most of the existing treatments target a specific virus rather than being able to treat a broad spectrum of viruses. Building on the discovery at Princeton of a family of human proteins that naturally defend against viral infection, a startup company called FORGE Life Science is working to develop broad-spectrum antiviral compounds. The company is building on research by professors Thomas Shenk and Ileana Cristea demonstrating that proteins known as sirtuins play a role in the body’s natural defenses, or intrinsic immunity, against viruses. With funding from the National Institutes of Health, Shenk, Princeton’s James A. Elkins Jr. Professor in the Life Sciences, and Cristea, professor of molecular biology, found that every member of the sirtuin family showed the ability to inhibit viral replication. Building upon that basic research, FORGE scientists are looking for small molecules that modulate the activity of sirtuin proteins to fight infection. They are initially targeting select sirtuins, such as 1, 2 and 6, in different combinations to improve the body’s ability to defend against viruses. Because sirtuins X-ray structure of sirtuin modulator SirReal2 (magenta) bound inhibit more than one type of virus, a sirtuin-based therapeutic to Sirtuin 2 enzyme illustrates the feasibility of developing drugs could target multiple viruses. targeting sirtuin enzymes to effect antiviral activity. “Our goal is to treat multiple viruses with one pill,” said Lillian Chiang, FORGE Life Science’s President and CEO. “This immune system is actively suppressed, such as in cases where could change how we practice medicine.” patients have received organ transplants. Because some FORGE Such broad-spectrum capabilities are common in drugs targeting sirtuins can cross the blood-brain barrier, the antibacterial medicines, but to date, the few antiviral treatments technology also has the potential to provide treatments for available are specific for certain viruses. With sirtuin-based viruses such as rabies and measles. “We can potentially address treatments, a doctor would not need to identify the virus, which diseases for which we have no cure,” Chiang said. is time-consuming and expensive. Instead, the doctor could Under Chiang’s leadership, FORGE Life Science is conducting prescribe a sirtuin-based drug based on the patient’s symptoms. preclinical research. The company is located in Doylestown, Sirtuin-based antivirals also could help treat the opportunistic Pennsylvania. They’ve raised funds from the National Institutes viruses that infect immunocompromised patients. The of Health’s Small Business Innovation Research program and antivirals would prevent virus replication even though the from private investors.

Collaborations with industry Corporate engagement plays an essential role in developing University inventions into real-world technologies

he Dean for Research Innovation Fund for Industrial awarded funding to work with Michael O’Reirdan of Comcast Collaborations supports research collaborations that can Corporation in Philadelphia to enhance the security of the T play an essential role in making the benefits of University Internet of Things (IoT). Many IoT devices, ranging from in- research available to the public. The fund requires industry home cameras to medical implants, lack security features and a partners to provide matching funds and other opportunities to user interface for modifying the device’s software. The project speed the development of research projects with the potential for aims to develop new mechanisms for improving IoT security, societal benefit. including new machine-learning approaches to automatically identify all of the devices connected to a user’s home network, Securing the Internet of Things methods for detecting anomalous behavior, and the redesign of Nick Feamster, professor of computer science and acting IoT networks with an eye toward improving security so that if director of the Center for Information Technology Policy, has been one device becomes compromised it cannot infect others. invention.princeton.edu Celebrate Princeton Invention 2016 11 Bridging the gap University discoveries receive additional development to make them ready for use

rinceton’s Intellectual Property Accelerator Fund is awarded annually by the Office of Technology Licensing P and supports projects with the potential to become technologies or products that can benefit society. Improved wireless communication with photonics With so many smartphones and other cellular devices using today’s wireless spectrum, call and data quality can be disrupted when signals interfere. To reduce this interference, nearly all wireless devices contain a large number of filters, switches and other components that take up a large amount of space on the device’s circuit board that could instead be used for functionality and performance. A team led by Paul Prucnal, professor of electrical engineering, is developing interference-canceling technology that is cheaper, simpler and takes up less space inside the phone. The technology involves a new type of computer chip that uses light rather than electrons to process signals. The new processor, called a photonic integrated circuit (PIC), can perform nearly all the necessary communications functions at a fraction of the size integrated-circuit technology, the team has created optical filters of today’s filters and switches. The processor can be made at low as well as the necessary electronics to process fluorescent signals, cost using existing semiconductor manufacturing capabilities. allowing the simultaneous detection of thousands of different molecules. New tactic for discovering more effective antibiotics Bacteria that can resist antibiotics are a growing problem worldwide, and new families of antibiotics are sorely needed. Most clinical antibiotics in use today are derived from compounds that bacteria produce to kill other bacteria. Yet genomic research suggests that there are many more of these antibacterial compounds waiting to be discovered, encoded in rarely expressed “silent” or “cryptic” gene clusters. Assistant Professor of Chemistry Mohammad Seyedsayamdost and his team have invented a systematic method of mining these silent gene clusters for new compounds by detecting molecular signals that turn on gene expression in the clusters. The method involves screening small-molecule libraries to find ones that activate expression of the clusters, then evaluating the resulting secreted product for antibiotic activity. Cheap and portable diagnostics The ability to quickly diagnose diseases could enable health Antivirals against hepatitis B care workers to respond rapidly to emerging pathogens, Hepatitis B affects more than 2 billion people worldwide, improve patient outcomes and even change the course of an yet few patients receive adequate treatment and even fewer outbreak. Assistant Professor of Electrical Engineering Kaushik are cured. Discoveries about the life cycle of this virus, which Sengupta and his team are developing a technology to detect establishes a chronic infection of the liver, have provided insight proteins and genetic material linked to human diseases in a on a new way to attack the virus. portable and low-cost biosensor that practitioners can use in Assistant Professor of Molecular Biology Alexander Ploss and resource-limited settings. his team are working on a strategy to block the virus by targeting Sengupta and his team have miniaturized a fluorescence- enzymes in the human liver that help the virus replicate. The based system into a silicon-based technology that combines researchers will explore factors that enable the virus to maintain complex optical and electronic components into a single chronic infection, and screen libraries of small molecules to find chip that can be manufactured at low cost. Using traditional ones that can block factors essential for viral replication.

12 Celebrate Princeton Invention 2016 invention.princeton.edu New ideas in the natural sciences Early-stage research projects provide the seeds of innovation

rinceton’s Dean for Research Innovation Fund for New the Henry DeWolf Smyth Professor of Physics, and Lyman Page, Ideas in the Natural Sciences supports high-quality, early- the James S. McDonnell Distinguished University Professor in P stage research. Physics, along with colleagues from a dozen institutions around the world, are designing a new telescope near the existing A forensic approach to the Atacama Cosmology Telescope in northern Chile. study of food webs The new telescope will have 30-times more detectors than its predecessor. However, it is not easy to pack 100,000 or From buffalo to bacteria, living things coexist in networks more detectors into the telescope’s two-meter-wide focal plane of interdependency known as food webs, but pinpointing while cooling the device to near absolute zero, a necessary step their structure has been difficult. A better understanding of when measuring such small temperature fluctuations. The these networks could help manage the coexistence of wild and researchers will explore how to cool the device using numerous, domestic animals and preserve biodiversity. small hexagon-shaped cooling chambers, or cryostats, that Assistant Professor of Ecology and Evolutionary Biology operate independently so that broken ones can be swapped out Robert Pringle and his team are using a forensic approach if necessary. to explore food webs by sequencing DNA fragments in fecal samples of free-ranging African savanna animals to study their diets and the symbiotic gut bacteria that aid digestion. The goal is to characterize the food choices of animals — ranging from cows to elephants and giraffes — and to explain how differences in dietary preference enhance the ability of these species to coexist. New studies of the universe’s past The cosmic microwave background — the tiny temperature fluctuations in space left over from the Big Bang — offers a window into the origin of the universe. To boost our ability to measure these fluctuations, faculty members Suzanne Staggs,

A novel intervention to control mosquito-borne diseases With the Zika virus making headlines, international attention has turned to the issue of controlling mosquitoes. Yet traditional methods for limiting mosquito populations, such as insecticides, have environmental costs and drive the rapid evolution of resistance. If more were known about mosquito mating behaviors, according to Associate Professor of Molecular Biology Mala Murthy and Assistant Professor of Ecology and Evolutionary Biology Carolyn McBride, both in the Princeton Neuroscience Institute, it might be possible to intervene to reduce mosquito populations. The researchers will study sensory cues — acoustic, visual, gustatory and pheromonal — in Aedes aegypti mosquitoes that are important for courtship and mating, and look at the underlying neural activity for these behaviors. The researchers will use gene-editing technology to study neurons suspected of driving olfactory and auditory behaviors, with the goal of finding mosquito-control strategies.

