Early Career Researchers..

In hosting this event we would like to say thank you to our industrial partners, who have helped us to shape this program so far. You have done this with dispassionate honesty and enthusiasm, which has been most welcome and encouraging to us all. It has been a steep learning curve for us and we know this is only the beginning. Be reassured that we appreciate the time you are giving and we value hearing your advice and your requests. We may not always get it right but we are genuinely committed to nurturing this partner- ship in a mutually beneficial way that will create a ‟culture of interaction with industry‟ in our institution. Our aim is that the next generation of research leaders will be able to thrive through collaboration, and will be a testament to those who dedicated time to their training.

To the academic staff and early career researchers, we would like to encourage you to take up this unique opportunity to increase your network of industrial partners, let them know your strengths and discover their needs. We are entering a new era in the history of universities and the opportunity to network with industrial partners will enable us to en- hance the impact of our research. To those in management positions, we invite you to en- gage with our help in building the InKForge portfolio of events within departments . We hope you will ensure that the early career researchers working with you take part in this process and have the opportunity to learn how it is done. Be reassured that the Early Ca- reer Group, particularly Dr Kay Guccione will be there to support you in making this hap- pen.

Finally I would like to say my personal thank you to Dr Kay Guccione, who was able to see the potential of what we were trying to achieve from the start and has been working with great passion and dedication to transform few ideas in a concrete program of work. My thanks go also to Lesley Keers, InKForge administrator, who has supported us in the or- ganization of this event with great enthusiasm.

I hope you enjoy the evening and this will be the first of many InKForge events to come. Ilaria Bellantuono Chair of the Early Career Group

Early Career Researchers..

Dr Dan Hampshire Research Associate Cardiovascular Science Dan has worked in the field of molecular genetics for approximately eleven years, specifically on its appli- cation to research into single gene disorders. His initial research focused on neuro-development disor- ders, specifically the use of molecular genetic techniques to identify and characterise genes involved in neuro-development. During this period he also undertook an industrial placement with GlaxoSmithKline as part of an MRC Industrial CASE studentship. Post-PhD Dan‟s research has focused on the inherited bleeding disorder von Willebrand disease. Specifically, his research concerns the identification of further mechanisms involved in the pathogenesis of this disorder. However, he has also developed an active inter- est into the wide natural variation of von Willebrand factor (VWF) levels in plasma and the mechanisms which could influence plasma VWF levels, including the transcriptional / miRNA regulation of the VWF gene and other genetic loci acting as modifiers.

Dr Ed Guccione Research Associate Infection & Immunity Ed is a molecular microbiologist who has worked in a number of areas of the course of a 10-year career. Ed‟s PhD was an Industrial CASE studentship with Don Whitley Scientific Ltd that focused on the funda- mental metabolism available to foodborne pathogen Campylobacter jejuni. He continued his work with the pathogen developing novel chemostat culture system for the notoriously fastidious organism, to enable reliable transcriptomic analysis through a range of robustly controlled conditions. Currently, Ed is apply- ing his molecular microbiology skills to developing a new technique for gene expression analysis of Neis- seria spp. during human colonisation. Outside of academia, Ed is a Chief Executive Officer of a local Arts Charity and its trading arm.

Dr Caroline Parkin Research Associate Biomedical Science Caroline Parkin uses zebrafish as a model for studying developmental and medical genetics, for much of the last ten years she‟s been at the Centre for Developmental and Biomedical Genetics (CDBG) at the Uni- versity of Sheffield. She can tell you (with some caveats) how the digestive system forms, and the implica- tions for the development of human birth defects and diabetes (her PhD subject); how muscle fibres de- velop, grow and fuse (a post-doc carried out at IMCB in Singapore) and how different drugs that were tested on zebrafish can be used to treat human diseases (a post-doc at CDBG). But she‟s now looking at something new: how stems cells are regulated in the adult brain, with specific emphasis on the hypothala- mus. Zebrafish provide an ideal model for this work as they readily regenerate neural tissue. In addition to her research she spends a lot of time doing outreach work, which ranges from maintaining a website about zebrafish in medical research (www.fishforscience.com) to running day-long molecular biology clas- ses for A-level students to giving a 6 minute and 40 second presentation on her work to the general public at a Pecha Kucha night

Dr Michael Trikic Research Associate Oncology Michael works in the Institute for Cancer Studies within the Department of Oncology, The Medical School, University of Sheffield. Michael has 10 years experience of working in university and commercial research laboratories and in 2005 moved to Sheffield to study for a PhD in immunology using zebrafish as a model organism, in the Department of Molecular Biology and Biotechnology. He finished his PhD in a little over 3 years and published a paper based on his findings. He then took up his current position researching the interaction between kinases and small molecule inhibitors, with the aim of developing an understanding of kinase biology in cancers and improving tumour targeting for future therapies.

Early Career Researchers Early Career Researchers..

Dr David Finger Research Fellow Chemistry David is currently a Marie Curie International Incoming Fellow (MC-IIF) at the University of Sheffield and a member of the Board of Director (BoD) of the National Postdoctoral Association (NPA). Before becoming an MC-IIF, David was an extramural NIH Ruth Kirschstein Postdoctoral Fellow at the City of Hope (COH) Beckman Research Institute near Los Angeles. David earned his B.A. in biochemistry from Ithaca College. After a three month internship in the Department of Vaccine Serology at Merck, Inc. in West Point, PA, Da- vid moved to Los Angeles to earn his doctorate in Biochemistry and Molecular Biology at University of Cali- fornia, Los Angeles (UCLA) under the direction of Professor Juli Feigon. Before becoming a member of the BoD of the NPA, David previously served as Chair (2009) and Vice Chair (2010) of the Outreach Commit- tee in addition to volunteering (2007-2009) for several other sub-committees of the Meetings Committee.

Dr Aneurin Kennerley Research Associate Psychology Aneurin is a Magnetic Resonance Physicist for the fMRI facility in the Department of Psychology. His role includes overseeing the running of MRI based experimental research in the neuro-imaging facilities within the department, and coordinating MRI research carried out in the imaging Unit including that undertaken for internal and external customers. Aneurin obtained his PhD from the University of Sheffield in 2006. In 2010 he was awarded the AstraZeneca Prize for innovative in-vivo MRI research at the British Chapter of the International Society of Magnetic Resonance in Medicine conference.

Dr Daniel Kelly Research Associate Human Metabolism Daniel completed an undergraduate degree in combined honours Human Biology and Human Psychology at Aston University in Birmingham. As part of this course he spent a year in industry working for Unilever R&D as a research assistant within a team of biomedical scientists investigating biomarkers of stress and heart health/lifestyle interventions. This placement triggered an interest in biomedical research and he spent almost two years working as a laboratory technician at Sheffield Hallam University. This led him to undertake a PhD at the same University investigating the effects of testosterone on the inflammatory pathogenesis of atherosclerosis. He is currently a postdoctoral research associate at the University of Sheffield focussing on the role of testosterone in cardiovascular disease and comorbidities such as diabe- tes and metabolic syndrome.

Dr Simon Palfreyman Research Nurse/Honorary Lecturer ScHARR Simon‟s professional background is as a registered nurse. He currently has a three year post-doctoral NIHR (National Institute for Health Research) clinical lectureship in tissue viability. The post has both a clinical component based within Sheffield Teaching Hospitals NHS Foundation Trust, and a research pro- ject which is within the field of outcome measurement. To undertake his PhD he gained a Smith and Nephew Foundation scholarship to develop a quality of life questionnaire which could be used to examine the effectiveness of treatments for venous ulceration. Simon has successfully applied for and been a co- applicant on a range of research studies within tissue viability and service delivery. He has formed re- search collaborations with Sheffield Hallam University, Sheffield University and Sheffield Teaching Hospi- tals. Simon‟s has experience of undertaking both qualitative and quantitative research. His research inter- ests are concerned with the measurement and valuation of health, particularly in relation to tissue viabil- ity/wound care.

Early Career Researchers Early Career Researchers..

Praveen Thokala Research Associate ScHARR Praveen is a health economic modeller at Health Economics and Decision Science (HEDS) in the School of Health and Related Research (ScHARR) at the University of Sheffield. He has a MASc degree from the Uni- versity of Toronto and a PhD from the University of Southampton. Since joining ScHARR, he has undertak- en cost-effectiveness modelling projects in a number of diseases areas such as diabetes, Alzheimer‟s dis- ease, cardiac disease and multiple sclerosis. He has also worked on the applicability of multi criteria deci- sion analysis (MCDA) in health technology assessment as part of a National Institute of Health and Clinical Excellence decision support unit (NICE DSU) project. He is currently the project manager for two projects (valued at £170,000), co-supervisor for three PhD students and co-leader for the “Operational Research Techniques in Health Resource Allocation” module within the Health Economics and Decision Modelling MSc.

