Synthetic Ozonide Drug Candidate OZ439 Offers New Hope for a Single-Dose Cure of Uncomplicated Malaria
Synthetic ozonide drug candidate OZ439 offers new hope for a single-dose cure of uncomplicated malaria Susan A. Charmana, Sarah Arbe-Barnesb, Ian C. Bathurstc, Reto Brund,e, Michael Campbella, William N. Charmana, Francis C. K. Chiua, Jacques Cholletd,e, J. Carl Craftc, Darren J. Creeka, Yuxiang Dongf, Hugues Matileg, Melanie Maurerd,e, Julia Morizzia, Tien Nguyena, Petros Papastogiannidisd,e, Christian Scheurerd,e, David M. Shackleforda, Kamaraj Sriraghavanf, Lukas Stingelina, Yuanqing Tangf, Heinrich Urwylerh, Xiaofang Wangf, Karen L. Whitea, Sergio Wittlind,e, Lin Zhouf, and Jonathan L. Vennerstromf,1 aCentre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia; bFulcrum Pharma Developments Ltd., Hemel Hempstead, Hertfordshire HP1 1JY, United Kingdom; cMedicines for Malaria Venture, CH-1215 Geneva, Switzerland; dSwiss Tropical and Public Health Institute, CH-4002 Basel, Switzerland; eUniversity of Basel, CH-4051 Basel, Switzerland; fCollege of Pharmacy, University of Nebraska Medical Center, Omaha, NE 68198-6025; gF. Hoffmann-La Roche Ltd., CH-4070 Basel, Switzerland; and hBasilea Pharmaceutica Ltd., CH-4058 Basel, Switzerland Edited by Thomas E. Wellems, National Institutes of Health, Bethesda, MD, and approved January 11, 2011 (received for review October 21, 2010) Ozonide OZ439 is a synthetic peroxide antimalarial drug candidate Thai-Cambodian border, and more recently, increased parasite designed to provide a single-dose oral cure in humans. OZ439 has clearance times with artesunate (AS) monotherapy, have raised successfully completed Phase I clinical trials, where it was shown to significant concerns that resistance to these agents may be be safe at doses up to 1,600 mg and is currently undergoing Phase emerging (2, 3).
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