invention.princeton.edu Celebrate Princeton Invention 2016 13 Transformative technologies Major impacts emerge from cross-disciplinary teams and diverse perspectives

upporting promising research in the sciences and A microscope that can image and engineering is the goal of Princeton’s Eric and Wendy manipulate a living cell S Schmidt Transformative Technology Fund. The fund, endowed in 2009 by Eric Schmidt, executive chairman of Google Researchers are designing and building a new type of parent company Alphabet Inc., and his wife, Wendy, enables microscope that can view a living cell’s interior in 3-D research projects that have the potential to make a major impact while simultaneously allowing investigators to manipulate in a field of science or technology. Eric Schmidt is a 1976 chromosomes and other internal structures in ways that were graduate of Princeton and a former trustee of the University. previously impossible. The microscope will allow researchers to address key mechanistic questions about how cells function, A technology to study how the infant which could lead to new discoveries about the cellular brain learns language missteps that lead to cancer, birth defects and other disorders. The project brings together the expertise of faculty Interactions with caregivers are an important part of language members in biology, chemistry and physics. It is led by development in infants and young children, yet traditional MRI- Assistant Professor of Molecular Biology Sabine Petry based brain scanners can record only one person at a time and and Professor of Chemistry Haw Yang, together with don’t permit movement, a problem when studies involve infants. Joshua Shaevitz, associate professor of physics and the Under the Schmidt Fund, Princeton researchers will work to Lewis-Sigler Institute for Integrative Genomics. develop a safe and portable imaging system that can measure Current technologies for 3-D high-resolution imaging neural activity in two brains simultaneously. typically require that cells be killed and fixed in place. Led by Elise Piazza, an associate research scholar in the Methods for examining molecular activities inside the cell Princeton Neuroscience Institute, the project will let researchers tend to be conducted using large numbers of molecules. The study the neural underpinnings of human interaction, with a new microscope would fill a much-needed gap: an instrument focus on finding out what goes on in the brains of infants and that can view the molecules and structures inside the cell in their caregivers during communication in natural settings. real time. The new technology also will enable investigators Instead of functional magnetic resonance imaging (fMRI), the to push or pull on these structures using light in the form of system will use functional near-infrared spectroscopy (fNIRS), a laser, or using a new technology, developed by Yang, called which measures neural activity using low-intensity light photon nudging. delivered via a cap worn on the head, allowing participants to This ability to manipulate structures inside a cell sit up and move naturally during communication. while viewing the results with the microscope is entirely “The ability to study communication in a natural setting new, Shaevitz said. “This technology would enable could revolutionize the study of how infants develop language researchers to explore the mechanical forces that we and shed light on what goes wrong in communication disorders know operate inside the cell but that we haven’t been such as autism,” Piazza said. Her co-investigators are Uri able to study directly,” he said. Hasson, associate professor of psychology and the Princeton Neuroscience Institute, and Lauren Emberson and Casey Lew- Williams, assistant professors of psychology and co-directors of the Princeton Baby Lab.

Elise Piazza, Casey Lew-Williams, Uri Hasson and Haw Yang, Joshua Shaevitz and Sabine Petry Lauren Emberson

14 Celebrate Princeton Invention 2016 invention.princeton.edu Inventors FY16

A list of Princeton inventions by current and The Production and Generation of Radionuclides From Deuterium- Deuterium (D-D) and Deuterium-Tritium (D-T) Moderated and former members of the University research Non-Moderated Fusion Reactions for Medical, Industry and community for fiscal year 2016 Research Purposes (D) George Ascione, Adam Cohen, Charles Gentile

Key: D = Disclosure A = Application P = Patent L = License August, David Faculty member or lead inventor Trust Architecture and Related Methods (A) David August, Jordan Fix, Soumyadeep Ghosh Invention Title + Invention Status (D, A, P, L) All inventors, alphabetical by last name Austin, Robert High Efficiency Microfluidic Purification of Stem Cells to Improve Transplants (A) Aksay, Ilhan Robert Austin, Curt Civin, James Sturm Conducting Elastomers (A) Ilhan Aksay, Kevin Sallah Methods and Devices for High Throughput Purification (A) Robert Austin, Yu Chen, Curt Civin, Joseph D’Silva, James Sturm Electrohydrodynamically Formed Structures of Carbonaceous Material (A) Methods and Systems for Processing Particles (A) Ilhan Aksay, Valerie Alain-Rizzo, Michael Bozlar, David Bozym, Daniel Robert Austin, Yu Chen, Curt Civin, Joseph D’Silva, Michael Grisham, Dabbs, Nicholas Szamreta, Cem Ustundag James Sturm Graphene Dispersions (A) Microfluidic System for Cell Processing Using Deterministic Ilhan Aksay, Sezen Gurdag, Jeffrey Kaczmarczyk, Sibel Korkut Punckt, Deniz Kormaz Lateral Displacement Arrays for Cell Separation and Washing, and an Incubator for Cell Incubation (D) Printed Electronics (P) Robert Austin, Yu Chen, James Sturm Ilhan Aksay, Chuan-Hua Chen, Katherine Chiang, John Crain, Sibel Korkut Punckt, John Lettow, Robert Prud’homme Nanochannel Arrays and Their Preparation and Use for High Throughput Macromolecular Analysis (A) Robert Austin, Han Cao, Stephen Chou, Jonas Tegenfeldt, Zhaoning Yu Arnold, Craig A Three-Dimensional (3-D) Tissue Scaffold With Cell On-Chip Microfluidic Processing of Particles (A) Alignment (D) Robert Austin, Yu Chen, Curt Civin, Joseph D’Silva, Michael Grisham, Craig Arnold, Stephen Bandini, Jeffrey Schwartz, Joshua Spechler James Sturm

Design and Use of an Acoustically Tunable Beam Shaping Post Geometry Designs for High Throughput Separation Apparatus (L) of Nucleated Cells From Blood With Deterministic Lateral Craig Arnold, Euan McLeod, Alexandre Mermillod-Blondin Displacement Arrays (D) Robert Austin, Joseph D’Silva, James Sturm Device for Harvesting Mechanical Energy Through a Piezoelectrochemical Effect (A) Post Geometry Designs for High Throughput Separation Craig Arnold, John Cannarella of Nucleated Cells From Blood With Deterministic Lateral Displacement Arrays (D, A) Device for Mechanically Detecting Anomalous Battery Operation (A) Robert Austin, Joseph D’Silva, James Sturm Craig Arnold, John Cannarella, Xinyi Liu

Electrolytes for Magnesium-Ion Batteries (A) Avalos, José Craig Arnold, Jake Herb, Carl Nist-Lund Light Activated Gene Transcription of Metabolic Enzymes Halide-Ion Free Electrolytes for Magnesium-Ion Batteries (D, A) for Metabolic Pathway Tuning and Induction of Promoter Cascades (D) Craig Arnold, Jake Herb, Carl Nist-Lund José Avalos, Jared Toettcher, Evan Zhao

Ascione, George Optical Control of Transcription of Metabolic Enzymes for Tuning of Engineered Metabolic Pathways and Induction of Promoter Production of Radionuclide Molybdenum 99 in a Distributed and Cascades (A) In Situ Fashion (P) José Avalos, Jared Toettcher, Evan Zhao George Ascione, Adam Cohen, Charles Gentile invention.princeton.edu Celebrate Princeton Invention 2016 15 Back, Henning Device and Method for Testing Underground Argon (A) Henning Back

Barstow, Buz Highly Complete, Non-Redundant Gene Disruption Collections (A) Merck is excited to continue our third Oluwakemi Adesina, Isao Anzai, Buz Barstow, Michael Baym, Lev Shaket year of support for the Celebrate Knockout Sudoku: A Technology for Rapid, Low-Cost Princeton Invention reception. We Construction of Highly Complete, Non-Redundant Gene Disruption Collections (D) “value the event as a way to celebrate Oluwakemi Adesina, Isao Anzai, Buz Barstow, Michael Baym, Lev Shaket recent successes in science with our

Bassler, Bonnie existing collaborators and build new Heterocycle Analogs of CAI-1 as Agonists of Quorum Sensing in relationships across the research Vibrio (A) ecosystem at Princeton. Bonnie Bassler, Lark Perez, Martin Semmelhack Ian Davies Molecules and Compositions That Inhibit Gram Negative Bacteria and Their Uses (A) Executive Director, Chemistry, Merck & Co., Inc. Bonnie Bassler, Knut Drescher, Laura Miller Conrad, Colleen O’Loughlin, Martin Semmelhack, Albert Siryaporn

Novel Antimicrobial Compositions and Methods of Use (A) Bonnie Bassler, Nina Hoyland-Kroghsbo, Jon Paczkowski

Small Molecule Antagonists of Bacterial Quorum-Sensing Receptors (P) Bonnie Bassler, Colleen O’Loughlin, Lee Swem, Scott Ulrich The Proper Geometry for Conical X-ray Crystal Spectrographs and Novel Experimental Arrangements for the Spectroscopy of Laser- Small Molecule Potentiation of Phage Antimicrobial Activity Produced Plasmas and Other Small (Point-Like) X-ray” Sources (D) for Use in Medical, Industrial, Agricultural, and Food Safety Manfred Bitter, Luis Delgado-Aparicio, Philip Efthimion, Kenneth Hill, Applications (D) Novimir Pablant Bonnie Bassler, Nina Hoyland-Kroghsbo, Jon Paczkowski

Surfaces Comprising Attached Quorum Sensing Modulators (A) Botstein, David Bonnie Bassler, Minyoung Kim, Tom Muir, Howard Stone, Aishan Zhao Systems for Induction of Gene Expression and Protein Depletion in Yeast (P) Bernevig, B. Andrei David Botstein, Robert McIsaac, Marcus Noyes, Sanford Silverman Magnetic Topological Nanowires (A) B. Andrei Bernevig, Ali Yazdani Brangwynne, Clifford Optogenetic Tool for Rapid and Reversible Clustering of Berry, II, Michael Proteins (D, A) Clifford Brangwynne, Yongdae Shin, Jared Toettcher System and Methods for Facilitating Pattern Recognition (A) Michael Berry, II Buschman, Timothy Bitter, Manfred Adaptive Cognitive Prosthetic and Applications Thereof (A) Timothy Buschman A Multi-Cone X-ray Imaging Bragg Crystal Spectrometer (D, A) Manfred Bitter, Luis Delgado-Aparicio, Philip Efthimion, Lan Gao, Kenneth Hill, Novimir Pablant Carey, Jannette A New Class of Focusing Crystal Surfaces for the Bragg A Method for Devising Protein Purification Protocols (D) Spectroscopy of High-Density Plasmas and Small (Point-Like) Jannette Carey, Anda Trifan, Patricia Weber X-ray Sources (A) Manfred Bitter, Luis Delgado-Aparicio, Philip Efthimion, Kenneth Hill, Novimir Pablant Carrow, Brad