Will English Research Fellow Oncology Will is currently a research fellow in the Cancer Research UK Tumour Microcirculation Group (CRUK TMG) led by Professor Gillian Tozer. Will joined the Faculty of Medicine, Dentistry and Health at the Uni- versity of Sheffield in May 2011. Prior to joining the CRUK TMG, Will spent three years as a British Heart Foundation Intermediate Research Fellow at the Cambridge Institute for Medical Research then four years as a senior research associate at CRUK‟s Cambridge Research Institute. During this time Will‟s research focused on the regulation of vascular biology by metalloproteinases. This has led to the development of sophisticated 3D in vitro models for the study of pericytes and fibroblasts in regulating tumour angiogene- sis. Will is currently using his expertise to study the role of these cells in tumours resistant to anti- angiogenic and vascular disrupting agents using 3D in vitro and in vivo pre-clinical models.

Gareth Richards Research Associate Human Metabolism Gareth is a director of a university spin out company Medella Therapeutics with Professor Tim Skerry. He completed his PhD in receptor pharmacology at the University of Sheffield in 2007; during the course of his PhD the underlying intellectual property (IP) of Medella Therapeutics was developed. Medella oper- ates in the area of anti-RAMP (Receptor Activity Modifying Proteins) molecules as therapies for diseases including cancer and osteoporosis. After completing his PhD Gareth was awarded a BBSRC/RSE Enter- prise Fellowship to allow him to develop the IP generated during the course of his PhD and provided the commercial training and opportunity to develop a wide network of contacts. Gareth currently splits his time between performing research in the area of RAMP pharmacology and the development of current therapeutic leads towards clinical utility and the management of Medella Therapeutics.

Dr Emma Bird Research Associate School of Clinical Dentistry Emma‟s main research interest is the aetiology of neuropathic and inflammatory pain, and the role of po- tential regulators of neuronal excitability. Emma joined the Oral Neuroscience Research group as a re- search technician in 1996, and was awarded a PhD, entitled “Immunocytochemical studies on neuromas of branches of the trigeminal nerve” in 2004. Subsequently, as a post-doctoral research associate, she has worked on a number of research projects, and worked in collaboration with GlaxoSmithKline, Pfizer and neuroscience groups in Brazil, Sweden and USA. Emma is currently leading a pilot study in a cross-faculty collaboration with colleagues in the Department of Psychology, to develop MRI techniques to examine central pain pathway responses to peripheral nerve injury in a well established pre-clinical model of chronic pain, with a view to securing future funding and establishing new industrial collaborations.

Early Career Researchers Early Career Researchers..

Dr Claire Christmas Research Associate School of Clinical Dentistry Claire joined the School of Clinical Dentistry in 2002 and completed her PhD in neuroscience entitled “Mechanisms of human dental pain” under the supervision of Professors Fiona Boissonade and Helen Rodd. Following successful completion of her PhD in 2006, Claire has been employed as a post-doctoral research associate in the Oral Neuroscience research group in the Dental School and has worked on col- laborations with various pharmaceutical companies, including GlaxoSmithKline and Renovo Ltd and has helped to develop a novel partnership with colleagues at Yale University. Claire‟s main research interests include the aetiology of neuropathic and inflammatory pain in the trigeminal system and improving nerve regeneration by the use of bio-engineered nerve conduits. Claire is currently funded on a BBSRC Industri- al Partnership award in collaboration with Pfizer Ltd investigating the role of specific chemokines in tri- geminal sensitization.

Dr Jennifer Carlring-Wright Research Associate Infection & Immunity Jennifer is a research scientist and project manager for Adjuvantix Ltd, which is a biotechnology spin out company from the University of Sheffield. She joined Adjuvantix Ltd in September 2009 after working as a post-doctoral researcher at the University of Sheffield. Her research interests include cancer immunology and vaccine development. In her current role Jennifer is the senior researcher working on a novel propri- etary adjuvant system relying on the use of anti-CD40 antibodies. During her time at Adjuvantix Ltd she has worked to provide the scientific pre-clinical data necessary for a potential clinical trial in lymphoma pa- tients. Adjuvantix Ltd is now in the process of seeking funding for such a trial. Jennifer is enjoying the man- agement and multi-tasking aspect of her current role and would like to forge links with industrial partners for future collaborations.

Dr Heather Mortiboys Research Associate Neuroscience My research interests cover mitochondrial components of neurodegenerative diseases. In particular we focus on Parkinson‟s Disease and Huntingdon‟s Disease and investigate mitochondrial function, morpholo- gy and DNA in patient tissue of these diseases. In addition I have developed a drug screening assay of mi- tochondrial function and screened compound libraries for their effect in Parkinson‟s Disease patient tis- sue

Julia Hough Graduate Research Student Human Metabolism Julia is currently working as a Histology Research Technician as well as a 2nd year PhD student in the Facul- ty of Medicine, Dentistry and Health. She received a BSc Honours degree in Biomedical Science in July 2008, after which she obtained employment at the University of Sheffield the following September within her current role as a Research Technician in the Bone Analysis Laboratory. The Bone Analysis Laboratory provides a service specialising in micro-CT scanning, sectioning, staining and histomorphometric analysis of murine bone. However, Julia is specifically employed on a programme grant funded by the charity Leu- kaemia and Lymphoma Research, which focusses upon the influence of the bone microenvironment in the disease multiple myeloma. In 2010, Julia was then offered a PhD place to identify novel molecules which may influence myeloma cell survival in bone, and those of which may provide suitable drug targets to pre- vent disease. Julia is hoping to complete her PhD by 2013, after which she would be eager to either diverge into industry, particularly drug discovery or to remain in academia as a Post-Doctoral Research Associate, investigating drug targets in myeloma or leukaemia.

Early Career Researchers Early Career Researchers..

Christina Staicu Graduate Research Student Cardiovascular Science Christina is a doctoral student in Medical Physics at the University of Sheffield and is at the final stage of thesis writing. She joined the University of Sheffield after obtaining the MEng degree in Biomaterial Sci- ence and Tissue Engineering from the Materials Science and Engineering Department. During her three years PhD she worked on the development of a processing workflow for clinical cases suspected of aortic coarctation. The core of the workflow is designed with high-level engineering algorithms but its interface is made usable by paediatric clinicians. It provides processing of non-invasive clinical data, and then, using a computational fluid dynamic model, exports the pressure drop value across thoracic aorta, the key diag- nostic element for the disease. Currently the workflow is tested for aortic coarctation studies at King‟s College London – St. Thomas Hospital (London, UK) and for aortic dissection cases at DKFZ (Heidelberg, Germany). In Hungary, last year, the software was presented at eHealth Week- a collocation of the Euro- pean Commission‟s High Level Ministerial Conference and the World of Health IT Conference & Exhibition

Iwona Zwierzak Graduate Research Student Cardiovascular Science Iwona is originally from Poland and has a MSc degree in Biomedical Engineering from the Wroclaw Univer- sity of Technology, Poland. Her Masters Thesis, at the National University of Ireland, in Galway research, was on osteoporosis. After my studies I worked for 6 months in LG Electronics in Poland as an engineer in R&D Department. A passion for science brought her to Bologna, Italy working as a researcher at the Or- thopaedic Institute Rizzoli for 2 years. She is currently a PhD student in Cardiovascular Science. Iwona‟s project is an experimental study focusing on characterization of vessel wall strain caused by stents, which may improve stent design, deployment and expansion technique. The project may result in future collabo- ration with medical device industries, which constitute a major part of the European economy.

Claudia Amatruda Graduate Research Student Cardiovascular Science Claudia‟s education has been diverse as she opted to develop various interests in different periods of her life. She attended a linguistic secondary school to deepen her skill in languages. For University she wanted to satisfy her scientific curiosity, and chose Biomedical Engineering finding the idea of helping medical practice without being a doctor appealing. Her Bachelor‟s thesis was an experimental work on carotid stents, while her Masters thesis was an experimental and computational study on indentation of soft tis- sues; the latter made her wish to improve those skills, so she opted for a PhD based on computational simulations. Her future plans are not necessarily academically-oriented as she would like to experience research finalised for the market, or even to be involved in different parts of the product design, produc- tion and marketing

Ankita Agrawal Graduate Research Student Human Metabolism Ankita is a second year PhD student in the Department of Bone Biology at the Mellanby Centre for Bone Research. She completed her graduation with honours in Zoology from Delhi University, India and her MSc was in Stem Cell and regenerative medicine at the University of Sheffield in 2008. She worked for around 2 years on a project testing the effect of specific molecular targets on the development of bone resorbing cells called osteoclasts, following which she decided to pursue a PhD on osteoclasts and a one of their cell-surface receptor, P2X7 receptor.

