1 LETTER Castration-Mediated IL-8 Promotes Myeloid Infiltration And
bioRxiv preprint doi: https://doi.org/10.1101/651083; this version posted May 28, 2019. The copyright holder for this preprint (which was not certified by peer review) is the author/funder. All rights reserved. No reuse allowed without permission. 1 LETTER 2 Castration-mediated IL-8 Promotes Myeloid Infiltration and Prostate Cancer 3 Progression 4 Keywords: androgen receptor, CXCL8, CXCR2, immunotherapy, PMN-MDSCs, 5 myeloid-derived suppresor cells. 1,2,3 1 3 6 Zoila A. Lopez-Bujanda , Michael C. Haffner , Matthew G. Chaimowitz , Nivedita 1,2,3 3 3 4 7 Chowdhury , Nicholas J. Venturini , Aleksandar Obradovic , Corey S. Hansen , 4 5 8 Joanna Jacków , Karen S. Sfanos1,5, Charles J. Bieberich6,7, Paula J. Hurley , Mark J. 8 8,9 4,10 9 Selby , Alan J. Korman , Angela M. Christiano , Angelo M. De Marzo1,5, and Charles 3,11,12 10 G. Drake . 11 1Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, 2 12 USA; Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University, 13 Baltimore, MD, USA; 3Columbia Center for Translational Immunology, Columbia 14 University Medical Center, New York, NY, USA; 4Department of Dermatology, Columbia 15 University, New York, NY, USA; 5Departments of Urology and Oncology, Johns Hopkins 16 University School of Medicine, Baltimore, MD, USA; 6Department of Biological Sciences, 17 University of Maryland Baltimore County, Baltimore, Maryland; 7University of Maryland 18 Marlene and Stewart Greenebaum Cancer Center, Baltimore, Maryland; 8Bristol-Myers 19 Squibb, Redwood City, CA, USA; 9Current affiliation: Vir Biotechnology, San Francisco, 10 20 CA; Department of Genetics & Development, Columbia University, New York, NY, USA; 1 bioRxiv preprint doi: https://doi.org/10.1101/651083; this version posted May 28, 2019.
[Show full text]