A Novel Precise Proton Range Diagnostic for Proton Therapy Tri(1-Adamantyl)Phosphine and Applications Thereof (A) Treatment (D, A) Brad Carrow, Liye Chen Manfred Bitter, Philip Efthimion, Lan Gao, Kenneth Hill, Dale Meade Tri(1-Adamantyl)Phosphine Ligand for Improved Transition Metal Novel Objective for EUV Microscopy, EUV Lithography, and X-ray Catalysis (D, L) Imaging (P) Brad Carrow, Liye Chen Manfred Bitter, Philip Efthimion, Kenneth Hill

16 Celebrate Princeton Invention 2016 invention.princeton.edu Carter, Emily Composite Nanoparticle Structures for Chemical and Biological Sensing (A) Multi-Color Light Emitting Diode and Intermediate Band Solar Stephen Chou, Wei Ding Cells Based on Co-Ni Oxide (A) Nima Alidoust, Emily Carter Microfluidic Sensors With Enhanced Optical Signals (A) Stephen Chou, Ruoming Peng, Chao Wang Three Dimensional Hole Transport in Nickel Oxide by Alloying With MgO or ZnO for Use as P-Type Transparent Conducting Nanochannel Arrays and Their Preparation and Use for High Oxides (D, A) Throughput Macromolecular Analysis (A) Nima Alidoust, Emily Carter Robert Austin, Han Cao, Stephen Chou, Jonas Tegenfeldt, Zhaoning Yu

Plasmonic Nanocavity Array Sensors for Analyte Detection Cava, Robert Enhancement and Methods for Making and Using of the Same (A) Electronic Interconnects and Devices With Topological Surface Hao Chen, Stephen Chou States and Methods for Fabricating Same (A) Rapid and Sensitive Analyte Measurement Assay (A) Robert Cava, Nai-Phuan Ong, Ali Yazdani Stephen Chou, Liangcheng Zhou Electronic Interconnects and Devices With Topological Surface States and Methods for Fabricating Same (P) Structures for Enhancement of Local Electric Field, Light Absorption, Light Radiation, Material Detection and Methods for Robert Cava, Nai-Phuan Ong, Ali Yazdani Making and Using of the Same (A) Gigantic Surface Lifetime of an Intrinsic Topological Insulator (A) Stephen Chou, Wendi (Jason) Li Robert Cava, M. Zahid Hasan, Madhab Neupane, SuYang Xu Systems and Methods for Personalized Sample Analysis (A) Stephen Chou Uses of the Titanic Magneto-Resistance (XMR) in WTe2 and Devices Based on the Effect as well as an Advanced Synthesis

Method for Making High Quality WTe2 Samples and Controlling the XMR Effect (A) Choueiri, Edgar Mazhar Ali, Zaheer Ali, Robert Cava A Method for Measuring Low-Noise Acoustical Impulse Responses at High Sampling Rate (A) Braxton Boren, Edgar Choueiri, Rahulram Sridhar, Joseph Tylka Caylor, Kelly Loudspeakers With Position Tracking (D) Solid Phase Extraction for Removal of Alcohols in Waters Extracted From Plants (D, A) Edgar Choueiri, Anthony Hooley, Richard Topliss, Paul Windle Kelly Caylor, Elliot Chang, Adam Wolf Spectrally Uncolored Optimal Crosstalk Cancellation for Audio Through Loudspeakers (P, L) Chirik, Paul Edgar Choueiri Base Metal Catalyzed Borylation of Arenes and Aromatic System and Method for Producing Head-Externalized 3-D Audio Heterocycles (A, L) Through Headphones (A, L) Paul Chirik, Jennifer Obligacion, Margaret Scheuermann, Scott Semproni Edgar Choueiri

Dehydrogenative Silylation and Crosslinking Using Pyridinediimine Cobalt Carboxylate Catalysts (A) Chyba, Christopher Roy Aroop, Julie Boyer, Paul Chirik, Johannes Delis, Kenrick Lewis, Electric Power Generation From Earth’s Rotation Through Its Own Christopher Schuster Magnetic Field (A) Christopher Chyba, Kevin Hand Hydroboration and Borylation With Cobalt Catalysts (A) Paul Chirik, Tianning Diao, Renyuan (Pony) Yu Cohen, Adam Iron and Cobalt Catalyzed Hydrogen Isotope Labeling of Organic Compounds (A, L) Production of Radionuclide Molybdenum 99 in a Distributed and Paul Chirik, Renyuan (Pony) Yu In Situ Fashion (P) George Ascione, Adam Cohen, Charles Gentile

Chou, Stephen The Production and Generation of Radionuclides From Deuterium- Deuterium (D-D) and Deuterium-Tritium (D-T) Moderated and Analyte Detection Enhancement by Targeted Immobilization, Non-Moderated Fusion Reactions for Medical, Industry and Surface Amplification, and Pixelated Reading and Analysis (A) Research Purposes (D) Stephen Chou, Liangcheng Zhou George Ascione, Adam Cohen, Charles Gentile

Assay Enhancement by Selective Deposition and Binding on Amplification Structures (A) Cohen, Samuel Stephen Chou System and Method for Small, Clean, Steady-State Fusion Assay Structures and Enhancement by Selective Modification and Reactors (A) Binding on Amplification Structures (A) Matthew Chu Cheong, Samuel Cohen Stephen Chou invention.princeton.edu Celebrate Princeton Invention 2016 17 Cristea, Ileana A New Class of Focusing Crystal Surfaces for the Bragg Spectroscopy of High-Density Plasmas and Small (Point-Like) Modulators of Sirtuins as Inhibitors of Human X-ray Sources (A) Cytomegalovirus (A) Manfred Bitter, Luis Delgado-Aparicio, Philip Efthimion, Kenneth Hill, Ileana Cristea, Emre Koyuncu, Thomas Shenk Novimir Pablant Sirt4 Lipoamidase Activity and Uses Thereof (A) A Novel Precise Proton Range Diagnostic for Proton Therapy Ileana Cristea, Todd Greco, Rommel Mathias, Adam Oberstein, Treatment (D, A) Thomas Shenk Manfred Bitter, Philip Efthimion, Lan Gao, Kenneth Hill, Dale Meade

Cuff, Paul Novel Objective for EUV Microscopy, EUV Lithography, and X-ray Imaging (P) Root ORAM: Practical and Secure Random Access Memory (D, A) Manfred Bitter, Philip Efthimion, Kenneth Hill Paul Cuff, Prateek Mittal, Sameer Wagh Plasma Incinerator System for the Reduction and Processing of Bulk Materials (D) Dabbs, Daniel Philip Efthimion, Charles Gentile, Kenneth Silber Electrohydrodynamically Formed Structures of Carbonaceous The Proper Geometry for Conical X-ray Crystal Spectrographs and Material (A) Novel Experimental Arrangements for the Spectroscopy of Laser- Ilhan Aksay, Valerie Alain-Rizzo, Michael Bozlar, David Bozym, Produced Plasmas and Other Small (Point-Like) X-ray Sources (D) Daniel Dabbs, Nicholas Szamreta, Cem Ustundag Manfred Bitter, Luis Delgado-Aparicio, Philip Efthimion, Kenneth Hill, Novimir Pablant Darrow, Douglass A Method of Choosing the Optimal Position, Orientation, and Estes, Lyndon Acceptance of a Fast Ion Loss Detector or Collector in a Tokamak (D) Automated and Accurate Geometric and Radiometric Correction Douglass Darrow of UAS-Collected Orthophotos (D, A) Savannah Du, Lyndon Estes, Eric Principato

Delgado-Aparicio, Luis Feamster, Nick A Multi-Cone X-ray Imaging Bragg Crystal Spectrometer (D, A) Manfred Bitter, Luis Delgado-Aparicio, Philip Efthimion, Lan Gao, Software Defined Internet Exchange Point (iSDX) (D) Kenneth Hill, Novimir Pablant Nick Feamster

A New Class of Focusing Crystal Surfaces for the Bragg Spectroscopy of High-Density Plasmas and Small (Point-Like) Fisch, Nathaniel X-ray Sources (A) Manfred Bitter, Luis Delgado-Aparicio, Philip Efthimion, Kenneth Hill, Controlling of Hot Spot Location of Compressing Gas via Novimir Pablant Spinning (D) Nathaniel Fisch, Vasily Geyko The Proper Geometry for Conical X-ray Crystal Spectrographs and Novel Experimental Arrangements for the Spectroscopy of Laser- Mass Separation by Neutral Polarization Effects (D) Produced Plasmas and Other Small (Point-Like) X-ray Sources (D) Nathaniel Fisch, Ian Ochs Manfred Bitter, Luis Delgado-Aparicio, Philip Efthimion, Kenneth Hill, Novimir Pablant Mass Separation Through Biased Drifts in Collision Gradients (D) Nathaniel Fisch, Ian Ochs

Dogariu, Arthur X-ray Burst Generation and Control Through Sudden Viscous Dissipation in Compressing Plasma (D) Detection Systems and Methods Using Coherent Anti-Stokes Raman Spectroscopy (P) Seth Davidovits, Nathaniel Fisch Arthur Dogariu