Industry Contributors Industry Contributors

Tony Bradshaw Co-Director HealthTech & Medicines Knowledge Transfer Network Tony Bradshaw is Co-Directors of the HealthTech and Medicines Knowledge Transfer Network (KTN). The HealthTech and Medicines KTN is a government funded initiative to support innovation in the UK, with a key focus in this case of healthcare technologies covering prevention, diagnosis, treatment and rehabilita- tion. Tony supports collaboration across the clinical, academic and industrial interface, helping to deter- mine priority needs and establish new partnerships to deliver new products and processes.

Alan Wallace Senior Independent Biochemist Alan has extensive exereince within the pre-clinical drug-discovery industry having worked as a molecular and cellular pharmacologist for Fisons, Astra and AstraZeneca. He studied Medical Biochemistry at Bir- mingham before moving to UMIST where his PhD concentrated on cAMP phosphodiesterases. After a postdoctoral fellowship back in Birmingham he moved into the pharmaceutical industry. Here he worked on a wide range of projects, including cell signalling pathways, proteases, kinases and various G-protein coupled receptors; targeting several major diseases and involving close collaboration with research sites in the UK, USA, Sweden and Canada. His work on NO synthase has led to invitations to speak at several international conferences. In addition he is a committee member at the Biochemical Society and has or- ganised many national and international scientific meetings.

Tom Ceska Director of Crystallography UCB Pharma Tom is a structural biologist specialising in protein crystallography with experience in the pharmaceutical industry, engaged in structure-based drug design. He has an interest in biophysical methods to gain un- derstanding of molecule properties as relates to function. Tom‟s goals are to improve the processes by which we identify chemical leads for our projects, helping to identify compounds that are able to pass the hurdles to become marketed drugs. Tom is engaged in protein design to enhance ability to produce ro- bust biological molecules for structural studies and potentially therapeutics.

Stuart Farrow Director GlaxoSmithKline Stuart Farrow is a director in the GlaxoSmithKline respiratory therapy area, and also visiting Professor of Experimental Therapeutics at the University of Manchester, where he currently leads a major discovery research collaboration between the University and GSK. Stuart has more than 20 years of drug discovery experience in the pharmaceutical sector, with a particular focus on inflammation and respiratory disease, and has led numerous drug discovery programmes from initial target identification and validation through to clinical proof of concept. He has more than 50 peer reviewed publications, lectures on drug discovery to MSc students at several UK universities and is regularly invited to present on target discovery and vali- dation at international respiratory disease conferences.

Edward Draper Innovations Manager JRI Orthopaedics Edward is a highly experienced Senior Innovations Manager who is entrepreneurial by nature. He has technological expertise in a diverse range of commercial products med tech and in both physical and life sciences – knowing how to exploit synergies between different markets and disciplines. With a sharp fo- cus on innovation, Edward is proactively seeking opportunities for New Product Development that com- plement the product portfolio while remaining commercially viable.

Industry Contributors Industry Contributors

Janet Fernihough Project Manager, Strategic R&D Networks Vertex Pharmaceuticals Janet is a project manager in the Strategic R&D Networks Department at Vertex, at the UK Oxfordshire site. She is responsible for the project management of drugs from discovery to proof of concept. Janet is a qualified project manager with senior management experience spanning the diverse environments of aca- demia (Oxford and Bristol Universities); small Biotech start-ups (Arthromics and Ribostem); the pharma- ceutical industry (Vertex and Novartis) and a not-for-profit independent research organisation (SBL UK c.i.c.). Janet has successfully managed large projects including the early stage activities, documentation and regulatory approval processes for a clinical oncology trial at a leading London hospital and has consid- erable expertise in establishing and maintaining national and international

Hal Ebetino Director of Discovery Warner Chilcott

Thomas Southgate Programme Leader GlaxoSmithKline Tom trained as a neuroscientist at University of Wales College of Cardiff and in Milan at the Istituto di Ri- cerche Farmacologiche „Mario Negri‟ before undertaking a PhD in gene therapy for inherited and metabol- ic disorders at University of Manchester funded by Action Medical Research. Following his studies Tom spent two years in industry at the Defence Science Technology Laboratories in Salisbury before returning to academia to complete two post doctoral positions one in haematological malignancies the other in im- munology and embryonic development at the Paterson Institute for Cancer Research. Two years ago Tom joined Biopharm R&D at GlaxoSmithKline, based in Cambridge, where he currently leads two research programme teams.

Austen Pimm Team Leader, Drug Discovery Warner Chilcott Austen Pimm received his PhD degree in Organic Chemistry at the University of Southampton in the UK. He has over 16 years of drug discovery and medicinal chemistry experience. He worked at AstraZene- ca from 1995-2011 and has, in May 2011, joined the drug discovery group at Warner Chilcott (Ireland) as a team leader. His research has primarily been focussed on inflammatory and immunosuppressive mecha- nisms with drug delivery by both oral and inhalation routes.

Sam Whitehouse Chief Operating Officer QuantuMDx Sam has over 10 years experience in both biotech, and medical devices including industrial research, managing a large portfolio of academic-industry biotech collaborations and managing UK government grant portfolios. He has set up research projects in a variety of research areas across mulitple academic disciplines. Projects range from purely academic to large multi-nationals and span multiple countries. Sam has been in Sheffield for over 13 years and has an extensive knowledge of research taking place within the N8 Universities.

Industry Contributors Industry Contributors

Tim Allsopp Neusentis Regenerative Medicine Pfizer Tim has 9 years experience in the biotech sector – founding, building, resourcing, and managing small to medium sized enterprises. Tim has vast experience leveraging public sector opportunities to resource product development strategies, managing discovery to innovation and putting innovation into practise to deliver products from the biology of human cells. Tim‟s interests and experiences also include reviewing & evaluating on behalf of others, R&D designs, experimental strategies and innovation in the international regenerative medicine sector.

Kevin Parker Industry and Commercialism Training Consultant KKI Associates Kevin trained as a chemist (at Edinburgh and Cambridge), and worked for 12 years with BP, in R&D and as a 'fast-track' commercial manager. Here he gained experience in sales management, international market- ing (literally 'selling oil to the Arabs'), and technico-economic studies in conventional and renewable ener- gy. In 1992 he left BP to graduate from London Business School's Sloan Masters Programme, with distinc- tions in entrepreneurial finance, environmental economics and international business development. Since 1994, Kevin has worked on over 250 assignments for technology based business start-ups and SME's. Kevin has delivered over 150 commercial skills training courses for start-ups, universities and research insti- tutes, and mentored over 20 teams (including several from Sheffield) in business plan competitions and investment conferences.

John Elvin Scientific External Liaison, Department of Antibody Discovery and Protein Engineering MedImmune John works for MedImmune Ltd based at Granta Park near Cambridge. MedImmune is the worldwide bio- logics business unit for AstraZeneca and was formed in 2007from the integration of the AstraZeneca ac- quisitions of Cambridge Antibody Technology (CAT) and MedImmune. Having completed his BSc in Micro- biology at the University of Bristol in 1987 he worked in a technical role in the Nuffield Department of Med- icine for two years and then and gained a D.Phil. from University of Oxford in T cell immunology in 1992 while working with Alain Townsend and Andrew McMichael in the (Weatherall) Institute of Molecular Medicine. He then held an MRC Junior Research Fellowship at the Laboratory of Molecular Biology with Michael Neuberger, in Cambridge before joining Cambridge Antibody Technology (CAT) in 1995. During his 16 years at CAT and MedImmune he has held various positions in the Research Department. John‟s ex- perience has included: use of proprietary phage display antibody libraries to isolate therapeutic antibod- ies to a range of targets; project management; biological assay development in the oncology therapeutic area and set up and management of the Hybridoma Technology Group on the Cambridge Site. His current role working in MedImmune R&D involves interaction with external scientific contacts within universities and government funded institutions with a view to exploring potential collaborations and mutually benefi- cial interactions.

