Lungkine (CXCL15), Murine Recombinant

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BioVision 05/18 For research use only Lungkine (CXCL15), Murine Recombinant CATALOG NO: P1296-5, 20 5 µg, 20 µg RELATED PRODUCTS: ALTERNATE NAMES: CXCL15, Lungkine, Small-inducible cytokine B15, Scyb15, Weche, CXCL4, Human Recombinant (Cat. No. 7346) C-X-C motif chemokine 15 CXCL2, Human Recombinant (Cat. No. 7306) SOURCE: E.coli CXCL10/IP-10/CRG-2, human recombinant (Cat. No. 4277) CXCL14/BRAK, human recombinant (Cat. No.4278) PURITY: ≥ 98% by SDS-PAGE analyses CXCL16, Human Recombinant (Cat. No. 7130) MOL. WEIGHT: 16.3 kDa CXCL17, Human Recombinant (Cat. No. 7345) FORM: Lyophilized GCP-2 (CXCL6), human recombinant (Cat. No. 7153) IP-10, human recombinant (Cat. No. 4200) STORAGE CONDITIONS: Store at -20°C. After reconstitution, aliquot and store at -20°C to - MIG/CXCL9, murine recombinant (Cat. No. 7172) 80°C. Avoid repeated freezing and thawing cycles. PF-4/CXCL4, murine recombinant (Cat. No. 7187) BIOLOGICAL ACTIVITY: Determined by its ability to chemoattract human neutrophils using SDF-1beta (CXCL12), murine recombinant (Cat. No. 4391) a concentration range of 20.0-100.0 ng/ml SDF-1β/CXCL2, rat recombinant (Cat. No. 7200) RECONSTITUTION: Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended reconstitute with sterilized distilled water or 0.1% BSA aqueous buffer and store in working aliquots at -20°C to - 80°C. DESCRIPTION: Lungkine is a CXC chemokine that is expressed in lung epithelial cells and, to a lesser extent, in certain fetal tissues. No human homolog has been identified and a specific cell surface receptor has not yet been found. Lungkine expression in lung tissue is elevated in response to inflammation, at which time it acts to specifically recruit neutrophils and direct them into the lung airway. Recombinant murine Lungkine is a 16.3 kDa CXC chemokine consisting of 142 amino acid residues, including four conserved cysteine residues present in CXC chemokines. FOR RESEARCH USE ONLY! Not to be used on humans. BioVision Incorporated Tel: 408-493-1800 | Fax: 408-493-1801 155 S. Milpitas Boulevard, Milpitas, CA 95035 USA www.biovision.com | [email protected] .

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The Effect of Hypoxia on the Expression of CXC Chemokines and CXC Chemokine Receptors—A Review of Literature
International Journal of Molecular Sciences Review The Effect of Hypoxia on the Expression of CXC Chemokines and CXC Chemokine Receptors—A Review of Literature Jan Korbecki 1 , Klaudyna Kojder 2, Patrycja Kapczuk 1, Patrycja Kupnicka 1 , Barbara Gawro ńska-Szklarz 3 , Izabela Gutowska 4 , Dariusz Chlubek 1 and Irena Baranowska-Bosiacka 1,* 1 Department of Biochemistry and Medical Chemistry, Pomeranian Medical University in Szczecin, Powstańców Wielkopolskich 72 Av., 70-111 Szczecin, Poland; [email protected] (J.K.); [email protected] (P.K.); [email protected] (P.K.); [email protected] (D.C.) 2 Department of Anaesthesiology and Intensive Care, Pomeranian Medical University in Szczecin, Unii Lubelskiej 1, 71-281 Szczecin, Poland; [email protected] 3 Department of Pharmacokinetics and Therapeutic Drug Monitoring, Pomeranian Medical University in Szczecin, Powstańców Wielkopolskich 72 Av., 70-111 Szczecin, Poland; [email protected] 4 Department of Medical Chemistry, Pomeranian Medical University in Szczecin, Powstańców Wlkp. 72 Av., 70-111 Szczecin, Poland; [email protected] * Correspondence: [email protected]; Tel.: +48-914661515 Abstract: Hypoxia is an integral component of the tumor microenvironment. Either as chronic or cycling hypoxia, it exerts a similar effect on cancer processes by activating hypoxia-inducible factor-1 (HIF-1) and nuclear factor (NF-κB), with cycling hypoxia showing a stronger proinflammatory influ- ence. One of the systems affected by hypoxia is the CXC chemokine system. This paper reviews all available information on hypoxia-induced changes in the expression of all CXC chemokines (CXCL1, CXCL2, CXCL3, CXCL4, CXCL5, CXCL6, CXCL7, CXCL8 (IL-8), CXCL9, CXCL10, CXCL11, CXCL12 Citation: Korbecki, J.; Kojder, K.; Kapczuk, P.; Kupnicka, P.; (SDF-1), CXCL13, CXCL14, CXCL15, CXCL16, CXCL17) as well as CXC chemokine receptors— Gawrońska-Szklarz,B.; Gutowska, I.; CXCR1, CXCR2, CXCR3, CXCR4, CXCR5, CXCR6, CXCR7 and CXCR8.
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Mouse CXCL15 ELISA Kit (ARG82062)
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Supplemental Figures 1-3 and Supplemental Table 1 (PDF, 155
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