Systems and Methods for Lasing From a Molecular Gas (P) Fleischer, Jason Arthur Dogariu, James Michael, Richard Miles Method and Apparatus for Enhancement of Ultrasound Images by Selective Differencing (A) Jason Fleischer, Jen-Tang Lu Dong, John Automated Testing Instrument for Verification of Complex Quantum Information Processing and Computation via Direct Computational Systems (D, A) Imaging (D) John Dong, Hans Schneider, Gretchen Zimmer Jason Fleischer, Chien-Hung Lu, Matthew Reichert, Xiaohang Sun

Efthimion, Philip Florescu, Marian A Multi-Cone X-ray Imaging Bragg Crystal Spectrometer (D, A) Non-Crystalline Materials Having Complete Photonic, Electric or Manfred Bitter, Luis Delgado-Aparicio, Philip Efthimion, Lan Gao, Phononic Band Gaps (A) Kenneth Hill, Novimir Pablant Marian Florescu, Paul Steinhardt, Salvatore Torquato

18 Celebrate Princeton Invention 2016 invention.princeton.edu Gao, Lan A Multi-Cone X-ray Imaging Bragg Crystal Spectrometer (D, A) Manfred Bitter, Luis Delgado-Aparicio, Philip Efthimion, Lan Gao, Kenneth Hill, Novimir Pablant

A Novel Precise Proton Range Diagnostic for Proton Therapy The Office of Technology Licensing is Treatment (D, A) a force that gives Princeton’s faculty Manfred Bitter, Philip Efthimion, Lan Gao, Kenneth Hill, Dale Meade and students the confidence to pursue Garcia, Benjamin entrepreneurship and technology “ Sequence-Specific Extraction and Analysis of DNA-Bound transfer. These areas are very different Proteins (P) than scholarly research, but essential Johannes Dapprich, Benjamin Garcia, Gary LeRoy for realizing its impact. The office is Gelperin, Alan a bridge between the way scholarly Sphere of Life (D) research is done at Princeton and the Alan Gelperin practical realities — both bureaucratic and legal — of technology transfer. Gentile, Charles Naveen Verma Plasma Incinerator System for the Reduction and Processing of Bulk Materials (D) Associate Professor of Electrical Engineering Philip Efthimion, Charles Gentile, Kenneth Silber

Production of Radionuclide Molybdenum 99 in a Distributed and In Situ Fashion (P) George Ascione, Adam Cohen, Charles Gentile

Non-Crystalline Materials Having Complete Photonic, Electronic The Production and Generation of Radionuclides From Deuterium- or Phononic Bandgaps (P) Deuterium (D-D) and Deuterium-Tritium (D-T) Moderated and Marian Florescu, Paul Steinhardt, Salvatore Torquato Non-Moderated Fusion Reactions for Medical, Industry and Research Purposes (D) ” George Ascione, Adam Cohen, Charles Gentile Floudas, Christodoulos Transition-Edge Sensor X-ray Fluorescence (TES-XRF) for High Methods of Separating Molecules (A) Resolution Material Identification (D, A) Eric First, Christodoulos Floudas, M. M. Faruque Hasan Charles Gentile, Christopher Tully

Forrest, Stephen Gerakis, Alexandros High Efficiency Organic Photovoltaic Cells Employing Hybridized Mixed-Planar Heterojunctions (P) Active Protection of Optical Surfaces From Contaminations (D) Stephen Forrest, Barry Rand, Soichi Uchida, Jiangeng Xue Alexandros Gerakis, Alexsandr Merzhevskiy, Yevgeny Raitses, Vladislav Vekselman

Freedman, Michael Car Seat/Cabin Ejection System for Autonomous Road Vehicles (D) System and Method for Improving Streaming Video via Better Buffer Management (D, A) Alexandros Gerakis Matvey Arye, Michael Freedman Gitai, Zemer Galbiati, Cristiano Compounds Having Antibacterial Activity and Methods of Use (A) Detector, Three-Dimensional Direct Positron Imaging Unit, Zemer Gitai, Hahn Kim, Maxwell Wilson and Method to Estimate the Differential of the Radiation Dose Provided to Cancer Cells and Healthy Tissues During Inhibiting the Colonization, Growth and Dispersal of Pathogenic Hadrotherapy (D, A) Bacteria in Healthcare Devices and Patients Through Surface Cristiano Galbiati Chemistry Treatments and Fluid Flow Control (A) Zemer Gitai, Minyoung Kim, Yi Shen, Albert Siryaporn, Howard Stone

Gammie, Alison Regulation of Pathogenic Virulence by Surface Mechanical Synthetic Lethal Targeting of Mismatch Repair Defective Cells (A) Properties (A) Alison Gammie, Hahn Kim, Irene Ojini Zemer Gitai, Sherry Kuchma, George O’Toole, Albert Siryaporn

invention.princeton.edu Celebrate Princeton Invention 2016 19 Gmachl, Claire Novel Objective for EUV Microscopy, EUV Lithography and X-ray Imaging (P) High Peak Power Quantum Cascade Superluminescent Manfred Bitter, Philip Efthimion, Kenneth Hill Emitter (A) Nyan Aung, Claire Gmachl, Mei Chai Zheng The Proper Geometry for Conical X-ray Crystal Spectrographs and Novel Experimental Arrangements for the Spectroscopy of Laser- Single-Mode Quantum Cascade Lasers With Enhanced Tuning Produced Plasmas and Other Small (Point-Like) X-ray Sources (D) Range (P) Manfred Bitter, Luis Delgado-Aparicio, Philip Efthimion, Kenneth Hill, Claire Gmachl, Peter Liu, Mei Chai Zheng Novimir Pablant

Gomez, Michael Hultmark, Marcus Self-Aligning Mirror Mechanism for Transmission Line Offset Bending Beam Velocity Sensor (D, A) Correction (D, A) Clayton Byers, Yuyang Fan, Matthew Fu, Marcus Hultmark Cara Bagley, Michael Gomez, Benjamin Tobias, Ali Zolfaghari Bending Filament Velocity Sensor (A) Clayton Byers, Yuyang Fan, Matthew Fu, Marcus Hultmark Groves, John Elastic Filament Velocity Sensor (A) A Method for Efficient, One-Step, Fluorination of Bio-Active Clayton Byers, Yuyang Fan, Matthew Fu, Marcus Hultmark Molecules and Building Blocks Using Fluoride Ion and a Non-Heme Manganese Catalyst (D) Fast Response Humidity Sensor (L) Xinyi Chen, John Groves Gilad Arwatz, Yuyang Fan, Marcus Hultmark, Margit Vallikivi

C-Halogen Bond Formation (A) Fast Response Temperature Sensor (A, L) John Groves, Xiongyi Huang, Wei Liu Gilad Arwatz, Carla Bahri, Yuyang Fan, Marcus Hultmark

Compositions and Methods for Hydrocarbon Functionalization (A) Liquid-Infused Surfaces Featuring Reduced Drag Characteristics, Nicholas Boaz, George Fortman, John Groves, Thomas Brent Gunnoe and Methods for Fabricating the Same (A) Matthew Fu, Marcus Hultmark, Ian Jacobi, Brian Rosenberg, Alexander Iron Porphyrazines as Efficient, Catalytic and Scalable Method Smits, Howard Stone, Jason Wexler to Produce Chlorine Dioxide (A) John Groves, Roy Xiao Nanowires Integration for Real-Time Compensation (A, L) Gilad Arwatz, Marcus Hultmark Isotopic Fluorination and Applications Thereof (A) Xinyi Chen, John Groves Jaworski, Michael Targeted, Metal-Catalyzed Fluorination of Complex Compounds Concept for Reducing Hall Thruster Chamber Wall Erosion With With Fluoride Ion via Decarboxylation (A) Lithium Vapor Shielding (A) John Groves, Xiongyi Huang Michael Jaworski, Igor Kaganovich, Robert Kaita, Yevgeny Raitses

Electrical Detector for Liquid Metal Leaks (A) Hasan, M. Zahid Michael Jaworski, Jacob Schwartz Gigantic Surface Lifetime of an Intrinsic Topological Insulator (A) Use of Liquid Electrodes for Magnetohydrodynamic Power Robert Cava, M. Zahid Hasan, Madhab Neupane, SuYang Xu Generation Applications (A) Method for Production and Identification of Weyl Semimetal (A) Michael Jaworski Nasser Alidoust, Ilya Belopolski, M. Zahid Hasan, Shuang Jia, Madhab Neupane, SuYang Xu Jha, Niraj Methods to Make and Identify a Weyl Semimetal (D) CABA: Continuous Authentication Based on BioAura (D, A) Nasser Alidoust, Ilya Belopolski, M. Zahid Hasan, Shuang Jia, Madhab Niraj Jha, Arsalan Nia, Anand Raghunathan, Susmita Sur-Kolay Neupane, SuYang Xu Fine-Grain Dynamically Reconfigurable FPGA Architecture (A) Niraj Jha, Ting-Jung Lin, Wei Zhang Hill, Kenneth Hardware/Software Architecture for Improving the Safety of A Multi-Cone X-ray Imaging Bragg Crystal Spectrometer (D, A) Implantable and Wearable Medical Devices (D, A) Manfred Bitter, Luis Delgado-Aparicio, Philip Efthimion, Lan Gao, Niraj Jha, Younghyun Kim, Anand Raghunathan, Vijay Raghunathan Kenneth Hill, Novimir Pablant Hybrid Nanotube/CMOS Dynamically Reconfigurable Architecture A New Class of Focusing Crystal Surfaces for the Bragg and System Therefor (P) Spectroscopy of High-Density Plasmas and Small (Point-Like) Niraj Jha, Li Shang, Wei Zhang X-ray Sources (A) Manfred Bitter, Luis Delgado-Aparicio, Philip Efthimion, Kenneth Hill, Tracking a Smartphone User Around the World (D) Novimir Pablant Xiaoliang Dai, Niraj Jha, Prateek Mittal, Arsalan Nia