David Harland Senior Medical Scientific Liaison UCB Pharma David is a field-based Senior Medical Scientific Liaison working in medical affairs at UCB Pharma in the UK. He joined UCB in June 2009 and currently provides support to the Immunology team. Before joining UCB, David was a Scientific Advisor with sanofi aventis in the UK, working in the oncology therapy area. David has also worked in a role at a medical communications agency preparing meta analysis, systematic reviews and clinical data slide decks for the pharmaceutical industry across therapy areas. Prior to his career in the pharmaceutical industry, David graduated with a BSc (Hons) in Biomedical Sciences and completed a PhD in molecular microbiology and vaccine design whilst working for the Ministry of Defence at Porton Down.

Industry Contributors Industry Contributors

Paul Cronin Director of Business Development Diamond Pharma Services Paul Cronin has a BSc in Biochemistry and an MSc in international business and management. Paul is cur- rently the Director of Business Development for Diamond Pharma Services. Diamond Pharma Services is a leading technical and scientific consulting group serving the biotechnology and pharmaceutical industry. Their emphasis is on regulatory affairs, pharmacovigilance and compliance. Paul has overall responsibility for the development, direction and implementation of Diamond Pharma‟s global marketing and business development strategy. Paul previously headed business development at the Smerud Medical Research Group which is a clinical Contract Research Organisation operating in the European area with head office in Norway and subsidiary wholly owned offices throughout Europe including Austria, Denmark, Finland, Hungary, Sweden, Poland, Russia, United Kingdom. Paul started his pharmaceutical career as a regulatory affairs consultant at ERA Consulting. During his time at ERA Consulting he was involved in evolving this into a leading international regulatory consultancy and was responsible for all of its global business develop- ment activities.

Gemma Satterthwaite Associate Director - CNSP/Neuroscience, Personalised Healthcare, Strategy, Portfolio and Per- formance AstraZeneca

Heather Bryson Development Director, New Opportunities AstraZeneca I graduated from the University of Sheffield with a first class honours degree in Pharmacology in 1994. I continued studying at the University of Sheffield and completed an ARC-funded PhD in 1998 at the Depart- ment of Human Metabolism and Clinical Biochemistry (now known as the Mellanby Centre). My thesis was entitled: "A functional link between plasminogen activator/plasmin activity and cartilage proteoglycan breakdown.” Whilst completing my thesis I spent several months working at Proctor & Gamble Pharma- ceuticals in Mason, Ohio, U.S.A. From 1999 to 2009 I worked as a Development Director in the Neurosci- ences Division of SmithKline Beecham/GlaxoSmithKline. In 2009 I took a position as a Development Direc- tor in the Neurosciences Division at Eisai Pharmaceuticals. From 2010 onwards I have been working as a Development Director (Project Leader) at AstraZeneca in the New Opportunities Innovative Medicines Unit (iMED). In this role I work on a wide variety of disease indications which fall outside the core AZ ther- apy areas. New Opportunities is a virtual iMED with a focus on asset re-positioning and externalisation. My experience in clinical research spans early and late stage clinical development from FTIH to Regulatory Submissions.

Stephen Hague Senior Field Applications Specialist LIFE Technologies Stephen provides support for the use of instrumentation/reagents and scientific techniques, to academ- ic, clinical and pharma customers to UK and European customers

Julia Petrucci R&D Innovation Associate Reckitt Benckiser Julia received a BSc in Chemical Biology from University of California, Berkeley in 2008. She then moved to the UK to complete a MSc in Analytical Chemistry with Management Studies at Kingston University. After completion of the MSc, she started working with Reckitt Benckiser helping to support a variety of brands and programmes across the business' portfolio. At present, Julia's role aims to support the research and development team in the Sexual Wellbeing platform.

University Staff University Staff

Professor Richard Jones Pro VC for Research and Innovation Richard is a physicist, with a BA and PhD from Cambridge University. Following postdoctoral work at Cor- nell University, he was an assistant lecturer, then lecturer, at Cambridge´s Cavendish Laboratory. He moved to Sheffield as a Professor of Physics in 1998, and was Head of Department from 1999-2003. His work has focused on experimental studies of the nanoscale structure and properties of polymers and bio- logical macromolecules at interfaces. He is the author of more than 120 research papers, and three books, the most recent of which is Soft Machines: nanotechnology and life, published by OUP in 2004. He was elected a Fellow of the Royal Society in 2006. He has had a long-standing interest in public engagement and the broader societal dimensions of nanotechnology; he was the co-author, with Stephen Wood, of a report published by the UK´s Economic and Social Research Council, The Social and Economic Challenges of Nanotechnology (2003). He chaired the Nanotechnology Engagement Group, a body set up by UK Gov- ernment to support the development of best practice in public engagement around nanotechnologies, and to ensure that public engagement feeds into policy and decision-making, and from 2007 to 2009 was the Senior Strategic Advisor for Nanotechnology for the Engineering and Physical Sciences Research Council.

Professor Tony Weetman Pro Vice Chancellor of the Faculty of Medicine, Dentistry and Health Tony is the Pro Vice Chancellor of the Faculty of Medicine, Dentistry and Health and Sir Arthur Hall Profes- sor of Medicine. He is also Professor of Medicine and Honorary Consultant Endocrinologist since 1991. He was MRC Training Fellow at the Welsh National School of Medicine and MRC Travelling Fellow, National Institutes of Health (NIH), USA. Previously he was Lecturer in Medicine at the University of Cambridge and Dean of the School of Medicine from 1999 – 2008. His research interests include the pathogenesis of au- toimmune endocrine disease, especially thyroid disease and current projects include the immunogenetics of Graves´ disease, the molecular characterisation of thyroid and parathyroid autoantibodies and work on autoantigen identification in vitiligo, a skin disorder found in increased frequency in Graves´ disease.

Professor Paul Hellewell Faculty Director of Research and Innovation Paul is Professor of Vascular Biology in the Dept. of Cardiovascular Science. Previously he was Head of Cell Biology at British Biotechnology in Oxford before moving back into academia as Senior Lecturer in Ap- plied Pharmacology at the National Heart and Lung Institute in London, part of Imperial College. He has held senior roles of Director of the Division of Clinical Sciences North, Director of Resources and Acting Dean in the Medical School at the University of Sheffield. His research interests include mechanisms and regulation of leukocyte endothelial transmigration.

Professor Richard Ross Director of Sheffield Health Innovation Centre Richard is Head of the Academic Unit of Diabetes, Endocrinology and Reproduction, Professor of Endocri- nology and a clinical academic. His research and clinical interests are in pituitary disease, transition endo- crinology and the late effects of cancer therapy. He has extensive experience working with industry in translational research, investigator led clinical trials and as principle investigator in large multicentre phase 3 and 4 clinical studies. Richard is responsible for directing the Sheffield Healthcare Gateway and promoting knowledge exchange in healthcare across the University of Sheffield. He is a founding director in two University of Sheffield spinout companies: Asterion Ltd and Diurnal Ltd. Asterion has developed long acting biologicals and Diurnal new endocrine hormone replacement therapies which have progressed through from preclinical to phase 2 clinical trials. These experiences have given Richard an understanding of business, the challenges of drug development, and the value of academia collaborating with industry.

University Staff University Staff

Professor Ian Douglas Head of the Graduate School of the Faculty of Medicine, Dentistry and Health and Deputy Dean of the Dental School Ian‟s research interests include pathogenic mechanisms of oral streptococci in infective endocarditis; the mechanisms of epithelial cell invasion by bacteria, particularly oral commensals and periodontal patho- gens; development of sensors for specific bacteria in such situations as wound infection or periodontitis; searching for alternative antimicrobial agents for potential therapeutic use or as surface coatings. He is also interested in interactions between oral bacteria and salivary components with a view to understand- ing how they influence oral disease and the ecology of mouth.

