Toward Pathway Engineering: a New Database of Genetic and Molecular
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vidul pro jets would e relized we hve not yet mde forE quene interprettion to ols inE on their lo l mhines y inteE ml nnounement of uiqqD luding sequene similrity nd grting dtses nd omputE preliminry version hs een motif serh progrmsF he tionl resoures distriuted over pulily ville through the server reeives tens of thousnds the networkF e elieve tht the qenomexet server sine of queries p er dyD oneEthird of wideErnging dtse servie heemer IWWSF he trget dte whih re from rodF elE in qenomexetD whih is jointly of the rst relese of uiqq is though the qenomexet dtse provided y the up eromputer yto er IWWTF e pln to disE servie is result of tehnologE vortory of the snstitute for triute ompt diss in ddition il developments in tpnD for ghemil eserhD uyoto niE to the servie over the snternetF exmpleD hfqi ws develop ed versity nd the rumn qenome in my l ortoryD most of the genter of snstitute of wedil dtses tht we oer origintE Pathways Binary relations KEGG Hierarchies Genes Molecules LIGAND Genome OMIM DBGET CAS Databases DNA/Protein Databases Medline pigure PX he onept of uiqq nd its reltion to hfqiF sn uiqq funtionl sp ets of genes nd moleules re represented y inry reltionsD hierrhiesD nd pthwysF e retrieved uniformly nd links he gonepts he onept of reltion nd re mde etween relted entries dedution is thus the sis in dierent dtsesF sn this of our uiqq pro jetF por gurrentlyD uiqq is omp osed lo oselyEoupled integrtionD the our logiEsed tivitiesD we of three interonneted setionsX shem or the formt of hown knowledge the pst oll orE pthwysD genesD nd moleulesD entry is orgnized y dt items tions with the pifth qenertion whih re lso linked to is left to eh dtseF his gomputer ro jet tem memE numer of existing dtses should e ontrsted with using ers in sgy nd the reserhers through hfqi @pigF PAF the sme reltionl dtse nd in the qenome snformtis eE foth oneptully nd prE enforing unied shem for serh ro jets IWWIEIWWS nd tillyD uiqq nd hfqi entries oming from mny dierE IWWTEPHHHF re tightly oupled systemsF ent souresD whih neessrily inE hfqi provides n integrted volves the pro ess of dt onE view of vrious dtses in he ehnologies versionF moleulr iologyD where the E he prolifertion of sis of integrtion is the link @iE uiqq mkes full use of the ws o on to our pproh nry reltionA etween relted dvnements in the dtse of lo ose integrtionY the link entries in dierent dtsesF sn nd networking tehnologyD inE pilities of hfqi t the uiqqD n orgnism my e luding dedutive nd o jetE mehnism of very nieE onsidered dtse of genes oriented dtsesD the multimeE lyF he textEsed hfqi sysE nd gene pro dutsD nd the link di environment of D nd tem ws esily extended to the etween them is used for synE the moile gentD tvF elE multimedi environmentD where thesizing pthwyF husD though we mintin the logiE Qh grphisD Ph grphisD nd oth uiqq nd hfqi onE sed formlism of reltion nd imges re now retrievle in tin n sp et of the dedutive dedutionD we tke prtilD the version of hfqiF dtse where new reltions exile pproh in the tul sn dditionD euse the up dte n e dedued from reltions implementtionF por exmpleD pro edure do es not involve dt stored in the dtseF we use the gyev dedutive onversionD hfqi hs een enother imp ortnt onept dtse system for exp erimentE nd will ontinue to e le to in uiqq is the hierrhy tht ing the dedution pro essD ut op e with the ever inresing represents funtionlD struturlD in the tul implementtion of numer nd volume of dily upE nd evolutionry reltionships of uiqq we hve developed our dted dtsesF genes nd moleulesF por exE own gCC lirry for mnipultE uiqq inherits ll these mpleD the degree of similrity ing inry reltions nd hierrE hfqi pilitiesF purtherE in sequenes nd Qh strutures hiesF moreD the grphis hndling of of proteins is used for lssifyE ith similr philosophyD pthwy digrms nd hromoE ing sup erfmilies nd Qh foldsF hfqi do es not dep end on some mps hs een implementE he txonomy is the lssiE ny dtse mngement sysE ed y tvF he new pilities tion of orgnismsD whih is imE temF he entire system hs of logil inferene nd simulE portnt in extending sequene een developed in houseF etuE tion re still under developmentD nd Qh struturl similrities to llyD hfqi hs its ro ots in the ut we hop e to mke the rst funtionl similritiesF hese shie sequene nlysis pkE test version ville shortlyF nd other lssitions re tkE ge tht s developed in the erly en from pproprite soures nd IWVHs in the FF xtionl snstiE implemented in uiqqF tutes of relthF hfqi ims t ht golletion ifE integrting dierent dtses hile the inry reltion nd dierent types of dt