A Novel Precise Proton Range Diagnostic for Proton Therapy Vibration-based Secure Side Channel for Medical Devices (A) Treatment (D, A) Niraj Jha, Younghyun Kim, Woo Suk Lee, Vijay Raghunathan Manfred Bitter, Philip Efthimion, Lan Gao, Kenneth Hill, Dale Meade

20 Celebrate Princeton Invention 2016 invention.princeton.edu Kaganovich, Igor Khodak, Andrei Concept for Reducing Hall Thruster Chamber Wall Erosion With A Neutral Beam Pole Shield With Copper Plates and Serviceable Lithium Vapor Shielding (A) Molybdenum Inserts (D) Michael Jaworski, Igor Kaganovich, Robert Kaita, Yevgeny Raitses Andrei Khodak, Peter Titus, Irving Zatz

Neutral Beam Pole Shield (A) Kahn, Antoine Andrei Khodak, Peter Titus, Irving Zatz N-Doping of Organic Semiconductors by Bis-Metallosandwich Compounds (P) Kim, Hahn Stephen Barlow, Song Guo, Antoine Kahn, Seth Marder, Swagat Mohapatra, Yabing Qi, Kim Sang-Bok Compounds Having Antibacterial Activity and Methods of Use (A) Zemer Gitai, Hahn Kim, Maxwell Wilson Systems and Methods for Producing Low Work Function Electrodes (P) Improved SHMT Inhibitors (D, A) Canek Fuentes-Hernandez, Antoine Kahn, Bernard Kippelen, Seth Marder, Gregory Ducker, Jonathan Ghergurovich, Hahn Kim, Joshua Rabinowitz Jens Meyer, Jae Won Shim, Yinhua Zhou SHMT Inhibitors (A, L) Gregory Ducker, Jonathan Ghergurovich, Hahn Kim, Joshua Rabinowitz Kaita, Robert Synthetic Lethal Targeting of Mismatch Repair Defective Cells (A) Concept for Reducing Hall Thruster Chamber Wall Erosion With Alison Gammie, Hahn Kim, Irene Ojini Lithium Vapor Shielding (A) Michael Jaworski, Igor Kaganovich, Robert Kaita, Yevgeny Raitses Korennykh, Alexei Identification and Sensitive Detection of Immune Marker RNAs Kang, Yibin Generated by the Action of RNase L (D) Agents, Compositions and Methods for the Treatment of Jesse Donovan, Alexei Korennykh Metastatic and Chemoresistant Cancers (A) Mark Esposito, Yibin Kang Methods of Monitoring RNase L Activity (A) Jesse Donovan, Alexei Korennykh ALDH1a3 as a Therapeutic Target in Metastatic and Drug- Resistant Breast Cancer (D) Reporters for Detection of the Human Innate Immune Messenger (A) Mark Esposito, Yibin Kang Alisha Chitrakar, Jesse Donovan, Alexei Korennykh Cell Lines With MTDH KD or KO and Rescue Expression of WT or Reporters for Detection of the Human Innate Immune Messenger MT MTDH or SND1 (D) 2-5A for Research and Diagnostic Purposes (D, A) Yibin Kang, Minhong Shen, Liling Wan, Yong Wei Alisha Chitrakar, Jesse Donovan, Alexei Korennykh Expression Constructs for Various Mutants Forms of MTDH and SND1 for In Vivo Analysis Through Transient Expression in Lamb, Kevin Cells (D) Yibin Kang, Minhong Shen, Liling Wan, Yong Wei Drone Detection, Video Feed Interception and Pilot Locating System (A) Gene Expression Profile Dataset of Cell Lines or Tissues With Kevin Lamb Different MTDH or SND1 Status (D) Yibin Kang, Liling Wan, Yong Wei Lee, Ruby In Vitro and In Vivo Assays to Test MTDH and SND1 Function in Implicit User Authentication With Smartphone and Smartwatch Tumor Initiation, Growth and Treatment Resistance (D) Sensors (D, A) Yibin Kang, Liling Wan, Yong Wei Ruby Lee, Wei-han Lee

Jagged 1 as a Marker and Therapeutic Target for Breast Cancer Bone Metastasis (A) Levine, Michael Yibin Kang, Nilay Sethi A Simple Multiplexing ChIP-Seq Assay for Transcription Factors Methods of Identifying and Treating Poor-Prognosis Cancers (A) and Chromatin Landscape (D) Kai Chen, Michael Levine Guohong Hu, Yibin Kang

MicroRNAs as Functional Mediators and Biomarkers of Bone Metastasis (A) Li, Genyuan Brian Ell, Yibin Kang Data Driven Assessment and Property Prediction of Complex Multivariate Systems Utilizing High Dimensional Model MTDH KO, Conditional KO and Transgenic Mice (D) Representation (HDMR) (D) Yibin Kang, Liling Wan Genyuan Li, Herschel Rabitz, Xi Xing

invention.princeton.edu Celebrate Princeton Invention 2016 21 Meggers, Forrest Dehumidification of Air by Liquid Desiccant Across Membrane (A) Forrest Meggers, Jovan Pantelic, Eric Teitelbaum

Spherical-Motion Average Radiant Temperature Sensor (A) Forrest Meggers, Jake Read, Eric Teitelbaum Entrepreneurship the ‘Princeton way’ is being embraced warmly by Merzhevskiy, Alexsandr the University community and our Active Protection of Optical Surfaces From Contaminations (D) neighboring ecosystems. As Princeton Alexandros Gerakis, Alexsandr Merzhevskiy, Yevgeny Raitses, “ Vladislav Vekselman entrepreneurs keep pushing, pivoting and persisting, they broaden the Miles, Richard pathways for the University to serve Systems and Methods for Lasing From a Molecular Gas (P) the nation and humanity. Arthur Dogariu, James Michael, Richard Miles Mung Chiang Mittal, Prateek Arthur LeGrand Doty Professor of Electrical Engineering; Director, Keller Center; Inaugural Root ORAM: Practical and Secure Random Access Memory (D, A) Chair, Princeton Entrepreneurship Council Paul Cuff, Prateek Mittal, Sameer Wagh

Tracking a Smartphone User Around the World (D) Xiaoliang Dai, Niraj Jha, Prateek Mittal, Arsalan Nia

Muir, Tom Loo, Yueh-Lin (Lynn) Design of a Split Intein With Exceptional Protein Splicing Activity (D, A) Single-Junction Organic Solar Cells Utilizing Ultraviolet-Absorbing Materials and Producing Open-Circuit Voltages Above 1.4 V (A) Tom Muir, Neel Shah, Adam Stevens Nicholas Davy, Yueh-Lin (Lynn) Loo, Melda Sezen ” Nucleosome Assays to Identify Inhibitors of Histone Lysine Use of Ultraviolet-Absorbing Materials as the Active Constituents Demethylases (D) in an Organic Solar Cell That Produces a Single-Junction Open- David Bennett, Zachary Brown, Christian Fischer, Tom Muir, Manuel Muller, Circuit Voltage Above 1.4 V (D) Benjamin Nicholson, Stuart Shumway, Brooke Swalm Nicholas Davy, Yueh-Lin (Lynn) Loo, Melda Sezen Phosphohistidine Mimetics and Antibodies to Same (A) Jung-Min Kee, Tom Muir, Rob Oslund MacMillan, David Surfaces Comprising Attached Quorum Sensing Modulators (A) Decarboxylative Conjugate Additions and Applications Thereof (A) Bonnie Bassler, Minyoung Kim, Tom Muir, Howard Stone, Aishan Zhao David MacMillan, Stefan McCarver, Daniel Novoa

Murphy, Coleen Majeski, Richard Biomarkers of Oocyte Quality (A) A Method to Distill Hydrogen Isotopes From Lithium (D, A) Coleen Murphy Richard Majeski

McAlpine, Michael Ong, Nai-Phuan 3-D Printed Active Electronic Materials and Devices (A) Electronic Interconnects and Devices With Topological Surface Yong Lin Kong, Michael McAlpine States and Methods for Fabricating Same (A) Robert Cava, Nai-Phuan Ong, Ali Yazdani 3-D Printed Patient-Specific Conduits for Complex Peripheral Nerve Injury (A) Electronic Interconnects and Devices With Topological Surface Blake Johnson, Michael McAlpine States and Methods for Fabricating Same (P) Robert Cava, Nai-Phuan Ong, Ali Yazdani

Meade, Dale Pablant, Novimir A Novel Precise Proton Range Diagnostic for Proton Therapy Treatment (D, A) A Multi-Cone X-ray Imaging Bragg Crystal Spectrometer (D, A) Manfred Bitter, Lan Gao, Philip Efthimion, Kenneth Hill, Dale Meade Manfred Bitter, Luis Delgado-Aparicio, Philip Efthimion, Lan Gao, Kenneth Hill, Novimir Pablant

22 Celebrate Princeton Invention 2016 invention.princeton.edu A New Class of Focusing Crystal Surfaces for the Bragg A Silicon Photonic Integrated Circuit for Radio-Frequency Self- Spectroscopy of High-Density Plasmas and Small (Point-Like) Interference Cancellation (D, A, L) X-ray Sources (A) Matthew Chang, Paul Prucnal, Alexander Tait Manfred Bitter, Luis Delgado-Aparicio, Philip Efthimion, Kenneth Hill, Novimir Pablant Multibeam Radio Frequency Photonic Beamformer Using a Multi- Signal Slow Light Time Delay Unit (A) The Proper Geometry for Conical X-ray Crystal Spectrographs and John Chang, Matthew Chang, Paul Prucnal Novel Experimental Arrangements for the Spectroscopy of Laser- Produced Plasmas and Other Small (Point-Like) X-ray Sources (D) Optical Counter Phase Modulation Method of RF Interference Manfred Bitter, Luis Delgado-Aparicio, Philip Efthimion, Kenneth Hill, Cancellation (L) Novimir Pablant Konstantin Kravtsov, Paul Prucnal, John Suarez