Professor Tim Skerry Head of the Department of Human Metabolism Tim graduated from the Royal Veterinary College in London and worked in clinical practice for 4 years, when he was awarded a Wellcome Veterinary Training Fellowship and studied for a PhD in functional ad- aptation in bone. He then which he took up a lectureship at the University of Bristol where he ran a small research group, before moving to become Professor of Biology at the University of York and subsequently Head of Basic Sciences and Vice Principal for Research at the Royal Veterinary College. Professor Skerry is now Head of the Department of Human Metabolism, Professor of Orthopaedic Biology and Chief Scien- tific Officer of Medella Therapeutics, a University spinout company with IP in cancer therapeutics. Tim's primary research interest in bone biology has been the mechanism of bone's response of bone to mechan- ical loading and the identification of therapeutic targets for anabolic bone therapies. Tim has been in- volved in the use of arrays and other subtractive techniques to identify potential mediators of the effects of loading in bone and as a result of this identified glutamate as a signalling molecule in bone. More re- cently, similar studies led to a focus on the role of receptor activity modifying proteins in cell signalling and the exciting discovery that RAMPs can alter the G-protein activation responses of a single receptor to a single hormone. Commercial applications of the RAMP biology research are the focus of Medella Thera- peutics, and the company has IP in potential cancer therapeutics

Professor Malcolm Reed Head of the Department of Oncology Malcolm qualified in medicine from the University of Sheffield in 1981. Postgraduate surgical training was undertaken in the United Kingdom and following a period of research at the University of Louisville he re- turned to Sheffield for Higher Surgical Training. Malcolm was appointed Senior Lecturer and Honorary Consultant in 1992 and subsequently was appointed to the Foundation Chair in Surgical Oncology at the University of Sheffield in 1999. Following the retirement of Professor Alan Johnson in 2003 he became Head of Academic General Surgery and is currently Head of the University Department of Oncology. Mal- colm‟s major areas of research have covered the role of microcirculation in the development and treat- ment of cancer and the regulation of genes involved in breast cancer susceptibility and development, with particular emphasis on the genes regulating angiogenesis.

Professor Anne Peat Dean of the School of Nursing & Midwifery Anne is a Nurse and Midwife by background, with expertise in leadership and management, supervision of Midwives and Quality Assurance and Enhancement. She joined the University in 1995 and is involved in teaching and assessing undergraduate, and post-graduate Nursing and Midwifery students across a wide portfolio of programmes. Anne is committed to evidence based teaching and the alignment of teaching to research and is responsible for the governance of the School ensuring standards are met and the stu- dents experience meets their needs and enables them to achieve a successful outcome and appropriate employment. Anne‟s international activities are extensive and include working with and advising Govern- ment ministers in the former USSR Republics, Poland, Brazil, Guernsey and Gibraltar.

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Professor Moira Whyte Head of the Department of Infection & Immunity Moira is a respiratory physician who trained mainly in London (St Bartholomew‟s Hospital Medical College, Hammersmith Hospital, Royal Postgraduate Medical School and Imperial Cancer Research Fund). After MRC and then Wellcome Clinical Fellowships, Moira moved to Sheffield in 1996 as Professor of Respirato- ry Medicine and Honorary Consultant in Respiratory and General Medicine. Moira‟s research interests have focussed on molecular mechanisms of innate immune cell apoptosis in the context both of chronic inflammatory lung disease and of host defence against bacterial infection. Her other role is as the Joint Acting Director of the MRC Centre for Developmental and Biomedical Genetics, which is pioneering the use of non-mammalian disease models, in particular of zebrafish and fruit flies, to understand the patho- genesis of human disease.

Professor Paul Speight Dean of the School of Clinical Dentistry Paul is the Dean of the School of Clinical Dentistry, Professor in Oral & Maxillofacial Pathology and Honor- ary Consultant Histopathologist. Previously he has worked in Riyadh, Saudi Arabia, as Postgraduate Tutor, and was Head of Oral Pathology at the Eastman Dental Institute, University College London from 1990 to 2003. He is a diagnostic histopathologist with special expertise in lesions of the jawbones, including odon- togenic cysts, and salivary glands. His research has been in understanding the pathobiology of oral disease, particularly trying to understand mechanisms of progression of oral cancer. As Dean of School he has oversight of all teaching and is particularly concerned with maintaining a high quality education informed by excellence in research and scholarship.

Dr Sheila Francis Head of the Department of Cardiovascular Science Sheila is a Reader in Cardiovascular Science at the University of Sheffield and Head of the Department of Cardiovascular Science. She held an Independent Open Competition Fellowship from the Lloyd´s Tercen- tenary Foundation on the molecular and inflammatory basis of coronary artery disease and previously spent a sabbatical period in the Hynes Lab at MIT as a Fulbright Scholar. Her long-standing interest in the role of interleukin-1 (IL-1) and its naturally occurring antagonist, IL-1ra in modulating vascular cell function in experimental models and in human disease. Current research areas of interest relate to effects of IL-1, related molecules and their antagonists on the healing of arteries after vascular injury and atherosclerosis. Dr Francis is committed to training and mentorship for postdoctoral researchers and Fellows and leads the Postdoctoral Mentoring and Fellowship Coaching Programme for the Medical School

Professor Pamela Shaw Director of the Sheffield Institute of Translational Neuroscience (SITraN) Pam‟s research group consists of a multidisciplinary team of basic and clinical scientists investigating molecular mechanisms of neurodegeneration in disorders of the human motor system, particularly motor neurone disease (MND), spinal muscular atrophy and hereditary spastic paraparesis (HSP). Her research is focused on understanding of the function of motor neurons in health and disease and translating basic science findings into health benefits for patients with degenerative motor system disorders; to provide excellent clinical care for patients with motor system disorders; and to foster excellent training for clinical and scientific junior staff with the aim of ensuring high standards of future care.

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Dr Ilaria Bellantuono Senior Lecturer Human Metabolism Ilaria‟s research is focused on the mechanisms of ageing of bone marrow-derived stem cells and the im- pact these have on tissue regeneration. She leads the innovative resource Shared Ageing Research Mod- els (ShARM) funded by the Wellcome Trust, which combines web-based information systems with a physi- cal tissue bank of ageing mouse models. She is Director of the bone analysis laboratory, at the Mellanby Centre for Bone Research, which provides access to contemporary approaches to analysing bone to the bone research community. She is also the Chair of the Early Career Group Committee for the Faculty of Medicine, which provides strategic thinking in the design of a comprehensive programme „Think Ahead‟ to equip junior researchers with a career trajectory and skills which meet the employers´ needs.

Dr John Fenner Lecturer Cardiovascular Science John is a Medical Physicist by profession and registered with the Health Professions Council in the UK. His career began in 1984 with the Department of Clinical Physics and Bioengineering in Glasgow, eventually leading to appointment as Senior Physicist, providing scientific support to the Department of Cardiac Sur- gery in Glasgow Royal Infirmary. He joined the University of Sheffield in 1996 and has been involved with a breadth of Medical Physics research related to radiation, simulation and validation. He has been a major technical contributor to numerous EU projects and most recently has been leading the Sheffield contribu- tion to the data component of the Virtual Physiological Human (VPH) initiative in Sheffield. Dr Fenner‟s in- terests have led to publications in medical radiation physics, aspects of diagnostic imaging and the VPH.

Dr Liz Williams Lecturer Human Nutrition Unit, Oncology Liz‟s research focus is the role of diet in healthy ageing and diet in the prevention of chronic disease. She has particular interests in gastrointestinal health, immune function in older adults, and dietary assessment in older adults. Her long-standing research interest in diet and intestinal health has included investigation of proteomic and methylation biomarkers of colorectal cancer, the role of butyrate and folate on colorec- tal carcinogenesis, and the impact of probiotics on irritable bowel syndrome. She has considerable expe- rience of designing and conducting randomised-controlled dietary/micronutrient intervention trials, in- cluding a number of studies with older adults. More recently Liz has been working with a multidisciplinary team to develop a sensitively designed technology to improve assessment of nutrition, physical function, cognitive function and mental health in older adults, including measures commonly used to define a physi- cally frail phenotype. Liz‟s research is funded by the ESRC-led cross Research Council, New Dynamics of Ageing Programme, the UK Technology Strategy Board and by the former UK Food Standards Agency.

Dr Ke Ning Lecturer Neuroscience Ke graduated in Medicine from the First Military Medical University (Southern Medical University) in Chi- na in 1985, obtained a MSc in neurosurgery at the Sun Yatsen University of Medical Science, China and PhD in neuroscience at the Third Military Medical University in China in 1996. He was promoted to an As- sociate Professor in Neurosurgery at Southern Medical University in China in 1997. Since 1999, he under- took research in neuroscience in the USA, Canada and UK and joined the University of Sheffield in 2006 being closely involved in translational neuroscience research and teaching in motor neuron diseases. Cur- rently his research focus is in the use of viral vector-mediated gene therapy to treat neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy (SMA).

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Dr Graham Stafford Lecturer School of Clinical Dentistry Graham is a Non Clinical Lecturer in microbiology and member of the Oral Disease Research Group. He is a molecular microbiologist by training with a focus in the dental school on investigating the pathogenic mechanisms and host responses to periodontal pathogens with a focus on the role of sialic acid in biofilms and in host cell interaction and responses. Dr Stafford is also in several interdiscpiplinary areas of re- search including: synthetic biology- namely in the area of production of novel adhesins and development of bacteria for the production of biomacromolecules for tissue engineering, discovery of novel antimicro- bials and mechanisms of bacterial protein glycosylation.

Dr Silke Fricke Lecturer Human Communication Sciences Silke joined the Department of Human Communication Sciences at the University of Sheffield in January 2011 as a Lecturer. Her principal research interests lie in the field of speech, language and literacy devel- opment and difficulties in monolingual and multilingual children, as well as the evaluation of intervention approaches. Having qualified and practised as a speech and language therapist in Germany, she came to the UK for postgraduate studies at masters level followed by a PhD in Human Communication Sciences (University of Sheffield). She worked as a Post-Doctoral Research Fellow on the Nuffield Language4Read- ing project at the Department of Psychology, University of York from 2009-2011.

Dr Colby Eaton Senior Lecturer Human Metabolism Cobly is a Senior Lecturer in the Academic Unit of Bone Biology at the University of Sheffield and Post- graduate Lead for the Department of Human Metabolism. His research interests are focused on prostate biology and prostate cancer with current studies focusing on the mechanisms by which prostate cancer cells survive and grow in skeletal metastases. He is particular interested in the mechanisms utilized by tu- mour cells to increase their genetic heterogeneity and to selectively adapt to different environments. Dr Eaton teaches oncology related topics and general scientific method on the MSc in Molecular Medicine and contributes to the Faculty and School provision for postgraduate studies.

Professor Christine Ingleton School of Nursing and Midwifery Christine is the Professor of Palliative Care Nursing in the School of Nursing and Midwifery, University of Sheffield. She also holds an Honorary Chair in the Department of Nursing at the University of Auckland, New Zealand. Her research interests are palliative and end-of-life care, views of informal carers, end-of- life care and older people, service evaluation and needs assessment, palliative care in general care set- tings, qualitative case studies and mixed methods. Professor Ingleton has served on 10 international re- search scientific committees, is a Fellow of the European Academy of Nursing Science and Fellow of the Royal Society of Arts.

Roberta Ara Industry Manager School of Health and Related Research Roberta Ara is the Senior Research Analyst in Health Economics and Decision Science at the School of Health and Related Research (ScHARR), University of Sheffield. Research interests include assessing cost- effectiveness of new treatments for NICE; cost-effectiveness modeling methods; arthritis, obesity, cardio- vascular disease. Also health related quality of life issues involving populating models with utilities and mapping between preference-based instruments. Current projects include Scientific Advice Programme for the National Institute for Health and Clinical Excellence and Policy Research Unit in Economic Evalua- tion of Health and Care Prevention (EEPRU) funded by the Department of Health.

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Dr John Stevens Industry Manager School of Health and Related Research John is Director of the Centre for Bayesian Statistics in Health Economics (CHEBS) at the University of Sheffield. After graduating from Brunel University he worked in the pharmaceutical industry for 24 years, including at SK&F Research Ltd, Wellcome Research Laboratories, GlaxoWellcome and AstraZeneca R&D Charnwood. He gained experience in the design and analysis of pre-clinical studies and in all phases of clinical drug development and held a variety of management positions. He later had a technical role in the development and application of statistical methods to improve the drug development process, with a par- ticular interest in Bayesian methods. During this time, he became interested in the application of Bayesian methods in health economics and was actively involved in the creation of CHEBS.

Dr Martina Daly Senior Lecturer Cardiovascular Science Martina joined the University of Sheffield in 1991 as a postdoctoral research Associate working on the in- vestigation of genotype-phenotype relationships in von Willebrand disease. She developed an interest in haemostasis, in particular antithrombin deficiency while completing her PhD in the Children´s Research Centre in Dublin. She was appointed Lecturer in 1992 and Senior Lecturer in 2001. Her research is aimed at improving understanding of the pathogenesis of inherited haemostatic disorders. Current work is fo- cused on the contribution of platelet receptor gene variation to the contribution of the bleeding tendency in patients with type 1 von Willebrand factor, and on the identification and characterisation of molecular defects underlying platelet bleeding disorders and inherited thrombocytopenia. Dr Daly is also the Post- graduate Research Lead for the Department of Cardiovascular Science and the University of Sheffield Medical School, and Chair of the Medical School Graduate Research Committee which develops, adminis- ters and monitors the assessment of graduate research student progress.

Professor Jon Sayers Lecturer Infection & Immunity Jon is Professor of Functional Genomics and teaches graduate classes in biochemistry, structural biolo- gy, sequence analysis, protein engineering for biotechnology and drug design. He studied Chemistry and gained a Ph.D. on nucleic acid analogues at the University of Birmingham. He spent five years with the Max -Planck-Institut for Experimental Medicine where he developed a widely used system for site-directed mutagenesis and became interested in flap endonucleases and structural biology. He currently works on proteins secreted by pathogens, using a wide range of molecular and cell biological and biophysical tech- niques to unravel the detail of such interactions aided by close collaboration with structural biologists in Sheffield and the United States. He has extensive experience of expression of toxic protein in bacteria and developing quantitative assays. He is currently the Hon. Treasurer of the Biochemical Society. In 2001 he became a director and co-founder of Asterion Ltd, a biotech spin-off company.

Professor Gerry Wilson Infection & Immunity Gerry graduated in medicine from Queens University Belfast and was awarded an ARC Clinical Fellowship for a PhD thesis entitled 'Role of TNF polymorphism in rheumatoid arthritis' which he undertook at the University of Sheffield. He was subsequently awarded an ARC Copeman Fellowship for research at Stan- ford University. Currently he is Professor in Rheumatology and Honorary Consultant Rheumatologist at the University of Sheffield. His research interests include the genetic and epigenetic background of rheu- matoid arthritis. Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease characterised by joint inflammation which frequently leads to joint damage, significant morbidity and increased mortality. The aetiology is multifactorial with a substantial genetic contribution. He is also interested in pharmaco- genetics, specifically the identification of biomarkers predictive of response to Methotrexate and anti-TNF and the role of epigenetics in immunoageing.

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Professor Paul Hatton School of Clinical Dentistry Paul is Professor of Biomaterials Science and Honorary Non-Clinical Investigator at the School of Clinical Dentistry. He is also Head of the Biomaterials Research Group and Chair of the EXPERTISSUES FP6 Net- work of Excellence Education & Training Committee. His has interests in biomaterials, medical devices and tissue engineering for clinical applications in human skeletal tissues. The five major themes for his re- search are (1) the development of bioactive glasses and ceramics for mineralised tissue repair, (2) glass- ionomer bone cements, (3) In vitro evaluation of biocompatibility, and (4) Cartilage and bone tissue engi- neering on biomaterial scaffolds. He is also active more broadly in the promotion of academic-industrial collaboration and technology transfer in the orthopaedic, craniofacial and dental material sectors.

Dr Stuart Cunningham Lecturer Human Communication Science Stuart joined the Department of Human Communication Sciences at the University of Sheffield as a Lec- turer from Barnsley Hospital where he worked as a Research Associate. He previously worked at the De- partment of Computer Science at the University of Sheffield studying the perception of filtered speech. He obtained a BEng in Software Engineering and PhD in Computer Science from the University of Shef- field. His research interests include robust automatic speech recognition; the use of speech technology in assistive technology and speech and language therapy; and the recognition and perception of speech in adverse acoustic conditions. Dr Cunningham is currently working on several projects that are developing speech-enabled assistive technology devices.

Dr Allan Lawrie Research Fellow and Head of Pulmonary Vascular Research Group Cardiovascular Science Allan completed his PhD in the Department of Cardiovascular Science at the University of Sheffield at the end of 2001. He then started his post-doctoral studies under the mentorship of Professor Marlene Rab- inovitch at Stanford University, California where he developed an interest in Pulmonary Hypertension. Al- lan spent just under 3 years at Stanford and gained his first Independent Fellowship before returning to Sheffield at the end of 2004 on a Medical School sponsored Russell Fellowship to build upon his interests in pulmonary hypertension. Allan obtained a MCR Career Development Award Fellowship in 2008 and is now currently head of the Pulmonary Vascular Research Group in the Department of Cardiovascular Sci- ence. Allan‟s main research interest lies in the molecular mechanism of pulmonary arterial hypertension (PAH), in particular, the role of osteoprotegerin (OPG), Tumor necrosis factor (TNF)-RelatedApoptosis- Inducing Ligand (TRAIL) and other related members of the TNF and IL-1 superfamilies in the pathogenesis of PAH.