System and Method for Photonic Processing (A) Pai, Vivek Mitchell Nahmias, Paul Prucnal, Bhavin Shastri, Alexander Tait Virtual Address Pager and Method for Use With a Bulk Erase Memory (P) Prud’homme, Robert Anirudh Badam, Vivek Pai Co-Encapsulation of Antimicrobials and Antimicrobial Adjuvants in Nanocarriers (A) Pelczer, Istvan Hoang Lu, Robert Prud’homme Nutritional Supplement/Feed Formula and Methods of Use Nano-Encapsulation Using GRAS Materials and Applications Thereof to Inhibit Development of Osteochondrosis Dissecans (OCD) Lesions (A, L) Thereof (A) Robert Prud’homme, Nikolas Weissmueller Istvan Pelczer, Sarah Ralston Nanoparticle Vaccine Compositions and Applications Thereof (A) Petta, Jason Robert Prud’homme, Ruth Rosenthal, Nikolas Weissmueller Overlapping Gate Architecture for Linear Arrays of Si/SiGe Printed Electronics (P) Quantum Dots (D) Ilhan Aksay, Chuan-Hua Chen, Katherine Chiang, John Crain, Sibel Korkut Thomas Hazard, Jason Petta, David Zajac Punckt, John Lettow, Robert Prud’homme

Semiconductor Quantum Dot Device and Method for Forming a Process for Encapsulating Soluble Biologics, Therapeutics and Scalable Linear Array of Quantum Dots (A) Imaging Agents (D, A) Thomas Hazard, Jason Petta, David Zajac Chester Markwalter, Robert Pagels, Robert Prud’homme

Ploss, Alexander Rabinowitz, Joshua A Method for Identifying Host-Targeting Anti-Hepatitis B Virus Compositions and Methods for Enhancing Immunotherapy (A) Compounds (D) Joshua Rabinowitz Alexander Ploss, Benjamin Winer Dietary Supplements and Compositions for Treating Cancer (A, L) Generation of a Cell Line Susceptible to Hepatitis B and Delta Jing Fan, Jurre Kamphorst, Joshua Rabinowitz, Craig Thompson, Viruses (A) Jianbin Ye Alexander Ploss, Benjamin Winer Electronic Inhaler for Delivery of Pharmaceuticals via Heating and Vaporization (D) Poor, H. Vincent Joshua Rabinowitz Disintegrated Channel Estimation in Filter-and-Forward Relay Enhancement of Immunotherapy via Genetic Manipulation of the Networks (D, A) Tumor Metabolic Environment (D) Kao-Peng Chou, Jia-Chin Lin, H. Vincent Poor Joshua Rabinowitz Initial Synchronization Exploiting Inherent Diversity for the LTE Folate-Dependent NADPH Production (L) Sector Search Process (D, A) Gregory Ducker, Jing Fan, Joshua Rabinowitz Jia-Chin Lin, H. Vincent Poor, Yu-Ting Sun Improved SHMT Inhibitors (D, A) System and Method for Initial Ranging in Wireless Communication Systems (P) Gregory Ducker, Jonathan Ghergurovich, Hahn Kim, Joshua Rabinowitz Michele Morelli, H. Vincent Poor, Luca Sanguinetti Inhibition of Glycerol-3-Phosphate Acyltransferase (GPAT) and System and Method for Lossy Source-Channel Coding at the Associated Enzymes for Treatment of Viral Infections (A) Application Layer (P) Sean Liu, Joshua Rabinowitz, Thomas Shenk Giuseppe Caire, Maria Fresia, H. Vincent Poor, Ozgun Bursalioglu Yilmaz Inhibition of Glycerol-3-Phosphate Acyltransferase (GPAT) and Associated Enzymes for Treatment of Viral Infections (P) Prucnal, Paul Sean Liu, Joshua Rabinowitz, Thomas Shenk A III-V Photonic Integrated Circuit for Radio-Frequency Self- Inhibitors of Long and Very Long Chain Fatty Acid Metabolism Interference Cancellation (D, A, L) as Broad Spectrum Anti-Virals (A) Matthew Chang, Paul Prucnal Emre Koyuncu, Joshua Rabinowitz, Thomas Shenk invention.princeton.edu Celebrate Princeton Invention 2016 23 Inhibitors of Long and Very Long Chain Fatty Acid Metabolism Thin-Film Devices With Light Extraction Layers (A) as Broad Spectrum Anti-Virals (P) Tae-Wook Koh, Barry Rand Emre Koyuncu, Joshua Rabinowitz, Thomas Shenk Use of an Organic Underlayer to Enable Crystallization of Lipid Scavenging in RAS Cancers (A) Disordered Organic Thin Films (D, A) Justin Cross, Jurre Kamphorst, Joshua Rabinowitz, Craig Thompson Michael Fusella, Barry Rand, Siyu Yang

Method to Produce Virus in Cultured Cells (A) Emre Koyuncu, Joshua Rabinowitz, Thomas Shenk Rodriguez, Alejandro Overlap Optimization of Nonlinear Frequency Conversion in Multi- Methods and Devices for Controlled Drug Vaporization (A) Mode Cavities (A) Joshua Rabinowitz Steven Johnson, Zin Lin, Marko Loncar, Alejandro Rodriguez Methods and Materials for Producing Polyols and Electron Rich Compounds (A) Romalis, Michael Sarah Johnson, Fabien Letisse, Joshua Rabinowitz, Yi-Fan Xu A Device Using Polarized K Atoms to Measure Magnetic Fields Methods to Enhance the Yield of Infectious Human With Higher Sensitivity Than Best Existing Devices of This Cytomegalovirus and Varicella Zoster Virus in Cultured Cells (P) Type (L) Emre Koyuncu, Joshua Rabinowitz, Thomas Shenk Joel Allred, Ioannis Kominis, Tom Kornack, Rob Lyman, Michael Romalis

NADPH Production by the 10-Formyl-THF Pathway, and Its Use Atomic Magnetometer for RF Detection (L) in the Diagnosis and Treatment of Disease (D, A) Michael Romalis, Karen Sauer, Igor Savukov, Scott Seltzer Gregory Ducker, Jing Fan, Ling Liu, Joshua Rabinowitz Pulsed Scalar Atomic Magnetometer (D, A, L) SHMT Inhibitors (A, L) Andrei Baranga, Haifeng Dong, Michael Romalis Gregory Ducker, Jonathan Ghergurovich, Hahn Kim, Joshua Rabinowitz

Treatment of Viral Infections by Modulation of Host Cell Scherer, George Metabolic Pathways (A) Aluminum Phosphate Consolidant for Stone (D, A) Bryson Bennett, Joshua Munger, Joshua Rabinowitz, Thomas Shenk Enrico Sassoni, George Scherer

Rabitz, Herschel Schneider, Hans Data Driven Assessment and Property Prediction of Complex Automated Testing Instrument for Verification of Complex Multivariate Systems Utilizing High Dimensional Model Computational Systems (D, A) Representation (HDMR) (D) John Dong, Hans Schneider, Gretchen Zimmer Genyuan Li, Herschel Rabitz, Xi Xing Distributed Intelligence Architecture for Real-Time Control, Hybrid, High Power Laser System (D, A) Protection and Instrumentation Systems (D, A) Alexei Goun, Herschel Rabitz Hans Schneider, Greg Tchilinguirian Optimal Control in the Sciences Over Vast Length and Time Scales (OptiSci) (D) Schwartz, Jeffrey Herschel Rabitz A Three-Dimensional (3-D) Tissue Scaffold With Cell Alignment (D) Raitses, Yevgeny Craig Arnold, Stephen Bandini, Jeffrey Schwartz, Joshua Spechler

Active Protection of Optical Surfaces From Contaminations (D) Nanoparticle Surface Modification (P) Alexandros Gerakis, Alexsandr Merzhevskiy, Yevgeny Raitses, Jeffrey Schwartz, Christopher Traina Vladislav Vekselman Patterning a Shape Memory Polymer Scaffold for Spatial Control Concept for Reducing Hall Thruster Chamber Wall Erosion With of Cell Growth on Non-Planar Surfaces (D) Lithium Vapor Shielding (A) Lily Adler, Stephen Bandini, Gregory Harris, Alomi Parikh, Jeffrey Schwartz, Michael Jaworski, Igor Kaganovich, Robert Kaita, Yevgeny Raitses Jean Schwarzbauer

Patterning of Fragile or Non-Planar Surfaces for Cell Alignment (A) Rand, Barry Lily Adler, Stephen Bandini, Gregory Harris, Alomi Parikh, Jeffrey Schwartz, A Solid-State Organic Intermediate Band Solar Cell Based on Jean Schwarzbauer, Joshua Spechler Principles of Triplet-Triplet Annihilation (D, A) Scaffolds for Tissues and Uses Thereof (A) YunHui Lin, Barry Rand Jeffrey Schwartz, Jean Schwarzbauer High Efficiency Organic Photovoltaic Cells Employing Hybridized Mixed-Planar Heterojunctions (P) Schwarzbauer, Jean Stephen Forrest, Barry Rand, Soichi Uchida, Jiangeng Xue Patterning a Shape Memory Polymer Scaffold for Spatial Control Method of Forming and Applications of Metal Halide Perovskite of Cell Growth on Non-Planar Surfaces (D) Films With Small Crystallite Size (D, A) Lily Adler, Stephen Bandini, Gregory Harris, Alomi Parikh, Jeffrey Schwartz, Ross Kerner, Barry Rand, Zhengguo Xiao Jean Schwarzbauer