Dr Peter Cudd Senior Research Associate School of Health and Related Research Peter is based in ScHARR which he joined in 2008 having previously worked in South Yorkshire Hospital Trusts. Since the mid-80´s he worked in health related research and development and in multi- disciplinary teams. The latter started with an engineering focus but increasingly driving the research by user input has resulted in leading work with more health and social science research approaches, to date primarily qualitative and mixed methods. Most of his work is focused around innovation in electronic As- sistive Technology (AT). His research interests include health electronic technology innovation, electronic AT design and evaluation. Across these areas he also has a particular interest in, `Use of IT without under- standing it´, user centred design methodologies in the health and social care context, patient and public involvement and lay research participants views on research ethics. `Use of IT without understanding it´ is practically embodied in an on-going open source project. The latter involves a Windows™ application called Maavis (Managed access to audio, visual and information services).

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Professor Fiona Boissonade School of Clinical Dentistry My major research interest is in the mechanisms of altered neuronal excitability that occur under the pathological conditions of nerve injury and inflammation, and which contribute to the development of chronic pain. Much of this research has been done at the academic–industrial interface, funded by both industry and RCUK Industrial Partnership Awards. Collaborations with GlaxoSmithKline, Pfizer and Eli Lilly include a wide range of translational studies, using pre-clinical models and human tissues to identify and validate a range of regulators of neuronal excitability as potential targets for the development of novel an- algesics. Other projects, with Renovo plc, are directed towards improvement of nerve regeneration. As a scientist and clinician I have significant experience of research training pathways for both clinical and non- clinical scientists and have supervised research council and charitable trust (including MRC, BBSRC and Wellcome Trust) funded postgraduate and postdoctoral trainees for many years.

Dr Allie Gartland Senior Lecturer Human Metabolism Allie studied biomedical technology at Sheffield Hallam University and following a period in Industry stud- ied for her PhD at The University of Liverpool on the "Expression and functional significance of the P2X7 receptor in skeletal tissue." Allie‟s principal research interest is in understanding the basic cellular and molecular mechanisms responsible for musculoskeletal disease, with an emphasis on the role of extracel- lular ATP and P2 receptors. Current projects include investigating the role of P2 receptors in bone and cartilage using both in vivo and in vitro models; the mechanisms of ATP release from osteoblasts; associa- tion of polymorphisms in the P2X7 receptor with osteoporosis and arthritis-induced joint destruction and bone loss; the effect of metal ions on bone cells in vitro and determining the bone phenotype of various knock-out mice. Allie is a founder member of the European Nucleotides and Bone Consortium, which fa- cilitates collaboration between leading European research groups working on ATP, P2 receptors and bone. Allie has secured funding from Arthritis UK, the EU Seventh Framework Programme, The Cavendish Hip Foundation and the biotechnology and pharmaceutical industry. She is currently a committee mem- ber of the Bone Research Society and founder, secretary of the UK Purine Club and the postgraduate dep- uty lead for the Department of Human Metabolism.

Dr Andy Grierson Senior Lecturer Neuroscience Andy is based at the Sheffield Institute of Translational Neuroscience at the University of Sheffield. His PhD was in molecular genetics and his research concerns identifying the molecular mechanisms underly- ing the regulation of axonal transport in health and disease. In particular investigating the involvement of axonal transport in diseases including motor neurone disease (MND) and hereditary spastic paraplegia (HSP). In addition developing and characterising novel vertebrate models of neurodegeneration in zebrafish and mouse. With support from the NC3Rs he is refining the widely used SOD1G93A model of mo- tor neuron disease.

Dr Mike Barker Lecturer Infection & Immunity Mike began his research career working as a Research Assistant for Eric Blair at the University of Leeds before studying for a PhD in leukocyte chemotaxis with Dennis Burton at the University of Sheffield. He was then awarded two independent 5-year fellowships; firstly by the Arthritis Research Campaign and then by the British Heart Foundation. During the latter fellowship he moved from the Molecular Biology & Biotechnology Department to a lectureship in the Medical School in 1997. Mike‟s current research aims towards development of novel treatments for a variety of diseases including macular degeneration and cancer.

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Kay Guccione Post-doctoral Reseaercher Training & Development Advisor Faculty of Medicine, Dentistry & Health Kay is the Faculty‟s training and professional development advisor for research staff. She joined the Facul- ty of Medicine, Dentistry and Health at the University of Sheffield in June 2010 after a four year post- doctoral research project in plant molecular biology. In her role she has overall responsibility for the man- agement, and ongoing development of the Faculty's researcher professional development programme - Think Ahead. Kay has worked in the last year to establish branding and a marketing strategy for the pro- gramme which has been nationally recognised. Kay contributes to the Faculty's strategy for post-doctoral career development and liaises with the departments across the University, other HE institutions and Vi- tae to ensure programmes are compliant with national policy. She has provided consultancy to internal and external parties in the design and development of research staff associations and researcher training programmes. Kay‟s own research is ongoing and concerns the career development paths of research staff, the design evaluation of training programmes, and the design and evaluation of mentoring programmes. Kay has formed research collaborations with Sheffield Hallam University and the UK Research Staff Asso- ciation.

James Lapworth Business Manager Sheffield Healthcare Gateway Sheffield Healthcare Gateway the department responsible for managing knowledge transfer activities from The University's Faculty of Medicine, Dentistry and Health. He is responsible for promoting, support- ing and managing industry-facing activities, including contract and collaborative research, as well as identi- fying and developing early-stage commercial opportunities. Specific areas of interest include Assistive Technologies and Digital Healthcare, Biomaterials, Oral disease, Oral Neuroscience and Tissue Engineer- ing. James has a PhD in polymer chemistry and tissue engineering from the University of Sheffield which builds on an interdisciplinary technical background encompassing synthetic chemistry, polymers, coat- ings, biomaterials, biotechnology and tissue engineering.

Karen Booth Business Manager Sheffield Healthcare Gateway Sheffield Healthcare Gateway is the University of Sheffield‟s portal to facilitate collaborations between ac- ademics and the healthcare sector. The Gateway Business Managers provide a responsive service, tai- lored to meet companies‟ innovation needs on a case-by-case basis. They match industry needs with the academic expertise, services and facilities which best suit requirements, combining academic credibility and quality with an understanding of the business environment. She is responsible for managing projects in the healthcare-technology and medical device fields, as well as coordinating clinical research between the university and Sheffield Teaching Hospitals. Karen joined the University in July 2010 and previously spent 15 years working in the pharmaceutical industry, operationally coordinating clinical trials and man- aging business development for an international contract research organisation.

Liz Maddaford Industry Manager South Yorkshire CLRN Liz Maddaford is the Industry Manager for the South Yorkshire Comprehensive Local Research Network (CLRN), of which there are 25 across England with an aim to increase high quality applied health research. Liz is responsible for all the commercial activity on the portfolio across the region - from the promotion and marketing of sites to be selected for studies through to the active performance management of re- cruitment to live studies.

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Dr Sue Smith Business Research Fellow and MRC Research Translator Centre for Developmental and Biomedical Genetics Sue Smith is a Business Research Fellow and MRC Research translator based within the MRC Centre for Developmental and Biomedical Genetics, in the Department of Biomedical Science. Her role is to facilitate the progression of research by identifying potential partners and appropriate funding opportunities. Sue graduated with a first class degree in Biochemistry from the University of Oxford in 1989, and then went on to study for a Ph. D. at European Molecular Biology Laboratory in Heidelberg, Germany. After post- doctoral training at the ZMBH, University of Heidelberg, she joined GPC Biotech Inc. (then Mitotix Inc.) in Cambridge, MA, USA in 1996, and worked in a number of scientific and development roles. On relocating to Germany, Sue was recruited to another biotech company, iOnGen AG, in 2002 working in Business De- velopment and then QA/QC. Following a move to Sheffield in 2006, she had the opportunity to work for Fusion IP plc, the University of Sheffield's commercialisation partner, prior to taking up her current posi- tion in the Department of Biomedical Science in 2007

Alison Holt Independent Research and Knowledge Exchange Fellow In her research, Alison is driven by the desire to understand how natural systems and their biodiversi- ty can be managed effectively in the face of uncertainty, given the influences and needs of human society. To achieve this, she uses empirical and experimental methods to understand large-scale patterns in biodi- versity, and employs network approaches to reveal how people make decisions about and value ecosys- tems. As Knowledge Exchange Fellow for NERC science her role is to allow environmental science to be accessed and used, and to identify areas where collaboration between researchers, the private, public and NGO sectors can be enabled. She liaises directly with external organisations, providing information on re- search and contacts. She also arranges events on specific themes to gauge interest and stimulate discus- sion between sectors.