24 Celebrate Princeton Invention 2016 invention.princeton.edu Patterning of Fragile or Non-Planar Surfaces for Cell Alignment (A) Silber, Kenneth Lily Adler, Stephen Bandini, Gregory Harris, Alomi Parikh, Jeffrey Schwartz, Plasma Incinerator System for the Reduction and Processing Jean Schwarzbauer, Joshua Spechler of Bulk Materials (D) Scaffolds for Tissues and Uses Thereof (A) Philip Efthimion, Charles Gentile, Kenneth Silber Jeffrey Schwartz, Jean Schwarzbauer Silverman, Sanford Semmelhack, Martin Systems for Induction of Gene Expression and Protein Depletion in Yeast (P) Heterocycle Analogs of CAI-1 as Agonists of Quorum Sensing David Botstein, Robert McIsaac, Marcus Noyes, Sanford Silverman in Vibrio (A) Bonnie Bassler, Lark Perez, Martin Semmelhack Smits, Alexander Molecules and Compositions That Inhibit Gram Negative Bacteria and Their Uses (A) Liquid-Infused Surfaces Featuring Reduced Drag Characteristics, Bonnie Bassler, Knut Drescher, Laura Miller Conrad, Colleen O’Loughlin, and Methods for Fabricating the Same (A) Martin Semmelhack, Albert Siryaporn Matthew Fu, Marcus Hultmark, Ian Jacobi, Brian Rosenberg, Alexander Smits, Howard Stone, Jason Wexler

Sengupta, Kaushik Soboyejo, Winston Frequency-Reconfigurable Integrated Power Amplifier and Transmitter Architectures (D, A) Reversible-Magnetic, Self-Erasing Chalkboard (D, A) Chandrakanth Chappidi, Kaushik Sengupta Aarav Chavda, Isaac Ilivicky, Winston Soboyejo

Shenk, Thomas Sorensen, Erik CMV-GFP Reporter (D, L) Acceptorless Catalytic Dehydrogenation (A) Thomas Shenk, Dai Wang Erik Sorensen, Julian West

Inhibition of Glycerol-3-Phosphate Acyltransferase (GPAT) and C-H Bond Fluorination With Visible Light Uranyl Associated Enzymes for Treatment of Viral Infections (A) Photocatalysts (A) Sean Liu, Joshua Rabinowitz, Thomas Shenk Erik Sorensen, Julian West

Inhibition of Glycerol-3-Phosphate Acyltransferase (GPAT) and Associated Enzymes for Treatment of Viral Infections (P) Steingart, Daniel Sean Liu, Joshua Rabinowitz, Thomas Shenk Alkaline Battery Electrolyte Useful for a Rechargeable Alkaline Electrochemical Cell (A) Inhibitors of Long and Very Long Chain Fatty Acid Metabolism Mylad Chamoun, Greg Davies, Benjamin Hertzberg, Ying Meng, as Broad Spectrum Anti-Virals (A) Daniel Steingart Emre Koyuncu, Joshua Rabinowitz, Thomas Shenk Hyper-Dendritic Nanoporous Zinc Foam Anodes, Methods of Inhibitors of Long and Very Long Chain Fatty Acid Metabolism Producing the Same, and Methods for Their Use (A) as Broad Spectrum Anti-Virals (P) Mylad Chamoun, Greg Davies, Benjamin Hertzberg, Andrew Hsieh, Emre Koyuncu, Joshua Rabinowitz, Thomas Shenk Daniel Steingart

Method to Produce Virus in Cultured Cells (A) Membrane-Free Non-Flowing Single Cell Zinc Bromine Battery Emre Koyuncu, Joshua Rabinowitz, Thomas Shenk With Bromine-Trapping Composite Carbon Foam Electrode (D, A) Shaurjo Biswas, Thomas Hodson, Robert Mohr, Aoi Senju, Methods to Enhance the Yield of Infectious Human Daniel Steingart Cytomegalovirus and Varicella Zoster Virus in Cultured Cells (P) Emre Koyuncu, Joshua Rabinowitz, Thomas Shenk Steinhardt, Paul Modulators of Sirtuins as Inhibitors of Human Hyperuniform and Nearly Hyperuniform Random Network Cytomegalovirus (A) Materials (A) Ileana Cristea, Emre Koyuncu, Thomas Shenk Miroslav Hejna, Paul Steinhardt, Salvatore Torquato

Sirt4 Lipoamidase Activity and Uses Thereof (A) Non-Crystalline Materials Having Complete Photonic, Electric Ileana Cristea, Todd Greco, Rommel Mathias, Adam Oberstein, or Phononic Band Gaps (A) Thomas Shenk Marian Florescu, Paul Steinhardt, Salvatore Torquato

Treatment of Viral Infections by Modulation of Host Cell Non-Crystalline Materials Having Complete Photonic, Electronic, Metabolic Pathways (A) or Phononic Bandgaps (P) Bryson Bennett, Joshua Munger, Joshua Rabinowitz, Thomas Shenk Marian Florescu, Paul Steinhardt, Salvatore Torquato

invention.princeton.edu Celebrate Princeton Invention 2016 25 Stone, Howard On-Chip Microfluidic Processing of Particles (A) Robert Austin, Yu Chen, Curt Civin, Joseph D’Silva, Michael Grisham, A Localized Coating Method With a Binary Mixture and Polymer James Sturm Additive (A) Francois Boulogne, Hyoungsoo Kim, Howard Stone Post Geometry Designs for High Throughput Separation of Nucleated Cells From Blood With Deterministic Lateral Control of the Drying Stress in Colloidal Suspensions by Choosing Displacement Arrays (D) a Distribution of Particle Sizes (D) Robert Austin, Joseph D’Silva, James Sturm Francois Boulogne, Yong Lin Kong, Janine Nunes, Howard Stone Post Geometry Designs for High Throughput Separation Gating of a Mechanosensitive Channel by Fluid Flows (D, A) of Nucleated Cells From Blood With Deterministic Lateral Gary Marple, On Shun Pak, Howard Stone, Shravan Veerapaneni, Displacement Arrays (D, A) Yuan Nan Young Robert Austin, Joseph D’Silva, James Sturm

Inhibiting the Colonization, Growth and Dispersal of Pathogenic System and Method for 3-D Position and Gesture Sensing of Bacteria in Healthcare Devices and Patients Through Surface Human Hand (A) Chemistry Treatments and Fluid Flow Control (A) Yingzhe Hu, Liechao Huang, James Sturm, Naveen Verma, Sigurd Wagner Zemer Gitai, Minyoung Kim, Yi Shen, Albert Siryaporn, Howard Stone System and Method for 3-D Position and Gesture Sensing of Injectable Hydrogels From Microfiber Suspensions (A) Human Hand (A) Stefano Guido, Janine Nunes, Antonio Perazzo, Howard Stone Yingzhe Hu, Liechao Huang, Warren Rieutort-Louis, Josue Sanz-Robinson, James Sturm, Naveen Verma, Sigurd Wagner Liquid-Infused Surfaces Featuring Reduced Drag Characteristics, and Methods for Fabricating the Same (A) Matthew Fu, Marcus Hultmark, Ian Jacobi, Brian Rosenberg, Suckewer, Szymon Alexander Smits, Howard Stone, Jason Wexler Compact Plasma Laser for Dermatology Applications (D) Method for Uniform Deposition of Particles on Absorbing Szymon Suckewer Hydrogels (A) Francois Boulogne, Francois Bernard Ingremeau, Laurent Limat, Intrastromal Corneal Reshaping Method and Apparatus for Howard Stone Correction of Refractive Errors Using Ultra-Short and Ultra- Intensive Laser Pulses (A) Particle Motion in Suspensions Driven by Contact With Gas (D, A) Taehee Han, Peter Hersh, Szymon Suckewer Orest Shardt, Suin Shim, Sangwoo Shin, Howard Stone, Patrick Warren Tattoo Removal With Two Laser Beams via Multi-Photon Reduction of the Drying Stress in Colloidal Suspensions by Processes (P) Choosing a Distribution of Particle Sizes (A) Szymon Suckewer Francois Boulogne, Yong Lin Kong, Janine Nunes, Howard Stone

Surfaces Comprising Attached Quorum Sensing Modulators (A) Tchilinguirian, Greg Bonnie Bassler, Minyoung Kim, Tom Muir, Howard Stone, Aishan Zhao Distributed Intelligence Architecture for Real-Time Control, System and Method for Emulsion Breaking and Phase Separation Protection and Instrumentation Systems (D, A) by Droplet Adhesion (A) Hans Schneider, Greg Tchilinguirian Haosheng Chen, Jiang Li, Howard Stone Tian, Haoshu Sturm, James Do People Answer Online Questionnaires Carelessly? Assessing High Efficiency Microfluidic Purification of Stem Cells to Improve the Quality of Online Questionnaires Through Data Mining (D) Transplants (A) Qikun Niu, Haoshu Tian, Yiqiao (Joe) Zhong Robert Austin, Curt Civin, James Sturm

Methods and Devices for High Throughput Purification (A) Titus, Peter Robert Austin, Yu Chen, Curt Civin, Joseph D’Silva, James Sturm A Neutral Beam Pole Shield With Copper Plates and Serviceable Molybdenum Inserts (D) Methods and Devices for Multi-Step Cell Purification (D, A) Andrei Khodak, Peter Titus, Irving Zatz Lee Aurich, Curt Civin, Khushroo Gandhi, Michael Grisham, Alison Skelley, James Sturm, Anthony Ward Neutral Beam Pole Shield (A) Methods and Devices for Multi-Step Cell Purification and Andrei Khodak, Peter Titus, Irving Zatz Concentration (A) Lee Aurich, Curt Civin, Khushroo Gandhi, Michael Grisham, Alison Skelley, Tobias, Benjamin James Sturm, Anthony Ward Self-Aligning Mirror Mechanism for Transmission Line Offset Methods and Systems for Processing Particles (A) Correction (D, A) Robert Austin, Yu Chen, Curt Civin, Joseph D’Silva, Michael Grisham, Cara Bagley, Michael Gomez, Benjamin Tobias, Ali Zolfaghari James Sturm

Microfluidic System for Cell Processing Using Deterministic Toettcher, Jared Lateral Displacement Arrays for Cell Separation and Washing, and an Incubator for Cell Incubation (D) Cancer Cell Therapy (D) Robert Austin, Yu Chen, James Sturm Alexander Goglia, Jared Toettcher, Maxwell Wilson

26 Celebrate Princeton Invention 2016 invention.princeton.edu Light Activated Gene Transcription of Metabolic Enzymes A Strong Machine-Learning Classifier Integrated Directly Within for Metabolic Pathway Tuning and Induction of Promoter a Standard 6T SRAM Array (D, A) Cascades (D) Naveen Verma, Zhuo Wang, Jintao Zhang José Avalos, Jared Toettcher, Evan Zhao Multiplying Analog to Digital Converter and Method (A) Optical Control of Transcription of Metabolic Enzymes for Tuning Naveen Verma, Zhuo Wang, Jintao Zhang of Engineered Metabolic Pathways and Induction of Promoter Cascades (A) System and Method for 3-D Position and Gesture Sensing of José Avalos, Jared Toettcher, Evan Zhao Human Hand (A) Yingzhe Hu, Liechao Huang, James Sturm, Naveen Verma, Sigurd Wagner Optogenetic Cell Therapy (D) Alexander Goglia, Jared Toettcher, Maxwell Wilson System and Method for 3-D Position and Gesture Sensing of Human Hand (A) Optogenetic Tool for Rapid and Reversible Clustering of Yingzhe Hu, Liechao Huang, Warren Rieutort-Louis, Josue Sanz-Robinson, Proteins (D, A) James Sturm, Naveen Verma, Sigurd Wagner Clifford Brangwynne, Yongdae Shin, Jared Toettcher

Viola, Michael Torquato, Salvatore Adjustable Portable Tensile Testing Machine (A) Density Enhancement Methods and Compositions (A) Michael Viola Adam Hopkins, Salvatore Torquato

Hyperuniform and Nearly Hyperuniform Random Network Wagner, Sigurd Materials (A) Miroslav Hejna, Paul Steinhardt, Salvatore Torquato Hybrid Layers for Use in Coatings on Electronic Devices or Other Articles (P) Non-Crystalline Materials Having Complete Photonic, Electric Julia Brown, Lin Han, Ruiqing Ma, Prashant Mandlik, Jeffrey Silvernail, or Phononic Band Gaps (A) Sigurd Wagner Marian Florescu, Paul Steinhardt, Salvatore Torquato System and Method for 3-D Position and Gesture Sensing of Non-Crystalline Materials Having Complete Photonic, Electronic, Human Hand (A) or Phononic Bandgaps (P) Yingzhe Hu, Liechao Huang, James Sturm, Naveen Verma, Sigurd Wagner Marian Florescu, Paul Steinhardt, Salvatore Torquato System and Method for 3-D Position and Gesture Sensing of Human Hand (A) Tromp, Jeroen Yingzhe Hu, Liechao Huang, Warren Rieutort-Louis, Josue Sanz-Robinson, James Sturm, Naveen Verma, Sigurd Wagner Medical Imaging Based on Full Waveform Inversion or Adjoint Tomography (D) Etienne Bachmann, Jeroen Tromp White, Claire Nanoparticles to Mitigate Microcracking in Alkali-Activated Troyanskaya, Olga Materials (A) Claire White Method of Use of Targeting Specific Antigen Combinations Using Engineered Multi-Receptor Immune Cells for Cancer Therapy (D) Wendell Lim, Olga Troyanskaya, Benjamin VanderSluis Woolley, Robert

Systems and Methods for Targeting Cancer Cells (A) Dual Tokamak With Alternating Current Inductive Plasma Wendell Lim, Olga Troyanskaya, Benjamin VanderSluis Formation and Sustainment (D) Robert Woolley

Tully, Christopher Wysocki, Gerard Transition-Edge Sensor X-ray Fluorescence (TES-XRF) for High Resolution Material Identification (D, A) Cavity-Enhanced Heterodyne Faraday Rotation Spectroscopy Charles Gentile, Christopher Tully Using a Conventional Two-Mirror or Novel Three-Mirror Cavity Design (A) Brian Brumfield, Gerard Wysocki Vekselman, Vladislav Chemical Detection Based on Laser Spectroscopic Sensing of Active Protection of Optical Surfaces From Contaminations (D) Anomalous Molecular/Atomic Dispersion (L) Alexandros Gerakis, Alexsandr Merzhevskiy, Yevgeny Raitses, Vladislav Damien Weidmann, Gerard Wysocki Vekselman Chirped Laser Dispersion Spectroscopy Sensitivity Booster (D, A) Yifeng Chen, Genevieve Plant, Gerard Wysocki Verma, Naveen A Machine-Learning Classifier Based on Comparators for Direct Frequency Stabilized Cavity Ring Down Faraday Rotation Inference on Analog Sensor Data (D, A) Spectroscopy (A) Helen Waechter, Jonas Westberg, Gerard Wysocki Naveen Verma, Zhuo Wang invention.princeton.edu Celebrate Princeton Invention 2016 27 Frequency Stabilized Cavity Ring Down Faraday Rotation Spectroscopy — Experimental Procedures and Data Analysis Methods (D) Helen Waechter, Jonas Westberg, Gerard Wysocki

Simultaneous Ranging and Remote Chemical Sensing Utilizing Optical Dispersion or Absorption Spectroscopy (A) Andreas Hangauer, Gerard Wysocki

Yao, Nan Patterned Charge Generation Using Torsional Mode Atomic Force Microscopy (D, A) Wei Cai, Nan Yao

Scanning Probe Lithography Using Non-Raster Trajectories (D, A) Wei Cai, Nan Yao

Yazdani, Ali Electronic Interconnects and Devices With Topological Surface States and Methods for Fabricating Same (A) Robert Cava, Nai-Phuan Ong, Ali Yazdani

Electronic Interconnects and Devices With Topological Surface States and Methods for Fabricating Same (P) Robert Cava, Nai-Phuan Ong, Ali Yazdani

Magnetic Topological Nanowires (A) B. Andrei Bernevig, Ali Yazdani

Zatz, Irving A Neutral Beam Pole Shield With Copper Plates and Serviceable Molybdenum Inserts (D) Andrei Khodak, Peter Titus, Irving Zatz

Neutral Beam Pole Shield (A) Andrei Khodak, Peter Titus, Irving Zatz

Zhong, Yiqiao (Joe) Do People Answer Online Questionnaires Carelessly? Assessing the Quality of Online Questionnaires Through Data Mining (D) Qikun Niu, Haoshu Tian, Yiqiao (Joe) Zhong

Zimmer, Gretchen Automated Testing Instrument for Verification of Complex Computational Systems (D, A) John Dong, Hans Schneider, Gretchen Zimmer

Zolfaghari, Ali Self-Aligning Mirror Mechanism for Transmission Line Offset Correction (D, A) Cara Bagley, Michael Gomez, Benjamin Tobias, Ali Zolfaghar

Key: D = Disclosure A = Application P = Patent L = License Faculty member or lead inventor Invention Title + Invention Status (D, A, P, L) All inventors, alphabetical by last name

28 Celebrate Princeton Invention 2016 invention.princeton.edu Nondiscrimination Statement In compliance with Title IX of the Education Amendments of 1972, Section 504 of the Rehabilitation Act of 1973, Title VI of the Civil Rights Act of 1964 and other federal, state, and local laws, Princeton University does not discriminate on the basis of age, race, color, sex, sexual orientation, gender identity, religion, national or ethnic origin, disability, or veteran status in any phase of its employment process, in any phase of its admission or financial aid programs, or other aspects of its educational programs or activities. The vice provost for institutional equity and diversity is the individual designated by the University to coordinate its efforts to comply with Title IX, Section 504 and other equal opportunity and affirmative action regulations and laws. Questions or concerns regarding Title IX, Section 504 or other aspects of Princeton’s equal opportunity or affirmative action programs should be directed to the Office of the Vice Provost for Institutional Equity and Diversity, Princeton University, 205 Nassau Hall, Princeton, NJ 08544 or (609) 258-6110.

Published by the Office of the Dean for Research Text by Catherine Zandonella and John Greenwald Editorial and design services provided by the Office of Communications Photography by Denise Applewhite, Sameer A. Khan, Christopher Lillja, C. Todd Reichart, Elle Starkman, Frank Wojciechowski; page 10 (laser) courtesy of TRUMPF Group; page 10 (figure) by James Sturm and Robert Austin; page 11 courtesy of FORGE Life Sciences; page 12 (optical fibers) © leungchopan/123RF Stock Photo; page 12 (circuit board) courtesy of Kaushik Sengupta; page 13 (mosquito) © masuti/123RF Stock Photo Cover illustration by Stephanie Dalton Cowan Copyright © 2016 by The Trustees of Princeton University

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