Dr Lynsey Grieveson Senior Research Development Administrator Clinical Research Office (CRO) The CRO is a joint facility between the University of Sheffield and Sheffield Teaching Hospitals NHS Foun- dation Trust. Lynsey first came to the University of Sheffield in a similar role in 2009 following a career in the technology protection and exploitation in academia and the NHS. Prior to that, her background is in biosensors and biomedical science. Her role now concentrates primarily on two aspects; the development and coordination of clinical academic training at Sheffield in association with the Yorkshire and the Hum- ber postgraduate Deanery and the support and stimulation of translational research grant applications between the two institutions of the CRO in accordance with the joint research strategy.

Dr Tanya Loughran Industry Lead Clinical Research Office Tanya Loughran is the Clinical Research Office Sheffield Industry Lead and a member of the CRO Sheffield Industry Team. The Industry Team aims to promote an enhanced research profile (number of studies and study income) for Industry sponsored studies, via a joint UoS/STH Clinical Research Office and in partner- ship with the SYCLRN by: Providing an outstanding service to Industry and Investigators Developing the reputation of Sheffield (CRO/SYCLRN) as a world-class environment for undertaking industry sponsored research. Establishing Sheffield (CRO/SYCLRN) as a preferred site for multi-centre clinical research in part- nership with industry.

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Dr Sandrine Soubes Researcher Development Manager Faculty of Science Sandrine Soubes is the Researcher Development Manager in the Faculty of Science. She delivers and co- ordinates a varied professional development programme to PhD students and postdoctoral researchers. She has lead the introduction of innovative CPD opportunities for Sheffield researchers, such as the Shef- field Crucible, Springboard for women and Postdoc-led working groups (e.g. Career Coaching Partnership or Fellowship Coaching Partnerships). Sandrine holds a PhD in Molecular Parasitology. She has worked as a researcher in the USA and in the UK on diverse topics such the cell cycle, malaria, and early brain devel- opment. Her current scholarly work is the area of researchers' professional development. Sandrine has also a strong interest and experience in public engagement and outreach.

Professor Lorraine Maltby Head of the Department of Animal and Plant Sciences Lorraine Maltby is Professor in Environmental Biology, and Head of the Department of Animal and Plant Sciences. Prior to taking over as Head of Department, Lorraine was Director of Teaching for Animal and Plant Sciences, and has also served on the Faculty Student Review Committee and Faculty Teaching Affairs Committee. She has previously been awarded the Exceptional Service Award (2005) and the Environmen- tal Educational Award (2009) by the Society of Environmental Toxicology and Chemistry. Amongst many other professional duties, Lorraine is a member of the European Centre for Ecotoxicology and Toxicology of Chemicals Scientific Committee, the European Food Standards Agency Expert Working Group, and also the Catchment Science Centre Management Board.

Professor David Hornby Head of the Department of Molecular Biology and Biotechnology David Hornby is a Professor in Protein Biochemistry, and Head of the Department of Molecular Biology and Biotechnology. He is a member of the Biochemistry and Genomics Group, with the research interests of his laboratory include structure function relationships in proteins which participate in a range of biological processes including DNA modifications, in channelling, and gamete recognition.

Professor David Mowbray Head of the Department of Physics and Astronomy David Mowbray is Head of the Department of Physics and Astronomy. David is a member of the Inorganic Semiconductors Group within the department of Physics and Astronomy, with research interests involv- ing optical spectroscopy of semiconductor nanostructures and devices. David is coordinator of the Optics Section of the EU network of excellence SANDiE (Self-Assembled semiconductor Nanostructures for new Devices in photonics and Electronics.).

Professor Liz Smythe Biomedical Science Liz Smythe is a Professor of Molecular Cell Biology within the Department of Biomedical Science. Liz gained her B.A and PhD from Trinity College, Dublin, before undertaking postdoctoral research at the Uni- versity of Dundee (1986-1989). She was then awarded a NATO/SERC postdoctoral fellowship at The Scripps Research Institute in California (1989-1992), before becoming a MRC Senior Fellow and Principle Investigator at the Wellcome Trust Biocentre, University of Dundee (1992-2002). Liz then moved to The University of Sheffield in 2002 to become Professor of Molecular Cell Biology. The research interests of her laboratory include the molecular mechanisms of cargo sorting along the endocytic pathway, and the interplay between endocytic trafficking and signalling pathways. Liz is a member of the Faculty of 1000, the Editorial Board of the Biochemical Journal, and also Executive Secretary of the British Society for Cell Biol- ogy.

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Professor David Lidzey Physics and Astronomy David Lidzey is a Professor within the Department of Physics and Astronomy. David obtained both his BSc at the University of Birmingham, and after working for 2 years at Kodak Ltd, he returned to Birmingham University to study for a PhD (awarded in 1994). His research was based around the use of the biolumines- cent enzyme luciferase as a molecular-electronic switch for application in a massively-parallel pattern- recognition system. In 1995 he moved to the Department of Physics and Astronomy at the University of Sheffield to undertake postdoctoral research. He was later awarded the Lloyds of London Tercentenary Research Fellowship in 1997 and an EPSRC Advanced Research Fellowship in 1999 to study the optical and electronic properties of organic nanostructures. He was promoted to a personal chair in 2007, and heads the Sheffield Electronic and Photonic Molecular Materials group (EPMM) in the Department of Physics and Astronomy. He has a strong interest in the study of photonic and optoelectronic devices containing organic materials.

Dr Patrick Fairclough Reader Chemistry Patrick Fairclough is a Reader in Polymer Chemistry, and also a member of the Polymer Centre at the Uni- versity of Sheffield. Patrick obtained his PhD at the University of Birmingham in 1994 before undertaking postdoctoral research at UMIST (1994-97). In 1997 he became a Lecturer at the University of Sheffield, where he is currently a Reader. Patrick founded the Polymer Scattering group in 1998 along with Prof. To- ny Ryan, a multidisciplinary research group with strong ties to industry.

Professor Neil Spooner Physics and Astronomy Neil Spooner is a Professor within the Department of Physics and Astronomy. Neil is head of the Particle Physics and Particle Astrophysics group, which has a strong history of Knowledge Exchange (KE) activity, and strong links with local and national industry, government bodies, MOD, Home Office, Research Coun- cils and the EU FP6/7 programmes. Neil‟s research interests include dark matter searches, and neutrino physics and astrophysics. He heads the Boulby Underground Laboratory, and is a Director of the Institute for Underground Science. Neil is also coordinator of the Underground laboratories Network within EU FP6 programme ILIAS, member of the Governing council of the ILIAS programme, and hair of the Interna- tional Advisory Committee for the Workshop series „Identification of Dark Matter.‟

Dr Liam Sutton Science Gateway Liam Sutton studied Chemistry at Oxford and Nottingham and worked as a research chemist in academia and industry until 2006. He then moved into a business development role at Sheffield's Polymer Centre and became Polymer Centre Manager in 2008.The Polymer Centre is a network of 45 academic research groups at the University of Sheffield. Located in our Faculties of Science, Engineering and Medicine, its in- terests span all areas of polymer science and technology and it is the UK's largest single-university aca- demic network in the field. A central team, managed by Liam, markets the expertise and facilities of the Polymer Centre to external partners, offering both training and technology opportunities. On the training side, the Centre runs the IOM3-accredited Polymer Science and Technology modular course and offers bespoke programmes for on-site tuition at the larger companies. It also manages several polymer-related conferences and other events each year.The Centre's technology services are based on speaking to part- ners about their business or technical needs, mapping those needs onto the specific interests of academic members and determining the best format for interaction. It assists in applying for third-party funding and setting up supply-chain collaborations and it helps with project management where appropriate. The Cen- tre regularly uses Sheffield's contract research spin-out, FaraPack Polymers Ltd (of which Liam is Manag- ing Director), to serve needs for short- to medium-term laboratory-based work on a fully commercial ba- sis.